Sales y derivados de API
Las sales de los Ingredientes Farmacéuticos Activos (API) son compuestos formados por la reacción de un ácido con una base, resultando en un equilibrio iónico. Estas sales suelen mejorar la solubilidad y estabilidad de los APIs, facilitando su absorción en el cuerpo. Los derivados de API son variantes químicas de un principio activo que pueden tener propiedades mejoradas o modificadas para optimizar su eficacia terapéutica. Las sales de APIs se utilizan en la formulación de medicamentos orales, inyectables y tópicos. Además, los derivados de APIs pueden mejorar la farmacocinética de los fármacos, como la liberación controlada de activos.
En CymitQuimica contamos con sales y derivados de APIs con la pureza y calidad necesarias para investigación y desarrollo de formulaciones farmacéuticas.
Se han encontrado 79464 productos de "Sales y derivados de API"
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5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic Acid Hydrochloride
CAS:Producto controlado<p>Stability Hygroscopic<br>Applications 5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic Acid Hydrochloride is used as a reagent in the synthesis of N-(2-acylaminobenzyl or 2-acylaminoheterocyclylmethyl)thiophene-2-carboxamide derivatives as antithrombotics. It is also used as a reagent in the synthesis of diamide derivatives as FXa inhibitors. 5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic Acid Hydrochloride is an intermediate for Edoxaban (E555520).<br>References Mochizuki, A., et al.: Jpn. Kokai Tokkyo Koho. JP 2010120852 A 20100603. Jun 3, 2010; Mochizuki, A., et al.: PCT Int. Appl. WO 2008123017 A1 20081016. Oct 16, 2008<br></p>Fórmula:C8H11ClN2O2SForma y color:Light BrownPeso molecular:234.7Selexipag
CAS:Producto controlado<p>Applications Selexipag is an orally available, highly selective, long-acting prostacyclin (IP) receptor agonist prodrug. It is a potential drug for the treatment of various vascular disorders such as pulmonary arterial hypertension and arteriosclerosis obliterans.<br>References Kuwano, K., et al.: J. Pharm. Exp. Ther., 322, 1181 (2007);<br></p>Fórmula:C26H32N4O4SForma y color:Light YellowPeso molecular:496.62Bosentan-d4
CAS:Producto controlado<p>Applications Labelled Bosentan (B675900). A mixed endothelin receptor antagonist. Used as a vasodilator. Antihypertensive.<br>References Clozel, M., et al.: J. Pharmacol. Exp. Ther., 270, 228 (1994), Gutsch, G., et al.: Cardiovasc. Drugs Ther., 10, 717 (1996), Weber, C., et al.: Clin Pharmacol. Ther., 60, 124 (1996), Krum, H., et al.: N. Engl. J. Med., 338, 784 (1998)<br></p>Fórmula:C27H25D4N5O6SForma y color:NeatPeso molecular:555.64Ethyl 2-(3-Formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate
CAS:Fórmula:C14H13NO4SForma y color:NeatPeso molecular:291.323”-O-Demethyl Ivermectin
CAS:<p>Applications 3”-O-Demethyl Ivermectin is an impurity of Ivermectin (I940800), an antiparasitic drug that is active against a wide variety of nematode and arthropod parasites and is used to treat scabies and lice in humans. An invitro inhibitor of SARS-CoV-2/ Covid-19.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Campbell, W., et al.: Science, 221, 823 (1983); Glaziou, P., et al.: Trop. Med. Parasitol., 45, 253 (1994); Meinking, T., et al.: New Engl. J. Med., 333, 26 (1995); Caly, L., et al.: Antivir. Res., 178<br></p>Fórmula:C47H72O14Forma y color:NeatPeso molecular:861.07Bimatoprost-d5
CAS:Producto controlado<p>Applications Labelled Bimatoprost (B386800). Bimatoprost is an antiglaucoma agent. Bimatoprost is an synthetic prostamide; structurally related to prostaglandin F2α.<br>References Brandt, J.D., et al.: Ophthalmology, 108, 1023 (2001), Woodward, D.F., et al.: J. Pharmacol. Exp. Ther., 305, 772 (2003), Quinones, R., et al.: J. Ocul. Pharmacol. Ther., 20, 115 (2004),<br></p>Fórmula:C25H32D5NO4Forma y color:NeatPeso molecular:420.6Tolvaptan-d7
CAS:Producto controlado<p>Applications Labelled Tolvaptan. It is a selective, competitive arginine vasopressin V2 receptor antagonist used to treat hyponatremia (low blood sodium levels) associated with congestive heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone (SIADH).<br>References Paterna, S., et al.: Eur. J. Heart Fail, 2, 305 (2000), Udelson, J., et al.: Circulation, 104, 2417 (2001), Goldsmith, S., et al.: J. Am. Coll Cardiol., 46, 1785 (2005), Schrier, R., et al.: N. Engl. J. Med., 355, 2099 (2006),<br></p>Fórmula:C26H18D7ClN2O3Forma y color:NeatPeso molecular:455.982,5-Ethyl Acetate Febuxostat
CAS:Producto controlado<p>Applications Febuxostat (F229000) is the parent compound for 2,5-Ethyl Acetate Febuxostat. Used for treatment of hyperuricemia and chronic gout. 40-120 mg/day febuxostat was proven effective in lowering serum urate levels when administered to manage hyperuricemia in patients with gout.<br>References Osada, Y., et al.: Eur. J. Pharmacol., 241, 183 (1993), Okamoto, K., et al.: J. Biol. Chem., 278, 1848 (2003), Mayer, M.D., et al.: Am. J. Therap., 12, 22 (2005), Tomlinson, B., et al.: Curr. Opin. Invest. Drugs, 6, 1168 (2005),<br></p>Fórmula:C20H25NO5SForma y color:NeatPeso molecular:391.48methyl (Z)-1-acetyl-3-(methoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate
CAS:Fórmula:C20H17NO5Peso molecular:351.36Zephirol-d7
CAS:Producto controlado<p>Applications Labelled Zephirol. Quaternary ammonium composition to treat herpes, pseudomonas, staph, hepatitis and other infectious diseases.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Berr, S., et al.: J. Phys. Chem., 91, 4760 (1987), Jones, M., et al.: Eur. J. Pharm. Biopharm., 48, 101 (1999), Okano, L., et al.: Langmuir, 16, 3119 (2000),<br></p>Fórmula:C21H31D7ClNForma y color:NeatPeso molecular:347.033’-Hydroxy Repaglinide (Mixture of Diastereomers)
CAS:Producto controlado<p>Applications A metabolite of Repaglinide (R144500).<br>References Jarvis, B., et al.: Drugs, 59, 891 (2000), Niemi, M., et al.: Clin. Pharmacol. Ther., 70, 58 (2001), Hatorp, V., et al.: Clin. Pharmacokinet., 41, 471 (2002), Walsky, R., et al.: Drug Metab. Dispos., 33, 413 (2005),<br></p>Fórmula:C27H36N2O5Forma y color:NeatPeso molecular:468.59Octenidine Dihydrochloride
CAS:Producto controlado<p>Stability Hygroscopic<br>Applications Octenidine is an antiseptic (topical). Octenidine is a cationic surfactant and bis-(dihydropyridinyl)-decane derivative.<br>References Slee, A.M., et al.: Antimicrob. Agents Chemother., 23, 531 (1983), Ghannoum, M.A., et al.: J. Antimicrob. Chemother., 25, 237 (1990), Allen, M., et al.: Microbiology, 152, 989 (2006), Ojha, A., et al.: Mol. Microbiol., 66, 468 (2007),<br></p>Fórmula:C36H62N4·2HClForma y color:White To Off-WhitePeso molecular:623.832-Fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoic acid
CAS:Fórmula:C16H11FN2O3Peso molecular:298.27Probenecid
CAS:Producto controlado<p>Applications Uricosuric.<br>References McKinney, S.E., et al.: J. Pharmacol. Exp. Ther., 102, 208 (1951), Israili, Z.H., et al.: J. Med. Chem., 15, 709 (1972), Al-Badr, A.A., et al.: Anal. Profiles Drug Subs., 10, 639 (1981), Cunningham, R.F., et al.: Clin. Pharmacokinet., 6, 135 (1981),<br></p>Fórmula:C13H19NO4SForma y color:WhitePeso molecular:285.36
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