Receptor del factor de crecimiento de fibroblastos (FGFR)
Los inhibidores de FGFR (receptores del factor de crecimiento de fibroblastos) son terapias dirigidas que bloquean la actividad de los FGFR, los cuales están involucrados en la proliferación celular, diferenciación y angiogénesis. La señalización de FGFR contribuye a la formación de nuevos vasos sanguíneos en los tumores, promoviendo su crecimiento y supervivencia. Inhibir FGFR puede, por lo tanto, reducir la angiogénesis y la progresión tumoral. En CymitQuimica, ofrecemos una gama de inhibidores de FGFR de alta calidad para apoyar su investigación en cáncer, biología del desarrollo y angiogénesis.
Se han encontrado 170 productos de "Receptor del factor de crecimiento de fibroblastos (FGFR)"
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Infigratinib-Boc
CAS:<p>Infigratinib-Boc, a derivative of the ATP-competitive pan-FGFR inhibitor Infigratinib, incorporates a Boc (t-Butyloxy carbonyl) group [1].</p>Fórmula:C29H35Cl2N7O5Forma y color:SolidPeso molecular:632.54FGFR4-IN-8
CAS:<p>FGFR4-IN-8 is a selective, ATP-competitive FGFR4 inhibitor with IC50s as low as 0.25 nM, halting growth of Hep3B cells at 29 nM and showing in vivo efficacy.</p>Fórmula:C32H34Cl2FN7O3Pureza:98%Forma y color:SolidPeso molecular:654.56FGFR-IN-11
CAS:<p>FGFR-IN-11 (compound I-5) is an orally active, covalent inhibitor of FGFR, exhibiting IC50 values of 9.9 nM (FGFR1), 3.1 nM (FGFR2), 16 nM (FGFR3), and 1.8 nM (</p>Fórmula:C28H29ClN4O4Pureza:98%Forma y color:SolidPeso molecular:521.01Resigratinib
CAS:<p>Resigratinib (KIN-3248) is an oral, irreversible pan-FGFR family protein inhibitor, covalently binds to and inhibits all four FGFR isoforms(FGFR1/2/3/4).</p>Fórmula:C26H27F2N7O3Pureza:98.58%Forma y color:SolidPeso molecular:523.53FGFR3-IN-6
CAS:<p>FGFR3-IN-6 is a potent, selective inhibitor of FGFR 3, exhibiting an IC50 value of less than 350 nM , and is utilized in cancer research [1].</p>Fórmula:C25H23FN8O2Pureza:98%Forma y color:SolidPeso molecular:486.5FGFR3-IN-7
CAS:<p>FGFR3-IN-7 is a potent, selective inhibitor of FGFR 3, demonstrating an IC50 value of less than 350 nM , and is utilized in cancer research [1].</p>Fórmula:C25H24FN9OPureza:98%Forma y color:SolidPeso molecular:485.52FGFR4-IN-16
CAS:<p>FGFR4-IN-16 (CY-15-2) is a covalent inhibitor targeting FGFR-4, utilized in cancer research [1].</p>Fórmula:C35H30Cl2N6O5Pureza:98%Forma y color:SolidPeso molecular:685.56Irpagratinib
CAS:<p>Irpagratinib (ABSK011) is an FGFR4 antagonist with anticancer activity, inhibiting FGFR4 autophosphorylation and blocking downstream signaling pathways.</p>Fórmula:C28H32F2N6O5Pureza:99.08% - 99.38%Forma y color:SolidPeso molecular:570.59FIIN-1
CAS:<p>FIIN-1 (FGFR irreversible inhibitor-1) is an irreversible and selective FGFR inhibitor with Kd of 2.8, 6.9, 5.4, 120, 32 and 120 nM for FGFR1, FGFR2, FGFR3,</p>Fórmula:C32H39Cl2N7O4Pureza:98.75%Forma y color:SolidPeso molecular:656.6FGFR3-IN-4
CAS:<p>FGFR3-IN-4 is a selective inhibitor targeting FGFR3, demonstrating an IC50 value of under 50 nM.</p>Fórmula:C26H24ClN7OForma y color:SolidPeso molecular:485.97FGFR4-IN-9
<p>FGFR4-IN-9 is a selective inhibitor of FGFR4 (IC50: 75.3 nM) that effectively inhibits the growth and angiogenesis of hepatocellular carcinoma cells.</p>Fórmula:C24H22ClF3N4O4Forma y color:SolidPeso molecular:522.9FGFR-IN-5
CAS:<p>FGFR-IN-5 is a potent inhibitor of FGFR. FGFR-IN-5 has potential for research in cancer diseases.</p>Fórmula:C25H22N6O3Forma y color:SolidPeso molecular:454.48FGFR-IN-6
CAS:<p>FGFR-IN-6 (Compound 5) is an FGFR inhibitor.</p>Fórmula:C23H22N6O3Forma y color:SolidPeso molecular:430.46FGFR4-IN-6
<p>FGFR4-IN-6: covalent, reversible FGFR4 blocker, 5.4 nM IC50, good oral bioavailability, reduces Hep3B2.1-7 tumors in mice, low toxicity.</p>Fórmula:C31H33N7O4Forma y color:SolidPeso molecular:567.64E7090 succinate
CAS:<p>E7090 succinate inhibits FGFR1, FGFR2, and FGFR3 with IC50: 0.71, 0.50, 1.2 nM; less so FGFR4 at 120 nM.</p>Fórmula:C76H92N10O24Forma y color:SolidPeso molecular:1529.60FGFR1 inhibitor-6
<p>FGFR1 inhibitor-6, IC50: 16.31 nM, blocks cell cycle at pro-G1/G2/M and induces apoptosis.</p>Fórmula:C27H19N5O4S2Forma y color:SolidPeso molecular:541.6CEP-11981
CAS:<p>CEP-11981 is an orally active TIE2/pan-VEGFR inhibitor with broad tyrosine kinase inhibitory activity, antitumour and anti-angiogenic, refractory solid tumours.</p>Fórmula:C28H27N7OPureza:99.58%Forma y color:SolidPeso molecular:477.56FGFR4-IN-10
<p>FGFR4-IN-10 (compound 5a) is a potent, selective FGFR4 inhibitor with IC50 of 70.7 nM, sparing FGFR1-3.</p>Fórmula:C20H19F3N6O3Forma y color:SolidPeso molecular:448.4AZ8010
CAS:<p>AZ8010 (AZ12908010) serves as an effective inhibitor of FGFR1-3 and exhibits antiproliferative properties, making it useful for cancer research.</p>Fórmula:C27H34N4O3Forma y color:SolidPeso molecular:462.58FGFR1 inhibitor-17
CAS:<p>FGFR1inhibitor-17 (Compound 92) is a potent inhibitor of FGFR1, with promising applications in cancer research.</p>Fórmula:C16H13ClN2O3Forma y color:SolidPeso molecular:316.739
