Proteasas / Proteasoma
Los inhibidores de proteasas y proteasomas son compuestos que bloquean la actividad de las proteasas y del proteasoma, que están involucrados en la degradación y renovación de proteínas. Estos inhibidores son vitales para estudiar la regulación de la homeostasis proteica, el control del ciclo celular y la apoptosis. Los inhibidores de proteasas y proteasomas también se utilizan en el tratamiento de enfermedades como el cáncer, donde la degradación anormal de proteínas desempeña un papel en la progresión de la enfermedad. Al inhibir las proteasas o el proteasoma, estos compuestos pueden inducir la muerte celular en células cancerosas y son herramientas esenciales tanto en la investigación básica como en el desarrollo terapéutico. En CymitQuimica, ofrecemos una amplia gama de inhibidores de proteasas y proteasomas de alta calidad para apoyar su investigación en bioquímica, biología celular y desarrollo de fármacos.
Subcategorías de "Proteasas / Proteasoma"
- Acetil-CoA Carboxilasa(35 productos)
- Cisteína proteasa(106 productos)
- DPP-4(20 productos)
- Glutaminasa(41 productos)
- Proteasa del VIH(474 productos)
- PAI-1(26 productos)
- Inhibidores de la proteasa(50 productos)
- Receptor activado por proteasa(53 productos)
- Proteasoma(95 productos)
- Serina proteasa(54 productos)
- p97(16 productos)
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Se han encontrado 1076 productos de "Proteasas / Proteasoma"
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Cathepsin K inhibitor 2
CAS:Cathepsin K inhibitor 2 targets CTSK gene, may treat osteoporosis and osteoarthritis, detailed in patent WO2021147882A1.Fórmula:C30H33F4N5O3Forma y color:SolidPeso molecular:587.61(2S,4R)-Teneligliptin
CAS:(2S,4R)-Teneligliptin is a selective inhibitor of dipeptidyl peptidase IV (DPP-4). It increases the concentration of active glucagon-like peptide-1 (GLP-1) in plasma, which in turn stimulates insulin secretion when blood glucose levels are elevated, thereby exhibiting hypoglycemic effects. (2S,4R)-Teneligliptin is a promising candidate for research in type 2 diabetes.Fórmula:C22H30N6OSForma y color:SolidPeso molecular:426.578RJF02215
CAS:RJF02215, an MMP-9 inhibitor, exhibits growth inhibitory activity against the ovarian cancer cell line SKOV3. It is utilized in tumor research.Fórmula:C17H12ClN3OS3Forma y color:SolidPeso molecular:405.95TMPRSS6-IN-1 TFA
<p>TMPRSS6-IN-1 (TFA) is a potent inhibitor of TMPRSS6 (Matriptase-2), a member of the TTSP family (a type of transmembrane serine protease). TMPRSS6 is a type II TTSP, and genetically reduced levels of TMPRSS6 have been shown to improve symptoms of hemochromatosis and β-thalassemia in mice.</p>Fórmula:C35H41F3N8O6S2Forma y color:SolidPeso molecular:790.875BI-1915
CAS:<p>BI-1915 is a selective inhibitor of Cathepsin S, with an IC50 of 17 nM. It is utilized in the research of autoimmune diseases.</p>Fórmula:C21H37N5O3Forma y color:SolidPeso molecular:407.55Plasma kallikrein-IN-2
Plasma kallikrein-IN-2: PKal inhibitor, IC50=0.1 nM. Used in angioedema, diabetic eye disease research.Fórmula:C28H24ClF3N8O3Forma y color:SolidPeso molecular:612.99Valopicitabine
CAS:<p>Valopicitabine is an effective prodrug of the effective anti-HCV drug 2'-C-methylcytidine and can be used as a promising antiviral drug for the study of chronic</p>Fórmula:C15H24N4O6Pureza:98%Forma y color:SolidPeso molecular:356.37(2R,3S)-Emricasan
CAS:<p>(2R,3S)-Emricasan ((2R,3S)-PF 03491390) is an isomer of Emricasan. This compound acts as an orally effective irreversible pan-caspase inhibitor. (2R,3S)-Emricasan inhibits the increase in caspase-3 activity induced by Zika virus (ZIKV) and protects human cortical neural progenitor cells.</p>Fórmula:C26H27F4N3O7Forma y color:SolidPeso molecular:569.5Cathepsin C-IN-3
Cathepsin C-IN-3 is a potent inhibitor of histone C (IC50: 61.79 nM) and also inhibits THP-1 cells (IC50: 101.5 nM) and U937 cells (IC50: 86.5 nM).Fórmula:C28H21F3N6OSForma y color:SolidPeso molecular:546.57HCV-IN-38
Potent oral HCV inhibitor HCV-IN-38 has 15 nM EC50, 431 SI, high efficacy, and low toxicity.Fórmula:C22H24ClF3N4O4Forma y color:SolidPeso molecular:500.9HCV NS5B polymerase-IN-2
CAS:HCVNS5B polymerase-IN-2 (Compound 298) is an inhibitor of the Ns5b polymerase. It holds potential for research into the treatment of hepatitis C virus (HCV) infections.Fórmula:C26H24N2O4Forma y color:SolidPeso molecular:428.48HCV-IN-40
CAS:<p>HCV-IN-39 is a potent oral drug inhibiting HCV, effective on GT1a (EC50: 0.259μM), GT1b (EC50: 0.434μM), GT1b CES1 (EC50: 0.069μM) replicons.</p>Fórmula:C21H26BrFN3O9PForma y color:SolidPeso molecular:594.32GSK5852
GSK5852, an HCV NS5B inhibitor, has IC50 of 50 nM; potently fights HCV with EC50 of 3.0 nM for GT1a and 1.7 nM for GT1b.Fórmula:C27H27BF2N2O6SForma y color:SolidPeso molecular:556.39UK-370106
CAS:<p>UK-370106 is a potent and highly selective inhibitor of MMP-3 with IC50 of 23 nM and MMP-12 with IC50 of 42 nM, and potently inhibits cleavage of [3H]-</p>Fórmula:C35H44N2O5Pureza:98%Forma y color:SolidPeso molecular:572.73(1R,3S)-THCCA-Asn
<p>(1R,3S)-THCCA-Asn (4j) is a selective inhibitor of thrombin (IC50: 0.07-0.14 μM) with anti-thrombotic effects.</p>Fórmula:C24H24N4O6Forma y color:SolidPeso molecular:464.47RBx-0597
CAS:<p>RBx-0597 is a selective DPP-IV inhibitor with IC50 values of 32 nM, 31 nM, and 39 nM for human, mouse, and rat plasma DPP-IV, respectively. It is utilized in research focused on type 2 diabetes.</p>Fórmula:C19H20F2N4O2Forma y color:SolidPeso molecular:374.384Tilpisertib fosmecarbil
CAS:Tilpisertib fosmecarbil is a potent inhibitor of serine/threonine kinases with anti-inflammatory properties.Fórmula:C35H36ClN8O7PForma y color:SolidPeso molecular:747.14RO5461111
CAS:RO5461111: Oral Cathepsin S inhibitor, IC50 of 0.4 nM (human) & 0.5 nM (mouse), reduces T/B cell activation, treats lung inflammation & lupus nephritis.Fórmula:C27H24F6N4O4SForma y color:SolidPeso molecular:614.56BI 224436
CAS:<p>BI 224436 is an inhibitor of HIV-1 noncatalytic site integrase. With EC50 values of less than 15 nM against different HIV-1 laboratory strains.</p>Fórmula:C27H26N2O4Forma y color:SolidPeso molecular:442.51Freselestat quarterhydrate
ONO-6818 quarterhydrate: oral neutrophil elastase inhibitor, Ki 12.2 nM; >100x less effective on other proteases; strong anti-inflammatory.Fórmula:C23H30N6O5Forma y color:SolidPeso molecular:457.03Anti-infective agent 10
CAS:<p>Anti-infective agent 10 (Compound Example 30) is an ns5b polymerase inhibitor that functions as an anti-HCV agent.</p>Fórmula:C26H25N3O7SForma y color:SolidPeso molecular:523.56DPP-4-IN-15
CAS:DPP-4-IN-15 (Compound 22) is a non-competitive inhibitor of dipeptidyl peptidase-4 (DPP-4) with an IC50 value of 8.24 μM.Fórmula:C17H14F3N3O2SForma y color:SolidPeso molecular:381.372SBI-581
<p>SBI-581: oral, potent TAO3 inhibitor, IC50=42nM, alters TKS5α at RAB11+ vesicles, blocks invadopodia, good mouse pharmacokinetics, anti-tumor.</p>Fórmula:C24H21N3O2Forma y color:SolidPeso molecular:383.44PNU-248686A
CAS:PNU-248686A is an inhibitor of matrix metalloproteinase (MMP).Fórmula:C22H18ClNaO5S2Pureza:98%Forma y color:SolidPeso molecular:484.95Cyclophilin inhibitor 1
CAS:Cyclophilin inhibitor 1: orally available, Kd 5 nM, potent against HCV, EC50 for HCV 2a is 98 nM.Fórmula:C31H39N5O7Pureza:98%Forma y color:SolidPeso molecular:593.67ABT-072
CAS:<p>ABT-072 is a nonnucleoside NS5B polymerase inhibitor and a candidate drug evaluated for treatment of hepatitis C virus.</p>Fórmula:C24H27N3O5SPureza:98%Forma y color:SolidPeso molecular:469.55Cathepsin C-IN-5
CAS:<p>Cathepsin C-IN-5 (SF38) is a potent, oral Cathepsin C blocker with an IC50 of 59.9 nM; less active against Cat L/S/B/K; has anti-inflammatory effects.</p>Fórmula:C21H17ClN6OSForma y color:SolidPeso molecular:436.92Faldaprevir
CAS:Faldaprevir is an orally effective, selective, non-covalent HCV NS3/4A protease inhibitor with high inhibitory activity against HCV 1a and 1b genotype.Fórmula:C40H49BrN6O9SPureza:99.04% - 99.19%Forma y color:SolidPeso molecular:869.82HCV-IN-7
CAS:HCV-IN-7: potent oral HCV NS5A inhibitor, pan-genotypic, IC50s 3-47 pM, good pharmacokinetics, favorable liver uptake.Fórmula:C40H48N8O6SPureza:98%Forma y color:SolidPeso molecular:768.92Idraparinux Na
CAS:Idraparinux Na is an Antithrombotic, Indirect, Selective, Synthetic Factor Xa InhibitorFórmula:C38H55Na9O49S7Forma y color:SolidPeso molecular:1727.14GLS-1-IN-1
<p>GLS-1-IN-1 (compound 1d) is a GLS-1 inhibitor that inhibits Hep G2, MCF 7 and MCF 10A cells.</p>Fórmula:C26H25FN4OSForma y color:SolidPeso molecular:460.57Odiparcil
CAS:<p>Odiparcil is an orally active beta-d-thioxyloside analog.</p>Fórmula:C15H16O6SPureza:98%Forma y color:SolidPeso molecular:324.35BAY-7598
CAS:<p>BAY-7598 is a potent, selective, and orally bioavailable MMP12 inhibitor (IC50s: 0.085, 0.67, and 1.1 nM for human/murine/rat MMP12).</p>Fórmula:C28H31N3O6Pureza:98%Forma y color:SolidPeso molecular:505.56GW311616 hydrochloride
CAS:<p>GW-311616 hydrochloride is a long duration, orally bioavailable, and selective human neutrophil elastase (HNE) inhibitor (IC50: 22 nM; Ki: 0.31 nM).</p>Fórmula:C19H32ClN3O4SPureza:98%Forma y color:SolidPeso molecular:433.99AMG-222 tosylate
CAS:<p>AMG-222 tosylate is a DPP-IV inhibitor in clinical development for type II diabetes.</p>Fórmula:C39H47N9O6SForma y color:SolidPeso molecular:769.91M826
<p>M826, a non-peptide, potent, selective, and reversible caspase-3 inhibitor, exhibits an IC50 of 0.005 μM and demonstrates strong anti-apoptotic activity in</p>Fórmula:C28H45N7O6Pureza:98%Forma y color:SolidPeso molecular:575.7BI-1942
CAS:<p>BI-1942 is a chymase inhibitor with an IC50 value of 0.4 nM against human chymase. It is applicable for research in ophthalmic diseases.</p>Fórmula:C24H26N4O4Forma y color:SolidPeso molecular:434.488Valopicitabine dihydrochloride
CAS:Valopicitabine, a NS5B inhibitor, is used potentially for the treatment of HCV infection.Fórmula:C15H25ClN4O6Forma y color:SolidPeso molecular:392.84Antiplatelet agent 3
CAS:<p>Antiplatelet agent 3 (Compound K-10) is a compound with antiplatelet aggregation activity, exhibiting IC50 values of 2.55, 3.22, and 2.09 mg/mL for platelet aggregation induced by ADP, AA, and COL, respectively. It holds potential for research in cardiovascular diseases.</p>Fórmula:C38H32N2O5Forma y color:SolidPeso molecular:596.671Plodicitinib
CAS:Plodicitinib is an inhibitor of Janus tyrosine kinase 3/TEC family kinase, exhibiting anti-inflammatory properties.Fórmula:C19H22FN7O2Forma y color:SolidPeso molecular:399.422Dup-714
CAS:Dup-714 is a thrombin inhibitor.Fórmula:C21H33BN6O5Pureza:98%Forma y color:SolidPeso molecular:460.33Human enteropeptidase-IN-2
<p>Human enteropeptidase-IN-2 is a potent inhibitor of enteropeptidase (enteropeptidase) and can be used in anti-obesity studies.</p>Fórmula:C20H19F3N4O7Forma y color:SolidPeso molecular:484.38Zetomipzomib
CAS:KZR-616: Immunoproteasome inhibitor targeting LMP7 (IC50: 39/57 nM) & LMP2 (IC50: 131/179 nM), potential in autoimmune disease research.Fórmula:C30H42N4O8Forma y color:SolidPeso molecular:586.68Deleobuvir
CAS:Deleobuvir(BI207127) is an inhibitor of non-nucleoside hepatitis C virus NS5B polymerase for the treatment of hepatitis C.Fórmula:C34H33BrN6O3Forma y color:SolidPeso molecular:653.57GW311616
CAS:GW-311616 is a long duration, orally bioavailable, and selective human neutrophil elastase (HNE) inhibitor (IC50: 22 nM; Ki: 0.31 nM).Fórmula:C19H31N3O4SForma y color:SolidPeso molecular:397.53TCL1
CAS:TCL1 acts as a selective non-covalent inhibitor targeting the Pru domain of the Rpn-13 subunit within the 19S regulatory particle (19S RP) of the proteasome, with an IC50 value around 26 μM. It disrupts the recognition and transport of ubiquitinated proteins by Rpn-13, thus inhibiting proteasomal degradation and affecting intracellular protein metabolism balance. TCL1 holds potential for research in hematologic malignancies.Fórmula:C19H14BrClN4O2SForma y color:SolidPeso molecular:477.762Napsagatran hydrate
CAS:Napsagatran hydrate is a novel and specific inhibitor of thrombin.Fórmula:C26H36N6O7SPureza:98%Forma y color:SolidPeso molecular:576.66ZINC09518833
CAS:<p>ZINC09518833 is an α-ketoamide non-peptide proteasome inhibitor with an IC50 value of 12.4 μM. It can bind with both the active and inactive sites of the proteasome. ZINC09518833 shows promise for use in research related to multiple myeloma (MM).</p>Fórmula:C24H25N3O5Forma y color:SolidPeso molecular:435.47Tyrosinase-IN-37
CAS:<p>Tyrosinase-IN-37 (Compound 3c) is a potent inhibitor of tyrosinase, with an IC50 value of 1.02 μM, which is 14 times more effective than kojic acid (IC50 of 14.74 μM). This compound effectively prevents the browning of Rosa roxburghii and can also inhibit browning not caused by tyrosinase.</p>Fórmula:C12H12N6SForma y color:SolidPeso molecular:272.33BMT-052
CAS:<p>BMT-052 is a potent and selective Pan-genotypic HCV NS5B Polymerase Inhibitor (EC50 = 7 nM).</p>Fórmula:C30H17D9F4N6O5Pureza:98%Forma y color:SolidPeso molecular:635.61SSR-182289A (Free)
CAS:SSR-182289A (Free) is a thrombin inhibitor.Fórmula:C30H33F2N5O4SPureza:98%Forma y color:SolidPeso molecular:597.68Beclabuvir
CAS:<p>Beclabuvir blocks HCV NS5B polymerase at thumb site 1, effective on genotypes 1, 3, 4, 5 with IC50 <28 nM.</p>Fórmula:C36H45N5O5SPureza:99.87% - 99.93%Forma y color:SolidPeso molecular:659.84CM-352
CAS:CM-352 is a metalloproteinase inhibitor that reduces brain damage and improves functional recovery in rat models of cerebral hemorrhage.Fórmula:C24H29N3O6SPureza:97.24%Forma y color:SolidPeso molecular:487.57Immunoproteasome activator 1
CAS:Immunoproteasome Activator 1 (compound A) is a selective immunoproteasome activator that enhances the presentation of individual MHC-I binding peptides by over 100 times. It binds to the proteasomal structural subunit PSMA1 and facilitates the association of the proteasome activators PA28α/β (PSME1/PSME2) with the immunoproteasome.Fórmula:C24H23N3O3Forma y color:SolidPeso molecular:401.46Monosodium 2-sulfoterephthalate
CAS:<p>Monosodium 2-sulfoterephthalate (8) is an inhibitor of glutamate carboxypeptidase II.</p>Fórmula:C8H5NaO7SForma y color:SolidPeso molecular:268.176Gemigliptin tartrate hydrate
CAS:Gemigliptin (LC15-0444) tartrate hydrate is a selective, reversible, and competitive inhibitor of dipeptidyl peptidase 4 (DPP-4), with an IC50 value of 10.3 nM for human recombinant DPP-4. It exhibits strong anti-glycation properties and is used in research on advanced glycation end product-related diabetic complications.Fórmula:C22H27F8N5O9Forma y color:SolidPeso molecular:657.47RXP03
CAS:RXP03 is an MMPs inhibitor with K_i values of 20 nM for MMP-2, 2.5 nM for MMP-8, 10 nM for MMP-9, 5 nM for MMP-11, and 105 nM for MMP-14 [1].Fórmula:C39H43N4O6PForma y color:SolidPeso molecular:694.76Faldaprevir sodium
CAS:Faldaprevir sodium: HCV treatment, inhibits NS3/NS4A protease, P-glycoprotein, CYP3A4, UGT1A1.Fórmula:C40H48BrN6NaO9SForma y color:SolidPeso molecular:891.81Pyridoxatin
CAS:Pyridoxatin: fungal metabolite; blocks TBARS production, prevents AAPH-induced hemolysis, and acts against C. albicans.Fórmula:C15H21NO3Forma y color:SolidPeso molecular:263.33PLGLAG
CAS:PLGLAG is a peptide chain that acts as a linker in activatable cell-penetrating peptides (ACPPs). ACPPs containing the PLGLAG linker are primarily sensitive to MMP-2 and MMP-9 in vivo. PLGLAG is applicable in cancer research.Fórmula:C24H42N6O7Forma y color:SolidPeso molecular:526.63MMP-13-IN-1
CAS:MMP-13-IN-1, with an IC50 value of 16 nM, is a potent and selective inhibitor of MMP-13, suitable for atherosclerosis research [1].Fórmula:C19H16F3N3O3Forma y color:SolidPeso molecular:391.34MIV-247
CAS:MIV-247 is a cathepsin S inhibitor that attenuates mechanically abnormal pain in preclinical neuropathic pain models and can be used to study myocardial injury.Fórmula:C17H24F3N3O4Pureza:99.27%Forma y color:SolidPeso molecular:391.39JTK-109
CAS:JTK-109 is an inhibitor of hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitor and inhibits G1b and G3a subgenomic replicons and recombinant enzymes.Fórmula:C37H33ClFN3O4Pureza:98.48% - 99.68%Forma y color:SolidPeso molecular:638.13IDX184
CAS:<p>IDX184 is a potent, orally active, targeted HCV polymerase inhibitor and nucleoside polymerase.IDX184 effectively inhibits HCV polymerase (IC50=0.31 μM, Ki=52.3</p>Fórmula:C25H35N6O9PSPureza:97.15%Forma y color:SolidPeso molecular:626.62Vaniprevir
CAS:Vaniprevir is a competitive HCV NS3/4A protease inhibitor, an antiviral(hepatitis C virus) drug that acts directly and blocks the viral replication process.Fórmula:C38H55N5O9SPureza:97.41%Forma y color:SolidPeso molecular:757.94PD 151746
CAS:<p>PD151746: calpain inhibitor, Ki μ-calpain=0.26μM, Ki m-calpain=5.33μM; reduces oxLDL cytotoxicity.</p>Fórmula:C11H8FNO2SPureza:98.63% - ≥95%Forma y color:SolidPeso molecular:237.25Sebetralstat
CAS:<p>Sebetralstat (KVD900) is an inhibitor of plasma kallikrein and can be used in studies about metabolic diseases.</p>Fórmula:C26H26FN5O4Pureza:99.85%Forma y color:SolidPeso molecular:491.512,7,10,12-Tetraazatridecanoic acid, 4-hydroxy-12-methyl-9-(1-methylethyl)-13-[2-(1-methylethyl)-4-thiazolyl]-8,11-dioxo-3,6-bis(phenylmethyl)-, 5-thiazolylmethyl ester, (3S,4S,6S,9S)-
CAS:Fórmula:C37H48N6O5S2Pureza:≥98%Forma y color:SolidPeso molecular:720.9442MMP13-IN-2
CAS:<p>MMP13-IN-2 is a highly potent, selective, and orally active inhibitor of MMP-13. It demonstrates exceptional potency against MMP-13, with an IC50 value of 0.036 nM, and exhibits selectivities greater than 1,500-fold over MMP-1, 3, 7, 8, 9, 14, and TACE. Moreover, MMP13-IN-2 possesses the capability to effectively inhibit collagen release from cartilage in vitro. Consequently, MMP13-IN-2 holds great potential for advancing research on collagenase-related diseases.</p>Fórmula:C24H19FN6O4SForma y color:SolidPeso molecular:506.513-Deazaadenosine
CAS:3-Deazaadenosine, an inhibitor of S-adenosylhomocysteine hydrolase with a Ki of 3.9 μM, exhibits anti-inflammatory, anti-proliferative, and anti-HIV activity.Fórmula:C11H14N4O4Pureza:98%Forma y color:SolidPeso molecular:266.25ALLM
CAS:<p>ALLM (Calpain inhibitor II), a potent calpain and cathepsin protease inhibitor, not only prevents neuronal cell death but also enhances chronic neurological function following spinal cord injury (SCI)[1][2].</p>Fórmula:C19H35N3O4SPureza:98%Forma y color:White PowderPeso molecular:401.56ABT-072 potassium trihydrate
CAS:ABT-072, also known as potassium trihydrate, is a highly effective non-nucleoside inhibitor of the HCV NS5B polymerase, administered orally. This compound exhibits potent activity against HCV GT1a (with an EC50 of 1 nM) and HCV GT1b (with an EC50 of 0.3 nM).Fórmula:C24H32KN3O8SForma y color:SolidPeso molecular:561.69IPN60090 dihydrochloride
CAS:IPN-60090 dihydrochloride is a potent and specific inhibitor of glutaminase 1 (GLS1) with a remarkable inhibition constant (IC50) of 31 nM. It does not exhibit any inhibitory activity against GLS-2. Furthermore, IPN-60090 dihydrochloride possesses outstanding physicochemical properties and pharmacokinetic characteristics in vivo. Therefore, it is a valuable compound for researching solid tumors, including lung and ovarian cancers.Fórmula:C24H29Cl2F3N8O3Forma y color:SolidPeso molecular:605.44Oxindole
CAS:<p>Oxindole (Indolin-2-one) is an aromatic heterocyclic building block. 2-indolinone derivatives have become lead compounds in the research of kinase inhibitors.Oxindole structure has been used in receptor tyrosine kinases (RTKs) inhibitors such as SU4984 and intedanib, the RTK family represents an important therapeutic target for anti-cancer drug development.</p>Fórmula:C8H7NOPureza:99.34%Forma y color:Off-White Crystalline PowderPeso molecular:133.15Butabindide oxalate
CAS:<p>CCK-inactivating serine protease (tripeptidyl peptidase II) inhibitor</p>Fórmula:C19H27N3O6Pureza:98%Forma y color:SolidPeso molecular:393.43Davelizomib
CAS:<p>Davelizomib is a proteasome inhibitor that exhibits antineoplastic activity [1].</p>Fórmula:C21H26BF2N3O7Pureza:98%Forma y color:SolidPeso molecular:481.25
