Receptor del factor de crecimiento de fibroblastos (FGFR)
Los inhibidores de FGFR (receptores del factor de crecimiento de fibroblastos) son terapias dirigidas que bloquean la actividad de los FGFR, los cuales están involucrados en la proliferación celular, diferenciación y angiogénesis. La señalización de FGFR contribuye a la formación de nuevos vasos sanguíneos en los tumores, promoviendo su crecimiento y supervivencia. Inhibir FGFR puede, por lo tanto, reducir la angiogénesis y la progresión tumoral. En CymitQuimica, ofrecemos una gama de inhibidores de FGFR de alta calidad para apoyar su investigación en cáncer, biología del desarrollo y angiogénesis.
Se han encontrado 180 productos de "Receptor del factor de crecimiento de fibroblastos (FGFR)"
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Tec-IN-6
CAS:Tec-IN-6 is an inhibitor of Tec kinase, it also blocks unconventional secretion of fibroblast growth factor 2 (FGF2).Fórmula:C19H19N3O5Pureza:98%Forma y color:SolidPeso molecular:369.37CPL304110
CAS:CPL304110: oral, selective FGFR 1-3 inhibitor; IC50 - FGFR1: 0.75nM, FGFR2: 0.5nM, FGFR3: 3.05nM.Fórmula:C25H30N6O2Forma y color:SolidPeso molecular:446.54PP58
CAS:PP58 is an inhibitor of PDGFR, FGFR and Src family.Fórmula:C22H19Cl2N5O2Pureza:99.21%Forma y color:SolidPeso molecular:456.32Resigratinib
CAS:Resigratinib (KIN-3248) is an oral, irreversible pan-FGFR family protein inhibitor, covalently binds to and inhibits all four FGFR isoforms(FGFR1/2/3/4).Fórmula:C26H27F2N7O3Pureza:98.58%Forma y color:SolidPeso molecular:523.53FGFR3-IN-6
CAS:FGFR3-IN-6 is a potent, selective inhibitor of FGFR 3, exhibiting an IC50 value of less than 350 nM , and is utilized in cancer research [1].Fórmula:C25H23FN8O2Pureza:98%Forma y color:SolidPeso molecular:486.5SNIPER(TACC3)-11
CAS:SNIPER(TACC3)-11 is a powerful FGFR3-TACC3 protein degrader, reducing its amount and hindering FGFR3-TACC3+ cancer cell growth.Fórmula:C51H66N10O7S2Forma y color:SolidPeso molecular:995.26FGFR-IN-4
CAS:FGFR-IN-4 is a potent inhibitor of FGFR. FGFR-IN-4 has potential for cancer disease studies.Fórmula:C24H21N7O2Forma y color:SolidPeso molecular:439.47FGFR4-IN-16
CAS:FGFR4-IN-16 (CY-15-2) is a covalent inhibitor targeting FGFR-4, utilized in cancer research [1].Fórmula:C35H30Cl2N6O5Pureza:98%Forma y color:SolidPeso molecular:685.56FGFR-IN-2
CAS:FGFR-IN-2 (compound 1) is a potent inhibitor of FGFR, acting on FGFR1 (IC50: 7.3 nM), FGFR2 (IC50: 4.3 nM), FGFR3 (IC50: 7.6 nM) and FGFR4 (IC50: 11 nM).Fórmula:C25H30N6O2Forma y color:SolidPeso molecular:446.54TG 100572 Hydrochloride
CAS:TG 100572 Hydrochloride is a inhibitor of multi-targeted kinase which inhibits receptor tyrosine kinases and Src kinases(IC50s of 2, 7, 2, 16, 13, 5, 0.5, 6, 0.Fórmula:C26H27Cl2N5O2Pureza:98%Forma y color:SolidPeso molecular:512.43Irpagratinib
CAS:Irpagratinib (ABSK011) is an FGFR4 antagonist with anticancer activity, inhibiting FGFR4 autophosphorylation and blocking downstream signaling pathways.Fórmula:C28H32F2N6O5Pureza:99.08% - 99.38%Forma y color:SolidPeso molecular:570.59CP-547632 TFA
CAS:CP-547632 TFA, an oral VEGFR-2 and FGF inhibitor, IC50: VEGFR-2 at 11 nM, FGF at 9 nM, shows antitumor activity.Fórmula:C22H25BrF5N5O5SPureza:98%Forma y color:SolidPeso molecular:646.43TYRA-300
CAS:TYRA-300 is an oral and selective FGFR3 inhibito, in the Ba/F3 cell line for the treatment of metastatic uroepithelial carcinomas (mUCs) and chondrodysplasia.Fórmula:C25H24Cl2N6O3SPureza:99.66%Forma y color:SolidPeso molecular:559.47Ref: TM-T88841
1mg382,00€5mg696,00€10mg947,00€25mg1.554,00€50mg2.034,00€100mg2.749,00€1mL*10mM (DMSO)856,00€Sulfatinib
CAS:Sulfatinib (KDR-IN-1) (HMPL-012) is a potent and highly selective tyrosine kinase inhibitor against VEGFR1/2/3, FGFR1 and CSF1R with IC 50 s ranging from 1 toFórmula:C24H28N6O3SPureza:99.21% - >99.99%Forma y color:SolidPeso molecular:480.58FGFR3-IN-7
CAS:FGFR3-IN-7 is a potent, selective inhibitor of FGFR 3, demonstrating an IC50 value of less than 350 nM , and is utilized in cancer research [1].Fórmula:C25H24FN9OPureza:98%Forma y color:SolidPeso molecular:485.52FGFR-IN-11
CAS:FGFR-IN-11 (compound I-5) is an orally active, covalent inhibitor of FGFR, exhibiting IC50 values of 9.9 nM (FGFR1), 3.1 nM (FGFR2), 16 nM (FGFR3), and 1.8 nM (Fórmula:C28H29ClN4O4Pureza:98%Forma y color:SolidPeso molecular:521.01Infigratinib-Boc
CAS:Infigratinib-Boc, a derivative of the ATP-competitive pan-FGFR inhibitor Infigratinib, incorporates a Boc (t-Butyloxy carbonyl) group [1].Fórmula:C29H35Cl2N7O5Forma y color:SolidPeso molecular:632.54FGFR4-IN-8
CAS:FGFR4-IN-8 is a selective, ATP-competitive FGFR4 inhibitor with IC50s as low as 0.25 nM, halting growth of Hep3B cells at 29 nM and showing in vivo efficacy.Fórmula:C32H34Cl2FN7O3Pureza:98%Forma y color:SolidPeso molecular:654.56FIIN-1
CAS:FIIN-1 (FGFR irreversible inhibitor-1) is an irreversible and selective FGFR inhibitor with Kd of 2.8, 6.9, 5.4, 120, 32 and 120 nM for FGFR1, FGFR2, FGFR3,Fórmula:C32H39Cl2N7O4Pureza:98.75%Forma y color:SolidPeso molecular:656.6Ref: TM-T37426
1mg74,00€2mg98,00€5mg192,00€10mg313,00€25mg520,00€50mg742,00€100mg982,00€500mg2.008,00€FGFR4-IN-4
CAS:FGFR4-IN-4 is a FGFR4 inhibitor with anti-tumor activity.Fórmula:C28H32Cl2N6O5Pureza:98%Forma y color:SolidPeso molecular:603.5
