Receptor del factor de crecimiento de fibroblastos (FGFR)
Los inhibidores de FGFR (receptores del factor de crecimiento de fibroblastos) son terapias dirigidas que bloquean la actividad de los FGFR, los cuales están involucrados en la proliferación celular, diferenciación y angiogénesis. La señalización de FGFR contribuye a la formación de nuevos vasos sanguíneos en los tumores, promoviendo su crecimiento y supervivencia. Inhibir FGFR puede, por lo tanto, reducir la angiogénesis y la progresión tumoral. En CymitQuimica, ofrecemos una gama de inhibidores de FGFR de alta calidad para apoyar su investigación en cáncer, biología del desarrollo y angiogénesis.
Se han encontrado 180 productos de "Receptor del factor de crecimiento de fibroblastos (FGFR)"
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Fisogatinib
CAS:Fisogatinib (BLU-554) is a highly potent, selective, and orally active FGFR4 inhibitor.Cost-effective and quality-assured.Fórmula:C24H24Cl2N4O4Pureza:99.27% - ≥95%Forma y color:SolidPeso molecular:503.38Ref: TM-T3456
1mg50,00€5mg114,00€10mg167,00€25mg294,00€50mg444,00€100mg670,00€500mg1.341,00€1mL*10mM (DMSO)127,00€Masitinib mesylate
CAS:Masitinib mesylate (AB-1010 mesylate) is a selective and orally bioavailable c-Kit inhibitor (IC50 of 200 nM,540/800 nM,510 nM for human recombinant c-Kit;Fórmula:C29H34N6O4S2Pureza:97.67% - 98.44%Forma y color:SolidPeso molecular:594.75KHS 101
CAS:KHS101 is a novel inhibitor of transforming acidic coiled-coil protein 3 (TACC3). It is a selective inducer of neuronal differentiation.
Fórmula:C18H21N5SPureza:99.63%Forma y color:SolidPeso molecular:339.46Ferulic acid sodium
CAS:Ferulic acid sodium (Sodium ferulic) is an agent used in the treatment of cardiovascular and cerebrovascular diseases and to prevent thrombosis.Fórmula:C10H9NaO4Pureza:99.58%Forma y color:White Crystalline PowderPeso molecular:216.16R1530
CAS:R1530 is a multikinase inhibitor with antineoplastic and antiangiogenesis activities.Fórmula:C18H14ClFN4OPureza:98.422%Forma y color:SolidPeso molecular:356.78Ref: TM-TQ0317
1mg39,00€2mg52,00€5mg84,00€10mg130,00€25mg264,00€50mg423,00€100mg640,00€1mL*10mM (DMSO)93,00€Alofanib
CAS:Alofanib (RPT835) selectively inhibits FGFR2 in KATO III cells with IC50 <10 nM; doesn’t affect FGFR1/3 or FGF2-FGFR2 binding.Fórmula:C19H15N3O6SPureza:99.53% - 99.81%Forma y color:SolidPeso molecular:413.4KW-2449
CAS:KW-2449 is a multiple-targeted inhibitor, mostly for Flt3, modestly effective to Bcr-Abl, FGFR1, and Aurora A; little inhibitory on PDGFRβ, IGF-1R, EGFR.Fórmula:C20H20N4OPureza:98.43% - 99.69%Forma y color:SolidPeso molecular:332.4Nintedanib esylate
CAS:Nintedanib esylate (BIBF 1120 esylate) is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/βFórmula:C31H33N5O4·C2H6O3SPureza:99.43% - 99.98%Forma y color:SolidPeso molecular:649.76FIIN-2
CAS:FIIN-2, an irreversible, pan-FGFR inhibitor, inhibits FGFR1/2/3/4 with IC50 of 3.09 nM, 4.3 nM, 27 nM and 45.3 nM, respectively.Fórmula:C35H38N8O4Pureza:97.82% - 99.65%Forma y color:Crystalline SolidPeso molecular:634.73LY2874455
CAS:LY2874455 has been used in trials studying the treatment of Advanced Cancer.Fórmula:C21H19Cl2N5O2Pureza:97.22% - 99.46%Forma y color:SolidPeso molecular:444.31Ref: TM-T2361
1mg47,00€5mg92,00€10mg145,00€25mg281,00€50mg447,00€100mg670,00€200mg888,00€1mL*10mM (DMSO)101,00€Erdafitinib
CAS:Erdafitinib (JNJ-42756493) is a quinoxaline derivative compound, acts on FGFR1/2/3/4.Fórmula:C25H30N6O2Pureza:97.00% - 99.36%Forma y color:SolidPeso molecular:446.54ASP5878
CAS:ASP5878 potently inhibited the tyrosine kinase activities of recombinant FGFR1, 2, 3, and 4 with IC50 values of 0.47, 0.60, 0.74, and 3.5 nmol/L.Fórmula:C18H19F2N5O4Pureza:99.8% - 99.89%Forma y color:SolidPeso molecular:407.37AZD4547
CAS:AZD4547 is an FGFR family inhibitor, and is able to act on FGFR1, FGFR2, FGFR3 and FGFR4. IC50:165 nM).Cost-effective and quality-assured.Fórmula:C26H33N5O3Pureza:99.37% - 99.88%Forma y color:SolidPeso molecular:463.57Ref: TM-T1948
2mg37,00€5mg50,00€10mg59,00€25mg84,00€50mg107,00€100mg147,00€200mg207,00€500mg348,00€1mL*10mM (DMSO)52,00€CHIR-98014
CAS:CHIR-98014 (CT98014) is a selective GSK3 inhibitor; potentiate insulin activation of glucose transport and utilization in vitro and in vivo.Fórmula:C20H17Cl2N9O2Pureza:97.25% - 99.59%Forma y color:SolidPeso molecular:486.31Ref: TM-T2608
5mg71,00€10mg102,00€25mg205,00€50mg334,00€100mg537,00€500mg1.134,00€1mL*10mM (DMSO)A consultarPD173074
CAS:PD173074 inhibits FGFR1 (IC50: 25 nM) and VEGFR2 (100-200 nM); ~1000x more selective for FGFR1 over PDGFR/c-Src.Fórmula:C28H41N7O3Pureza:98.15% - 98.21%Forma y color:Yellow SolidPeso molecular:523.67Ref: TM-T2642
5mg40,00€10mg54,00€25mg94,00€50mg133,00€100mg210,00€200mg371,00€500mg620,00€1mL*10mM (DMSO)56,00€SU 5402
CAS:SU 5402 is a potent multi-targeted receptor tyrosine kinase inhibitor with IC50 of 20 nM, 30 nM, and 510 nM for VEGFR2, FGFR1, and PDGF-Rβ, respectively.Fórmula:C17H16N2O3Pureza:98.91% - 99.64%Forma y color:Yellow-Green SolidPeso molecular:296.32PD-161570
CAS:PD-161570 is a potent and ATP-competitive human FGF-1 receptor inhibitor with an IC50 of 39.9 nM and a Ki of 42 nM.Fórmula:C26H35Cl2N7OPureza:99.92%Forma y color:SolidPeso molecular:532.51Ref: TM-T23127
1mg34,00€5mg96,00€10mg141,00€25mg289,00€50mg465,00€100mg662,00€200mg888,00€1mL*10mM (DMSO)118,00€XL 999
CAS:Tyrosine kinase-IN-1 is a multi-targeted tyrosine kinase inhibitor（KDR, Flt-1, FGFR1 and PDGFRα with IC50s of 4nM, 20nM, 4nM, 2 nM ,respectively）Fórmula:C26H28FN5OPureza:98.24% - 99.55%Forma y color:SolidPeso molecular:445.53PD-166866
CAS:PD-166866 is a selective FGFR tyrosine kinase inhibitor.Fórmula:C20H24N6O3Pureza:98.29%Forma y color:SolidPeso molecular:396.44BO-264
CAS:BO-264 is a highly potent and orally active inhibitor of transforming acidic coiled-coil 3 (TACC3, IC50 of 188 nM and a Kd of 1.5 nM).Fórmula:C18H19N5O3Pureza:98.03% - 99.81%Forma y color:SolidPeso molecular:353.38
