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Señalización PI3K / Akt / mTOR

Señalización PI3K / Akt / mTOR

Los inhibidores de la señalización PI3K/Akt/mTOR son compuestos que se dirigen a las vías de la fosfoinositida 3-cinasa (PI3K), la cinasa Akt y el blanco de la rapamicina en mamíferos (mTOR). Estas vías son reguladores críticos del crecimiento celular, la supervivencia, el metabolismo y la autofagia, lo que las convierte en objetivos clave en la investigación del cáncer y los trastornos metabólicos. Inhibir estas vías puede ayudar a controlar el crecimiento y la proliferación tumoral, ofreciendo potenciales estrategias terapéuticas para varios tipos de cáncer y otras enfermedades caracterizadas por una señalización celular desregulada. En CymitQuimica, ofrecemos una amplia selección de inhibidores de alta calidad de PI3K/Akt/mTOR para apoyar su investigación en oncología, señalización celular y enfermedades metabólicas.

Subcategorías de "Señalización PI3K / Akt / mTOR"

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Se han encontrado 1038 productos de "Señalización PI3K / Akt / mTOR"

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  • YKL-06-062
    Targetmol
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    YKL-06-062

    CAS:
    <p>YKL-06-062 is a second-generation salt-inducible kinase (SIK) inhibitor that inhibits SIK1, SIK2 and SIK3 with IC50s of 2.12 nM, 1.40 nM and 2.86 nM.</p>
    Fórmula:C31H39N7O
    Pureza:99.87%
    Forma y color:Solid
    Peso molecular:525.69

    Ref: TM-T17272

  • PQR514
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    PQR514

    CAS:
    <p>PQR514: more potent pan-PI3K inhibitor than predecessor PQR309, exhibits strong anticancer activity in vitro and in OVCAR-3 model.</p>
    Fórmula:C16H20F2N8O2
    Pureza:98.77% - 99.19%
    Forma y color:Solid
    Peso molecular:394.38

    Ref: TM-T70058

  • MELK-8a hydrochloride
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    MELK-8a hydrochloride

    CAS:
    <p>MELK-8a hydrochloride is a potent inhibitor of maternal embryonic leucine zipper kinase (MELK, IC50 = 2 nM). </p>
    Fórmula:C25H33ClN6O
    Pureza:99.87%
    Forma y color:Solid
    Peso molecular:469.02

    Ref: TM-T11996

  • PKI-166
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    PKI-166

    CAS:
    <p>PKI-166: oral EGF-R tyrosine kinase inhibitor (IC50: 0.7 nM), halts growth &amp; spread of many human cancers, including pancreatic.</p>
    Fórmula:C20H18N4O
    Pureza:99.2%
    Forma y color:Solid
    Peso molecular:330.38

    Ref: TM-T16549

  • RS1-PDK1 inhibitor
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    RS1-PDK1 inhibitor

    CAS:
    <p>RS1-PDK1 inhibitor (RS 1) is a selective inhibitor of the protein kinase PDK1 that can be used to treat and prevent disease or disorders.</p>
    Fórmula:C15H9ClN2O2S3
    Pureza:98.12%
    Forma y color:Solid
    Peso molecular:380.89

    Ref: TM-T24741

  • TGX-115
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    TGX-115

    CAS:
    <p>TGX-115 inhibits PI 3-K p110β (IC50=0.13μM) &amp; p110δ (IC50=0.63μM), treats various cardiovascular diseases.</p>
    Fórmula:C20H20N2O3
    Pureza:99.48%
    Forma y color:Solid
    Peso molecular:336.38

    Ref: TM-T24873

  • Rezivertinib
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    Rezivertinib

    CAS:
    <p>Rezivertinib (BPI-7711) is an EGFR inhibitor with antitumor activity and can be used to study central nervous system diseases.</p>
    Fórmula:C27H30N6O3
    Pureza:99.26% - 99.89%
    Forma y color:Solid
    Peso molecular:486.57

    Ref: TM-T36644

  • NVP-BAG956
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    NVP-BAG956

    CAS:
    <p>NVP-BAG956 is an ATP-competitive PI3K inhibitor (IC50s: 34/56/112/444 nM for PI3Kδ/PI3Kα/PI3Kγ/PI3Kβ).</p>
    Fórmula:C28H21N5
    Pureza:99.25% - 99.80%
    Forma y color:Solid
    Peso molecular:427.5

    Ref: TM-TQ0313

  • (R)-(-)-Rolipram
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    (R)-(-)-Rolipram

    CAS:
    <p>(R)-(-)-Rolipram ((-)-Rolipram) is an R-enantiomer of Rolipram which is a PDE4 inhibitor.</p>
    Fórmula:C16H21NO3
    Pureza:99.54%
    Forma y color:Solid
    Peso molecular:275.34

    Ref: TM-T13448

  • PF-249
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    PF-249

    CAS:
    <p>PF-249 (PF-06685249) is a β1-selective AMPK with an EC50 of 12 nM for AMPK α1β1γ1 and can be used in studies about diabetic nephropathy.</p>
    Fórmula:C17H16ClN3O3
    Pureza:97.01%
    Forma y color:Solid
    Peso molecular:345.78

    Ref: TM-T24626

  • SRX3207
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    SRX3207

    CAS:
    <p>SRX3207 is an inhibitor of Syk and PI3K and relieves tumor immunosuppression.</p>
    Fórmula:C29H29N7O3S
    Pureza:99.85%
    Forma y color:Solid
    Peso molecular:555.65

    Ref: TM-T22430

  • GSK-3β inhibitor 2
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    GSK-3β inhibitor 2

    CAS:
    <p>GSK-3β inhibitor 2 (5-Thiazolecarboxamide,2-[2-[(cyclopropylcarbonyl)amino]-4-pyridinyl]-4-methoxy-) is a BBB-crossing and selective inhibitor of GSK-3β (IC50</p>
    Fórmula:C14H14N4O3S
    Pureza:99.08%
    Forma y color:Solid
    Peso molecular:318.35

    Ref: TM-T11471

  • YLF-466D
    Targetmol
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    YLF-466D

    CAS:
    <p>YLF-466D (C24) is a newly developed AMPK activator, which inhibits platelet aggregation.</p>
    Fórmula:C29H20ClNO3
    Pureza:97.74%
    Forma y color:Solid
    Peso molecular:465.93

    Ref: TM-T13368

  • Sunvozertinib
    Targetmol
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    Sunvozertinib

    CAS:
    <p>Sunvozertinib (DZD9008) is a potent ErbBs and BTK inhibitor, with inhibitory effects on EGFR, Her2.Cost-effective and quality-assured.</p>
    Fórmula:C29H35ClFN7O3
    Pureza:98.11% - 99.63%
    Forma y color:Solid
    Peso molecular:584.08

    Ref: TM-T64124

  • ABC1183
    Targetmol
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    ABC1183

    CAS:
    <p>ABC1183, an oral diaminothiazole, inhibits GSK3α/β, CDK9, hinders cancer cell growth, induces G2/M arrest, and modulates phosphorylation.</p>
    Fórmula:C18H14N4OS
    Pureza:98.92%
    Forma y color:Solid
    Peso molecular:334.39

    Ref: TM-T23601

  • (Z)-RG-13022
    Targetmol
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    (Z)-RG-13022

    CAS:
    <p>(Z)-RG-13022 is a tyrosine kinase (TK) inhibitor that preferentially inhibits the TK activity of the EGF receptor, restricting the EGF-stimulated growth of cultured cells. It demonstrates an IC50 of 11 μM for DNA synthesis in HN5 cells, showcasing thrice the potency of its isomer, (E)-RG-13022 (IC50 = 38 μM). This compound is applied in breast cancer cell research [1] [2].</p>
    Fórmula:C16H14N2O2
    Forma y color:Solid
    Peso molecular:266.29

    Ref: TM-T84525

  • PI3Kδ-IN-17
    Targetmol
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    PI3Kδ-IN-17

    CAS:
    <p>PI3Kδ-IN-17 (Compound S5) is a potent PI3K δ inhibitor, exhibiting an IC50 value of 2.82 nM and demonstrates significant efficacy in suppressing the</p>
    Fórmula:C23H24F3N7O2
    Pureza:98%
    Forma y color:Solid
    Peso molecular:487.48

    Ref: TM-T81468

  • MTI-31
    Targetmol
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    MTI-31

    CAS:
    <p>MTI-31 (LXI-15029) is a potent oral mTORC1/2 inhibitor with a Kd of 0.20 nM, &gt;5,000-fold selectivity, and an IC50 of 39 nM.</p>
    Fórmula:C26H30N6O3
    Pureza:99.97%
    Forma y color:Solid
    Peso molecular:474.55

    Ref: TM-T35343

  • PI3K/mTOR Inhibitor-14
    Targetmol
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    PI3K/mTOR Inhibitor-14

    CAS:
    <p>PI3K/mTOR Inhibitor-14 (compound Y-2) serves as a dual inhibitor of PI3K and mTOR, exhibiting IC50 values of 171.4 nM and 10.1 nM , respectively, and</p>
    Fórmula:C28H30N8O3S
    Pureza:98%
    Forma y color:Solid
    Peso molecular:558.66

    Ref: TM-T81470

  • PI3K/mTOR Inhibitor-7
    Targetmol
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    PI3K/mTOR Inhibitor-7

    CAS:
    <p>Potent PI3K/mTOR inhibitor, 4.7x stronger than gedatolisib; IC50: 1.4 μM (PI3K), 0.3 μM (mTOR); impacts PI3K/Akt/mTOR pathway; research in cancer.</p>
    Fórmula:C29H33N9O4
    Forma y color:Solid
    Peso molecular:571.63

    Ref: TM-T64041