DUB
Los inhibidores de las deubiquitinasas (DUB) se dirigen a las enzimas que eliminan las moléculas de ubiquitina de las proteínas, regulando así la estabilidad, localización y actividad de las proteínas dentro de la célula. Las deubiquitinasas desempeñan roles esenciales en varios procesos celulares, incluidos la regulación del ciclo celular, la reparación del ADN y las respuestas inmunitarias. La desregulación de la actividad de las DUB está vinculada al cáncer, a los trastornos neurodegenerativos y a las infecciones virales. Los inhibidores de las DUB pueden modular estos procesos, ofreciendo enfoques terapéuticos potenciales para estas condiciones. En CymitQuimica, proporcionamos inhibidores de DUB para apoyar su investigación en homeostasis de proteínas, cáncer y neurobiología.
Se han encontrado 110 productos para "DUB".
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GSK2643943A
CAS:GSK2643943A is a deubiquitylating enzyme (DUB) inhibitor, with an IC 50 of 160 nM for USP20/Ub-Rho. GSK2643943A has anti-tumor efficacy.Fórmula:C17H12FN3Pureza:97.09%Forma y color:SolidPeso molecular:277.2957USP7-IN-3
CAS:USP7-IN-3 is a potent and selective allosteric inhibitor of ubiquitin-specific protease 7 (USP7).Fórmula:C29H31F3N6O3Pureza:98%Forma y color:SolidPeso molecular:568.59USP1-IN-3
CAS:USP1-IN-3 is a selective inhibitor of USPI that inhibits USPI-UAFI (IC50<30 nM). USP1-IN-3 can be used to study cancer.Fórmula:C27H24F3N7OForma y color:SolidPeso molecular:519.52FT671
CAS:FT671 is a non-covalent, selective USP7 inhibitor, disrupts the stability of USP7 substrates including MDM2, elevates p53, induces p21, inhibits tumor growth.Fórmula:C24H23F4N7O3Pureza:99.76%Forma y color:SolidPeso molecular:533.4781LDN-91946
CAS:LDN-91946 is an effective and selective inhibitor of ubiquitin C-terminal hydrolase-L1 (UCH-L1) (Ki = 2.8 μM).Fórmula:C15H10N2O4SPureza:97.12%Forma y color:SolidPeso molecular:314.316USP30 inhibitor 18
CAS:USP30 inhibitor 18 is a selective inhibitor of USP30 (IC50 = 0.02 μM). USP30 inhibitor 18 is able to accelerate mitophagy and increase protein ubiquitination.Fórmula:C26H28FN3O4SPureza:99.85%Forma y color:SolidPeso molecular:497.582USP7-IN-1
CAS:USP7-IN-1 is a selective and reversible ubiquitin-specific protease 7 (USP7) inhibitor (IC50 = 77 μM).Fórmula:C23H24ClN3O3Pureza:99.82%Forma y color:White SolidPeso molecular:425.908Usp39 PROTAC-V1
Usp39 PROTAC-V1 is a PROTAC degrader targeting the splicing protein USP39, which primarily degrades intracellular USP39 via selective proteasomal degradation.Fórmula:C41H52ClN7O8S2Pureza:>99.99%Peso molecular:870.48USP1-IN-5
CAS:USP1-IN-5 (compound 10) is a potent inhibitor of both USP1, with an IC50 of less than 50 nM, and MDA-MB-436 cells, where it also exhibits an IC50 of less thanFórmula:C27H23F3N8OForma y color:SolidPeso molecular:532.52USP1-IN-6
CAS:USP1-IN-6 (Compound 11) functions as a potent USP1 inhibitor, exhibiting an IC50 value of less than 50 nM.Fórmula:C29H27F3N8OForma y color:SolidPeso molecular:560.57CT1113
CAS:CT1113, a potent inhibitor of both USP28 and USP25, effectively reduces MYC levels in vivo and demonstrates anti-tumor efficacy in a mouse pancreatic cancer CDXFórmula:C25H29N5O2SForma y color:SolidPeso molecular:463.6DUB-IN-7
CAS:DUB-IN-7 (compound 43), a deubiquitinating enzyme (DUB) inhibitor, has utility in researching diseases driven by aberrant JAK2 activity, including leukemia [1].Fórmula:C17H19N5OForma y color:SolidPeso molecular:309.37USP7-IN-13
CAS:USP7-IN-13 (Compound 101), a USP7 inhibitor, exhibits an IC50 range of 0.2-1 μM and is applicable in researching multiple myeloma [1].Fórmula:C24H28N4O3Forma y color:SolidPeso molecular:420.5USP7-IN-12
CAS:USP7-IN-12 (compound 1) is a potent, orally active inhibitor of Usp7, exhibiting an IC50 of 3.67 nM and demonstrating antiproliferative activity [1].Fórmula:C29H28ClFN4O2SForma y color:SolidPeso molecular:551.07IMP-1710
CAS:IMP-1710 is a selective UCH-L1 inhibitor with an IC50 value of 38 nM in a fluorescence polarization assay.[1]Cost-effective and quality-assured.Fórmula:C23H19N5OPureza:99.3%Forma y color:White SolidPeso molecular:381.4299MS5105
CAS:MS5105 is a covalent ligand for the deubiquitinating enzyme OTUB1, and it can be used to construct DUBTACs, such as MS8588.Fórmula:C15H21N3O2SPeso molecular:307.41USP7 activator 1
CAS:USP7activator 1 (compound MS-8) is an activator of USP7 that interacts with the allosteric C-terminal binding pocket of USP7.Fórmula:C22H32N4O3Forma y color:SolidPeso molecular:400.514FT3967385
FT3967385: New USP30 inhibitor boosts mitochondrial ubiquitylation via PINK1-PARKIN.Fórmula:C21H19N5O2Forma y color:SolidPeso molecular:373.41MTX115325
CAS:MTX115325 (Example 1) is a brain-penetrant USP30 inhibitor with an IC 50 of 12 nM, administered orally and exhibiting neuroprotective properties. It enhances ubiquitination (EC 50 =32 nM) of TOM20, a mitochondrial outer membrane protein and USP30 substrate, thereby promoting mitophagy. Additionally, MTX115325 prevents dopaminergic neuron loss and maintains striatal dopamine [1].Fórmula:C18H16N6O2Forma y color:SolidPeso molecular:348.36WWQ-03-012
CAS:WWQ-03-012 is a selective inhibitor of deSUMOylating isopeptidase DESI2, with an IC50 of 47.3 μM. It induces ubiquitination-proteasome degradation of JAK2-V617F without significantly affecting wild-type JAK2. This compound can disrupt the JAK2-STAT3/5 signaling pathway, inhibit cell proliferation, and induce apoptosis. When used in combination with Ruxolitinib, WWQ-03-012 demonstrates a synergistic effect, enhancing cytotoxicity against JAK2 mutant cells. It is applicable in cancer research, specifically in studying myeloproliferative neoplasms.Fórmula:C20H16N4O3SPeso molecular:392.43
