ALK
Los inhibidores de ALK son compuestos que específicamente atacan e inhiben la quinasa del linfoma anaplásico (ALK), una tirosina quinasa receptora involucrada en el desarrollo y progresión de ciertos tipos de cáncer, incluyendo el cáncer de pulmón de células no pequeñas y el neuroblastoma. Al inhibir ALK, estos compuestos bloquean las vías de señalización que promueven el crecimiento y la supervivencia de las células tumorales. En CymitQuimica, ofrecemos inhibidores de ALK para apoyar su investigación en oncología, terapias dirigidas contra el cáncer y transducción de señales.
Se han encontrado 136 productos de "ALK"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
CEP-28122 mesylate salt (1022958-60-6 free base)
CEP-28122 mesylate salt (1022958-60-6 free base) is a highly selective orally active ALK inhibitor (IC50: 1.9 nM in an enzyme-based TRF assay).Fórmula:C29H39ClN6O6SPureza:99.79%Forma y color:SolidPeso molecular:635.17ALK inhibitor 2
CAS:ALK inhibitor 2 is a new-type and selective inhibitor for the ALK kinase.Fórmula:C23H28ClN7O3SPureza:99.77% - >99.99%Forma y color:SolidPeso molecular:518.03Ascrinvacumab
CAS:Ascrinvacumab (PF-03446962): humanized IgG2 anti-ALK-1 antibody, Kd 7 nM, inhibits TGF-β, for HCC research.Pureza:SDS-PAGE:95% SEC-HPLC:98.18%Forma y color:LiquidPeso molecular:150 kDaALK inhibitor 1
CAS:ALK inhibitor 1 is a selective ALK kinase inhibitor.Fórmula:C23H28BrN7O3SPureza:98.27%Forma y color:SolidPeso molecular:562.48Ref: TM-T10285
1mg50,00€5mg110,00€10mg166,00€25mg323,00€50mg447,00€100mg610,00€1mL*10mM (DMSO)136,00€ZX-29
CAS:ZX-29: Strong ALK inhibitor; IC50 - ALK 2.1 nM, L1196M 1.3 nM, G1202R 3.9 nM; triggers autophagy; anti-cancer.Fórmula:C23H28ClN7O3SPureza:98.32%Forma y color:SolidPeso molecular:518.03Ref: TM-T13416
1mg92,00€5mg230,00€10mg364,00€25mg620,00€50mg848,00€100mg1.121,00€200mg1.510,00€1mL*10mM (DMSO)264,00€MS4078
CAS:MS4078 is an inhibitor and aplastic lymphoma kinase (ALK) PROTAC (degrader) based on Cereblon ligand, with a Kd of 19 nM for binding affinity to ALK.Fórmula:C45H52ClN9O8SPureza:98.74%Forma y color:SolidPeso molecular:914.47Ref: TM-T16153
1mg49,00€2mg66,00€5mg90,00€10mg152,00€25mg260,00€50mg416,00€100mg615,00€1mL*10mM (DMSO)152,00€ALK-IN-26
CAS:ALK-IN-26 is an ALK inhibitor with potential anticancer activity.ALK-IN-26 shows antiproliferative activity against glioblastoma.Fórmula:C24H23NO3SPureza:99.91%Forma y color:SoildPeso molecular:405.51F-1
CAS:F-1: Potent ALK/ROS1 inhibitor with 2.1-3.9 nM IC50s; suppresses p-ALK signaling.Fórmula:C22H27ClN8O3SPureza:97.66%Forma y color:SolidPeso molecular:519.02Ref: TM-T11254
1mg70,00€5mg133,00€10mg178,00€25mg299,00€50mg424,00€100mg587,00€200mg800,00€1mL*10mM (DMSO)165,00€ALK/ROS1-IN-3
ALK/ROS1-IN-3 (compound C01) is a dual inhibitor targeting ROS1 and ALK, with IC50 values of 42.3 nM for ROS1G2032R and 49.1 nM for ALKG1202R.Fórmula:C32H32N4O2Peso molecular:504.25253ALK-IN-9
CAS:ALK-IN-9 effectively inhibits cell growth with IC50 <0.2 nM for Ba/F3-EML4-ALK, KM12, KG-1.Fórmula:C20H21FN6O3Forma y color:SolidPeso molecular:412.425LDN 193688
CAS:LDN 193688 is a BMP kinase inhibitor preferential for the ALK2 site, acting by binding to the ALK site,progressive osseous fibrodysplasia.Fórmula:C22H16N4OPureza:99.48%Forma y color:SoildPeso molecular:352.39dALK-3
dALK-3 is a degrader of anaplastic lymphoma kinase (ALK) that effectively induces the degradation of EML4-ALK with a DC50 of 0.182 μM. It exhibits significant antiproliferative activity against H3122 cells and is applicable for tumor research.Fórmula:C39H45ClN7O5PForma y color:SolidPeso molecular:758.245ALK protein ligand-1
CAS:ALK protein ligand-1 (Compound A1) is an ALK protein ligand, acting as a ligand for the target protein in PROTACs, demonstrating inhibitory effects on ALK. It is also useful in the synthesis of AP-1.Fórmula:C24H29ClN6O3SForma y color:SolidPeso molecular:517.043M4K2234
CAS:M4K2234 (26b) inhibits ALK2/ALK5 (IC50: 5/2144 nM), used as a probe for ALK1/2 kinases in cancer research.Fórmula:C27H31FN4O2Pureza:99.99%Forma y color:SolidPeso molecular:462.56LAE-102
LAE-102 is a monoclonal antibody that acts as an antagonist of activin receptor II-A (ACTRIIA/ACVR2). It shows potential for research in the fields of endocrine and metabolic disorders, oncology, and respiratory diseases.Forma y color:Odour LiquidALK-IN-13
CAS:ALK-IN-13 is an ALK inhibitor.
Fórmula:C29H39ClN7O2PForma y color:SolidPeso molecular:584.12-Keto Crizotinib
CAS:2-Keto Crizotinib is an active lactam metabolite of crizotinib.Fórmula:C21H20Cl2FN5O2Pureza:98%Forma y color:SolidPeso molecular:464.32TL13-12
CAS:TL13-12 is a selective degrader of ALK-PROTAC and inhibits ALK activity (IC50: 0.69 nM).Fórmula:C45H53ClN10O10SPureza:98%Forma y color:SolidPeso molecular:961.49TL13-110
CAS:Negative control for TL 13-112 . Displays no degradation of ALK in cell lines. Highly potent ALK inhibitor (IC50 = 0.34 nM).Fórmula:C49H62ClN9O9SForma y color:SolidPeso molecular:988.59INCB-000928
CAS:Zilurgisertib (INCB-000928) is a selective and potent ALK 2 inhibitor for the study of cancer and MF anemia.
Fórmula:C30H38N4O3Pureza:98.93%Forma y color:SolidPeso molecular:502.65FDA-Approved Kinase Inhibitor Library
A unique collection of 263 kinase inhibitors/regulators for specific targeting of kinases, ready for high-throughput screening and high-content screening.
Forma y color:LiquidKinase Inhibitor Library
A unique collection of 2720 kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;Forma y color:Odour SolidRef: TM-L1600
1mgA consultar30μL*10mM (DMSO)A consultar50μL*10mM (DMSO)A consultar100μL*10mM (DMSO)A consultar250μL*10mM (DMSO)A consultarALK-IN-12
CAS:ALK-IN-12: potent ALK inhibitor (IC50: 0.18 nM), affects IGF1R and InsR (IC50: 20.3/90.6 nM), potential for cancer therapy.Fórmula:C24H30ClN6O2PForma y color:SolidPeso molecular:500.97SIAIS164018 hydrochloride
SIAIS164018 hydrochloride is a PROTAC-based degrader targeting ALK and EGFR, exhibiting IC50 values of 2.5 nM for ALK and 6.6 nM for ALK G1202R.Fórmula:C43H49Cl2N10O7PPureza:98%Forma y color:SolidPeso molecular:919.79ALK5 Inhibitor II (hydrochloride)
CAS:ALK5 Inhibitor II has IC50s: 4 nM (auto), 18 nM (TGF-β assay), 23 nM (binding, HepG2).Fórmula:C17H13N5·HClPureza:98%Forma y color:SolidPeso molecular:323.8TL13-22
CAS:TL13-22 is a potent inhibitor of ALK and does not lead to degradation of ALK proteins.TL13-22 is often used as a negative control for TL13-12 .Fórmula:C45H55ClN10O9SPureza:99.13%Forma y color:SolidPeso molecular:947.5ALK-IN-29
ALK-IN-29 (compound 4c) exhibits inhibitory effects on tyrosine protein kinases such as ALK, CDK2/CyclinE1, and FAK, with the strongest inhibition observed against ALK kinase, displaying a 40.63% inhibition rate at a concentration of 10 μM. ALK-IN-29 is applicable in cancer research.Fórmula:C29H32FN3OForma y color:SolidPeso molecular:457.58PROTAC ALK degrader-3
PROTAC ALK degrader-3 (4B) is an orally active PROTAC-based ALK degrader, efficiently inducing sustained degradation of ALK fusion protein and significant inhibition of downstream pathways in Karpas 299 cells with an IC50 of 119.33 nM. This compound exhibits antitumor activity.Fórmula:C50H60ClN9O7SForma y color:SolidPeso molecular:966.59TL13-112
CAS:TL13-112 is a selective degrader of ALK-PROTAC and inhibits ALK activity (IC50: 0.14 nM).Fórmula:C49H60ClN9O10SPureza:98%Forma y color:SolidPeso molecular:1002.57Multi-kinase-IN-6
Multi-kinase-IN-6 (compound 10e) is a multikinase inhibitor that effectively impedes the activity of TrkA, ALK2, c-KIT, EGFR, PIM1, CK2α, CHK1, and CDK2.Pureza:98%Forma y color:Odour SolidLDN-193189 2HCl
CAS:LDN-193189 2HCl inhibits BMP signaling (ALK1/2/3/6), IC50: 0.8-16.7 nM; selective over TGF-β by 200-fold in C2C12 cells.
Fórmula:C25H24Cl2N6Pureza:99.78%Forma y color:SolidPeso molecular:479.4ALK/ROS1-IN-5
ALK/ROS1-IN-5 (compound X4) is a selective inhibitor of ALK and ROS1 kinases, with IC50 values of 0.512 μM for ALK and 0.766 μM for ROS1. It inhibits H2228 cells with an IC50 of 0.034 μM and induces apoptosis in cancer cells in a dose-dependent manner. Additionally, ALK/ROS1-IN-5 effectively suppresses the expression of p-ALK and p-ERK in cancer cells.
Fórmula:C32H28F2N4O3Forma y color:SolidPeso molecular:554.586CPD-1224
CAS:CPD-1224, an oral ALK inhibitor derivative, binds cereblon, targets EML4-ALK fusions, and degrades ALK plus L1196M/G1202R mutants.Fórmula:C43H47ClN8O7SForma y color:SolidPeso molecular:855.4ALKBH5-IN-5
CAS:ALKBH5-IN-5 is a highly selective, potent and covalently binding ALKBH5 inhibitor that alters m6A levels on mRNA, induces apoptosis, antitumo.Fórmula:C13H13NO3Pureza:99.54%Forma y color:SoildPeso molecular:231.25Ref: TM-T203011
5mg34,00€10mg46,00€25mg84,00€50mg120,00€100mg178,00€200mg268,00€1mL*10mM (DMSO)49,00€MS4077
CAS:MS4077 is an degrader of anaplastic lymphoma kinase (ALK) PROTAC(Kd of 37 nM for binding affinity to ALK).Fórmula:C55H72ClN9O13SPureza:98%Forma y color:SolidPeso molecular:1134.73LDN-193189 Tetrahydrochloride
CAS:LDN193189 is a BMPI receptor inhibitor, blocking ALK2 and ALK3 effectively, while weak on ALK4, ALK5, ALK7.Fórmula:C25H26Cl4N6Pureza:98.21%Forma y color:SolidPeso molecular:552.33EW-7195
CAS:EW-7195 inhibits ALK5/TGFβR1 (>300x selective over p38α) with 4.83 nM IC50, blocking TGF-β1 signaling, EMT, and breast cancer lung metastasis.
Fórmula:C23H18N8Pureza:98.76%Forma y color:SolidPeso molecular:406.44LDN193189
CAS:LDN193189 blocks BMP signaling by inhibiting ALK2/3; IC50: ALK1/2/3/6 = 0.8/0.8/5.3/16.7 nM.Fórmula:C25H22N6Pureza:98% - 99.86%Forma y color:SolidPeso molecular:406.48Ceritinib dihydrochloride
CAS:Ceritinib dihydrochloride (LDK378 dihydrochloride) is a selective, orally bioavailable, ATP-competitive inhibitor of ALK tyrosine kinase with antitumour effect.Fórmula:C28H38Cl3N5O3SPureza:99.85% - 99.99%Forma y color:SolidPeso molecular:631.06A 77-01
CAS:A 77-01 is a potent inhibitor of TGF-(beta) type I receptor superfamily activin-like kinase ALK5 with IC50 of 25 nM.Fórmula:C18H14N4Pureza:98.82% - ≥95%Forma y color:SolidPeso molecular:286.33Ref: TM-T2098
1mg40,00€2mg52,00€5mg86,00€10mg118,00€25mg200,00€50mg280,00€100mg394,00€200mg580,00€1mL*10mM (DMSO)95,00€GW788388
CAS:GW788388 is a potent and selective inhibitor of ALK5, also inhibits TGF-(beta) type II receptor and activin type II receptor activities.
Fórmula:C25H23N5O2Pureza:98.03% - 99.58%Forma y color:SolidPeso molecular:425.48ML347
CAS:ML347 (LDN 193719)(DN193719) is a highly specific ALK1/2 inhibitor ( IC50: 46/32 nM), and the selectivity for ALK2 is >300-fold than ALK3.Fórmula:C22H16N4OPureza:99.30% - ≥95%Forma y color:SolidPeso molecular:352.395-phenylthieno[2,3-d]pyrimidin-4-amine
CAS:5-phenylthieno[2,3-d]pyrimidin-4-amine is a heterocycle that inhibits enzymes like kinases, may treat diseases.Fórmula:C12H9N3SPureza:97%Forma y color:SolidPeso molecular:227.29Ref: TM-T50042
2mg46,00€5mg64,00€10mg95,00€25mg145,00€50mg212,00€100mg319,00€200mg455,00€1mL*10mM (DMSO)64,00€RepSox
CAS:RepSox (ALK5 Inhibitor II) is a TGFβR-1/ALK5 inhibitor that selectively inhibits the binding of ATP to ALK5 and the autophosphorylation of ALK5 (IC50=23/4 nM).Fórmula:C17H13N5Pureza:98.8% - 99.73%Forma y color:SolidPeso molecular:287.32Ref: TM-T6337
1mg34,00€2mg46,00€5mg63,00€10mg80,00€25mg116,00€50mg169,00€100mg241,00€500mg597,00€1mL*10mM (DMSO)69,00€Brigatinib
CAS:Brigatinib (AP-26113) is a highly potent and selective ALK inhibitor.
Fórmula:C29H39ClN7O2PPureza:97.18% - >99.99%Forma y color:SolidPeso molecular:584.09SM 16
CAS:SM 16 is a ALK5/ALK4 kinase inhibitor (Ki: 10/1.5 nM).Fórmula:C25H26N4O3Pureza:99.72%Forma y color:SolidPeso molecular:430.5ALK5-IN-10
CAS:Compound 12d is a potent ALK5 inhibitor with an IC50 of 7nM.Fórmula:C22H18BrN7Pureza:99.935%Forma y color:SolidPeso molecular:460.33Ref: TM-T9837
1mg93,00€5mg182,00€10mg269,00€25mg429,00€50mg610,00€100mg820,00€200mg1.099,00€1mL*10mM (DMSO)215,00€CH5424802 analog
CAS:CH5424802 analog is a selective ALK inhibitor capable of blocking the resistant gatekeeper mutant.Fórmula:C28H30N4O2Pureza:98.96%Forma y color:SolidPeso molecular:454.56Ref: TM-T9224
1mg124,00€5mg271,00€10mg408,00€25mg672,00€50mg945,00€100mg1.279,00€1mL*10mM (DMSO)324,00€DMH-1
CAS:DMH-1 is a BMP inhibitor that inhibits ALK1, ALK2, ALK3 and ALK6. DMH-1 promotes pluripotent stem cell differentiation. Cost-effective and quality-assured.
Fórmula:C24H20N4OPureza:98% - 99.92%Forma y color:SolidPeso molecular:380.44ALK kinase inhibitor-1
CAS:SAR348830 is an ALK inhibitor, targeting anaplastic lymphoma kinase.Fórmula:C28H32FN5O3SPureza:99.84%Forma y color:SolidPeso molecular:537.65A 83-01 sodium salt
CAS:A 83-01 sodium salt inhibits ALK5, ALK4, and ALK7 kinases with IC50s: 12, 45, 7.5 nM.Fórmula:C25H19N5NaSForma y color:SolidPeso molecular:444.51CEP-28122 mesylate salt
CEP-28122 mesylate, a diaminopyrimidine, selectively inhibits ALK with IC50 of 1.9 nM and exhibits antitumor effects.Fórmula:C29H39ClN6O6SForma y color:SolidPeso molecular:635.17Vactosertib Hydrochloride
CAS:Vactosertib Hydrochloride (EW-7197 Hydrochloride) is an ALK5 inhibitor, a TGF-β receptor I inhibitor with antimetastatic and anticancer effects.Fórmula:C22H19ClFN7Pureza:98.03%Forma y color:SolidPeso molecular:435.89Ref: TM-T15262
1mg34,00€5mg66,00€10mg92,00€25mg152,00€50mg230,00€100mg356,00€200mg522,00€1mL*10mM (DMSO)73,00€AZD-3463
CAS:AZD-3463 (ALK/IGF1R inhibitor) , an orally bioavailable ALK inhibitor (Ki: 0.75 nM), can inhibit IGF1R with equivalent potency.Fórmula:C24H25ClN6OPureza:99.13%Forma y color:SolidPeso molecular:448.95LDN-193189 HCl
CAS:LDN-193189 HCl (LDN193189 Hydrochloride) is a selective BMP type I receptor kinases inhibitor.Fórmula:C25H22N6·HClPureza:99.49% - 99.53%Forma y color:SolidPeso molecular:442.94Ref: TM-T6158
1mg35,00€2mg48,00€5mg70,00€10mg93,00€25mg156,00€50mg227,00€100mg378,00€200mg567,00€1mL*10mM (DMSO)86,00€Crizotinib acetate
CAS:Crizotinib is an oral c-met/HGFR tyrosine kinase inhibitor with potential cancer-fighting properties.Fórmula:C23H26Cl2FN5O3Forma y color:SolidPeso molecular:510.39SB 525334
CAS:SB-525334 is a potent and selective inhibitor of the TGF-β1R and ALK5 (IC50: 14.3 nM).Fórmula:C21H21N5Pureza:98.39% - ≥95%Forma y color:SolidPeso molecular:343.42Blu-782
CAS:Blu-782 (ALK2-IN-1) is a activin receptor-like kinase-2 (ALK2) inhibitor ( IC50 of <10 nM)
Fórmula:C31H42N6O4Pureza:99.51%Forma y color:SolidPeso molecular:562.7LDN-212854
CAS:LDN-212854 (BMP Inhibitor III), a novel BMP inhibitor, exhibits greater selectivity for BMP versus the TGF-β type I receptors.Fórmula:C25H22N6Pureza:98% - 98.71%Forma y color:SolidPeso molecular:406.48Ref: TM-T1900
1mg47,00€2mg62,00€5mg92,00€10mg172,00€25mg294,00€50mg439,00€100mg660,00€200mg945,00€1mL*10mM (DMSO)102,00€SB-431542
CAS:SB-431542 is an inhibitor of ALK5/TGF-β type I Receptor (IC50=94 nM) and is selective.Fórmula:C22H16N4O3Pureza:99.035% - >99.99%Forma y color:SolidPeso molecular:384.39Ensartinib hydrochloride
CAS:Ensartinib hydrochloride (X-396 dihydrochloride) is a potent new-generation ALK inhibitor with high activity against CNS metastases and a broad range of knownFórmula:C26H29Cl4FN6O3Pureza:98.73%Forma y color:SolidPeso molecular:634.36Ref: TM-T22324
1mg54,00€5mg114,00€10mg177,00€25mg356,00€50mg580,00€100mg888,00€1mL*10mM (DMSO)158,00€HG-14-10-04
CAS:HG-14-10-04 is a potent and specific ALK inhibitor.Fórmula:C29H34ClN7OPureza:99.75% - >99.99%Forma y color:SolidPeso molecular:532.08Ref: TM-T4015
1mg49,00€5mg92,00€10mg152,00€25mg222,00€50mg289,00€100mg409,00€200mg590,00€1mL*10mM (DMSO)111,00€CEP-28122
CAS:CEP-28122 is a highly potent and selective orally active ALK inhibitor.Fórmula:C28H35ClN6O3Pureza:99.87% - >99.99%Forma y color:SolidPeso molecular:539.07Vactosertib
CAS:Vactosertib (EW-7197) is an oral TGFBR1/ALK5 inhibitor with potential cancer-fighting properties.Fórmula:C22H18FN7Pureza:98.85% - 99.81%Forma y color:SolidPeso molecular:399.42CAY10594
CAS:CAY10594, a PLD2 inhibitor, mitigates acetaminophen liver damage via the p-GSK-3β/JNK pathway.Fórmula:C26H28N4O2Pureza:98%Forma y color:SolidPeso molecular:428.53LDN-214117
CAS:LDN-214117 is a potent and selective ALK2 inhibitor.
Fórmula:C25H29N3O3Pureza:98% - 99.82%Forma y color:SolidPeso molecular:419.52D4476
CAS:D4476 (Casein Kinase I Inhibitor) is an effective, selective, and cell-permeant CK1 (casein kinase 1) inhibitor( IC50=300 nM in a cell-free assay).Fórmula:C23H18N4O3Pureza:99.7% - 99.96%Forma y color:SolidPeso molecular:398.41Crizotinib hydrochloride
CAS:Crizotinib hydrochloride (PF-02341066 hydrochloride) is a novel inhibitor of anaplastic lymphoma kinase and c-Met(IC50s of 20 and 8 nM)Fórmula:C21H23Cl3FN5OPureza:98.73% - 98.87%Forma y color:SolidPeso molecular:486.8Ref: TM-T8399
5mg34,00€10mg50,00€25mg78,00€50mg94,00€100mg131,00€200mg162,00€500mg215,00€1mL*10mM (DMSO)56,00€Alectinib
CAS:Alectinib (RG-7853) is an ALK inhibitor that is selective, orally active, and ATP-competitive. Alectinib has antitumor activity. Cost-effective and quality-assured.Fórmula:C30H34N4O2Pureza:98% - 99.38%Forma y color:SolidPeso molecular:482.62Ref: TM-T1936
2mg47,00€5mg69,00€10mg87,00€50mg105,00€100mg168,00€200mg259,00€500mg437,00€1mL*10mM (DMSO)73,00€CEP-37440
CAS:CEP-37440 is an effective and specific Dual FAK/ALK inhibitor with IC50s of 120 nM(ALK cellular in 75% human plasma) and 2.3 nM (FAK).Fórmula:C30H38ClN7O3Pureza:98.86% - 99.98%Forma y color:SolidPeso molecular:580.12GSK1838705A
CAS:GSK1838705A: IGF-1R inhibitor (IC50=2.0nM), IR (1.6nM), ALK (0.5nM), minimal other kinase impact.Fórmula:C27H29FN8O3Pureza:98.89% - >99.99%Forma y color:SolidPeso molecular:532.57Entrectinib
CAS:Entrectinib (RXDX-101) is an orally Trk, ROS1, and ALK inhibitor. Entrectinib exhibits antitumor activity. Cost-effective and quality-assured.Fórmula:C31H34F2N6O2Pureza:98.03% - 99.61%Forma y color:SolidPeso molecular:560.64Ref: TM-T3678
2mg42,00€5mg59,00€10mg88,00€25mg111,00€50mg168,00€100mg283,00€500mg692,00€1mL*10mM (DMSO)69,00€Belizatinib
CAS:Belizatinib (TSR-011) is an effective, oral and dual inhibitor of ALK (IC50: 0.7 nM, wild-type recombinant ALK) and TRKA, TRKB, and TRKC.Fórmula:C33H44FN5O3Pureza:99.33% - 99.44%Forma y color:SolidPeso molecular:577.73Ref: TM-T4257
1mg40,00€2mg54,00€5mg93,00€10mg133,00€25mg259,00€50mg358,00€100mg500,00€1mL*10mM (DMSO)105,00€BIBF0775
CAS:BIBF0775 is a selective TGFβ type I receptor (Alk5) inhibitor (IC50: 34 nM).
Fórmula:C31H34N4O2Pureza:99.45% - 99.79%Forma y color:SolidPeso molecular:494.63Lorlatinib
CAS:Lorlatinib (PF-6463922) is an orally available, ATP-competitive inhibitor of the receptor tyrosine kinases, anaplastic lymphoma kinase (ALK) and C-ros oncogeneFórmula:C21H19FN6O2Pureza:99.77% - 99.95%Forma y color:SolidPeso molecular:406.41Ref: TM-T3061
1mg34,00€2mg42,00€5mg60,00€10mg89,00€25mg137,00€50mg212,00€100mg374,00€1mL*10mM (DMSO)66,00€Crizotinib
CAS:Crizotinib (PF-02341066) is an ATP-competitive small-molecule tyrosine kinases inhibitor of c-MET (IC50: 8 nM) and ALK (IC50: 20 nM) receptor.Fórmula:C21H22Cl2FN5OPureza:99% - 99.87%Forma y color:SolidPeso molecular:450.34Ref: TM-T1661
2mgA consultar5mg33,00€10mg49,00€25mg55,00€50mg64,00€100mg88,00€500mg147,00€1mL*10mM (DMSO)50,00€R-268712
CAS:R-268712 is a potent ALK5 inhibitor with a 2.5 nM IC50, also targeting TGF-β type I receptor orally.Fórmula:C20H18FN5OPureza:99.61%Forma y color:SolidPeso molecular:363.39Ref: TM-T16708
1mg44,00€5mg93,00€10mg130,00€25mg250,00€50mg378,00€100mg537,00€200mg762,00€1mL*10mM (DMSO)92,00€ALK-IN-1
CAS:ALK-IN-1 is a potent ALK inhibitor, demonstrating the ability to overcome Crizotinib resistance mediated by an L1196M mutation.Fórmula:C26H34ClN6O2PPureza:99.74% - 99.80%Forma y color:SolidPeso molecular:529.01A 83-01
CAS:A 83-01 (ALK5 Inhibitor IV) is a selective inhibitor of TGF-β type I receptor ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7.Fórmula:C25H19N5SPureza:97% - 98.2%Forma y color:SolidPeso molecular:421.52SB-505124
CAS:SB505124 is a selective inhibitor of TGFβR for ALK4, ALK5.Fórmula:C20H21N3O2Pureza:97.19% - 99.92%Forma y color:SolidPeso molecular:335.4Ref: TM-T2462
1mg38,00€2mg50,00€5mg84,00€10mg120,00€25mg210,00€50mg354,00€100mg518,00€500mg1.099,00€1mL*10mM (DMSO)132,00€Alectinib hydrochloride
CAS:Alectinib hydrochloride (RO5424802 Hydrochloride) is a selective, and orally available inhibitor of ALK( IC50 : 1.9 nM)Fórmula:C30H35ClN4O2Pureza:99.74% - 99.96%Forma y color:SolidPeso molecular:519.08Ceritinib
CAS:Ceritinib (LDK378) is an ALK inhibitor with selective, ATP-competitive, and oral activity. Ceritinib has antitumor activity. Cost-effective and quality-assured.Fórmula:C28H36ClN5O3SPureza:98.52% - 99.77%Forma y color:SolidPeso molecular:558.14Ensartinib
CAS:Ensartinib (X-396) is a potent and orally active dual ALK/MET inhibitor for the treatment of ALK-positive non-small cell lung cancer (NSCLC).Fórmula:C26H27Cl2FN6O3Pureza:99.92%Forma y color:SolidPeso molecular:561.44K02288
CAS:K 02288 is a novel small molecule inhibitor of ALK1/2/3/6.Fórmula:C20H20N2O4Pureza:98% - 99.83%Forma y color:SolidPeso molecular:352.38AZ 12799734
CAS:AZ 12799734 is an orally active, selective and potent dual inhibitor of TGFBR1 and ALK5 with inhibitory effects on BMP and TGFβ for the study of tumours.Fórmula:C18H18N4O3SPureza:98.23%Forma y color:SolidPeso molecular:370.43SB-505124 hydrochloride
CAS:SB-505124 hydrochloride (SB505124 hydrochloride) is a TGF-β type I receptor (ALK4, ALK5, ALK7) inhibitor for the study of colorectal cancer.Fórmula:C20H22ClN3O2Pureza:98.71%Forma y color:SolidPeso molecular:371.86ALK5-IN-79
CAS:ALK5-IN-79 (compound 57), an ALK inhibitor, exhibits anticancer activity by inhibiting the TGF-β1/SMAD signaling pathway. It effectively reduces the production of extracellular matrix (ECM) and collagen deposition. Moreover, ALK5-IN-79 demonstrates satisfactory pharmacokinetic (PK) properties and favorable in vivo tolerance.Fórmula:C23H27N7OForma y color:SolidPeso molecular:417.51ALK2-IN-2
CAS:ALK2-IN-2 is a potent and selective inhibitor of activin receptor-like kinase 2 (ALK2) (IC50: 9 nM), inhibiting ALK2 700-fold more than ALK3.Fórmula:C28H27N5O2SPureza:99.86%Forma y color:SolidPeso molecular:497.61Ref: TM-T10287
1mg44,00€5mg89,00€10mg142,00€25mg216,00€50mg298,00€100mg411,00€200mg560,00€1mL*10mM (DMSO)99,00€EML4-ALK kinase inhibitor 1
CAS:Potent oral EML4-ALK inhibitor with a 1 nM IC50.
Fórmula:C31H48N8O3Pureza:99.62%Forma y color:SolidPeso molecular:580.76TRK/ALK-IN-1
TRK/ALK-IN-1: Potent dual TRK & ALK inhibitor; IC50s: 2.2nM (TRKA), 9.3nM (ALK WT), 38nM (ALK L1196M); cancer research potential.Fórmula:C31H35ClF2N8O2SForma y color:SolidPeso molecular:657.18Con B-1
CAS:ConB-1 is a potent and selective ALK inhibitor with low toxicity to normal cells .Fórmula:C38H52ClN7O6SForma y color:SolidPeso molecular:770.38RIPK2-IN-1
CAS:RIPK2-IN-1 (compound 18f) is a potent inhibitor of RIPK2 (IC50: 51 nM) and also inhibits ALK2 (IC50: 5 nM).Fórmula:C23H27N5O3SForma y color:SolidPeso molecular:453.56ALK-IN-21
CAS:ALK-IN-21 (B10) inhibits ALK WT (IC50: 4.59nM), L1196M (2.07nM), G1202R (5.95nM); curbs Karpas299, H2228 cell growth; for ALCL research.Fórmula:C35H45ClN6O6S4Forma y color:SolidPeso molecular:809.48ALK5-IN-26
CAS:ALK5-IN-26 (EX-22) is an ALK (Activin receptor-like kinase) inhibitor. ALK5-IN-26 inhibits ALK5 (IC50 ≤ 1 nM).Fórmula:C24H25FN8Forma y color:SolidPeso molecular:444.51ALK-IN-22
CAS:ALK-IN-22 suppresses ALK and mutants (IC50: 2.3-3.7 nM), hinders phosphorylation, and induces apoptosis in tumor studies.Fórmula:C24H24ClN7O2Forma y color:SolidPeso molecular:477.95OD36
CAS:OD36: Potent RIPK2 inhibitor, IC50=5.3 nM; hinders ALK2 signaling and osteogenesis, KD=37 nM; targets ALK2 ATP pocket.Fórmula:C16H15ClN4O2Pureza:99.45%Forma y color:SolidPeso molecular:330.77TGFBR1-IN-1
CAS:TGFBR1-IN-1 is an inhibitor of ALK5 (IC50 of 10-100 nM).Fórmula:C23H17N5O2SPureza:98%Forma y color:SolidPeso molecular:427.48OD36 hydrochloride
CAS:OD36 hydrochloride (OD-36 hydrochloride) is a potent RIPK2 inhibitor with an IC50 of 5.3 nM.OD36 hydrochloride is a macrocyclic inhibitor that binds efficientlyFórmula:C16H16Cl2N4O2Pureza:99.85%Forma y color:SolidPeso molecular:367.23KRCA-0713
CAS:KRCA-0713 is a ALK inhibitor.Fórmula:C26H32ClN5O3SPureza:98%Forma y color:SolidPeso molecular:530.08J-1048
CAS:J-1048, an activin receptor-like kinase 5 (ALK5) inhibitor, effectively suppresses TAA-induced liver fibrosis in mice through specific inhibition of the TGF-β/Fórmula:C23H17FN6S2Forma y color:SolidPeso molecular:460.55CJ-2360
CAS:CJ-2360 is a potent ALK inhibitor, effective on wild-type and various mutants, with IC50 values ranging from 2.2 to 8.9 nM, also targeting 468 kinases.Fórmula:C27H30FN5O2Forma y color:SolidPeso molecular:475.56ALK5-IN-30
CAS:ALK5-IN-30 (EX-07) is a potent inhibitor of ALK with inhibitory effects on ALK5 (IC50< 10 nM) and TGFβ-R1 (IC50< 10 nM).Fórmula:C24H25FN8Forma y color:SolidPeso molecular:444.51XST-14
CAS:XST-14 is a ULK1 inhibitor.XST-14 induces apoptosis and inhibits the growth of HCC cells.Fórmula:C16H21NO4Pureza:99.84% - 99.84%Forma y color:SolidPeso molecular:291.34ALK-IN-5
CAS:ALK-IN-5 is a potent, selective, and brain-penetrant inhibitor of anaplastic lymphoma kinase (ALK, IC50: 2.9 nM).Fórmula:C24H25FN6O3Pureza:98%Forma y color:SolidPeso molecular:464.49ALK2-IN-5
CAS:ALK2-IN-5, a pyrazolopyrimidine compound, serves as an inhibitor of ALK2 and FGFR, targeting disorders linked with their activity, including cancer [1].Fórmula:C24H32N8O2Forma y color:SolidPeso molecular:464.56Ficonalkib
CAS:Ficonalkib is a potent antineoplastic agent that inhibits the Anaplastic Lymphoma Kinase (ALK) tyrosine kinase receptor.Fórmula:C29H39N7O3SForma y color:SolidPeso molecular:565.73WY-135
CAS:WY-135 is a dual inhibitor of ALK and ROS1 (IC50 of 1.4 nM and 1.1 nM, respectively).Fórmula:C28H34ClN9O3SPureza:98%Forma y color:SolidPeso molecular:612.15SMU-B
CAS:SMU-B is a well-tolerated c-Met/ALK dual inhibitor.Fórmula:C26H25Cl2FN4O2Pureza:98%Forma y color:SolidPeso molecular:515.41ALK5-IN-29
CAS:ALK5-IN-29: selective ALK inhibitor, IC50 ≤ 10 nM, curbs tumor growth, aids in cancer research.Fórmula:C24H25FN8Forma y color:SolidPeso molecular:444.51MY10
CAS:MY10, a potent and orally active inhibitor of the receptor protein tyrosine phosphatase (RPTPβ/ζ), effectively reduces binge-like ethanol consumption andFórmula:C15H10F6OS2Pureza:98.64%Forma y color:SolidPeso molecular:384.36Ref: TM-T61678
1mg58,00€5mg126,00€10mg197,00€25mg394,00€50mg628,00€100mg982,00€200mg1.314,00€1mL*10mM (DMSO)167,00€Conteltinib
CAS:Conteltinib (CT-707) is an enzyme inhibitor with antitumor activity targeting FAK, ALK and Pyk2. It can be used to study lymphoma.Fórmula:C32H45N9O3SPureza:98.12% - 99.54%Forma y color:SolidPeso molecular:635.82Ref: TM-T14997
1mg70,00€5mg150,00€10mg216,00€25mg369,00€50mg517,00€100mg722,00€1mL*10mM (DMSO)205,00€JH-VIII-157-02
CAS:JH-VIII-157-02 inhibits ALK, specifically EML4-ALK variants, with IC50s of 2 nM.Fórmula:C28H27N5O2Pureza:99.58%Forma y color:SolidPeso molecular:465.55Ref: TM-T15612
1mg110,00€5mg227,00€10mg339,00€25mg530,00€50mg713,00€100mg982,00€1mL*10mM (DMSO)234,00€TP0427736 hydrochloride
CAS:TP0427736 hydrochloride is a novel and selective ALK5 inhibitor, capable of inhibiting Smad2/3 phosphorylation in A549 cells.Fórmula:C14H11ClN4S2Pureza:98.99%Forma y color:SolidPeso molecular:334.85ALK/EGFR-IN-2
CAS:ALK/EGFR-IN-2 is a potent dual inhibitor targeting ALK and EGFR, promoting apoptosis and G0/G1 cell cycle arrest in cancer cells.Fórmula:C27H34ClN7O3SForma y color:SolidPeso molecular:572.12ALK/ROS1-IN-1
CAS:ALK/ROS1-IN-1 is a potent and selective anti-crizotinib-resistant ALK/ROS1 dual inhibitor (IC50s: 0.530 μM and 0.174 μM for ROS1 and ALK enzyme).Fórmula:C30H35F3N6O3Pureza:98%Forma y color:SolidPeso molecular:584.63ALK/EGFR-IN-3
CAS:ALK/EGFR-IN-3 is a dual ALK and EGFR inhibitor that demonstrates potent anti-proliferative effects on various cancer cell lines, including H1975, PC9, and Baf3-Fórmula:C27H34ClN7O3SForma y color:SolidPeso molecular:572.12GW-6604
CAS:GW-6604 is an ALK5 inhibitor and shows clear antifibrotic effects resulting in liver function improvement.Fórmula:C19H14N4Pureza:99.6%Forma y color:SolidPeso molecular:298.34ALK/EGFR-IN-1
CAS:ALK/EGFR-IN-1 (Compound 8l) is a dual inhibitor targeting both ALK and EGFR, effectively blocking their phosphorylation.Fórmula:C27H34ClN7O3SPureza:98%Forma y color:SolidPeso molecular:572.12ALK-IN-6
CAS:ALK-IN-6 is an orally bioavailable inhibitor of anaplastic lymphoma kinase (ALK, IC50s: 71 nM, 18.72 nM, and 36.81 nM for ALK wild, ALK F1196M and ALK F1174L).Fórmula:C26H29ClD3N5O3SPureza:98%Forma y color:SolidPeso molecular:533.1UNC5293
CAS:UNC5293: potent oral MERTK inhibitor, Ki=190 pM, IC50=0.9 nM; selective vs Axl/Tyro3/Flt3; good mouse PK; used in leukemia research.Fórmula:C30H42N6O2Forma y color:SolidPeso molecular:518.69ALK-IN-27
CAS:Neladalkib (NVL-655) is an ALK inhibitor with antitumor activity for the study of non-small cell cancers.Fórmula:C23H22ClFN6OPureza:99.71%Forma y color:SolidPeso molecular:452.91KER047
CAS:ALK2-IN-4, a highly effective ALK2 inhibitor.Fórmula:C26H30FN7OPureza:98.49% - >99.99%Forma y color:SolidPeso molecular:475.56Ref: TM-T39764
1mg90,00€5mg215,00€10mg349,00€25mg713,00€50mg1.018,00€100mg1.558,00€1mL*10mM (DMSO)236,00€IN-1130
CAS:IN-1130: ALK5 inhibitor, IC50 - 5.3 nM (Smad3), 36 nM (casein), 4.3 μM (p38α MAPK).Fórmula:C25H20N6OPureza:99.79%Forma y color:SolidPeso molecular:420.47DA-0157
CAS:DA-0157 is an orally active inhibitor targeting EGFR and ALK, designed to overcome resistance mutations in non-small cell lung cancer (NSCLC). It effectively inhibits the proliferation of Ba/F3-EGFR Del19/T790M/C797S (IC50= 6.9 nM), Ba/F3-EGFR WT (IC50= 0.83 μM), Ba/F3-EML4-ALK-L1196M (IC50= 5.5 nM), and Ba/F3-EML4-ALK (IC50= 7.4 nM). Additionally, DA-0157 inhibits CYP2D6 with an IC50 of 5.26 μM and demonstrates antitumor activity in mouse models.Fórmula:C31H43BrN7O2PForma y color:SolidPeso molecular:656.597ALK ligand-Linker Conjugate 1
CAS:ALK ligand-Linker Conjugate 1 is an ALK ligand-connector conjugate used for the synthesis of PROTACALK degrader-4.Fórmula:C36H45N5O3Forma y color:SolidPeso molecular:595.77WZH-15-125
CAS:WZH-15-125 is a potent ALK inhibitor capable of overcoming resistance, particularly with complex ALK mutations. It exhibits an IC50 of 101.7 nM against the highly recalcitrant Lorlatinib-resistant G1202R/L1196M mutation. Additionally, WZH-15-125 can serve as a PROTAC target protein ligand for synthesizing PROTACWZH-17-002. This compound is applicable in non-small cell lung cancer research.Fórmula:C33H45BrN8O5SForma y color:SolidPeso molecular:745.73ALKBH5-IN-3
CAS:ALKBH5-IN-3 (Compound 20m) is a selective ALKBH5 inhibitor (IC50=21 nM), effectively stabilizes ALKBH5 in HepG2 cells and elevates m6A levels in intact cells.Fórmula:C11H7F3N2O3Pureza:98.32%Forma y color:SolidPeso molecular:272.18CDD-1115
CAS:CDD-1115 is a potent and selective BMPR2 inhibitor, with an IC50 of 1.8 nM and a Kiapp of 6.2 nM. It effectively suppresses gene expression mediated by bone morphogenetic proteins (BMPs). BMPs regulate cellular processes in various tissue types, such as the kidneys, skeletal muscle, heart, and reproductive organs, and can induce ectopic bone formation.Fórmula:C32H30N6O3Forma y color:SolidPeso molecular:546.619DDO-02267
CAS:DDO-02267 is a selective lysine-targeted covalent inhibitor of ALKBH5, with an IC50 value of 0.49 μM. It increases levels of N6-methyladenosine (m6A) and targets the ALKBH5-AXL signaling axis. DDO-02267 serves as a probe for studying the biological function of mRNA demethylases.Fórmula:C18H12N2O7SForma y color:SolidPeso molecular:400.362PF-06463922 acetate
CAS:PF-06463922 acetate: ALK/ROS1 inhibitor, brain- penetrable, active vs crizotinib-resistant mutants, in NSCLC trials.Fórmula:C23H23FN6O4Forma y color:SolidPeso molecular:466.46ALK-IN-23
ALK-IN-23 inhibits ALK (IC50: 1.6-0.71 nM), hinders cancer cell spread, forms colonies in vitro, and reduces tumors in mice with low toxicity.Fórmula:C26H29ClN8O3SForma y color:SolidPeso molecular:569.08CEP-14083
CAS:CEP-14083: potent ALK inhibitor, effective in NPM/ALK T-cell lymphoma, binds ATP site; IC50=11 nmol/L, also inhibits insulin receptor, preclinical efficacy.Fórmula:C31H30N6O2Forma y color:SolidPeso molecular:518.61TGF-βRI inhibitor 3
CAS:TGF-βRI inhibitor 3 (Compound 9ac) is a selective inhibitor of TGF-β that effectively suppresses the TGF-β signaling pathway. It exhibits IC50 values of 13 μM for c-Src kinase and 0.63 μM for ALK5 kinase.Fórmula:C21H21NO4Forma y color:SolidPeso molecular:351.396W23-1006
CAS:W23-1006 is a selective covalent ALKBH5 inhibitor. It binds to the ALKBH5 C200 residue with an IC50 value of 3.848 μM. The inhibitory activity of W23-1006 is approximately 30 times stronger than that of FTO and 8 times greater than that of ALKBH3. W23-1006 is applicable for research in triple-negative breast cancer (TNBC).Fórmula:C17H12BrN3O5Forma y color:SolidPeso molecular:418.198Zotizalkib
CAS:TPX-0131: potent, selective, CNS-ready, oral ALK inhibitor (WT IC50: 1.4nM, G1202R/L1196M IC50: 0.3nM) with robust antitumor effects.Fórmula:C21H20F3N5O3Pureza:98.7%Forma y color:SolidPeso molecular:447.41Ref: TM-T9414
1mg120,00€5mg283,00€10mg464,00€25mg929,00€50mg1.473,00€100mg1.977,00€200mg2.802,00€1mL*10mM (DMSO)319,00€AZ12601011
CAS:AZ12601011 is a TGFBR1 kinase inhibitor that inhibits the growth of breast tumors.Fórmula:C19H15N5Pureza:98.81%Forma y color:SolidPeso molecular:313.36Ref: TM-T10426
1mg99,00€5mg235,00€10mg376,00€25mg728,00€50mg1.093,00€100mg1.510,00€1mL*10mM (DMSO)259,00€
![5-phenylthieno[2,3-d]pyrimidin-4-amine](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FTM%2Fthumb-webp%2FT50042.webp&w=3840&q=75)
