Nucleósidos y Nucleótidos
Los nucleósidos son compuestos formados por una base nitrogenada unida a una azúcar (ribosa o desoxirribosa). Cuando un grupo fosfato se añade al nucleósido, se forma un nucleótido. Estos compuestos son fundamentales en la biología celular, ya que los nucleótidos son los bloques básicos del ADN y ARN, responsables de almacenar y transmitir información genética. Los nucleósidos tienen aplicaciones en el tratamiento de enfermedades virales, como inhibidores de la replicación viral. Los nucleótidos, además de su rol estructural en los ácidos nucleicos, intervienen en procesos energéticos, como en la síntesis de ATP.
En CymitQuimica contamos con una amplia gama de nucleósidos y nucleótidos esenciales para investigación en biología molecular, virología y farmacología.
Se han encontrado 3421 productos de "Nucleósidos y Nucleótidos"
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α-Decitabine
CAS:Producto controlado<p>Applications α-Decitabine is shown to inhibit DNA methylation resulting in an effective anticancer agent.<br>References Hajek, M. et al.: Biochem. Pharm., 75, 965 (2008); Rogstad, D. et al.: Chem. Res. Toxicol., 22, 1194 (2009);<br></p>Fórmula:C8H12N4O4Forma y color:NeatPeso molecular:228.212,4-Diamino-6-hydroxypyrimidine
CAS:Producto controlado<p>Applications 2,4-Diamino-6-hydroxypyrimidine (cas# 56-06-4) is a compound useful in organic synthesis.<br></p>Fórmula:C4H6N4OForma y color:NeatPeso molecular:126.12Abacavir-d4
CAS:Producto controlado<p>Stability Very Hygroscopic<br>Applications Abacavir-d4 is deuterium labeled Abacavir (A104990). Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.<br>References (1) Jackson, A., et al.: Antivir Ther. 17, 19 (2012) (2) Yuen, G. J., et al.: Clin Pharmacokinet. 47, 351 (2008)<br></p>Fórmula:C14H14D4N6OForma y color:Off-WhitePeso molecular:290.361’-epi-Cladribine
CAS:<p>Applications 1’-epi-Cladribine is an impurity of Cladribine (C557500), a substituted purine nucleoside with antileukemic activity.<br>References Seto, S., et al.: J. Clin. Invest., 75, 377 (1985), Piro, L.D., et al.: N. Engl. J. Med., 322, 1117 (1990),<br></p>Fórmula:C10H12ClN5O3Forma y color:NeatPeso molecular:285.69Barbituric Acid
CAS:<p>Impurity Fluorouracil EP Impurity A<br>Applications Barbituric Acid (Fluorouracil EP Impurity A) is a parent compound of barbiturate drugs. Unsubstituted barbituric acid has no hypnotic properties.<br>References Luo, Y., et al.: J. Med. Chem., 53, 3846 (2010), Tomasic, T., et al.: Eur. J. Med. Chem., 45, 1667 (2010), Gilbert, A., et al.: Bioorg. Med. Chem. Lett., 20, 636 (2010),<br></p>Fórmula:C4H4N2O3Forma y color:NeatPeso molecular:128.09Floxuridine-13C,15N2
CAS:Producto controlado<p>Applications Labelled Floxuridine. Antiviral; antineoplastic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Harris, M., et al.: Biophys. J., 4, 203 (1964),<br></p>Fórmula:C813CH11F15N2O5Forma y color:WhitePeso molecular:249.17Melamine-15N3
CAS:<p>Applications Isotope labelled Melamine (M208703), which forms synthetic resins with formaldehyde. It remains largely non-metabolized in male Wistar rats with 90% of the administered dose excreted in the urine (1,2) and thus acts as a non-protein nitrogen food additive found in milk (3). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.<br>References 1. Mast, R. et al.: Food Chem Toxicol. 1983 Dec;21(6):807-10.2. Smith, J. et al.: Toxicol Appl Pharmacol. 1994 Apr;125(2):296-308.3. Anirudhan, T. et al.: Food Chem. 2017 Jul 15;227:85-92.<br></p>Fórmula:C3H615N3N3Forma y color:White To Off-WhitePeso molecular:129.10Laninamivir
CAS:<p>Applications A new potent neuraminidase (NA) inhibitor, shows long-acting anti-influenza virus activity.<br>References Bantia, S., et al.: Antimicrob. Agents Chemother., 42, 801 (1998), Honda, T., et al.: Bioorg. Med. Chem. Lett., 12, 1925 (2002), Kiso, M., et al.: Lancet, 364, 759 (2004), Macdonald, S., et al.: J. Med. Chem., 48, 2964 (2005),<br></p>Fórmula:C13H22N4O7Forma y color:White To Off-WhitePeso molecular:346.34Dapagliflozin hydroxy Impurity (Mixture of Diastereomers)
CAS:<p>Applications (1S)-1,5-anhydro-1-C-[4-Chloro-3-[(4-ethoxyphenyl)hydroxymethyl]phenyl]-D-glucitol is an impurity of the drug Dapagliflozin (D185370), a sodium-glucose transporter 2 inhibitor.<br>References Kasichayanula, S. et al.: Diabetes, Obesity and Metabolism 13, 47 (2011)<br></p>Fórmula:C21H25ClO7Forma y color:White To Off-WhitePeso molecular:424.8721,3-Dioxolane (Stabilized with BHT)
CAS:Producto controladoFórmula:C3H6O2Forma y color:NeatPeso molecular:74.08Zanamivir
CAS:Producto controlado<p>Applications Influenza viral neuraminidase inhibitor; structural analog of the sialic acid. Antiviral.<br>References Woods, J.M., et al.: Antimicrob. Agents Chemother., 37, 1473 (1993), Pegg, M.S., et al.: Biochem. Mol. Biol. Int., 32, 851 (1994), Monto, A.S., et al.: J. Am. Med. Assoc., 282, 31 (1999),<br></p>Fórmula:C12H20N4O7Forma y color:NeatPeso molecular:332.31Entecavir
CAS:<p>Applications An oral antiviral drug used in the treatment of hepatitis B infection. A guanine analogue that inhhibits all three steps in the viral replication process.<br>References Innaimo, S.F., et al.: Antimicrob. Agents Chemother., 41, 1444 (1997), Honkoop, P., et al.: Expert Opin. Invest. Drugs, 12, 683 (2003), Chang, T.-T., et al.: N. Engl. J. Med., 354, 1001 (2006),<br></p>Fórmula:C12H15N5O3Forma y color:NeatPeso molecular:277.28Adenosine-3’,5’-cyclic Monophosphate
CAS:<p>Stability Hygroscopic<br>Applications Adenosine-3’,5’-cyclic Monophosphate is an Adenosine (A280400) derivative useful as anticancer agent.<br>References Keast, R., et al.: Pharma. Res., 19, 1019 (2002),<br></p>Fórmula:C10H12N5O6PForma y color:NeatPeso molecular:329.21[1',2',3',4',5'-13C5]Uridine
CAS:Producto controlado<p>Applications Labelled Uridine, a nucleoside; widely distributed in nature. Uridine is one of the four basic components of ribonucleic acid (RNA)<br>References Lorine, P., et al.: J. Biol. Chem., 178, 439 (1949); Grakoui, A., et al.: J. Virol., 63, 5216 (1989); Strauss, J., et al.: Microbiol. Rev., 58, 491 (1994); Lin, Y., et al.: Virology, 292, 78 (2002);<br></p>Fórmula:C5C4H12N2O6Forma y color:NeatPeso molecular:249.16Etravirine
CAS:Producto controlado<p>Applications Etravirine is a novel HIV reverse transcriptase inhibitor useful in treatment of HIV infection.<br>References Scholler-Gyure, M., et al.: J. Clin. Pharmacol., 48, 322 (2008), Thakur, A., et al.: Eur. J. Med. Chem., 43, 471 (2008),<br></p>Fórmula:C20H15BrN6OForma y color:White To Off-WhitePeso molecular:435.285-Aza Cytosine
CAS:Producto controlado<p>Impurity Azacitidine USP Related Compound A<br>Applications Inhibits the growth of Escherichia coli. Azacitidine USP Related Compound A.<br>References Shapir, N., et al.: J. Bacteriol., 184, 5376 (2002), Hrdlicka, P., et al.: Bioorg. Med. Chem., 13, 1249 (2005), Krecmerova, M., et al.: J. Med. Chem., 50, 1069 (2007),<br></p>Fórmula:C3H4N4OForma y color:White SolidPeso molecular:112.09Baquiloprim
CAS:<p>Stability Hygroscopic<br>Applications Baquiloprim is an amiopyrimidine antibacterial synergist with high activity and slow elimination. Baquiloprim has a better half-life than trimethoprim.<br>References Zhi-hui, H., et al.: Anhui Nongye Kexue, 41, 2503 (2013)<br></p>Fórmula:C17H20N6Forma y color:Light YellowPeso molecular:308.382’-Deoxycytidine 5'-Monophosphate Hydrate
CAS:Producto controlado<p>Applications A phosphorylated metabolite of the deoxyribonucleoside 2’-Deoxycytidine. A constituent of Deoxyribonucleic acid. Studies show that it increases influenza virus antigen-induced immune cell proliferation.<br>References Holen, E. et al.: Nutrition, 21, 1003 (2005); Alexandre, J.A. et al.: Nucleosides Nucleotides Nucelic Acids, 26, 1375 (2007);<br></p>Fórmula:C9H14N3O7P·xH2OForma y color:White To Off-WhitePeso molecular:307.20 + x(18.02)Ribavirin-13C2
CAS:Producto controlado<p>Applications Ribavirin-13C2 is the labeled analogue of Ribavirin (R414475), a purine nucleoside analog; inhibits inosine monophosphate dehydrogenase (IMPDH). Used as an antiviral agent.This compound is suitable for pyruvate dehydrogenase (PDH) related research.<br>References Fernandez, H., et al.: Eur. J. Epidemiol., 2, 1 (1986); Liao, H.J. and Stollar, V.: Antiviral Res., 22, 285 (1993); Honda, Y., et al.: Antimicrob. Agents Chemother., 38, 653 (1994); Reichard, O., et al.: Lancet, 351, 83 (1998)<br></p>Fórmula:C613C2H12N4O5Forma y color:WhitePeso molecular:246.19Gemcitabine-13C,15N2 Hydrochloride
CAS:<p>Stability Hygroscopic<br>Applications Labelled Gemcitabine, an antineoplastic.<br>References Hertel, L.W., et al.: Cancer Res., 50, 4417 (1990), Abbruzzese, J.L., et al.: J. Clin. Oncol., 9, 491 (1991), Ruiz, V.W.T., et al.: Biochem. Pharmacol., 46, 762 (1993),<br></p>Fórmula:C813CH12ClF2N15N2O4Forma y color:Off-WhitePeso molecular:302.64D-Glucono-1,5-lactone
CAS:Producto controlado<p>Applications A lactone (cyclic ester) of D-gluconic acid used as a used as a sequestrant, an acidifier, or a curing, pickling, or leavening agent.<br>References Jacob, M. et al.: Food Hydrocoll., 25, 928 (2011); Li, J. et al.: J. Sci. Food Agric., 91, 38, 2011;<br></p>Fórmula:C6H10O6Forma y color:NeatPeso molecular:178.142’,2’-Difluoro-2’-deoxyuridine
CAS:Producto controladoFórmula:C9H10F2N2O5Forma y color:White To Off-WhitePeso molecular:264.18Dapagliflozin Tetraacetate
CAS:<p>Applications Dapagliflozin Tetraacetate is a derivative of Dapagliflozin [D226255], a sodium-glucose transporter 2 inhibitor.<br>References Kasichayanula, S. et al.: Diabetes, Obesity and Metabolism 13, 47 (2011); Bernhardson, D. et al.: Org. Proc. Res. Dev., 18, 57 (2014);<br></p>Fórmula:C29H33ClO10Forma y color:WhitePeso molecular:577.025-Fluoro Cytosine
CAS:Producto controlado<p>Applications 5-FC is a toxic antifungal/antimicrobial agent.<br>References Gopinath, P., et al.: Biotechnol. Lett., 30, 1913 (2008), Kalkanci, A., et al.: Microbiol Immunol., 52, 435 (2008), Dubeau, M., et al.: App. Env. Microbiol., 75, 1211 (2009),<br></p>Fórmula:C4H4FN3OForma y color:White To Off-WhitePeso molecular:129.09α-Decitabine-3',5'-bis(4-chlorobenzoate)
CAS:Producto controladoFórmula:C22H18Cl2N4O6Forma y color:White To Off-WhitePeso molecular:505.308Adenosine-13C5
CAS:<p>Stability Hygroscopic<br>Applications Labelled nucleotide.<br>References Long, X., et al.: J. Pharmacol. Exper. Ther., 335, 781 (2010), Ham, M., et al.: J. Pharmacol. Exper. Ther., 335, 607 (2010),<br></p>Fórmula:C513C5H13N5O4Forma y color:White To Off-WhitePeso molecular:272.20N-Des-1-β-D-ribofuranosyl Ribavirin
CAS:<p>Impurity Ribavirin EP Impurity D<br>Applications N-Des-1-β-D-ribofuranosyl Ribavirin (Ribavirin EP Impurity D) is an impurity in the synthesis of Ribavirin (R414475), a purine nucleoside analog; inhibits inosine monophosphate dehydrogenase (IMPDH). Used as an antiviral agent.This compound is suitable for pyruvate dehydrogenase (PDH) related research.<br>References Fernandez, H., et al.: Eur. J. Epidemiol., 2, 1 (1986), Liao, H.J. and Stollar, V.: Antiviral Res., 22, 285 (1993), Honda, Y., et al.: Antimicrob. Agents Chemother., 38, 653 (1994), Reichard, O., et al.: Lancet, 351, 83 (1998)<br></p>Fórmula:C3H4N4OForma y color:Off White SolidPeso molecular:112.09Decarboxylated S-Adenosylmethionine Sulfate Salt
CAS:<p>Stability Hygroscopic<br>Applications Decarboxylated S-Adenosylmethionine Sulfate Salt, is a substrate that is involved in the biosynthesis of polyamines including spermidine, spermine, and thermospermine.<br>References Takahashi,T., et al.: Ann. Bot., 105, 1 (2009); Wu, H., et al.: Biochem., 46, 8331 (2007); Pegg, A., et al.: Biochem., 28, 8446 (1989);<br></p>Fórmula:C14H23N6O3S•H2SO4•HSO4Forma y color:White SolidPeso molecular:355.4498079706Ammeline
CAS:<p>Applications Ammeline is a metabolite of Melamine (1) (M208700), which acts as a non-protein nitrogen food additive (2). Also present in pet foods as well (3).Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA). Environmental contaminants; Food contaminants.<br>References 1. Mast RW. et al.: Food Chem Toxicol. 1983 Dec;21(6):807-10.2. Ehling S. et al.: Food Addit Contam. 2007 Dec;24(12):1319-25.3. Vail T. et al.: J Anal Toxicol. 2007 Jul-Aug;31(6):304-12.<br></p>Fórmula:C3H5N5OForma y color:ColourlessPeso molecular:127.103'-Azido-3'-deoxythymidine
CAS:Producto controlado<p>Applications A potent and selective inhibitor of HIV-1 replication.<br>References Mitsuya, H., et al.: Nature, 325, 773 (1987), Brehm, J., et al.: Biochem., 47, 14020 (2008), Paredes, R., et al.: J. Virol., 83, 2038 (2009), Wan, J., et al.: J. Med. Chem., 52, 1144 (2009), Mainardes, R., et al.: J. Pharm. Sci., 98, 257 (2009),<br></p>Fórmula:C10H13N5O4Forma y color:White To YellowPeso molecular:267.245’-Deoxy-5-fluorocytidine-13C,15N2
CAS:Producto controlado<p>Applications A labelled metabolite of Capecitabine.<br></p>Fórmula:C813CH12FN15N2O4Forma y color:NeatPeso molecular:248.191-β-D-Arabinofuranosyluracil
CAS:<p>Impurity Cytarabine EP Impurity A<br>Applications Antiviral agent. Used for the treatment of severe acute respiratory syndrome (SARS).<br>References Weber, G., et al.: Cancer Res., 43, 3466 (1983), Broet, P., et al.: J. Clin. Oncol., 19, 2778 (2001), Galmarini, C., et al.: Leukemia, 15, 875 (2001), Barth, R., et al.: Cancer Res., 64, 6287 (2004), Song, M., et al.: Bioorg. Med. Chem., 12, 489 (2004),<br></p>Fórmula:C9H12N2O6Forma y color:WhitePeso molecular:244.20N-Methyltetrahydrofolic Acid
CAS:Producto controlado<p>Applications N-Methyltetrahydrofolic acid (cas# 134-35-0) is a useful research chemical.<br></p>Fórmula:C20H25N7O6Forma y color:NeatPeso molecular:459.46O-[(Guanin-9-yl)methyl] Acyclovir
CAS:<p>Impurity Aciclovir EP Impurity J<br>Applications O-(Guanin-9-yl)methyl Acyclovir (Aciclovir EP Impurity J) is a dimer impurity of the antiviral agent Acyclovir (A192400).<br>References Ashton, D.S. et al.: J. Chrom. A, 707, 367 (1995);<br></p>Fórmula:C14H16N10O4Forma y color:BeigePeso molecular:388.34D-2’-Deoxyribofuranosyl-3-guanylurea(α/β-Mixture)
CAS:Producto controlado<p>Stability Hygroscopic<br>Applications Hydrolytic impurity of D226730 and A796950 (decitabine)<br>References Beisler, Jj.A., et al.: J. Med. Chem., 21, 204 (1978),<br></p>Fórmula:C7H14N4O4Forma y color:NeatPeso molecular:218.2105Biopterin-d3
CAS:Producto controlado<p>Stability Hygroscopic<br>Applications Labelled Biopterin. A pteridine widely distributed in nature; naturally occurring as the L-erythro-form. Considered as a growth factor for some insects. Fluoresces with a blue color in alkaline solution.<br>References Klatt, P., et al.: J. Biol. Chem., 269, 13861 (1994), Mitnaul, L., et al.: Biochemistry, 92, 885 (1995), Thony, B., et al.: Biochem. J., 347, 1 (2000),<br></p>Fórmula:C92H3H8N5O3Forma y color:Beige To BrownPeso molecular:240.234-Amino-5-fluoro-1-(2,3-di-O-acetyl-α-D-ribofuranosyl)-2(1H)-pyrimidinone
CAS:<p>Applications 4-Amino-5-fluoro-1-(2,3-di-O-acetyl-α-D-ribofuranosyl)-2(1H)-pyrimidinone is an impurity of Capecitabine (C175650), which is an antineoplastic agent. Capecitabine is a prodrug of Doxifluridine (D556750).<br>References Muss, H., et al.: New Eng. J. Med., 360, 2055 (2009), Takahashi, S., et al.: Drug Metab. Disposition, 37, 956 (2009), Saltz, L., et al.: J. Clin. Oncol., 27, 653 (2009), Sanderson, H., et al.: Toxicol. Lett., 187, 84 (2009),<br></p>Fórmula:C13H16FN3O6Forma y color:Off White PowderPeso molecular:329.28(-)-Inosine
CAS:Producto controlado<p>Stability Hygroscopic<br>Applications Has neuroprotective properties improving axonal wiring. Has been used to treat stroke patients to restore neural function. Neuroprotective product.<br>References Vandemeulebroucke, A., et al.: Biochem., 49, 8999 (2010), Nestor, G., et al.: J. Agric. Food Chem., 58, 10799 (2010),<br></p>Fórmula:C10H12N4O5Forma y color:White To Off-WhitePeso molecular:268.235-Chloro-1-methyl-4-nitroimidazole
CAS:Producto controlado<p>Impurity Azathioprine EP Impurity C<br>Applications 5-Chloro-1-methyl-4-nitroimidazole (cas# 4897-25-0) is a compound useful in organic synthesis.<br></p>Fórmula:C4H4ClN3O2Forma y color:White To Off-WhitePeso molecular:161.551-(Diaminomethylene)-3-b-D-ribofuranosyl-urea Picrate
CAS:Producto controlado<p>Impurity Azacitidine USP Related Compound C<br>Stability Hygroscopic<br>Applications 1-(Diaminomethylene)-3-β-D-ribofuranosyl-urea Picrate is a related compound of Azacitidine, a DNA metnyltransferase (DNMT) inhibitor for treating myelodysplastic syndromes (MDS).<br>References Rajendiran, C., et al.: PCT Int. Appl. WO 2012135405 A1 20121004 (2012); Ziemba, A., et al.: Chemother Res Pract 965826, 9 (2011); Beisler, J. A., et al.: J. Carbohyd. Chem 4, 281 (1977)<br></p>Fórmula:C7H14N4O5·C6H3N3O7Forma y color:YellowPeso molecular:463.31N-Formyl Valacyclovir
CAS:Producto controlado<p>Impurity Valaciclovir EP Impurity M<br>Applications N-Formyl Valacyclovir (Valaciclovir EP Impurity M) Valacyclovir (V085000) impurity.<br>References Furman, P., et al.: Antimicrob. Agents Chemother., 20, 518 (1981),<br></p>Fórmula:C14H20N6O5Forma y color:White To Off-WhitePeso molecular:352.355’-Deoxy-5-fluorouridine
CAS:Producto controlado<p>Impurity USP Capecitabine Related Compound B<br>Applications 5’-Deoxy-5-fluorouridine is a metabolite of the chemotherapeutic agent Capecitabine (C175650). 5’-Deoxy-5-fluorouridine is an antitumor agent efficient in tumors, cell lines or in fibroblasts tranformed by H-ras or trk oncogenes.<br>References Ingle, J., et al.: Cancer, 67, 886 (1991); Harvey, J., et al.: J. Clin. Oncol., 17, 1474 (1999); Asai-Sato, M., et al.: Int. J. Cancer, 115, 539 (2005); Rastelli, F., et al.: Tumori, 94, 370 (2008);<br></p>Fórmula:C9H11FN2O5Forma y color:NeatPeso molecular:246.19Acetyl Vitamin B12
CAS:<p>Applications Acetyl Vitamin B12 is a derivative of Vitamin B12 (V676020). Vitamin B12 gets converted by the body into its bioactive forms, methylcobalamin and cobamamide, which serve as enzyme cofactors. Severe deficiency may result in megaloblastic anemia and/or neurological impairment.<br>References Rickes, et al.: Science, 107, 396 (1948); Kirschbaum, J., et al.: Anal. Profiles Drug Subs., 10, 183 (1981); Grasbeck, R., et al.: Clin. Biochem., 17, 99 (1984)<br></p>Fórmula:C65H90CoN14O15PPureza:>85%Forma y color:NeatPeso molecular:1397.405-Fluorouracil-13C,15N2
CAS:<p>Applications Labelled 5-FU, a potent antineoplastic agent in clinical use. Also an inhibitor of DNA synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Rudy, B.C., et al.: Anal. Profiles Drug Subs., 2, 221 (1973), Miyashita, O., et al.: Chem. Pharm. Bull., 29, 3181 (1981), Hansen, R.M., et al.: Cancer Invest., 9, 637 (1991),<br></p>Fórmula:C313CH3F15N2O2Forma y color:NeatPeso molecular:133.06Capecitabine-2',3'-cyclic Carbonate
CAS:Producto controlado<p>Impurity Capecitabine EP Impurity F/ USP Capecitabine Related Compound C<br>Applications Capecitabine-2',3'-cyclic Carbonate (Capecitabine EP Impurity F) is a capecitabine related compound C is an impurity in Capecitabine (C175650), an antineoplastic agent. Capecitabine is a prodrug of Doxifluridine (D556750).<br>References Muss, H., et al.: New Eng. J. Med., 360, 2055 (2009), Takahashi, S., et al.: Drug Metab. Disposition, 37, 956 (2009), Saltz, L., et al.: J. Clin. Oncol., 27, 653 (2009), Sanderson, H., et al.: Toxicol. Lett., 187, 84 (2009),<br></p>Fórmula:C16H20FN3O7Forma y color:NeatPeso molecular:385.34Emtricitabine Tenofovir Monosoproxil
Producto controlado<p>Stability Hygrscopic<br>Applications Emtricitabine Tenofovir Monosoproxil is a derivative of Emtricitabine (E525000). Emtricitabine is a reverse transcriptase inhibitor. It is an effective antiviral agent against HIV, HBV, and other viruses replicating in a similar manner.<br>References FASEB J., 13, 1511 (1999), Molina, J.-M., et al.: J. InfecSchinazi, R.F., et al.: Antimicrob. Ag. Chemother., 36, 2423 (1992), Shockeor, J.P., et al.: Xenobioica, 26, 189 (1996), Feng, J.Y., et al.: . Dis., 182, 599 (2000)<br></p>Fórmula:C23H32FN8O10PSForma y color:NeatPeso molecular:662.58Zalcitabine
CAS:Producto controlado<p>Applications A pyrimidine nucleoside analogue with antiviral activity.<br>References van der Vliet, P.C. and Kwant, M.M.: Biochemistry, 20, 2628 (1981), Mitsuya, H., Broder, S.: Proc. Nat. Acad. Sci. USA, 83, 1911 (1986), Starnes, M.C., and Cheng, Y.: J. Biol. Chem., 262, 988 (1987),<br></p>Fórmula:C9H13N3O3Forma y color:NeatPeso molecular:211.222-Deoxy-2,2-difluoro-D-erythro-ribofuranose-3,5-dibenzoate
CAS:Producto controlado<p>Applications Gemcitabine intermediate.<br>References Balzarini, J., et al.: Biochem. Pharmacol., 1988, 37, 2847 (1988), Hertel, L., et al.: Cancer Res., 50, 4417 (1990), Marquez, V., et al.: J. Med. Chem., 33, 978 (1990),<br></p>Fórmula:C19H16F2O6Forma y color:Colourless To BrownPeso molecular:378.32Lamivudine-13C1,d2
CAS:Producto controlado<p>Stability Hygroscopic<br>Applications Lamivudine-13C1,d2, is the labeled analogue of Lamivudine (L172502). A reverse transcriptase inhibitor. Antiviral.<br>References Morris, D.M., J. Pharm. Biomed. Anal., 12, 255 (1944), Nevens, B.F., et al.: Gastroenterology, 113, 1258 (1997), Perry, C.M., et al.: Drugs, 53, 657 (1977),<br></p>Fórmula:C713CH9D2N3O3SForma y color:White PowderPeso molecular:232.26Canagliflozin
CAS:Producto controlado<p>Applications Canagliflozin is a sodium/glucose cotransporter 2 (SGLT2) inhibitor. Canagliflozin has been shown to dose dependently reduce calculated renal threshold for glucose excretion and increase urinary glucose excretion. Canagliflozin is a candidate for the treatment of type 2 diabetes and obesity.<br>References Chao, E. et al.: Drug Fut., 36, 351 (2011); Sha, S. et al.: Diab. Obes. Metab., 13, 669 (2011); Kipnes, M.S.: Clin. Invest., 1, 145 (2011);<br></p>Fórmula:C24H25FO5SForma y color:ColourlessPeso molecular:444.52Lamivudine
CAS:Producto controlado<p>Applications Lamivudine is a potent nucleoside reverse transcriptase inhibitor. Antiviral. Lamivudine has been used for treatment of chronic hepatitis B.<br>References Morris, D.M., J. Pharm. Biomed. Anal., 12, 255 (1944), Nevens, B.F., et al.: Gastroenterology, 113, 1258 (1997), Perry, C.M., et al.: Drugs, 53, 657 (1977),<br></p>Fórmula:C8H11N3O3SForma y color:WhitePeso molecular:229.26Cobamamide
CAS:Producto controlado<p>Applications Cobamamide is an enzyme cofactor that can also regulate gene expression through RNA-base riboswitches.<br>References Ortiz-Guerrero, J.M., et. al.: P. Natl. Acad. Sci. USA, 108, 7565 (2011)<br></p>Fórmula:C72H100CoN18O17PForma y color:NeatPeso molecular:1579.585-Hydroxy-1-methyl-4-nitroimidazole Sodium Salt (>90%)
CAS:Producto controlado<p>Impurity Azathioprine BP Impurity E<br>Stability Light Sensitive<br>Applications 5-Hydroxy-1-methyl-4-nitroimidazole Sodium Salt is a degradation product of Azathioprine (A803350); an immunosuppressive antimetabolite that is also active as a disease modifying antirheumatic drug (DMARD).<br>References Mitrou, P.S., et al.: Arzneim.-Forsch., 29, 483, 662 (1979); Ding, T.L., et al.: Drug. Metab. Dispos., 7, 373 (1979); Chan, G.L.C., et al.: Pharmacotherapy, 7, 165 (1987); Sandborn, W.J., et al.: Scand. J. Gastroenterol., 33, Suppl. 225, 92 (1998)<br></p>Fórmula:C4H4N3NaO3Pureza:>90%Forma y color:Light Yellow To YellowPeso molecular:165.085-Chlorouracil
CAS:Producto controlado<p>Impurity Fluorouracil EP Impurity E<br>Applications Used for the experimental and clinical treatment of neoplastic and viral diseases. Fluorouracil EP Impurity E.<br>References Yu, H., et al.: J. Biol. Chem., 268, 15935 (1993), Staleva, L., et al.: Mutat. Res., 370, 81(1996), Harris, V., et al.: J. Mol. Biol., 326, 1389 (2003)<br></p>Fórmula:C4H3ClN2O2Forma y color:NeatPeso molecular:146.53Emtricitabine
CAS:<p>Applications A reverse transcriptase inhibitor. It is an effective antiviral agent against HIV, HBV, and other viruses replicating in a similar manner. A nucleoside analog structurally related to Lamivudine (L172500).<br>References FASEB J., 13, 1511 (1999), Molina, J.-M., et al.: J. InfecSchinazi, R.F., et al.: Antimicrob. Ag. Chemother., 36, 2423 (1992), Shockeor, J.P., et al.: Xenobioica, 26, 189 (1996), Feng, J.Y., et al.: . Dis., 182, 599 (2000)<br></p>Fórmula:C8H10FN3O3SForma y color:Light YellowPeso molecular:247.25Adenosine-15N
CAS:Producto controlado<p>Applications Nitrogen 15 labelled analogue of Adenosine (A280400), a purine nucleoside that plays an important role in various biochemical processes.<br>References Long, X., et al.: J. Pharmacol. Exper. Ther., 335, 781 (2010); Ham, M., et al.: J. Pharmacol. Exper. Ther., 335, 607 (2010)<br></p>Fórmula:C10H1315NN4O4Forma y color:NeatPeso molecular:268.2352’,3’-Dideoxyinosine
CAS:Producto controlado<p>Applications 2’,3’-Dideoxyinosine is a purine analog (1) which used as an antiviral agent. Classed as an anti-retroviral drug used in the treatment of HIV in ART therapy, it also may increase acetaminophen related hepatotoxicity by enhancing mitochrondrial dysfunction (2).<br>References 1. Esplugues, J. et al.: AIDS. 2016 Jun 1;30(9):1341-51.2. Blas-Garcia, A. et al.: J. Antimicrob. Chemother. 2016 Apr;71(4):916-26<br></p>Fórmula:C10H12N4O3Forma y color:NeatPeso molecular:236.23Cladribine
CAS:<p>Applications It is a substituted purine nucleoside with antileukemic activity.<br>References Seto, S., et al.: J. Clin. Invest., 75, 377 (1985), Piro, L.D., et al.: N. Engl. J. Med., 322, 1117 (1990);<br></p>Fórmula:C10H12ClN5O3Forma y color:White To Light YellowPeso molecular:285.692'-Deoxyadenosine Monohydrate
CAS:Producto controlado<p>Applications 2'-Deoxyadenosine Monohydrate is used in the synthesis of 5'-modified 2'-deoxyadenosine analogues as anti-hepatitis C virus agents.<br>References Gordon, C., et al.: J. Med. Chem., 48, 1 (2005), Ikejiri, M., et al.: Bioorg. Med. Chem., 15, 6882 (2007),<br></p>Fórmula:C10H13N5O3·H2OForma y color:NeatPeso molecular:269.26Coenzyme Q9
CAS:<p>Applications Antibacterial and antioxidant for preventing and treating cancer.<br>References Itoh, K., et al.: J. Immunol., 170, 3688 (2003), Liu, A., et al.: J. Biol. Chem., 279, 53196 (2004), Wullaert, A., et al.: Biochem. Pharmacol., 72, 1090 (2006),<br></p>Fórmula:C54H82O4Forma y color:YellowPeso molecular:795.23(2R,3R,4S,5R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile
CAS:<p>Applications (2R,3R,4S,5R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile is a predominant metabolite of remdesivir with great potential for Covid-19 treatment.<br>References Yan, V. C., et al.: ACS Med. Chem., 11, 1361 (2020)<br></p>Fórmula:C12H13N5O4Forma y color:NeatPeso molecular:291.26274’,6-Diamidino-2-phenylindole Dihydrochloride
CAS:Producto controlado<p>Stability Hygroscopic<br>Applications A cell-permeable DNA-binding dye. Binds preferentially to DNA rich in adenine and thymine. Used in flow cytometry for measuring nuclear DNA content or for sorting isolated chromosomes.<br>References Jpeeesen, C, and Nielsen, P.E.: Eur. J. Biochem., 182, 437 (1989), Li,J., et al.: J. Exp. Biol., 200, 1499 (1997), Zaitsev, E.N., and Kowalczykowsi, S.C.: Nucl. Acids Res., 26(2), 650 (1998), Germ, M., et al.: Biochem. Biophys. Res. Commun., 261, 452 (1999),<br></p>Fórmula:C16H15N5·2ClHForma y color:Yellow PowderPeso molecular:350.25Dapagliflozin C2 Epimer
CAS:Producto controlado<p>Stability Hygroscopic<br>Applications Dapagliflozin C2 Epimer is an intermediate used in the synthesis of Dapagliflozin (D185370), a sodium-glucose transporter 2 inhibitor.<br>References Majewski, A., et al.: Przemysl Chemiczny, 95, 1129 (2016); Kasichayanula, S. et al.: Diabetes, Obesity and Metabolism 13, 47 (2011)<br></p>Fórmula:C21H25ClO6Forma y color:NeatPeso molecular:408.87Dapagliflozin Methyl Acetate
CAS:Producto controlado<p>Applications Dapagliflozin Methyl Acetate is the impurity of Dapagliflozin (D185370), which is a sodium-glucose transporter 2 inhibitor.<br>References Kasichayanula, S. et al.: Diabetes, Obesity and Metabolism 13, 47 (2011)<br></p>Fórmula:C23H27ClO7Forma y color:NeatPeso molecular:450.909Triethyl Methanetricarboxylate
CAS:Producto controlado<p>Applications Triethyl Methanetricarboxylate is used in the synthesis of novel inhibitors of Hsp90. It is also used in the preparation of novel dihydroquinoline-3-carboxylic acids that function as HIV-1 integrase inhibitors.<br>References Day, J. et al.: Chem. A Eur. J., 16, 2758 (2010); Sechi, M. et al.: Bioorg. Med. Chem., 17, 2925 (2009);<br></p>Fórmula:C10H16O6Forma y color:NeatPeso molecular:232.23Ammeline-13C3 Hydrochloride
CAS:Producto controlado<p>Stability Hygroscopic<br>Applications Isotope labelled Ammeline (A633660), which s a metabolite of Melamine (1) (M208700), which acts as a non-protein nitrogen food additive (2). Also present in pet foods as well (3). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA). Environmental contaminants; Food contaminants.<br>References 1. Mast RW. et al.: Food Chem Toxicol. 1983 Dec;21(6):807-10.2. Ehling S. et al.: Food Addit Contam. 2007 Dec;24(12):1319-25.3. Vail T. et al.: J Anal Toxicol. 2007 Jul-Aug;31(6):304-12.<br></p>Fórmula:C3H5N5O·ClHForma y color:NeatPeso molecular:166.54Adenosine-5'-13C
CAS:Producto controlado<p>Applications Carbon 13 Labelled analogue of Adenosine (A280400), a purine nucleoside that plays an important role in various biochemical processes.<br>References Long, X., et al.: J. Pharmacol. Exper. Ther., 335, 781 (2010); Ham, M., et al.: J. Pharmacol. Exper. Ther., 335, 607 (2010)<br></p>Fórmula:C913CH13N5O4Forma y color:NeatPeso molecular:268.24Penciclovir-d4
CAS:Producto controlado<p>Applications A deuterated version of Penciclovir, an antiviral.<br>References Weinberg, A., et al.: Antimicrob. Ag. Chemother., 36, 2037 (1992), McMeekin, J.R., et al.: Anal. Proc., 29, 178 (1992),<br></p>Fórmula:C102H4H11N5O3Forma y color:NeatPeso molecular:257.28Ribavirin Carboxylic Acid
CAS:<p>Impurity USP Ribavirin Related Compound A<br>Applications Ribavirin Carboxylic acid is an impurity of Ribavirin (R414475). Ribavirin impurity A.<br>References Lertora, J., et al.: Clin. Pharmacol. Ther., 50, 442 (1991), Connor, E., et al.: Antimicrob. Agents Chemother., 37, 532 (1993), Manns, M., et al.: Lancet, 358, 958 (2001),<br></p>Fórmula:C8H11N3O6Forma y color:NeatPeso molecular:245.19Adenosine-5',5''-d2
CAS:Producto controlado<p>Applications Labelled analogue of Adenosine (A280400), a purine nucleoside that plays an important role in various biochemical processes.<br>References Long, X., et al.: J. Pharmacol. Exper. Ther., 335, 781 (2010); Ham, M., et al.: J. Pharmacol. Exper. Ther., 335, 607 (2010)<br></p>Fórmula:C10H11D2N5O4Forma y color:White SolidPeso molecular:269.26Abacavir Carboxylate
CAS:<p>Impurity Abacavir - In House Impurity<br>Stability Hygroscopic<br>Applications Abacavir Carboxylate (Abacavir - In House Impurity) is a major metabolite of Abacavir (A105000) in human urine and cerebrospinal fluid (1,2,3).<br>References (1) Hoetelmans, R., et al.: Pharm. World Sci., 19, 159 (1997) (2) Beach, J., et al.: Clin. Ther., 20, 2 (1998) (3) McDowell, J., et al.: Antimicrob. Agents Chemother., 43, 2855 (1999)<br></p>Fórmula:C14H16N6O2Forma y color:NeatPeso molecular:300.32L-Valacyclovir Hydrochloride
CAS:Producto controlado<p>Applications Acyclovir (A192400) impurity. The L-Valine ester prodrug of Acyclovir.<br>References Beauchamp, L.M., et al.: Antiviral Chem. Chemother., 3, 157 (1992), Weller, S., et al.: Clin. Pharmacol. Ther., 54, 595 (1996), Lowance, D., et al.: N. Engl. J. Med., 340, 1462 (1999),<br></p>Fórmula:C13H20N6O4·ClHForma y color:White To Off-WhitePeso molecular:360.80Famciclovir-d4
CAS:Producto controlado<p>Applications A deuterated prodrug of Penciclovir (P221500), which is used as an antiviral.<br>References Hodge, V.R.A., et al.: Antimicrob. Ag. Chemother., 33, 1765 (1989),<br></p>Fórmula:C142H4H15N5O4Forma y color:Off-White To Light BeigePeso molecular:325.36N6-Isopentenyladenosine
CAS:<p>Applications N6-Isopentenyladenosine has antiproliferative activity on MCF-7 breast cancer cells.<br>References Rajabi, M. et al.; DNA Cell Biol.; 29, 687 (2010)<br></p>Fórmula:C15H21N5O4Forma y color:NeatPeso molecular:335.365-Fluorodihydropyrimidine-2,4-dione-13C,15N2
CAS:Producto controlado<p>Applications A labelled metabolite of 5-Fluorouracil (F596000).<br>References Bocci, G., et al.: Eur. J. Clin. Pharmacol., 58, 593 (2002), Longley, D.B., Nature Rev. Cancer, 3, 330 (2003), Fischel, J., et al.: Anti-Cancer Drugs, 15, 969 (2004)<br></p>Fórmula:C313CH5F15N2O2Forma y color:Off-White To Light BrownPeso molecular:135.071-α-Methyl Dapagliflozin
CAS:<p>Stability Hygroscopic<br>Applications 1α-Methyl Dapagliflozin is an antidiabetic agent and intermediate of Dapagliflozin (D226255]), a sodium-glucose transporter 2 inhibitor.<br>References Kasichayanula, S. et al.: Diabetes, Obesity and Metabolism 13, 47 (2011); Bernhardson, D. et al.: Org. Proc. Res. Dev., 18, 57 (2014);<br></p>Fórmula:C22H27ClO7Forma y color:WhitePeso molecular:438.90Dapagliflozin
CAS:<p>Stability Hygroscopic<br>Applications A sodium-glucose transporter 2 inhibitor.<br>References Kasichayanula, S. et al.: Diabetes, Obesity and Metabolism 13, 47 (2011)<br></p>Fórmula:C21H25ClO6Forma y color:NeatPeso molecular:408.87Ribavirin 5’-Monophosphate Dilithium Salt (90%)
CAS:Producto controlado<p>Applications A metabolite of Ribavirin.<br>References Allen, L.B., et al.: J. Med. Chem., 21, 742 (1978), Zimmerman, T., et al.: Biochem. Pharmacol., 27, 709 (1978), Page, T., et al.: Int. J. Biochem., 22, 379 (1990), Lin, C., et al.: Antimicrob. Agents Chemother., 47, 1395 (2003),<br></p>Fórmula:C17H19N4O9P·2LiPureza:90%Forma y color:Off-White To Light BeigePeso molecular:468.21O6-Benzylguanine
CAS:Producto controlado<p>Applications An irreversible inhibitor of the mammalian DNA repair protein, O6-alkylguanine-DNA alkyltransferase. Assists in the protection against carcinogenic and therapeutic alkylating agents.<br>References Dolan, M.E., et al.: Proc. Natl. Acad. Sci. USA, 87, 5356 (1990), Goodtzova, K., et al.: Biochemistry, 33, 385 (1994), Elder, R.H., et al.: Biochem. J., 298, 231 (1994)<br></p>Fórmula:C12H11N5OForma y color:NeatPeso molecular:241.25α-Ribavirin (Ribavirin Impurity B)
CAS:Producto controladoFórmula:C8H12N4O5Forma y color:NeatPeso molecular:244.203'-Azido-3'-deoxythymidine β-D-glucuronide, Sodium Salt
CAS:Producto controlado<p>Stability Hygroscopic<br>Applications A metabolite of the potent and selective inhibitor of HIV-1 replication, AZT.<br></p>Fórmula:C16H20N5O10·NaForma y color:White To Light YellowPeso molecular:465.35Cabotegravir O-β-D-Glucuronide
CAS:Producto controlado<p>Applications Cabotegravir O-β-D-Glucuronide is a metabolite of Cabotegravir (C050100), a long acting HIV-1 integrase inhibitor with action against a broad range of HIV subtypes.<br>References Yoshinaga, T. et al.: Antimicrob, Agents Chemother., 59, 397 (2015); Andrews, C. et al.: Sci. Transl. Med., 7, 270 (2015)<br></p>Fórmula:C25H25F2N3O11Pureza:>80%Forma y color:NeatPeso molecular:581.48Acyclovir Formacetal Dimer (>90%)
<p>Impurity Aciclovir EP Impurity R<br>Applications Acyclovir Formacetal Dimer is a dimer impurity of Acyclovir (A192400); an orally active acyclic nucleoside with inhibitory activity towards several herpes viruses. Also antiviral. (Aciclovir EP Impurity R)<br>References Collins, P., et al.: J. Antimicrob. Chemother., 5, 431 (1979); Matsumoto, H., et al.: Chem. Pharm. Bull., 36, 1153 (1988); Whitley, R.J., et al.: N. Engl. J. Med., 327, 782 (1992)<br></p>Fórmula:C17H22N10O6Pureza:>90%Forma y color:NeatPeso molecular:462.422’-Deoxyadenosine
CAS:<p>Applications 2prime-Deoxyadenosine is a nucleoside adenosine derivative with mutagenic properties.<br></p>Fórmula:C10H13N5O3Forma y color:White To Off-WhitePeso molecular:251.242N-Nitrosodiethylamine (100 ug/mL in Methanol)
CAS:Producto controladoFórmula:C4H10N2OForma y color:Single SolutionPeso molecular:102.14Famciclovir
CAS:Producto controlado<p>Applications Used as an antiviral. Prodrug of Penciclovir (P221500).<br>References Hodge, V.R.A., et al.: Antimicrob. Ag. Chemother., 33, 1765 (1989),<br></p>Fórmula:C14H19N5O4Forma y color:Off-WhitePeso molecular:321.33Coenzyme A Trilithium Salt
CAS:<p>Stability Hygroscopic<br>Applications A cofactor in enzymatic acetyl transfer reactions. It is the source of the phosphopantetheine group that is added as a prosthetic group to proteins such as acyl carrier protein and formyltetrahydrofolate dehydrogenase.<br>References Strickland K.C. et al.: J. Biol. Chem., 285, 1627 (2010); Elovson J. et al.: J. Biol. Chem., 243, 3603 (1968);<br></p>Fórmula:C21H33N7O16P3S·3LiForma y color:NeatPeso molecular:785.33Ribavirin-13C5
CAS:Producto controlado<p>Stability Hygroscopic<br>Applications Labelled Ribavirin (R414475). Purine nucleoside analog; inhibits inosine monophosphate dehydrogenase (IMPDH). Used as an antiviral agent.This compound is suitable for pyruvate dehydrogenase (PDH) related research.<br>References Fernandez, H., et al.: Eur. J. Epidemiol., 2, 1 (1986), Liao, H.J. and Stollar, V.: Antiviral Res., 22, 285 (1993), Honda, Y., et al.: Antimicrob. Agents Chemother., 38, 653 (1994), Reichard, O., et al.: Lancet, 351, 83 (1998)<br></p>Fórmula:C5C3H12N4O5Forma y color:NeatPeso molecular:249.17Flavine Adenine Dinucleotide Disodium Salt
CAS:Producto controlado<p>Stability Hygroscopic<br>Applications The prosthetic group of certain flavoproteins including D-amino acid oxidase, glucose oxidase, glycine oxidase, fumaric hydrogenase, histaminase, and xanthine oxidase. Riboflavin kinase tumor necrosis factor receptor 1 NADPH oxidase.<br>References DeLuca, K., et al.: J. Biol. Chem., 223, 569 (1956), Yagi, K., et al.: Biochemistry, 19, 1553 (1980), Li, G., et al.: J. Phys. Chem., 112, 4573 (2008),<br></p>Fórmula:C27H31N9O15P2·2NaForma y color:NeatPeso molecular:829.516,6'-Thiobis-9H-purine
CAS:Producto controlado<p>Applications 6,6'-Thiobis-9H-purine is used in the study of the activity of topoisomerase IIα.<br>References Jensen, L.H., et al.: Molecular Pharmacology, 70, 1503 (2006);<br></p>Fórmula:C10H6N8SForma y color:NeatPeso molecular:270.27Adenosine-1'-13C
CAS:Producto controladoFórmula:CC9H13N5O4Forma y color:White To Off-WhitePeso molecular:268.234Adenosine 5'-Triphosphate Disodium Salt
CAS:<p>Stability Hygroscopic, Temperature Sensitive<br>Applications A metabolite of Adenosine (A280400), a multifunctional nucleoside triphosphate used in cells as a coenzyme of intracellular energy transfer. It transports chemical energy within cells for metabolism.<br>References Knowles, J., et al.: Annu. Rev. Biochem., 49, 877 (1980),<br></p>Fórmula:C10H14N5O13P3·2NaForma y color:NeatPeso molecular:569.162’-Deoxy Cytidine-5,6-d2
CAS:Producto controladoFórmula:C9D2H11N3O4Forma y color:NeatPeso molecular:229.23
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