Proteasas / Proteasoma
Los inhibidores de proteasas y proteasomas son compuestos que bloquean la actividad de las proteasas y del proteasoma, que están involucrados en la degradación y renovación de proteínas. Estos inhibidores son vitales para estudiar la regulación de la homeostasis proteica, el control del ciclo celular y la apoptosis. Los inhibidores de proteasas y proteasomas también se utilizan en el tratamiento de enfermedades como el cáncer, donde la degradación anormal de proteínas desempeña un papel en la progresión de la enfermedad. Al inhibir las proteasas o el proteasoma, estos compuestos pueden inducir la muerte celular en células cancerosas y son herramientas esenciales tanto en la investigación básica como en el desarrollo terapéutico. En CymitQuimica, ofrecemos una amplia gama de inhibidores de proteasas y proteasomas de alta calidad para apoyar su investigación en bioquímica, biología celular y desarrollo de fármacos.
Subcategorías de "Proteasas / Proteasoma"
- Acetil-CoA Carboxilasa(34 productos)
- Cisteína proteasa(96 productos)
- DPP-4(20 productos)
- Glutaminasa(40 productos)
- Proteasa del VIH(449 productos)
- PAI-1(25 productos)
- Inhibidores de la proteasa(50 productos)
- Receptor activado por proteasa(53 productos)
- Proteasoma(94 productos)
- Serina proteasa(50 productos)
- p97(14 productos)
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Se han encontrado 1044 productos de "Proteasas / Proteasoma"
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GCPII-IN-1
CAS:<p>GCPII-IN-1, a potent PSMA inhibitor, binds with 44.3 nM affinity.</p>Fórmula:C12H21N3O7Forma y color:SolidPeso molecular:319.314AL-611
CAS:<p>AL-611 is an HCV NS5B polymerase inhibitor ( EC 50 = 5 nM).</p>Fórmula:C25H33F2N6O8PForma y color:SolidPeso molecular:614.544Radalbuvir
CAS:<p>Radalbuvir (GS-9669) is an investigational antiviral agent for the treatment of hepatitis C virus (HCV) infection as an NS5B inhibitor.</p>Fórmula:C30H41NO6SForma y color:SolidPeso molecular:543.71Rivulariapeptolides 1155
<p>Rivulariapeptolides 1155 inhibits chymotrypsin (41.84 nM), elastase (4.94 nM), and proteinase K (56.54 nM).</p>Fórmula:C59H81N9O15Forma y color:SolidPeso molecular:1156.33Recombinant Proteinase K
Recombinant Proteinase K: serine protease, cleaves carboxy-terminus peptides, digests proteins, purifies nucleic acids.Forma y color:SolidGSK2336805
CAS:<p>GSK-2336805, an HCV NS5A inhibitor, is effective against genotypes 1, 4, 5, and some of 6.</p>Fórmula:C42H52N8O8Forma y color:SolidPeso molecular:796.91Leptosphaerodione
CAS:Leptosphaerodione from Remotididymella sp.: a potent UPS inhibitor with 3.2 μM IC50 in HeLa cells; anti-tumor.Fórmula:C21H22O5Forma y color:SolidPeso molecular:354.4Histargin
CAS:<p>Histargin is an enzyme inhibitor separated from Streptomyces roseoviridis.</p>Fórmula:C14H25N7O4Forma y color:SolidPeso molecular:355.39Proteasome-IN-7
<p>Proteasome-IN-7 (Compound 6f) is a macrolactam-based epoxyketone proteasome inhibitor with an IC50 value of 37.92 nM against the 20S proteasome ChT-L subunit. It exhibits potent antiproliferative effects on multiple myeloma, acute lymphoblastic leukemia, and non-small cell lung cancer.</p>Fórmula:C48H56N6O10SForma y color:SolidPeso molecular:909.06Peptide 74
CAS:<p>Peptide 74 is a synthetic peptide. It also inhibits the activated form of this enzyme.</p>Fórmula:C62H107N23O20S2Pureza:98%Forma y color:SolidPeso molecular:1558.79α 1 Antichymotrypsin, Human Plasma
CAS:<p>Alpha 1 Antichymotrypsin, Human Plasma is an inhibitor of serine proteases. This compound is present in amyloid lesions associated with Alzheimer's disease and can be utilized in Alzheimer's research.</p>Forma y color:SolidAPC-6860
CAS:<p>APC-6860, a serine protease inhibitor, targets multiple enzymes; most potent against human urokinase (Ki: 0.1 µM). Used in cancer research.</p>Fórmula:C9H7IN2SForma y color:SolidPeso molecular:302.13PSI-7409
CAS:<p>PSI-7409 is the active 5'-triphosphate metabolite of Sofosbuvir (PSI-7977).</p>Fórmula:C10H16FN2O14P3Pureza:98%Forma y color:SolidPeso molecular:500.16AMG-222
CAS:<p>AMG-222 (ALS-2-0426, ALS-20426) is a DPP-4 inhibitor and may be used in the treatment of type 2 diabetes.</p>Fórmula:C32H39N9O3Forma y color:SolidPeso molecular:597.71Berotralstat
CAS:<p>Berotralstat (BCX7353) is an oral, low-toxicity, specific kallikrein inhibitor for hereditary angioedema research, blocking bradykinin release.</p>Fórmula:C30H26F4N6OForma y color:SolidPeso molecular:562.56Ac-VDQQD-pNA
CAS:<p>Ac-VDQQD-pNA serves as a substrate for Caspase 2, which cleaves it to yield the yellow compound pNA (p-nitroaniline).</p>Fórmula:C31H43N9O14Forma y color:SolidPeso molecular:765.73Sitagliptin fenilalanil hydrochloride
CAS:<p>Sitagliptin phenylalanine hydrochloride, a dipeptidyl peptidase-4 (DPP-4) inhibitor [1], is a chemical compound utilized in medical applications.</p>Fórmula:C25H25ClF6N6O2Forma y color:SolidPeso molecular:590.95PS 915
CAS:<p>PS 915 is a substrate for colorimetric assay. It was used for plasma antithrombin.</p>Fórmula:C27H36ClN7O6Pureza:98%Forma y color:SolidPeso molecular:590.08Fotagliptin benzoate
CAS:<p>Fotagliptin benzoate, a DPP-4 inhibitor (IC50=2.27 nM), is safe in rats/dogs, useful for Type 2 diabetes research.</p>Fórmula:C24H25FN6O3Forma y color:SolidPeso molecular:464.49HCV-IN-41
CAS:<p>HCV-IN-41: potent HCV inhibitor; EC50 - 0.006762 nM (1b), 5.183 nM (2a), 1.365 nM (3a), 142.2 nM (4a); hinders RNA replication.</p>Fórmula:C48H56N6O8Forma y color:SolidPeso molecular:844.99Tyrosinase-IN-34
<p>Tyrosinase-IN-34 (compound 5a), a human tyrosinase inhibitor (IC 50: 3.5 μM), shows promise in regulating melanogenesis and pigmentation.</p>Fórmula:C19H14BrClN4OForma y color:SolidPeso molecular:429.7Histatin 5 (TFA)(115966-68-2,free)
<p>Histatin 5 (TFA)(115966-68-2,free) (Histatin 5 (TFA)) inhibits the activity of the host matrix metalloproteinases MMP-2 and MMP-9 with IC50s of 0.57 and 0.25 μM</p>Fórmula:C135H196F3N51O35Pureza:98%Forma y color:SolidPeso molecular:3150.32NVP-DPP728 dihydrochloride
CAS:<p>NVP-DPP728 dihydrochloride is a potent, selective DPP-IV inhibitor with a Ki of 11 nM, useful in diabetes research.</p>Fórmula:C15H20Cl2N6OForma y color:SolidPeso molecular:371.27Stevia Powder
<p>Stevia Powder, a natural sweetener, possesses antioxidant properties. It regulates antifibrotic pathways in cirrhotic rats, demonstrated by a reduction in hepatic stellate cells and decreased expression of matrix metalloproteinases MMP2 and MMP13. Furthermore, it increases the antifibrotic molecule Smad7, which helps prevent the elevation of serum necrosis and bile retention markers, thereby inhibiting the progression of liver fibrosis.</p>Forma y color:Odour SolidBefovacimab
CAS:<p>Befovacimab, a human IgG2 antibody, targets TFPI for hemophilia A/B research.</p>Forma y color:LiquidCP-346086 dihydrate
CAS:<p>CP-346086 dihydrate is a strong oral MTP inhibitor with 2.0 nM IC50, reducing cholesterol and triglycerides in vivo.</p>Fórmula:C26H26F3N5O3Forma y color:SolidPeso molecular:513.521Pseudostellarin G
CAS:<p>Pseudostellarin G, a naturally occurring cyclo-octapeptide, exhibits inhibitory activity against tyrosinase and suppresses melanin production.</p>Fórmula:C42H56N8O9Forma y color:SolidPeso molecular:816.94MK-6169
CAS:<p>MK-6169 is an effective Pan-Genotype Hepatitis C Virus NS5A inhibitor. It also has Optimized Activity against Common Resistance-Associated Substitutions.</p>Fórmula:C54H62FN9O8SPureza:98%Forma y color:SolidPeso molecular:1016.2KKI-5
CAS:<p>KKI 5: Serine protease inhibitor, blocks kallikrein & plasmin, potential for cancer therapy & angioedema treatment.</p>Fórmula:C35H55N11O9Pureza:98%Forma y color:SolidPeso molecular:773.88Dutogliptin
CAS:<p>Dutogliptin (PHX-1149 free base) is an oral, effective and selective dipeptide-peptide-4 (DPP4) inhibitor for the treatment of type 2 diabetes mellitus.</p>Fórmula:C10H20BN3O3Pureza:98%Forma y color:SolidPeso molecular:241.10CL 82198 hydrochloride
CAS:<p>CL 82198 hydrochloride selectively inhibits MMP-13, not MMP-1/9/TACE, and blocks HP75 invasion and neurotoxicity in zebrafish.</p>Fórmula:C17H23ClN2O3Forma y color:SolidPeso molecular:338.83Acetyl-Calpastatin(184-210)(human)
CAS:<p>Calpain inhibitor, Ki 0.2 nM for calpain I/II, doesn't affect papain/trypsin/cat L. Raises Aβ42, Aβ40 secretion & Aβ42/Aβ40 ratio.</p>Fórmula:C142H230N36O44SPureza:98%Forma y color:SolidPeso molecular:3177.65Ecallantide TFA
<p>Ecallantide (DX-88) TFA, a specific recombinant plasma kallikrein inhibitor, directly inhibits bradykinin production and is indicated for the prevention of</p>Forma y color:Odour SolidAP-C2
CAS:<p>AP-C2 is a potent small molecule guanosine 3',5'-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) inhibitor with a pIC50 of 5.2 for cGKII.</p>Fórmula:C18H16N4SPureza:99.87%Forma y color:SoildPeso molecular:320.41C-telopeptide
CAS:<p>C-telopeptide from type I collagen is released during bone resorption; it correlates with bone mineral density.</p>Fórmula:C34H56N14O13Pureza:98%Forma y color:SolidPeso molecular:868.9Tyrosinase-IN-32
<p>Tyrosinase-IN-32 (compound 11), a hydroxamate-based alkaloid extracted from black pepper (Piper nigrum L.), functions as an inhibitor of mushroom tyrosinase. In addition to its inhibitory properties, it exhibits antioxidant activity.</p>Fórmula:C15H19NO3Forma y color:SolidPeso molecular:261.32Anticancer agent 114
<p>Anticancer agent 114: oral dipeptide boronic acid, proteasome inhibitor, IC 50 = 2.2 nM, halts RPMI-8226 cell growth, for multiple myeloma research.</p>Fórmula:C28H33BF6N2O7Forma y color:SolidPeso molecular:634.37Elastatinal
CAS:<p>Elastatinal is an elastase inhibitor. It is found in culture filtrates of various species of actinomyces.</p>Fórmula:C21H36N8O7Forma y color:Yellowish SolidPeso molecular:512.56Ac-DEMEEC-OH
CAS:<p>Ac-DEMEEC-OH is a competitive inhibitor of the HCV NS3 protease with a Ki of 0.6 µM.</p>Fórmula:C29H44N6O16S2Forma y color:SolidPeso molecular:796.82HIV-1 TAT (48-60) Acetate
<p>Lilotomab (HH1) is a murine anti-CD37 antibody that can be used to synthesize anti-CD37 antibody-radionuclide couplings.</p>Fórmula:C72H135N35O18Pureza:99.93%Forma y color:SoildPeso molecular:1779.07EP 171
CAS:<p>EP 171 is a potent agonist of TP-receptors.</p>Fórmula:C23H29FO5Forma y color:SolidPeso molecular:404.47STK33-IN-1
CAS:<p>STK33-IN-1 (compound 1) is a STK33 inhibitor, with an IC 50 of 7 nM.</p>Fórmula:C24H27N7O2Forma y color:SolidPeso molecular:445.527GSK2818713
CAS:<p>GSK2818713 is a novel Hepatitis C NS5A replication complex inhibitor.</p>Fórmula:C46H56N8O8Forma y color:SolidPeso molecular:849.002BMS-767778
CAS:<p>BMS-767778, a DPP-4 inhibitor, is used potentially for the treatment of type 2 diabetes.</p>Fórmula:C19H20Cl2N4O2Forma y color:SolidPeso molecular:407.29Linagliptin Methyldimer
CAS:<p>Linagliptin Methyldimer is a potent dipeptidyl peptidase IV inhibitor, IC50=6 pM.</p>Fórmula:C50H56N16O4Pureza:97.23%Forma y color:SolidPeso molecular:945.08RXP470
CAS:<p>RXP470 is a potent and selective MMP-12 inhibitor (Ki 0.24 nM).</p>Fórmula:C35H35BrClN4O10PForma y color:SolidPeso molecular:818Plasma kallikrein-IN-1
CAS:<p>Plasma kallikrein-IN-1 is a PKK inhibitor with an IC 50 value of 0.5 nM.</p>Fórmula:C23H25F2N7OForma y color:SolidPeso molecular:453.498FiVe1
CAS:<p>FiVe1 is a vimentin-binding compound that disrupts mitosis in cancer cells, causing cell death, with an IC50 of 234 nM in FOXC2-HMLER.</p>Fórmula:C18H16Cl2N4Pureza:99.67%Forma y color:SolidPeso molecular:359.25Paritaprevir dihydrate
CAS:<p>Paritaprevir dihydrate: potent oral HCV NS3/4A inhibitor (EC50: 0.21-1 nM), SARS-CoV-3CL blocker (IC50: 1.31 μM), metabolized by CYP3A, boosted by Ritonavir.</p>Fórmula:C40H47N7O9SForma y color:SolidPeso molecular:801.91CTTHWGFTLC, CYCLIC
CAS:<p>CTT Gelatinase Inhibitor peptide blocks MMP-2/9, hindering cancer by stopping tumor growth.</p>Fórmula:C52H71N13O14S2Pureza:98%Forma y color:SolidPeso molecular:1166.33
