Proteasas / Proteasoma
Los inhibidores de proteasas y proteasomas son compuestos que bloquean la actividad de las proteasas y del proteasoma, que están involucrados en la degradación y renovación de proteínas. Estos inhibidores son vitales para estudiar la regulación de la homeostasis proteica, el control del ciclo celular y la apoptosis. Los inhibidores de proteasas y proteasomas también se utilizan en el tratamiento de enfermedades como el cáncer, donde la degradación anormal de proteínas desempeña un papel en la progresión de la enfermedad. Al inhibir las proteasas o el proteasoma, estos compuestos pueden inducir la muerte celular en células cancerosas y son herramientas esenciales tanto en la investigación básica como en el desarrollo terapéutico. En CymitQuimica, ofrecemos una amplia gama de inhibidores de proteasas y proteasomas de alta calidad para apoyar su investigación en bioquímica, biología celular y desarrollo de fármacos.
Subcategorías de "Proteasas / Proteasoma"
- Acetil-CoA Carboxilasa(34 productos)
- Cisteína proteasa(96 productos)
- DPP-4(20 productos)
- Glutaminasa(40 productos)
- Proteasa del VIH(449 productos)
- PAI-1(25 productos)
- Inhibidores de la proteasa(50 productos)
- Receptor activado por proteasa(53 productos)
- Proteasoma(94 productos)
- Serina proteasa(50 productos)
- p97(14 productos)
Mostrar 3 subcategorías más
Se han encontrado 1044 productos de "Proteasas / Proteasoma"
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NS5A-IN-2
CAS:<p>NS5A-IN-2, a potent inhibitor, is highly effective against HCV 1b and shows increased activity for GT 3a with good metabolic stability.</p>Fórmula:C46H45N7O7Pureza:98%Forma y color:SolidPeso molecular:807.89DCLK1-IN-2
CAS:<p>DCLK1-IN-2 (Compound I-5) is a potent inhibitor of DCLK1, exhibiting an IC50 of 171.3 nM, and demonstrates significant antiproliferative effects on SW1990 cell</p>Fórmula:C26H32N8O3SForma y color:SolidPeso molecular:536.65MDL-101146, (R)-
CAS:<p>MDL-101146, (R)- is an effective orally active inhibitor of human neutrophil elastase.</p>Fórmula:C29H37F5N4O6Pureza:98%Forma y color:SolidPeso molecular:632.62HIV-1 protease-IN-9
CAS:<p>HIV-1 protease-IN-9 (compound 5b), a potent HIV-1 protease inhibitor, exhibits strong antiviral efficacy with a dissociation constant (K_i) of 0.028 nM and a</p>Fórmula:C37H41N7O4SPureza:98%Forma y color:SolidPeso molecular:679.83Kallikrein-IN-2
CAS:<p>Kallikrein-IN-2 (compound 1) is an inhibitor of the kinin-releasing enzyme Kallikrein.</p>Fórmula:C28H25F3N4O4Forma y color:SolidPeso molecular:538.52Z-DEVD-CMK
CAS:<p>Z-DEVD-CMK irreversibly inhibits various cathepsins in vitro [1].</p>Fórmula:C27H35ClN4O12Forma y color:SolidPeso molecular:643.04Cyclotheonellazole A
CAS:<p>Cyclotheonellazole A inhibits elastase (IC50=0.034nM) & chymotrypsin (IC50=0.62nM), a natural macrocyclic peptide.</p>Fórmula:C44H54N9NaO14S2Forma y color:SolidPeso molecular:1020.07MK-3281
CAS:<p>MK-3281: Oral, potent HCV NS5B inhibitor with promising properties and efficacy in replication trials, suitable for clinical use.</p>Fórmula:C29H37N3O3Forma y color:SolidPeso molecular:475.62L-689502
CAS:<p>L-689502 is a potent HIV-l protease inhibitor (IC50: 1 nM).</p>Fórmula:C39H51N3O7Pureza:98%Forma y color:SolidPeso molecular:673.84TP0556351
CAS:<p>TP0556351: potent MMP2 inhibitor with 0.2 nM IC50, reduces collagen in pulmonary fibrosis mice.</p>Fórmula:C50H70N10O16Pureza:98%Forma y color:SolidPeso molecular:1067.15GSK-625433
CAS:<p>GSK-625433: Homochiral inhibitor blocks HCV genotypes 1a/1b polymerase.</p>Fórmula:C26H32N4O5SForma y color:SolidPeso molecular:512.62AA74-1
CAS:<p>AA74-1 is a potent, selective APEH inhibitor that significantly enhances T-cell proliferation by inhibiting APEH activity [1].</p>Fórmula:C16H28N4O2Pureza:98%Forma y color:SolidPeso molecular:308.42Petesicatib
CAS:<p>Petesicatib is an inhibitor of cathepsin S. Petesicatib used in the research of immune diseases.</p>Fórmula:C25H23F6N5O4SPureza:99.76%Forma y color:SolidPeso molecular:603.54Cipemastat
CAS:<p>Cipemastat is a competitive inhibitor of human collagenases 1, 2, and 3 (Kis: 3.0, 4.4, and 3.4 nM).</p>Fórmula:C22H36N4O5Pureza:98%Forma y color:SolidPeso molecular:436.55Cathepsin K inhibitor 3
CAS:<p>Cathepsin K inhibitor 3: Selective, IC50 of 0.5 nM, good pharmacokinetics, potential for OA research.</p>Fórmula:C30H31FN4O4SForma y color:SolidPeso molecular:562.65MeOSuc-AAPV-CMK
CAS:<p>MeOSuc-AAPV-CMK (Elastase Inhibitor III) serves as an inhibitor of elastase, as well as cathepsin G and proteinase 3, and impedes leukocyte elastase-mediated</p>Fórmula:C22H35ClN4O7Forma y color:SolidPeso molecular:502.99FK706
CAS:<p>FK706, a human neutrophil elastase inhibitor (IC50: 83 nM, Ki: 4.2 nM), also blocks mouse and porcine elastases. Anti-inflammatory.</p>Fórmula:C26H33F3N4NaO7Forma y color:SolidPeso molecular:593.556XL-784
CAS:<p>XL-784 is a selective MMP inhibitor with low IC50s for MMP-1,2,3,8,9,13, modulating extracellular matrix remodeling, tumor invasion, and metastasis in cancer.</p>Fórmula:C42H42Cl2F4MgN6O16S2Pureza:98%Forma y color:SolidPeso molecular:1122.15Phe-Pro-Ala-pNA
CAS:<p>Phe-Pro-Ala-pNA is a chromogenic substrate utilized for assessing tripeptidyl peptidase activity.</p>Fórmula:C23H27N5O5Forma y color:SolidPeso molecular:453.49Atecegatran metoxil
CAS:<p>Atecegatran Metoxil (AZD0837), an oral thrombin inhibitor in development for stroke prevention in atrial fibrillation, is well-tolerated with favorable PK.</p>Fórmula:C22H23ClF2N4O5Forma y color:SolidPeso molecular:496.89MMP-7-IN-3
CAS:<p>MMP-7-IN-3 (compound 15) is a potent and selective MMP-7 inhibitor, inhibiting renal fibrosis in a unilateral ureteral obstruction mouse model.</p>Fórmula:C34H43ClF3N7O9SPureza:99.915%Forma y color:SolidPeso molecular:818.26Thrombin inhibitor 1
CAS:<p>Thrombin inhibitor 1 is a potent inhibitor of thrombin (Ki: 0.66 nM, 2xaPTT=0.43 μM).</p>Fórmula:C22H20Cl2F2N4O3Pureza:98%Forma y color:SolidPeso molecular:497.32Collagen proline hydroxylase inhibitor
CAS:<p>Collagen proline hydroxylase inhibitor is an inhibitor collagen proline hydroxylase and useful for antifibrotic proliferative agents.</p>Fórmula:C18H18N4O4Pureza:98%Forma y color:SolidPeso molecular:354.36Ro 31-9790
CAS:<p>Ro 31-9790 is a synthetic inhibitor of metalloproteinase (MMP).</p>Fórmula:C15H29N3O4Pureza:98%Forma y color:SolidPeso molecular:315.41Beclabuvir HCl
CAS:<p>Beclabuvir (BMS-791325) is an HCV inhibitor targeting NS5B polymerase with sub-28 nM potency for genotypes 1, 3, 4, 5.</p>Fórmula:C36H46ClN5O5SForma y color:SolidPeso molecular:696.3Azt-pmap
CAS:<p>AZT-PMPA, an aryl phosphate derivative of AZT and a nucleoside analogue, demonstrates anti-HIV activity[1].</p>Fórmula:C20H25N6O8PPureza:98%Forma y color:SolidPeso molecular:508.42HCV-IN-44
CAS:<p>HCV-IN-44 (compound 28) is an inhibitor of the HCV NS5B protein, efficacious in suppressing HCV virus replication and useful for researching HCV infection [1].</p>Fórmula:C24H26FN3O5SForma y color:SolidPeso molecular:487.54Paltimatrectinib
CAS:<p>Paltimatrectinib (PBI-200) is a tyrosine kinase inhibitor with anticancer activity, and is used in the study of bladder, breast, and colorectal cancers.</p>Fórmula:C20H15F5N6Pureza:99.96%Forma y color:SolidPeso molecular:434.37Proteasome β2c/i-IN-1
CAS:<p>Proteasome β2c/i-IN-1 (compound 37) serves as a selective inhibitor targeting the β2c and β2i subunits of the human proteasome [1].</p>Fórmula:C32H48N4O7Pureza:98%Forma y color:SolidPeso molecular:600.75Proteasome-IN-4
<p>Proteasome-IN-4, a potent non-covalent inhibitor (IC50=8.39nM), halts cancer cell growth, useful for oncology studies.</p>Fórmula:C44H58N6O5Forma y color:SolidPeso molecular:750.97KB-R7785
CAS:<p>KB-R7785 is a novel ADAM12/MMP inhibitor improving heart function and insulin sensitivity by blocking HB-EGF and TNF-alpha.</p>Fórmula:C18H27N3O4Forma y color:SolidPeso molecular:349.42NCI-B16
CAS:<p>NCI-B16 is a small-molecule RNA binder that inhibits HCV (hepatitis C virus) replication [1].</p>Fórmula:C27H26N8O4Forma y color:SolidPeso molecular:526.55Z-PDLDA-NHOH
CAS:<p>Z-PDLDA-NHOH is a potent, specific vertebrate collagenase inhibitor [1].</p>Fórmula:C22H32N4O6Forma y color:SolidPeso molecular:448.51Cathepsin Inhibitor 2
CAS:<p>Cathepsin Inhibitor 2 is a potent Cathepsin S inhibitor (Ki: <20 nM).</p>Fórmula:C19H21F6N3OPureza:98%Forma y color:SolidPeso molecular:421.38Mergetpa
CAS:<p>Mergetpa, a carboxypeptidase inhibitor, impedes the conversion of kinins and B2 receptor antagonists into metabolites devoid of the C-terminal arginine [1].</p>Fórmula:C7H15N3O2S2Pureza:98%Forma y color:SolidPeso molecular:237.34Ecallantide
CAS:<p>Ecallantide (DX-88) is a recombinant inhibitor specifically targeting plasma kallikrein, which serves to impede the synthesis of bradykinin.</p>Fórmula:C305H448N88O91S8Forma y color:SolidPeso molecular:7059.88ONO 4817
CAS:ONO-4817 suppresses MMPs, limiting plaque progression and aortic hyperplasia in hyperlipidemic rabbits.Fórmula:C22H28N2O6Forma y color:SolidPeso molecular:416.47Dim16
CAS:<p>Dim16, a dual inhibitor of PCSK9/HMG-CoAR, demonstrates potent activity with an IC50 of 19 nM against PCSK9 and significantly impedes PCSK9-LDLR interaction</p>Fórmula:C29H38IN5Forma y color:SolidPeso molecular:583.55GS-6620
CAS:<p>GS-6620 is a HCV nonstructural protein 5B (NS5B) inhibitor.</p>Fórmula:C29H37N6O9PForma y color:SolidPeso molecular:644.61LU-002i
CAS:<p>LU-002i is a selective inhibitor targeting the human proteasome subunits β2c and β2i, demonstrating an inhibitory concentration (IC50) of 220 nM for β2i [1].</p>Fórmula:C35H52N4O7Pureza:98%Forma y color:SolidPeso molecular:640.81AZD-7295
CAS:<p>AZD-7295 (A-689) is an NS5A inhibitor that may be used to treat HCV infection.</p>Fórmula:C32H35F3N4O5SForma y color:SolidPeso molecular:644.7SSR 69071
CAS:<p>SSR69071: selective neutrophil elastase inhibitor, stronger for humans (Ki=0.0168 nM), may treat COPD, asthma, and reduce heart injury.</p>Fórmula:C27H32N4O7SForma y color:SolidPeso molecular:556.63Proteasome-IN-5
CAS:<p>Proteasome-IN-5, also known as compound 5, acts as a proteasome inhibitor [1].</p>Fórmula:C20H30BN5O7Pureza:98%Forma y color:SolidPeso molecular:463.29PTC725
CAS:<p>PTC725 is a selective HCV 1b replicons inhibitor. It has been shown to target the nonstructural protein 4B.</p>Fórmula:C23H18F4N6O2SPureza:98%Forma y color:SolidPeso molecular:518.49EP1013
CAS:<p>EP1013 is a broad-spectrum selective inhibitor of Caspase used in the study of type 1 diabetes.</p>Fórmula:C18H23FN2O6Pureza:98%Forma y color:SolidPeso molecular:382.38HIV-1 protease-IN-7
CAS:<p>HIV-1 protease-IN-7 (compound 16) is an orally active inhibitor of HIV-1 protease, exhibiting an IC50 of 3.52 nM and an EC50 of 37 nM [1].</p>Fórmula:C68H104N10O12SPureza:98%Forma y color:SolidPeso molecular:1285.68I-XW-053
CAS:<p>I-XW-053 is an inhibitor of capsid targeted HIV-1 replication using the hybrid structure based method to block the interface between CA N-terminal domains (NTD-</p>Fórmula:C22H16N2O2Pureza:99.05%Forma y color:SolidPeso molecular:340.37Neurodegenerative Disorder-Targeting Compound 1
CAS:<p>Neurodegenerative Disorder-Targeting Compound 1 is an inhibitor of calpain [1].</p>Fórmula:C28H28N4O4Pureza:98%Forma y color:SolidPeso molecular:484.55HIV-1 protease-IN-12
CAS:<p>HIV-1 protease-IN-12 (compound 35b) serves as a potent inhibitor of HIV-1 protease, exhibiting an IC50 value of 0.51 nM, and demonstrates efficacy against drug-</p>Fórmula:C25H35N3O5SPureza:98%Forma y color:SolidPeso molecular:489.63MMP-145
CAS:<p>MMP-145 is used as a protease inhibitor.</p>Fórmula:C20H20N2O7SPureza:98%Forma y color:SolidPeso molecular:432.45
