Receptor del factor de crecimiento de fibroblastos (FGFR)
Los inhibidores de FGFR (receptores del factor de crecimiento de fibroblastos) son terapias dirigidas que bloquean la actividad de los FGFR, los cuales están involucrados en la proliferación celular, diferenciación y angiogénesis. La señalización de FGFR contribuye a la formación de nuevos vasos sanguíneos en los tumores, promoviendo su crecimiento y supervivencia. Inhibir FGFR puede, por lo tanto, reducir la angiogénesis y la progresión tumoral. En CymitQuimica, ofrecemos una gama de inhibidores de FGFR de alta calidad para apoyar su investigación en cáncer, biología del desarrollo y angiogénesis.
Se han encontrado 170 productos de "Receptor del factor de crecimiento de fibroblastos (FGFR)"
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FGFR1 inhibitor-16
CAS:<p>FGFR1inhibitor-16 (Compound 89) functions as an FGFR1 inhibitor, demonstrating an inhibition rate of 53.00% at a concentration of 50 μM and 24.95% at 10 μM. It is utilized in tumor research.</p>Fórmula:C16H9N5O3SForma y color:SolidPeso molecular:351.339FGFR1 inhibitor-15
CAS:<p>FGFR1inhibitor-15 (Compound 23) is an FGFR1 inhibitor with an IC50 value of 27 μM, useful for tumor research.</p>Fórmula:C17H13FN4OForma y color:SolidPeso molecular:308.31FGFR2/3-IN-2
CAS:<p>FGFR2/3-IN-2 (compound 10) is an orally active inhibitor targeting FGFR2 and FGFR3. It exhibits IC50 values of 3.7 nM for FGFR2 and 31.2 nM for FGFR3, with a pre-incubation time of 1 hour. FGFR2/3-IN-2 demonstrates selectivity over FGFR1/4 and other kinases, and does not cause diarrhea or increased serum phosphate in vivo. In the SNU-16 gastric cancer model, FGFR2/3-IN-2 can induce tumor stasis or regression.</p>Fórmula:C29H23FN6O3Forma y color:SolidPeso molecular:522.53TYRA-300
CAS:<p>TYRA-300 is an oral and selective FGFR3 inhibito, in the Ba/F3 cell line for the treatment of metastatic uroepithelial carcinomas (mUCs) and chondrodysplasia.</p>Fórmula:C25H24Cl2N6O3SPureza:99.66%Forma y color:SolidPeso molecular:559.47FGFR-IN-16
CAS:<p>FGFR-IN-16 (compound 7N) is a potent inhibitor of FGFR1, FGFR2, and FGFR4, exhibiting IC50 values of 8 nM, 4 nM, and 3.8 nM respectively. It plays a crucial role in cancer research.</p>Fórmula:C30H27Cl2N7O4Forma y color:SolidPeso molecular:620.49FGFR-IN-15
<p>FGFR-IN-15 (compound 18i) acts as a pan-FGFR inhibitor, exhibiting potent inhibitory activity against FGFR1-4.</p>Fórmula:C22H23N5O5SForma y color:SolidPeso molecular:469.51FGFR4-IN-4
CAS:<p>FGFR4-IN-4 is a FGFR4 inhibitor with anti-tumor activity.</p>Fórmula:C28H32Cl2N6O5Pureza:98%Forma y color:SolidPeso molecular:603.5PNU-145156E
CAS:<p>PNU-145156E is a noncytotoxic molecule inhibiting growth and angiogenic factors, suppress tumor angiogenesis, support anti-angiogenic research strategies.</p>Fórmula:C45H40N10O17S4Forma y color:SolidPeso molecular:1121.12Fanregratinib
CAS:<p>Fanregratinib is a fibroblast growth factor receptor (FGFR) tyrosine kinase inhibitor.</p>Fórmula:C27H33ClN6O2Forma y color:SolidPeso molecular:509.04FGFR1 inhibitor-10
CAS:<p>FGFR1 inhibitor-10 (Compound 4i), with an IC50 of 28 nM, effectively inhibits FGFR1 phosphorylation.</p>Fórmula:C26H30F3N7O2SPureza:98%Forma y color:SolidPeso molecular:561.62Ref: TM-T79686
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