Estándares farmacéuticos

Applications 2,6-Dimethylanthracene (cas# 613-26-3) is a compound useful in organic synthesis.

Applications Labelled analogue of Crotonobetaine Hydrochloride, a trimethylammonium compound that can be converted into L-Carnitine by Escherichia coli via stereoselective hydration.
References Seim, H. et al.: Eur. Congr. Biotechnol., 1, 481 (1984); Seim, H. et al.: Appl. Microbiol. Biotechnol., 27, 538 (1988);

Applications Benzyl-2,3,4,5,6-d5 trans-Cinnamate (CAS# 347840-02-2) is a useful isotopically labeled research compound.

Applications 4,5,6,7-Tetrahydro-7-oxo-benzo[b]thiophene-4-carboxylic Acid methyl Ester is a useful synthetic intermediate.

Applications 5,8-Dibromo-2-naphthalenecarboxylic Acid is bromo substituted naphthalene carboxylic acid which is a useful research reagent.
References Wang, X., et al.: Ultrasound Sonochemistry, 47,57 (2018)

Applications N-Descyclopropyl N-Allyl Buprenorphine, is the metabolite of Buprenorphine (B689570), an Analgesic that demonstrates narcotic agonist-antagonist properties.
References Martin, W.R., et al.: J. Pharmacol. Exp. Ther., 197, 517 (1976), Rance, M.J., Biochem. Pharmacol., 25, 735 (1976), Heel, R.C., et al.: Drugs, 17, 81 (1979),

Stability Moisture Sensitive
Applications Labelled Phosphoric Acid, used in various chemical processes as a phosphorylating compound. It is involved in the hydrolysis via phosphorylation of nanocrystals to obtain high-aspect-ratio cellulose nanocrystals.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Camarero E. et al.: Biomacromol., 14, 1223 (2013);

Applications A metabolite of Nabumetone.
References Nobilis, M., et al.: J., Pharm., Biomed., Anal., 32, 641 (2003),

Stability Moisture Sensitive
Applications 2,3-Naphthalic anhydride is used as a reagent to synthesize analogues of Thalidomide (T338850), an inhibitor of tumour necrosis factor that was once abandoned because it caused birth defects, but is currently used as an inhibitor of angiogenesis in patients with multiple myeloma.
References D’Amato, R., et al.: Proc. Nat. Acad. Sci., 91, 4082 (1994); Ehrenpreis, E., et al.: Gastroenterology, 117, 1271 (1999); Parma, T., et al.: Nat. Med., 5, 582 (1999); Singhal, S., et al.: New Engl. J. Med., 341, 1565 (1999)

Applications 6-Nitropyrido[2,3-d]pyrimidin-4(3H)-one is a useful research chemical for organic synthesis and other chemical processes.

Applications 1,3-Dicyclohexyl-2-phenyl-pseudourea is an intermediate in the synthesis of [R-(R*,R*)]-(1,2-Dihydroxypropyl)phosphonic Acid (D454455) which is a Fosfomycin (F727500) impurity. Fosfomycin is an antibiotic that exerts a broad spectrum of antibacterial activity. P-[(1R,2R)-1,2-Dihydroxypropyl]-phosphonic Acid is an intermediate in the synthesis of [2-[2-Amino-3-hydroxy-2-(hydroxymethyl)propoxy]-1-hydroxypropyl]phosphonic Acid (A611565), another Fosfomycin (F727500) impurity.
References McGrath, J.W., et al.: Org. Biomolec. Chem., 7, 9 (1944); Goto, M., et al.: Antimicrob. Agents Chemother., 20, 393 (1981);

Stability Moisture Sensitive
Applications 2-Bromo-4’-isopropylacetophenone (cas# 51012-62-5) is a compound useful in organic synthesis.

Applications Tetramethylthiourea (cas# 2782-91-4) is a useful research chemical.

Applications 5-(2-Fluorophenyl)-5-oxovaleric Acid is used as a reagent in the preparation of indole derivatives which act as cell protective agents. It is also used as a reagent in the catalytic N-nitroso aldol reaction of γ,δ-unsaturated δ-lactones.
References Yamamoto, I., et al.: Preparation of indole derivatives as cell protective agents, WO Patent 9745410, Dec 4, 1997; Yanagisawa, A., et al.: Org. Lett., 14, 2434 (2012);

Applications Curcumin β-D-Glucuronide Triacetate Methyl Ester-d3 is an intermediate used in the synthesis of Curcumin β-D-Glucuronide-d3 (C838512), which is a labelled analogue of Curcumin β-D-Glucuronide, a metabolite of Curcumin (C838510) in hepatic tissue and portal blood.
References Sharma, O., et al.: Biochem. Pharmacol., 25, 1811 (1976); Colletti, L., et al.: J. Clin. Invest., 85, 1936 (1990); Sharma, R., et al.: Clin. Cancer Res., 7, 1894 (2001);

Applications 6-methyl-2-oxo-4-[(5,6,7,8-tetrahydronaphthalen-2-yl)amino]-1,2-dihydropyridine-3-carboxylic acid (cas# 1239521-17-5) is a useful research chemical.

Applications An impurity of Docetaxel (D494420).
References Zamir, L., et al.: Tetrahedron Lett., 33, 5173 (1992), Gueritte-Voegelein, F., et al.: J. Med. Chem., 34, 992 (1993), Volk, K., et al.: J. Chromatogr., 696, 99 (1997),

Applications α-2’-Deoxyguanosine is a reagent that forms a β-furanose anomer of imidazolone when photosensitized in the presence of benzophenone.
References Vialas, C., et al.: J. Chem. Soc. Perkin Trans. I, 1201-1206 (1999)

Applications N-Des-tetrahydrofuran N-(6,7-Dimethoxy-4,4a-dihydroquinazolin-4-amine) Alfuzosin-d3 is an isotopic analog of N-Des-tetrahydrofuran N-(6,7-Dimethoxy-4,4a-dihydroquinazolin-4-amine) Alfuzosin (D297955), a dimer impurity of Alfuzosin (A532000).
References Ramage, A.G., et al.: Eur. J. Pharmacol., 129, 307 (1986); Deering, A.H.,: Brit. J. Clin. Pharmacol., 25, 417 (1988); Priolo, L.D., et al.: Eur. J. Clin. Pharmacol., 35, 25 (1988);

Stability Hygroscopic
Applications 6-(dimethylamino)naphthalene-2-carboxylic Acid (cas# 5043-05-0) is a useful research chemical.

Applications B-1-Naphthalenyl-boronic Acid is a useful synthetic intermediate. It is a reagent used to synthesize potassium aryltrifluoroborates which is a convenient precursor of arylboron difluoride lewis acids. It can also be used to prepare high yields of biaryls via Suzuki coupling.
References Vedejs, E., et al.: J. Org. Chem., 60, 3020 (1995); Larhed, M., et al.: Tetrahedron Lett., 37, 8219 (1996); Singh, R., et al.: 7, 1829 (2005)

Applications (3-Nitrophenyl)acetic Acid is a useful synthetic intermediate.
References Strazzolini, P., et al.: J. Org. Chem., 63, 952 (1998)

Applications 9-Methylanthracene-d12 (CAS# 6406-97-9) is a useful isotopically labeled research compound.

Applications N-BENZYL-3,3'-IMINODIPROPIONIC ACID (cas# 6405-28-3) is a useful research chemical.

Applications Tris(4-nitrophenyl)phosphate (cas# 3871-20-3) is a compound useful in organic synthesis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications Intermediate in the preparation of 3,4-Methylenedioxymethamphetamine and its metabolites.
References Pizarro, N., et al.: Bioorg. Med. Chem., 10, 1085 (2002), Milhazes, N., et al.: Chem. Res. Toxicol., 19, 1294 (2006),

Applications 2-Iodo Adenosine 2’,3’-Acetonide (cas# 141018-25-9) is a compound useful in organic synthesis.

Applications 6-Fluoro-1,2,3,4-tetrahydro-naphthalene-2-carboxylic acid (cas# 885269-59-0) is a useful research chemical.

Applications (S)-(4-Nitrophenyl)oxirane is used as a reagent in the enantioconvergent synthesis of the β-blocker (R)-Nifenalol which is based on a combined chemoenzymic approach.
References Paedragosa-Moreau, S., et al.: Tetrahedron, 53, 9707 (1997)

Applications 1,3-Diethyl-2-thiourea (cas# 105-55-5) is a useful research chemical.

Applications 1-Amino-7-naphthalenesulfonic Acid is used as an analyte in the development of several detection and analytical methods.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Pyrzynska, Krystyna: Analy. Sci., 13(4),  629-632 (1997);Hong, S. P., et al.: Chromatographia, 54(1/2), 83-86 (2001)

Applications 4,4’-Dithiobis[2-(1,1-dimethylethyl)-phenol is used as a reactant for the fabrication of coatings based on epoxy resins for environmental protection of microelectronics.
References Krysin, A. P., et al.: Russ. J. Appl. Chem., 86, 997-1000 (2013)

Stability Unstable in Solution
Applications β-Ketoglutaric Acid is used in the synthesis of benzodiazepine derivatives. Also used in the synthesis of orally available hepatitis C virus polymerase inhibitors.
References Jung, D. et al.: Synth. Comm., 29, 1941 (1999); Li, H. et al.: J. Med. Chem., 52, 1255 (2009);

Applications Cholesterol-3-d1 (CAS# 51467-57-3) is a useful isotopically labeled research compound.

Applications Norcamphor is a building block that is used in organic synthesis. Norcamphor has been used as a reactant in the synthesis of cardo-polymers with high gas permeabilities.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Carta, M., et. al.: Polymer Chem., 5, 5255 (2014)

Applications 5-Nitropyridin-2(1H)-one can be used for molecular crystal optical materials.
References Uemya, T., et.al., Jpn. Kokai Tokkyo Koho, 22, (1995);

Stability Hygroscopic
Applications Quercetin Hydrate is a PI 3-kinase inhibitor, GPR30 activator, and apoptosis inducer.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications (+)-trans-Jasmonic Acid is an enantiomer of trans-Jasmonic Acid (J210520) a major constituent of essential oil of Jasmine. Used by the fragrance industry. This product is a clear, colorless to very light yellow oil that adheres to the surface of the vial.
References Hamberg, M., et al.: Biochim. Biophys Acta, 1165, 1 (1992), Tizio, R., et al.: Biocell, 20, 1 (1996), Farmer, E., et al.: Science, 276, 912 (1997),

Applications A potential metabolite of Exemestane (E957000).
References Buzzetti, F., et al.: Steroids, 58, 527 (1993),

Stability Hygroscopic, Temperature Sensitive
Applications Labelled dimethyl phosphorothiolate derivatives used as insecticides.
References Suzuki, F., et al.: Jpn. Tokkyo Koho (1976), JP 51009007 B

Applications Bis(2-nitrophenyl) Sulfide is used in green synthetic preparation of diaryl thioethers via metal-free DBU-based ionic liquid-catalyzed coupling reaction of aryl halides with carbon disulfide.
References Cao, X.T., et al.: New J. Chem., 40, 6762-6767 (2016);

Applications 4-[[2-[2-[(6-Chlorohexyl)oxy]ethoxy]ethyl]amino]-4-oxo-butanoic Acid is an intermediate in the synthesis of HaloTag O2 Tobramycin (H103850). HaloTag O2 Tobramycin is a derivative compound of Tobramycin (T524000), a single factor antibiotic comprising about 10% of nebramycin, the aminoglycosidic antibiotic complex produced by Streptomyces tenebrarius. An Antibacterial.
References Koch, K.F., et al.: Antimicrob. Agents Chemother., 309 (1970); Welles, J.S., et al.: Toxicol. Appl. Pharmacol., 22, 332 (1972); Dash, A.K., et al.: Anal. Profiles Drug Subs. Excip., 24, 579 (1996)

Applications 5-Methoxymethoxy Imidacloprid is an intermediate in the synthesis of 5-Hydroxy-Imidacloprid (H943220), which is a metabolite of Imidacloprid (I274990) which is an active ingredient in certain neuro-active insecticides.
References Chauzat, M., et al.: Env. Entomol., 38, 514 (2009), Patial, A., et al.: Env. Ecol., 27, 320 (2009), Fernandez-Bayo, J., et al.: J. Agric., Food Chem., 57, 5435 (2009), Tomizawa, M., et al.: J. Med. Chem., 52, 3735 (2009), Chem. and Eng. News 90: 10 (2012)

Applications D-Asparagine Methyl Ester is a protected form of D-Asparagine (A788960) which is an isomer of L-Asparagine (A790005). L-Asparagine is used by bacteria (such as Saccharomyces cerevisiae) as a sole nitrogen source for replication. L-Asparagine is also a competitive inhibitor of staphylococcal L-asparaginase and is used as a reagent to synthesize peptide antibiotics.
References Jones, G.: J. Bacteriol., 130, 128 (1977); Perlman, D. & Bodanszey, M.: Ann. Rev. Biochem., 40, 449 (1971); Sobis, M. & Mikucki, J.: Acta Microbiol. Polon., 40, 143 (1990)

Applications Naphthalene-2,3,4,5,6,7,8-d7 (CAS# 887-68-3) is a useful isotopically labeled research compound.

Applications Di(α-tocopherol) Phosphate-d12 is labelled Di(α-tocopherol) Phosphate (T526190) which is used as a vitamin E supplement.
References Libinaki, R., et al.: Food Chem. Toxicol., 44, 916 (2006)

Applications 3'-ethylacetophenone (cas# 22699-70-3) is a useful research chemical.

Applications o-Nitrophenylsulfonyl Chloride is used in the synthesis of renin inhibitors and also anticonvulsants.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Harish, K. et al.: Lett. Drug Des. Disc., 10, 783 (2013); Michida, M. et al.: Org. Proc. Res. Dev., 17, 1430 (2013);

Applications p-Salicylic Acid 4-Sulfate is a urine metabolite of Methylated paraben (B693600), an antimicrobial agent used in cosmetic products.
References Tsukamoto, H., et al: Chem. Pharma. Bull., 10, 86 (1962); Desai, N.B., et al.: J. Sci. Indust. Res., 14, 330 (1955);

Applications 3,5-DIMETHOXYPHENYLACETIC ACID METHYL ESTER (cas# 6512-32-9) is a useful research chemical.

Stability Hygroscopic
Applications 6-Amidino-2-naphthol Methanesulfonate is a useful N-terminal derivatization reagent for improving peptide fragmentation.
References Miyashita, M., et al.: Rapid Commun. Mass Spectrom., 25, 1130 (2011)

Applications Hydroxy Acetildenafil-d4 is the isotope labelled analog of Hydroxy Acetildenafil, which is a Sildenafil (S435000) analog, enhances male sexual function.
References Hou, P., et al.: Food Addit. Contam., 23, 870 (2006), Reepmeyer, J., et al.: J. Pharm. Biomed. Anal., 44, 887 (2007), Park, H., et al.: Food Addit. Contam., 24, 122 (2007),

Applications 2',6'-Dihydroxyacetophenone (cas# 699-83-2) is a compound useful in organic synthesis.

Applications 2-Ethyl-4-pyridinyl-boronic Acid is patented as a reagent to prepare various anti-inflammatory agents.
References Wunberg, T., et a.: PCT Int. Appl. (2010), WO 2010122069 A1 20101028; Wrobleski, S., et al.: PCT Int. Appl. (2012), WO 2012125887 A1 20120920.

Applications 3-Nitrophenylhydrazine Hydrochloride acts as a reagent in the preparation of isosteviol-fused pyrazolines and pyrazoles as potential anticancer agents, preparation of pyrazolobenzothiazines as inhibitors of hepatitis C virus replication.
References Zhu, S., et al.: Eur. J. Med. Chem., 65, 70 (2013); Barreca, M. L., et al.: J. Med. Chem., 56, 2270 (2013);

Applications Ethyl-2-ethoxy-1-[[(2'-cyanobiphenyl-4-yl) methyl] benzimidazole]-7-carboxylate

Applications 3-Chlorosalicylic Acid (cas# 1829-32-9) is a compound useful in organic synthesis.
References Shackelford, J.M.: J.O.C., 26, 4908 (1961)

Applications Chlorhexidine Digluconate Impurity N-d4 Hydrochloride, is labelled Chlorhexidine Digluconate Impurity N (C377660), which is a degradation product found in chlorhexidine digluconate solution.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Revelle, L., et. al.: Pharmaceut. Res., 10, 1777 (1993)

Applications 2'-Bromopropiophenone is used as a reagent to synthesize 2-methyl-3-aminopropiophenones, compounds that exhibit muscle relaxing effects. The ethylene ketal of 2'-bromopropiophenone is used to determine properties of active sites within metal coordination complexes.
References Alaerts, L., et al.: Chem. A Eur. J., 12, 7353 (2006); Shiozawa, A., et al.: Eur. J. Med. Chem., 30, 85 (1995)

Applications 6-(Trifluoromethoxy)-3,4-dihydronaphthalen-1(2H)-one is used in the preparation of pyridine or pyridazine derivatives as histone demethylase inhibitors.
References Chen, Y.K., et. al.: PCT Int. Appl., WO 2014100818 A1 20140626 (2014)

Applications 7-Methoxy-2-naphthol is used as a reactant in the preparation of 9-hydroxy benzopyrene (H829410). It is also used in the preparation of (pyridyl)naphthalenes as highly potent and selective nonsteroidal dual inhibitors of CYP17/CYP11B2 for the treatment of prostate cancer to reduce risks of cardiovascular diseases.
References Pinto-Bazurco Mendieta, M.A.E., et al.: J. Med. Chem. 56, 6101 (2013)

Applications 5-Bromovaleric Acid used in the synthesis of inhibitors for aminoglycoside resistant bacteria. Also used in the preparation of sequence specific base pair mimics as topoisomerase IB inhibitors.
References Vong, K. et al.: ACS Chem. Biol., 7, 470 (2012); Vekhoff, P. et al.: Biochem., 52, 43 (2012);

Applications 4-Bromo-1-naphthoic acid

Applications 5-Methoxy-1-naphthalenol (cas# 3588-80-5) is a compound useful in organic synthesis.

Applications Isotope labelled cis-5-Dodecenoyl Carnitine Inner Salt is an L-carnitine metobolite which are often used to diagnose specific inherited metabolic diseases especially glucose related ones.
References Yang, S. et l.: J. Chrom. B., Anal. Tech. Biomed. Life Sci., 857, 251 (2007);