Toxicología

<p>Applications N-Desmethyl Regorafenib (Pyridine)-N-oxide-d3 is the isotope labelled analog of N-Desmethyl Regorafenib (Pyridine)-N-oxide (D293280); a synthetic metabolite of Regorafenib (R143000) used for treatment and prevention of cancer.<br>References Wilhelm, S.: PCT Int. Appl. WO 2011130728 A1 20111020. Oct 20, 2011<br></p>

<p>Stability Very Hygroscopic<br>Applications 4-(p-Chloro-α-phenylbenzyl)-1-piperazineethanol is used in the synthesis of antifungal triazole and imidazole derivatives. Impurity of an intermediate in the formation of Cetrizine.<br>References Rezaei, Z. et al.: Archiv. Pharm., 344, 658 (2011)<br></p>

<p>Applications An antibacterial agent that is effective againts garam negative bacteria such as Pseudomonas Aeruginosa as well as some gram positive bacteria.<br>References Massano, S. et al.: Antimicrob. Agents Chemother., 8, 132 (1975); Falagas, M.E. et al.: J. Antimicrob, Chemother., 65, 1863 (2010);<br></p>

<p>Applications Labelled Clofazimine (C324300). Antibacterial (tuberculostatic, leprostatic).<br>References Doak, A., et al.: J. Med. Chem., 53, 4259 (2010), Rodgers, A., et al.: Chem. Res. Toxicol., 23, 724 (2010), Gohil, V., et al.: Nat. Biotechnol., 28, 249 (2010),<br></p>

<p>Applications Creatine-(methyl-d3) Monohydrate is an isotopic analog of Creatine Monohydrate (6020-87-7), which is a nitrogenous organic acid that occurs naturally in vertebrates. Its main role is to facilitate recycling of Adenosine Triphosphate (ATP), the energy currency of the cell, primarily in muscle and brain tissue.<br>References Barcelos, R.P., et al.: Mini Rev Med Chem., 16, 12-8 (2016)<br></p>

<p>Stability Light Sensitive<br>Applications Antibiotic substance produced by Streptomyces spp. Antiamebic; antibacterial; antirickettsial.<br>References Weiss, et al.: Antibiot. Chemother., 7, 374 (1957), Goldenthal, E.I., et al.: Toxicol. Appl. Pharmacol., 18, 185 (1971),<br></p>

<p>Applications Cyclanilide is a plant growth regulator that functions by interactting with auxin-regulated processes. Cyclanilide is commonly used on cotton plants to either suppress vegetative growth or accelerate senescence. Cyclanilide is also used as a bioregulator of deciduous fruit trees.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Burton, J. et al.: Proc. Plant Growth Reg. Soc. Am., 36, 56 (2009); Burton, J. et al.: J. Plant Growth Reg., 27, 342 (2008); Elfving, D.C. et al.: Act Horticul., 884, 159 (2010);<br></p>

<p>Applications Labelled Flupirtine (F598510). Analgesic. Substituted pyridine with central analgesic properties. A potassium channel opener<br>References Vaupel, D., et al.: Eur. J. Pharmacol., 162, 447 (1989), Nickel, B., et al.: Arzneim.-Forsch., 40, 909 (1990), Lunemann, J., et al.: J. Immunol., 168, 4881 (2002),<br></p>

<p>Applications The main cis-monohydroxylated metabolite of Praziquantel (P702095).<br>References Buehring, K., et al.: Eur. J. Drug Metab. Pharm., 3, 179 (1978), Moldeus, P., et al.: Methods Enzymol., 52, 60 (1978), Cioli, D., et al.: Pharmacol. Ther., 68, 35 (1995),<br></p>

<p>Applications Trimethoprim lactate salt is an antibacterial agent.<br>References Lees, G. et al.: Brit. J. Pharmacol., 73, 535 (1981);<br></p>

<p>Applications Labelled analogue of Sulfachlorpyridazine, an antibacterial compound.<br>References Wammer, K.: Environ. Toxicol. Chem. 25, 1480 (2006);<br></p>

<p>Applications An important inhibitory neurotransmitter. The foods contain γ-aminobutyric acid (GABA) at an amount that shows immediate effect of suppressing autonomic nerve activity related to blood pressure increase. Reacts with isothiocyanates to produce thioureas which have antifungal activity.<br>References Lowry, O., et al.: J. Biol. Chem., 193, 265 (1951), Gerlach, M., et al.: Brain Res., 741, 142 (1996), Choi, D., et al.: J Neurobiol 1992, 23, 1261<br></p>

<p>Applications Ammeline is a metabolite of Melamine (1) (M208700), which acts as a non-protein nitrogen food additive (2). Also present in pet foods as well (3).Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA). Environmental contaminants; Food contaminants.<br>References 1. Mast RW. et al.: Food Chem Toxicol. 1983 Dec;21(6):807-10.2. Ehling S. et al.: Food Addit Contam. 2007 Dec;24(12):1319-25.3. Vail T. et al.: J Anal Toxicol. 2007 Jul-Aug;31(6):304-12.<br></p>

<p>Applications Tefluthrin is a pyrethroid based insecticide. Tefluthrin is used in the control of a broad range of soil pests, including members of the Coleoptera, Lepidoptera, and Diptera.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References McDonald, E. et al.: Bright. Crop Prot. Conf. Pest Dis., 3, 1143 (1986); Jutsum, A.R. et al.: Bright. Crop Prot. Conf.<br></p>

<p>Applications Isotope labelled 2,4-Dihydroxybenzophenone is an metabolite of Benzophenone (B204980), an compound used in the manufacturing of antihistamines, hypnotics and insecticides.<br>References Li, M.H., et al.: Toxicol. Environ. Chem., 94, 566 (2012); Leon, Z.. et al.: Anal. Bioanal. Chem., 398, 831 (2010); Bechard, K., et al.: Aquat. Toxicol., 90, 310 (2008);<br></p>

<p>Applications Febantel (F227000) impurity. Anthelmintic.<br>References Wollweber, H., et al.: Arzneim.-Forsch., 34, 531 (1984),<br></p>

<p>Impurity Moxifloaxacin EP Impurity D<br>Stability Hygroscopic<br>Applications 8-Fluoro-6-methoxy Moxifloxacin Dihydrochloride (Moxifloaxacin EP Impurity D) is an impurity of Moxifloxacin (M745000).<br>References Martel, A., et al.: Drugs Fut., 22, 109 (1997), Tobin, C., et al.: J. Antimicrob. Chemother., 42, 278 (1998),<br></p>

<p>Applications Pyroxasulfone is an inhibitor of the biosynthesis of very-long-chain fatty acids. Pyroxasulfone is also used to control grass weed species in pre-emergence in major field crops.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Busi, R., et al.: Pest. Manag. Sci., 72, 1665 (2016)<br></p>

<p>Stability Hygroscopic, Light Sensitive<br>Applications A mixture of 2 labelled metabolites of Bbutadiene. The isomeric ratio has been determine to be approximately 1:1 based on proton nmr integration.<br>References Barnsley, E.A., et al.: Biochem. J., 100, 362 (1966),<br></p>

<p>Applications 2,2,2-Trichloro-acetic Acid is an acetic acid analogue used for the precipitation of macromolecules including proteins, DNA and RNA as well as for cosmetic treatments.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wiley D. et al.: Clin. Infect. Dis., 35m S210 (2002);<br></p>

<p>Applications Labelled fluorinated quinolone antibacterial.<br>References Monk, J.P., et al.: Drugs, 33, 346 (1987), Drlica, K., Curr. Opin. Microbiol. 2, 504 (1990)<br></p>

<p>Applications A reagent used in the preparation of hepatitis C virus NS3 protease inhibitors and PMPA prodrugs with antiretroviral activity.<br>References Sheng, X. et al.: Bioorg, Med. Chem. Lett., 169, 3453 (2009); Arimilli, M.N. et al.: Antiviral Chem. Chemother., 8, 557 (1997);<br></p>

<p>Applications Ethacrynic Acid is a diuretic used to treat high blood pressure and swelling caused by congestive heart failure, liver failure and kidney failure.<br>References Beyer, et al.: J. Pharmacol. Exp. Ther., 147, 1 (1965); Kim., et al.: Am. J. Cardiol., 27, 407 (1971); Williamson, H.E., et al.: J. Clin. Pharmacol., 17, 663 (1977);<br></p>

<p>Applications Clindamycin 2-Phosphate Sulfoxide is a degradation product of Clindamycin phosphate (C580005) after the stressing test.Clindamycin phosphate impurity.<br></p>

<p>Applications Ketoconazole-d3 is the labeled analogue of Ketoconazole (K186000), which inhibits cytochrome P-450 dependent steps in the biosynthesis of steroid hormones in vivo. Antimetastatic and antineoplastic activity. Orally active 5-lipoxygenase and thromboxane synthase inhibitor.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lambert, A., et al.: Biochem. Pharmacol., 35, 3999 (1986); Van Wauwe, J.P. and Janssen, P.A.J., J. Med. Chem., 32, 2231 (1989); Nardone, P.A., et al.: . Surg. Res., 44, 425 (1988); Tucker, W.F.G., et al.: Br. Med. J., 293, 882 (1986)<br></p>

<p>Applications 3,4-Dichloroaniline is used in the preparation of the herbicide propanil (P760840).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Olodaterol is a long acting β-adrenoceptor agonist used as an inhalation for treating patients with chronic obstructive pulmonary disease (COPD).<br>References Cazzola, M., et al.: Pharmacol. Rev., 64, 450 (2012); Bouyssou, T., et al.: Bioorg. Med. Chem. Lett., 20, 1410 (2010);<br></p>

<p>Applications 4-Methoxy-6-(trifluoromethyl)-1,3,5-triazin-2-amine can be used as reactant/reagent in preparation of N-phenylsulfony-N'-pyrimidinylureas as herbicides.<br>References Hamprecht, G., et al.: Ger. Offen., DE 4322726 A1 19950112 (1995)<br></p>

<p>Applications Labelled analogue of Flucloxacillin, a semisynthetic penicillin.<br>References Markovich, M. et al.: Antibiot. Med. Biotekhnol., 31, 603 (1986); Rahman, M. et al.: Biochem. Pharmacol., 46, 1721 (1993); Silva, D. et al.: Med. Biol. Res., 37, 963 (2004);<br></p>

<p>Impurity Atorvastatin EP Impurity D<br>Applications O-Methyl Atovaquone (Atorvastatin EP Impurity D) is a Atovaquone derivative that shows protozoacidal activity against Plasmodium falciparum.<br>References Danoun, S., et. al.: Heterocycl. Commun., 5, 343 (1999)<br></p>

<p>Applications N-Desmethyl Terbinafine Hydrochloride is a metabolite of Terbinafine (T107500), an orally active, antimycotic allylamine related to naftifine.<br>References Humbert, H., et al.: Pharam. Drug Dispos., 19, 417 (1998); Vickers, A., et al.: Drug Metab. Dispos., 27, 1029 (1999); Iverson, S., et al.: Chem. Res. Toxicol., 14, 175 (2001)<br></p>

<p>Applications cis-Tetrahydrophthalimide is an intermediate to synthesize cis-Captafol (C175740), which was used as a fungicide.<br>References Knight, A., et al.: Regulatory Toxicol. Pharmacol., 55, 188 (2009); Rotroff, D., et al.: J. Toxicol. Environ. Health Part B Critical Rev., 13, 329 (2010)<br></p>

<p>Applications Pemoline-d5 is a CNS stimulant. Controlled Substance.<br>References Connors, C.K., et al.: Psychopharacolgia, 26, 321 (1972), Schafer, E.W., et al.: Toxicol. Appl. Pharmacol., 21, 315 (1972),<br></p>

<p>Applications Labelled Pentylenetetrazole (P227500). Non-specific CNS stimulant; convulsant; narcotic antagonist.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Goldenthal, et al.: Toxicol. Appl. Pharmacol., 18, 185 (1971),<br></p>

<p>Applications EPN is an insecticide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Boyd-Boland, A., et al.: Analyst, 121, 929 (1996); Henderson, C., et al.: J. Econ. Entomol., 48, 157 (1955)<br></p>

<p>Impurity Abacavir API<br>Applications Abacavir (Abacavir API) is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.<br>References (1) Jackson, A., et al.: Antivir Ther. 17, 19 (2012) (2) Yuen, G. J., et al.: Clin Pharmacokinet. 47, 351 (2008)<br></p>

<p>Applications Stereoisomer to Darunavir (D193500), a second generation HIV-1-protease inhibitor; structurally similar to amprenavir. Antiviral. It is a COVID19-related research product.<br>References Koh, Y., et al.: Antimicrob. Agents Chemother., 47, 3123 (2003), Arasteh, K., et al.: AIDS, 19, 943 (2005), Surleraux, D.L.N.G., et al.: J. Med. Chem., 48, 1813 (2005),<br></p>

<p>Applications Methyl Trithion, is used as an insecticide in biological studies to determine the effect on agriculture. Also, this compound was used evaluate the repellency in deer mouse and house mouse to determine the toxicity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Burden, G.S., et al.: J. Econ. Entomol., 61, 1565 (1968); Schafer, E. W., et al.: Arch. Environ. Con. Tox., 14, 111, (1985)<br></p>

<p>Applications Guthoxon is an organophosphorus anticholinesterase pesticide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Murphy, S., et al.: Toxicol Appl Pharmacol, 12, 22 (1968); Wong, J., et al.: J. Agric. Food Chem., 55, 1117 (2007);<br></p>

<p>Stability Moisture Sensitive, Light Sensitive<br>Applications A metabolite of Ketorolac.<br>References Mroszczak, E., et al.: Drug Metab. Dispos., 15, 618 (1987), Brocks, D., et al.: Clin. Pharmacokinet., 23, 415 (1992), Vakily, M., et al.: Pharm. Res., 12, 1652 (1995), Gillis, J., et al.: Drugs, 53, 139 (1997),<br></p>

<p>Applications Labelled analogue of Chlorocholine Chloride, a plant growth regulator that is primarily used on ornamental plants.<br>References Pinto, A.C.R. et al.: Acta Horticult., 683, 399 (2005); Gu, Z. et al.: Hun. Nong. Dax. Xueb., 35, 383 (2009); Xing, S. et al.: J. Med. pLant Res., 5, 1962 (2011);<br></p>

<p>Impurity Mesalazine EP Impurity L<br>Applications The toxicity of halogenated benzoic acids was found to be directly related to the compound's hydrophobicity. Toxicity and quantitative structure-activity relationships of benzoic acids to Pseudokirchneriella subcapitata.<br>References Moore, D., et al.: Environ. Toxicol. Chem., 16, 794 (1997), Zhao, Y., et al.: Sci. Total Environ., 216, 205 (1998), Fiorentino, A., et al.: J. Agric.Food Chem., 51, 1005 (2003),<br></p>

<p>Applications Smooth muscle relaxant. Used as antispasmodic; in treatment of urinary incontinence.<br>References Setnikar, I., et al.: J. Pharmacol. Exp. Ther., 130, 356 (1960), Bradley, D.V., et al.: J. Clin. Pharmacol., 10, 65 (1970), Cova, A., et al.: Arzneim.-Forsch., 25, 1707 (1975), Gould, S., et al.: Urology, 5, 612 (1975), Ruffmann, R., et al.: Drugs Exp. Cin. Res., 13, 57 (1987),<br></p>

<p>Applications 6-(tert-Butylamino)-3-methyl-1,3,5-triazine-2,4(1H,3H)-dione is a metabolite of Terbuthylazine (T110500) a triazine herbicide.<br>References Schenck, F., et al.: Bull Environ. Contam. Toxicol., 73, 24 (2004),<br></p>

<p>Applications Fluazinam is a broad spectrum fungicide. Fluazinam is commonly used for control of Sclerotinia blight and other soilborne pathogens of peanut as well for the control of potato blight.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Smith, F.D. et al.: Peanut Sci., 19, 115 (1992); Roques, J.-F. et al.: Phytoma, 460, 48 (1994); Platt, H.W. et al.: Tests Agrochem. Cult., 15, 36 (1994);<br></p>

<p>Applications 5-Chloro-3-methyl-4-nitro-1H-pyrazole (CMNP) is a pyrazole-derived plant growth regulator used as a citrus abscission agent.<br>References Barcelo, J., et al.: J. Plant Nutr., 13, 1 (1990), Delessert, C., et al.: Plant Mol. Biol., 55, 165 (2004), Both, M., et al.: The Plant Cell, 17, 2107 (2005),<br></p>

<p>Applications Bitertanol is a foliar-applied triazole fungicide used to protect tropical and subtropical crops in agriculture, in particular bananas. Bitertanol has effects on behavior that are similar to those of psychomotor stimulants.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Allen, A.R. et al.: Neurotoxicol. Teratol., 15, 237 (1993); Scheinpflug, H. et al.: Pflanzsensch.-Nach., 34, 8 (1981);<br></p>

<p>Applications Dazomet is a as fumigant used for the control of brown root rot disease. Dazomet was shown to be a possible agent in preventing pest incursion in agriculture, gardening and agroforestry.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Fu, C.H., et al.: Pest. Mange. Sci., 68, 959 (2012); Liberatore, L., et al.: Water. Air. Soil Poll., 223, 4751 (2012); Sande, D., et al.: Int. J. Enviro. Res. Pub. Health., 8, 4649 (2011);<br></p>

<p>Stability Hygroscopic<br>Applications Antiepileptic; increases levels of GABA in the brain.<br>References Chang, Z.L., et al.: Anal. Profiles Drug Subs., 8, 529 (1979), Nau, H., et al.: Pharmacol. Toxicol., 69, 310 (1991), Loscher, W., et al.: Prog. Neurobiol., 58, 31 (1999)<br></p>

<p>Applications Nebivolol (N387896) metabolite.<br></p>

<p>Applications Propyzamide-d3 (phenyl-2,4,6-d3) (CAS# 1219805-79-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications Flurbiprofen (1S,2R,5S)-(+)-Menthyl Ester is an isomer version of Flurbiprofen rac-Menthyl Ester (M221723), a Flurbiprofen (F598700) derivative. Flurbiprofen is an anti-inflammatory used as an analgesic<br>References Chalmers, et al.: Ann. Rheum. Dis., 31, 319 (1972), Nishizawa, et al.: Thromb. Res., 3, 577 (1973)<br></p>

<p>Applications H1 Histamine receptor antagonist. Antihistaminic.<br>References Weidmann, et al.: Boll. Chim. Farm., 106, 467 (1967), Gober, B., et al.: Pharmazie, 43, 539 (1988), Breccia, A., et al.: Curr. Ther. Res., 49, 622 (1991), Schran, H., et al.: J. Clin. Pharmacol., 36, 911 (1996),<br></p>

<p>Applications Agricultural fungicide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Corrales, M., et al.: Food Chem. Toxicol., 48, 3471 (2010), Lagunas-Allue, L., et al.: Anal. Bioanal. Chem., 398, 1509 (2010), Wong, J., et al.: J. Agric. Food Chem., 58, 5897 (2010),<br></p>

<p>Applications Labelled Benzocaine (B202970). Benzocaine is used as an anesthetic (local).<br>References Ali, S.L., et al.: Anal. Profiles Drug Subs., 12, 73 (1983),<br></p>

<p>Applications Echothiophate Iodide is an anticholinesterase drug.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ashani, Y., et al.: Biochem. Pharm., 30, 2593 (1981)<br></p>

<p>Stability Hygroscopic<br>Applications Acarviosin is a part of the potent α-amylase inhibitor, Acarbose (A123500), an anti-diabetic drug used to treat type 2 diabetes mellitus (1,2,3).<br>References (1) Shibata, Y., et al.: Carbohydrate. Res., 228, 377 (1992) (2) Raimbaud, E., et al.: Carbohydrate. Res., 227, 351 (1992) (3) Geng, P., et al.: Carbohydr Res. 343, 882 (2008)<a href="https://www.ncbi.nlm.nih.gov/pubmed/18294624PMID" target="_blank" rel="noreferrer noopener">https://www.ncbi.nlm.nih.gov/pubmed/18294624PMID</a>: 18294624<br></p>

<p>Applications DL-Panthenol is used in the topical treatment of skin disorders, such as minor irritations and skin burns. Also used in the strengthening and treatment of hair.<br>References Ebner F. et al.: Am J Clin Dermatol. 3, 427 (2002); Heldermann, M. et al.: SOFW J. et al.: 40, 44 (2012);<br></p>

<p>Applications Etomidate is a hypnotic. Neuroprotective &amp; Neuroresearch Products<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Goetz, E., et al.: Anaesthesist, 23, 331 (1974), Chang, Z. L., et al.: Anal. Profiles Drug Subs., 12, 191 (1983),<br></p>

<p>Applications Mepanipyrim Phenyl-d5 is deuterium labelled Mepanipyrim (M223600).Mepanipyrim (M223600) is an anilinopyrimidine fungicide which have been used in the management of fungal diseases in strawberries.<br>References Tetada, M., et al.: Toxicol. Appl. Pharmacol., 154, 1 (1999); Hauke, K., et al.: Commun. Agri. Appl. Biol. Sci., 69, 743 (2004);<br></p>

<p>Applications 2,6-Diisopropylnaphthalene, is a building block used for the synthesis of more complex compounds. 2,6-Diisopropylnaphthalene (2,6-DIPM) is also used in the manufacturing of pesticide products intended to prevent sprouting of stored potatoes.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Beaver, R. G., et al.: American Journal of Potato Research, 80, 311 (2013);<br></p>

<p>Applications An inhibitor of proliferation and supresses gene expression in bladder smooth muscle cells.<br>References Park, J.M., et al.: J. Urol., 162, 1110 (1999), Watson, M., et al.: Brit. J. Pharmacol., 127, 590 (1999)<br></p>

<p>Applications Dialifos is an organophosphorus pesticide. It is extremely poisonous.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Isotope Labelled analogue of Erythritol, a sugar alcohol used as a food additive.<br>References Leisso, R., et al.: J. Agr. Food. Chem., 61, 1373 (2013); Hillmann, H., et al.: J. Agr. Food. Chem., 60, 9974 (2012);<br></p>

<p>Applications Phenthoate is an organothiophosphate insecticide used against lepidoptera and houseflies.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Strempel, S., et al.: Envrion. Toxicol. Chem., 32, 1187 (2013); Zhao, Q. et al.: Anal. Bioanal. Chem., 405, 4765 (2013);<br></p>

<p>Applications N6-Isopentenyladenosine has antiproliferative activity on MCF-7 breast cancer cells.<br>References Rajabi, M. et al.; DNA Cell Biol.; 29, 687 (2010)<br></p>

<p>Stability Hygroscopic<br>Applications An active carboxylate of Mevastatin (M340500). It is a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase with hypocholesterolemic activity. It has been shown to be effective in reducing cholesterol synthesis in vivo, and thereby in lowering cholesterol levels in blood.<br>References Endo, A. et al.: Atheroscler. Supp., 5, 39 (2004); Hosobuchi, M. et al.: J. Ferm. Bioeng., 76, 470 (1993);<br></p>

<p>Impurity Betamethasone Dipropionate EP Impurity J<br>Applications Betamethasone 9,11-Epoxide 17,21-Dipropionate (Betamethasone Dipropionate EP Impurity F) is an impurity of Betamethasone (B327000), an antiinflammatory agent.<br>References Shou, M., et al.: J. Pharm. Biomed. Anal., 50, 356 (2009),<br></p>

<p>Applications Betamethasone 17-Butyrate is an impurity of Clobetasone 17-Butyrate (C583550), an glucocorticoid used for anti-inflammatory purposes.<br></p>

<p>Applications A metabolite of Baclofen (c).<br>References Ault, B., et al.: Eur. J. Pharmacol., 71, 357 (1981),<br></p>

<p>Applications 19-Norandrosterone is the oxidized byproduct of Nandrolone (N315000), an anabolic steroid that is present naturally in the human body.<br>References Jiang, J.Q., et al.: J. Food. Sci., 77, 63 (2012); Delgadillo, M.A., et al.: J. Chromatograph. Anal. Technol. Biomed. Life. Sci., 897 (2012);<br></p>

<p>Applications Droxicam is a non-steroidal anti-inflammatory drug.<br>References Lapeyre-Mestre, M., et. al.: Fundam. Clin. Pharm., 20, 391 (2006)<br></p>

<p>Stability Hygroscopic<br>Applications A metabolite of Azelastine (A808250).<br>References Heinemann, U. et al.: J. Chrom. B Anal. Tech. Biomed. Life Sci., 793, 389 (2003); Tasaka, K., et al.: Arzneim.-Forsch., 29, 488 (1979);<br></p>

<p>Applications Trestolone acetate is a derivative of Trestolone (T719600), a synthetic androgen used as a potential hormonal male contraceptive method that induces a state of temporary infertility.<br>References Garcia-Becerra, R., et al.: Reproduction., 143, 211 (2012); Attardi, B.J., et al.: J. Steroid. Biochem. Molec. Biol., 122, 212 (2010)<br></p>

<p>Impurity Beclomethasone Dipropionate EP Impurity F<br>Applications 6α-Bromo Beclomethasone Dipropionate (Beclomethasone Dipropionate EP Impurity F) is an impurity of Beclomethasone Dipropionate (B131030).<br></p>

<p>Applications 2-Fluoroadenosine is a fluorinated analog of Adenoside (A280400) nucleotide.<br>References Long, X., et al.: J. Pharmacol. Exper. Ther., 335, 781 (2010); Ham, M., et al.: J. Pharmacol. Exper. Ther., 335, 607 (2010);<br></p>