APIs para investigación e impurezas
Los ingredientes farmacéuticos activos (API) son las sustancias en los medicamentos responsables de sus efectos terapéuticos. En esta sección, encontrarás una amplia variedad de API destinados a uso en investigación. Estos compuestos son esenciales para el desarrollo, prueba y validación de nuevas formulaciones farmacéuticas. En CymitQuimica, ofrecemos API de alta calidad para apoyar la investigación en el descubrimiento y desarrollo de fármacos.
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Se han encontrado 66910 productos de "APIs para investigación e impurezas"
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Sitagliptin keto amide impurity
CAS:Sitagliptin Keto Amide Impurity is a research and development impurity standard that has been shown to be an impurity in the drug product Sitagliptin. It is a synthetic, analytical impurity that has been shown to be present in the drug product at 0.1% of the total weight. This impurity is soluble in water and ethanol, but insoluble in ether, chloroform, benzene, and dichloromethane. The CAS number for this compound is 764667-65-4. Sitagliptin Keto Amide Impurity can be used as an analytical reference material or as a pharmacopoeia reference standard for HPLC analysis of sitagliptin keto amide and its metabolites.
Fórmula:C16H12F6N4O2Pureza:Min. 95%Forma y color:Slightly Yellow PowderPeso molecular:406.28 g/mol(R)-3-Methyl-1-(pyrazine- 2-carboxamido)butylboronic acid
The compound is a drug product, analytical, and research material. The molecule has been synthesized and purified by the company's chemists. It is not an API impurity but an impurity standard for HPLC. This compound is a synthetic chemical that does not occur naturally in any living organism. It has been developed for use in drug development and research. The compound was custom synthesized by the company's chemists to meet customer demand for high purity standards of this compound. It is used as a pharmacopoeia standard for HPLC analysis and drug development.Pureza:Min. 95%2-Methyl-10-(2-nitrophenyl)-10H-benzo[b]thieno[2,3-e] [1,4]diazepin-4-amine
2-Methyl-10-(2-nitrophenyl)-10H-benzo[b]thieno[2,3-e][1,4]diazepin-4-amine is an analytical standard for HPLC. It is a research and development chemical and should be handled with care. 2-Methyl-10-(2-nitrophenyl)-10H-benzo[b]thieno[2,3-e][1,4]diazepin-4-amine is a drug development API impurity that can be found in the drug product. Impurities standards are available for this compound. The CAS number for 2 methyl 10 (2 nitrophenyl) 10H benzo [b] thieno [2,3 - e][1,4] diazepin 4 amine is 71437–05–9.Pureza:Min. 95%O3-Desethyl apremilast
CAS:O3-Desethyl apremilast is an experimental drug product that belongs to the class of drug products. This drug product has been shown to be a natural, synthetic and analytical impurity in API. It is also an impurity standard for HPLC analysis. O3-Desethyl apremilast can be used in research and development, as well as niche applications in the pharmaceutical industry.
Fórmula:C20H20N2O7SPureza:Min. 95%Forma y color:PowderPeso molecular:432.45 g/mol(S)-Duloxetine succinamide
CAS:Duloxetine succinamide is a chromatographic, solid, acidic compound. It has been synthesized by reacting (S)-duloxetine hydrochloride with succinic anhydride in the presence of triethylamine and acetonitrile. The reaction mixture was purified by high-performance liquid chromatography to produce the desired product. The purity of the compound was confirmed by postulating that it should have a reversed-phase HPLC profile similar to that of duloxetine succinate. Duloxetine succinamide is not soluble in water and is insoluble in organic solvents such as acetone, chloroform, ether, or benzene. The compound is stable at room temperature but decomposes when heated at higher temperatures. !--Fórmula:C22H23NO4SPureza:Min. 95%Forma y color:PowderPeso molecular:397.49 g/mol2'-Nor thiaMine
CAS:2'-Nor thiaMine is a drug product, analytical and impurity standard for the manufacture of pharmaceuticals. It is a natural substance found in plants, animals and humans. 2'-Nor thiaMine has been shown to be an impurity of the drug 2-mercaptopurine (2MP), which is used to treat leukemia, lymphoma and psoriasis. This compound can also be used as a research tool or as an impurity standard. 2'-Nor thiaMine is used in metabolism studies of drugs that are metabolized by liver enzymes such as cytochrome P450. It has been shown to inhibit the activity of these enzymes in vitro at concentrations less than 1 μM. CAS No.: 7770-93-6Fórmula:C11H15ClN4OSPureza:Min. 95%Peso molecular:286.78 g/mol4-(Aminomethyl)-1-cyclohexene-1-carboxylic acid
CAS:4-(Aminomethyl)-1-cyclohexene-1-carboxylic acid is an antifibrinolytic agent that can be used to control bleeding. It is a carboxymethyl cellulose with a menthol flavour and it stabilizes the hemostatic effect of tranexamic acid. 4-(Aminomethyl)-1-cyclohexene-1-carboxylic acid has been shown to be effective in controlling bleeding in patients with disorders such as hemophilia and von Willebrand disease. The drug is stable in acidic compositions, making it useful for dental applications as well.Fórmula:C8H13NO2Pureza:Min. 95%Forma y color:White PowderPeso molecular:155.19 g/molApixaban Impurity 2
CAS:Apixaban impurity 2 is a drug product that is used as an impurity standard in the research and development of drugs. It is also used as a synthetic intermediate in the synthesis of other drugs. Apixaban impurity 2 has been shown to be pharmacologically active, with the ability to inhibit bacterial growth by binding to DNA-dependent RNA polymerase. This compound is not toxic to mammalian cells at high concentrations, but has been shown to have some effects on the central nervous system, including depression of spontaneous motor activity and decrease in locomotor activity. Apixaban Impurity 2 is soluble in acetone and chloroform, but insoluble in water. The molecular weight of this compound is not known, but it can be determined using HPLC. Apixaban Impurity 2 has CAS number 2187409-01-2 and its molecular formula is C21H22N2O4S.Fórmula:C25H28N6O4Pureza:Min. 95%Forma y color:PowderPeso molecular:476.53 g/molDihydro-α-ergocryptine mesylate
CAS:Dihydro-alpha-ergocryptine mesylate is a drug that inhibits the effects of ergotamine and other drugs. It is used in animals to treat drug reactions, such as those caused by morphine and penicillin. Dihydro-alpha-ergocryptine mesylate can be detected in urine samples for up to 72 hours after administration. The pharmacokinetic properties of this drug are not well understood, but there is a linear relationship between dose and plasma concentration. The clinical response to dihydro-alpha-ergocryptine mesylate has been shown to be dose dependent. This drug also has dopaminergic properties, which may be due to its ability to bind with dopamine receptors in the central nervous system. There are several symptoms that may be related to taking this drug, including drowsiness or fatigue, nausea or vomiting, dry mouth, muscle spasms, and involuntary shaking of a part of the body (tremor).Fórmula:C33H47N5O8SPureza:Min. 95%Peso molecular:673.82 g/molMethyl 5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylate, racemic
CAS:Methyl 5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylate is a particle that is used to treat cardiac arrhythmias. It has been shown to be effective as an antipyretic agent and may also have analgesic properties. Methyl 5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylate is a white powder that melts at temperatures of about 300°C. This drug can be administered by inhalation in the form of a vaporized liquid. The particle size of this drug is typically less than 10 microns in diameter. Methyl 5-benzoyl-2,3-dihydro-1H pyrrolizine 1 carboxylate can be administered through the respiratory tract as an aerosol or nebulizer. The molecular weight of thisFórmula:C16H15NO3Pureza:Min. 98 Area-%Forma y color:PowderPeso molecular:269.3 g/mol6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5(2H,4H)-dione
CAS:6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5(2H,4H)-dione is a chlorinating agent that converts alcohols to alkyl chlorides. It is used for the conversion of diazotizable aromatic compounds to diazo compounds. This compound has been shown to be neuroprotective in animal models and provides protection against glutamate excitotoxicity. 6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5(2H,4H)-dione also reacts with nitrite ions to form the corresponding nitroso derivatives. These derivatives can cause DNA damage and are mutagenic. 6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5(2H,4H)-dione has been shown to react with aminoguanidine to produce a chromatFórmula:C9H5Cl2N3O2Pureza:Min. 95%Forma y color:PowderPeso molecular:258.06 g/molLevonorgestrel EP Impurity O
CAS:Soluble in Chloroform & in Methanol Confirmed
Insoluble in WaterPureza:95.0% MinForma y color:Off White or Beige SolidPeso molecular:344.49Bis-[[2-[(diaminomethylene)amino]thiazol-4-yl]methyl]disulfide
CAS:Bis-[[2-[(diaminomethylene)amino]thiazol-4-yl]methyl]disulfide is a disulfide derivative of famotidine. It has been used as an analytical reagent for the determination of impurities in famotidine and other related compounds. Bis-[[2-[(diaminomethylene)amino]thiazol-4-yl]methyl]disulfide is soluble in methanol, ethanol and water, but not in acetone. The compound can be prepared by reacting 4-(dimethylamino)-1H-1,2,3-benzothiadiazole with 2-[(diaminomethylene)amino]-4-(N'-methoxycarbonylthio)benzaldehyde and then reductive amination with sodium bisulfite.
Fórmula:C10H14N8S4Pureza:Min. 95%Forma y color:PowderPeso molecular:374.54 g/mol3-O-Methyl L-DOPA monohydrate
CAS:Producto controlado3-O-Methyl L-DOPA monohydrate is a chromatographic method that is used to diagnose Parkinson's disease. The method separates the catechol-o-methyltransferase (COMT) from plasma samples, which converts dopamine to 3-O-methyl dopamine. The 3-O-methyl dopamine reacts with an electrochemical detector and overlapped peaks can be seen on the chromatogram. This analytical method can be used to detect low levels of dopamine in the blood and diagnose Parkinson's disease.Fórmula:C10H13NO4·H2OPureza:Min. 95%Forma y color:White PowderPeso molecular:229.23 g/molN,N-Dimethyl-2-(1-phenyl-1-(pyridin-4-yl)ethoxy)ethanamine
CAS:Producto controladoThe synthesis of N,N-dimethyl-2-(1-phenyl-1-(pyridin-4-yl)ethoxy)ethanamine is a two step process. It involves the reaction of pyridine with 2,6-dichloroacetophenone in the presence of excess potassium carbonate followed by the elimination of diethyl ether to produce the desired product. The yield for this reaction is high and it is selective when compared to other reactions that use organic solvents. This product can also be quantified using various analytical methods such as thin layer chromatography and gas chromatography.Fórmula:C17H22N2OPureza:Min. 95%Forma y color:Clear LiquidPeso molecular:270.37 g/molDes-His(1)-Semaglutide
Des-His(1)-semaglutide is a semaglutide-related impurity. This des-amino acid form has the histidine (His) amino acid from position 1 removed from the peptide chain. Semaglutide impurities are structurally related compounds that arise during synthesis, purification, or storage of semaglutide, a long-acting GLP-1 receptor agonist used for managing type 2 diabetes and obesity.Fórmula:C181H284N42O58Peso molecular:3,976.5 g/molSemaglutide Impurity 54 (D-Ala 18)
D-Ala(18)-Semaglutide is a semaglutide impurity. The amino acid at position 18 has been replaced by the D-form of the amino acid D-alanine (D-Ala). Semaglutide impurities are structurally related compounds that arise during synthesis, purification, or storage of semaglutide, a long-acting GLP-1 receptor agonist for managing type 2 diabetes and obesity.Fórmula:C187H291N45O59Peso molecular:4,113.64 g/molDideiodo amiodarone
CAS:Producto controladoDideiodo amiodarone is a noncompetitive inhibitor of the enzyme, which is expressed in the human heart. It has been shown to interact with the benzofuran derivatives that are responsible for the antiarrhythmic effects of amiodarone. The inhibitory potency of dideiodo amiodarone is dose-dependent and constant. This drug has shown no competitive inhibition against any other analogs, such as quinidine or digitoxin. Dideiodo amiodarone inhibits the enzyme by binding to an allosteric site on the enzyme molecule. This site does not bind any other analogs, such as quinidine or digitoxin, and therefore it does not compete for this site.Fórmula:C25H31NO3Pureza:Min. 95%Forma y color:Clear LiquidPeso molecular:393.52 g/molFluticasone propionate EP Impurity F
CAS:Fluticasone Propionate EP Impurity F is an impurity of Fluticasone Propionate. Fluticasone Propionate is a synthetic glucocorticoid used in the treatment of asthma and other allergic disorders. Impurity F is a metabolite of Fluticasone Propionate and has been detected in human plasma at low levels (5% of total fluticasone propionate). The metabolism of Fluticasone Propionate to Impurity F has been studied in rat, mouse, dog and man. br>br> The following table summarizes the metabolic pathways that have been identified for this impurity: br>br> Metabolism studies indicate that Impurity F is mainly metabolized by CYP3A4 to form conjugates with glucuronic acid or sulfates. It may also be hydrolyzed to form 5α-flurostan-3β,17β-dFórmula:C25H29F3O5SPureza:Min. 95%Forma y color:PowderPeso molecular:498.56 g/molRitonavir Impurity G
CAS:Ritonavir is a protease inhibitor that prevents HIV from replicating. It binds to the active site of the protease enzyme and inhibits its activity, which prevents the conversion of viral proteins into their respective functional forms. Ritonavir impurity G is a metabolite that is not present in the final drug product. This impurity standard has been characterized by HPLC and NMR spectroscopy.Fórmula:C37H48N6O7S2Pureza:Min. 95%Peso molecular:752.9 g/mol
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