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Células madre y Derivados

Células madre y Derivados

Los inhibidores de células madre son compuestos que se dirigen específicamente a las vías de señalización y proteínas involucradas en el mantenimiento, diferenciación y proliferación de células madre. Estos inhibidores son cruciales para comprender la biología de las células madre y para desarrollar estrategias que permitan manipularlas con fines terapéuticos, como en la medicina regenerativa y el tratamiento del cáncer. Al controlar el destino de las células madre, estos inhibidores pueden ayudar a guiar la diferenciación de células madre en tipos celulares específicos o prevenir el crecimiento celular no deseado. En CymitQuimica, ofrecemos una selección de inhibidores de células madre de alta calidad para apoyar su investigación en biología de células madre, biología del desarrollo y medicina regenerativa.

Subcategorías de "Células madre y Derivados"

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Se han encontrado 694 productos de "Células madre y Derivados"

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  • STAT3-IN-36
    Targetmol
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    STAT3-IN-36

    CAS:
    <p>STAT3-IN-36 (compound 11g) is a tritarget inhibitor that selectively targets LRPPRC, STAT3, and CDK1, exhibiting potent anticancer activity. This compound binds to LRPPRC, STAT3, and CDK1, demonstrating more effective anticancer effects than those of TMF or Capecitabine. Additionally, STAT3-IN-36 exhibits an IC50 value of 1.8 μM in HGC27 cells.</p>
    Fórmula:C30H24F2N2O9S2
    Forma y color:Solid
    Peso molecular:658.65

    Ref: TM-T201706

  • dCK1α-2
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    dCK1α-2

    <p>dCK1α-2 is an orally effective CK1α molecular glue (Molecular Glue) degrader that targets p53 pathway-related targets. It demonstrates antitumor efficacy in mouse models by enhancing the expression of p53-related genes.</p>
    Fórmula:C24H24ClN5O4
    Forma y color:Solid
    Peso molecular:481.93

    Ref: TM-T201857

  • JAK3-IN-11
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    JAK3-IN-11

    CAS:
    <p>JAK3-IN-11: potent oral JAK3 inhibitor (IC50=1.7 nM), noncytotoxic, &gt;588-fold selectivity, blocks T-cell growth; useful in autoimmune research.</p>
    Fórmula:C23H23N5O2
    Forma y color:Solid
    Peso molecular:401.46

    Ref: TM-T9811

  • TEAD-IN-10
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    TEAD-IN-10

    CAS:
    <p>TEAD-IN-10 (compound 15), a covalent inhibitor, exhibits selective and potent inhibitory activity against TEAD1 (IC 50 =14 nM), TEAD2 (IC 50 =179 nM), and TEAD3 (IC 50 =4 nM). This compound is utilized in cancer research [1].</p>
    Fórmula:C15H14F3NO
    Forma y color:Solid
    Peso molecular:281.27

    Ref: TM-T87500

  • YAP/TAZ inhibitor-3
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    YAP/TAZ inhibitor-3

    CAS:
    <p>YAP/TAZ inhibitor-3 (Compound 24) is a YAP/TAZ inhibitor applicable for relevant research within the life sciences field.</p>
    Fórmula:C21H18F3NO3
    Pureza:99.63%
    Forma y color:Solid
    Peso molecular:389.37

    Ref: TM-T87651

  • JAK3-IN-7
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    JAK3-IN-7

    CAS:
    <p>JAK3-IN-7 is a potent and selective JAK3 inhibitor (IC50&lt;0.01 μM) for the treatment of rejection in organ transplantation, graft-versus-host reaction after</p>
    Fórmula:C17H20N6O
    Pureza:98.81%
    Forma y color:Solid
    Peso molecular:324.38

    Ref: TM-T10009

  • JAK1/TYK2-IN-4
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    JAK1/TYK2-IN-4

    CAS:
    <p>JAK1/TYK2-IN-4 serves as a dual inhibitor targeting both JAK and TYK2, displaying IC50 values of 39 nM and 21 nM, respectively. It is also orally bioavailable [1].</p>
    Fórmula:C17H23N7O
    Forma y color:Solid
    Peso molecular:341.41

    Ref: TM-T86755

  • (Rac)-SAG
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    (Rac)-SAG

    CAS:
    <p>(Rac)-SAG, an isoform of SAG, is a potent Smoothened (Smo) receptor agonist (EC₅₀ = 3 nM; Kd = 59 nM) that activates the Hedgehog signaling pathway and counteracts Cyclopamine's inhibition of Smo [1] [2] [3].</p>
    Fórmula:C28H28ClN3OS
    Forma y color:Solid
    Peso molecular:490.06

    Ref: TM-T85362

  • Tyk2-IN-14
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    Tyk2-IN-14

    CAS:
    <p>Tyk2-IN-14, a small molecule inhibitor of TYK2, is significant in treating inflammatory diseases and conditions linked to hypersecretion of IFNa and interferons [1].</p>
    Fórmula:C22H21N9O2
    Forma y color:Solid
    Peso molecular:443.46

    Ref: TM-T87583

  • Tyk2-IN-17
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    Tyk2-IN-17

    CAS:
    <p>Tyk2-IN-17 (compound 185) effectively inhibits TYK2 [1].</p>
    Fórmula:C20H20F2N8O
    Forma y color:Solid
    Peso molecular:426.42

    Ref: TM-T87586

  • YLIU-4-105-1
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    YLIU-4-105-1

    CAS:
    <p>YLIU-4-105-1 is a type II JAK2 inhibitor. Demonstrating in vivo pharmacological activity, YLIU-4-105-1 reduces splenic weight, decreases blood reticulocyte counts in a dose-dependent manner, and inhibits pSTAT5.</p>
    Fórmula:C32H34F3N7O2
    Forma y color:Solid
    Peso molecular:605.65

    Ref: TM-T201176

  • Cenacitinib
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    Cenacitinib

    CAS:
    <p>Cenacitinib is an effective inhibitor of Janus kinase (Janus kinase) and possesses anti-inflammatory activity.</p>
    Fórmula:C19H19F2N7O3
    Forma y color:Solid
    Peso molecular:431.40

    Ref: TM-T201149

  • Tyk2-IN-20
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    Tyk2-IN-20

    CAS:
    <p>Tyk2-IN-20 (Example 289) is an effective inhibitor of Tyk2 with an IC50 value below 5 nM. Additionally, it inhibits JAK1, JAK2, and JAK3 with IC50 values under 100 nM. This compound is utilized for the research of inflammatory diseases.</p>
    Fórmula:C24H25N7O2
    Forma y color:Solid
    Peso molecular:443.50

    Ref: TM-T201155

  • WZ-2-033
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    WZ-2-033

    CAS:
    <p>WZ-2-033 is a potent STAT3 inhibitor. It inhibits proliferation, colony survival, migration, and invasion of MDA-MB-231, HCC70, and MDA-MB231-4175 cells, with IC50 values of 0.7, 1.3, and 1.3 μM respectively.</p>
    Fórmula:C25H18F3N3O4S
    Forma y color:Solid
    Peso molecular:513.49

    Ref: TM-T200925

  • Casein kinase 1δ-IN-13
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    Casein kinase 1δ-IN-13

    CAS:
    Casein kinase1δ-IN-13 (compound 401) is an inhibitor of Casein kinase1δ. It is utilized in the research of neurodegenerative diseases.
    Fórmula:C15H13N3O2S
    Forma y color:Solid
    Peso molecular:299.35

    Ref: TM-T201094

  • GDC-9918
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    GDC-9918

    CAS:
    <p>GDC-9918 (compound GDC-9918) is an inhibitor of Janus kinases.</p>
    Fórmula:C20H18F2N6O5S
    Forma y color:Solid
    Peso molecular:492.46

    Ref: TM-T201178

  • Tyk2-IN-15
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    Tyk2-IN-15

    CAS:
    <p>Tyk2-IN-15 (Compound 97) is a selective inhibitor of tyrosine kinase 2 (Tyk2) with an IC50 value ≤ 10 nM for Tyk2-JH2. It is utilized in the research of inflammatory and autoimmune diseases [1].</p>
    Fórmula:C21H25F2N7O
    Forma y color:Solid
    Peso molecular:429.47

    Ref: TM-T87584

  • CDK8-IN-11
    Targetmol
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    CDK8-IN-11

    CAS:
    <p>CDK8-IN-11 is a CDK8 inhibitor that demonstrates anti-proliferative activity against colon cancer cell lines and inhibits the activation of WNT/β-catenin.</p>
    Fórmula:C19H15F3N4O2
    Pureza:99.74%
    Forma y color:Solid
    Peso molecular:388.34

    Ref: TM-T61742

  • JAK3 covalent inhibitor-1
    Targetmol
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    JAK3 covalent inhibitor-1

    CAS:
    <p>JAK3 Covalent Inhibitor-1 is a compound characterized by its potent and selective inhibition of Janus kinase 3 (JAK3), possessing an IC50 of 11 nM and</p>
    Fórmula:C22H17FN6O2S
    Pureza:98%
    Forma y color:Solid
    Peso molecular:448.47

    Ref: TM-T11709

  • Londamocitinib
    Targetmol
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    Londamocitinib

    CAS:
    <p>Londamocitinib (JAK1-IN-7) is a selective and potent JAK1 inhibitor with anti-inflammatory activity.</p>
    Fórmula:C28H31F2N7O4S
    Pureza:98.64% - 99.56%
    Forma y color:Solid
    Peso molecular:599.65

    Ref: TM-T11706