Señalización PI3K / Akt / mTOR
Los inhibidores de la señalización PI3K/Akt/mTOR son compuestos que se dirigen a las vías de la fosfoinositida 3-cinasa (PI3K), la cinasa Akt y el blanco de la rapamicina en mamíferos (mTOR). Estas vías son reguladores críticos del crecimiento celular, la supervivencia, el metabolismo y la autofagia, lo que las convierte en objetivos clave en la investigación del cáncer y los trastornos metabólicos. Inhibir estas vías puede ayudar a controlar el crecimiento y la proliferación tumoral, ofreciendo potenciales estrategias terapéuticas para varios tipos de cáncer y otras enfermedades caracterizadas por una señalización celular desregulada. En CymitQuimica, ofrecemos una amplia selección de inhibidores de alta calidad de PI3K/Akt/mTOR para apoyar su investigación en oncología, señalización celular y enfermedades metabólicas.
Subcategorías de "Señalización PI3K / Akt / mTOR"
- AMPK(166 productos)
- ATM / ATR(72 productos)
- ADN-PK(49 productos)
- EGFR(591 productos)
- MELK(7 productos)
- PDK(9 productos)
- PI3K(236 productos)
- Quinasa S6(8 productos)
- gsk-3(111 productos)
- mTOR(159 productos)
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Se han encontrado 1025 productos de "Señalización PI3K / Akt / mTOR"
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EGFR Protein, Rhesus macaque, Recombinant (His)
EGFR Protein, Rhesus macaque, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag.Forma y color:Lyophilized PowderPeso molecular:69.8 kDa (predicted). Due to glycosylation, the protein migrates to 85-100 kDa based on Tris-Bis PAGE result.Cbz-B3A
CAS:Cbz-B3A is a potent inhibitor of mTORC1 signalling, inhibits phosphorylation of eIF4E-binding protein 1 (4EBP1) and blocks translation by 68%.Fórmula:C35H58N6O9Pureza:98.59%Forma y color:SolidPeso molecular:706.87EGFR Protein, Human, Recombinant (His & Avi)
<p>EGFR Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag.</p>Forma y color:Lyophilized PowderPeso molecular:71.5 kDa (predicted). Due to glycosylation, the protein migrates to 85-110 kDa based on Tris-Bis PAGE result.EGFRVIII Protein, Human, Recombinant (His & Avi), FITC-Labeled
The epidermal growth factor receptor (EGFR) is overexpressed in a variety of human epithelial tumors, often as a consequence of gene amplification.Forma y color:Lyophilized PowderPeso molecular:41.6 kDa (predicted). Due to glycosylation, the protein migrates to 68-80 kDa based on Tris-Bis PAGE result.EGFR vIII Protein, Human, Recombinant (His)
<p>EGFR vIII Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag.</p>Forma y color:Lyophilized PowderPeso molecular:61-75 Kda (reducing condition)EGFR vIII Protein, Human, Recombinant (His & Avi), Biotinylated
EGFR vIII Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-6xHis-Avi tag.Forma y color:Lyophilized PowderPeso molecular:60-90 KDa (reducing condition)EGFR Protein, Human, Recombinant (His & Avi), Biotinylated
EGFR Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag.Forma y color:Lyophilized PowderPeso molecular:71.5 kDa (predicted). Due to glycosylation, the protein migrates to 90-120 kDa based on Tris-Bis PAGE result.EGFR Protein, Human, Recombinant (His & Avi), FITC-Labeled
EGFR Protein, Human, Recombinant (His & Avi), FITC-Labeled is expressed in HEK293 mammalian cells with C-His-Avi tag.Forma y color:Lyophilized PowderPeso molecular:71.5 kDa (predicted). Due to glycosylation, the protein migrates to 90-115 kDa based on Tris-Bis PAGE result.BI-4142
CAS:<p>BI-4142 is a HER2 inhibitor that inhibits cancer cell proliferation, suppresses her2-dependent cell lines and inhibits downstream signalling.</p>Fórmula:C28H27N9O2Pureza:97.21% - 98.09%Forma y color:SolidPeso molecular:521.57Kinetin triphosphate tetrasodium
<p>Kinetin triphosphate tetrasodium is salt form of Kinetin triphosphate KTP, an ATP analog that enhances activity of Parkinson's disease-associated mutant PINK1.</p>Fórmula:C15H16N5Na4O14P3Pureza:96.80%Forma y color:SoildPeso molecular:675.19(3S,4S)-PF-06459988
CAS:(3S, 4S)-PF-06459988, a less active S enantiomer, specifically inhibits T790M mutant EGFR with high selectivity.Fórmula:C19H22ClN7O3Forma y color:SolidPeso molecular:431.88AV-412 free base
CAS:AV-412 free base is an EGFR inhibitor (IC50s: 0.75, 0.79, 0.5, 2.3, 19 nM for EGFR, EGFR(T790M), EGFR(L858R), EGFR(L858R/T790M) and ErbB2).Fórmula:C27H28ClFN6OForma y color:SolidPeso molecular:507Brivanib
CAS:<p>Brivanib (BMS-540215) is an ATP-competitive inhibitor against VEGFR2 with IC50 of 25 nM, moderate potency against VEGFR-1 and FGFR-1, but >240-fold against</p>Fórmula:C19H19FN4O3Pureza:98.87%Forma y color:SolidPeso molecular:370.38PDK1-IN-RS2
CAS:PDK1-IN-RS2, a PIFtide mimic, selectively inhibits PDK1, blocking S6K1 activation (Kd: 9 μM).Fórmula:C15H9ClN2O2S3Pureza:98%Forma y color:SolidPeso molecular:380.89PI3K-IN-30
CAS:<p>PI3K-IN-30 (compound 6d) 是一种 PI3K 的有效抑制剂，能够作用于 PI3Kα (IC50: 5.1 nM)、PI3Kβ (IC50: 136 nM)、PI3Kγ (IC50: 30.7 nM) 和 PI3Kδ (IC50: 8.9 nM)。</p>Fórmula:C20H25F2N7O3Forma y color:SolidPeso molecular:449.45Osimertinib dimesylate
CAS:Osimertinib dimesylate is an irreversible and mutant selective EGFR inhibitor (IC50s: 12 and 1 nM against EGFR L858R and EGFR L858R/T790M).Fórmula:C30H41N7O8S2Pureza:98%Forma y color:SolidPeso molecular:691.82Mavelertinib
CAS:Mavelertinib (PF-06747775) is an EGFR tyrosine kinase (EGFR TKI) inhibitor that inhibits T790M/L858R and can be used to study tumours.Fórmula:C18H22FN9O2Pureza:99.89%Forma y color:SolidPeso molecular:415.42Rilematovir
CAS:<p>Rilematovir (JNJ-678) inhibits fusion protein, has antiviral properties, low toxicity, and targets RSV treatment.</p>Fórmula:C21H20ClF3N4O3SPureza:99.82%Forma y color:SolidPeso molecular:500.92Neratinib maleate
CAS:Neratinib maleate is a selective HER2/EGFR inhibitor (IC50: 59/92 nM) used in breast and prostate cancer studies.Fórmula:C34H33ClN6O7Pureza:99.99%Forma y color:SolidPeso molecular:673.11Rociletinib hydrobromide
CAS:Rociletinib hydrobromide is an orally delivered inhibitor of the mutant form of EGFR kinase (Kis: 21.5 nM and 303.3 nM for EGFR L858R/T790M and EGFR WT).Fórmula:C27H29BrF3N7O3Pureza:98%Forma y color:SolidPeso molecular:636.46Ceftriaxone Sodium
CAS:<p>Ceftriaxone Sodium is a sporotaxin antibiotic that inhibits GSK3β and Aurora B. It is used in the study of sepsis and infective endocarditis.</p>Fórmula:C18H17N8NaO7S3Forma y color:SolidPeso molecular:576.562Tyrphostin 8
CAS:<p>Tyrphostin 8(4-Hydroxybenzylidenemalononitrile) is a potent GTPase inhibitor that inhibits EGFR kinase with an IC50 of 560 μM.Tyrphostin 8 inhibits protein</p>Fórmula:C10H6N2OPureza:99.86%Forma y color:SolidPeso molecular:170.17Anti-EGFR Monoclonal Antibody-Biotin
Antibody Type: Rabbit Monoclonal<br> Application: FCM<br> Reactivity: HumanPureza:> 95% as determined by SDS-PAGE.Forma y color:LiquidPeso molecular:150 kDaAnti-EGFR Monoclonal Antibody
Antibody Type: Rabbit Monoclonal<br> Application: FCM<br> Reactivity: HumanPureza:> 95% as determined by SDS-PAGE.Forma y color:LiquidPeso molecular:150 kDaβ-Hydroxyisovalerylshikonin
CAS:<p>Beta-Hydroxyisovalerylshikonin is an inhibitor of protein-tyrosine kinases such as v-Src and EGFR, and has been shown to induce apoptosis in several human tumor</p>Fórmula:C21H24O7Pureza:98.16%Forma y color:SolidPeso molecular:388.41Daphnetin
CAS:<p>Daphnetin (7,8-Dihydroxycoumarin), a natural coumarin derivative, is a protein kinase inhibitor with inhibitory for EGFR (IC50: 7.67 μM), PKA (IC50: 9.33 μM),</p>Fórmula:C9H6O4Pureza:97.47% - 99.8%Forma y color:SolidPeso molecular:178.14Seletalisib
CAS:Seletalisib (UCB5857) (UCB5857) is a potent and specific PI3Kδ inhibitor (IC50: 12 nM).Fórmula:C23H14ClF3N6OPureza:99.81%Forma y color:SolidPeso molecular:482.85GDC0084
CAS:<p>GDC0084 (RG7666) is a PI3K inhibitor with potential antineoplastic activity.</p>Fórmula:C18H22N8O2Pureza:99.72% - 99.87%Forma y color:SolidPeso molecular:382.42GSK2334470
CAS:<p>GSK2334470 is a novel PDK1 inhibitor (IC50: ~10 nM, in a cell-free assay), with no inhibitory at other close related AGC-kinases.</p>Fórmula:C25H34N8OPureza:99.57% - 99.87%Forma y color:SolidPeso molecular:462.59Avitinib maleate
CAS:Avitinib maleate is a pyrrolopyrimidine-based irreversible epidermal growth factor receptor (EGFR) inhibitor.Fórmula:C30H30FN7O6Pureza:98% - 99.74%Forma y color:SolidPeso molecular:603.61CH5132799
CAS:CH5132799 has been used in trials studying the treatment of Solid Tumors.Fórmula:C15H19N7O3SPureza:99.41% - 99.87%Forma y color:SolidPeso molecular:377.42PIK-294
CAS:PIK-294 is a excellently specific p110δ inhibitor(IC50=10 nM).Fórmula:C28H23N7O2Pureza:97.22% - >99.99%Forma y color:SolidPeso molecular:489.53Compound 401
CAS:Compound 401 (2-morpholino-4H-pyrimido[2,1-a]isoquinolin-4-one) is a synthetic DNA-PK inhibitor (IC50 = 0.28 μM) that also targets mTOR but not PI3K.Fórmula:C16H15N3O2Pureza:99.73% - 99.78%Forma y color:SolidPeso molecular:281.31Osimertinib
CAS:Osimertinib (AZD-9291) is a small molecule tyrosine kinase receptor inhibitor and antineoplastic agent that is used in the therapy of selected forms of NSCLC.Fórmula:C28H33N7O2Pureza:99.32% - >99.99%Forma y color:SolidPeso molecular:499.61Tyrphostin A1
CAS:Tyrphostin A1 (Tyrphostin 1) is an inhibitor of EGFR tyrosine kinase .Fórmula:C11H8N2OPureza:98.32%Forma y color:SolidPeso molecular:184.19CHIR-99021
CAS:View and buy CHIR-99021 from TargetMol.CHIR-99021 is a GSK-3α/β inhibitor.Cited in 10 publications.Fórmula:C22H18Cl2N8Pureza:97.94% - ≥95%Forma y color:SolidPeso molecular:465.34AS-604850
CAS:AS-604850: ATP-competitive PI3Kγ inhibitor, IC50 250 nM, 18x > PI3Kα, 80x > PI3Kδ/β.Fórmula:C11H5F2NO4SPureza:99.65%Forma y color:SolidPeso molecular:285.22PIK-75 hydrochloride
CAS:PIK-75 hydrochloride (PIK-75 HCl) is a p110α inhibitor, isoform-specific mutants at Ser773, and potently inhibits DNA-PK with IC50 of 2 nM in cell-free assay.Fórmula:C16H14BrN5O4S·HClPureza:97.82%Forma y color:SolidPeso molecular:488.74TX1-85-1
CAS:TX1-85-1: irreversible Her3 inhibitor (IC50: 23 nM), degrades Her3 protein, disrupts signaling, binds Cys721 covalently.Fórmula:C32H36N8O3Pureza:97.16% - 98.12%Forma y color:SolidPeso molecular:580.68AZD-8835
CAS:AZD-8835 is a mixed inhibitor of PI3Kα/δ (IC50: 6.2/5.7 nM), also with selectivity against PI3Kβ/γ (IC50: 431/90 nM).Fórmula:C22H31N9O3Pureza:98.22% - 99.88%Forma y color:SolidPeso molecular:469.54Tyrphostin B44, (+) enantiomer
CAS:Tyrphostin B44, (+) enantiomer is an inhibitor of epidermal growth factor receptor (EGFR) kinase with IC50 of 0.86 μM and has less active than the (-)Fórmula:C18H16N2O3Pureza:97.18%Forma y color:SolidPeso molecular:308.33Sulforaphene
CAS:Sulforaphene, from radish seeds, aids cancer cell apoptosis and inhibits migration; has an ED50 for velvetleaf at ~2x10^-4 M.Fórmula:C6H9NOS2Pureza:97.55% - 99.67%Forma y color:Slightly Yellowish LiquidPeso molecular:175.27KU-0063794
CAS:<p>KU-0063794 is a potent and highly specific dual-mTOR inhibitor of mTORC1 and mTORC2.</p>Fórmula:C25H31N5O4Pureza:98.21% - >99.99%Forma y color:SolidPeso molecular:465.54TGX-221
CAS:<p>TGX-221, an effective, specific, and cell membrane permeable inhibitor of the PI3K p110β catalytic subunit, is utilized for cancer treatment.</p>Fórmula:C21H24N4O2Pureza:99.68% - >99.99%Forma y color:SolidPeso molecular:364.44Lazertinib
CAS:Lazertinib (GNS-1480) is a potent, selective, irreversible EGFR-TKI; IC50: 1.7-76 nM for various EGFR mutations.Fórmula:C30H34N8O3Pureza:98.7% - 99.90%Forma y color:SolidPeso molecular:554.64Trastuzumab
CAS:Trastuzumab is a humanized monoclonal antibody for patients with invasive breast cancers that overexpress HER2.Pureza:97.1% (SDS-PAGE); 99.2% (SEC-HPLC) - SDS-PAGE: 97.1%；SEC-HPLC: 99.2%Forma y color:LiquidPeso molecular:Approximately 145.53 kDaGNE-317
CAS:GNE-317, a PI3K/mTOR inhibitor, can pass through the blood-brain barrier (BBB).Fórmula:C19H22N6O3SPureza:98.42% - 99.54%Forma y color:SolidPeso molecular:414.48AZD2858
CAS:AZD2858 is a selective GSK-3 inhibitor, inhibiting tau phosphorylation at the S396 site and activating Wnt signaling pathway.Fórmula:C21H23N7O3SPureza:98% - 99.25%Forma y color:SolidPeso molecular:453.52NRC-2694
CAS:NRC-2694 is an antagonist of the epidermal growth factor receptor (EGFR). It has anti-cancer and anti-proliferative properties.Fórmula:C24H26N4O3Pureza:99.90%Forma y color:SolidPeso molecular:418.49Autogramin-1
CAS:<p>Autogramin-1 potently inhibits starvation-induced autophagy with IC50 of 0.17 μM.</p>Fórmula:C23H27N5O5SPureza:97.69% - 99.25%Forma y color:SolidPeso molecular:485.56AG-1557 hydrochloride (189290-58-2(free base))
AG-1557 hydrochloride is an inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase (pIC50: 8.194).Fórmula:C16H15ClIN3O2Pureza:98.64%Forma y color:SolidPeso molecular:443.66AEE788
CAS:<p>AEE788 (NVP-AEE 788) has been used in trials studying the treatment of Cancer, Glioblastoma Multiforme, and Brain and Central Nervous System Tumors.</p>Fórmula:C27H32N6Pureza:98% - >99.99%Forma y color:SolidPeso molecular:440.58MAZ51
CAS:MAZ51 is a VEGFR-3 (Flt-4) tyrosine kinase inhibitor.Fórmula:C21H18N2OPureza:98.53%Forma y color:SolidPeso molecular:314.38EAI045
CAS:EAI045, an allosteric inhibitor, targets towards drug-resistant EGFR mutants but avoids the wild-type receptor.Fórmula:C19H14FN3O3SPureza:98.00% - 99.12%Forma y color:SolidPeso molecular:383.4IM-12
CAS:<p>IM-12, an effective GSK-3β inhibitor(IC50=53 nM), regulates Wnt signalling.</p>Fórmula:C22H20FN3O2Pureza:99.42% - >99.99%Forma y color:SolidPeso molecular:377.41AR-A014418
CAS:<p>AR-A014418 (GSK 3β inhibitor VIII) is an ATP-competitive, and selective GSK3β inhibitor.</p>Fórmula:C12H12N4O4SPureza:>99.99% - ≥95%Forma y color:SolidPeso molecular:308.31BI-4020
CAS:<p>BI-4020 is a fourth-generation, orally active, and non-covalent inhibitor of EGFR tyrosine kinase.</p>Fórmula:C30H38N8O2Pureza:97.21% - >99.99%Forma y color:SolidPeso molecular:542.68GS87
CAS:GS87 is a highly specific inhibitor of GSK3 (glycogen synthase kinase 3) that induces extensive differentiation of AML cells.Fórmula:C16H11N5O2SPureza:98.86%Forma y color:SolidPeso molecular:337.36Voxtalisib
CAS:Voxtalisib (XL765) (SAR245409, XL765) is a dual inhibitor of mTOR/PI3K, mostly for p110γ with IC50 of 9 nM; also inhibits DNA-PK and mTOR. Phase 1/2.Fórmula:C13H14N6OPureza:98.21% - 99.69%Forma y color:SolidPeso molecular:270.29Mutant EGFR inhibitor
CAS:<p>Selective, potent inhibitor for mutated EGFR: L858R, Exon19 deletion, T790M resistance mutants.</p>Fórmula:C27H30ClN7O2Pureza:98% - 99.75%Forma y color:SolidPeso molecular:520.03(S)-Sunvozertinib
CAS:(S)-Sunvozertinib (DZD9008) is a rationally designed selective, irreversible EGFR/HER2 inhibitor.Fórmula:C29H35ClFN7O3Pureza:99.64%Forma y color:SolidPeso molecular:584.08Tuxobertinib
CAS:<p>Tuxobertinib (BDTX-189) is a potent and selective inhibitor of allosteric EGFR and HER2 oncogenic mutations. BDTX-189 exhibits anticancer activity.</p>Fórmula:C29H29ClN6O4Pureza:99.22%Forma y color:SolidPeso molecular:561.03PKI-166 hydrochloride
CAS:EGFR-kinase inhibitor, IC50 0.7 nM, >3000x selective, cuts metastasis and angiogenesis in mice, antihypertensive, oral use.Fórmula:C20H19ClN4OForma y color:SolidPeso molecular:366.85WS6
CAS:WS6, a β cell proliferation inducer, regulates Erb3 binding protein-1 (EBP1) and the IκB kinase pathway.Fórmula:C29H31F3N6O3Pureza:97.65% - 99.95%Forma y color:SolidPeso molecular:568.59Olafertinib
CAS:Olafertinib (RX-518) is a novel mutant-selective, irreversible, orally available EGFR inhibitor. It can overcome T790M-mediated resistance in NSCLC.Fórmula:C29H28F2N6O2Pureza:98.62% - 99.706%Forma y color:SolidPeso molecular:530.57SB 216763
CAS:SB 216763 (SB216763) is an effective and specific GSK-3α/β inhibitor (IC50: 34.3 nM).Fórmula:C19H12Cl2N2O2Pureza:98.9% - 99.13%Forma y color:SolidPeso molecular:371.22Selective PI3Kδ Inhibitor 1
CAS:<p>Selective PI3Kδ Inhibitor 1 is a PI3Kδ Inhibitor( IC50 = 0.9 nM).</p>Fórmula:C23H20FN7OPureza:97.96%Forma y color:SolidPeso molecular:429.45Butein
CAS:Butein is a cAMP-specific PDE inhibitor, protein tyrosine kinase inhibitor, and SIRT1 activator.Cost-effective and quality-assured.Fórmula:C15H12O5Pureza:98.76% - >99.99%Forma y color:SolidPeso molecular:272.25TAS0728
CAS:TAS0728 is a HER2 inhibitor, with antitumor activityFórmula:C26H32N8O3Pureza:97.78%Forma y color:SolidPeso molecular:504.58YKL-06-061
CAS:<p>YKL-06-061 is a selective salt-inducible kinase (SIK) inhibitor with IC50 values of 6.56 nM/1.77 nM/20.5 nM for SIK1/2/3, respectively.</p>Fórmula:C30H37N7O2Pureza:99.52% - 99.79%Forma y color:SolidPeso molecular:527.66JCN037
CAS:JCN037 is potent, non-covalent and brain-penetrant inhibitor of EGFR(EGFR, p-wtEGFR and pEGFRvⅢ with IC50 of 2.49 nM, 3.95 nM, 4.48 nM , respectively).Fórmula:C16H11BrFN3O2Pureza:99.5%Forma y color:SolidPeso molecular:376.18WZ4003
CAS:<p>WZ4003, a highly selective NUAK kinase inhibitor, is with IC50 of 20 nM and 100 nM for NUAK1 and NUAK2, respectively.</p>Fórmula:C25H29ClN6O3Pureza:99.65% - >99.99%Forma y color:SolidPeso molecular:496.99SU5214
CAS:SU5214 is a modulator of tyrosine kinase signal transduction.Fórmula:C16H13NO2Pureza:99.45% - 99.55%Forma y color:SolidPeso molecular:251.28GSK-3β inhibitor 10
CAS:GSK-3β inhibitor 10 has skin-whitening, anti-oxidizing and PPAR activities.Fórmula:C12H12N2O3SPureza:98.06%Forma y color:SolidPeso molecular:264.3CL-387785
CAS:CL-387785 is an irreversible EGFR inhibitor with IC50 of 370 pM; overcomes T790M mutation resistance.Fórmula:C18H13BrN4OPureza:99.56% - 99.62%Forma y color:SolidPeso molecular:381.23WS3
CAS:WS3, a β cell proliferation inducer, regulates Erb3 binding protein-1 (EBP1) and the IκB kinase pathway.Fórmula:C28H30F3N7O3Pureza:97.93% - 99.94%Forma y color:SolidPeso molecular:569.58MOMIPP
CAS:<p>MOMIPP: PIKfyve inhibitor, spurs macropinocytosis, crosses blood-brain barrier, curbs glioblastoma growth.</p>Fórmula:C18H16N2O2Pureza:99.66%Forma y color:SolidPeso molecular:292.33PIK-108
CAS:PIK-108 is an allosteric inhibitor of phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunits β and δ (PI3Kβ/δ).Fórmula:C22H24N2O3Pureza:98.92%Forma y color:SolidPeso molecular:364.44YKL-05-099
CAS:<p>YKL-05-099 is a salt-inducible kinase (SIK) inhibitor. It can inhibit the activity of SIK1 and SIK3.Cost-effective and quality-assured.</p>Fórmula:C32H34ClN7O3Pureza:99.57% - 99.66%Forma y color:SolidPeso molecular:600.11NV-5138 hydrochloride
NV-5138 hydrochloride: a leucine analog, oral brain mTORC1 activator via Sestrin2, for antidepressant research.Fórmula:C7H14ClF2NO2Forma y color:SolidPeso molecular:217.64KY19382
CAS:KY19382, a dual CXXC5-DVL and GSK3β inhibitor (IC50s: 19/10 nM), boosts Wnt/β-catenin signaling and may help in metabolic disease research.Fórmula:C17H11Cl2N3O2Pureza:98.06%Forma y color:SolidPeso molecular:360.19Bisindolylmaleimide I
CAS:<p>Bisindolylmaleimide I (GF109203X) is a potent and highly selective protein kinase C (PKC) inhibitor with a Ki of 14 nM.</p>Fórmula:C25H24N4O2Pureza:98.19% - 98.75%Forma y color:Orange SolidPeso molecular:412.48Alflutinib
CAS:<p>Alflutinib (ASK120067) is an inhibitor of EGFR, and its targets including EGFR activating mutations and T790M, thus leading to tumor growth inhibition.</p>Fórmula:C28H31F3N8O2Pureza:99.87%Forma y color:SolidPeso molecular:568.59Olmutinib hydrochloride
CAS:Olmutinib is a third-gen EGFR inhibitor for T790M-positive lung cancer, blocking phosphorylation and tumor pathways. Approved in Korea (2016).Fórmula:C26H28Cl2N6O2SForma y color:SolidPeso molecular:559.51RG13022
CAS:<p>RG13022 (Tyrphostin RG13022) is a tyrosine kinase inhibitor; inhibits the autophosphorylation reaction of the EGF receptor (IC50: 4 μM).</p>Fórmula:C16H14N2O2Pureza:98.38%Forma y color:SolidPeso molecular:266.29UCB9608
CAS:UCB9608 is a selective and orally active PI4KIIIβ inhibitor (IC50: 11 nM), selective over PI3KC2 α, β, and γ lipid kinases.Fórmula:C20H26N8O2Pureza:97.53% - 99.59%Forma y color:SolidPeso molecular:410.47NU 7026
CAS:NU 7026 (DNA-PK Inhibitor II) is an effective DNA-PK inhibitor (IC50: 0.23 μM, in cell-free assays), 60-fold selective for DNA-PK than PI3K and no inhibitionFórmula:C17H15NO3Pureza:99.51% - >99.99%Forma y color:SolidPeso molecular:281.31NRC-2694 hydrochloride
CAS:NRC-2694 hydrochloride is an epidermal growth factor receptor (EGFR) antagonist potentially for the treatment of solid tumors.Fórmula:C24H27ClN4O3Forma y color:SolidPeso molecular:454.95ZSTK474
CAS:<p>PI3K Inhibitor ZSTK474 is an orally available, s-triazine derivative, ATP-competitive phosphatidylinositol 3-kinase (PI3K) inhibitor with potential</p>Fórmula:C19H21F2N7O2Pureza:98.29% - 99.95%Forma y color:White PowderPeso molecular:417.41FIIN-3
CAS:FIIN-3 is an irreversible inhibitor of FGFR.Fórmula:C34H36Cl2N8O4Pureza:97.63% - 98.92%Forma y color:SolidPeso molecular:691.61iMDK
CAS:iMDK quarterhydrate, a PI3K inhibitor, blocks MDK growth factor and enhances NSCLC treatment with MEK inhibitors, sparing normal cells.Fórmula:C21H13FN2O2SPureza:99.99%Forma y color:SolidPeso molecular:376.4Chrysophanol
CAS:<p>Chrysophanol (Turkey Rhubarb) is an EGFR/mTOR pathway inhibitor, which can be found in rhubarb, and sorrel.</p>Fórmula:C15H10O4Pureza:99.44% - 99.91%Forma y color:Physical Description Golden Yellow Plates Or Brown Powder Melting Point 196°CPeso molecular:254.24CC-115 hydrochloride
CAS:CC-115 hydrochloride: potent DNA-PK/mTOR inhibitor; IC50s: 13 nM and 21 nM; blocks mTORC1/C2 pathways.Fórmula:C16H17ClN8OForma y color:SolidPeso molecular:372.82PF-6274484
CAS:PF-6274484 is an EGFR inhibitor with Ki values of 0.14 and 0.18 nM for EGFR-L858R/T790M and WT-EGFR, respectively.Fórmula:C18H14ClFN4O2Pureza:97.71%Forma y color:SolidPeso molecular:372.78TDZD-8
CAS:<p>TDZD-8 (NP 01139) is an inhibitor of GSK-3β, with an IC50 of 2 μM; minimal inhibitory effect observed on CDK1, casein kinase II, PKA and PKC.</p>Fórmula:C10H10N2O2SPureza:97.13% - 99.61%Forma y color:White SolidPeso molecular:222.26Leniolisib
CAS:<p>Leniolisib (CDZ173) (CDZ173) is a potent and selective PI3Kδ inhibitor (IC50: 11 nM).</p>Fórmula:C21H25F3N6O2Pureza:99.88%Forma y color:SolidPeso molecular:450.46KenPaullone
CAS:KenPaullone (9-Bromopaullone), a potent CDK1, CDK2 and CDK5 inhibitor, as new enhancer for iTreg cell differentiation.Fórmula:C16H11BrN2OPureza:97.14% - 98.99%Forma y color:Tan SolidPeso molecular:327.18SB 415286
CAS:SB 415286 is a potent GSK3α inhibitor with IC50/Ki of 78 nM/31 nM with equally effective inhibition of GSK-3β.Fórmula:C16H10ClN3O5Pureza:99.55%Forma y color:SolidPeso molecular:359.72ZD-4190
CAS:<p>ZD-4190 blocks VEGFR2 and EGFR, aiding cancer treatment.</p>Fórmula:C19H16BrFN6O2Pureza:99.12%Forma y color:SolidPeso molecular:459.27NIH-12848
CAS:<p>NIH-12848 is a putative inhibitor of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) with an IC50 of 1 μM.</p>Fórmula:C20H14F3N3SPureza:99.84% - 99.9%Forma y color:SolidPeso molecular:385.41
