APIs para investigación e impurezas

<p>Mutagen X is an anticancer drug that works by inhibiting kinases, which are enzymes involved in cell cycle regulation and apoptosis. It has been shown to be effective against a variety of human cancer cells, including those from Chinese hamsters. Mutagen X is a potent inhibitor of protein kinases, which play a key role in the growth and proliferation of cancer cells. It has been found to have a high level of potency against tumor cells and can be used as a medicinal drug for cancer treatment. Mutagen X also acts as an inhibitor in urine and has been shown to be effective against various inhibitors.</p>

<p>Ergoline-8β-carboxylic acid methyl ester hydrochloride is a drug product that has been developed for research and development. It is an analytical standard, impurity standard, and HPLC standard. Ergoline-8β-carboxylic acid methyl ester hydrochloride is a metabolite of ergometrine, which is an ergot alkaloid with pharmacological properties similar to those of ergonovine. Ergoline-8β-carboxylic acid methyl ester hydrochloride is used as an impurity in the synthesis of ergometrine. The purity of this compound meets the requirements of pharmacopoeia standards for use as an analytical reference substance.</p>

<p>Please enquire for more information about 2′,4′′-Bis-O-(trimethylsilyl)-erythromycin 9-[O-(1-ethoxy-1-methylethyl)oxime] including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>α,α'-Bis[(2-methoxyphenoxy)methyl]-1,4-piperazinediethanol is an impurity in the drug ranolazine. It is a dimer of the active compound α,α'-bis[2-(methoxy)phenoxy]methyl-1,4-piperazine. This impurity has been shown to have antiarrhythmic properties.</p>

<p>Bisoprolol impurity G is a metabolite of bisoprolol. It is the standard for bisoprolol impurities and is used as an analytical reference material for the quality control of bisoprolol.</p>

<p>Foxy 5 trifluoroacetic acid is a nanofiber that can be used to create a cancer-fighting drug. It is made of polymers and has been shown to have the ability to absorb electromagnetic fields from all directions. Foxy 5 trifluoroacetic acid is packaged in a small, easy-to-handle container that releases the drug when the package is positioned against the tumor. This drug can be used for colon cancer and colorectal cancer because it targets only cells with efflux proteins, which are proteins that promote cancer cell metastasis. In addition, Foxy 5 trifluoroacetic acid has been shown to be effective against prostate and breast cancers by targeting specific receptors on these cells.</p>

<p>7 S-Cefdinir is an oral cephalosporin antibiotic that binds to penicillin-binding proteins in the bacterial cell wall by competitive inhibition. This binding prevents the formation of an antibiotic-inhibitor complex with transpeptidase and transpeptidase, which are enzymes involved in peptidoglycan synthesis. 7 S-Cefdinir also inhibits pentapeptide cross-linking, which is necessary for the formation of peptidoglycan chains. 7 S-Cefdinir has bactericidal activity against a wide range of bacteria and acts as an antibacterial agent. It is active against erythromycin-resistant strains of Streptococcus pneumoniae and Mycoplasma pneumoniae, but not against methicillin-resistant Staphylococcus aureus (MRSA).</p>

<p>Zuclopenthixol decanoate is an antipsychotic drug that is used to treat chronic schizophrenia. It has a well-tolerated side effect profile, and is effective in treating psychotic disorders. Studies on zuclopenthixol decanoate have shown that it has few drug interactions and low incidence of motor side effects. It is not associated with extrapyramidal symptoms or tardive dyskinesia. Zuclopenthixol decanoate has been shown to be effective in the treatment of psychotic disorders when used as monotherapy or in combination with other drugs, such as paliperidone. The most common side effects reported are nausea, constipation, headache, sleepiness and dizziness.</p>

<p>6-Acetoxymethyl-4-methoxy-5-methyl-3-pyridylmethanol o-toluate is a synthetic compound that is used as an analytical reference standard for the metabolism studies. It has been evaluated in a pharmacopoeia and has been found to be of high purity with no detectable impurities. This product can be used in drug development or research and development.</p>

<p>Please enquire for more information about 1-(2-Pyridinyl)cyclobutylamine including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about CDK9-IN-8 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

1,4-Di-2-furoylpiperazine is a synthetic compound that has been shown to have anti-inflammatory and analgesic properties. It was originally developed as a pharmaceutical drug candidate for the treatment of arthritis and other inflammatory disorders. 1,4-Di-2-furoylpiperazine is an impurity in the synthesis of the drug product diclofenac. The compound is also found as a metabolite in humans after oral administration of diclofenac. 1,4-Di-2-furoylpiperazine binds to protein and inhibits protein synthesis by preventing amino acid incorporation into proteins. It also has nicotinic effects on acetylcholine binding sites and can be used as an analytical standard for HPLC analysis of drugs containing this molecule.

2-Acetoxy-1,4-naphthoquinone is a potent inhibitor of kinases and has shown to have anticancer properties. It is an analog of the natural compound shikonin found in Chinese medicinal plants. This compound induces apoptosis in cancer cells and has been shown to inhibit the growth of tumor cells. 2-Acetoxy-1,4-naphthoquinone has been found in human urine and may play a role in the prevention of cancer. This compound is a promising candidate for the development of kinase inhibitors for use in cancer treatment.

<p>Sacubitril methyl ester is a drug product that belongs to the group of angiotensin receptor blockers. It is a prodrug that is metabolized in vivo to its active form, sacubitril. Sacubitril methyl ester has been shown to be effective in reducing morbidity and mortality in patients with chronic heart failure.</p>

N-Acetyl-L-cystine is a water soluble amino acid that has been approved for treatment of cystic fibrosis in adults and children older than six years. It is available as an aerosol, nebulized solution or oral capsule. N-Acetyl-L-cystine has been shown to have a protective effect against influenza virus (Virus A) infection by reducing the proinflammatory cytokines and reactive oxygen species in response to the virus. This drug also reduces the severity of symptoms associated with influenza virus infection. The pharmacokinetic properties of this drug are well understood, as it is stable in vivo, crosses the blood brain barrier, and does not bind to serum proteins.

<p>O-Acetyl silodosin is a synthetic, natural metabolite of silodosin. It is a nicotinic acid derivate that inhibits the activity of phosphodiesterase type 5 (PDE5) and has been used as a research and development standard for PDE5 inhibitors. O-Acetyl silodosin is an impurity in the commercial drug product, Silodosin®.</p>

<p>Ent-ramipril is a natural product that is a metabolite of ramipril. It can be synthesized from the quinone methide intermediate obtained by reaction of amine with ethyl acetoacetate. This synthetic route has been developed for the production of high purity, analytical grade ent-ramipril. The compound has not been found in natural sources and is not used as a drug product. Ent-ramipril is not an impurity standard, but it can be used as a research and development or HPLC standard.</p>

<p>3-Descyano febuxostat ethyl ester is a synthetic, natural, and API impurity. 3-Descyano febuxostat ethyl ester is used as an analytical standard in drug development. It is also used as a custom synthesis, impurity standard and analytical reference material.</p>

1-Stearoyl-2-arachidonoyl-sn-glycero-3-phosphoinositol (1SA2AP) is a glycerophospholipid that is the major phosphatidylinositol in platelets. 1SA2AP is hydrolyzed by phospholipase A2 into arachidonic acid and 1,2-diacylglycerol. The selectivity of 1SA2AP for ionization mass spectrometry has been demonstrated using ethanolamine and choline as standards. In this study, a kinetic method was used to determine the sensitivity and selectivity of electrospray ionization mass spectrometry for 1SA2AP. Analytical results were obtained from data collected from the analysis of two samples containing different concentrations of 1SA2AP.

<p>Zanapezil is a human and Chinese analog of mirtazapine that has been studied for its potential anticancer properties. It is a protein kinase inhibitor that targets multiple kinases involved in cancer cell growth and survival, leading to induction of apoptosis (programmed cell death) in cancer cells. Zanapezil has been shown to be effective against various types of tumors, including lung cancer, breast cancer, and prostate cancer. It can be detected in urine after administration, making it a potential biomarker for monitoring treatment efficacy. With its promising anticancer activity and specificity as a kinase inhibitor, Zanapezil may offer new hope for cancer patients.</p>

<p>9-Methylamino minocycline is a semi-synthetic antibiotic with excellent oral bioavailability. It can be used in the treatment of acne, inflammatory bowel disease, and rheumatoid arthritis. 9-Methylamino minocycline is an impurity that occurs during the synthesis of minocycline. It has been shown to inhibit protein synthesis by binding to the ribosome and preventing peptide bond formation. This impurity also inhibits RNA polymerase activity, which may account for its antimicrobial properties.</p>

<p>Please enquire for more information about Pregabalin inhouse impurity (RS-mme) including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>N-Isopropylnoradrenochrome is used as a fluorescent substrate for hydroxylamine. It has also been shown to be a useful catalyst for the synthesis of alkali metal hydrazides and to have hypotensive properties. N-Isopropylnoradrenochrome has been used in the synthesis of pharmaceutical preparations, such as migraine prophylaxis, and yields an hydrazone when irradiated with light.</p>

<p>4,4'-Dichlorobibenzyl is an impurity in the synthesis of bibenzyl. It is a metabolite of bibenzyl and has been detected in urine samples. 4,4'-Dichlorobibenzyl has been identified as a target for analytical methods because it is difficult to measure in biological samples due to its low concentration. It can be used as an impurity standard for HPLC analysis and has shown potential as a pharmacopoeia reference material.</p>

<p>16alfa-methyl-11beta,21-dihydroxy-6beta,9alfa-difluoropregnane-1,4-diene-3,20-dione-21-valerate is a synthetic drug product with the CAS number of 51622-42-5. The molecular weight is 471.82 g/mol and it has a purity of &gt; 98%. It is an analytical standard for the metabolite of 16alfa methyl 11beta,21 -dihydroxy 6beta,9alfa difluoropregnane 1,4 diene 3,20 dione 21 valerate. This compound also acts as a research and development standard for HPLC and can be used to study metabolism studies.</p>

<p>Dopamine (D2 and D3) receptor agonist; has anti-parkinsonian effects</p>

<p>N-Methyl amisulpride is a synthetic drug with antipsychotic properties. It is used in the treatment of schizophrenia and related psychotic disorders. N-Methyl amisulpride has been shown to be effective against the metabolites, such as naphthol and homovanillic acid, that are produced by dopamine and serotonin. This product can also be used as an impurity standard for the synthesis of other drugs or for HPLC analysis.</p>

<p>Remdesivir related compound 7 is a drug product that is being synthesized for use in research and development. The synthesis of this compound will be carried out with an analytical purity of greater than 98%. This custom synthesis is not a natural product and has been designed for use in pharmacopoeia. Remdesivir related compound 7 metabolizes to form metabolites that are impurities. It is an API impurity that can be used as a synthetic standard or impurity standard for HPLC testing.</p>

<p>Amino albendazole sulfone is an anthelmintic drug that is used to treat worm infestations in animals. It is the active metabolite of fenbendazole sulfone and has a terminal half-life of 12 hours in humans. Amino albendazole sulfone can be prepared by chromatographic methods, such as liquid chromatography or gas chromatography, and it can be analyzed with a fluorescence detector. This drug has been shown to have a concentration–time curve following administration to rats and results in an increase in the number of worms eliminated from the body.</p>

(1-(Cyanomethyl)cyclopropyl)methyl methanesulfonate is a potent inhibitor of kinases, which are enzymes that play a critical role in tumor growth and replication. This compound has been shown to inhibit the activity of several cancer cell lines, including those resistant to methotrexate, by inducing apoptosis. It is an analog of astaxanthin, a natural antioxidant found in Chinese urine. This compound has potential as a cancer therapeutic due to its ability to selectively target cancer cells while sparing normal human cells. Additionally, (1-(Cyanomethyl)cyclopropyl)methyl methanesulfonate may be used as a kinase inhibitor in research settings to further understand the mechanisms behind cancer growth and develop new inhibitors for potential therapies.

Fluticasone Impurity D is a sulfoxide that is found in the drug fluticasone. It is a conjugate of fatty acid and fatty alcohol, which are esters of irritants. Fluticasone Impurity D is an experimental model for inflammatory diseases. It can be used as a pharmaceutical dosage to enhance the effects of other drugs by increasing their absorption through the skin. The effects of this drug have been tested on tissues and experimental models, but not on humans.

<p>Di-destriazole anastrozole dimer impurity is a synthetic impurity that is created during the synthesis of anastrozole. It has been studied as a possible metabolite of the drug, but its role in metabolism is not well understood. Di-destriazole anastrozole dimer impurity is soluble in water and methanol and has a melting point of between 1°C to 2°C. The purity of this compound is typically at least 99% with a specific gravity of 1.043 g/mL.</p>

Please enquire for more information about 7-Hydroxy-furo[3,4-b]pyrazin-5-one including the price, delivery time and more detailed product information at the technical inquiry form on this page

<p>Tiagabine is an ester hydrochloride that is used to treat the symptoms of Parkinson's disease. Tiagabine inhibits GABA transaminase, which converts GABA into its active form, and thus prevents the breakdown of GABA in the brain. This drug also has inhibitory properties against HIV infection and has been shown to reduce neuronal death in vitro. Tiagabine has shown a positive response in clinical trials with human subjects with Parkinson's disease. Tiagabine can be taken orally or intravenously, but should not be taken with food or grapefruit juice due to increased bioavailability of the drug. This medication does not have any clinically significant pharmacokinetic interactions and does not affect hepatic function.</p>

Raltegravir is a drug that inhibits HIV-1 protease. It is an analytical standard for HPLC, and can be used in the development of drugs, including as an impurity standard. Raltegravir has shown promising results in clinical trials, but it is not available commercially. The chemical compound 2-des(5-methyl-1,3,4-oxadiazole-2-carboxamide) 2-(2-amino-2-oxoacetic acid) raltegravir has CAS No. 1064706-98-4 and is a natural product.

<p>Vigabatrin EP Impurity B is a research and development impurity standard that belongs to the class of drugs. It is an impurity in Vigabatrin, a drug product that has been developed for the treatment of epilepsy. Vigabatrin EP Impurity B is a metabolite of vigabatrin and can be found in the urine of patients who have taken this drug. This compound was not detected in other body fluids such as serum or plasma. The chemical name for this impurity is 2,3-dihydro-3-methyl-4-[(2S)-2-[[(1R)-1-[(2S,3R)-2-(dimethylamino)cyclohexyl]ethenyl]amino]-1-piperidinyl]butanoic acid methyl ester hydrochloride.</p>

<p>DC-5163 is a protein analog that has shown potent anticancer activity in preclinical studies. It inhibits the activity of kinases, which are enzymes involved in cancer cell growth and survival. DC-5163 has been shown to induce apoptosis, or programmed cell death, in various types of cancer cells, including those from human tumors and Chinese hamster ovary cells. This compound also acts as a toxin for cancer cells by interfering with their ability to divide and grow. In addition, DC-5163 has shown promising results as an inhibitor of tumor growth in animal models. Its potential as a therapeutic agent for cancer treatment is currently being investigated.</p>

<p>N-Desmethyl azithromycin B is a metabolite of the macrolide antibiotic azithromycin. It is an impurity in the drug product, and is present as an analytical standard for HPLC. N-Desmethyl azithromycin B can be found in the urine of patients taking azithromycin, but at much lower concentrations than the parent drug. This impurity is not toxicologically relevant, but may interfere with some analytical methods.</p>

<p>1-[2-(3-Chloro-2-hydroxypropoxy)phenyl]-3-phenyl-1-propanone is a synthetic drug product. It is an impurity standard for HPLC, and drug development and research. This compound is also used as an analytical reference. The CAS number for this chemical is 165279-79-8.</p>

<p>17-o-(Acetyl-d3)-6-methylprednisolone is a drug product that belongs to the group of corticosteroids. It is used for the treatment of inflammatory conditions and autoimmune diseases. This API is used as an impurity standard in analytical methods such as HPLC, and it can be synthesized from natural sources or synthetically. 17-o-(Acetyl-d3)-6-methylprednisolone can also be used in R&amp;D for the development of drugs targeting niche markets, such as those with high purity requirements.</p>

Prizidilol is a medicinal inhibitor that has shown promising results as an anticancer agent. It works by inhibiting protein kinases, which are enzymes involved in cell cycle regulation and apoptosis. Prizidilol has been found to be effective against cancer cells in both Chinese hamster and human urine tumor models. This inhibitor has also been shown to have potential as an analog for other inhibitors used in cancer research. Its ability to induce apoptosis in cancer cells makes it a promising candidate for future cancer therapies.

<p>Amoxicillin EP Impurity K is a synthetic impurity found in amoxicillin. Amoxicillin is an antibiotic that inhibits the growth of bacteria by binding to the 50S ribosomal subunit. Amoxicillin EP Impurity K is a metabolite of amoxicillin, which has been shown to inhibit protein synthesis and cell division. This impurity can be used as a reference material for analytical purposes or as a standard in drug development.</p>

<p>Please enquire for more information about N-Acetyl o-benzyl 5’-epi lamivudine including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Dispersants are substances that are used to break up and disperse particles in a liquid. The dispersant 11-[3-(dimethylamino)propyl]-6,11-dihydrodibenz[b,e]oxepin-11-ol is an active substance that is used in the production of granules, tablets or other solidified forms of medicaments. It is a substance that has a physiologically active effect on humans and animals. This product can be applied as droplets or particles.</p>

<p>(2S,3R)-2-(2,4-Difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2,3-butanediol is a synthetic drug product that has been found as an impurity in other drugs. It has a natural origin and can be synthesized by chemical methods. This compound is used in chemical analysis to determine the purity of the drug product. This compound is also used in research and development to develop drugs for niche markets. (2S,3R)-2-(2,4-Difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2,3-butanediol has high purity and meets pharmacopoeia standards.</p>

<p>Please enquire for more information about 4-[(Dimethylamino)iminomethyl]benzoic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Risperidone E-oxime impurity is a drug product that has been studied for its metabolism in humans, animals and plants. It is an analytical standard that is used as an impurity in the synthesis of risperidone. Risperidone E-oxime impurity is also a synthetic compound with CAS No. 691007-09-7. It can be used as a pharmacopoeia high purity HPLC standard and as a research and development synthetic compound.</p>

<p>Please enquire for more information about Clarithromycin-N-methyl-d3 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about (2S)-2-Amino-3-methoxy-N-(phenylmethyl)propanamide including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Ciprofibrate-o-β-glucuronide is the major metabolite of ciprofibrate in humans. It can be detected in urine by a variety of analytical methods, including magnetic resonance spectroscopy, voltammetry, and microscopy. Ciprofibrate-o-β-glucuronide is an enantiomer of ciprofibrate and has been shown to have an enzymatic hydrolysis rate of 0.07% per hour. This hydrolysis process is catalyzed by cytochrome P450 enzymes. Ciprofibrate-o-β-glucuronide is also found in pharmaceutical formulations and excreted from the body with a half life of 4 hours.</p>

<p>Talaromycesone A is a natural product derived from the fungus Talaromyces erythraeus. It is a metabolite of the antibiotic talaromycin and has been identified as an impurity in the drug product talaromycin sulfate. Talaromycesone A is a metabolite of the antibiotic talaromycin, which is produced by Talaromyces erythraeus, and has been identified as an impurity in the drug product, talaromycin sulfate. The chemical name for this compound is 3-methyl-2-oxo-2H-chromene-6-carboxylic acid (1S,4R)-4-[(3S)-3,4-dimethylphenyl]-cyclohexyl ester.<br>Talaromycesone A was originally isolated from the fungus Talaromyces erythraeus and purified to be used as a reference standard for HPLC analysis</p>

<p>2,2',3,4,6,6'-Hexachlorobiphenyl is an analog of polychlorinated biphenyls (PCBs), which are toxic pollutants that have been widely used in industrial applications. This compound has been shown to inhibit the growth of cancer cells by targeting specific proteins involved in cell cycle regulation and apoptosis. It has demonstrated potent anticancer activity against various human tumor cell lines, including breast and prostate cancer cells. 2,2',3,4,6,6'-Hexachlorobiphenyl inhibits the activity of protein kinases that are essential for cancer cell survival and proliferation. In addition to its medicinal properties as an anticancer agent, it can also be detected in urine and serves as a biomarker for PCB exposure.</p>

<p>(aR)-a-Methyl-N-[3-[4-(trifluoromethyl)phenyl]propyl]-1-naphthalenemethanamine is a synthetic drug product that is used in research and development. It has been shown to have an analytical purity of 99.8%.</p>

<p>(-)-Nefopam is a medicinal compound that acts as an inhibitor of kinases, which are enzymes involved in many cellular processes. It has been shown to inhibit the growth of cancer cells by inducing apoptosis, or programmed cell death. In Chinese hamster ovary cells, (-)-Nefopam has been found to inhibit the uptake of xylose into the cell, suggesting that it may have an effect on carbohydrate metabolism. This compound has also been shown to interfere with the cell cycle and protein synthesis in human cancer cells. Overall, (-)-Nefopam shows promise as a potential therapeutic agent for cancer treatment.</p>

<p>Furegrelate is an analytical reference standard for the hydroxylation of 4-(4-amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl[(5S)-tetrahydro-5-methyl-2-furanyl]-methanone. Furegrelate is a synthetic drug product that has been used in pharmacological and toxicological research. It is a metabolite of the drug Furosemide, which is used to treat heart failure and high blood pressure. Furegrelate has also been found as an impurity in the API (active pharmaceutical ingredient) of other drugs such as Carvedilol and Metoprolol.</p>

<p>11,12-EET is an analog of the human protein that has been found to have potential medicinal benefits in the treatment of cancer. It acts as an inhibitor of kinases, which are enzymes that play a key role in the regulation of cell growth and division. 11,12-EET has been shown to induce apoptosis, or programmed cell death, in cancer cells, making it a promising anticancer agent. This compound has also been detected in urine samples from Chinese patients with various types of tumors. Ongoing research is exploring the potential use of 11,12-EET as a kinase inhibitor for the treatment of cancer.</p>

<p>The objective of the research was to identify and validate a validated analytical method for N-desmethyl-N-benzyl sildenafil (DMB) in dietary supplements. The validation parameters evaluated were linearity, precision, accuracy, and limit of detection. The population parameter was the mean DMB content in dietary supplements. The calibration curve for DMB was linear over the range of 0.2–50 μg/g with an R2=0.9994 and a limit of detection of 0.02 μg/g. Accuracy values were within ±5%. Systematic errors were determined at two levels: 10% and 5%. Limit of quantitation was 1 μg/g, which is equivalent to a daily intake of 3 mg.</p>

<p>Enrofloxacin impurity E is a product of the synthesis of enrofloxacin, with high purity and analytical standards. It is synthesized from natural products, and it can be used as an impurity standard for HPLC analysis. Enrofloxacin impurity E also has pharmacopoeia and CAS number 1369495-59-9. This substance is used in drug development and research to study metabolism.</p>

<p>Flumethasone Impurity 10 is a synthetic drug product. It is for research and development purposes only and not for use in humans. Flumethasone Impurity 10 is metabolized through a number of metabolic transformations, including hydrolysis by esterases or glucuronidases, oxidation by cytochrome P450 enzymes, reduction by glutathione reductase, or conjugation with glucuronic acid. Flumethasone Impurity 10 can be used as an impurity standard for the determination of flumethasone in biological fluids.</p>

<p>Nicergoline EP Impurity B is a metabolite of nicergoline, a drug product. It has been synthesized for use as an impurity standard for analytical and pharmacopoeia purposes. Nicergoline EP Impurity B is not found in nature and has been shown to be metabolically stable in vitro. It can be used as a reference substance for the determination of nicergoline concentrations in human plasma samples.</p>

<p>Please enquire for more information about 3,14-Dihydroxy 14β-estra-1,3,5(10)-trien-17-one including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Chlorthalidone Dimer is a high purity, analytical standard for chlorthalidone. It is used as an impurity in the manufacture of chlorthalidone and may be used as a reference standard or an HPLC standard.</p>

<p>Bu 224 hydrochloride is an exogenous ligand that binds to the imidazoline I1 receptor. It is a potent and selective agonist for this receptor, which has been shown to be located in cardiac tissue. Bu 224 hydrochloride has been shown to increase the release of noradrenaline from cardiac cells, resulting in cardiostimulant effects. The binding of Bu 224 hydrochloride to the I1 receptor also increases blood pressure, heart rate, and myocardial contractility. The effect on blood pressure is dose-dependent: low doses result in a mild increase in blood pressure, whereas higher doses can lead to severe hypertension.</p>

<p>1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofurancarboxaldehyde oxime is an impurity in the drug product of 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofuran. It is a metabolite that is formed during the metabolism of 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofuran by cytochrome P450 enzymes. The CAS number for this compound is 227954–88–3. This chemical is not found in nature and can be synthesized in the laboratory.</p>

Bimatoprost acid methyl ester is a medicament, which is a prostaglandin that is used for the treatment of glaucoma. It has a number of analogues, including bimatoprost and latanoprost. Bimatoprost acid methyl ester is used in crystalline form and as an intermediate in the synthesis of other prostaglandins. This product can be found in polymorphic form.

<p>Levovirin is an antiviral agent that belongs to the class of ribonucleotide reductase inhibitors. It is a potent inhibitor of hepatitis C virus replication and has been shown to be active against HIV in vitro. Levovirin acts as a competitive inhibitor of the NS3 protease, which is responsible for processing viral proteins. This inhibition prevents the production of new virus particles and the spread of infection. Levovirin also has immunomodulatory effects, which may provide therapeutic benefits in autoimmune diseases such as rheumatoid arthritis or Crohn's disease.</p>

<p>PBB 154 is a medicinal compound that has shown promising results in the treatment of cancer. This analog of a kinase inhibitor has been found to inhibit the activity of kinases, which are enzymes that regulate cell cycle progression and play a critical role in tumor growth. PBB 154 has been shown to induce apoptosis, or programmed cell death, in cancer cells. This compound has also been found to be effective against various types of cancer, including breast, prostate, and lung cancer. PBB 154 is an anticancer agent that works by inhibiting the activity of proteins involved in cell division and promoting apoptosis in cancer cells. It can be detected in urine and has potential for use as a diagnostic tool for detecting early stages of cancer.</p>

<p>Fijimycin B is a medicinal compound that acts as an inhibitor of kinases, which are proteins that play a crucial role in cancer cell growth and proliferation. This analog of the natural product fijimycin has been shown to induce apoptosis (cell death) in tumor cells and exhibits potent anticancer activity. Fijimycin B has been isolated from human urine and Chinese medicinal herbs, and it has been found to be a highly selective inhibitor of certain kinases. This compound shows promise as a potential therapeutic agent for the treatment of various types of cancer. Its ability to target specific kinases makes it an attractive option for developing targeted inhibitors that can selectively kill cancer cells while sparing healthy cells.</p>

<p>2,6-Diisopropyl-1,4-benzoquinone is a diphenol that reacts with a variety of organic compounds in the presence of heat. It has been used as a mesoporous material to adsorb hydrogen gas and carbon dioxide in the water treatment process. 2,6-Diisopropyl-1,4-benzoquinone is also able to react with oxygen to form an n-oxide. This compound is most often used for the manufacture of phenolic antioxidants such as dibenzoyl peroxide and pentafluorobenzoic acid. The active site on this molecule is thought to be at the double bond between carbons 6 and 7. Impurities may include anisidine and other aromatic amines that can cause reactions with hydrogen peroxide when exposed to light or certain wavelengths of radiation.</p>

<p>Bortezomib impurity 76 is an analytical reference material that is used in the development and production of pharmaceuticals. It is a high purity, HPLC standard for use as an impurity in the manufacture of bortezomib API. This material is a metabolite of bortezomib and it has been shown to be pharmacologically active. Bortezomib impurity 76 can also be used as an HPLC standard for drug product analysis.</p>

<p>Frovatriptan is a drug used to treat migraine attacks. It belongs to the triptan class of drugs and is used for the acute treatment of migraine with or without aura in adults. Frovatriptan is an agonist at serotonin 5-HT1B and 5-HT1D receptors, which are thought to be involved in headache pain. It has been shown that frovatriptan can provide relief from migraine pain within 2 hours of administration and that the drug can last up to 24 hours. This drug is contraindicated for use in patients who have hepatic impairment or are taking nonsteroidal anti-inflammatory drugs (NSAIDs). The efficacy of frovatriptan has also been shown in clinical trials, where it was found that over 50% of patients had a 50% reduction in headache severity after 2 hours with a median time to onset being 15 minutes.</p>

<p>Regorafenib metabolite M2 oxide (M2O) is a cancer drug that is an inhibitor of multikinase. It was developed as a prodrug for regorafenib, which is used to treat patients with metastatic colorectal cancer and has been shown to be effective against other cancers, such as lung and pancreatic cancer. M2O inhibits the efflux of drugs from cells by binding to the transporter protein P-glycoprotein. This prevents the accumulation of toxic concentrations of regorafenib in cells, which are responsible for its side effects, such as diarrhea and liver damage. The uptake of M2O by cells is also inhibited by light and acidic conditions. Oral administration of M2O leads to increased exposure to regorafenib in the body because it is not metabolized by CYP3A4 enzymes.</p>

<p>Aripiprazole impurity is a synthetic impurity that is used as an impurity standard for the pharmaceutical industry. It is used to test the purity of drug products and to assess the quality of raw materials. Aripiprazole impurity is also used in metabolite profiling studies, analytical testing, and pharmacopoeia research and development. This compound has a CAS number of 1797983-65-3.</p>

<p>4’-(7-Dechloroquinolinyl) piperaquine is an inhibitor of tumor kinases and has shown potent anticancer activity against various cancer cells. This compound is a derivative of piperaquine, which is commonly used as an antimalarial drug. 4’-(7-Dechloroquinolinyl) piperaquine has been found to induce apoptosis in human cancer cells by inhibiting the activity of protein kinases that are essential for cell growth and division. It has also been shown to have synergistic effects with capsaicin, a natural compound found in chili peppers, in inhibiting the growth of cancer cells. Additionally, this analog has been detected in human urine after administration, indicating its potential use as a therapeutic agent for cancer treatment.</p>

Nicardipine is a drug product that has been shown to have pharmacological effects. It is an anti-anginal agent and vasodilator. Nicardipine has been shown to be effective in the treatment of angina pectoris and coronary artery disease, as well as hypertension. Nicardipine is an analytical standard for the impurity standards of nicardipine o-desmethyl-o-methyl(phenylmethyl)amino]ethyl) ester hydrochloride, which are used in the synthesis of nicardipine. Nicardipine also acts as a research and development drug for the treatment of heart diseases, hypertension, and other conditions. High purity nicardipine is available on request from our custom synthesis division.

<p>Brobactam is a potent inhibitor of beta-lactamase enzymes and is often used in combination with other antibiotics to enhance their efficacy. It has been shown to be effective against gram-negative bacteria, including those that are resistant to other antibiotics. Brobactam has also been investigated for its potential use in cancer treatment. Studies have shown that brobactam can induce apoptosis in cancer cells by inhibiting kinase activity, which is essential for cell survival and proliferation. In addition, brobactam analogs have been developed that show promising anticancer activity against human cancer cell lines and Chinese hamster ovary cells. Overall, brobactam has the potential to be a valuable tool in the fight against both bacterial infections and cancer.</p>

<p>Deterenol-d7 hydrochloride is a drug product that is an analytical standard. Deterenol-d7 hydrochloride is used in metabolism studies and has been shown to be natural, with the CAS number of 1246817-36-6. Deterenol-d7 hydrochloride also has impurities that are identified as synthetic, which may have an impact on its potency. Deterenol-d7 hydrochloride can be used for Custom synthesis and Drug development, as well as Research and Development. The drug product is a niche compound, with a high purity level of 99%. Deterenol-d7 hydrochloride is a HPLC standard and complies with pharmacopoeia guidelines.</p>

<p>Losartan is a drug that is used to treat high blood pressure and congestive heart failure. It is an angiotensin II receptor antagonist that blocks the binding of angiotensin II to its receptor, preventing the activation of protein kinase A and the release of aldosterone. Losartan is also known as losartan-related compound E (LZE). LZE has been shown to have a papain-like protease activity with a light chain. This activity may be responsible for its anti-diabetic effects. LZE has been shown to inhibit hyperglycemia in mice by reducing serum glucose levels and increasing insulin sensitivity. In addition, LZE has been shown to reduce cardiac death in rats by activating nuclear factor erythroid 2-related factor 2 (Nrf2), which induces expression of antioxidant enzymes such as heme oxygenase 1 and superoxide dismutase 1 (SOD1).</p>

<p>Racecadotril Impurity G is an analytical impurity found in the drug Racecadotril. It has been observed as a minor component in HPLC standards and can be synthesized from natural or synthetic sources. Racecadotril Impurity G is not found in the pharmacopoeia and does not have a CAS number.</p>

<p>3-(Cyanomethyl)-N-methyl-1H-indole-5-methanesulfonamide is an analytical standard, used for HPLC analysis of impurities. It is also used as a reference in certain pharmacopoeia standards, such as the USP and EP. 3-(Cyanomethyl)-N-methyl-1H-indole-5-methanesulfonamide has a purity of 99% and can be found in the drug product Impurity Standard.</p>

Please enquire for more information about N-tert-Butyloxycarbonyl hydroxy brimonidine including the price, delivery time and more detailed product information at the technical inquiry form on this page

<p>Please enquire for more information about Carvedilol tetra(alkylpyrocatechol) impurity including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>AAK1-IN-1 is a potent inhibitor of the AAK1 kinase, which plays a crucial role in regulating cell cycle progression and apoptosis. This inhibitor has shown promising results in pre-clinical studies for the treatment of cancer, particularly leukemia. AAK1-IN-1 has been found to effectively inhibit the growth of human cancer cell lines and Chinese medicinal tumor cells by blocking the activity of AAK1 kinase. This protein is involved in several cellular processes, including signal transduction pathways and protein trafficking, making it an attractive target for cancer therapy. The use of AAK1-IN-1 as a novel kinase inhibitor may offer new opportunities for developing effective treatments against various types of cancer.</p>

<p>Rivaroxaban N-Hydrolyse N-5-Chlorothiophene-2-carbaldehyde is a drug product that is used as an analytical standard to study the metabolism of rivaroxaban. It is produced by custom synthesis and has been confirmed to be a high purity, pharmacopoeia grade material. This API impurity has CAS No. 1151893-81-0 and is classified as a natural material.</p>

<p>1-(3'-Pyridylmethyl)-3-(4'-nitrophenyl)urea is a medicinal compound that has been used in Chinese traditional medicine for its tumor-fighting properties. It acts as a potent inhibitor of protein kinases, which are enzymes involved in cell signaling and proliferation. This analog has been shown to induce apoptosis, or programmed cell death, in cancer cells by inhibiting the activity of specific kinases. The compound has also demonstrated anticancer activity in human cancer cell lines and may have potential as a therapeutic agent for the treatment of various types of cancer. Additionally, 1-(3'-Pyridylmethyl)-3-(4'-nitrophenyl)urea can be detected in urine and may serve as a biomarker for kinase inhibitor activity.</p>

<p>Gatifloxacin is a fluoroquinolone antibiotic that inhibits the DNA gyrase and topoisomerase IV, which are enzymes that maintain the integrity of bacterial DNA. It binds to bacterial 16S ribosomal RNA and inhibits protein synthesis, leading to cell death by inhibiting the production of proteins vital for cell division. Gatifloxacin has been shown to be effective against methicillin-resistant Staphylococcus aureus (MRSA) and Clostridium perfringens, although is not active against acid-fast bacteria such as Mycobacterium tuberculosis or Mycobacterium avium complex. Gatifloxacin has shown anti-inflammatory properties, which may be due to its inhibition of prostaglandin synthesis.<br>4'-[(4'Methyl-2'-propyl[2,6'-bi-1H-benzimidazol]-1'-yl)methyl][</p>

<p>Taiwanin C is an analog of dabigatran, a potent inhibitor of kinases that has been shown to have anticancer properties. It has been found to inhibit the growth of tumor cells in vitro and in vivo, inducing apoptosis and reducing protein expression. Taiwanin C has also shown promising results in inhibiting the activity of various kinases involved in cancer cell proliferation and survival. This compound is derived from Chinese herbal medicine and can be detected in urine after administration. Its potential as an anticancer agent makes it a promising area for further research into new cancer therapies.</p>

<p>3,4-Dihydro-4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylic acid ethyl ester 1,1-dioxide is a synthetic sulfoxide that is used as an antiinflammatory drug. It is a stable compound that can be used in the production of dimethyl sulfoxide and piroxicam. The purity of this compound is greater than 99.5%.</p>