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Señalización PI3K / Akt / mTOR

Señalización PI3K / Akt / mTOR

Los inhibidores de la señalización PI3K/Akt/mTOR son compuestos que se dirigen a las vías de la fosfoinositida 3-cinasa (PI3K), la cinasa Akt y el blanco de la rapamicina en mamíferos (mTOR). Estas vías son reguladores críticos del crecimiento celular, la supervivencia, el metabolismo y la autofagia, lo que las convierte en objetivos clave en la investigación del cáncer y los trastornos metabólicos. Inhibir estas vías puede ayudar a controlar el crecimiento y la proliferación tumoral, ofreciendo potenciales estrategias terapéuticas para varios tipos de cáncer y otras enfermedades caracterizadas por una señalización celular desregulada. En CymitQuimica, ofrecemos una amplia selección de inhibidores de alta calidad de PI3K/Akt/mTOR para apoyar su investigación en oncología, señalización celular y enfermedades metabólicas.

Subcategorías de "Señalización PI3K / Akt / mTOR"

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Se han encontrado 1038 productos de "Señalización PI3K / Akt / mTOR"

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  • EGFR-IN-63
    Targetmol
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    EGFR-IN-63

    CAS:
    <p>EGFR- IN-63 is an EGFR inhibitor with an IC50 value of 0.096 μM. EGFR- IN-63 exhibited anticancer effects on MCF-7 cells (IC50: 2.49 μM).</p>
    Fórmula:C20H12BrN5S
    Forma y color:Solid
    Peso molecular:434.31

    Ref: TM-T62446

  • PI3Kδ-IN-3
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    PI3Kδ-IN-3

    CAS:
    <p>PI3Kδ-IN-3 (TC KHNS 11) is a PI3Kδ inhibitor with an IC50 value of 9 nM.PI3Kδ-IN-3 has a favorable pharmacokinetic profile and inhibits B cell function.</p>
    Fórmula:C28H24N6O3
    Pureza:98.43%
    Forma y color:Solid
    Peso molecular:492.53

    Ref: TM-T26252

  • EMI48
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    EMI48

    CAS:
    <p>EMI48, a derivative of EMI1, exhibits increased efficacy against mutant EGFR compared to EMI1. It specifically inhibits EGFR triple mutants [1].</p>
    Fórmula:C21H20N2O3
    Forma y color:Solid
    Peso molecular:348.4

    Ref: TM-T61179

  • OXA-01
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    OXA-01

    CAS:
    <p>OXA-01 is a potent mTORC1 and mTORC2 inhibitor, with IC 50 values of 29 nM and 7 nM, respectively [1]. OXA-01 demonstrates broad anti-tumor activity.</p>
    Fórmula:C21H20ClN5O2
    Forma y color:Solid
    Peso molecular:409.87

    Ref: TM-T21816

  • BRD1652
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    BRD1652

    CAS:
    <p>BRD1652 is a highly selective and potent GSK3 inhibitor.</p>
    Fórmula:C20H20F3N3O
    Pureza:98%
    Forma y color:Solid
    Peso molecular:375.39

    Ref: TM-T26896

  • CC260
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    CC260

    CAS:
    <p>CC260 selectively inhibits PI5P4Kα/β (Ki: 40/30 nM), with minimal effect on Plk1/RSK2, useful for metabolic, diabetes, and cancer studies.</p>
    Fórmula:C24H29Cl2N5O2
    Forma y color:Solid
    Peso molecular:490.43

    Ref: TM-T35874

  • AS2541019
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    AS2541019

    CAS:
    <p>AS2541019 is a selective Phosphatidylinositol-3-kinase p110δ (PI3Kδ) inhibitor.</p>
    Fórmula:C26H33F2N7O3
    Forma y color:Solid
    Peso molecular:529.58

    Ref: TM-T69912

  • CHMFL-PI4K-127
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    CHMFL-PI4K-127

    CAS:
    <p>CHMFL-PI4K-127 (15g) selectively inhibits PfPI4K (IC50=0.9 nM), potent against Plasmodium 3D7 (EC50=25.1 nM), with oral anti-malaria activity.</p>
    Fórmula:C18H15ClN4O3S
    Forma y color:Solid
    Peso molecular:402.85

    Ref: TM-T61971

  • EGFR-IN-54
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    EGFR-IN-54

    CAS:
    <p>EGFR-IN-54 (Compound 3c) is a potent inhibitor of EGFR (IC50: 1.623 μM) and is toxic to cancer cells.</p>
    Fórmula:C17H14N4O4S3
    Forma y color:Solid
    Peso molecular:434.51

    Ref: TM-T62457

  • EGFR-IN-25
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    EGFR-IN-25

    CAS:
    <p>EGFR-IN-25, an efficacious EGFR inhibitor, demonstrates IC50 values of 9 nM for BaF3 cells (EGFR DEL19/T790M/C797S) and 60 nM for A431 cells (WT), respectively.</p>
    Fórmula:C34H43N9O2
    Forma y color:Solid
    Peso molecular:609.76

    Ref: TM-T73101

  • EMI56
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    EMI56

    CAS:
    <p>EMI56, a derivative of EMI1, exhibits enhanced potency against mutant EGFR compared to EMI1. Additionally, EMI56 effectively inhibits EGFR triple mutants[1].</p>
    Fórmula:C21H20N2O3
    Forma y color:Solid
    Peso molecular:348.4

    Ref: TM-T35913

  • EGFR-IN-39
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    EGFR-IN-39

    CAS:
    <p>EGFR-IN-39, an acrylamide, is a potent EGFR inhibitor and antitumor agent targeting NSCLC with low toxicity. See WO2021185348A1 for details.</p>
    Fórmula:C24H25ClN6O3
    Forma y color:Solid
    Peso molecular:480.95

    Ref: TM-T63178

  • JBJ-09-063 hydrochloride
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    JBJ-09-063 hydrochloride

    <p>JBJ-09-063 hydrochloride: targeted EGFR inhibitor, effective for various mutations and TKI-resistant lung cancer models.</p>
    Fórmula:C31H30ClFN4O3S
    Forma y color:Solid
    Peso molecular:593.11

    Ref: TM-T72237

  • EGFR/HER2-IN-2
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    EGFR/HER2-IN-2

    CAS:
    <p>EGFR/HER2-IN-2 (Compound ZINC35560729) is a dual EGFR and HER2 inhibitor that acts on both EGFR (IC50: 5.02 μM) and HER2 (IC50: 0.83 μM).</p>
    Fórmula:C26H23N5O3
    Forma y color:Solid
    Peso molecular:453.49

    Ref: TM-T62776

  • SIC-19
    Targetmol
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    SIC-19

    CAS:
    <p>SIC-19, a SIK2 inhibitor, functions by promoting the degradation of SIK2 protein via the ubiquitination pathway. It inhibits the growth of cancer cells and sensitizes cells, ovarian cancer organoids, and xenograft models to PARP inhibitors (such as Olaparib).</p>
    Fórmula:C29H26N4O5S2
    Forma y color:Solid
    Peso molecular:574.67

    Ref: TM-T88487

  • EGFR-IN-21
    Targetmol
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    EGFR-IN-21

    CAS:
    <p>EGFR-IN-21, a potent EGFR inhibitor, exhibits an IC50 of 0.38 nM, demonstrating significant antitumor activity.</p>
    Fórmula:C36H44BrN10O2P
    Forma y color:Solid
    Peso molecular:759.68

    Ref: TM-T73103

  • PI3Ka-IN-5
    Targetmol
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    PI3Ka-IN-5

    CAS:
    <p>PI3Ka-IN-5 is a potent PI3Kα/mTOR inhibitor, with an IC 50 of 0.7 nM and 3.3 nM, respectively. PI3Ka-IN-5 can be used for the research of colorectal cancer .</p>
    Fórmula:C30H35N9O5
    Forma y color:Solid
    Peso molecular:601.66

    Ref: TM-T73110

  • EGFR mutant-IN-2
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    EGFR mutant-IN-2

    CAS:
    <p>EGFR mutant-IN-2 (Compound D51) is an inhibitor of EGFR mutants, specifically targeting EGFR L858R/T790M/C797S and EGFR del19/T790M/C797S mutants with IC50 values of 14 nM and 62 nM, respectively. This compound exhibits favorable pharmacokinetic (PK) parameters, safety properties, in vivo stability, and demonstrates antitumor activity [1].</p>
    Fórmula:C27H27F3N6O2S
    Forma y color:Solid
    Peso molecular:556.6

    Ref: TM-T86344

  • ON 146040
    Targetmol
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    ON 146040

    CAS:
    <p>ON 146040 is an effective inhibitor of PI3K isoforms with IC50s of 14 and 20 nM for PI3Kα and PI3Kδ, respectively.</p>
    Fórmula:C24H23N7O3S
    Pureza:97.39%
    Forma y color:Solid
    Peso molecular:489.55

    Ref: TM-T12310

  • P-2281
    Targetmol
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    P-2281

    CAS:
    <p>P-2281 is an mTOR inhibitor with anticancer and anti-inflammatory properties.P-2281 inhibits dextran sulfate sodium (DSS)-induced colitis by suppressing T-cell</p>
    Fórmula:C9H8ClN3O
    Pureza:99.95%
    Forma y color:Solid
    Peso molecular:209.63

    Ref: TM-T28285