Proteasas / Proteasoma
Los inhibidores de proteasas y proteasomas son compuestos que bloquean la actividad de las proteasas y del proteasoma, que están involucrados en la degradación y renovación de proteínas. Estos inhibidores son vitales para estudiar la regulación de la homeostasis proteica, el control del ciclo celular y la apoptosis. Los inhibidores de proteasas y proteasomas también se utilizan en el tratamiento de enfermedades como el cáncer, donde la degradación anormal de proteínas desempeña un papel en la progresión de la enfermedad. Al inhibir las proteasas o el proteasoma, estos compuestos pueden inducir la muerte celular en células cancerosas y son herramientas esenciales tanto en la investigación básica como en el desarrollo terapéutico. En CymitQuimica, ofrecemos una amplia gama de inhibidores de proteasas y proteasomas de alta calidad para apoyar su investigación en bioquímica, biología celular y desarrollo de fármacos.
Subcategorías de "Proteasas / Proteasoma"
- Acetil-CoA Carboxilasa(34 productos)
- Cisteína proteasa(96 productos)
- DPP-4(20 productos)
- Glutaminasa(40 productos)
- Proteasa del VIH(449 productos)
- PAI-1(25 productos)
- Inhibidores de la proteasa(50 productos)
- Receptor activado por proteasa(53 productos)
- Proteasoma(94 productos)
- Serina proteasa(50 productos)
- p97(14 productos)
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Se han encontrado 1044 productos de "Proteasas / Proteasoma"
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Sucunamostat
CAS:<p>Sucunamostat is an L-aspartic acid enteropeptidase inhibitor.</p>Fórmula:C22H22N4O8Forma y color:SolidPeso molecular:470.438DPP-4-IN-14
<p>DPP-4-IN-14 (compound 30) is an inhibitor of DPP-4, with an IC50 value of 12.82 nM.</p>Fórmula:C33H27N7O3Forma y color:SolidPeso molecular:569.613Sulodexide
CAS:<p>Sulodexide is an orally administered combination of glycosaminoglycans, consisting of low molecular weight heparin (80%) and dermatan sulfate (20%). It demonstrates antithrombotic properties by interacting with antithrombin III (AT III) and heparin cofactor II (HC II), and by inhibiting thrombin formation. Additionally, sulodexide enhances profibrinolytic activity by releasing tissue plasminogen activator (tPA). It also offers endothelial protection, possesses anti-inflammatory effects, and alleviates chronic venous disease.</p>Forma y color:SolidTWH106
<p>TWH106 is an inhibitor of the cyclophilin (Cyp) enzyme, exhibiting strong affinity for CypA and CypB with dissociation constants (KD) of 53 nM and 139 nM, respectively. It effectively inhibits the replication of HIV and HCV, demonstrating antiviral activity.</p>Forma y color:Odour SolidApovincamine
CAS:<p>Apovincamine is a vinca alkaloid and a chemical precursor of Vinpocetine, which is a derivative of Vincamine with vasodilating activity.</p>Fórmula:C21H24N2O2Pureza:98%Forma y color:SolidPeso molecular:336.44GSK2818713
CAS:<p>GSK2818713 is a novel Hepatitis C NS5A replication complex inhibitor.</p>Fórmula:C46H56N8O8Forma y color:SolidPeso molecular:849.002Ecallantide TFA
<p>Ecallantide (DX-88) TFA, a specific recombinant plasma kallikrein inhibitor, directly inhibits bradykinin production and is indicated for the prevention of</p>Forma y color:Odour SolidChymotrypsinogen
CAS:<p>Chymotrypsinogen is an inactive precursor of Chymotrypsin . Chymotrypsin is a serine protease produced by the pancreas [1] [2] .</p>Forma y color:SolidHistatin 5
CAS:<p>Histatin 5, a human saliva peptide, blocks MMP-2 and MMP-9 at IC50s of 0.57/0.25 μM and kills fungi.</p>Fórmula:C133H195N51O33Pureza:98%Forma y color:SolidPeso molecular:3036.29MK-6169
CAS:<p>MK-6169 is an effective Pan-Genotype Hepatitis C Virus NS5A inhibitor. It also has Optimized Activity against Common Resistance-Associated Substitutions.</p>Fórmula:C54H62FN9O8SPureza:98%Forma y color:SolidPeso molecular:1016.2STK33-IN-1
CAS:<p>STK33-IN-1 (compound 1) is a STK33 inhibitor, with an IC 50 of 7 nM.</p>Fórmula:C24H27N7O2Forma y color:SolidPeso molecular:445.527PS 915
CAS:<p>PS 915 is a substrate for colorimetric assay. It was used for plasma antithrombin.</p>Fórmula:C27H36ClN7O6Pureza:98%Forma y color:SolidPeso molecular:590.08Elastatinal
CAS:<p>Elastatinal is an elastase inhibitor. It is found in culture filtrates of various species of actinomyces.</p>Fórmula:C21H36N8O7Forma y color:Yellowish SolidPeso molecular:512.56JC-10
CAS:<p>JC-10 is a potent inhibitor of metalloproteinases and is often used as a probe.</p>Fórmula:C25H29Cl2IN4Pureza:95%Forma y color:SolidPeso molecular:583.34Suc-AAP-Abu-pNA
CAS:<p>Suc-AAP-Abu-pNA is a specific substrate for pancreatic elastase (Km = 100 μM; Kcat/Km = 35,300 s-1 M-1 for rat pancreatic elastase; Km = 30 μM; Kcat/Km = 351,</p>Fórmula:C25H34N6O9Forma y color:SolidPeso molecular:562.57HIV-1 TAT (48-60) Acetate
<p>Lilotomab (HH1) is a murine anti-CD37 antibody that can be used to synthesize anti-CD37 antibody-radionuclide couplings.</p>Fórmula:C72H135N35O18Pureza:99.93%Forma y color:SoildPeso molecular:1779.07α 1 Antichymotrypsin, Human Plasma
CAS:<p>Alpha 1 Antichymotrypsin, Human Plasma is an inhibitor of serine proteases. This compound is present in amyloid lesions associated with Alzheimer's disease and can be utilized in Alzheimer's research.</p>Forma y color:SolidL-Methionine-DL-sulfoximine
CAS:<p>MSO blocks glutamine synthetase, impacts astroglia, and is used in convulsant research.</p>Fórmula:C5H12N2O3SPureza:99.56% - ≥98%Forma y color:White Crystalline PowderPeso molecular:180.23Paritaprevir dihydrate
CAS:<p>Paritaprevir dihydrate: potent oral HCV NS3/4A inhibitor (EC50: 0.21-1 nM), SARS-CoV-3CL blocker (IC50: 1.31 μM), metabolized by CYP3A, boosted by Ritonavir.</p>Fórmula:C40H47N7O9SForma y color:SolidPeso molecular:801.91Proteasome-IN-7
<p>Proteasome-IN-7 (Compound 6f) is a macrolactam-based epoxyketone proteasome inhibitor with an IC50 value of 37.92 nM against the 20S proteasome ChT-L subunit. It exhibits potent antiproliferative effects on multiple myeloma, acute lymphoblastic leukemia, and non-small cell lung cancer.</p>Fórmula:C48H56N6O10SForma y color:SolidPeso molecular:909.06Sofosbuvir impurity A
CAS:<p>Sofosbuvir impurity A is an diastereoisomer of Sofosbuvir. Sofosbuvir is anHCV RNA replication inhibitor ,with potent anti-hepatitis C virus activity.</p>Fórmula:C22H29FN3O9PPureza:98%Forma y color:SolidPeso molecular:529.45MMP-3 Inhibitor
CAS:<p>MMP-3 Inhibitor is a peptide matrix metalloproteinase-3 (MMP-3) inhibitor with a Ki value of 95 nM.MMP-3 inhibitor has anticancer and antitumor activity.</p>Fórmula:C27H46N10O9SPureza:98.87%Forma y color:SolidPeso molecular:686.78Fotagliptin
CAS:<p>Fotagliptin is a dipeptidyl peptidase IV inhibitor.</p>Fórmula:C17H19FN6OForma y color:SolidPeso molecular:342.37Carboxypeptidase C
CAS:<p>Carboxypeptidase C removes COOH-terminal amino acids and others in peptides for biochemical studies.</p>Forma y color:SolidSofosbuvir impurity H
<p>Sofosbuvir impurity H, an diastereoisomer of Sofosbuvir, is the impurity of Sofosbuvir.</p>Fórmula:C29H33FN3O10PPureza:98%Forma y color:SolidPeso molecular:633.56TAPI1 acetate
<p>TAPI1 acetate (TNF-α processing inhibitor-1) is a TACE (ADAM17) inhibitor that inhibits shedding of TNF-α cytokine receptors; MMP inhibitor .</p>Fórmula:C28H41N5O7Pureza:98.82% - 99.94%Forma y color:SolidPeso molecular:559.65Lonodelestat TFA
<p>Lonodelestat TFA, an oral peptide, selectively inhibits hNE, potentially aiding in CF research.</p>Fórmula:C73H112F3N15O21Forma y color:SolidPeso molecular:1592.75TMC647055 Choline salt
<p>TMC647055 choline salt is a selective and cell-permeating inhibitor of HCV NS5B (IC50: 34 nM).</p>Fórmula:C37H53N5O8SPureza:98%Forma y color:SolidPeso molecular:727.91Cathepsin C-IN-6
<p>Cathepsin C-IN-6 (compound 2), an E-64c-hydrazideas-derived inhibitor of cathepsin C, possesses anti-inflammatory properties and impedes neutrophil elastase</p>Fórmula:C24H35N5O4·xC2HF3O2Forma y color:SolidFFAGLDD TFA
<p>FFAGLDD TFA: MMP9 peptide for controlled DOX delivery to cytoplasm.</p>Fórmula:C39H50F3N7O14Pureza:98%Forma y color:SolidPeso molecular:897.85Tiprelestat
CAS:<p>Tiprelestat: strong inhibitor of human neutrophil elastase, anti-inflammatory, antimicrobial, used in inflammation/immune research.</p>Fórmula:C254H416N72O75S10Forma y color:SolidPeso molecular:5999.09Neutrophil elastase inhibitor 4
<p>Neutrophil elastase inhibitor 4 (compound 4f) is a competitive inhibitor of human neutrophil elastase (HNE) with IC50 of 42.30 nM and Ki of 8.04 nM.</p>Fórmula:C20H21N3O5Forma y color:SolidPeso molecular:383.4Rivulariapeptolides 1155
<p>Rivulariapeptolides 1155 inhibits chymotrypsin (41.84 nM), elastase (4.94 nM), and proteinase K (56.54 nM).</p>Fórmula:C59H81N9O15Forma y color:SolidPeso molecular:1156.33NS5A-IN-4
CAS:<p>NS5A-IN-4 (Compound 1.12) is a hepatitis C inhibitor effective against multiple genotypes, with IC50 values ranging from 1.2 to 2296 pM.</p>Fórmula:C47H48N8O6Forma y color:SolidPeso molecular:820.93Alisporivir
CAS:<p>Alisporivir (Debio-025) is a cyclophilin A inhibitor that disrupts the interaction between CypA and NS5A. HCV activity in vivo and in vitro.</p>Fórmula:C63H113N11O12Pureza:99.95%Forma y color:SolidPeso molecular:1216.64BMS 180742
CAS:<p>BMS 180742 is an exosite inhibitor of thrombin.</p>Fórmula:C67H93N11O22Pureza:98%Forma y color:SolidPeso molecular:1404.52Sofosbuvir impurity J
CAS:<p>Sofosbuvir impurity J is an diastereoisomer of Sofosbuvir.Sofosbuvir is an HCV RNA replication inhibitor, with potent anti-hepatitis C virus activity.</p>Fórmula:C22H30FN4O8PPureza:98%Forma y color:SolidPeso molecular:528.47Ac-PAL-AMC
CAS:<p>Ac-PAL-AMC is a β1i/LMP2-specific substrate that fluoresces when cleaved; useful for measuring immunoproteasome activity.</p>Fórmula:C26H34N4O6Forma y color:SolidPeso molecular:498.57Nostopeptin B
CAS:<p>Nostopeptin B is an inhibitor of elastase.</p>Fórmula:C46H70N8O12Forma y color:SolidPeso molecular:927.11Fibrinopeptide B, human
CAS:<p>Fibrinopeptide B (FPB) is produced during the cleavage of fibrinogen, by thrombin, to fibrin monomer.</p>Fórmula:C66H93N19O25Pureza:98%Forma y color:SolidPeso molecular:1552.56Calpain Inhibitor-1
CAS:<p>Calpain Inhibitor-1, a potent Calpain 1 blocker, has IC50 of 100 nM and Ki of 2.89 μM.</p>Fórmula:C19H17FN6O5SForma y color:SolidPeso molecular:460.44Dutogliptin tartrate
CAS:Dutogliptin tartrate is an effective and selective oral dipeptide-peptide-4 (DPP4) inhibitor for the treatment of type 2 diabetes mellitus.Fórmula:C14H26BN3O9Pureza:98%Forma y color:SolidPeso molecular:391.18GCPII-IN-1
CAS:<p>GCPII-IN-1, a potent PSMA inhibitor, binds with 44.3 nM affinity.</p>Fórmula:C12H21N3O7Forma y color:SolidPeso molecular:319.314PF 00356231
CAS:<p>PF 00356231 is a selectivity inhibitor MMP-12 and can be used in studies about the treatment of emphysema and chronic obstructive pulmonary disease (COPD).</p>Fórmula:C25H20N2O3SPureza:99.35%Forma y color:SolidPeso molecular:428.5Relacatib
CAS:<p>Relacatib (SB-462795) is a potent cathepsins K, L, V inhibitor with high affinity (Ki: 41-68 pM) and reduces bone resorption effectively.</p>Fórmula:C27H32N4O6SForma y color:SolidPeso molecular:540.64EP 171
CAS:<p>EP 171 is a potent agonist of TP-receptors.</p>Fórmula:C23H29FO5Forma y color:SolidPeso molecular:404.47CRA-2059 TFA
<p>CRA-2059 is a highly specific and selective tryptase inhibitor, with a Ki of 620 pM for recombinant human tryptase-β (rHTβ)[1][2].</p>Forma y color:SolidIchorcumab
CAS:<p>Ichorcumab (JNJ-375) is a fully human IgG4 antibody that targets thrombin. It binds to exosite 1 of thrombin, inhibiting substrate binding without affecting its catalytic activity. For isotype control, refer to HumanIgG1kappa, Isotype Control.</p>Forma y color:LiquidHIV-1 inhibitor-6
CAS:<p>HIV-1 inhibitor-6 (3-Pyridinecarboxamide, 1,4-dihydro-1-methyl-N-(5-nitro-1,2-benzisothiazol-3-yl)-4-oxo-) is a potent HIV-1 pre-mRNA selective splicing</p>Fórmula:C14H10N4O4SPureza:99.33%Forma y color:SolidPeso molecular:330.32HCV-IN-7 hydrochloride
CAS:<p>HCV-IN-7 hydrochloride: Oral, potent HCV NS5A inhibitor, pan-genotypic, IC50s 3-47 pM, good pharmacokinetics, favorable liver uptake.</p>Fórmula:C40H50Cl2N8O6SPureza:98%Forma y color:SolidPeso molecular:841.85
