Receptor del factor de crecimiento de fibroblastos (FGFR)
Los inhibidores de FGFR (receptores del factor de crecimiento de fibroblastos) son terapias dirigidas que bloquean la actividad de los FGFR, los cuales están involucrados en la proliferación celular, diferenciación y angiogénesis. La señalización de FGFR contribuye a la formación de nuevos vasos sanguíneos en los tumores, promoviendo su crecimiento y supervivencia. Inhibir FGFR puede, por lo tanto, reducir la angiogénesis y la progresión tumoral. En CymitQuimica, ofrecemos una gama de inhibidores de FGFR de alta calidad para apoyar su investigación en cáncer, biología del desarrollo y angiogénesis.
Se han encontrado 180 productos de "Receptor del factor de crecimiento de fibroblastos (FGFR)"
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FGFR2-IN-3 hydrochloride
CAS:FGFR2-IN-3 hydrochloride is a selective, orally active FGFR2 inhibitor.Fórmula:C28H25ClFN7O2Forma y color:SolidPeso molecular:546.0FIIN-3
CAS:FIIN-3 is an irreversible inhibitor of FGFR.Fórmula:C34H36Cl2N8O4Pureza:97.63% - 98.92%Forma y color:SolidPeso molecular:691.61H3B-6527
CAS:H3B-6527 Is a Potent and Selective Inhibitor of FGFR4 in FGF19-Driven Hepatocellular Carcinoma, with antineoplastic activity.Fórmula:C29H34Cl2N8O4Pureza:97.45%Forma y color:SolidPeso molecular:629.54Ref: TM-T7738
1mg66,00€5mg160,00€10mg260,00€25mg502,00€50mg710,00€100mg1.009,00€1mL*10mM (DMSO)268,00€PRN1371
CAS:PRN1371 is a specific and potent FGFR1-4 and CSF1R inhibitor (IC50s: 0.6/1.3/4.1/19.3/8.1 nM for FGFR1/2/3/4 and CSF1R).Fórmula:C26H30Cl2N6O4Pureza:98.65%Forma y color:SolidPeso molecular:561.46Ref: TM-TQ0015
1mg77,00€2mg100,00€5mg166,00€10mg289,00€25mg492,00€50mg710,00€100mg973,00€1mL*10mM (DMSO)200,00€Fisogatinib
CAS:Fisogatinib (BLU-554) is a highly potent, selective, and orally active FGFR4 inhibitor.Cost-effective and quality-assured.Fórmula:C24H24Cl2N4O4Pureza:99.27% - ≥95%Forma y color:SolidPeso molecular:503.38Ref: TM-T3456
1mg50,00€5mg114,00€10mg167,00€25mg294,00€50mg444,00€100mg670,00€500mg1.341,00€1mL*10mM (DMSO)127,00€SU4984
CAS:SU4984 is a cell-permeable, ATP-competitive and reversible inhibitor of the fibroblast growth factor receptor 1 (FGFR1).Fórmula:C20H19N3O2Pureza:97.20%Forma y color:SolidPeso molecular:333.38PF 477736
CAS:PF 477736 (PF-736,PF-00477736) is a specifc, effective and ATP-competitive Chk1 inhibitor (Ki: 0.49 nM ) and also inhibits FGFR3, Aurora-A, VEGFR2, Flt3, Fms (Fórmula:C22H25N7O2Pureza:97.58% - 99.94%Forma y color:SolidPeso molecular:419.48SU 5402
CAS:SU 5402 is a potent multi-targeted receptor tyrosine kinase inhibitor with IC50 of 20 nM, 30 nM, and 510 nM for VEGFR2, FGFR1, and PDGF-Rβ, respectively.Fórmula:C17H16N2O3Pureza:98.91% - 99.64%Forma y color:Yellow-Green SolidPeso molecular:296.32ASP5878
CAS:ASP5878 potently inhibited the tyrosine kinase activities of recombinant FGFR1, 2, 3, and 4 with IC50 values of 0.47, 0.60, 0.74, and 3.5 nmol/L.Fórmula:C18H19F2N5O4Pureza:99.8% - 99.89%Forma y color:SolidPeso molecular:407.37GW786034B
CAS:Pazopanib HCl (Votrient) inhibits VEGFR1-3, PDGFR, FGFR, c-Kit, c-Fms with IC50 range 10-146 nM in cell-free assays.Fórmula:C21H23N7O2S·HClPureza:99.87%Forma y color:SolidPeso molecular:473.98LY2874455
CAS:LY2874455 has been used in trials studying the treatment of Advanced Cancer.Fórmula:C21H19Cl2N5O2Pureza:97.22% - 99.46%Forma y color:SolidPeso molecular:444.31Ref: TM-T2361
1mg47,00€5mg92,00€10mg145,00€25mg281,00€50mg447,00€100mg670,00€200mg888,00€1mL*10mM (DMSO)101,00€Roblitinib
CAS:Roblitinib (FGF-401), an FGFR4 inhibitor, potentially blocks tumor growth by halting cell proliferation and survival.Fórmula:C25H30N8O4Pureza:97.27% - 99%Forma y color:SolidPeso molecular:506.56Erdafitinib
CAS:Erdafitinib (JNJ-42756493) is a quinoxaline derivative compound, acts on FGFR1/2/3/4.Fórmula:C25H30N6O2Pureza:97.00% - 99.36%Forma y color:SolidPeso molecular:446.54PD168393
CAS:PD168393 is an irreversible EGFR inhibitor (IC50: 0.70 nM), irreversibly alkylate Cys-773; inactive against PKC, FGFR, PDGFR, and insulin.Fórmula:C17H13BrN4OPureza:99.13% - 99.83%Forma y color:SolidPeso molecular:369.22Ref: TM-T6932
1mg37,00€2mg50,00€5mg63,00€10mg94,00€25mg146,00€50mg210,00€100mg294,00€1mL*10mM (DMSO)52,00€EOC317
CAS:EOC317 (ACTB-1003) is an oral kinase inhibitor (IC50: 6/2/4 nM, for FGFR1/VEGFR2/Tie-2).Fórmula:C27H26F5N7O3Pureza:98.00% - 99.26%Forma y color:SolidPeso molecular:591.53Lenvatinib mesylate
CAS:Lenvatinib mesylate (E7080 (mesylate)) is an oral and multi-targeted inhibitor of VEGFR1-3, FGFR1-4, PDGFR, KIT, and RET, with potent antitumor activities.Fórmula:C22H23ClN4O7SPureza:99.03% - 99.79%Forma y color:SolidPeso molecular:522.96Derazantinib
CAS:Derazantinib (ARQ-087) is a potent, ATP-competitive, orally active tyrosine kinase inhibitor.Cost-effective and quality-assured.Fórmula:C29H29FN4OPureza:99.71%Forma y color:SolidPeso molecular:468.57Ref: TM-TQ0228
1mg50,00€5mg110,00€10mg160,00€25mg258,00€50mg380,00€100mg567,00€200mg805,00€1mL*10mM (DMSO)118,00€Zoligratinib
CAS:Zoligratinib (CH5183284) is a selective and orally available FGFR inhibitor, which is for FGFR1, FGFR2, FGFR3, and FGFR4, respectively.Fórmula:C20H16N6OPureza:95.28% - 99.51%Forma y color:SolidPeso molecular:356.38KW-2449
CAS:KW-2449 is a multiple-targeted inhibitor, mostly for Flt3, modestly effective to Bcr-Abl, FGFR1, and Aurora A; little inhibitory on PDGFRβ, IGF-1R, EGFR.Fórmula:C20H20N4OPureza:98.43% - 99.69%Forma y color:SolidPeso molecular:332.4Orantinib
CAS:Orantinib (NSC 702827) , a excellent effective against PDGFR autophosphorylation with Ki of 8 nM, also highly inhibits Flk-1 and FGFR1 trans-phosphorylation.Fórmula:C18H18N2O3Pureza:98.92% - 99.52%Forma y color:SolidPeso molecular:310.35
