Proteasas / Proteasoma
Los inhibidores de proteasas y proteasomas son compuestos que bloquean la actividad de las proteasas y del proteasoma, que están involucrados en la degradación y renovación de proteínas. Estos inhibidores son vitales para estudiar la regulación de la homeostasis proteica, el control del ciclo celular y la apoptosis. Los inhibidores de proteasas y proteasomas también se utilizan en el tratamiento de enfermedades como el cáncer, donde la degradación anormal de proteínas desempeña un papel en la progresión de la enfermedad. Al inhibir las proteasas o el proteasoma, estos compuestos pueden inducir la muerte celular en células cancerosas y son herramientas esenciales tanto en la investigación básica como en el desarrollo terapéutico. En CymitQuimica, ofrecemos una amplia gama de inhibidores de proteasas y proteasomas de alta calidad para apoyar su investigación en bioquímica, biología celular y desarrollo de fármacos.
Subcategorías de "Proteasas / Proteasoma"
- Acetil-CoA Carboxilasa(34 productos)
- Cisteína proteasa(96 productos)
- DPP-4(20 productos)
- Glutaminasa(40 productos)
- Proteasa del VIH(449 productos)
- PAI-1(25 productos)
- Inhibidores de la proteasa(50 productos)
- Receptor activado por proteasa(53 productos)
- Proteasoma(94 productos)
- Serina proteasa(50 productos)
- p97(14 productos)
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Se han encontrado 1044 productos de "Proteasas / Proteasoma"
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GLS-1-IN-1
<p>GLS-1-IN-1 (compound 1d) is a GLS-1 inhibitor that inhibits Hep G2, MCF 7 and MCF 10A cells.</p>Fórmula:C26H25FN4OSForma y color:SolidPeso molecular:460.57Cathepsin C-IN-3
<p>Cathepsin C-IN-3 is a potent inhibitor of histone C (IC50: 61.79 nM) and also inhibits THP-1 cells (IC50: 101.5 nM) and U937 cells (IC50: 86.5 nM).</p>Fórmula:C28H21F3N6OSForma y color:SolidPeso molecular:546.57Antiplatelet agent 3
CAS:<p>Antiplatelet agent 3 (Compound K-10) is a compound with antiplatelet aggregation activity, exhibiting IC50 values of 2.55, 3.22, and 2.09 mg/mL for platelet aggregation induced by ADP, AA, and COL, respectively. It holds potential for research in cardiovascular diseases.</p>Fórmula:C38H32N2O5Forma y color:SolidPeso molecular:596.671SCO-792
<p>SCO-792: potent, reversible oral enteropeptidase inhibitor, with slow in vitro dissociation and in vivo protein digestion blocking.</p>Fórmula:C22H22N4O8·xH2OForma y color:SolidKallikrein-IN-1
CAS:<p>Kallikrein-IN-1 (Formula A) is an inhibitor of the kinin-releasing enzyme Kallikrein.</p>Fórmula:C28H26FN5O4Forma y color:SolidPeso molecular:515.54CM-352
CAS:<p>CM-352 is a metalloproteinase inhibitor that reduces brain damage and improves functional recovery in rat models of cerebral hemorrhage.</p>Fórmula:C24H29N3O6SPureza:99.36%Forma y color:SolidPeso molecular:487.57Immunoproteasome activator 1
CAS:Immunoproteasome Activator 1 (compound A) is a selective immunoproteasome activator that enhances the presentation of individual MHC-I binding peptides by over 100 times. It binds to the proteasomal structural subunit PSMA1 and facilitates the association of the proteasome activators PA28α/β (PSME1/PSME2) with the immunoproteasome.Fórmula:C24H23N3O3Forma y color:SolidPeso molecular:401.46GSK-2878175
CAS:<p>GSK-2878175, a NS5B inhibitor, is used potentially for the treatment of HCV infection.</p>Fórmula:C27H23BClFN2O6SPureza:98%Forma y color:SolidPeso molecular:568.81Piceid 6″-O-azelaic acid ester
<p>Piceid 6″-O-azelaic acid ester exhibited strong intracellular tyrosinase inhibition and decolorization activity.</p>Fórmula:C24H36O10Forma y color:SolidPeso molecular:484.54IDX184
CAS:<p>IDX184 is a potent, orally active, targeted HCV polymerase inhibitor and nucleoside polymerase.IDX184 effectively inhibits HCV polymerase (IC50=0.31 μM, Ki=52.3</p>Fórmula:C25H35N6O9PSPureza:97.15%Forma y color:SolidPeso molecular:626.62JTK-109
CAS:<p>JTK-109 is an inhibitor of hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitor and inhibits G1b and G3a subgenomic replicons and recombinant enzymes.</p>Fórmula:C37H33ClFN3O4Pureza:98.48% - 99.68%Forma y color:SolidPeso molecular:638.13Vaniprevir
CAS:<p>Vaniprevir is a competitive HCV NS3/4A protease inhibitor, an antiviral(hepatitis C virus) drug that acts directly and blocks the viral replication process.</p>Fórmula:C38H55N5O9SPureza:97.41%Forma y color:SolidPeso molecular:757.94MIV-247
CAS:<p>MIV-247 is a cathepsin S inhibitor that attenuates mechanically abnormal pain in preclinical neuropathic pain models and can be used to study myocardial injury.</p>Fórmula:C17H24F3N3O4Pureza:99.27%Forma y color:SolidPeso molecular:391.39PD 151746
CAS:<p>PD151746: calpain inhibitor, Ki μ-calpain=0.26μM, Ki m-calpain=5.33μM; reduces oxLDL cytotoxicity.</p>Fórmula:C11H8FNO2SPureza:98.63% - ≥95%Forma y color:SolidPeso molecular:237.25Sebetralstat
CAS:<p>Sebetralstat (KVD900) is an inhibitor of plasma kallikrein and can be used in studies about metabolic diseases.</p>Fórmula:C26H26FN5O4Pureza:99.85%Forma y color:SolidPeso molecular:491.512,7,10,12-Tetraazatridecanoic acid, 4-hydroxy-12-methyl-9-(1-methylethyl)-13-[2-(1-methylethyl)-4-thiazolyl]-8,11-dioxo-3,6-bis(phenylmethyl)-, 5-thiazolylmethyl ester, (3S,4S,6S,9S)-
CAS:Fórmula:C37H48N6O5S2Pureza:≥98%Forma y color:SolidPeso molecular:720.9442MMP13-IN-2
CAS:<p>MMP13-IN-2 is a highly potent, selective, and orally active inhibitor of MMP-13. It demonstrates exceptional potency against MMP-13, with an IC50 value of 0.036 nM, and exhibits selectivities greater than 1,500-fold over MMP-1, 3, 7, 8, 9, 14, and TACE. Moreover, MMP13-IN-2 possesses the capability to effectively inhibit collagen release from cartilage in vitro. Consequently, MMP13-IN-2 holds great potential for advancing research on collagenase-related diseases.</p>Fórmula:C24H19FN6O4SForma y color:SolidPeso molecular:506.51IPN60090 dihydrochloride
CAS:<p>IPN-60090 dihydrochloride is a potent and specific inhibitor of glutaminase 1 (GLS1) with a remarkable inhibition constant (IC50) of 31 nM. It does not exhibit any inhibitory activity against GLS-2. Furthermore, IPN-60090 dihydrochloride possesses outstanding physicochemical properties and pharmacokinetic characteristics in vivo. Therefore, it is a valuable compound for researching solid tumors, including lung and ovarian cancers.</p>Fórmula:C24H29Cl2F3N8O3Forma y color:SolidPeso molecular:605.44ALLM
CAS:<p>ALLM (Calpain inhibitor II), a potent calpain and cathepsin protease inhibitor, not only prevents neuronal cell death but also enhances chronic neurological function following spinal cord injury (SCI)[1][2].</p>Fórmula:C19H35N3O4SPureza:98%Forma y color:White PowderPeso molecular:401.56ABT-072 potassium trihydrate
CAS:<p>ABT-072, also known as potassium trihydrate, is a highly effective non-nucleoside inhibitor of the HCV NS5B polymerase, administered orally. This compound exhibits potent activity against HCV GT1a (with an EC50 of 1 nM) and HCV GT1b (with an EC50 of 0.3 nM).</p>Fórmula:C24H32KN3O8SForma y color:SolidPeso molecular:561.69
