Receptor del factor de crecimiento de fibroblastos (FGFR)
Los inhibidores de FGFR (receptores del factor de crecimiento de fibroblastos) son terapias dirigidas que bloquean la actividad de los FGFR, los cuales están involucrados en la proliferación celular, diferenciación y angiogénesis. La señalización de FGFR contribuye a la formación de nuevos vasos sanguíneos en los tumores, promoviendo su crecimiento y supervivencia. Inhibir FGFR puede, por lo tanto, reducir la angiogénesis y la progresión tumoral. En CymitQuimica, ofrecemos una gama de inhibidores de FGFR de alta calidad para apoyar su investigación en cáncer, biología del desarrollo y angiogénesis.
Se han encontrado 177 productos de "Receptor del factor de crecimiento de fibroblastos (FGFR)"
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FGFR-IN-6
CAS:FGFR-IN-6 (Compound 5) is an FGFR inhibitor.Fórmula:C23H22N6O3Forma y color:SolidPeso molecular:430.46AZ8010
CAS:AZ8010 (AZ12908010) serves as an effective inhibitor of FGFR1-3 and exhibits antiproliferative properties, making it useful for cancer research.Fórmula:C27H34N4O3Forma y color:SolidPeso molecular:462.58FGFR4-IN-4
CAS:FGFR4-IN-4 is a FGFR4 inhibitor with anti-tumor activity.Fórmula:C28H32Cl2N6O5Pureza:98%Forma y color:SolidPeso molecular:603.5PNU-145156E
CAS:PNU-145156E is a noncytotoxic molecule inhibiting growth and angiogenic factors, suppress tumor angiogenesis, support anti-angiogenic research strategies.Fórmula:C45H40N10O17S4Forma y color:SolidPeso molecular:1121.12FGFR-IN-15
FGFR-IN-15 (compound 18i) acts as a pan-FGFR inhibitor, exhibiting potent inhibitory activity against FGFR1-4.Fórmula:C22H23N5O5SForma y color:SolidPeso molecular:469.51FGFR-IN-16
CAS:FGFR-IN-16 (compound 7N) is a potent inhibitor of FGFR1, FGFR2, and FGFR4, exhibiting IC50 values of 8 nM, 4 nM, and 3.8 nM respectively. It plays a crucial role in cancer research.Fórmula:C30H27Cl2N7O4Forma y color:SolidPeso molecular:620.49FGFR3-IN-4
CAS:FGFR3-IN-4 is a selective inhibitor targeting FGFR3, demonstrating an IC50 value of under 50 nM.Fórmula:C26H24ClN7OForma y color:SolidPeso molecular:485.97FGFR4-IN-9
FGFR4-IN-9 is a selective inhibitor of FGFR4 (IC50: 75.3 nM) that effectively inhibits the growth and angiogenesis of hepatocellular carcinoma cells.Fórmula:C24H22ClF3N4O4Forma y color:SolidPeso molecular:522.9FGFR-IN-5
CAS:FGFR-IN-5 is a potent inhibitor of FGFR. FGFR-IN-5 has potential for research in cancer diseases.Fórmula:C25H22N6O3Forma y color:SolidPeso molecular:454.48FGFR4-IN-6
FGFR4-IN-6: covalent, reversible FGFR4 blocker, 5.4 nM IC50, good oral bioavailability, reduces Hep3B2.1-7 tumors in mice, low toxicity.Fórmula:C31H33N7O4Forma y color:SolidPeso molecular:567.64E7090 succinate
CAS:E7090 succinate inhibits FGFR1, FGFR2, and FGFR3 with IC50: 0.71, 0.50, 1.2 nM; less so FGFR4 at 120 nM.Fórmula:C76H92N10O24Forma y color:SolidPeso molecular:1529.60FGFR1 inhibitor-6
FGFR1 inhibitor-6, IC50: 16.31 nM, blocks cell cycle at pro-G1/G2/M and induces apoptosis.Fórmula:C27H19N5O4S2Forma y color:SolidPeso molecular:541.6CEP-11981
CAS:CEP-11981 is an orally active TIE2/pan-VEGFR inhibitor with broad tyrosine kinase inhibitory activity, antitumour and anti-angiogenic, refractory solid tumours.Fórmula:C28H27N7OPureza:99.58%Forma y color:SolidPeso molecular:477.56FGFR4-IN-10
FGFR4-IN-10 (compound 5a) is a potent, selective FGFR4 inhibitor with IC50 of 70.7 nM, sparing FGFR1-3.Fórmula:C20H19F3N6O3Forma y color:SolidPeso molecular:448.4FGFR1 inhibitor-17
CAS:FGFR1inhibitor-17 (Compound 92) is a potent inhibitor of FGFR1, with promising applications in cancer research.Fórmula:C16H13ClN2O3Forma y color:SolidPeso molecular:316.739FGFR1 inhibitor-16
CAS:FGFR1inhibitor-16 (Compound 89) functions as an FGFR1 inhibitor, demonstrating an inhibition rate of 53.00% at a concentration of 50 μM and 24.95% at 10 μM. It is utilized in tumor research.Fórmula:C16H9N5O3SForma y color:SolidPeso molecular:351.339FGFR1 inhibitor-10
CAS:FGFR1 inhibitor-10 (Compound 4i), with an IC50 of 28 nM, effectively inhibits FGFR1 phosphorylation.
Fórmula:C26H30F3N7O2SPureza:98%Forma y color:SolidPeso molecular:561.62Ref: TM-T79686
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