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Señalización PI3K / Akt / mTOR

Señalización PI3K / Akt / mTOR

Los inhibidores de la señalización PI3K/Akt/mTOR son compuestos que se dirigen a las vías de la fosfoinositida 3-cinasa (PI3K), la cinasa Akt y el blanco de la rapamicina en mamíferos (mTOR). Estas vías son reguladores críticos del crecimiento celular, la supervivencia, el metabolismo y la autofagia, lo que las convierte en objetivos clave en la investigación del cáncer y los trastornos metabólicos. Inhibir estas vías puede ayudar a controlar el crecimiento y la proliferación tumoral, ofreciendo potenciales estrategias terapéuticas para varios tipos de cáncer y otras enfermedades caracterizadas por una señalización celular desregulada. En CymitQuimica, ofrecemos una amplia selección de inhibidores de alta calidad de PI3K/Akt/mTOR para apoyar su investigación en oncología, señalización celular y enfermedades metabólicas.

Subcategorías de "Señalización PI3K / Akt / mTOR"

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Se han encontrado 1038 productos de "Señalización PI3K / Akt / mTOR"

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  • PI3K/mTOR Inhibitor-13
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    PI3K/mTOR Inhibitor-13

    CAS:
    <p>PI3K/mTOR Inhibitor-13, an oral dual blocker of PI3K and mTOR, may treat sexual diseases, solid tumors, and IPF.</p>
    Fórmula:C20H13F2N5O3S
    Forma y color:Solid
    Peso molecular:441.41

    Ref: TM-T72380

  • PI3Kα/mTOR-IN-1
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    PI3Kα/mTOR-IN-1

    CAS:
    <p>PI3Kα/mTOR-IN-1 is a potent dual inhibitor of PI3Kα/mTOR.</p>
    Fórmula:C16H18N6O
    Pureza:99.89%
    Forma y color:Solid
    Peso molecular:310.35

    Ref: TM-T12589

  • EGFR-IN-2
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    EGFR-IN-2

    CAS:
    <p>EGFR-IN-2 is a oral and mutation-selective EGFR inhibito,NSCLC, with high selectivity for resistant single and double mutant T790M.</p>
    Fórmula:C26H33N9O3S
    Pureza:98.52% - 99.79%
    Forma y color:Solid
    Peso molecular:551.66

    Ref: TM-T11159

  • Mutated EGFR-IN-2
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    Mutated EGFR-IN-2

    CAS:
    <p>Mutated EGFR-IN-2 is an inhibitor of mutant-selective EGFR.</p>
    Fórmula:C29H35FN8O3
    Pureza:98%
    Forma y color:Solid
    Peso molecular:562.64

    Ref: TM-T12130

  • PI3K/mTOR Inhibitor-8
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    PI3K/mTOR Inhibitor-8

    CAS:
    <p>PI3K/mTOR Inhibitor-8: Dual PI3Kα (IC50: 0.46 nM) &amp; mTOR (IC50: 12 nM) inhibitor; blocks G1/S phase &amp; induces apoptosis in HCT-116 cells.</p>
    Fórmula:C23H22N8O4S
    Forma y color:Solid
    Peso molecular:506.54

    Ref: TM-T63470

  • PI3K-IN-38
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    PI3K-IN-38

    CAS:
    <p>PI3K-IN-38: oral PI3K inhibitor, IC50 of 0.541 µM, anticancer, anti-inflammatory, halts tumors in vivo.</p>
    Fórmula:C20H24N6O2
    Pureza:99.89%
    Forma y color:Solid
    Peso molecular:380.44

    Ref: TM-T61618

  • AMPK activator 4
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    AMPK activator 4

    CAS:
    <p>Potent, selective AMPK activator 4 enhances glucose tolerance and insulin sensitivity without affecting mitochondrial complex I.</p>
    Fórmula:C24H21ClN2O3
    Pureza:99.46% - 99.65%
    Forma y color:Solid
    Peso molecular:420.89

    Ref: TM-T62238

  • Tyrphostin AG 112
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    Tyrphostin AG 112

    CAS:
    <p>Tyrphostin AG 112 is an inhibitor of EGFR phosphorylation.</p>
    Fórmula:C13H8N4O
    Pureza:97.01%
    Forma y color:Solid
    Peso molecular:236.23

    Ref: TM-T8534

  • PI3K-IN-9
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    PI3K-IN-9

    CAS:
    <p>PI3K-IN-9 is a potent and selective inhibitor of PI3Kδ(IC50 of 8.9 nM).</p>
    Fórmula:C19H23N7O
    Pureza:98%
    Forma y color:Solid
    Peso molecular:365.43

    Ref: TM-T12458

  • EGFR-IN-53
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    EGFR-IN-53

    CAS:
    <p>EGFR-IN-53 (Compound 7) is a potent inhibitor of EGFR (IC50 = 8.264 μM) that exhibits cytotoxic activity against cancer cell lines [1].</p>
    Fórmula:C14H13N3O2S
    Forma y color:Solid
    Peso molecular:287.34

    Ref: TM-T60574

  • PI3K-IN-10
    Targetmol
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    PI3K-IN-10

    CAS:
    <p>PI3K-IN-10 is a potent inhibitor of pan-PI3K .</p>
    Fórmula:C23H19ClN6O
    Pureza:98%
    Forma y color:Solid
    Peso molecular:430.89

    Ref: TM-T12456

  • PI3Kγ inhibitor 1
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    PI3Kγ inhibitor 1

    CAS:
    <p>PI3Kγ inhibitor 1 is a inhibitor of PI3Kδ and PI3Kγ.</p>
    Fórmula:C32H26N8O2S
    Pureza:98%
    Forma y color:Solid
    Peso molecular:586.67

    Ref: TM-T12464

  • EGFR/C797S-IN-1
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    EGFR/C797S-IN-1

    CAS:
    <p>EGFR/C797S-IN-1: Potent EGFR-C797S inhibitor, IC50 of 0.128 µM, dose-dependent p-EGFR suppression, anti-tumor properties.</p>
    Fórmula:C28H30N4O3
    Forma y color:Solid
    Peso molecular:470.56

    Ref: TM-T72788

  • PI3-Kinase α Inhibitor 2
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    PI3-Kinase α Inhibitor 2

    CAS:
    <p>Phosphatidylinositol 3-kinase (PI3K) catalyzes the phosphorylation of the 3' hydroxyl position of PIs to produce the second messengers PtdIns-(3,4)-P2 and</p>
    Fórmula:C16H15N3O2S
    Forma y color:Solid
    Peso molecular:313.37

    Ref: TM-T35525

  • EGFR-IN-5
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    EGFR-IN-5

    CAS:
    <p>EGFR-IN-5 inhibits EGFR &amp; mutants; IC50: EGFR 10.4nM, L858R 1.1nM, L858R/T790M 34nM, L858R/T790M/C797S 7.2nM.</p>
    Fórmula:C31H38FN9O
    Pureza:98.17%
    Forma y color:Solid
    Peso molecular:571.69

    Ref: TM-T11160

  • PI3Kδ/γ-IN-1
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    PI3Kδ/γ-IN-1

    CAS:
    <p>PI3Kδ/γ-IN-1 is a selective and effective inhibitor of PI3Kδ/γ that can be used in the treatment of hematologic malignancies.</p>
    Fórmula:C25H28N6O4S
    Forma y color:Solid
    Peso molecular:508.59

    Ref: TM-T63497

  • PP30
    Targetmol
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    PP30

    CAS:
    <p>PP30 is an inhibitor of mTORC1 and mTORC2. It is selective within the PI3K family, inhibiting other PI3Ks only at high concentrations.</p>
    Fórmula:C18H19N7OS
    Pureza:98%
    Forma y color:Solid
    Peso molecular:381.45

    Ref: TM-T28439

  • PI3K/mTOR Inhibitor-3
    Targetmol
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    PI3K/mTOR Inhibitor-3

    CAS:
    <p>PI3K/mTOR Inhibitor-3, a potent dual-action anti-cancer imidazoline, targets PI3K and mTOR.</p>
    Fórmula:C22H23N5O
    Forma y color:Solid
    Peso molecular:373.45

    Ref: TM-T61516

  • DIF-3
    Targetmol
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    DIF-3

    CAS:
    <p>DIF-3 activates GSK-3β, degrades cyclin D1/c-Myc, and inhibits Wnt/β-catenin in DLD-1 cells, curbing HeLa cell proliferation.</p>
    Fórmula:C13H17ClO4
    Pureza:99.57%
    Forma y color:Solid
    Peso molecular:272.72

    Ref: TM-T60485

  • EHT 1610
    Targetmol
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    EHT 1610

    CAS:
    <p>EHT 1610 (EHT 5372) is a potent inhibitor of DYRK, with an IC50 of 0.36 nM and 0.59 nM for DYRK1A and DYRK1B, respectively.</p>
    Fórmula:C18H14FN5O2S
    Pureza:98.59%
    Forma y color:Solid
    Peso molecular:383.4

    Ref: TM-T15204