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Señalización PI3K / Akt / mTOR

Señalización PI3K / Akt / mTOR

Los inhibidores de la señalización PI3K/Akt/mTOR son compuestos que se dirigen a las vías de la fosfoinositida 3-cinasa (PI3K), la cinasa Akt y el blanco de la rapamicina en mamíferos (mTOR). Estas vías son reguladores críticos del crecimiento celular, la supervivencia, el metabolismo y la autofagia, lo que las convierte en objetivos clave en la investigación del cáncer y los trastornos metabólicos. Inhibir estas vías puede ayudar a controlar el crecimiento y la proliferación tumoral, ofreciendo potenciales estrategias terapéuticas para varios tipos de cáncer y otras enfermedades caracterizadas por una señalización celular desregulada. En CymitQuimica, ofrecemos una amplia selección de inhibidores de alta calidad de PI3K/Akt/mTOR para apoyar su investigación en oncología, señalización celular y enfermedades metabólicas.

Subcategorías de "Señalización PI3K / Akt / mTOR"

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Se han encontrado 1038 productos de "Señalización PI3K / Akt / mTOR"

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  • Epitinib succinate
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    Epitinib succinate

    CAS:
    <p>Epitinib succinate (HMPL-813 succinate) is an orally active and brain penetration EGFR tyrosine kinase inhibitor and can be used in studies about cancer.</p>
    Fórmula:C28H32N6O6
    Pureza:98.02% - 99.79%
    Forma y color:Solid
    Peso molecular:548.59

    Ref: TM-T35914

  • JR-AB2-011
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    JR-AB2-011

    CAS:
    <p>JR-AB2-011: selective mTORC2 inhibitor, IC50 = 0.36μM, blocks Rictor-mTOR, Ki = 0.19μM, cytotoxic in glioblastoma.</p>
    Fórmula:C17H14Cl2FN3OS
    Pureza:98.33% - 98.33%
    Forma y color:Solid
    Peso molecular:398.28

    Ref: TM-T11728

  • Falnidamol
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    Falnidamol

    CAS:
    <p>Falnidamol (BIBX 1382), an oral selective EGFR inhibitor, IC50 3 nM, weak on ErbB2 and others, anti-cancer pyrimido-pyrimidine.</p>
    Fórmula:C18H19ClFN7
    Pureza:98.816%
    Forma y color:Solid
    Peso molecular:387.84

    Ref: TM-TQ0271

  • EGFR-IN-9
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    EGFR-IN-9

    CAS:
    <p>EGFR-IN-9 is a potent EGFR kinase inhibitor with IC50s of 7 nM, 28 nM for the wild type EGFR kinase and double mutant EGFR kinase (L858R/T790M).</p>
    Fórmula:C29H24N4O3
    Pureza:99.8%
    Forma y color:Solid
    Peso molecular:476.53

    Ref: TM-T11163

  • Cloperastine fendizoate
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    Cloperastine fendizoate

    CAS:
    <p>Cloperastine fendizoate (Hustazol) inhibits the hERG K+ currents in a concentration-dependent manner (IC50: 27 nM).</p>
    Fórmula:C40H38ClNO5
    Pureza:99.97%
    Forma y color:Solid
    Peso molecular:648.19

    Ref: TM-T13619

  • GS-9901
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    GS-9901

    CAS:
    <p>GS-9901 is a selective, orally active and potent PI3Kδ inhibitor (IC50: 1 nM) for the study of non-Hodgkin's lymphoma and chronic lymphocytic leukemia.</p>
    Fórmula:C22H17ClFN9O
    Pureza:98.60% - 99.92%
    Forma y color:Solid
    Peso molecular:477.88

    Ref: TM-T15420

  • EGFR-IN-99
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    EGFR-IN-99

    CAS:
    <p>EGFR-IN-99 (JBJ-03-142-02) is an EGFR and HER2 Exon 20 insertion mutation inhibitor for the study of non-small cell lung cancer (NSCLC).</p>
    Fórmula:C25H22FN7O3
    Pureza:97.75%
    Forma y color:Solid
    Peso molecular:487.49

    Ref: TM-T35901

  • A-935142
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    A-935142

    CAS:
    <p>A-935142 enhances hERG (Kv 11.1) channels, slows inactivation, promotes activation, and shortens repolarization.</p>
    Fórmula:C18H19F3N2O2
    Pureza:98.97% - 99.91%
    Forma y color:Solid
    Peso molecular:352.35

    Ref: TM-T14077

  • EMI1
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    EMI1

    CAS:
    <p>EMI1 targets mutated EGFR in drug-resistant NSCLC research.</p>
    Fórmula:C20H18N2O3
    Pureza:99.96%
    Forma y color:Solid
    Peso molecular:334.37

    Ref: TM-T61016

  • PD 174265
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    PD 174265

    CAS:
    <p>PD 174265 is an effective, selective and reversible inhibitor of epidermal growth factor receptor (EGFR) with an IC50 of 0.45 nM.</p>
    Fórmula:C17H15BrN4O
    Pureza:99.51%
    Forma y color:Solid
    Peso molecular:371.23

    Ref: TM-T28339

  • GSK-3β inhibitor 11
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    GSK-3β inhibitor 11

    CAS:
    <p>GSK-3β inhibitor 11 (compound 21) is a potent inhibitor of glycogen synthase kinase-3β (GSK-3β) with an inhibitory concentration (IC50) of 10.02 μM.</p>
    Fórmula:C20H15N3O4S
    Pureza:97.33%
    Forma y color:Solid
    Peso molecular:393.42

    Ref: TM-T61809

  • Tyrphostin A25
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    Tyrphostin A25

    CAS:
    <p>Tyrphostin A25 (Tyrphostin AG 82) is a specific EGFR tyrosine kinase inhibitor and GPR35 agonist with an IC50 value of 0.94 μM for GPR35 and an EC50 value of 5.</p>
    Fórmula:C10H6N2O3
    Pureza:98.76%
    Forma y color:Yellow Green Powder /Off-White Solid
    Peso molecular:202.17

    Ref: TM-T21622

  • SKLB 1028
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    SKLB 1028

    CAS:
    <p>SKLB 1028, an oral EGFR/FLT3/Abl inhibitor, excels in AML and CML with Abl mutations.</p>
    Fórmula:C24H29N9
    Pureza:99.90% - >99.99%
    Forma y color:Solid
    Peso molecular:443.55

    Ref: TM-T34656

  • CGP77675
    Targetmol
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    CGP77675

    CAS:
    <p>CGP77675 (ZINC1488120) is a potent and selective inhibitor of Src family kinase with IC50s of 5-20 and 40 nM for the phosphorylation of peptide substrates and</p>
    Fórmula:C26H29N5O2
    Pureza:99.66%
    Forma y color:Solid
    Peso molecular:443.54

    Ref: TM-T30855

  • BIP-135
    Targetmol
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    BIP-135

    CAS:
    <p>BIP-135 is a potent and selective ATP-competitive GSK-3 inhibitor.</p>
    Fórmula:C21H13BrN2O3
    Pureza:99.93%
    Forma y color:Solid
    Peso molecular:421.24

    Ref: TM-T14613

  • ARN25068
    Targetmol
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    ARN25068

    CAS:
    <p>ARN25068 inhibits GSK-3β, FYN, DYRK1A kinases; acts in sub-micromolar range; combats tau hyperphosphorylation.</p>
    Fórmula:C19H18N6S
    Pureza:99.75%
    Forma y color:Solid
    Peso molecular:362.45

    Ref: TM-T61360

  • LY 456236 hydrochloride
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    LY 456236 hydrochloride

    CAS:
    <p>LY 456236 hydrochloride (MPMQ hydrochloride) is an mGlu1 receptor antagonist with an ic50 value of 143 nM.</p>
    Fórmula:C16H16ClN3O2
    Pureza:99.95%
    Forma y color:Solid
    Peso molecular:317.77

    Ref: TM-T22954

  • GSK-3 Inhibitor XIII
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    GSK-3 Inhibitor XIII

    CAS:
    <p>GSK-3 InhibitorXIII, an ATP-competitive GSK-3 inhibitor (Ki: 24 nM), can be used to study diabetes and obesity.</p>
    Fórmula:C18H15N5
    Pureza:99.85% - 99.86%
    Forma y color:Solid
    Peso molecular:301.35

    Ref: TM-T78578

  • Larotinib
    Targetmol
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    Larotinib

    CAS:
    <p>Larotinib is an orally active, potent, and broad-spectrum tyrosine kinase inhibitor (TKI) with an IC50 of 0.6 nM for EGFR.</p>
    Fórmula:C24H26ClFN4O4
    Pureza:98.45%
    Forma y color:Solid
    Peso molecular:488.94

    Ref: TM-T73334

  • AZ044
    Targetmol
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    AZ044

    CAS:
    <p>AZ044 is a potent, selective inhibitor of type III phosphatidylinositol-4-kinase alpha-subtype (PI4KIIIalpha).</p>
    Fórmula:C24H27N3O3S
    Pureza:99.5%
    Forma y color:Solid
    Peso molecular:437.55

    Ref: TM-T26698