ALK
Los inhibidores de ALK son compuestos que específicamente atacan e inhiben la quinasa del linfoma anaplásico (ALK), una tirosina quinasa receptora involucrada en el desarrollo y progresión de ciertos tipos de cáncer, incluyendo el cáncer de pulmón de células no pequeñas y el neuroblastoma. Al inhibir ALK, estos compuestos bloquean las vías de señalización que promueven el crecimiento y la supervivencia de las células tumorales. En CymitQuimica, ofrecemos inhibidores de ALK para apoyar su investigación en oncología, terapias dirigidas contra el cáncer y transducción de señales.
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R-268712
CAS:R-268712 is a potent ALK5 inhibitor with a 2.5 nM IC50, also targeting TGF-β type I receptor orally.Fórmula:C20H18FN5OPureza:99.61%Forma y color:SolidPeso molecular:363.39Ref: TM-T16708
1mg47,00€5mg87,00€10mg137,00€25mg264,00€50mg399,00€100mg567,00€200mg805,00€1mL*10mM (DMSO)97,00€TGFBR1-IN-1
CAS:TGFBR1-IN-1 is an inhibitor of ALK5 (IC50 of 10-100 nM).Fórmula:C23H17N5O2SPureza:98%Forma y color:SolidPeso molecular:427.48Ref: TM-T13138
25mg1.444,00€50mg1.882,00€100mg2.375,00€LDN-193189 Tetrahydrochloride
CAS:LDN193189 is a BMPI receptor inhibitor, blocking ALK2 and ALK3 effectively, while weak on ALK4, ALK5, ALK7.Fórmula:C25H26Cl4N6Pureza:98.21%Forma y color:SolidPeso molecular:552.33Ref: TM-T63897
1mg35,00€5mg74,00€10mg96,00€25mg150,00€50mg225,00€100mg334,00€ALKBH5-IN-5
CAS:ALKBH5-IN-5 is a highly selective, potent and covalently binding ALKBH5 inhibitor that alters m6A levels on mRNA, induces apoptosis, antitumo.Fórmula:C13H13NO3Pureza:99.54%Forma y color:SoildPeso molecular:231.25Ref: TM-T203011
5mg35,00€10mg48,00€25mg88,00€50mg127,00€100mg188,00€200mg283,00€1mL*10mM (DMSO)52,00€A 77-01
CAS:A 77-01 is a potent inhibitor of TGF-(beta) type I receptor superfamily activin-like kinase ALK5 with IC50 of 25 nM.Fórmula:C18H14N4Pureza:98.82% - ≥95%Forma y color:SolidPeso molecular:286.33Ref: TM-T2098
1mg48,00€5mg95,00€10mg140,00€25mg246,00€50mg359,00€100mg507,00€1mL*10mM (DMSO)103,00€ALK-IN-27
CAS:Neladalkib (NVL-655) is an ALK inhibitor with antitumor activity for the study of non-small cell cancers.Fórmula:C23H22ClFN6OPureza:99.71%Forma y color:SolidPeso molecular:452.91Ref: TM-T83146
1mg55,00€5mg122,00€10mg188,00€25mg346,00€50mg528,00€1mL*10mM (DMSO)145,00€GW788388
CAS:GW788388 is a potent and selective inhibitor of ALK5, also inhibits TGF-(beta) type II receptor and activin type II receptor activities.Fórmula:C25H23N5O2Pureza:98.03% - 99.58%Forma y color:SolidPeso molecular:425.48Ref: TM-T1800
5mg64,00€10mg95,00€25mg169,00€50mg266,00€100mg393,00€500mg914,00€1mL*10mM (DMSO)65,00€ML347
CAS:ML347 (LDN 193719)(DN193719) is a highly specific ALK1/2 inhibitor ( IC50: 46/32 nM), and the selectivity for ALK2 is >300-fold than ALK3.Fórmula:C22H16N4OPureza:99.30% - ≥95%Forma y color:SolidPeso molecular:352.39Ref: TM-T1943
2mg39,00€5mg57,00€10mg85,00€25mg157,00€50mg274,00€100mg465,00€5-phenylthieno[2,3-d]pyrimidin-4-amine
CAS:5-phenylthieno[2,3-d]pyrimidin-4-amine is a heterocycle that inhibits enzymes like kinases, may treat diseases.Fórmula:C12H9N3SPureza:97%Forma y color:SolidPeso molecular:227.29Ref: TM-T50042
2mg46,00€5mg64,00€10mg95,00€25mg145,00€50mg212,00€100mg319,00€200mg455,00€1mL*10mM (DMSO)64,00€RepSox
CAS:RepSox (ALK5 Inhibitor II) is a TGFβR-1/ALK5 inhibitor that selectively inhibits the binding of ATP to ALK5 and the autophosphorylation of ALK5 (IC50=23/4 nM).Fórmula:C17H13N5Pureza:98.8% - 99.73%Forma y color:SolidPeso molecular:287.32Ref: TM-T6337
1mg35,00€2mg48,00€5mg66,00€10mg85,00€25mg123,00€50mg172,00€100mg255,00€500mg630,00€1mL*10mM (DMSO)72,00€Brigatinib
CAS:Brigatinib (AP-26113) is a highly potent and selective ALK inhibitor.Fórmula:C29H39ClN7O2PPureza:97.18% - >99.99%Forma y color:SolidPeso molecular:584.09Ref: TM-T3621
2mg35,00€5mg50,00€10mg66,00€25mg96,00€50mg114,00€100mg166,00€200mg240,00€500mg406,00€SM 16
CAS:SM 16 is a ALK5/ALK4 kinase inhibitor (Ki: 10/1.5 nM).Fórmula:C25H26N4O3Pureza:99.72%Forma y color:SolidPeso molecular:430.5Ref: TM-T4975
1mg46,00€5mg87,00€10mg153,00€25mg264,00€50mg427,00€100mg630,00€1mL*10mM (DMSO)97,00€IN-1130
CAS:IN-1130: ALK5 inhibitor, IC50 - 5.3 nM (Smad3), 36 nM (casein), 4.3 μM (p38α MAPK).Fórmula:C25H20N6OPureza:99.79%Forma y color:SolidPeso molecular:420.47Ref: TM-T15572
5mg52,00€10mg90,00€25mg170,00€50mg259,00€100mg375,00€1mL*10mM (DMSO)58,00€FDA-Approved Kinase Inhibitor Library
A unique collection of 263 kinase inhibitors/regulators for specific targeting of kinases, ready for high-throughput screening and high-content screening.Forma y color:LiquidRef: TM-L1610
1mgA consultar30μL*10mM (DMSO)A consultar50μL*10mM (DMSO)A consultar100μL*10mM (DMSO)A consultar250μL*10mM (DMSO)A consultarKinase Inhibitor Library
A unique collection of 2720 kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;Forma y color:Odour SolidRef: TM-L1600
1mgA consultar30μL*10mM (DMSO)A consultar50μL*10mM (DMSO)A consultar100μL*10mM (DMSO)A consultar250μL*10mM (DMSO)A consultarN-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-2-bromoaniline
CAS:Compound 12d is a potent ALK5 inhibitor with an IC50 of 7nM.Fórmula:C22H18BrN7Pureza:99.935%Forma y color:SolidPeso molecular:460.33Ref: TM-T9837
1mg87,00€5mg192,00€10mg284,00€25mg452,00€50mg645,00€100mg867,00€200mg1.159,00€1mL*10mM (DMSO)226,00€Zotizalkib
CAS:TPX-0131: potent, selective, CNS-ready, oral ALK inhibitor (WT IC50: 1.4nM, G1202R/L1196M IC50: 0.3nM) with robust antitumor effects.Fórmula:C21H20F3N5O3Pureza:98.7%Forma y color:SolidPeso molecular:447.41Ref: TM-T9414
1mg127,00€5mg304,00€10mg487,00€25mg938,00€50mg1.473,00€100mg2.072,00€200mg2.802,00€1mL*10mM (DMSO)334,00€DA-0157
CAS:DA-0157 is an orally active inhibitor targeting EGFR and ALK, designed to overcome resistance mutations in non-small cell lung cancer (NSCLC). It effectively inhibits the proliferation of Ba/F3-EGFR Del19/T790M/C797S (IC50= 6.9 nM), Ba/F3-EGFR WT (IC50= 0.83 μM), Ba/F3-EML4-ALK-L1196M (IC50= 5.5 nM), and Ba/F3-EML4-ALK (IC50= 7.4 nM). Additionally, DA-0157 inhibits CYP2D6 with an IC50 of 5.26 μM and demonstrates antitumor activity in mouse models.Fórmula:C31H43BrN7O2PForma y color:SolidPeso molecular:656.597Ref: TM-T205118
10mgA consultar50mgA consultarALK-IN-21
CAS:ALK-IN-21 (B10) inhibits ALK WT (IC50: 4.59nM), L1196M (2.07nM), G1202R (5.95nM); curbs Karpas299, H2228 cell growth; for ALCL research.Fórmula:C35H45ClN6O6S4Forma y color:SolidPeso molecular:809.48Ref: TM-T74522
25mg1.444,00€50mg1.882,00€100mg2.375,00€CH5424802 analog
CAS:CH5424802 analog is a selective ALK inhibitor capable of blocking the resistant gatekeeper mutant.Fórmula:C28H30N4O2Pureza:98.96%Forma y color:SolidPeso molecular:454.56Ref: TM-T9224
1mg131,00€5mg286,00€10mg430,00€25mg710,00€50mg998,00€100mg1.349,00€1mL*10mM (DMSO)343,00€
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