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Células madre y Derivados

Células madre y Derivados

Los inhibidores de células madre son compuestos que se dirigen específicamente a las vías de señalización y proteínas involucradas en el mantenimiento, diferenciación y proliferación de células madre. Estos inhibidores son cruciales para comprender la biología de las células madre y para desarrollar estrategias que permitan manipularlas con fines terapéuticos, como en la medicina regenerativa y el tratamiento del cáncer. Al controlar el destino de las células madre, estos inhibidores pueden ayudar a guiar la diferenciación de células madre en tipos celulares específicos o prevenir el crecimiento celular no deseado. En CymitQuimica, ofrecemos una selección de inhibidores de células madre de alta calidad para apoyar su investigación en biología de células madre, biología del desarrollo y medicina regenerativa.

Subcategorías de "Células madre y Derivados"

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Se han encontrado 694 productos de "Células madre y Derivados"

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  • H-1152 dihydrochloride
    Targetmol
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    H-1152 dihydrochloride

    CAS:
    <p>H-1152 2HCl: ROCK inhibitor, IC50=12 nM, Ki=1.6 nM. Blocks PKA, PKC, PKG, Aurora A, CaMKII with higher IC50s.</p>
    Fórmula:C16H23Cl2N3O2S
    Pureza:99.85%
    Forma y color:Solid
    Peso molecular:392.34

    Ref: TM-T35328

  • STAT6-IN-2
    Targetmol
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    STAT6-IN-2

    CAS:
    <p>STAT6-IN-2(R)-84 is a STAT6 inhibitor that inhibits the secretion of eotaxin-3 and the tyrosine phosphorylation of STAT6.</p>
    Fórmula:C28H31N5O2
    Pureza:99.67%
    Forma y color:Solid
    Peso molecular:469.58

    Ref: TM-T79185

  • GSK-3 inhibitor 1
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    GSK-3 inhibitor 1

    CAS:
    <p>GSK-3 inhibitor 1 is a GSK-3 inhibitor.</p>
    Fórmula:C22H17ClFN5O2
    Pureza:98.42%
    Forma y color:Solid
    Peso molecular:437.85

    Ref: TM-T11468

  • LNK01004
    Targetmol
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    LNK01004

    CAS:
    <p>LNK01004 is a JAK inhibitor that exhibits potent inhibitory effects on JAK1 (IC50: 10 nM), JAK2 (IC50: ＜0.51 nM), and TYK2 (IC50: 1.0 nM). It can concurrently inhibit multiple cytokine-induced p-STAT signaling pathways and is applicable for research on diseases such as atopic dermatitis.</p>
    Fórmula:C26H31N7O2
    Forma y color:Solid
    Peso molecular:473.57

    Ref: TM-T205387

  • Milpecitinib
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    Milpecitinib

    CAS:
    <p>Milpecitinib (Compound 21a) is a potent and selective Janus tyrosine kinase (JAK) inhibitor with anti-inflammatory properties. It shows promise for research in cancer and inflammatory diseases.</p>
    Fórmula:C20H20N4O2S
    Forma y color:Solid
    Peso molecular:380.463

    Ref: TM-T205326

  • TYK2 ligand 2
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    TYK2 ligand 2

    CAS:
    <p>TYK2ligand 2 is the TYK2 ligand of PROTACTYD-68. TYD-68 is a highly potent and selective CRBN-recruiting TYK2 PROTAC degrader with a DC50 value of 0.42 nM.</p>
    Fórmula:C24H20FN7O4
    Forma y color:Solid
    Peso molecular:489.458

    Ref: TM-T206678

  • TEAD-IN-20
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    TEAD-IN-20

    CAS:
    <p>TEAD-IN-20 is a TEAD inhibitor with IC50 values of 0.021 μM in TEAD4 FRET and 0.044 μM in TEAD4 MCF7-Tead cell lines. It has potential applications in cancer research.</p>
    Fórmula:C20H19F3N4O3
    Forma y color:Solid
    Peso molecular:420.39

    Ref: TM-T207373

  • Logo de CymitQuimica
    Targetmol
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    JAK-IN-19

    <p>JAK-IN-19 inhibits JAK (pIC50: 7.2, 7.7), less so for VEGFR2 (7.0) and Aurora B (5.8).</p>
    Fórmula:C26H36FN5O2
    Forma y color:Solid
    Peso molecular:469.59

    Ref: TM-T63026

  • M3686
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    M3686

    CAS:
    <p>M3686 (Compound 29) is a potent and selective TEAD1 inhibitor with an IC50 value of 51 nM. It exhibits weaker binding activity toward TEAD3. M3686 significantly inhibits the cellular activity of YAP-dependent NCI-H226 cell lines, with an IC50 value of 0.06 μM, and demonstrates strong antitumor effects in the NCI-H226 xenograft model.</p>
    Fórmula:C21H18F3N5O2
    Forma y color:Solid
    Peso molecular:429.395

    Ref: TM-T205477

  • lirucitinib
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    lirucitinib

    CAS:
    <p>Lirucitinib is a JAK inhibitor known for its anti-inflammatory properties.</p>
    Fórmula:C16H25N5OS
    Forma y color:Solid
    Peso molecular:335.468

    Ref: TM-T205259

  • iBFAR2
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    iBFAR2

    CAS:
    <p>iBFAR2, an inhibitor of BFAR, restores the CD8+ tumor-resident memory T cell subset against solid tumors. It promotes the binding of JAK2-STAT1 and enhances the phosphorylation of STAT1.</p>
    Fórmula:C19H15F3N2O2
    Forma y color:Solid
    Peso molecular:360.33

    Ref: TM-T204531

  • CEE321
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    CEE321

    CAS:
    <p>CEE321 is an effective pan-JAK inhibitor with an IC50 of 54 nM. It effectively inhibits biomarkers associated with atopic dermatitis.</p>
    Fórmula:C18H16ClN5O
    Forma y color:Solid
    Peso molecular:353.806

    Ref: TM-T204824

  • TEAD-IN-1
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    TEAD-IN-1

    CAS:
    <p>TEAD-IN-1 (Compound 2) is an effective inhibitor of TEAD auto-palmitoylation with an IC50 of 603 nM. It enhances the interaction between TEAD and VGLL4, while diminishing the interaction between YAP and TEAD. TEAD-IN-1 is applicable for cancer research.</p>
    Fórmula:C15H20F2N2O3S
    Forma y color:Solid
    Peso molecular:346.393

    Ref: TM-T204883

  • TGFβ1-IN-1
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    TGFβ1-IN-1

    CAS:
    <p>TGFβ1-IN-1 is a TGF-β1 inhibitor that inhibits the production of TGF-β1-induced fibrosis markers (α-SMA and fibronectin) and can be used in cancer research.</p>
    Fórmula:C22H24N2O3
    Pureza:99.89% - 99.89%
    Forma y color:Solid
    Peso molecular:364.438

    Ref: TM-T61389

  • JAK1-IN-16
    Targetmol
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    JAK1-IN-16

    <p>JAK1-IN-16 (compound 4l) acts as an inhibitor of JAK1/STAT3 and effectively downregulates the expression of TLR4 protein.</p>
    Fórmula:C20H15ClF3N3OS
    Forma y color:Solid
    Peso molecular:437.87

    Ref: TM-T201648

  • STAT3-IN-8
    Targetmol
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    STAT3-IN-8

    CAS:
    <p>"STAT3-IN-8 (compound H172) is a potent inhibitor of STAT3 with potential applications in cancer research [1]."</p>
    Fórmula:C19H7F7N2O3
    Pureza:98%
    Forma y color:Solid
    Peso molecular:444.26

    Ref: TM-T71550

  • ROCK/HDAC-IN-1
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    ROCK/HDAC-IN-1

    <p>ROCK/HDAC-IN-1 (Compound 10h) serves as an orally effective inhibitor of ROCK/HDAC. This compound suppresses ROCK1/2 (IC50: 254.9 nM, 58.18 nM) and HDAC1/2/3/6/8 (IC50: 9.09, 8.03, 6.26, 0.41, 7.69 nM). It stimulates the activation of DAMPs, notably calreticulin (CRT) exposure and HMGB1 release, suggesting its potential as an inducer of immunogenic cell death (ICD). ROCK/HDAC-IN-1 exhibits antiproliferative effects against breast cancer cells (IC50: 0.37 μM for MDA-MB-231 cells), inhibits tumor growth, activates T cells, and shows no significant toxicity.</p>
    Fórmula:C19H22N4O3S
    Forma y color:Solid
    Peso molecular:386.47

    Ref: TM-T201708

  • MGD-28
    Targetmol
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    MGD-28

    CAS:
    <p>MGD-28 is a Cullin-CRBN-dependent IKZF family protein degrader for IKZF1 (Ikaros), IKZF2 (Helios), IKZF3 (Aiolos) ,and CK1α, antiproliferative.</p>
    Fórmula:C33H34FN7O3
    Pureza:99.39%
    Forma y color:Solid
    Peso molecular:595.67

    Ref: TM-T201415

  • (R)-9b
    Targetmol
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    (R)-9b

    CAS:
    <p>(R)-9b is an effective inhibitor of the ACK1 tyrosine kinase (IC50=56 nM) and exhibits anticancer activity. It selectively targets ACK1 but also inhibits kinases in the JAK family, specifically JAK2 and Tyk2. (R)-9b is used in research related to hormone-regulated cancers, such as prostate cancer and breast cancer.</p>
    Fórmula:C20H27ClN6O
    Forma y color:Solid
    Peso molecular:402.92

    Ref: TM-T201776

  • (+)-ITD-1
    Targetmol
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    (+)-ITD-1

    CAS:
    <p>(+)-ITD-1 is an inhibitor of TGF-β, effectively inhibiting TGF-β2 with an IC50 of 0.46 μM. It promotes the degradation of the TGF-β type II receptor (TGFBR2) and the differentiation of cardiomyocytes. Additionally, it suppresses the formation of the mesoderm during the early differentiation of mouse embryonic stem cells (mESCs).</p>
    Fórmula:C27H29NO3
    Forma y color:Solid
    Peso molecular:415.52

    Ref: TM-T201672