Receptor del factor de crecimiento de fibroblastos (FGFR)
Los inhibidores de FGFR (receptores del factor de crecimiento de fibroblastos) son terapias dirigidas que bloquean la actividad de los FGFR, los cuales están involucrados en la proliferación celular, diferenciación y angiogénesis. La señalización de FGFR contribuye a la formación de nuevos vasos sanguíneos en los tumores, promoviendo su crecimiento y supervivencia. Inhibir FGFR puede, por lo tanto, reducir la angiogénesis y la progresión tumoral. En CymitQuimica, ofrecemos una gama de inhibidores de FGFR de alta calidad para apoyar su investigación en cáncer, biología del desarrollo y angiogénesis.
Se han encontrado 180 productos de "Receptor del factor de crecimiento de fibroblastos (FGFR)"
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MAX-40279 hemifumarate
CAS:MAX-40279 hemifumarate inhibits FLT3 and FGFR kinases, showing promise for AML treatment.Fórmula:C48H50F2N12O6S2Forma y color:SolidPeso molecular:993.12ARQ 069
CAS:ARQ 069 inhibits FGFR2 phosphorylation concentration-dependently (IC50: 9.7 µM), without affecting β-actin. Preferentially binds inactive FGFR1/2.Fórmula:C18H15N3Pureza:98%Forma y color:SolidPeso molecular:273.33FGFR3-IN-2
CAS:FGFR3-IN-2 (compound 18b) is a potent and selective FGFR3 inhibitor that inhibits FGFR3 (IC50: 4.1 nM) and VEGFR2 (IC50: 570 nM).Fórmula:C28H39N9O4SForma y color:SolidPeso molecular:597.73Rogaratinib
CAS:Rogaratinib (BAY1163877) is an aberrant inhibitor of fibroblast growth factor receptor (FGFR).Fórmula:C23H26N6O3SPureza:99.54%Forma y color:SolidPeso molecular:466.56SSR128129E free acid
CAS:SSR128129E free acid is an orally available and allosteric inhibitor of FGFR(IC50 of 1.9 μM for FGFR1).Fórmula:C18H16N2O4Pureza:98%Forma y color:SolidPeso molecular:324.33FGFR-IN-9
FGFR-IN-9: oral FGFR inhibitor, IC50: 17.1 nM (FGFR4 WT), 29.6 (FGFR3), 30.7 (V550L), 46.7 (FGFR2), 64.3 nM (FGFR1).Fórmula:C25H28N6O3SForma y color:SolidPeso molecular:492.59FGFR-IN-3
CAS:FGFR-IN-3: potent, oral FGFR modulator, BBB-penetrating, neuroprotective, potential in neurodegeneration study.Fórmula:C18H27F2N5O2Forma y color:SolidPeso molecular:383.44Derazantinib Racemate
CAS:Derazantinib Racemate is an oral ATP competitive kinase inhibitor targeting FGFR1/2/3 (IC50s: 4.5/1.8/4.5 nM).Fórmula:C29H29FN4OPureza:98%Forma y color:SolidPeso molecular:468.57SUN13837
CAS:SUN13837, an oral FGFR modulator, crosses the BBB and shows neuroprotective promise.Fórmula:C21H29N5O2Forma y color:SolidPeso molecular:383.49FGFR3-IN-1
CAS:FGFR3-IN-1 (compound 1) is a fibroblast growth factor receptor (FGFR) inhibitor that inhibits FGFR1 (IC50: 40 nM), FGFR2 (IC50: 5.1 nM) and FGFR3 (IC50: 12 nM).Fórmula:C28H39N9O3SForma y color:SolidPeso molecular:581.73FGFR-IN-7
CAS:FGFR-IN-7: Oral FGFR modulator, crosses blood-brain barrier, neuroprotective, phospholipidosis-resistant, useful for neurodegeneration study.Fórmula:C16H21ClF2N4O2Forma y color:SolidPeso molecular:374.81FIIN-4
CAS:FIIN-4 is a covalent inhibitor of FGFR and can be used in studies about metastatic breast cancer.Fórmula:C35H38N8O4Pureza:99.99%Forma y color:SolidPeso molecular:634.73TG 100801 Hydrochloride
CAS:TG 100801: prodrug for macular degeneration. TG 100572: inhibits kinases (VEGFRs, FGFRs, PDGFRβ, Src family), with varying IC50s.Fórmula:C33H31Cl2N5O3Pureza:98%Forma y color:SolidPeso molecular:616.54FGFR4-IN-11
CAS:FGFR4-IN-11: selective, covalent FGFR4 inhibitor; IC50=2.1 nM; blocks FGF19 pathway; anticancer.Fórmula:C29H29N5O5Forma y color:SolidPeso molecular:527.57Infigratinib phosphate
CAS:Infigratinib phosphate (BGJ-398 phosphate) is an effective inhibitor of the FGFR family (IC50: 0.9 nM, 1.4 nM, 1 nM, and 60 nM for FGFR1, FGFR2, FGFR3, andFórmula:C26H34Cl2N7O7PPureza:99.24% - 99.6%Forma y color:SolidPeso molecular:658.47MAX-40279 hydrochloride
CAS:MAX-40279 HCl: potent FLT3/FGFR inhibitor; potential in AML research.Fórmula:C22H24ClFN6OSForma y color:SolidPeso molecular:474.98FGFR3-IN-5
CAS:FGFR3-IN-5: potent, selective FGFR3 inhibitor. IC50: 3 nM FGFR3, 44 nM FGFR2, 289 nM FGFR1. For cancer research.Fórmula:C24H24FN7O3Forma y color:SolidPeso molecular:477.49CAY10583
CAS:CAY10583 is a selective BLT2 agonist that increases TGF-β1 and bFGF, promotes keratinocyte migration, accelerates wound healing in diabetic mice.Fórmula:C25H25NO3Pureza:>99.99% - >99.99%Forma y color:SolidPeso molecular:387.47TYRA-200
CAS:TYRA-200, Oral FGFR1/2/3 inhibitor, induces tumor regression in wild-type/mutant FGFR2 models, for intrahepatic cholangiocarcinoma.Fórmula:C23H24FN7O2Forma y color:SolidPeso molecular:449.48Atrinositol
CAS:Atrinositol improves energy homeostasis in a mouse model of pancreatic cancer.Fórmula:C6H15O15P3Forma y color:SolidPeso molecular:420.1
