Señalización PI3K / Akt / mTOR
Los inhibidores de la señalización PI3K/Akt/mTOR son compuestos que se dirigen a las vías de la fosfoinositida 3-cinasa (PI3K), la cinasa Akt y el blanco de la rapamicina en mamíferos (mTOR). Estas vías son reguladores críticos del crecimiento celular, la supervivencia, el metabolismo y la autofagia, lo que las convierte en objetivos clave en la investigación del cáncer y los trastornos metabólicos. Inhibir estas vías puede ayudar a controlar el crecimiento y la proliferación tumoral, ofreciendo potenciales estrategias terapéuticas para varios tipos de cáncer y otras enfermedades caracterizadas por una señalización celular desregulada. En CymitQuimica, ofrecemos una amplia selección de inhibidores de alta calidad de PI3K/Akt/mTOR para apoyar su investigación en oncología, señalización celular y enfermedades metabólicas.
Subcategorías de "Señalización PI3K / Akt / mTOR"
- AMPK(168 productos)
- ATM / ATR(72 productos)
- ADN-PK(49 productos)
- EGFR(595 productos)
- MELK(7 productos)
- PDK(9 productos)
- PI3K(236 productos)
- Quinasa S6(8 productos)
- gsk-3(110 productos)
- mTOR(162 productos)
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Se han encontrado 1026 productos de "Señalización PI3K / Akt / mTOR"
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EGA
CAS:EGA blocks the entry of a variety of other acid-dependent bacterial toxins and viruses into mammalian cells and can be used to treat infectious diseases.Fórmula:C16H16BrN3OPureza:98% - 99.6%Forma y color:SolidPeso molecular:346.22DS21360717
CAS:DS21360717 is an effective oral tyrosine kinase inhibitor with anticancer activity and IC50 of 0.49 nM.Fórmula:C21H23N7OPureza:98%Forma y color:SolidPeso molecular:389.45WR23
CAS:<p>WR23 is a piperidinylquinoxaline derivative and a phosphoinositide 3-kinase α (PI3Kα) inhibitor.</p>Fórmula:C19H18BrN3O3SPureza:98%Forma y color:SolidPeso molecular:448.33LTURM-36
CAS:LTURM-36 is a novel inhibitor of PI 3-kinase delta.Fórmula:C22H18N2O3Pureza:98%Forma y color:SolidPeso molecular:358.39Limertinib
CAS:<p>Limertinib (ASK120067) is a EGFR tyrosine kinase inhibitor targeting EGFR T790M, applicable for the study of non-small cell lung cancer.</p>Fórmula:C29H32ClN7O2Pureza:97.44%Forma y color:SolidPeso molecular:546.06MTX-531
CAS:MTX-531 is a selective inhibitor of EGFR and PI3K with IC50 of 14.7 nM and 1.1-233 nM (PI3Kα, PI3Kβ...), respectively. It also acts as a weak agonist of PPARγ, with an EC50 of 3.4 μM in 293H cells.Fórmula:C22H20ClN5O2SForma y color:SoildPeso molecular:453.94Dihydronarwedine
CAS:Dihydronarwedine is a metabolite of Galanthamine, an inhibitor of glycogen synthase kinase 3β (GSK3β)Fórmula:C17H21NO3Forma y color:SolidPeso molecular:287.35Z118332870
CAS:Z118332870 is a potent inhibitor of EGFR and BRD4.Fórmula:C18H18FN3O3Forma y color:SolidPeso molecular:343.35PF-6422899
CAS:PF-6422899 irreversibly inhibits EGFR kinase activity by binding covalently to active-site cysteine residues in the ATP binding pocket of EGFR.Fórmula:C20H14ClFN4O2Forma y color:SolidPeso molecular:396.8MJ04
CAS:MJ04 is a selective inhibitor of Janus Kinase 3 (JAK3) with an IC50 of 2.03 nM. It hinders T cell differentiation and suppresses pro-inflammatory cytokines in macrophages induced by Lipopolysaccharides. In mice, MJ04 exhibits favorable pharmacokinetic properties and promotes hair growth in a DHT-induced alopecia model in athymic mice, without notable toxicity (LD50>2 g/kg).Fórmula:C20H16FN5Forma y color:SolidPeso molecular:345.37EphB1-IN-1
CAS:EphB1-IN-1 is a potent inhibitor of EphB1, exhibiting IC50 values of 3.0 nM for EphB1 G703C, 15 nM for EphB1 T697G, and 220 nM for EphB1 WT.Fórmula:C16H12Cl2N4O2Forma y color:SolidPeso molecular:363.2QNN33358
CAS:QNN33358 is an alkylacylglycerol acts as a protein kinase C (PKC) inhibitor and diacylglycerol (DAG) antagonist.Fórmula:C21H42O4Forma y color:SolidPeso molecular:358.56WJD008
CAS:WJD008 inhibits PI3K/mTOR, blocks cancer cell growth, and has tumor-fighting properties.Fórmula:C19H21N5O2Forma y color:SolidPeso molecular:351.4BPIQ-II (hydrochloride)
CAS:BPIQ-II, a selective EGFR inhibitor with an IC50 of 8 pM, targets ATP sites and halts EGF signals inside cells.Fórmula:C15H11BrClN5Forma y color:SolidPeso molecular:376.64PF-06672131
CAS:PF-06672131 is a selective EGFR kinase inhibitor.Fórmula:C23H21ClFN5O2Forma y color:SolidPeso molecular:453.9TWS-119
CAS:TWS-119 blocks GSK-3β, prompting neuronal formation in mouse stem cells.Fórmula:C22H16F6N4O6Forma y color:SolidPeso molecular:546.38EGFR/HER2-IN-12
CAS:EGFR/HER2-IN-12 (compound 14b) serves as a dual inhibitor targeting EGFR and HER2, demonstrating 81% and 51% inhibition respectively at a concentration of 10 μM. This compound exhibits minimal toxicity towards A431 and MDA-MB-361 cancer cells [1].Fórmula:C25H17ClN4O3SPeso molecular:488.95SPH5030
CAS:SPH5030 is an irreversible, selective inhibitor of HER2.Fórmula:C31H31FN8O3Forma y color:SolidPeso molecular:582.63EAI001
CAS:EAI001 is a potent and selective mutant epidermal growth factor receptor (EGFR) variant inhibitor that inhibits EGFRL858R/T790M with an IC50 value of 24 nM.Fórmula:C19H15N3O2SPureza:99.94%Forma y color:SolidPeso molecular:349.41AP1867
CAS:AP1867 (FK506-binding protein) is a synthetic FKBP12 F36V-directed ligand coupled to THOX derivatives, facilitating targeted protein interactions and intracellular modulation studies.Fórmula:C38H47NO11Pureza:99.86%Forma y color:SolidPeso molecular:693.78
