Ácidos y reactivos sintéticos

<p>Applications (1,​5-​Cyclooctadiene)​(hexafluoroacetylace​tonato)​iridium(I) is a catalyst used in hydrogenation reactions in organic synthesis.<br>References Maj, A. et al.: Tetrahedron, 72, 1375 (2016);<br></p>

<p>Applications tert-Butyl (S)-2-(hydroxymethyl)pyrrolidine-1-carboxylate, is a building block used foe the synthesis of novel nicotinic acetylcholine receptor ligands with cognition-enhancing properties. It can also be used in the synthesis of chiral β-amino sulfides and β-amino thiols.<br>References Elliiot, R. L., et al.: Bioorg. Med. Chem. Lett., 6, 2283 (1996); Abreo, M. A., et al.: J. Med. Chem., 39(4), 817 (1996);<br></p>

<p>Applications Vitamin D3 (V676045) analog.<br>References Roy, A., et al.: Steroids, 60, 530 (1995);<br></p>

<p>Applications 6-[[3-[(1S)-2-Methoxy-1-methylethoxy]-5-[(1S)-1-methyl-2-phenylethoxy]benzoyl]amino]-3-pyridinecarboxylic Acid, is one of the glucokinase activator derivatives. GKAs activate GK via binding to an allosteric site of the enzyme. They increase glucose-stimulated insulin secretion and decrease blood glucose levels. Also, glucokinase activator GKA50 is shown to be able to promote proliferation by increasing the cell volume and thus, preventing apoptosis in rat pancreatic insulinoma-1 beta cell.<br>References Wei, P., et al.: Diabetologia, 52, 2142 (2009); McGlasson, L., et al.: Mol. Cell. Endo., 342, 48, (2011);<br></p>

<p>Applications 4-benzylmorpholine-2-carbonitrile (cas# 126645-52-1) is a useful research chemical.<br></p>

<p>Applications Volasertib (BI 6727) is a highly potent Polo-like kinase (PLK) inhibitor.<br>References Rudolph, D., et al.: Clin. Cancer Res., 15, 3094 (2009); Grinshtein, N., et al.: 71, 1385 (2011)<br></p>

<p>Stability Volatile<br>Applications Cyclobutanone is a member of cycloketone compounds that have potential genotoxic and cytotoxic effects and are most commonly found in irradiated food.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Anandon, A., et al.: EFSA Journal, 9, 1930 (2011); Delincee, H., et al.: Radiat. Phys. Chem., 63, 431 (2002); Obana, H. ,et al.: J. Health Sci., 52, 375 (2006)<br></p>

<p>Applications A MEK inhibitor with antitumor activity.<br>References Lee, W., et al.: Bioorg. Med. Chem. Lett., 15, 3573 (2005), Normanno, N., et al.: J. Cell. Physiology, 207, 420 (2006), Narlawar, R., et al.: J. Med. Chem., 49, 7588 (2006),<br></p>

<p>Applications Sodium tetrakis[3,5-bis(trifluoromethyl)phenyl]borate, also known as the BARF anion, is a compound used in catalytic cycles due to its inability to coordinate to metal centres.<br>References Brookhart, M.; et al.: J. Am. Chem. Soc., 114, 5894 (1992).<br></p>

<p>Applications 2-{[2-(Dimethylamino)ethyl]methylamino}ethanol is a reagent in the preparation of diamino(aminoalkoxy)quinazolines.<br>References Liu, F., et al.: J. Med. Chem., 53, 5844 (2010);<br></p>

<p>Applications KP372-1 is a specific Akt inhibitor that demonstrates at least 10-fold selectivity against a panel of additional kinase targets, including CDK1, ERK1, GSK3β, LCK, MEK1, PKA, PKC, and S6K. By blocking Akt signaling, KP372-1 has been shown to inhibit proliferation and to induce apoptosis of thyroid cancer cells.<br>References Zeng, Z., et al.: Cancer Res, 66, 3737-3746 (2006); Mandal, M., et al.: Br. J. Cancer, BJC, 92, 1899-1905 (2005)<br></p>

<p>Applications Epacadostat is a potent and novel indoleamine 2,3-dioxygenase (IDO1) inhibitor with IC50 of 10 nM. It has high selectivity over IDO2 and tryptophan 2,3-dioxygenase (TDO).<br>References Yue, Eddy W., et al.: ACS Med. Chem. Lett., 8, 486 (2017);<br></p>

<p>Applications Intermediate in the production of mutagenic pyrolyzates.<br>References Grassy, G., et al.: Eur. J. Med. Chem., 17, 109 (1982),<br></p>

<p>Applications 2-amino-3-methylpentan-1-ol (cas# 24629-25-2) is a useful research chemical.<br></p>

<p>Applications Gabexate Mesylate is a serine protease inhibitor. Gabexate Mesylate inhibits trypsin, plasmin, plasma kallikrein and thrombin. Gabexate Mesylate inhibits lipopolysaccharide-induced tumor necrosis factor-α (TNF-α) production through nuclear factor-κB and activator protein-1 activation. Neuroresearch &amp; Neuroprotective Product.<br>References Yuksel, M. et al.: J. Pharmacol. Exp. Therap., 305, 298 (2003); Tamura, Y. et al.: Biochim. Biophys. Acta, 484, 417 (1977); Ohno, H. et al.: Thromb. Res., 24, 445 (1981);<br></p>

<p>Applications N4-Benzoylcytosine is a reactant in the synthesis of 1',2'-cyclopentyl nucleosides as potential antiviral agents.<br>References Dang, Q., et. al.: Tetrahedron Lett., 55, 5092 (2014)<br></p>

<p>Applications Diethyl D-(-)-Tartrate is used as a chiral reagent in a host of chemical reactions, suhc as marin toxin and antitumor agent phorboxazole A, or asymmetric syntheses of S,S-dialkyl-substituted sulfoximines.<br>References Pandey, A. et al.: Synthesis, 23, 3827 (2011); Kuntiyong, P. et al.: Org. Biomol. Chem., 10, 7884 (2012);<br></p>

<p>Applications (S)-(-)-Propylene Carbonate is used in the synthesis of β-hydroxy sulfides.<br>References Upare, P. et al.: Green, Chem. Lett. Rev. et al.: 5, 19 (2012<br></p>

<p>Applications 2,3-Dibromopropene is used in preparation of Quaternary Ammonium Salt derivatives for use as Trimethylamine production inhibitors.Also, used in preparation of Boron containing compounds as Phosphodiesterase PDE4 inhibitors.<br>References Nudel, K., et al.:PCT Int. Appl., (2020); Strohbach, Joseph W., et al.: PCT Int. Appl., (2020);<br></p>

<p>Applications Copper oxychloride<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Ammonium Hexafluorophosphate is commonly available form of the hexafluorophosphate anion, inert and hence a suitable counterion. It is a useful synthetic intermediate. It can be used to prepare organometallic diphenols.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Powell, C., et al.: J. Am. Chem. Soc., 125, 602 (2003); Macchioni, A., et al.: Organometallics, 18, 3061 (1999)<br></p>

<p>Applications 2-Bromoacetic Acid Phenylmethyl Ester is used in the synthesis of somatostatin analogues with tumor-targeting properties . Also used in the synthesis of inhibitors of phospholipase A2, indolizine and indene derivatives.<br>References Heppeler, A. et al.: Chem. A. Eur. J., 5, 1974 (1999); Hagishita, S. et al.: J. Med. Chem., 39, 3636 (1996);<br></p>

<p>Applications BDP 37 is a AMPA modulator that may exhibit therapeutic properties for treating Alzheimer's disease, schizophrenia, and mild cognitive impairment (MCI) (1,2,3,4). It is also an ampakine drug that facilitates activation of glutamatergic AMPA receptors.<br>References (1) Arai, A., et al.: J. Pharmacol. Exp. Ther., 278, 627 (1996)(2) Marini, A., et al.: J. Biol. Chem., 273, 29394 (1998)(3) Balkowiec, A., et al.: J. Neurosci., 22, 10399 (2002) (4) Dicou, E., et al.: Brain Res., 970, 221 (2003)<br></p>

<p>Applications Dibromoacetic Acid is a halogenated disinfection byproduct. Dibromoacetic Acid was found to induce apoptotic changes and hydroxyl radical formation in human peripheral blood mononuclear cells (PBMCs). Dibromoacetic Acid also found to exhibit carcinogenic activity in which mice and rats were exposed to drinking water containing different concentrations of Dibromoacetic Acid that resulted in increased incidences of mononuclear cell leukemia, malignant mesothelioma, hepatocellular neoplasms, and hepatoblastoma.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Michalowicz, J., et al.: Toxicol. In Vitro 29, 1416 (2015); Natl Toxicol Program Tech Rep Ser. 537, 1 (2007)<br></p>

<p>Applications A useful intermediate in the synthesis of polypeptides.<br></p>

<p>Applications 2-Amino-4-methylphenylboronic acid, pinacol ester<br></p>

<p>Applications Ethynyltrimethylsilane is used in the production of novel histone deacetylase inhibitors for the treatment of Freidreich’s ataxia. It also aids in the preparation of conjugated polymers with sn anthracene backbone.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Xu, C. et al.: Pharmaceu. 4, 1578 (2011); Kobayashi, E. et al.: J. Polym. Sci. Part A: Polym. Chem., 28, 2641 (1990);<br></p>

<p>Applications (R)-1-(Benzyloxy)propan-2-ol is the R-isomer of 1-Benzyloxy-2-propanol (B287760), a compound used in the synthetic preparation of glucokinase activators for the treatment of diabetes.<br>References You, L., et al.: J. Am. Chem. Soc., 134, 7117 (2012); Henze, O., et al.: J. Am. Chem. Soc., 128, 5923 (2006); Hoff, B.H., et al.: Tetrahedron. Asym., 7, 3181 (1996); Sugawara, F., et al.: Agr. Biol. Chem., 50, 2261 (1986);<br></p>

<p>Applications 5-Iodovanillin is used in laccase catalyzed synthesis of iodinated phenolic compounds with antifungal activity. Molecular modeling studies of interaction between plasmid DNA (pBR322) and dendritic antioxidants.<br>References Ihssen, J., et al.: PLoS One, 9, e89924 (2014); Chhetri, P., et al.: J. Cancer Sci.Ther., 3, 220 (2011)<br></p>

<p>Applications (S)-(+)-α-Methoxyphenylacetic Acid (cas# 26164-26-1) is a compound useful in organic synthesis.<br></p>

<p>Applications Tetra-n-butylammonium Iodide is used in the preparation of novel quaternary amines to serve as antibacterial agents in the rise of drug-resistant bacteria. Also used in phosphonium reversible inhibitors of cholinesterases.<br>References Ingalsbe, M. et al.: Bioorg. Med. Chem. Lett., 19, 4984 (2009); Basova, N. et al.: J. Evol. Biochem. Phys., 47, 420 (2011);<br></p>

<p>Applications 1,1-Cyclopropanedicarboxylic Acid, is an inhibitor of 1-aminocyclopropane-1-carboxylic Acid oxidase in Lycopersicum esculentum (Tomato plant). It can also be used as a building block for the synthesis of a series of cyclopropanecarboxamides, having antifungal activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Petritis, K., et al.: Phytochemical Analy., 14, 347 (2003); Liu, X. H., et al.: Euro. J. Med. , 44, 2782 (2009);<br></p>

<p>Applications Ciliobrevin D is an inhibitor of the AAA+ ATPase motor cytoplasmic dynein.<br>References Firestone, A., et al.: Nature, 484, 125 (2012)<br></p>

<p>Applications 1-Chloro-3-iodopropane is used as reagent in the synthesis of several organic compounds including that of (-)-Terengganensine A which is a complex heptacyclic monoterpene indole alkaloid. Also used in the synthesis of A-366 which is a potent inhibitor of histone methyltransferase G9a.<br>References Piemontesi, C., et al.: Angew. Chem. Int. Edit., 55, 6556 (2016); Sweis, R., et al.: ACS Med. Chem. Lett., 5, 205 (2014);<br></p>

<p>Applications CPhos, is used as a catalyst in the synthetic preparation of palladium-catalyzed Negishi coupling of secondary alkylzinc halides with aryl bromides and chlorides.<br>References Han, C., et al.: J. Am. Chem. Soc., 131, 7532 (2009)<br></p>

<p>Applications Methyl 4-(Chloroformyl)butyrate is used in the synthesis of Leukotriene B4, a proinflammatory agent produced from leukocytes.<br>References Crooks, S. et al.: Int. J. Biochem. Cell. Biol., 30, 173 (1998); Wenkert, E. et al.: J. Org. Chem., 55, 6203 (1990);<br></p>

<p>Applications Cesium Acetate (cas# 3396-11-0) is a useful research chemical.<br></p>

<p>Applications ZJ 43 is a glutamate carboxypeptidase II (GCPII) and N-acetylaspartylglutamate (NAAG) inhibitor that reduces the deleterious effects of excessive extracellular glutamate.<br>References Feng, J. et al.: Brain Res., 1469, 144 (2012); Zuo, D. et al.: J. Biol. Chem., 287, 21773 (2012); Feng, J. et al.: Brain Res., 1395, 62 (2011)<br></p>

<p>Applications N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic Acid, referred to as Pemetrexed, is used in the treatment of malignant pleural mesothelioma (MPM).<br>References Pasello, G. et al.: Anticanc. Res., 32, 5393 (2012);<br></p>

<p>Applications Drug used in the treatment of Parkinson’s disease and psychosis.<br>References Snigdha, S., et al.: J. Pharmacol. Exper. Ther., 332, 622 (2010), Meltzer, H., et al.: Neuropsychopharmacol., 35, 881 (2010),<br></p>

<p>Stability Moisture Sensitive<br>Applications Bromotripyrrolidinophosphonium Hexafluorophosphate is a peptide coupling reagent that has been used in the synthesis of rostate tumor specific peptide-peptoid hybrid prodrugs.<br>References Li, S., et. al.: Chem. Commun., 47, 12840 (2011); Lee, J., et. al.: Bioorg. Med. Chem. Lett., 25, 2849 (2015)<br></p>

<p>Applications An amide analog of Eugenol, and is used therapeutically as an antispasmodic.<br>References Marrero-Ponce, Y., et al.: Bioorg. Med. Chem., 14, 6502 (2006),<br></p>

<p>Applications 4-Chlorobenzeneboronic Acid is used as a catalyst for the preparation of 4-hydroxycoumarin derivatives which display antitrypanosomal and antioxidant properties. It is also used as a catalyst for the asymmetric borane reduction of electron-deficient ketones.<br>References Perez-Cruz, F. et al.: Bioorg Med. Chem. Lett., 22, 5569 (2012); Liu, H. et al.: J. Mol. Cata. A. Chem., 244, 68 (2006);<br></p>

<p>Applications 6-Bromo-2H-1,4-benzoxazin-3(4H)-one is used in the synthesis of substituted benzoxazinones; selective 5-HT6 antagonists used for treating central nervous system diseases and gastrointestinal tract disorders.<br></p>

<p>Applications 4-Dimethylaminobenzylamine is used in the preparation of N-benzyl and N-aryl furylpurines as inhibitors of mycobacteria for potential use as antituberculosis agents.<br>References Bakkestuen, A., et al.: Bioorg. Med. Chem. Lett., 10, 1207 (2000), Gundersen, L., et al.: Med. Chem., 45, 1383 (2002),<br></p>

<p>Applications 12-CROWN-4 (cas# 294-93-9) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Pentadecanoic acid is a saturated fatty acid. Pentadecanoic acid was utilized as a biomarker to examine for the intake of milk fat in relation to its metabolic risk factors. Pentadecanoic Acid that is also produced by certain plant species and acts as an toxic essential oil, which is known to exhibits potential anxiolytic, antinociceptive and antimicrobial properties.<br>References Smedman, A.EM., et al.: Am. J. Clin. Nutr., 69, 22 (1999); Radulovic, N.S., et al.: Food. Chem. Toxiol., 50, 2016 (2012);<br></p>

<p>Applications tert-Butylethyne, is an organic building block used for the synthesis of various pharmaceutical compounds, such as Terbinafine Hydrochloride (T107500), which is a synthetic allylamine antifungal.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hadi, V., et al.: Tetrahedron Letters, 50, 2370 (2009); Petranyi, G., et al.: Science, 224, 1239 (1984);<br></p>

<p>Applications A macrolide isolated from Penicillium brefeldianum. It affects the vesticular transport of the Golgi apparatus and induces DNA fragmentation which leads to apoptosis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Misumi, Y., et al.: J. Biol. Chem., 261 (1986), Mordente, J.A., et al.: J. Urol., 159, 275 (1998), Erokhina, M.V., et al.: Membr. Cell Biol., 12, 871 (1999), Nojiri, H., et al.: FEBS Letters, 453, 140 (1999),<br></p>

<p>Applications Gefarnate is a synthetic isoprenoid that is used to treat chronic gastric and duodenic ulcers. Gerfarnate is also used for gastric ulcer prophylaxis.<br>References Barbara, L., et al.: Curr. Med. Res. Opin., 2, 399 (1974); Kobayashi, K., et al.: Toko. J. Exp. Med., 140, 181 (1983); Newman, C. &amp; Montgomery, D.: Brit. J. Clin. Pract., 27, 85 (1973); Smith, P., et al.: Scand. J. Gastroenterol., 10, 753 (1975)<br></p>

<p>Stability Moisture Sensitive<br>Applications O-Acetylsalicyloyl chloride is used in the derivatisation of amines, and also improve electrochemical detection of these amines when they are run through high-performance liquid chromatography. O-Acetylsalicyloyl chloride is also used as a reagent to synthesize benzimidazole derivatives, compounds that inhibit leukotriene synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Banoglu, E., et al.: Bioorg. Med. Chem., 20, 3728 (2012); Smith, R., et al.: J. Chromatogr. A, 455, 349 (1988)<br></p>

<p>Applications 4-Carboxymethylphenylboronic acid<br></p>

<p>Applications A Wittig reagent.<br></p>

<p>Applications (S)-5,6-Dehydro Pregabalin is derived from rac 5,6-Dehydro Pregabalin (D230055), which is an impurity of the anti-convulsant, Pregabalin (P704800).<br>References Dousa, M, et al.: J. Pharmac. Biomed. Anal., 53, 717 (2010);<br></p>

<p>Applications (2R)-2-[Bis[3,5-bis(trifluoromethyl)phenyl][(trimethylsilyl)oxy]methyl]-pyrrolidine is often used as a catalyst in organocatalytic Michael addition reactions.<br>References Veerasamy, N., et al.: J. Org. Chem., 78, 4779 (2013); Liu, R., et al.: Org. Lett., 15, 2266 (2013); Veerasamy, N., et al.: Org. Lett., 14, 1596 (2012)<br></p>

<p>Applications Trimethylamine N-Oxide Dihydrate is as an oxygen transfer agent used to promote heterometallic cluster catalyzing coordinative hydrogenation. Trimethylamine N-Oxide Dihydrate is also used as a catalyst in the preparation of thermally stable TiO2 nanorod incorporated polymers and semiconductor/metal nanocomposites.<br>References Li, Q. et al.: Fen. Cuihua, 12, 1 (1998); Patra, N. et al. Polym. Degrad. Stab., 96, 1377 (2011); Cozzoli, P.D. et al.: J. Am. Chem. Soc., 126, 3868 (2004);<br></p>

<p>Applications 5-Amino-2-methylene-1,3,3-trimethylindoline (cas# 6872-05-5) is a compound useful in organic synthesis.<br></p>

<p>Applications (S,S)-(-)-Hydrobenzoin is a chral auxiliary with versatile applications. It is also used as a building block.<br>References Marshall, J., et al.: J. Org. Chem. 60, 7230 (1995); Stolle, A., et al. Tetrahedron Lett. 35, 3521 (1994); Burk, M., et al.: J. Am. Chem. Soc. 115, 10125 (1993); Burk, M., et al.: Tetrahedron Asymmetry 2, 569 (1991); Pichon, M., et al: Tetrahedron Asymmetry 7, 927 (1996)<br></p>

<p>Applications 5-METHYLPYRROLIDIN-3-OL (cas# 94134-94-8) is a useful research chemical.<br></p>

<p>Applications A useful synthetic intermediate. Used for asymmetric hydroxylation.<br>References Davis, F.A., et al.: J. Am. Chem. Soc., 112, 6679 (1990)<br></p>

<p>Applications (S)-2-AMINO-1,1-DIPHENYL-1-PROPANOL (cas# 78603-91-5) is a useful research chemical.<br></p>