Derivados de Quinazolina y Quinolina
Las quinazolinas y quinolinas son compuestos heterocíclicos nitrogenados con estructuras aromáticas que desempeñan un papel clave en la síntesis de fármacos con actividad anticancerígena, antimicrobiana y antiinflamatoria. Sus derivados presentan modificaciones estructurales que optimizan su biodisponibilidad y selectividad, lo que permite el desarrollo de nuevos principios activos para diversas aplicaciones terapéuticas. Estos compuestos se utilizan en la fabricación de APIs destinados al tratamiento de cáncer, infecciones, enfermedades neurodegenerativas y cardiovasculares. Además, los derivados de quinazolina y quinolina son esenciales en la investigación de inhibidores enzimáticos y en el diseño de moléculas bioactivas innovadoras. En CymitQuimica disponemos de derivados de quinazolina y quinolina de alta pureza para aplicaciones en síntesis química, desarrollo farmacéutico y biotecnología.
Se han encontrado 65576 productos de "Derivados de Quinazolina y Quinolina"
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1-(3,4-Dimethylphenyl)ethanol
CAS:Producto controlado<p>Applications 1-(3,4-Dimethylphenyl)ethanol is an intermediate in the production of Medetomidine (M203250), α2-Adrenergic agonist. Sedative; analgesic.<br>References Kagechika, H., et al.: J. Med. Chem., 32, 1098 (1989), ; Scheinin, M., et al.: Br. J. Clin. Pharmacol., 24, 443 (1987),<br></p>Fórmula:C10H14OForma y color:NeatPeso molecular:150.22N-trifluoroacetyl Varenicline
CAS:Producto controlado<p>Applications 7,8,9,10-Tetrahydro-8-(trifluoroacetyl)-6,10-methano-6H-pyrazino[2,3-h][3]benzazepine is used to prepare varenicline, which is a smoking cessation. It is a Varenicline protected impurity.<br>References Coe, J., et al.: J. Med. Chem., 48, 3474 (2005) ;<br></p>Fórmula:C15H12F3N3OForma y color:NeatPeso molecular:307.27052S,3S,5S-5-Amino-2-[N-[[(5-thiozolyl)methoxy]carbonyl]amino]-1,6-diphenyl-3-hydroxyhexane
CAS:Producto controladoFórmula:C23H27N3O3SForma y color:NeatPeso molecular:425.54Ibrutinib Dimer (~90%)
CAS:<p>Applications Ibrutinib Dimer is a dimer impurity of Ibrutinib (I124970), a highly selective Bruton’s tyrosine kinase (Btk) irreversible inhibitor.<br>References MacGlashan, D., et. al.: Int. Immunol., 11, 475 (2011)<br></p>Fórmula:C50H48N12O4Pureza:~90%Forma y color:NeatPeso molecular:880.991-Benzo[b]thien-4-yl-piperazine
CAS:Producto controlado<p>Applications is an intermediate in synthesizing Brexpiprazole 5-1H-Quinolin-2-one (B677428), an impurity of Brexpiprazole (B677385), which is a drug candidate useful in treatment and prevention of mental disorders including CNS disorders.<br>References Yamashita, H., et al.: PCT Int. Appl., WO 2006112464 A1 20061026 (2006)<br></p>Fórmula:C12H14N2SForma y color:NeatPeso molecular:218.32α,α'-Diethyl-4,4'-stilbenediol-d4
CAS:Producto controlado<p>Applications α,α'-Diethyl-4,4'-stilbenediol-d4 is an intermediate in the synthesis of d in the synthesis of isotope labelled metabolites of Diethylstibestrol (D445026).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Schuller, P.L., et al.: J. Chromatograph., 31, 237 (1967);<br></p>Fórmula:C18H16D4O2Forma y color:NeatPeso molecular:272.372-Amino-5-cyanobenzotrifluoride
CAS:Producto controlado<p>Applications 2-Amino-5-cyanobenzotrifluoride is used in the design and synthesis of 4-phenylpyrrole derivatives as androgen receptor antagonists which show efficacy against prostate cancer cells.<br>References Yamamoto, S. et al.: Bioorg. Med. Chem. Lett., 20, 422 (2012), Chen, J. et al.: Synth. Met., 160, 1953 (2010);<br></p>Fórmula:C8H5F3N2Forma y color:NeatPeso molecular:186.1339N10-Monodesmethyl Rizatriptan
CAS:Producto controlado<p>Impurity Rizatriptan EP Impurity I<br>Applications N10-Monodesmethyl Rizatriptan (Rizatriptan EP Impurity I) is a metabolite of Rizatriptan.<br>References Dechant, K., et al.: Drugs, 43, 776 (1992), Castro, J., et al.: Bioorg. Med. Chem. Lett., 3, 993 (1993), Lee, Y., et al.: Biopharm. Drug Dispos., 19, 577 (1998), Chen, J., et al.: J. Pharm. Biomed. Anal., 35, 639 (2004),<br></p>Fórmula:C14H17N5Forma y color:NeatPeso molecular:255.321,3-Dichloroacetone
CAS:Producto controlado<p>Applications 1,3-Dichloroacetone (cas# 534-07-6) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>Fórmula:C3H4Cl2OForma y color:NeatPeso molecular:126.974,5-Dichlorothiophene-2-carboxylic Acid
CAS:Producto controlado<p>Applications 4,5-Dichlorothiophene-2-carboxylic Acid is used in the preparation of compounds that have therapeutic BACE1 and BACE2 inhibitors which are used for the treatment of Alzheimer’s disease, type 2 diabetes and other metabolic disorders.<br>References Banner, D., et al.: PCT Int. Appl., 2011:1438553 (2013)<br></p>Fórmula:C5H2Cl2O2SForma y color:NeatPeso molecular:197.04Haloperidol pyridinium Chloride Impurity
CAS:Producto controlado<p>Applications Haloperidol pyridinium Chloride is a neurotoxic pyridinium metabolite of haloperidol that is formed in the liver and found in the brain. Haloperidol pyridinium Chloride is a substrate for human organic cation transporters.<br>References Kang, H. et. al.: Drug Metab. Dispos., 34, 1145 (2006)<br></p>Fórmula:C21H18Cl2FNOForma y color:NeatPeso molecular:390.28N-Despropyl Ropinirole-d3
CAS:Producto controlado<p>Applications An isotopically Labelled metabolite of Ropinirole.<br>References Coldwell, M., et al.: Br. J. Pharmacol., 127, 1135(1999), Ramji, J., et al.: Xenobiotica, 29, 311 (1999)<br></p>Fórmula:C13H15D3N2OForma y color:NeatPeso molecular:221.31Tofogliflozin
CAS:Producto controlado<p>Applications A novel, potent, and highly selective SGLT2 inhibitor that has been shown to improve glycemic control in diabetic mice and rats.<br></p>Fórmula:C22H26O6Forma y color:NeatPeso molecular:386.44Dasatinib Carboxylic Acid
CAS:Producto controlado<p>Applications An oxidative metabolite of Dasatinib (M6 metabolite); used in the treatment of cancers and immune diseases. It is a COVID19-related research product.<br>References Jaworski, T., et al.: Xenobiotica, 21, 1451 (1991), Shah, N., et al.: Science, 305, 399 (2004), O'Hare, T., et al.: Cancer Res., 65, 4500 (2005), Das, J., et al.: J. Med. Chem., 49, 6819 (2006), Christopher, L., et al.: Drug Metab. Dispos., 36, 1341 (2008),<br></p>Fórmula:C22H24ClN7O3SForma y color:Light YellowPeso molecular:501.99N-[(2,4-Difluorophenyl)methyl]-1,8-dihydro-9-hydroxy-2-[(1R)-3-hydroxy-1-methylpropyl]-1,8-dioxo-2H-pyrido[1,2-a]pyrazine-7-carboxamide
CAS:Producto controladoFórmula:C20H19F2N3O5Forma y color:YellowPeso molecular:419.38N-[4-Cyano-3-(trifluoromethyl)phenyl]-2-methylacrylamide
CAS:Producto controlado<p>Stability Light Sensitive<br>Applications N-[4-Cyano-3-(trifluoromethyl)phenyl]-2-methylacrylamide was used to prepare and observe selective androgen receptor modulator activity.<br>References Zhang, X., et al.: Bioorg. Med. Chem. Lett., 16, 5763 (2006).<br></p>Fórmula:C12H9F3N2OForma y color:NeatPeso molecular:254.20794-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine
CAS:Producto controlado<p>Applications 4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine is a reagent in the synthesis of (+)-tofacitinib, a selective Janus kinase 3 inhibitor (JAK3) and an immunosuppressant drug.<br>References Liao, H., et al.: Tetrahedron: Asymmetry, 28, 105, (2017)<br></p>Fórmula:C13H10ClN3O2SForma y color:NeatPeso molecular:307.76rac Pimobendan
CAS:Producto controlado<p>Applications Pimobendan is a cardiotonic agent. The study of the cardiotonic mechanism of Pimobendan using ventricular muscles from rabbits and guinea pigs suggests that Pimobendan acts by inhibiting phosphodiesterase III and potassium channel. The potent venodilating action of Pimobendan makes it a suitable treatment option for patients with congestive heart failure (CHF) as it also improves systemic vasoconstriction.<br>References Yokota, S. et al.: Yakuri Chiryo, 20, 1143 (1992); Yamamoto, M. et al.: Kank. Igaku Ken. Nenpo, 47, 155 (1996); Matsumoto, A. et al.: Cardiovas. Drugs Ther., 12, 595 (1998);<br></p>Fórmula:C19H18N4O2Forma y color:NeatPeso molecular:334.37Cinitapride
CAS:<p>Applications A novel prokinetic benzamide-stimulating gastrointestinal motility agent and antiucer agent. It acts as an agonist of the 5-HT1 and 5-HT4 receptors and as an antagonist of the 5-HT2 receptors (1,2,3).<br>References (1) Alarcon de la Lastra, C. et al.: Pharmacol, 54, 193 (1997)(2) Robert, M. et al.: Drug Metab. Disp., 35, 1149 (2007)(3) Alarcon de la Lastra, C. et al.: Inflam. Res., 47, 131 (1998)<br></p>Fórmula:C21H30N4O4Forma y color:NeatPeso molecular:402.49Des(methylpiperazinyl-N-methyl) Imatinib Dimer Impurity
CAS:<p>Applications Des(methylpiperazinyl-N-methyl) Imatinib Dimer is an impurity of Imatinib (Gleevec) (G407000). Imatinib impurity E. It is a COVID19-related research product.<br></p>Fórmula:C52H48N12O2Forma y color:White To Off-WhitePeso molecular:873.02N-Nitrososotalol-d6
CAS:Producto controladoFórmula:C12D6H13N3O4SForma y color:Off-WhitePeso molecular:307.399(S)-4-Hydroxy Propranolol Hydrobromide
CAS:Producto controlado<p>Applications (S)-4-Hydroxy Propranolol is the main metabolite of (S)-Propranolol (P831795).<br>References Shwed, J., et al.: Xenobiotica, 22, 973 (1992), Fujita, K., et al.: Biol. Pharm. Bull., 22, 446 (1999), Walle, U., et al.: Drug Metab. Dispos., 30, 564 (2002),<br></p>Fórmula:C16H21NO3·ClHForma y color:NeatPeso molecular:311.804-(6-Nitro-3-pyridinyl)-1-nitroso-piperazine
CAS:Producto controladoFórmula:C9H11N5O3Forma y color:NeatPeso molecular:237.215Carvedilol Bisalkylpyrocatechol Impurity
CAS:Producto controlado<p>Applications A new known impurity of Carvedilol (C184625), published in Carvedilol USP monograph.<br></p>Fórmula:C40H42N4O6Forma y color:NeatPeso molecular:674.78Azilsartan Imidazole Carbonyl Dioxolene Ester
CAS:<p>Applications Azilsartan Imidazole Carbonyl Dioxolene Ester is an impurity of Azilsartan (A926900), an analgesic and antiinflammatory drugs containing angiotensin II antagonists.<br>References Kohara, Y., et al.: J. Med. Chem., 39, 5228 (1996), Plomgaard, P., et al.: Diabetes, 54, 2939 (2005), Fenton, C., et al.: Drugs, 2005, 65, 537,<br></p>Fórmula:C33H28N6O8Forma y color:NeatPeso molecular:636.61Bicalutamide Sulfoxide
CAS:Producto controlado<p>Impurity Bicalutamide USP Related Compound A<br>Applications Bicalutamide Sulfoxide is a derivative of Bicalutamide (B382000), non-steroidal peripherally active antiandrogen. Used as an antiandrogen, antineoplastic (hormonal).<br>References Tucker, H., et al.: J. Med. Chem., 31, 954 (1988), Cockshott, I.D., et al.: Eur. Urol., 18, Suppl. 3, 10 (1990), Cockshott, I., et al.: Br. J. Clin. Pharm., 36, 339 (1993), McKillop, D., et al.: Xenobiotica, 25, 623 (1995),<br></p>Fórmula:C18H14F4N2O3SForma y color:NeatPeso molecular:414.37Desmethyl Nintedanib Carboxylic Acid (Nintedanib Impurity A)
Producto controlado<p>Applications Desmethyl Nintedanib Carboxylic Acid is an impurity of Intedanib (I666650), which is an indolinone derivative potently blocking VEGF-, PDGF-, and FGF-receptor kinases. it is an indolinone as triple angiokinase inhibitors and an antitumor agent.<br>References Sun, L., et al.: J. Med. Chem., 41, 2588 (1998); Xie, H., et al.: J. Med. Chem., 50, 4898 (2007); Hilberg, F., et al.: Cancer Res., 68, 4774 (2008); Roth, G., et al.: J. Med. Chem., 58, 1053 (2015)<br></p>Fórmula:C29H29N5O5Forma y color:NeatPeso molecular:527.572-Hydroxy Imipramine β-D-Glucuronide
CAS:Producto controlado<p>Applications A metabolite of Imipramine.<br>References Gram, L.F., et al.: Clin. Pharmacol. Therap., 17, 555 (1975), Hackett, A.M., et al.: Xenobiotica, 14, 491 (1984), Chiba, M., et al.: Biochem. Pharmacol., 39, 367 (1990),<br></p>Fórmula:C25H32N2O7Forma y color:NeatPeso molecular:472.53Ethyl 2-[N-[(2'-Cyanobiphenyl-4-yl)methyl]amino]-3-nitrobenzoate
CAS:<p>Applications Ethyl 2-[N-[(2'-Cyanobiphenyl-4-yl)methyl]amino]-3-nitrobenzoate is a useful reagent in synthesis of candesartan cilexitil.<br>References Zhu, Y., et al.: Zhongguo Yaowu Huaxue Zazhi, 13, 31 (2003); Cao, R., et al.: Zhongguo Yiyao Gongye Zazhi, 34, 425 (2003);<br></p>Fórmula:C23H19N3O4Forma y color:NeatPeso molecular:401.414-[[3-(4-Methylphenyl)-3-oxo-1-(trifluoromethyl)propylidene]amino]benzenesulfonamide
CAS:Producto controlado<p>Applications 4-[[3-(4-Methylphenyl)-3-oxo-1-(trifluoromethyl)propylidene]amino]benzenesulfonamide, is an impurity of Celecoxib (C251000), which is a selective cyclooxygenase-2 (COX-2) inhibitor, an anti-inflammatory agent. It is also used in treatment of familial adenomatous polyposis.<br>References Simon, L.S., et al.: Arthritis Rheum., 41, 1591 (1998), Silverstein, F.E., et al.: J. Am. Med. Assoc., 284, 1247 (2000), Steinbach, G., et al.: N. Engl. J. Med., 342, 1946 (2000),<br></p>Fórmula:C17H15F3N2O3SForma y color:YellowPeso molecular:384.37Pimavanserin N-Oxide
CAS:Producto controlado<p>Applications Pimavanserin N-Oxide is an impurity of Pimavanserin (P441800), a drug used in the treatment of Parkinson’s disease and psychosis.<br>References Snigdha, S., et al.: J. Pharmacol. Exper. Ther., 332, 622 (2010); Meltzer, H., et al.: Neuropsychopharmacol., 35, 881 (2010);<br></p>Fórmula:C25H34FN3O3Forma y color:NeatPeso molecular:443.55N-Methyl-o-phenylenediamine, Dihydrochloride
CAS:Producto controladoFórmula:C7H10N2·2ClHForma y color:NeatPeso molecular:195.096-Oxo-(S,S)-Palonosetron (~90%)
CAS:Producto controlado<p>Applications 6-Oxo-(S,S)-Palonosetron is an impurity of (S,S)-Palonosetron (P165800), a serotonin 5-HT3 receptor antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). Antiemetic.<br>References Clark, R.D., et al.: J. Med. Chem., 36, 2645 (1993), Wong, E.H.F., et al.: Br. J. Pharmacol., 114, 851 (1995), Grunberg, S.M., et al.: Expert. Opin. Pharmacother., 4, 2297 (2003), Eisenberg, P., et al.: Ann. Oncol., 15, 330 (2004), Siddiqui, M.A.A., et al.: Drugs, 64, 1125 (2004),<br></p>Fórmula:C19H22N2O2Pureza:~90%Forma y color:NeatPeso molecular:310.39N,O-Diacetyl Pseudoephedrine
CAS:Producto controlado<p>Applications N,O-Diacetyl Pseudoephedrine is the diacetylated analogue of the non-selective adrenergic agonist Pseudoephedrine (P839350).<br></p>Fórmula:C14H19NO3Forma y color:NeatPeso molecular:249.311-Phenyl-2-propen-1-one (Contains ~1% BHT as stabilizer)
CAS:<p>Stability Light and Temperature Sensitive<br>Applications 1-Phenyl-2-propen-1-one is a chemical reagent used in the synthesis of pharmaceutical agents. Used in the preparation of functionalized aminoindolizines as well as pyrano[3,2-x]coumarins.<br>References Wang, D. et al.: Asian J. Org. Chem., 2, 480 (2013); Gohain, M. et al.: Tetrahedron Lett., 54, 3773 (2013);<br></p>Fórmula:C9H8OForma y color:NeatPeso molecular:132.159rac 4-(3-Aminobutyl)phenol
CAS:Producto controlado<p>Applications A metabolite of the antihypertensive agent, Labetalol (L096500).<br>References Gal, J., et al.: Res. Comm. Chem. Pathol. Pharmacol., 62, 3 (1988),<br></p>Fórmula:C10H15NOForma y color:NeatPeso molecular:165.23N-[[N-Methyl-N-[(2-isopropyl]-4-thiazolyl)methyl)amino]carbonyl-L-valine Carboxylic Acid
CAS:Producto controlado<p>Impurity Ritonavir EP Impurity A<br>Applications N-[[N-Methyl-N-[(2-isopropyl]-4-thiazolyl)methyl)amino]carbonyl-L-valine Carboxylic Acid (Ritonavir EP Impurity A) is an intermediate in the synthesis of Ritonavir.<br>References Hamada, Y., et al.: Bioorg. Med. Chem., 10, 4155 (2002),<br></p>Fórmula:C14H23N3O3SForma y color:NeatPeso molecular:313.42Ivabradine-d3 Hydrochloride
CAS:Producto controlado<p>Stability very hygroscopic<br>Applications Labelled Ivabradine (I940500). Selective bradycardic agent with direct effect on the pacemaker If current of the sinoatrial node. Antianginal.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Thollon,C., et al.: Br. J. Pharmacol., 112, 37 (1994), Ragueneau, I., et al.: Clin. Pharmacol. Ther., 64, 192 (1998), Borer, J.S., et al.: Circulation, 107, 817 (2003), DiFrancesco, D., et al.: Drugs, 64, 1757 (2004),<br></p>Fórmula:C272H3H33N2O5·ClHForma y color:NeatPeso molecular:508.06Perampanel-d5
CAS:Producto controlado<p>Applications Perampanel-d5, is the labeled analogue of Perampanel (P285520), an antiepileptic drug.<br>References Shih, J., et al.: Therap. Clinical Risk Management, 9, 285 (2013); Rogawski, M. A., et al.: Epilepsy Curr., 11, 56 (2011);<br></p>Fórmula:C23D5H10N3OForma y color:Light Orange Colour SolidPeso molecular:354.42(3Z)-2,3-Dihydro-3-[[[4-(methylamino)phenyl]amino]phenylmethylene]-2-oxo-1H-Indole-6-carboxylic Acid Methyl Ester
CAS:Producto controladoFórmula:C24H21N3O3Forma y color:NeatPeso molecular:399.44β-Tetralone
CAS:Producto controlado<p>Applications β-Tetralone is the 2-keto derivative of Tetralin. β-Tetralone was initially reported to be a metabolite of Tetralin but was later found to be just an artifact in the metabolism process. β-Tetralone is known to be biological marker in fossil fuels.<br>References Elliott, T.H. et al.: Biochem. J., 108, 551 (1968); Armstrong, D. et al.: Microchem. J., 57, 149 (1997);<br></p>Fórmula:C10H10OForma y color:NeatPeso molecular:146.19Nitroso Norquetiapine-d8
Producto controladoFórmula:C17D8H8N4OSForma y color:NeatPeso molecular:348.449Isopropyl 4-Hydroxy-2H-1,2-benzothiazine-3-carboxylate 1,1-Dioxide (Piroxicam Impurity I)
CAS:Producto controlado<p>Impurity Piroxicam EP Impurity I<br>Applications Piroxicam impurity I.<br>References Lombardino, J., et al.: J. Med. Chem., 14, 1171 (1971), Turck, D., et al.: Clin. Drug Invest., 9, 270 (1995),<br></p>Fórmula:C12H13NO5SForma y color:NeatPeso molecular:283.3N’-Benzylidene-2-ethoxybenzimidohydrazide Hydroiodide
Producto controladoFórmula:C16H17N3O·HIForma y color:Off-WhitePeso molecular:395.238(R)-Levetiracetam
CAS:Producto controlado<p>Impurity Levetiracetam EP Impurity D<br>Applications (R)-Levetiracetam [REV] (Levetiracetam EP Impurity D), is the enantiomer to Levetiracetam [LEV] (L331500), the antiepileptic drug that is highly enantioselective. It is apparent that [LEV] is more potent than [REV] in terms of antiepileptic potency.<br>References Isoherranen, N. et al.: Epilepsia, 42, 825 (2001); Isoherranen, N. et al.: Epilepsia, 44, 1280 (2003);<br></p>Fórmula:C8H14N2O2Forma y color:NeatPeso molecular:170.21R-(-)-N-Demethyl Deprenyl
CAS:Producto controlado<p>Applications A metabolite of Deprenyl (D288641) (Selegiline).<br>References Dyck, L., et al.: Drug Metab. Dispos., 29, 1156 (2001), Damaj, M., et al.: J. Pharmacol. Exp. Ther., 320, 250 (2007),<br></p>Fórmula:C12H15N·ClHForma y color:NeatPeso molecular:209.72Dipyridamole Tripiperidine
CAS:Producto controlado<p>Impurity Dipyridamole EP Impurity A<br>Applications Dipyridamole Tripiperidine (Dipyridamole EP Impurity A) is a Dipyridamole (D492625) impurity.<br>References Bakken, G.A., et al.: J. Med. Chem., 43, 4534 (2000),<br></p>Fórmula:C25H40N8O2Forma y color:NeatPeso molecular:484.64Methyl 5,6,7,8-Tetradehydro Risperidone
CAS:Producto controlado<p>Applications An internal standard for Risperidone (R525000).<br>References Jannssen, P.A.J., et al.: J. Pharmacol. Exp. Ther., 244, 685 (1988), Gelders, Y.G., et al.: Pharmacopsychiatry, 23, 206 (1990), Green, B.: Curr. Med. Res. Opin., 16, 57 (2000)<br></p>Fórmula:C24H25FN4O2Forma y color:White To Off WhitePeso molecular:420.48Tadalafil-13C2,d3
CAS:Producto controlado<p>Applications Tadalafil-13C2,d3 is labelled Tadalafil (T004500) which is used for the treatment of erectile dysfunction. It is a phosphodiesterase 5 inhibitor.<br>References Carrier, S., et al.: Can. J. Urol., 10(1), 12 (2003), Doggrell, S.A., et al.: Expert Opin. Pharmacother., 6, 75 (2005), Forgue, S.T., et al.: Br. J. Clin. Pharmacol., 61, 280 (2005)<br></p>Fórmula:C2013C2H16D3N3O4Forma y color:White PowderPeso molecular:394.41N,N'-bis(2,6-Dimethylphenyl)-1,4-piperazinediacetamide
CAS:Producto controlado<p>Impurity Ranolazine USP Related Compound D<br>Applications N,N'-bis(2,6-Dimethylphenyl)-1,4-piperazinediacetamide is an intermediate of Ranolazine (R122500), an anti-ischemic agent which modulates myocardial metabolism. Ranolazine is also known to exert antianginal activities.<br>References Sampath, A., et al.: Org. Proc. Rsch. Dev., 16, 748 (2012); Chaitman, B.R., et al.: J. Am. Coll. Cardial., 43, 1375 (2004); McCormack, J.G., et al.: Gen. Pharmacol., 30, 639 (1998); Schofield, J.A.H., et al.: Expert Opin. Invest. Drugs, 11, 117 (2002)<br></p>Fórmula:C24H32N4O2Forma y color:NeatPeso molecular:408.54N-Des(4-Fluorophenyl)-N-(3-chlorophenyl)-ezetimibe
CAS:Producto controladoFórmula:C24H21ClFNO3Forma y color:NeatPeso molecular:425.88Varenicline-d2,15N2 Dihydrochloride
CAS:Producto controlado<p>Applications Varenicline-d2,15N2 Dihydrochloride, is the labelled dihydrochloride salt of Varenicline (V098492), a nicotinic α4β2 acetylcholine receptor partial agonist. Aids in smoking cessation.<br>References Benowitz, N., et al.: Clin. Pharmacol. Ther., 44, 23 (1988), Cohen, C., et al.: J. Pharmacol. Exp. Ther., 306, 407 (2003), Tapper, A., et al.: Science, 306, 1029 (2004), Coe, J., et al.: J. Med. Chem., 48, 3474 (2005), Obach, R., et al.: Drug Metab. Disp., 34, 121 (2006),<br></p>Fórmula:C13H13D2Cl2N15N2Forma y color:Light Beige SolidPeso molecular:288.18(2R,6S)-rel-2,6-Dimethyl-4-(2-methyl-3-phenylpropyl)morpholine Hydrochloride
CAS:<p>Impurity Amorolfine EP Impurity C<br>Stability Hygroscopic<br>Applications (2R,6S)-rel-2,6-Dimethyl-4-(2-methyl-3-phenylpropyl)morpholine Hydrochloride (1:1), is used in the preparation of Amorolfine (A634170), a morpholine antifungal drug.<br>References Rotta, I., et al.: JAMA Dermatol., 149, 341 (2013); Espinel-Ingroff, A., et al.: Antimicrob. Agents Ch., 26, 5 (1984)<br></p>Fórmula:C16H26ClNOForma y color:NeatPeso molecular:283.843-Chlorobenzyl Cyanide
CAS:Producto controlado<p>Applications 3-Chlorobenzyl Cyanide is a useful synthetic intermediate. It was used to design EGFR Tyrosine Kinase Inhibitors. It can also be used to synthesize imidoyl thioureas as non-nucleoside reverse transcriptase inhibitors.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Traxler, P., et al.: J. Med. Chem., 42, 1018 (1999); Ludovici, D., et al.: Bioorg. Med. Chem. Lett., 11, 2225 (2001)<br></p>Fórmula:C8H6ClNForma y color:NeatPeso molecular:151.592,4-Difluorobenzoic Acid
CAS:Producto controlado<p>Applications 2,4-Difluorobenzoic Acid (cas# 1583-58-0) is a compound useful in organic synthesis.<br></p>Fórmula:C7H4F2O2Forma y color:NeatPeso molecular:158.10rac O-Acetyl Pseudoephedrine Hydrochloride
CAS:Producto controlado<p>Applications rac O-Acetyl Pseudoephedrine is a racemic O-acetylated analogue of the non-selective adrenergic agonist Pseudoephedrine (P839350).<br>References Snopek, J. et al.: J. Chrom., 438, 211 (1988);<br></p>Fórmula:C12H17NO2·ClHForma y color:WhitePeso molecular:243.73Safinamide-d4
CAS:Producto controlado<p>Applications Safinamide-d4 is a labelled analogue of Safinamide. Safinamide is a potent and selective MAO-B inhibitor, and is used as an add-on treatment to treat Parkinson’s disease.<br>References Finberg, J.P.M., et al.: Front Pharmacol., 7, 340-54 (2016);<br></p>Fórmula:C17D4H15FN2O2Forma y color:NeatPeso molecular:306.3684-(Methylamino)-3-nitrobenzoic Acid
CAS:Producto controlado<p>Applications 4-(Methylamino)-3-nitrobenzoic Acid (cas# 41263-74-5) is a compound useful in organic synthesis.<br></p>Fórmula:C8H8N2O4Forma y color:NeatPeso molecular:196.16Ibrutinib Addition Adduct with (R)-1-(3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)
CAS:Fórmula:C47H46N12O3Forma y color:Off-WhitePeso molecular:826.952-(1-aminocyclohexyl)acetic acid
CAS:Producto controladoFórmula:C8H15NO2Forma y color:NeatPeso molecular:157.21Elvitegravir-d6 (Major)
CAS:Producto controlado<p>Applications A novel labelled inhibitor of human immunodeficiency virus type 1 integrase.<br>References Chou, T., et al.: Eur. J. Biochem., 115, 207 (1981), Baba, M., et al.: Antimicrob. Agents Chemother., 31, 1613 (1987), Craigie, R., et al.: J. Biol. Chem., 276, 23213 (2001), Chen, X., et al.: J. Mol. Biol., 380, 504 (2008),<br></p>Fórmula:C23H17D6ClFNO5Forma y color:NeatPeso molecular:453.914-Hydroxy Propranolol β-D-Glucuronide (Mixture of Diastereomers)
CAS:Producto controlado<p>Applications A metabolite of 4-Hydroxy propranolol. Antihypertensive; antianginal; antiarrhythmic (class II).<br>References Walle, T., et al.: Clin. Pharmacol. Ther., 46, 257 (1989), Christ, D.D., et al.: Drug Metab. Dispos., 18, 1 (1990),<br></p>Fórmula:C22H29NO9Forma y color:NeatPeso molecular:451.472-(1-Amino-1-methylethyl)-N-(4-fluorobenzyl)-5-hydroxy-1-methyl-6-oxo-1,6-dihydropyrimidine-4-carboxamide
CAS:Producto controlado<p>Applications An intermediate in the preparation of HIV-integrase inhibitors<br>References Summa, V., et al.: J. Med. Chem., 51, 5843 (2008),<br></p>Fórmula:C16H19FN4O3Forma y color:NeatPeso molecular:334.35Moclobemide N-Oxide
CAS:<p>Applications Moclobemide N-Oxide is a metabolite of Moclobemide (M481000), a reversible monoamine oxidase inhibitor.<br>References Plenis, A., et. al.: Biomed. Chrom., 21, 958 (2007); Rakic, A., et. al.: J. Pharmaceut. Biomed. Anal., 43, 1416 (2007); Wiesel, F.A., et al.: Eur. J. Clin. Pharmacol., 28, 89 (1985), Burkard, W.P., et al.: J. Pharmacol. Exp. Ther., 248, 391 (1989)<br></p>Fórmula:C13H17ClN2O3Forma y color:NeatPeso molecular:284.74N-[2(4-(-Octylphenyl))butanoic Acid] Fingolimod
CAS:Producto controlado<p>Applications N-[2(4-(-Octylphenyl))butanoic Acid] Fingolimod, is an impurity of Fingolimod (F805000, HCl salt). Fingolimod is a novel immune modulator that prolongs allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs.<br>References Brinkmann, V., et al.: Transplantation, 72, 764 (2001), Brinkmann, et al.: J. Biol. Chem., 277, 24, 21453 (2002), Mtaloubian, M., et al.: Nature, 427, 355 (2004),<br></p>Fórmula:C37H59NO4Forma y color:NeatPeso molecular:581.872',6'-Dichloroacetanilide
CAS:Producto controladoFórmula:C8H7Cl2NOForma y color:NeatPeso molecular:204.053-Amino-4-(2,4,5-trifluorophenyl)butanyl Sitagliptin
CAS:Producto controlado<p>Applications 3-Amino-4-(2,4,5-trifluorophenyl)butanyl Sitagliptin is an impurity of Sitagliptin (S490990). Sitagliptin is a trizolopyrazine dipeptidyl peptidase IV inhibitor. It has recently been approved for the therapy of type II diabetes.<br>References Kim, D., et al.: J. Med. Chem., 48, 141 (2005), Ahren, B., et al.: Eur. J. Pharmacol., 521 164 (2005), Bergman, A., et al: Clin. Ther., 28, 55 (2006)<br></p>Fórmula:C26H23F9N6O2Forma y color:NeatPeso molecular:622.48542-(Chloromethyl)-4-methoxy-3,5-dimethylpyridine Hydrochloride
CAS:Producto controlado<p>Impurity Omeprazole EP Impurity XI<br>Applications 2-(Chloromethyl)-4-methoxy-3,5-dimethylpyridine Hydrochloride (Omeprazole EP Impurity XI) is an intermediate in the production of the antiulcer agent Omeprazole.<br>References Roma, G., et al.: J. Med. Chem., 50, 2886 (2007), Hoffmann, S., et al.: Toxicol. Lett., 180, 9 (2008),<br></p>Fórmula:C9H12ClNO·ClHForma y color:WhitePeso molecular:222.11(2S,4S)-Argatroban
CAS:Producto controlado<p>Applications Synthetic thrombin inhibitor. Antithrombotic.<br>References Abiko, Y., et al.: Thromb. Res., 24, 285 (1981), Kikumoto, R., et al.: Biochemistry, 23, 85 (1984),<br></p>Fórmula:C23H36N6O5SForma y color:NeatPeso molecular:508.631-(1H-Benzo[d]imidazol-2-yl)-3-methyl-4-oxo-1,4-dihydropyridine-2-carboxylic acid (>75%)
CAS:<p>Impurity Rabeprazole EP Impurity C<br>Applications 1-(1H-Benzo[d]imidazol-2-yl)-3-methyl-4-oxo-1,4-dihydropyridine-2-carboxylic acid (>75%) (Rabeprazole EP Impurity C) is a Rabeprazole (R070500) impurity. A degradation product formed in stressed tablets of Rabeprazole sodium.<br>References Kommanaboyina, B., et al.: Drug Dev. Ind. Pharm., 25, 857 (1999), Carswel, C., et al.: Drugs, 61, 2327 (2001), Garcia, C., et al.: J. Pharm. Biomed. Anal., 46, 88 (2008),<br></p>Fórmula:C14H11N3O3Pureza:>75%Forma y color:NeatPeso molecular:269.26O-De(3-fluorobenzyl) Lapatinib Ditosylate Salt
CAS:Producto controlado<p>Applications A reactive metabolite of Lapatinib (L175800) which is associated with various drug toxicities. Lapatinib is metabolized mainly by P450 3A4 to form O- and N-dealkylated metabolites.<br>References He, K., et al.: Chem. Res. Toxicol., 11, 252 (1998), Rusnuk, D., et al.: Cancer Res., 61, 7196 (2001), Li, X., et al.: Drug Metab. Dispos., 37, 1242 (2009),<br></p>Fórmula:C36H37ClN4O10S3Forma y color:NeatPeso molecular:817.35Repirinast (>80%)
CAS:Producto controladoFórmula:C20H21NO5Pureza:>80%Forma y color:NeatPeso molecular:355.388-Bromo-3,9-dihydro-3-methyl-1H-purine-2,6-dione
CAS:<p>Applications 8-Bromo-3,9-dihydro-3-methyl-1H-purine-2,6-dione, is a substituted derivative of Xanthine (X499950), found in animal organs, yeast, potatoes, coffee beans, tea. It can also be used for the synthesis of Linagliptin (L465900), which is a novel potent and selective dipeptidyl peptidase-4 (DPP-4) inhibitor with potential use in the treatment of type 2 diabetes.<br>References Mueller, C. et. al: Handbook Exp. Pharmacol. 200,151(2011); Prabavathy, N. et al.: Int. J. Pharm. Bio. Sci., 2, 438 (2011); Deacon, C.F.: Diab. Obes. Metab., 13, 7 (2011); Mtthias E., et. al: J. Med. Chem., 50, 6450 (2007);<br></p>Fórmula:C6H5BrN4O2Forma y color:NeatPeso molecular:245.035-Hydroxy Propranolol Hydrochloride
CAS:Producto controlado<p>Applications A metabolite of Propranolol.<br>References Otton, S., et al.: Br. J. Clin. Pharmacol., 30, 751 (1990), Fujita, S., et al.: J. Pharmacol. Exp. Ther., 264, 226 (1993), Bichara, N., et al.: Drug Metab. Dispos., 24, 112 (1996), Tasaki, T., et al.: J. Biochem., 123, 162 (1998),<br></p>Fórmula:C16H21NO3·HClForma y color:NeatPeso molecular:311.804Efavirenz Amino Alcohol Ethyl Carbamate
CAS:Producto controlado<p>Applications Efavirenz Amino Alcohol Ethyl Carbamate is used in the synthesis of Efavirenz (E425000), a potent non-nucleoside HIV-1 reverse transcriptase inhibitor. Antiviral<br>References Young, S.D., et al.: Antimicrob. Ag. Chemother., 39, 2602 (1995)<br></p>Fórmula:C16H15ClF3NO3Forma y color:NeatPeso molecular:361.743-(3-Chloropropyl)-7,8-dimethoxy-1H-3-benzazepin-2(3H)-one
CAS:Producto controlado<p>Applications 3-(3-Chloropropyl)-7,8-dimethoxy-1H-3-benzazepin-2(3H)-one is a reactant used in the synthesis of Zatebradine analogues as potential blockers od hyperpolarization-activated current.<br>References Romanelli, M. et al.: Bioorg. med. CHem., 13, 1211 (2005);<br></p>Fórmula:C15H18ClNO3Forma y color:NeatPeso molecular:295.76Fenspiride N-Oxide
CAS:Producto controlado<p>Stability Hygroscopic<br>Applications Fenspiride N-Oxide is an impurity of Fenspiride (F265000),an bronchodilator with anti-inflammatory properties. Inhibits mucus secretion and reduces the release of tachykinins at a prejunctional level by its anti-muscarinic action.<br>References Arnone, A., et al.: Tetrahedron., 54, 7831 (1998);<br></p>Fórmula:C15H20N2O3Forma y color:NeatPeso molecular:276.33Homopiperazine
CAS:Producto controlado<p>Applications Homopiperazine acts as a corrosion inhibitor for iron. It has also been used in the preparation of potent H3 receptor antagonists for use as treatments for neurodegenerative conditions such as Alzheimer’s disease.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Granese, S. et al.: Corrosion., 44, 322 (1988); Pippel, D. et al.: Org. Proc. Res. Devel., 15, 638 (2011);<br></p>Fórmula:C5H12N2Forma y color:NeatPeso molecular:100.16Thiazol-5-ylmethyl ((2R,5R)-5-Amino-1,6-diphenylhexan-2-yl)carbamate Hydrochloride
CAS:Producto controlado<p>Applications Thiazol-5-ylmethyl ((2R,5R)-5-Amino-1,6-diphenylhexan-2-yl)carbamate Hydrochloride is an impurity of Cobicistat (C633150), a HIV protease inhibitor that has been coadministered with low-dose ritonavir (R535000) as a pharmacoenhancer.<br>References Von, H., Exp. Rev. Clin. Pharmacol., 5, 557 (2012); Lepist, E.I., et al.: Antimicrob. Agent. Chemother., 56, 5409 (2012); Orr, S.T.M., et al.: J. Med. Chem., 55, 4896 (2012)<br></p>Fórmula:C23H27N3O2S·HClForma y color:NeatPeso molecular:446.0Loratadine-d5 (ethyl-d5)
CAS:Producto controlado<p>Applications Loratadine-d5 (ethyl-d5) (CAS# 1398065-63-8) is a useful isotopically labeled research compound.<br></p>Fórmula:C22D5H18ClN2O2Forma y color:NeatPeso molecular:387.92N-Nitrosomorpholine-13C4
CAS:Producto controladoFórmula:C4H8N2O2Forma y color:NeatPeso molecular:120.092-Bromomethyl-6-nitrobenzoic Acid Methyl Ester
CAS:Producto controladoFórmula:C9H8BrNO4Forma y color:Light YellowPeso molecular:274.07Sitagliptin N-Sulfate Sodium Salt
CAS:Producto controlado<p>Applications A metabolite of Sitagliptin.<br>References Beconi, M.G. , et al.: Drug Metab. Dispos., 35, 525 (2007),<br></p>Fórmula:C16H15F6NaN5O4SForma y color:NeatPeso molecular:509.36(D,L)-erythro-α-Phenyl-2-piperidineacetamide
CAS:Producto controlado<p>Stability Hygroscopic<br>Applications Intermediate in the preparation of D-threo-Methylphenidate (Ritalin)<br></p>Fórmula:C13H18N2OForma y color:NeatPeso molecular:218.29(Z)-4-Hydroxy Tamoxifen O-β-D-Glucuronide (~90%)
CAS:Producto controlado<p>Applications (Z)-4-Hydroxy Tamoxifen O-β-D-Glucuronide is an active metabolite of Tamoxifen (T006000).<br>References Ogura, K. et al.: Biochem. Pharmacol., 71, 1358 (2006); Nishiyama, T. et al.: Biochem. Pharmacol., 63, 1817 (2002); McCague, R. et al.: Biochem. Pharmacol., 39, 1459 (1990);<br></p>Fórmula:C32H37NO8Pureza:~90%Forma y color:NeatPeso molecular:563.645-(Ethoxycarbonyl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3-pyridinecarboxylic Acid
CAS:Producto controladoFórmula:C17H18N2O6Forma y color:NeatPeso molecular:346.331-(4-(4-(tert-Butyl)phenyl)-4-hydroxybutyl)piperidine-4-carboxylic Acid
Producto controladoFórmula:C20H31NO3Forma y color:NeatPeso molecular:333.4652-(Bromomethyl)-3-nitrobenzoic Acid Methyl Ester
CAS:Producto controlado<p>Applications 2-(Bromomethyl)-3-nitrobenzoic Acid Methyl Ester (cas# 98475-07-1) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>Fórmula:C9H8BrNO4Forma y color:Off-White To Light YellowPeso molecular:274.07N-Cyano-N’,N”-bis[2-[[(5-methyl-1H-imidazol-4-yl)methyl]thio]ethyl]guanidine
CAS:Producto controlado<p>Applications N-Cyano-N’,N”-bis[2-[[(5-methyl-1H-imidazol-4-yl)methyl]thio]ethyl]guanidine is an impurity of Cimetidine (C441650)<br>References Ellis, D. R., et al.: J. Chromatogr. A, 808, 269-275 (1998)<br></p>Fórmula:C16H24N8S2Forma y color:NeatPeso molecular:392.54Risperidone 9-Ethylidenecarboxylate Hydrochloride
Producto controlado<p>Applications Risperidone 9-Ethylidenecarboxylate Hydrochloride, is the derivative of Risperidone (R525000), which is combined serotonin (5-HT2) and dopamine (D2) receptor antagonist, used for the treatment of schizophrenia, bipolar disorder and behavior problems in people with autism.<br>References Tiberghien, F., et al.: Anticancer Drugs, 7, 568 (1996), Kansy, M., et al.: J. Med. Chem., 41, 1007 (1998), Kerns, E., et al.: J. Pharm. Sci., 90, 1838 (2001), Kerr, K., et al.: J. Biol. Chem., 276, 8657 (2001), Doran, A., et al.: Drug Metab. Dispos., 33, 165 (2005),<br></p>Fórmula:C25H27FN4O4Forma y color:NeatPeso molecular:466.5036462’-Des(1-hydroxy-1-methylethyl)-2’-methycarboxy Montelukast Hydrochloride
CAS:Producto controlado<p>Applications 2’-Des(1-hydroxy-1-methylethyl)-2’-methycarboxy Montelukast Hydrochloride is an impurity of Montelukast (M568000), a selective leukotriene D4-receptor antagonist.<br>References Kumar, I.V. et al.: Asian J. Chem., 23, 4536 (2011)<br></p>Fórmula:C34H33Cl2NO4SForma y color:NeatPeso molecular:622.6N-De[2-(methylsulfonyl)ethyl] Lapatinib
CAS:Producto controlado<p>Applications A reactive metabolite of Lapatinib (L175800) which is associated with various drug toxicities. Lapatinib is metabolized mainly by P450 3A4 to form O- and N-dealkylated metabolites.<br>References He, K., et al.: Chem. Res. Toxicol., 11, 252 (1998), Rusnuk, D., et al.: Cancer Res., 61, 7196 (2001), Li, X., et al.: Drug Metab. Dispos., 37, 1242 (2009),<br></p>Fórmula:C26H20ClFN4O2Forma y color:NeatPeso molecular:474.915'-Hydroxyphenyl Carvedilol-d5
CAS:Producto controlado<p>Applications A Labelled metabolite of Carvedilol which is a multiple-action, neurohormonal antagonist that is used in the treatment of hypertension.<br>References Schaefer, W.H., et al.: Drug Metab. Dispos., 26, 958 (1998).<br></p>Fórmula:C24H21D5N2O5Forma y color:NeatPeso molecular:427.54-Desmethoxypropoxyl-4-chloro Rabeprazole Sulfide
CAS:Producto controlado<p>Applications A process impurity of Rabeprazole (R070500).<br>References Pingili, R.R., et al.: Pharmazie, 60, 814 (2005),<br></p>Fórmula:C14H12ClN3SForma y color:NeatPeso molecular:289.78(E/Z)-Chlorprothixene-d6 Hydrochloride(Mixture)
CAS:Producto controlado<p>Applications Labelled cis/trans-Chlorprothixene (C424850). Antipsychotic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Rudy, B.C., et al.: Anal. Profiles Drug Subs., 2, 63 (1973), Bagli, M., et al.: Arzneim.-Forsch., 46, 247 (1996),<br></p>Fórmula:C18H13D6Cl2NSForma y color:NeatPeso molecular:358.363-Isoniazid
CAS:Producto controlado<p>Applications An impurity of Isoniazid (I821450), potent antitubercular agent against M. tuberculosis.<br>References Brewer, G.A., et al.: Anal. Profiles. Drug. Subs., 6, 183 (1977), Andrade, C., et al.: Lett. Drug. Des. Discov., 5, 377 (2008)<br></p>Fórmula:C6H7N3OForma y color:Off White PowderPeso molecular:137.14Ambrisentan-d10
CAS:Producto controlado<p>Applications Ambrisentan-d10, is the labeled analogue of Ambrisentan (A575860), a nonpeptide endothelin ETA receptor antagonist. Antihypertensive.<br>References Riechers, H., et al.: J. Med. Chem., 39, 2123 (1996), Billman, G.E., et al.: Curr. Opin. Invest. Drugs, 3, 1483 (2002), Vatter, H., et al.: Clin. Neuropharmacol., 26, 73 (2003),<br></p>Fórmula:C22H12D10N2O4Forma y color:NeatPeso molecular:388.48(S)-Hydroxy Timolol
CAS:Producto controlado<p>Applications (S)-(-)-Hydroxy Timolol is a metabolite of the non-selective beta-adrenergic receptor blocker, Timolol (T443710).<br>References Volotinen, M. et al.: Basic Clin. Pharmacol. Toxicol., 106, 302 (2010);<br></p>Fórmula:C13H24N4O4SForma y color:NeatPeso molecular:332.42Fingolimod Stearoate Amide
CAS:Producto controlado<p>Applications Fingolimod Stearoate Amide is an impurity of Fingolimod (F805000, HCl salt), a novel immune modulator that prolongs allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs.<br>References Brinkmann, V., et al.: Transplantation, 72, 764 (2001), Brinkmann, et al.: J. Biol. Chem., 277, 24, 21453 (2002), Mtaloubian, M., et al.: Nature, 427, 355 (2004),<br></p>Fórmula:C37H67NO3Forma y color:NeatPeso molecular:573.93Vilazodone Carboxylic Acid
CAS:Producto controlado<p>Stability Hygroscopic<br>Applications Vilazodone Carboxylic Acid is the carboxylic acid impurity and an intermediate in the preparation of the antidepressant Vilazodone (V265000).<br>References Heinrich, T. et al.: J. Med. Chem., 47, 4684 (2004); Hu, B. et al.: Org. Proc. Res. Dev., 16, 1552 (2012);<br></p>Fórmula:C26H26N4O3Forma y color:NeatPeso molecular:442.51N-Aminocarbonyl Felbamate
CAS:Producto controlado<p>Applications N-Aminocarbonyl Felbamate is an impurity of Felbamate (F231000), an antiepileptic, structurally similar to meprobamate.<br></p>Fórmula:C12H15N3O5Forma y color:NeatPeso molecular:281.26Olanzapine-d3 (1 mg/ml in Acetonitrile)
CAS:Producto controladoFórmula:C172H3H17N4SForma y color:ColourlessPeso molecular:315.45Benzo[b]thien-2-yl Ketone (Zileuton Impurity)
CAS:Producto controlado<p>Applications Benzo[b]thien-2-yl ketone is an impurity of Zileuton (Z420000), an inhibitor of 5-lipoxygenase that is used to treat patients with asthma. Benzo[b]thien-2-yl ketone is used as a reagent to synthesize Bis(1H-2-indolyl)methanone, compounds that inhibit the activity of growth factor receptor kinase. Benzo[b]thien-2-yl ketone is also used as a reagent to prepare annulated oligothiophenes, compounds that are used in organic light-emitting devides (OLEDs).<br>References Israel, E., et al.: JAMA, 275, 931 (1996); Mahboobi, S., et al.: J. Med. Chem., 45, 1002 (2002); Mitschke, U. & Bäuerle, P.: J. Chem. Soc. Perk. Trans., 1, 740 (2001); Nenajdenko, V., et al.: Russ. Chem. Bull., 61, 1456 (2012)<br></p>Fórmula:C17H10OS2Forma y color:NeatPeso molecular:294.39N1-Methyl-N2-2-pyridinylethanediamide
CAS:Producto controladoFórmula:C8H9N3O2Forma y color:NeatPeso molecular:179.18Pazufloxacin Mesylate
CAS:Producto controlado<p>Applications A fluorinated quinolone antibiotic. Antibacterial.<br>References Fukuoka,Y., et al.: Antimicrob. Ag. Chemother., 37, 384 (1993), Todo, Y., et al.: Chem. Pharm. Bull., 42, 2569 (1994)<br></p>Fórmula:C16H15FN2O4·CH4O3SForma y color:NeatPeso molecular:414.41Carboxyamidotriazole
CAS:Producto controlado<p>Applications Carboxyamidotriazole is an orally active calcium channel blocker. Carboxyamidotriazole also exhibits inhibition of pro-inflammatory cytokines in tumor associated macrophages as potential anti-cancer mechanism.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ju, R., et al.: Euro. J. Cancer., 48, 1085 (2012); Corrado, C., et al.: Cancer. lett., 300, 205 (2011);<br></p>Fórmula:C17H12Cl3N5O2Forma y color:NeatPeso molecular:424.674-[[3-[2-(3-Chlorophenyl)ethyl]-2-pyridinyl]carbonyl]-1-piperidinecarboxylic AcidEthyl Ester
CAS:Producto controlado<p>Applications Loratadine intermediate, as antiallergic agent.<br></p>Fórmula:C22H25ClN2O3Forma y color:NeatPeso molecular:400.901-(4-Carboxybutyl)-3,7-dimethylxanthine
CAS:Producto controladoFórmula:C12H16N4O4Forma y color:White To Off-WhitePeso molecular:280.285-Ethenyl-2-pyrrolidinone
CAS:Producto controlado<p>Impurity Vigabatrin USP Related Compound A<br>Applications Vigabatrin (V253000) impurity. Vigabatrin USP Related Compound A.<br>References Durham, S. et al.: Drug Metab. Dispos. 21, 480 (1993).<br></p>Fórmula:C6H9NOForma y color:Colourless To BrownPeso molecular:111.14Manidipine
CAS:Producto controlado<p>Applications A dihydropyridine calcium channel blocker. Antihypertensive.<br>References Meguro, K., et al.: Chem. Pharm. Bull., 33, 3787 (1985), Mizuno, K., et al.: Curr. Ther. Res., 52, 248 (1992)<br></p>Fórmula:C35H38N4O6Forma y color:Off White PowderPeso molecular:610.70Des-6-[4-(2-hydroxyethyl)-1-piperazinyl]-6-chloro Dasatinib
CAS:Producto controlado<p>Applications Intermediate in the preparation of Dasatinib metabolite, used in the treatment of cancers and immune diseases. It is a COVID19-related research product.<br></p>Fórmula:C16H13Cl2N5O2SForma y color:NeatPeso molecular:410.28Cibenzoline
CAS:Producto controlado<p>Applications Cibenzoline acts as a highly active class I antiarrhythmic agent.<br>References Xie, C. et al.: Handbook. Metab. Pathway. Xenobio., 3, 1110 (2014);<br></p>Fórmula:C18H18N2Forma y color:NeatPeso molecular:262.35Brivaracetam-d7 (Mixture of Diastereomers)
Producto controlado<p>Applications Brivaracetam-d7 (Mixture of Diastereomers), is a mixture of 2 diastereomers of Brivaracetam-d7 (B677647), and a labeled analogue of Brivaracetam (B677645), 4-n-propyl analog of levetiracetam (L331500), and a racetam derivative with anticonvulsant properties.<br>References Rosenstiel, P., et al.:Neurotherapeutics, 4 (1), 84 (2007); Malawska, B., et al.:, Curr. Opin. Investig. Drugs, 6(7), 740 (2005);<br></p>Fórmula:C11H13D7N2O2Forma y color:NeatPeso molecular:219.33Imatinib (Piperidine)-1-oxide
CAS:Producto controlado<p>Stability Hygroscopic<br>Applications Imatinib (Piperidine)-1-oxide is an impurity of Imatinib (Gleevec) (G407000). Imatinib impurity C. It is a COVID19-related research product.<br>References Taruns, C., et al.: Bioorg. Chem., 16, 38 (1988), Cohen, M., et al.: Clin. Cancer Res., 8, 935 (2002), Gschwind, H., et al.: Drug Metab. Dispos., 33, 1503 (2005), Peng, B., et al.: Clin. Pharmacokinet., 44, 879 (2005),<br></p>Fórmula:C29H31N7O2Forma y color:Light Yellow To YellowPeso molecular:509.60Benperidol
CAS:<p>Applications Benperidol is an antipsychotic which can be used for the treatment of schizophrenia, but is primarily used to control antisocial hypersexual behaviour.<br>References Bobon, J., et al.: Acta Neurol Belg, 63, 839-43 (1963);<br></p>Fórmula:C22H24FN3O2Forma y color:White To Off-WhitePeso molecular:381.442-Methylthieno[2,3-d]isothiazol-3(2H)-one 1,1-Dioxide
CAS:Producto controladoFórmula:C6H5NO3S2Forma y color:NeatPeso molecular:203.24(4S3-[(2R,5S)-5-(4-Fluorophenyl)-2-[(S)-[(4-fluorophenyl)amino][4-[(trimethylsilyl)oxy]phenyl]methyl]-1-oxo-5-[(trimethylsilyl)oxy]pentyl]-4-phenyl-2-oxazolidinone
CAS:Producto controlado<p>Applications (4S3-[(2R,5S)-5-(4-Fluorophenyl)-2-[(S)-[(4-fluorophenyl)amino][4-[(trimethylsilyl)oxy]phenyl]methyl]-1-oxo-5-[(trimethylsilyl)oxy]pentyl]-4-phenyl-2-oxazolidinone is used in the synthesis of Ezetimibe (E975000), an antihyperlipoproteinemic; a cholesterol absorption inhibitor.<br>References Bankowski, K., et. al.: Przemysl Chemiczny, 91, 289 (2012); van Heek, M., at al.: J. Pharmacol. Exp. Ther., 283, 157 (1997); van Heek, M., at al.: Brit. J. Pharmacol., 129, 1748 (2000)<br></p>Fórmula:C39H46F2N2O5Si2Forma y color:NeatPeso molecular:716.9612-Amino-3-benzyloxypyridine
CAS:Producto controlado<p>Applications 2-Amino-3-benzyloxypyridine is used in preparation of pyridinyl/pyridazinyloxymethyl substituted Raf kinase inhibitors.<br>References Jen, T., et al.: J. Med. Chem., 20, 1258 (1977), Chung, D., et al.: Antican. Res., 11, 1373 (1991),<br></p>Fórmula:C12H12N2OForma y color:NeatPeso molecular:200.245-Amino-4-(4-nitro-1-oxoisoindolin-2-yl)-5-oxopentanoic Acid
CAS:Producto controladoFórmula:C13H13N3O6Forma y color:Off-WhitePeso molecular:307.259N-[(2Z)-Piperazin-2-ylidene]-2,2,2-trifluoroacetohydrazide
CAS:Producto controlado<p>Applications Sitagliptin intermediate.<br>References Sarges, R, et al.: J. Med. Chem., 33, 2240 (1990),<br></p>Fórmula:C6H9F3N4OForma y color:NeatPeso molecular:210.16(3S)-1-[2-(3-Ethenyl-4-hydroxyphenyl)ethyl]-α,α-diphenyl-3-pyrrolidineacetamide
CAS:Producto controladoFórmula:C28H30N2O2Forma y color:NeatPeso molecular:426.554-Isobutylamino-3-aminoquinoline
CAS:Producto controlado<p>Applications 4-Isobutylamino-3-aminoquinoline is a pharmacologically active compound related to Imiquimod (I475000), an immune response modifier. It stimulates the production of Interferon-a.<br>References Megyeri, K., et al.: Mol. Cell Biol., 15, 2207, (1995), Witt, P.L., et al.: Cancer Res., 53, 5176 (1993), Edwards, L., et al.: Arch. Dermatol., 134, 25 (1998); Gerster, J. et al.: J. Med. Chem., 48, 3481 (2005);<br></p>Fórmula:C13H17N3Forma y color:NeatPeso molecular:215.29Lornoxicam-d4
CAS:Producto controlado<p>Applications Labelled Lornoxicam. Cyclooxygenase inhibitor; structurally similar to tenoxicam. Anti-inflammatory; analgesic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ankier, S.I., et al.: Postgrad. Med. J., 64, 752 (1988), Tricerri, M., et al.: Chem. Phys. Lipids, 71, 61 (1994), Santos, N., et al.: Biochemistry, 37, 8674 (1998), Pellicano, A., et al.: Infect. Immun., 75, 1738 (2007),<br></p>Fórmula:C132H4H6ClN3O4S2Forma y color:NeatPeso molecular:375.84Eltenac-13C,d3
CAS:Producto controlado<p>Applications Labelled Eltenac (E507000). A nonsteroidal anti-inflammatory drug.<br>References Allen, A., et al.: Gut, 21, 249 (1980), Tobin, T., et al.: J. Vet. Pharmacol. Therap., 9, 1 (1986),<br></p>Fórmula:CC11H7Cl2D2NO2SForma y color:NeatPeso molecular:302.18N-Methyl-2-[[3-[(1Z)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]thio]benzamide
CAS:Producto controlado<p>Applications N-Methyl-2-[[3-[(1Z)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]thio]benzamide is an impurity of Axitinib (A794650), a tyrosine kinase inhibitor. Axitinib is used in cancer therapy.<br>References Wasser, K., et al.: Eur. Radiol., 13, 80 (2003), Park, J., et al.: Clin. Cancer Res., 8, 1172 (2002), Bergers, G., et al.: J. Clin. Invest., 111, 1287 (2003),<br></p>Fórmula:C22H18N4OSForma y color:NeatPeso molecular:386.4695Argatroban
CAS:Producto controlado<p>Applications Synthetic thrombin inhibitor. Antithrombotic.<br>References Abiko, Y., et al.: Thromb. Res., 24, 285 (1981), Kikumoto, R., et al.: Biochemistry, 23, 85 (1984),<br></p>Fórmula:C23H36N6O5SForma y color:White PowderPeso molecular:508.63N-Nitroso-desethyl-Hydroxychloroquine
Producto controladoFórmula:C16H21ClN4O3Forma y color:NeatPeso molecular:336.817N-tert-Butyl-3-isopropyl-5-oxo-4,5-dihydro-1H-1,2,4-triazole-1-carboxamide
CAS:Producto controlado<p>Applications N-tert-Butyl-3-isopropyl-5-oxo-4,5-dihydro-1H-1,2,4-triazole-1-carboxamide is a metabolite of Amicarbazone (A605040); a triazolinone herbicide with a broad spectrum of weed control.<br>References Dayan, F., et al.: Weed Science, 57, 579 (2009); Elmore, M., et al.: Weed Technol., 27, 596 (2013); Dong, M., et al.: J. Sep. Sci., 38, 2245 (2015)<br></p>Fórmula:C10H18N4O2Forma y color:White To Off-WhitePeso molecular:226.28Benzoin
CAS:Producto controlado<p>Applications Benzoin has been used as a catalyst in photoinitiation.<br>References Voll, D., et. al.: Macromolecules, 44, 2542 (2011)<br></p>Fórmula:C14H12O2Forma y color:Off-WhitePeso molecular:212.24Desacetyl Diltiazem-d3
CAS:Producto controlado<p>Applications A labelled metabolite of Diltiazem (D460620).<br>References Shallcross, H., et al.: Br. Med. J., 295, 1236 (1987), Yeung, P.K.F., et al.: Drug Metab. Dispos., 18, 1055 (1990), Cashman, J.R., et al.: J. Med. Chem., 34,2049 (1991),<br></p>Fórmula:C20H21D3N2O3SForma y color:NeatPeso molecular:375.5N-Desethyl N-Methyl Rivastigmine
CAS:Producto controlado<p>Impurity Rivastigmine EP Impurity B<br>Applications N-Desethyl N-Methyl Rivastigmine (Rivastigmine EP Impurity B) is an impurity of Rivastigmine (R541000), a brain selective acetylcholinesterase inhibitor. Nootropic.<br>References Rosler, M., et al.: Brit. Med. J., 318, 633 (1999), Enz, A., et al.: Prog. Brain Res., 98, 431 (1993),<br></p>Fórmula:C13H20N2O2Forma y color:NeatPeso molecular:236.32Oxo-MDV 3100 (Oxo-enzalutamide)
CAS:Producto controlado<p>Applications Oxo-MDV 3100 (Oxo-enzalutamide) is an impurity of Enzalutamide (M199800), which is an androgen-receptor antagonist that blocks androgens from binding to the androgen receptor and prevents nuclear translocation and co-activator recruitment of the ligand-receptor complex. Enzalutamide has been shown to induce tumor cell apoptosis, and is used for the treatment of castration-resistant prostate cancer.<br>References Scher, H.I. et al.: Lancet, 375, 1437 (2010); Bellmunt, J. et al.: Ther. Adv. Med. Oncol., 2, 189 (2010); Ryan, C.J. et al.: J. Clin. Oncol., 29, 3651 (2011); Ma, X., et al.: J. Pharm. Biomed. Anal., 131, 436 (2016);<br></p>Fórmula:C21H16F4N4O3Forma y color:NeatPeso molecular:448.37Riociguat Nitroso Impurity 1
Producto controladoFórmula:C18H16FN9OForma y color:NeatPeso molecular:393.15rac Viloxazine Hydrochloride
CAS:Producto controladoFórmula:C13H19NO3·ClHForma y color:WhitePeso molecular:273.765-(4'-Methyl-2-biphenyl)tetrazole-d4
CAS:Producto controlado<p>Applications Labelled Valsartan (V095750) impurity.<br>References Thai, H., et al.: J. Cardiovasc. Pharmacol., 50, 703 (2007), Lukas, J., et al.: Science, 313, 662 (2006),<br></p>Fórmula:C14H8D4N4Forma y color:Off-WhitePeso molecular:240.301Tianeptine Metabolite MC5-d4 Sodium Salt
CAS:Producto controlado<p>Applications Labelled, primary metabolite of Tianeptine.<br>References Dresse, A., et al.: J. Clin. Pharmacol., 28, 1115 (1988), Grislain, L., et al.: Drug Metab. Dispos., 18, 804 (1990),<br></p>Fórmula:C19H16D4ClN2NaO4SForma y color:NeatPeso molecular:434.914-Hydroxy Phenylbutazone
CAS:<p>Applications Impurity in the production of Phenylbutazone (P319570)<br>References Fricoteaux, R., et al.: J. Pharm. Biomed. Anal., 7, 1585 (1989), Segrestaa, J., et al.: Chem. Pharm. Bull., 50, 744 (2002),<br></p>Fórmula:C19H20N2O3Forma y color:White To Off-WhitePeso molecular:324.37rac O-Desmethyl Naproxen-d3
CAS:Producto controladoFórmula:C13D3H9O3Forma y color:Dark RedPeso molecular:219.25rac-Bromo-Descyanobicalutamide
Producto controlado<p>Applications Descyano-Bromo-Bicalutamide is related to Bicalutamide(B382000). A non-steroidal androgen receptor antagonist that binds the androgen receptor and prevents its activation<br>References Tucker, H., et al.: J. Med. Chem., 31, 954 (1988), Cockshott, I.D., et al.: Eur. Urol., 18, Suppl. 3, 10 (1990)<br></p>Fórmula:C17H14BrF4NO4SForma y color:NeatPeso molecular:484.26N-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-N-methylnitrous amide
CAS:Producto controladoFórmula:C12H14N4O2Forma y color:NeatPeso molecular:246.27Pamapimod
CAS:Producto controlado<p>Applications A selective inhibitor of the α-isoform of p38 MAP kinase. It is used in in treatment of patient with rheumatoid arthritis. Pamapimod was tolerable but not effective as Methotrexate.<br>References Guan, Z., et al.: J. Biol. Chem., 273, 12901 (1998), Lee, J., et al.: Pharmacol. Ther., 82, 389 (1999), Korb, A., et al.: Arthritis Rheum., 54, 2745 (2006),<br></p>Fórmula:C19H20F2N4O4Forma y color:WhitePeso molecular:406.38Dimenhydrinate
CAS:Producto controlado<p>Stability Hygroscopic<br>Applications An antihistamine with antiemetic properties used to prevent nausea and motion sicknes composed of two drugs 8-Chlorotheophylline (C411440) and Diphenhydramine (D486900).<br>References Sibel, K. et al.: Arzneim.-Forsch. , 52, 529 (2002); Pytel, J. et al.: Clin. Therap., 29, 84 (2007); Scholtz, A.W. et al.: Clin. Therap., 26, 866 (2004);<br></p>Fórmula:C17H21NO·C7H7ClN4O2Forma y color:NeatPeso molecular:469.96Indomethacin Acyl-β-D-glucuronide (>90%)
CAS:Producto controlado<p>Applications Indomethacin Acyl-β-D-glucuronide is a metabolite of Indomethacin (I641000). Acyl glucuronides have been implicated in the toxicity of many xenobiotics and marketed drugs.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Abid, A., et al.: Biochem. Pharmacol., 50, 557 (1995), Gamage, N., et al.: Toxicol. Sci., 90, 5 (2006), Cerveny, L., et al.: Drug Metab. Dispos., 35, 1032 (2007), Hayeshi, R., et al.: Eur. J. Pharm. Sci., 35, 383 (2008),<br></p>Fórmula:C25H24ClNO10Forma y color:NeatPeso molecular:533.9110-Methoxy-5H-dibenz[b,f]azepine-5-carbonyl chloride
CAS:Producto controladoFórmula:C16H12ClNO2Forma y color:NeatPeso molecular:286.00Ethyl 4-(8-chloro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)piperidine-1-carboxylate
CAS:Producto controlado<p>Applications Ethyl 4-(8-chloro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)piperidine-1-carboxylate is an impurity of loratadine (L469575), which is a nonsedating-type histamine H1-receptor.<br>References Bruttmann, G., et al.: J. Allergy Clin. Immunol., 83, 411 (1989), Haria, M., et al.: Drugs, 48, 617 (1994)<br></p>Fórmula:C22H21ClN2O2Forma y color:NeatPeso molecular:380.87Valdecoxib Sulfonic Acid
CAS:Producto controlado<p>Applications Valdecoxib Sulfonic Acid is a metabolite of the potent and specific inhibitor of cyclooxygenase-2, Valdecoxib (V090000).<br>References Zhang, J.I. et al.: Drug Metab. Dispos., 31, 491 (2003); Yuan, J.J. et al.: Drug Metab. Dispos., 30, 1013 (2002);<br></p>Fórmula:C16H13NO4SForma y color:White To Off-WhitePeso molecular:315.342-epi-Darunavir
CAS:<p>Applications 2-epi-Darunavir is a stereoisomer to Darunavir (D193500), a second generation HIV-1-protease inhibitor; structurally similar to amprenavir. Antiviral. It is a COVID19-related research product.<br>References Rao, R.N., et. al.: J. Sep. Sci., 35, 2671 (2012); Koh, Y., et al.: Antimicrob. Agents Chemother., 47, 3123 (2003); Arasteh, K., et al.: AIDS, 19, 943 (2005); Surleraux, D.L.N.G., et al.: J. Med. Chem., 48, 1813 (2005)<br></p>Fórmula:C27H37N3O7SForma y color:NeatPeso molecular:547.662-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one
CAS:Producto controlado<p>Applications 2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one, is an impurity of Eltrombopag (E508000), which is agonist of the Thrombopoietin (Tpo) receptor, used as treatment for thrombocytopenia.<br>References Bussel, J., et al.: New Eng. J. Med., 357, 2237 (2007), Marsilje, T., et al.: Bioorg. Med. Chem. Lett., 18, 5259 (2008), Alper, P., et al.: Bioorg. Med. Chem. Lett., 18, 5255 (2008),<br></p>Fórmula:C12H14N2OForma y color:NeatPeso molecular:202.25(R)-Desmethyl Citalopram Hydrochloride
CAS:Fórmula:C19H19FN2O·ClHForma y color:NeatPeso molecular:346.834-Hydroxy-2-methyl- 1,1-dioxide-2H-thieno[2,3-e]-1,2-thiazine-3-carboxamide
CAS:Producto controladoFórmula:C8H8N2O4S2Forma y color:NeatPeso molecular:260.293-Bromo-2-methylpropionic Acid
CAS:<p>Impurity Captopril EP Impurity D<br>Stability Hygroscopic<br>Applications 3-Bromo-2-methylpropionic Acid (Captopril EP Impurity D) is used in the preparation of captopril selenium analogs as antioxidants and ACE inhibitors used as antihypertensive drugs.<br>References Bhuyan, B. et al.: Org. Biomol. Chem., 9, 1356 (2011);<br></p>Fórmula:C4H7BrO2Forma y color:Colourless LiquidPeso molecular:167.00Everolimus NHS-carbonate (>85%)
Producto controlado<p>Applications Everolimus NHS-carbonate is a derivative of Everolimus (E945400), a macrolide immunosuppressant.<br></p>Fórmula:C58H86N2O18Pureza:>85%Forma y color:NeatPeso molecular:1099.3064-Hydroxy Flecainide
CAS:Producto controlado<p>Applications 4-Hydroxy Flecainide is an analogue of Flecainide (F390000).<br>References Blom, Y., et al.: J. Chromatogr., 653, 138 (1993),<br></p>Fórmula:C17H20F6N2O4Forma y color:NeatPeso molecular:430.34Verapamil Ethyl Methanethiosulfonate, Bromide
CAS:Producto controlado<p>Applications An analog of Verapamil. P Glycoprotein drug binding domain verapamil methanethiosulfonate. Useful for mapping the pore region of L-type calcium channels and Kv1.3 potassium channels.<br>References Loo, T., et al.: J. Biol. Chem., 270, 843 (1995), Sharom, F., et al.: J. Membr. Biol., 160, 161 (1997), Kim, R., et al.: J. Clin. Invest., 101, 289 (1998), Lee, C., et al.: Biochemistry., 37, 3594 (1998),<br></p>Fórmula:C30H45N2O6S2·BrForma y color:NeatPeso molecular:673.72rac-Rupatadine Pyridinium Fumarate Adduct Inner
CAS:Producto controladoFórmula:C30H30ClN3O4Forma y color:NeatPeso molecular:532.03Dinaciclib
CAS:Producto controlado<p>Stability Hygroscopic<br>Applications Dinaciclib is a potent and selective inhibitor of cyclin-dependent kinases which is undergoing development as oncology therapeutics.<br>References Paruch, K., et al.: ACS. Med. Chem. Lett., 1, 204 (2010); Zhang, Da., et al.: Cancer. Chemotherap. Pharmacol., 70, 891 (2012); Chen, S., et al.: Cancer. Res., 72, 4225 (2012);<br></p>Fórmula:C21H28N6O2Forma y color:NeatPeso molecular:396.49Dutasteride-13C6
CAS:Producto controlado<p>Applications Labelled Dutasteride (D735000). Dutasteride is a dual inhibitor of 5α-reductase isoenzymes type 1 and 2; structurally related to Finasteride (F342000). Dutasteride is used in the treatment of benign prostatic hyperplasia.<br>References Bakshi, R.K., et al.: J. Med. Chem., 38, 3189 (1995), Gisleskog, P.O., et al.: Brit. J. Clin. Pharmacol., 47, 53 (1999), Djavan, B., et al.: Expert Opin. Pharmacother., 6, 311 (2005),<br></p>Fórmula:C2113C6H30F6N2O2Forma y color:NeatPeso molecular:534.494’-Fluoroacetophenone
CAS:<p>Applications 4’-Fluoroacetophenone is an intermediate used for the synthetic preparation of various pharmaceutical good and agricultural products.<br>References Xiao, Z.J., et al.: Chem. Eng. Sci., 84, 695 (2012); Vitale, P., et al.: Tetrahedron., 22, 1985 (2011); Kawano, S., et al.: Biosci. Biotech. Biochem., 75, 1055 (2011);<br></p>Fórmula:C8H7FOForma y color:NeatPeso molecular:138.143-(2-Chloroethyl)-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one
CAS:<p>Applications An intermediate in the synthesis of Risperidone (R525000), which is a combined serotonin (5-HT2) and dopamine (D2) receptor antagonist.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Brown, T., et al.: J. Med. Chem., 33, 527 (1990), Yapi, A., et al.: Chem. Pharm. Bull., 48, 1886 (2000), Yapi, A., et al.: Arch. Pharm., 339, 201 (2006); Jannssen, P.A.J., et al.: J. Pharmacol. Exp. Ther., 244, 685 (1988); Gelders, Y.G., et al.: Pharmacopsychiatry, 23, 206 (1990); Green, B.: Curr. Med. Res. Opin., 16, 57 (2000);<br></p>Fórmula:C11H11ClN2OForma y color:NeatPeso molecular:222.67Ethionamide Sulfoxide-D3
CAS:Producto controladoFórmula:C8D3H7N2OSForma y color:NeatPeso molecular:185.262,2'-[[[4-(3-Oxo-4-morpholinyl)phenyl]imino]bis[(2R)-2-hydroxy-3,1-propanediyl]]bis[1H-isoindole-1,3(2H)-dione]
CAS:Producto controlado<p>Stability Hygroscopic<br>Applications 2,2'-[[[4-(3-Oxo-4-morpholinyl)phenyl]imino]bis[(2R)-2-hydroxy-3,1-propanediyl]]bis[1H-isoindole-1,3(2H)-dione] is an impurity of Rivaroxaban (R538000), a novel antithrombotic agent. A highly potent and selective, direct FXa inhibitor.<br>References Ansell, J., et al.: Drugs, 64, 1 (2004), Eriksson, B., et al.: J. Thromb. Haemost., 3, 103 (2005), Kubitza, D., et al.: Clin. Pharmacol. Ther., 78, 412 (2005),<br></p>Fórmula:C32H30N4O8Forma y color:NeatPeso molecular:598.63-[2-[4-(6-Fluoro-2-benzoxazolyl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one (Risperidone Impurity)
CAS:Producto controladoFórmula:C23H27FN4O2Forma y color:NeatPeso molecular:410.48Diphenhydramine-d6 N-Oxide
CAS:Producto controlado<p>Applications A labelled metabolite of Diphenhydramine (D486900) in humans.<br>References Breyer-Pfaff, U., et al.: Drug Metab. Dispos., 25, 340 (1997),<br></p>Fórmula:C17H15D6NO2Forma y color:NeatPeso molecular:277.39N-(4-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine
CAS:Producto controlado<p>Applications Intermediate in the preparation of Imatinib impurities. It is a COVID19-related research product.<br></p>Fórmula:C16H15N5Forma y color:NeatPeso molecular:277.324-Amino-2-fluoro-N-methylbenzamide
CAS:Producto controlado<p>Stability Moisture Sensitive<br>Applications 4-Amino-2-fluoro-N-methylbenzamide acts as a reagent in the design, synthesis and biological evaluation of novel 5-oxo-2-thioxoimidazolidine derivatives as potent androgen receptor antagonists. Also, in the preparation and structure-activity relationship of chiral benzyloxypyridinone derivatives as c-Met kinase inhibitors<br>References Ivachtchenko, A. V., et al.: Eur. J. Med. Chem., 99, 51 (2015); Zhang, D., et al.: Bioorg. Med. Chem. Lett., 23, 2408 (2013)<br></p>Fórmula:C8H9FN2OForma y color:NeatPeso molecular:168.174-(4-Amino-1-oxoisoindolin-2-yl)-4-carbamoyl Butyric Acid
CAS:Producto controladoFórmula:C13H15N3O4Forma y color:Off WhitePeso molecular:277.282-(2,4-Difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)-1,2-propanediol
CAS:Producto controlado<p>Impurity Fluconazole EP Impurity F<br>Stability Hygroscopic<br>Applications 2-(2,4-Difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)-1,2-propanediol (Fluconazole EP Impurity F) is a diol impurity of the antifungal agent Fluconazole (F421000).<br>References Dongre, V.G. et al.: J. Pharmac. Biomed. Anal., 42, 334 (2006):<br></p>Fórmula:C11H11F2N3O2Forma y color:Light YellowPeso molecular:255.224-Desfluoro-2-Fluoro Droperidol
CAS:<p>Applications 4-Desfluoro-2-Fluoro Droperidol is an impurity of Droperidol (D679500), a D1, D2 dopamine receptor antagonist; butyrophenone antipsychotic and anti-emetic.<br>References Yelnosky, J., et al.: Toxicol. Appl. Pharmacol., 6, 37 (1964), Janicki, C.A., et al.: Anal. Profiles Drug Subs., 7, 171 (1978), Hamik, et al.: Cancer Chemother. Pharmacol., 24, 307 (1989), Heyer, E.J., et al.: Brain Res., 863, 20 (2000),<br></p>Fórmula:C22H22FN3O2Forma y color:NeatPeso molecular:379.4274(R)-Propranolol-d7 Hydrochloride
CAS:Producto controlado<p>Applications The labelled R-enantiomer of Propranolol (P831800). β−Adrenergic blocker. Antihypertensive; antianginal; antiarrhythmic (class II).<br>References Bond, et al.: Nature, 213, 721 (1967), Hansteen, V., et al.: Br. Med. J., 284, 155 (1982), Diamond, S., et al.: J. Clin. Pharmacol., 28, 193 (1988),<br></p>Fórmula:C16H15D7ClNO2Forma y color:NeatPeso molecular:302.857,8-Dihydro-1-naphthalenol
CAS:<p>Stability Light Sensitive, Air (oxygen) Sensitive<br>Applications 7,8-Dihydro-1-naphthalenol can be used as reagent/reactant in stereoselective preparation of indanes via chiral hypervalent iodine - mediated ring contraction of dihydronaphthalenes<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ahmed, A., & Silva, L. F,: J. Org. Chem., 81, 2174-2181 (2016)<br></p>Fórmula:C10H10OForma y color:White To Light YellowPeso molecular:146.195-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole Hydrochloride
CAS:Producto controlado<p>Stability Hygroscopic<br>Applications An intermediate of 5-Fluoro Risperidone (F595925).<br>References Strupczewski, J.T., et al.: J. Med. Chem., 28, 761 (1985),<br></p>Fórmula:C12H13FN2O·ClHForma y color:NeatPeso molecular:256.70Hydroxymethyl Dasatinib
CAS:Producto controlado<p>Applications An oxidative metabolite of Dasatinib (M24 metabolite); used in the treatment of cancers and immune diseases. It is a COVID19-related research product.<br>References Jaworski, T., et al.: Xenobiotica, 21, 1451 (1991), Shah, N., et al.: Science, 305, 399 (2004), O'Hare, T., et al.: Cancer Res., 65, 4500 (2005), Das, J., et al.: J. Med. Chem., 49, 6819 (2006), Christopher, L., et al.: Drug Metab. Dispos., 36, 1341 (2008),<br></p>Fórmula:C22H26ClN7O3SForma y color:NeatPeso molecular:504.00rac FTY720-d4 Phosphate
CAS:Producto controlado<p>Stability Hygroscopic<br>Applications Labelled rac FTY720 (F805010). rac FTY720 is a sphingosine 1-phosphate receptor modular, ameliorates experimental autoimmune encephalomyelitis by inhibition of T cell infiltration.<br>References Igarashi, J., et al.: J. Biol. Chem., 275, 32363 (2000), Bandhuvula, P., et al.: J. Biol. Chem., 280, 33697 (2005),<br></p>Fórmula:C19H30D4NO5PForma y color:NeatPeso molecular:391.48DL-threo-Droxidopa-d3 Hydrochloride Salt Hydrate
CAS:Producto controlado<p>Applications DL-threo-Droxidopa-d3 Hydrochloride Salt Hydrate is an isotope labeled compound of DL-threo-Droxidopa (D689950), a synthetic amino acid precursor of Norepinephrine. An Antiparkinson.<br>References Bartholini, J., et al.: J. Pharmacol. Exp. Ther ., 193, 523 (1975), Kato, T., et al.: Biochem. Pharmacol., 36, 3051 (1987), Kawabata, A., et al.: Br J. Pharmacol., 111, 503 (1994)<br></p>Fórmula:C9H8D3NO5•HCl•x(H2O)Forma y color:NeatPeso molecular:216.21364618023-Amino-4-methylbenzoic Acid
CAS:Producto controlado<p>Applications 3-Amino-4-methylbenzoic acid is used as a starting material to synthesize cyclopropamitosene compounds, which have potential antitumour activity. 3-Amino-4-methylbenzoic acid also has some partial herbicidal activity.<br>References Jones, G. & Moody, C.: J. Chem. Soc., Perkin Trans., 1, 2455 (1989); Thomas, G.: J. Agr. Food Chem., 32, 747 (1984)<br></p>Fórmula:C8H9NO2Forma y color:Light BrownPeso molecular:151.16R-Amisulpride
CAS:Producto controlado<p>Stability Hygroscopic<br>Applications R-Amisulpride is an isomer of the antipsychotic Amisulpride (A633250). R-Amisulprideis a potential antidiabetic agent.<br>References Roix, J.J., et. al.: Diabetes Obesity Metab., 14, 329 (2012)<br></p>Fórmula:C17H27N3O4SForma y color:NeatPeso molecular:369.483-Methyl-8-quinolinesulfonyl Chloride
CAS:Producto controlado<p>Stability Moisture Sensitive - Store Under Inert Atmosphere<br>Applications 3-Methyl-8-quinolinesulfonyl Chloride (cas# 74863-82-4) is a compound useful in organic synthesis.<br></p>Fórmula:C10H8ClNO2SForma y color:NeatPeso molecular:241.69USP Paroxetine Related Compound E Mixture
CAS:Producto controlado<p>Applications USP Paroxetine Related Compound E Mixture is a reference standard composed of Paroxetine Hydrochloride (P205750) spiked with 4-(4-Fluorophenyl)-1,2,3,6-tetrahydro-1-methyl-pyridine Hydrochloride (F595220). Paroxetine Hydrochloride (P205750) is a selective serotonin reuptake inhibitor. Used as an antidepressant. 4-(4-Fluorophenyl)-1,2,3,6-tetrahydro-1-methyl-pyridine Hydrochloride (F595220) is the active metabolite of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) (M325910), N-Methyl-4-phenylpyridinium (MPP+), selectively destroys the dopaminergic neurons and induces the symptoms of Parkinson's disease.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lassen, J.B.: Eur. J. Pharmacol., 47, 351 (1978), Lund, J., et al.: Acta Pharmacol. Toxicol., 51, 351, (1982); Gerlach, M., et al.: Eur. J. Pharmacol., 208, 273 (1991), Tipton, K., et al.: J. Neurochem., 61, 1191 (1993), Wimalasena, D., et al.: J. Biol. Chem., 279, 15298 (2004),<br></p>Fórmula:C19H20FNO3·C12H14FN·HClForma y color:NeatPeso molecular:557.07N-Desmethyl 4-Benzyloxy Toremifene Hydrochloride
CAS:Producto controlado<p>Applications Toremifene (T547500) derivative. A triphenylalkene derivative with anti-estrogenic, and anti-tumor properties.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>Fórmula:C32H33Cl2NO2Forma y color:NeatPeso molecular:534.52N-(S)-Glycidylphthalimide
CAS:Producto controlado<p>Applications N-(S)-Glycidylphthalimide is a phthalimide derivative used as an intermediate in the preparation of the antibiotic Linezolid (L466500).<br>References Rajesh, T. et al.: Pharm. Chem., 3, 168 (2011);<br></p>Fórmula:C11H9NO3Forma y color:WhitePeso molecular:203.19Olanzapine Dimer Impurity
Producto controlado<p>Applications An impurity of Olanzapine (O253750), a serotonin (5-HT2) and dopamine (D1/D2) receptor antagonist with anticholinergic activity. Antipsychotic. Neuroprotective product.<br>References Moore, N.A., et al.: Curr. Opin Invest. Drugs, 2, 281 (1993), Baldwin, D.S. and Montgomery, S.A.: Int. Clin. Psychopharmacol., 10, 239 (1995), Tohen, M., et al.: Am. J. Psychiatry, 156, 702 (1999)<br></p>Fórmula:C29H28N6S2Forma y color:NeatPeso molecular:524.7035-Chloro-N-methylthiophene-2-carboxamide
CAS:Producto controlado<p>Applications 5-Chloro-N-methylthiophene-2-carboxamide is an impurity of Rivaroxaban (R538000), which is a novel antithrombotic agent. A highly potent and selective, direct FXa inhibitor.<br>References Ansell, J., et al.: Drugs, 64, 1 (2004), Eriksson, B., et al.: J. Thromb. Haemost., 3, 103 (2005), Kubitza, D., et al.: Clin. Pharmacol. Ther., 78, 412 (2005),<br></p>Fórmula:C6H6ClNOSForma y color:NeatPeso molecular:175.642-[[(3aR,4S,6R,6aS)-6-[[5-Amino-6-chloro-2-(propylthio)-4-pyrimidinyl]amino]tetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol
CAS:Producto controlado<p>Applications 2-[[(3aR,4S,6R,6aS)-6-[[5-Amino-6-chloro-2-(propylthio)-4-pyrimidinyl]amino]tetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol is used as a reagent in the synthesis of Ticagrelor (T437700) derivatives as antiplatelet agents.<br>References Zhang, H., et al.: Bioorg. Med. Chem. Lett., 22, 3598 (2012)<br></p>Fórmula:C17H27ClN4O4SForma y color:NeatPeso molecular:418.94(Z)-4-(2,4-Difluorobenzoyl)piperidine Oxime
CAS:Producto controlado<p>Applications Intermediate in the preparation of Risperidone (R525000) and it’s derivatives.<br></p>Fórmula:C12H14F2N2OForma y color:NeatPeso molecular:240.2492N-Methyl Omeprazole-d3 (Mixture of isomers with the methylated nitrogens of imidazole)
CAS:Producto controlado<p>Applications Labelled Omeprazole (O635000) impurity.<br>References Allenmark, S., et al.: Anal. Biochem., 136, 293 (1984), Besancon, M., et al.: J. Biol. Chem., 272, 22438 (1997),<br></p>Fórmula:C18H18D3N3O3SForma y color:NeatPeso molecular:362.461-(4-(4-(tert-Butyl)phenyl)-4-hydroxybutyl)-4-piperidinecarboxylic Acid Ethyl Ester
CAS:Producto controladoFórmula:C22H35NO3Forma y color:NeatPeso molecular:361.52ZK 159222
CAS:Producto controlado<p>Stability Light Sensitive, Temperature Sensitive<br>Applications ZK 159222 is a vitamin D receptor antagonist. It is a derivative of Vitamin D3 (V676045).<br>References Mizwicki, M., et al.: J. Bio. Chem., 284, 36292 (2009); Ochiai, E., et al.: Mol. Endocrinol., 19, 1147 (2005)<br></p>Fórmula:C32H48O5Forma y color:NeatPeso molecular:512.72rac Desmethyl Citalopram-d4 Hydrobromide
CAS:Producto controlado<p>Applications rac Desmethyl Citalopram-d4 Hydrobromide is the labeled analogue of rac Desmethyl Citalopram Hydrobromide (D230870), a metabolite of Citalopram (C505000), an inhibitor of serotonin (5-HT) uptake. Used as an antidepressant.<br>References Gnerre, C., et al.: J. Pharm. Pharmacol., 53, 1125 (2001); Hagg, S., et al.: Br. J. Clin. Pharmacol., 51, 169 ( 2001); von Moltke, L., et al.: Drug Metab. Dispos., 29, 1102 (2001); Reis, M., et al.: Ther. Drug Monit., 27, 469 (2005)<br></p>Fórmula:C19H16D4BrFN2OForma y color:NeatPeso molecular:395.3Telmisartan Amide
CAS:<p>Impurity Telmisartan EP Impurity F / Telmisartan Amide<br>Applications An amide impurity of Temisartan (D294250).<br>References Xu, G. et al.: Zhong. Yiyao Gong. Zaz., 40, 714 (2009);<br></p>Fórmula:C33H31N5OForma y color:NeatPeso molecular:513.632,3,3a,12b-Tetradehydro Asenapine
CAS:Producto controladoFórmula:C17H12ClNOForma y color:NeatPeso molecular:281.74
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