Derivados de Quinazolina y Quinolina
Las quinazolinas y quinolinas son compuestos heterocíclicos nitrogenados con estructuras aromáticas que desempeñan un papel clave en la síntesis de fármacos con actividad anticancerígena, antimicrobiana y antiinflamatoria. Sus derivados presentan modificaciones estructurales que optimizan su biodisponibilidad y selectividad, lo que permite el desarrollo de nuevos principios activos para diversas aplicaciones terapéuticas. Estos compuestos se utilizan en la fabricación de APIs destinados al tratamiento de cáncer, infecciones, enfermedades neurodegenerativas y cardiovasculares. Además, los derivados de quinazolina y quinolina son esenciales en la investigación de inhibidores enzimáticos y en el diseño de moléculas bioactivas innovadoras. En CymitQuimica disponemos de derivados de quinazolina y quinolina de alta pureza para aplicaciones en síntesis química, desarrollo farmacéutico y biotecnología.
Se han encontrado 65630 productos de "Derivados de Quinazolina y Quinolina"
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Rivaroxaban-d4
CAS:Producto controladoFórmula:C19H14D4ClN3O5SForma y color:White To Off-WhitePeso molecular:439.914-Desmethoxypropoxyl-4-chloro Rabeprazole
CAS:Producto controlado<p>Impurity Rabeprazole EP Impurity H (Lansoprazole EP Impurity F)<br>Applications 4-Desmethoxypropoxyl-4-chloro Rabeprazole (Rabeprazole EP Impurity H (Lansoprazole EP Impurity F)) is a process impurity of Rabeprazole (R070500).<br></p>Fórmula:C14H12ClN3OSForma y color:NeatPeso molecular:305.78(2R,4R)-2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolane-4-methanol 4-(4-Methylbenzenesulfonate)
CAS:Producto controladoFórmula:C21H20Cl2N2O5SForma y color:NeatPeso molecular:483.3652,6-Dimethylaniline-d6
CAS:Producto controlado<p>Applications Labelled Bupivacaine (B689560) impurity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lepage, F., et al.: Eur. J. Med. Chem., 27, 581 (1992), Thummel, K.E., et al.: Drug Metab. Dispos., 21, 350 (1993)<br></p>Fórmula:C82H6H5NForma y color:BrownPeso molecular:127.22rac N-Propyl-2-cyanimidopyrrolidine-5-acetic Acid
CAS:Producto controlado<p>Applications rac N-Propyl-2-cyanimidopyrrolidine-5-acetic Acid is a potent peptidic renin inhibitor. Pramipexole Related Compound<br></p>Fórmula:C10H15N3O2Forma y color:NeatPeso molecular:209.24Lansoprazole-d4
CAS:Producto controladoFórmula:C162H4H10F3N3O2SForma y color:NeatPeso molecular:373.39Dipyridamole Tri(diethanolamine)
CAS:Producto controlado<p>Impurity Dipyridamole EP Impurity B<br>Applications Dipyridamole Tri(diethanolamine) (Dipyridamole EP Impurity B) Dipyridamole (D492625) impurity.<br>References Gerlach, E., et al.: Arzneim.-Forsch., 15, 558 (1965),<br></p>Fórmula:C23H40N8O6Forma y color:NeatPeso molecular:524.61Sulindac Sulfide
CAS:<p>Stability Hygroscopic<br>Applications An active metabolite of Sulindac. Inhibits cyclooxygenase, but induces apoptosis by a cyclooxygenase-independent mechanism. Inhibition of Ras activation of Ref-1. Impairs nucleotide exchange on Ras by CDC25 and accelerates Ras hydrolysis of GTP by p120GAP.<br>References Hermann, C., et al.: Oncogene, 17, 1769 (1998), Lim, T.J., et al.: Biochem. Pharmacol., 58, 1097 (1999), Zhang, Z. and DuBois, R.N.: Gastroenterology, 118, 1012 (2000),<br></p>Fórmula:C20H17FO2SForma y color:Yellow-OrangePeso molecular:340.41(Z)-Flunarizine
CAS:Producto controlado<p>Impurity Flunarizine EP Impurity D<br>Applications (Z)-Flunarizine is Z-isomer of Flunarizine(F455200, Dihydrochloride), which is a calcium channel blocker. Flunarizine is a fluorinated derivative of Cinnarizine and a vasodilator (cerebral and peripheral). EP Impurity C<br>References Desmedt, L.K., et al.: Arzneim.-Forsch., 25, 1408 (1975), Godfraind, T., et al.: Eur. J. Pharmacol., 53, 273 (1979), Nihard, P., et al.: Angiology, 33, 37 (1982), Holmes, B., et al.: Drugs, 27, 6 (1984),<br></p>Fórmula:C26H26F2N2Forma y color:NeatPeso molecular:404.49(1RS)-1-(6-Methoxy-2-naphthyl)ethanol (Naproxen Impurity K)
CAS:Producto controlado<p>Impurity Naproxen EP Impurity K<br>Applications Naproxen impurity K.<br>References Boynton, C., et al.: J. Clin. Pharmacol., 28, 512 (1988), Li, J., et al.: J. Med. Chem., 39, 1846 (1996), Monser, L., et al.: J. Pharm. Biomed. Anal., 27, 851 (2002),<br></p>Fórmula:C13H14O2Forma y color:White To Light YellowPeso molecular:202.25N-Desmethyl Riociguat
CAS:Producto controlado<p>Applications N-Desmethyl-riociguat, is a complex that is part affiliated with potent oral stimulator for the treatment of pulmonary hypertension.<br>References Mittendorf, J., et al.: ChemMedChem., 4, 853 (2009)<br></p>Fórmula:C19H17FN8O2Forma y color:NeatPeso molecular:408.393-(5-Nitrofurfurylideneamino)hydantoic Acid
CAS:<p>Impurity Nitrofurantoin USP Related Compound A<br>Applications 3-(5-Nitrofurfurylideneamino)hydantoic Acid, is a new derivative of 5-Nitro-2-furfural, and they are proved to be bactericidal. Nitrofurantoin USP Related Compound A.<br>References Swirska, A., et al.: Rocz. Chem., 31, 1335 (1957);<br></p>Fórmula:C8H8N4O6Forma y color:YellowPeso molecular:256.177-(Diethylamino)-3-(thiophen-2-yl)-2H-chromen-2-one
CAS:Pureza:98% HPLC,TPeso molecular:299.3900146484375N-Formyl Amlodipine
CAS:Producto controlado<p>Applications N-Fomyl Amlodipine acts as a reagent for the synthesis of dihydropyridine anti-ischemic and antihypertensive agents.<br>References Alker, D., et al.: Pat. Appl. (1984), EP 119050 A2 19840919<br></p>Fórmula:C21H25ClN2O6Forma y color:White To Off-WhitePeso molecular:436.886Astemizole
CAS:Producto controlado<p>Applications Nonsedating-type histamine H1-receptor antagonist. Potential for combination therapy with antivancer drugs such as doxorubicin in resistant leukemia. Antihistaminic.<br>References Wauquier, A., et al.: Eur. J. Pharmacol., 72, 245 (1981), Laduron, P.M., et al.: Mol. Pharmacol., 21, 294 (1982), Richards, D.M., et al.: Drugs, 28, 38 (1984), Al-Obaid, A.M., et al.: Anal. Profiles Drug Subs., 20, 173 (1991), Ishikawa, M., et al.: Biol. Pharm. Bull., 23, 112 (2000),<br></p>Fórmula:C28H31FN4OForma y color:White To Off-WhitePeso molecular:458.57rac Viloxazine-d5 Hydrochloride
CAS:Producto controlado<p>Applications Labelled Viloxazine (V312440). Antidepressant.<br>References Howe, R., et al.: J. Med. Chem., 19, 1074 (1976), Pinder, R.M., et al.: Drugs, 13, 401 (1977),<br></p>Fórmula:C13H15D5ClNO3Forma y color:NeatPeso molecular:278.79Olanzapine LIP 1 Acetyl
CAS:<p>Applications Olanazpine LIP 1 Acetyl is an Olanazpine impurity. Olanazpine is an antipsychotic medicine.<br>References Perera, V., et al.: Br. J. Clin. Pharmacol., 78, 800 (2014); Pratt, N., et al.: Pharmacoepidemiol. Drug Saf., 22, 915 (2013)<br></p>Fórmula:C18H20N4OSForma y color:YellowPeso molecular:340.44Hemiacetorphan
CAS:Producto controlado<p>Applications Hemiacetorphan is an impurity of Racecadotril (R070600), which is antidiarrheal, enkephalinase inhibitor, and also capable of reducing the amount of water and electrolytes into the intestine.<br>References Cezard, J., et al.: Gastroenterol., 120, 799 (2001), Sato, T., et al.: J. Med. Chem., 51, 7705 (2008), Lakshmana, P., et al.: J. Pharm. Res., 8, 39 (2009),<br></p>Fórmula:C14H17NO4SForma y color:NeatPeso molecular:295.35Tulobuterol-d9 Hydrochloride
CAS:Producto controlado<p>Applications Labelled Tulobuterol (T897250). A sympathomimetic drug used as a transdermal patch, increases normal diaphragm muscle strength. A β-adrenergic receptor agonist, related structurally to Terbutaline (T109750).<br>References Kubo, S., et al.: Arzneim.-Forsch., 25, 1028 (1975), Uematsu, T., et al.: Eur. J. Clin. Pharmacol., 44, 361 (1993), Qureshi, S., et al.: J. Exp. Med., 189, 615 (1999),<br></p>Fórmula:C122H9H9ClNO·ClHForma y color:White To Off WhitePeso molecular:273.25Deschloro Aripiprazole
CAS:Producto controlado<p>Impurity Aripiprazole EP Impurity C<br>Applications Deschloroaripiprazole (Aripiprazole EP Impurity C) is a derivative of Aripiprazole (A771000), a dopamine D2 receptor agonist. Antipsychotic.<br>References Chen, X. et al.: J. Med. Chem., 55, 7141 (2012); Canive, J.M., et al.: Psychopharmacol. Bull., 34, 101 (1998), Oshiro, Y., et al.: J. Med. Chem., 41, 658 (1998),<br></p>Fórmula:C23H28ClN3O2Forma y color:Off-WhitePeso molecular:413.94Sertindole
CAS:Producto controlado<p>Applications Antipsychotic used in the treatment of schizophrenia.<br>References Nourian, Z., et al.: Eur. J. Pharmacol., 596, 32 (2008), Karczewski, J., et al.: Biochem. Pharmacol., 77, 1602 (2009), Isoherranen, N., et al.: Chem. Res. Toxicol., 22, 294 (2009), Goetghebeur, P., et al.: Psychopharmacol., 202, 287 (2009),<br></p>Fórmula:C24H26ClFN4OForma y color:NeatPeso molecular:440.943-Hydroxy-4-morpholino-1,2,5-thiazole
CAS:<p>Impurity Timolol EP Impurity D; Timolol BP Impurity D; Timolol USP Related Compound D<br>Applications 3-Hydroxy-4-morpholino-1,2,5-thiazole (Timolol EP Impurity D; Timolol BP Impurity D; Timolol USP Related Compound D) is an intermediate for the preparation of Timolol.<br>References Bodor, N., et al.: J. Med. Chem., 31, 100 (1988),<br></p>Fórmula:C6H9N3O2SForma y color:White To Off-WhitePeso molecular:187.22Carprofen Glucuronide
CAS:<p>Stability Hygroscopic<br>Applications Carprofen Glucuronide is a derivative of Carprofen (C184350), a non steroidal anti-inflammatory that is used by veterinarians for the relief of arthritic systems in dogs. It can be used for joint pain or post operative inflammation. Carprofen, is also used for the relief from pain and inflammation associated with osteoarthritis, hip dysplasia and other joint issues.<br>References Randall, L.O., et al.: Arch. Int. Pharmacodyn., 220, 94 (1976), Yu, T.F., et al.: J. Clin. Pharmacol., 20, 347 (1980), O’Brien, W.M., et al.: Pharmacotherapy, 7, 16 (1987),<br></p>Fórmula:C21H20ClNO8Forma y color:Light BrownPeso molecular:449.843-Cyclohexyl-6,8-dibromo-3-methyl-1,2,3,4-tetrahydroquinazolinium Chloride
CAS:<p>Impurity Bromhexine EP Impurity E Chloride<br>Applications 3-Cyclohexyl-6,8-dibromo-3-methyl-1,2,3,4-tetrahydroquinazolinium Chloride is an impurity of Bromhexine Hydrochloride (B678600). Bromhexine Hydrochloride impurity E Chloride. Bromhexine is an expectorant; mucolytic.<br>References Goicoechea, H., et al.: Talanta, 49, 793 (1999), Ribone, M., et al.: J. Pharm. Biomed. Anal., 23, 591 (2000),<br></p>Fórmula:C15H21Br2N2·ClForma y color:NeatPeso molecular:424.61Tianeptine
CAS:<p>Applications Tricyclic compound with psychostimulant, anti-ulcer and anti-emetic properties. Antidepressant.<br>References Malen, C., et al.: Experientia, 28, 811 (1972), Safa, A., et al.: J. Biol. Chem., 262, 7884 (1987), Ford, J.M., et al.: Pharmacol. Rev., 42, 155, (1990), Pierre, A., et a.: Cancer Res., 51, 2312 (1991),<br></p>Fórmula:C21H25ClN2O4SForma y color:White To Off-WhitePeso molecular:436.95Bufuralol Hydrochloride
CAS:Producto controlado<p>Applications A β-Adrenergic blocker with peripheral vasodilating activity. Antianginal; antihypertensive.<br>References Francis, R.J., et al.: Eur. J. Clin. Pharmacol., 23, 529 (1982), Pfisterer, M., et al.: J. Cardiovasc. Pharmacol., 6, 417 (1984), Narimatsu, S., et al.: J. Pharmacol. Exp. Ther., 303, 172<br></p>Fórmula:C16H23NO2·ClHForma y color:White To Light BeigePeso molecular:297.82Deoxy Epinephrine Hydrochloride
CAS:Producto controlado<p>Stability Hygroscopic<br>Applications Andregenic and dopamine receptor agonist; active metabolite of Ibopramine (I123500). Also, it is used as internal standard in chromatographic analysis of catecholamines.<br>References Kindler, P., et al.: Arch. Pharm., 270, 340 (1932), Bridgers, W.F., et al.: J. Biol. Chem., 237, 526 (1962),<br></p>Fórmula:C9H13NO2·ClHForma y color:Light Brown To PurplePeso molecular:203.67N-Boc Linagliptin
CAS:Producto controlado<p>Applications N-Boc Linagliptin is an impurity of linagliptin (L465900), which is a novel potent and selective dipeptidyl peptidase-4 (DPP-4) inhibitor with potential use in the treatment of type 2 diabetes.<br>References Prabavathy, N. et al.: Int. J. Pharm. Bio. Sci., 2, 438 (2011); Deacon, C.F.: Diab. Obes. Metab., 13, 7 (2011);<br></p>Fórmula:C30H36N8O4Forma y color:NeatPeso molecular:572.66Tadalafil-d3
CAS:Producto controlado<p>Stability Unstable in Methanol<br>Applications Tadalafil is used for the treatment of erectile dysfunction. A phosphodiesterase 5 inhibitor.<br>References Carrier, S., et al.: Can. J. Urol., 10(1), 12 (2003), Doggrell, S.A., et al.: Expert Opin. Pharmacother., 6, 75 (2005), Forgue, S.T., et al.: Br. J. Clin. Pharmacol., 61, 280 (2005),<br></p>Fórmula:C222H3H16N3O4Forma y color:White SolidPeso molecular:392.42Hydrolyzed Pomalidomide M11
CAS:Producto controladoFórmula:C13H13N3O5Forma y color:NeatPeso molecular:291.26Empagliflozin (Tetrahydrofuranyl-d4)
CAS:Producto controlado<p>Applications Empagliflozin-d4 is a labelled analog of Empagliflozin (E521510); a novel, potent and selective SGLT-2 inhibitor, improves glycaemic control and features of metabolic syndrome in diabetic rats.<br>References Thomas, L., et al.: Diabetes. Obesity. Metabol. 14, 94 (2012); Grempler, R., et al.: Diabetes. Obesity. Metabol., 14, 83 (2012);<br></p>Fórmula:C23D4H23ClO7Forma y color:NeatPeso molecular:454.934Empagliflozin α-Anomer
CAS:Producto controladoFórmula:C23H27ClO7Forma y color:White To Off-WhitePeso molecular:450.9096'-Methoxy-2'-acetonaphthone (Naproxen Impurity L)
CAS:Producto controlado<p>Impurity Naproxen USP Related Compound L<br>Applications Naproxen impurity L. Naproxen USP Related Compound L<br>References Boynton, C., et al.: J. Clin. Pharmacol., 28, 512 (1988), Li, J., et al.: J. Med. Chem., 39, 1846 (1996), Monser, L., et al.: J. Pharm. Biomed. Anal., 27, 851 (2002),<br></p>Fórmula:C13H12O2Forma y color:BeigePeso molecular:200.233Gabapentin Related Compound E
CAS:Producto controlado<p>Impurity Gabapentin USP Related Compound E<br>Applications A Gabapentin (G117250) analogue. Gabapentin USP Related Compound E.<br>References Edafiogho, I., et al.: J. Med. Chem., 34, 387 (1991), Alexander, M., et al.: Eur. J. Med. Chem., 31, 787(1996), Obniska, J., et al.: Pharmacol. Rep., 57, 170 (2005)<br></p>Fórmula:C9H14O4Forma y color:NeatPeso molecular:186.217-(4-Bromobutoxy)-3,4-dihydroquinolin-2-one
CAS:Producto controlado<p>Impurity Aripiprazole Bromobutoxyquinoline Impurity<br>Stability Hygroscopic<br>Applications An impurity in the synthesis of Aripiprazole (A771000). A degradation product in Aripiprazole tablets. Aripiprazole Bromobutoxyquinoline Impurity<br>References Reddy, G.V.R., et al.: Eur. J. Chem., 1, 20 (2010),<br></p>Fórmula:C13H16BrNO2Forma y color:White To Off-WhitePeso molecular:298.18(E)-2-Chloro-3-imino-N,N-dimethylprop-1-en-1-amine Hydrochloride
CAS:Producto controlado<p>Applications (E)-2-chloro-3-imino-N,N-dimethylprop-1-en-1-amine Hydrochloride is an impurity of Etoricoxib (E934100), a selective cyclo-oxygenase-2 (COX-2) inhibitor that is used to improve the signs and symptoms of osteoarthritis and rheumatoid arthritis.<br>References Hunt, R., et al.: Am. J. Gastroenterol., 98, 1725 (2003); Schumacher Jr., H., et al.: Bmj, 324, 1488 (2002)<br></p>Fórmula:C5H9ClN2·HClForma y color:Light YellowPeso molecular:169.052-[-2[(5-Nitro-2-furanyl)methylene]hydrazinyl]acetic Acid
CAS:Producto controlado<p>Applications 2-[-2[(5-Nitro-2-furanyl)methylene]hydrazinyl]acetic Acid is an impurity of Nitrofurantoin (N493850), a nitrofuran antibiotic with low resistance potential that is rapidly metabolized by mammals.<br>References Cadwallader, D.E., et al.: Anal. Profiles Drug Subs., 5, 345 (1976); Rogers, R.G., et al.: Am. J. Obstr. Gynecol., 191, 182 (2004);<br></p>Fórmula:C7H7N3O5Forma y color:NeatPeso molecular:213.1483-Hydroxyagomelatine
CAS:<p>Impurity Agomelatine Impurity 11/ Agomelatine 3-Hydroxy Impurity<br>Applications 3-Hydroxyagomelatine is an intermediate in the synthesis of 1-(aminoethyl)naphthalene derivative with potential binding affinity for melatonin receptors. Agomelatine Impurity 11<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Simonin, G., et al.: J. Pharma. Biomed. Anal., 21, 591 (1999)<br></p>Fórmula:C15H17NO3Forma y color:NeatPeso molecular:259.3Mavoglurant
CAS:Producto controlado<p>Applications Mavoglurant is a non-competitive metabotropic glutamate receptor 5 (mGlu5) receptor antagonist.<br>References Vranesic, I., et al.; Bioorg. Med. Chem., 22, 5790 (2014); Kubas, H., et al.: Bioorg. Med. Chem. Lett., 23, 6370 (2013)<br></p>Fórmula:C19H23NO3Forma y color:NeatPeso molecular:313.39Ebastine
CAS:<p>Applications A nonsedating type histamine H1-receptor antagonist. Antihistaminic.<br>References Fliri, A., et al.: J. Med. Chem., 52, 8038 (2009), Inomata, N., et al.: J. Dermatol., 36, 224 (2009), Carvajal, A., et al.: Clin. Pharmacol. Ther., 85, 481 (2009), Yamashita, S., et al.: Mol. Pharm., 6, 48 (2009),<br></p>Fórmula:C32H39NO2Forma y color:White To Off-WhitePeso molecular:469.66
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