PKA
La proteína quinasa A (PKA) es una enzima clave en la cascada de señalización de los GPCR, activada por el AMP cíclico (cAMP) en respuesta a diversas señales extracelulares. La PKA regula una amplia gama de procesos celulares, incluidos el metabolismo, la expresión génica y el crecimiento celular. La desregulación de la actividad de la PKA está asociada con diversas enfermedades, como el cáncer, trastornos metabólicos y afecciones cardiovasculares. Los moduladores de PKA son herramientas valiosas en la investigación dirigida a comprender las vías de señalización de GPCR y desarrollar nuevas estrategias terapéuticas. En CymitQuimica, ofrecemos una selección de moduladores de PKA de alta calidad para apoyar su investigación en transducción de señales, regulación celular y mecanismos de enfermedades.
Se han encontrado 55 productos de "PKA"
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MR-L2
CAS:MR-L2 is a reversible and noncompetitive allosteric activator of long-isoform phosphodiesterase-4 (PDE4).Fórmula:C19H16Cl3FN4OPureza:98.09% - 98.94%Forma y color:SolidPeso molecular:441.71Ref: TM-T12103
1mg138,00€2mg197,00€5mg334,00€10mg500,00€25mg807,00€50mg1.099,00€100mg1.485,00€500mg2.962,00€1mL*10mM (DMSO)358,00€A-3 hydrochloride
CAS:A-3 hydrochloride: potent, reversible kinase antagonist; permeable; inhibits PKC, CKI, PKA, CKII, MLCK; Ki: 4.3-80 μM.
Fórmula:C12H14Cl2N2O2SPureza:99.32%Forma y color:SolidPeso molecular:321.22Bucladesine sodium
CAS:Bucladesine sodium (DC2797) is a cAMP analog with cell-permeable properties.Fórmula:C18H23N5NaO8PPureza:96.56% - 99.76%Forma y color:White PowderPeso molecular:491.37(2S,4R)-DS89002333
(2S,4R)-DS89002333 is an enantiomer of DS89002333 and functions as an orally active PRKACA inhibitor, exhibiting an IC50 of 0.3 nM.Fórmula:C22H20ClF2N3O3Peso molecular:447.11613KT5720
CAS:KT5720 is a cell-permeable, reversible, and ATP-competitive inhibitor of protein kinase A (PKA) (Ki: 60 nM).Fórmula:C32H31N3O5Pureza:98%Forma y color:SolidPeso molecular:537.61STAD 2
CAS:STAD-2 is a cell permeable akap disruptor, selectively binding to pka-rii and blocking the interaction of pka-ri with akapFórmula:C102H182N24O22Forma y color:SolidPeso molecular:2096.724Malantide TFA
Malantide TFA: synthetic dodecapeptide, PKA-specific with Km 15 μM, >90% PKI blockage, also PKC substrate, Km 16 μM.Fórmula:C74H125F3N22O23Forma y color:SolidPeso molecular:1747.91PKG inhibitor peptide
CAS:PKG inhibitor; mimics H2B phosphorylation site; Ki=86mM; blocks synthetic substrates, not histone phosphorylation; stops PKA activity on histones.Fórmula:C38H74N18O10Pureza:98%Forma y color:SolidPeso molecular:943.12PKG Substrate
CAS:PKG Substrate is selective for PKG, favors PKG Iα (Km=59µM) over PKG II (Km=305µM).Fórmula:C35H67N17O11Pureza:98%Forma y color:SolidPeso molecular:902.01PKI(5-24)
CAS:High affinity PKA inhibitor (Ki = 2.3 nM).Fórmula:C76H129N31O28Pureza:98%Forma y color:SolidPeso molecular:1925.057Gliotoxin
CAS:Gliotoxin, a mycotoxin, inhibits Wnt pathway, causing apoptosis in mutated colorectal cancer cells and blocks NF-κB by preserving IκB.Fórmula:C13H14N2O4S2Pureza:98%Forma y color:SolidPeso molecular:326.39Vasonatrin Peptide (VNP)
CAS:Vasonatrin peptide (VNP) is a chimera of atrial natriuretic peptide (ANP) and C-type natriuretic peptide (CNP) with potent venodilating and natriuretic activityFórmula:C123H198N36O36S3Pureza:98%Forma y color:SolidPeso molecular:2865.37JAK1/2/3 Inhibitor 1
CAS:JAK1/2/3 Inhibitor 1 is a potent protein kinase inhibitor.JAK1/2/3 Inhibitor 1 has antitumor activity that inhibits the growth of a variety of cancer cell linesFórmula:C6H2Cl2N2SPureza:99.99%Forma y color:SolidPeso molecular:205.06PKI (5-24),amide
CAS:PKI (5-24),amide is a 20-residue peptide, a potent PKA inhibitor with a Ki of 2.3 nM, derived from a cAMP inhibitor protein.Fórmula:C94H149N33O30Forma y color:SolidPeso molecular:2221.4Calcineurin substrate
CAS:Calcineurin Substrate is a Peptide from the regulatory RII subunit of cAMP-dependent protein kinase.Fórmula:C92H150N28O29Pureza:98%Forma y color:SolidPeso molecular:2112.35Malantide
CAS:Malantide, a synthetic dodecapeptide, boosts and measures PKA activity by undergoing PKA-induced phosphorylation.Fórmula:C72H124N22O21Pureza:98%Forma y color:SolidPeso molecular:1633.89CREBtide
CAS:CREBtide is a synthetic substrate for PKA (Km=3.9 µM), which is based on the phosphorylation sequence in d-CREB (cAMP response element binding protein).Fórmula:C73H129N29O19Pureza:98%Forma y color:SolidPeso molecular:1716.99Kemptide Phospho-Ser5
Kemptide (Phospho-Ser5) is a phosphoreceptor peptide that is a specific substrate for camp-dependent protein kinase (PKA).Fórmula:C32H62N13O12PPureza:98%Forma y color:SolidPeso molecular:851.89Fasudil
CAS:Fasudil (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK.Fórmula:C14H17N3O2SPureza:99.79% - 99.84%Forma y color:SolidPeso molecular:291.37H1-7 (histone H1 phosphorylation site), PKA Substrate
CAS:H1-7 (histone H1 phosphorylation site), a synthetic polypeptide serving as a PKA substrate, demonstrates utility in PKA substrate applications [1] [2].Fórmula:C31H58N14O9Forma y color:SolidPeso molecular:770.88
