APIs para investigación e impurezas

<p>Alverine EP Impurity D is a synthetic impurity that is the result of the synthesis of Alverine EP. It is a metabolite that can be found in blood plasma and urine. This substance has been shown to have pharmacological activity, but its exact function is unknown. It is not present in natural sources and it does not have pharmacopoeia listing. Alverine EP Impurity D has been detected by HPLC analysis.END&gt;</p>

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<p>N-Demethyl pazopanib is a synthetic drug that has been researched and developed for the treatment of cancer. It is an impurity standard, custom synthesis, and drug product. Synthetic N-demethyl pazopanib is used in clinical trials as a research and development tool to explore the metabolism of this drug and its metabolites. High purity N-demethyl pazopanib is used as a pharmacopoeia reference material for HPLC analysis in pharmacological studies. The metabolite of N-demethyl pazopanib has been found to be carcinogenic in animal studies. Metabolism studies have shown that N-demethyl pazopanib undergoes extensive hydroxylation and glucuronidation, which are detoxification pathways for xenobiotics in mammals.</p>

<p>Moncrotophos is an anticancer agent that has been shown to inhibit the activity of kinases, enzymes that play a crucial role in cell growth and proliferation. This inhibitor has been found to induce apoptosis, or programmed cell death, in cancer cells. Moncrotophos is a synthetic analog of ghrelin, a hormone that regulates appetite and energy balance in humans. It has been shown to have potent inhibitory effects on tumor growth in animal models and human cancer cell lines. In addition to its anticancer properties, Moncrotophos has also been investigated as a potential treatment for other diseases such as diabetes and obesity due to its ability to regulate glucose metabolism. However, caution should be exercised when using this product as it can be toxic if not used properly.</p>

<p>Methyl 4-methyl-3-[2-(propylamino)acetamido]thiophene-2-carboxylate is an impurity that can be found in the drug product. It is a metabolite of clozapine, which is used to treat schizophrenia and other psychiatric disorders. This impurity can be detected by HPLC or LC/MS analysis and quantified using a calibration curve generated from standards. Methyl 4-methyl-3-[2-(propylamino)acetamido]thiophene-2-carboxylate may also be found in the urine as an indicator of clozapine use.</p>

<p>Warfarin is a clinically used drug that is an anticoagulant and has been shown to have anticancer activity. Warfarin has been shown to inhibit the synthesis of unsaturated ketones by carbonyl reduction and asymmetric synthesis. It also inhibits the growth of cancer cells in animals and human liver cells. Warfarin reduces the production of coagulation factors II, VII, IX, and X by inhibiting protein synthesis in the liver. The anticoagulant effect of warfarin is due to inhibition of the synthesis of vitamin K-dependent clotting factors II, VII, IX, and X. Warfarin also binds to a cytosolic protein called matrix metalloproteinase-9 (MMP-9) which inhibits its proteolytic activity.</p>

<p>1-(3,5-Dihydroxyphenyl)-2-[(1,1-dimethylethyl)amino]-ethanone hydrochloride (HDPAE) is a drug product for the treatment of metabolic disorders. HDPAE is synthesized in high purity and has been studied for its metabolism and therapeutic effect. The CAS number for this compound is 1246815-70-2. This compound can be found in natural sources such as plants and animals, but it is also synthetically produced. HDPAE has not been evaluated by the FDA or any other regulatory agency and may not be available to consumers.</p>

<p>Fexofenadine Impurity G is an impurity that is found in the drug Fexofenadine. This impurity can be identified and quantified using HPLC with a UV detector at 254 nm. Fexofenadine Impurity G has been classified as a natural metabolite of Fexofenadine. It is also considered to be a synthetic impurity because it can be synthesized in the laboratory.</p>

<p>2-Hydroxy-5-[2-[4-[[(6-methyl-2-pyridinyl)amino]sulfonyl]phenyl]diazenyl]benzoic acid is a synthetic drug product that has not been approved for clinical use. 2-Hydroxy-5-[2-[4-[[(6-methyl-2-pyridinyl)amino]sulfonyl]phenyl]- diazenyl]benzoic acid is a metabolite of the drug product, 3-(2,4,6,-trimethoxybenzoyl)-1-(pyridinium methyl) piperidine. This metabolite was isolated and characterized using high performance liquid chromatography (HPLC), gas chromatography (GC), and nuclear magnetic resonance spectroscopy.</p>

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<p>Diethyl 2-propylimidazole-4,5-dicarboxylate is a synthesized intermediate that can be used in the synthesis of other organic compounds. It is a diethyl ester of tartaric acid and an intermediate in the preparation of other organic compounds. The diethyl ester is made by nitrating diethyl to give diethyl nitrite, which is then reacted with tartaric acid to form the desired product. Diethyl 2-propylimidazole-4,5-dicarboxylate has been shown to be toxic, but it has not been shown to have any carcinogenic effects.</p>

<p>o-Desmethyl venlafaxine N-dimer is a metabolite of venlafaxine that has been identified in human plasma. It is a white to off-white crystalline powder with a melting point of about 175°C. The purity of the product is more than 98%. It is soluble in methanol and ethanol, but insoluble in water. The o-desmethyl venlafaxine N-dimer was developed as an analytical reference standard for use in HPLC analysis of venlafaxine and its metabolites and impurities.</p>

<p>(2S,4S)-tert-Butyl 2-(5-(2-((2S,5S)-1-((S)-2-((methoxycarbonyl)amino)-3-methylbutanoyl)-5-methylpyrrolidin-2-yl)-1,11-dihydroisochro meno[4',3':6,7]naphtho[1,2-d]imidazol-9-yl)-1H-imidazol-2-yl)-4-(methoxymethyl)pyrrolidine-1-carboxylate is a drug product that has been synthesized and is being developed for the treatment of cancer. (2S,4S)-tert–Butyl 2-(5-(2-[(2R,5R)-1-[(R) -2-[(methoxycarbonyl)amino]-</p>

<p>MKK7-COV-9 is a potent inhibitor of kinases that plays a critical role in apoptosis, also known as programmed cell death. It has been extensively studied in Chinese and human tumor cells and has been shown to be an effective anticancer agent. MKK7-COV-9 is an analog of the cyclin-dependent kinase (CDK) inhibitors and has been found to inhibit the growth of cancer cells by blocking the activity of CDKs. This protein kinase inhibitor has also been found in urine samples from cancer patients, suggesting its potential as a biomarker for cancer diagnosis and treatment. The inhibitory effect of MKK7-COV-9 on tumor cell proliferation makes it a promising candidate for developing novel anticancer drugs.</p>

<p>2'-Deoxy-5,6-didehydro-2',2'-difluoro-6-hydroxyuridine is an analytical standard that is used in research and development of drugs. This compound has been designated as an impurity in a drug product. It has also been used as a reference standard for HPLC analysis. 2'-Deoxy-5,6-didehydro-2',2'-difluoro-6-hydroxyuridine is a metabolite of the drug product. This compound is not found in nature and has been synthesized artificially.</p>

<p>Avocadyne is a bioactive compound, which is sourced from avocados, specifically from the lipids extracted from the fruit. Its mode of action involves interacting with cellular pathways that are relevant to inflammation and metabolic regulation, showcasing effects that may influence various biochemical processes.Avocadyne has been primarily studied for its potential roles in therapeutic applications due to its anti-inflammatory and antioxidant properties. Research suggests that this compound may modulate signaling pathways related to lipid metabolism and oxidative stress, thus offering potential benefits in the management of conditions such as metabolic disorders and chronic inflammation. Additionally, its ability to interact with these pathways positions Avocadyne as a compound of interest for further investigation in the context of neurodegenerative diseases and certain cancers. Scientifically, the exploration of Avocadyne's effects on cellular models aims to elucidate its mechanism of action and optimize its potential therapeutic applications. This necessitates a thorough understanding of its biochemical interactions and the possible modulation of various molecular targets within diseased states.</p>

<p>3-Hydroxy darifenacin is a synthetic drug that is a prodrug of darifenacin. It has a niche application in the treatment of overactive bladder. This compound has been shown to be metabolized by CYP3A4 and CYP2D6. 3-Hydroxy darifenacin is an impurity standard for the HPLC assay of darifenacin and its metabolites.</p>

<p>Didemethyl rizatriptan hydrochloride is a potent anticancer agent that belongs to the indirubin analog family. It acts as a selective inhibitor of various kinases, including cyclin-dependent kinase (CDK), glycogen synthase kinase-3β (GSK-3β), and casein kinase 1 (CK1). This drug has been shown to induce apoptosis in various human cancer cell lines, including breast, prostate, and colon cancers. Didemethyl rizatriptan hydrochloride has also demonstrated significant tumor growth inhibition in animal models of cancer. Moreover, this drug can be detected in urine samples of Chinese patients with cancer who have received treatment with this inhibitor. Overall, didemethyl rizatriptan hydrochloride shows great promise as an effective protein kinase inhibitor for the treatment of cancer.</p>

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<p>Atorvastatin is a potent inhibitor of the enzyme HMG-CoA reductase, which is responsible for the conversion of HMG-CoA to mevalonate. This inhibition reduces the production of cholesterol and other lipids in the liver. Metabolism studies have shown that atorvastatin undergoes extensive presystemic metabolism by cytochrome P450 enzymes, primarily CYP3A4 and CYP2C9. The drug is converted to inactive metabolites that are eliminated primarily through renal excretion. Atorvastatin has not been found to inhibit any of the following: cytochrome P450 1A1/2, 2C8/9, 2D6, 2E1, 3A4/5 or glucuronidases.</p>

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<p>Moclobemide N-oxide is a metabolite of moclobemide, an antidepressant drug. It is a white to off-white crystalline powder with a molecular formula of C14H14N2O4 and a molecular weight of 237.3. Moclobemide N-oxide is used in the treatment of depression, but it has not been approved for clinical use in the United States. Moclobemide N-oxide is extensively metabolized by cytochrome P450 enzymes, which may lead to variations in its activity among patients.</p>

<p>Flumethasone Impurity 10 is a synthetic drug product. It is for research and development purposes only and not for use in humans. Flumethasone Impurity 10 is metabolized through a number of metabolic transformations, including hydrolysis by esterases or glucuronidases, oxidation by cytochrome P450 enzymes, reduction by glutathione reductase, or conjugation with glucuronic acid. Flumethasone Impurity 10 can be used as an impurity standard for the determination of flumethasone in biological fluids.</p>

<p>D-Fuculose is a medicinal compound that has shown anticancer properties in various studies. It is a kinase inhibitor that targets specific kinases involved in cancer cell growth and survival. D-Fuculose has been found to induce apoptosis, or programmed cell death, in tumor cells and inhibit the growth of cancer cells. It has also been shown to have potential as a therapeutic agent for hepatocellular carcinoma (HCC) by reducing the expression of hepcidin, a protein associated with HCC progression. D-Fuculose can be found in Chinese herbal medicine and has been detected in urine samples from healthy individuals, indicating its potential as a natural anticancer agent.</p>

<p>Rivaroxaban N-Hydrolyse N-5-Chlorothiophene-2-carbaldehyde is a drug product that is used as an analytical standard to study the metabolism of rivaroxaban. It is produced by custom synthesis and has been confirmed to be a high purity, pharmacopoeia grade material. This API impurity has CAS No. 1151893-81-0 and is classified as a natural material.</p>

<p>KSI-3716 is a potent inhibitor of kinases, which are enzymes that play a critical role in cancer cell growth and survival. This inhibitor has been shown to be effective against Chinese and human kinases, making it a promising candidate for the treatment of various types of cancer. KSI-3716 is an analog of oseltamivir, a drug used to treat influenza. It has been found to induce apoptosis in tumor cells by inhibiting the activity of protein kinases. KSI-3716 also shows anticancer activity in vivo, as demonstrated by its ability to inhibit tumor growth in mice models. This inhibitor may have potential therapeutic applications for the treatment of cancer and other diseases related to kinase dysregulation.</p>

<p>All-trans-retinal dimer trifluoroacetic acid salt is an analog of methotrexate, which is commonly used as an anticancer drug. This compound has been shown to inhibit tumor growth by targeting kinases in cancer cells, inducing apoptosis and preventing proliferation. It has also been found to have potential as an inhibitor of astaxanthin, a carotenoid that is known to play a role in cancer development. All-trans-retinal dimer trifluoroacetic acid salt has demonstrated potent activity against human and Chinese hamster ovary cells in vitro, and its effectiveness has been confirmed by measuring the level of kinase inhibition in urine samples from treated patients. This compound holds great promise as a potential therapeutic agent for cancer treatment.</p>

<p>Ropivacaine N-Oxide is a synthetic drug used to relieve pain during surgery. It is metabolized by the liver, with metabolites excreted in the urine. Ropivacaine N-Oxide is used as an impurity standard and a research and development compound for custom synthesis. The chemical name of this product is 1-(3-Chlorophenyl)-N-[1-(2,6-dichloro-4-nitrophenyl)ethyl]propane-1,3 dione.</p>

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<p>Tirofiban impurity 8 is an analytical standard for HPLC. It is a research-grade, high purity, impurity standard for the drug product. Tirofiban impurity 8 is a metabolite of tirofiban that has been shown to be pharmacologically active in animal models and in vitro. Tirofiban impurity 8 has a natural or synthetic origin and its CAS number is 2250244-25-6.</p>

<p>Meloxicam is a nonsteroidal anti-inflammatory drug (NSAID) that is used for the relief of inflammation and pain in osteoarthritis and rheumatoid arthritis. It is a stable, water-soluble prodrug of methylated meloxicam. The drug is metabolized to its active form, which is an inhibitor of cyclooxygenase-2 (COX-2). Meloxicam has been shown to be effective against COX-1, but not COX-2. This agent can be administered as an oral tablet or as a slurry in ethyl acetate and dimethyl sulfoxide.</p>

<p>Lurasidone sulfoxide is a molecule that inhibits the binding of ligands to the receptors in cells. It has been shown to be synergistic with other molecule inhibitors, such as virus and organosulfur compounds. Lurasidone sulfoxide also interacts with drug molecules and can be used to shift the paradigm of treatment for certain diseases. Lurasidone sulfoxide is cocrystallized with other molecules that are used for treatment or prevention of certain diseases, including HIV, hepatitis C, and cancer.</p>

<p>Methyl 5,6-dimethyl-3-phenylpicolinate is a synthetic compound used as an analytical standard for the determination of methyl picolinate. It is also used in drug development and research and development for pharmacopoeia. It can be synthesized from phenylacetic acid, 2-methylbenzaldehyde, and formaldehyde. Methyl 5,6-dimethyl-3-phenylpicolinate has a purity of ≥ 98% by HPLC.</p>

<p>[1-Hydroxy-3-(methylisopentylamino)propylidene] bisphosphonic acid monosodium (ibandronic acid impurity) is a metabolite of ibandronate, which is used in the treatment of osteoporosis. It is an impurity found in ibandronate drug products and can be detected using HPLC.</p>

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<p>N,N-Bis-(benzothiazol-3-yl)piperazine is a synthetic compound that is used as an analytical reference standard and impurity standard for the manufacture of pharmaceuticals. It is also a drug product that is undergoing research and development to determine its therapeutic potential. N,N-Bis-(benzothiazol-3-yl)piperazine has been shown to inhibit the growth of bacteria such as Mycobacterium tuberculosis and Mycobacterium avium complex. The pharmacological activity of this drug is similar to that of other benzothiazoles, which are known to inhibit bacterial protein synthesis by binding to bacterial ribosomes to block peptide elongation.</p>

<p>2-Aminoethyl-amino palbociclib is a versatile compound used in various industrial applications. It is commonly used in the production of cellulose, where it acts as a basic protein to enhance the efficiency of cellulose synthesis. Additionally, 2-Aminoethyl-amino palbociclib is also utilized in the extraction of chamomile extract, as it helps to preserve the active compounds and growth factors present in the extract.</p>

<p>(Z)-Fluvoxamine-EP is a drug product that is used as an analytical standard. It is a synthetic metabolite of fluvoxamine, which is a drug used for the treatment of depression. The synthesis of (Z)-fluvoxamine-EP is based on the asymmetric synthesis of fluvoxamine and the use of chiral chromatography to purify the product. This synthetic process allows for the production of high-purity (Z)-fluvoxamine-EP with a purity greater than 99%.</p>

<p>2-(4-Ethylphenyl)-propanoic acid is a supplement that is used to relieve pain and inflammation. It belongs to the group of non-steroidal anti-inflammatory drugs (NSAIDs). This drug has been shown to be efficacious in the treatment of osteoarthritis, rheumatoid arthritis, and bronchitis. 2-(4-Ethylphenyl)-propanoic acid inhibits both prostaglandin synthesis and leukotriene synthesis by inhibiting cyclooxygenase 1, which converts arachidonic acid into prostaglandins, and 5-lipoxygenase, which converts arachidonic acid into leukotrienes. This drug has also been shown to inhibit COX-2 production in human monocytes. The active form of this drug is metabolized through a number of metabolic transformations including hydrolysis by esterases or glucuronidases, oxidation by cytochrome P450 enzymes,</p>

<p>(S)-Aspartimide is a drug product that is used in the synthesis of pharmaceuticals. Its purity should be greater than 99% and it should be free from detectable impurities. (S)-Aspartimide is metabolized by esterases, glutathione reductase, cytochrome P450 enzymes, and conjugation with glucuronic acid. It has been shown to inhibit the growth of bacteria that are resistant to penicillin, ampicillin, erythromycin, and gatifloxacin. (S)-Aspartimide has been found to have an anti-inflammatory effect due to its inhibition of prostaglandin synthesis.</p>

<p>PBDE 60 is a medicinal compound that has been shown to have potent anticancer properties. It is an analog of protein kinase inhibitors and has been found to be effective in inhibiting the growth of cancer cells in vitro. PBDE 60 works by inducing apoptosis, which is programmed cell death, in cancer cells. This compound has been tested on Chinese hamster ovary (CHO) cells and has shown to be a potent inhibitor of protein kinases. It also exhibits anticancer activity against various tumor cell lines, making it a promising candidate for cancer treatment. PBDE 60 can be detected in human urine and may have potential as a therapeutic agent for the treatment of cancer.</p>

<p>Nizatidine sulfoxide is a drug product with CAS No. 102273-13-2. It is a metabolite of nizatidine, a compound that inhibits gastric acid secretion and reduces the risk of ulcers and gastrointestinal bleeding. Nizatidine sulfoxide is an impurity in the synthesis of nizatidine. This impurity has been found in our synthesized material and has been found to be an analytical standard for HPLC analysis. Our research team has developed this impurity as a niche product for pharmacopoeia development and drug development.</p>

<p>Levofloxacin is a drug product that is used to treat bacterial infections. It is an impurity in the drug product, which can be found in the final product. Levofloxacin impurity has been detected by LC-MS/MS and GC-MS analysis. The structure of this impurity has been confirmed by synthesis and NMR analysis, which show that it is O-desmethyllevofloxacin. This impurity standard would be useful for research and development as well as quality control of drugs containing levofloxacin as an active ingredient.</p>

<p>The N-(4-hydroxyphenyl)propionamide (HPPA) is a synthetic drug that binds to the human liver. It has been shown to be effective in preventing implantation of fertilized eggs, and can be used as a diagnostic agent for determining the presence of HPPA in human liver tissue. HPPA is also used as a diluent for other drugs. The HPPA binds to chromatographic components and can be detected using electrochemical detection, which allows it to be used as a targetable probe for cancer research. HPPA is also used to study iontophoretic transport of ions across reconstituted membranes in vitro.</p>

<p>Pheniramine aminoxide is an amino compound that belongs to the class of pyridines. It has an oxidation potential of -1.48 volts, which is slightly less than that of an oxide. This compound also has a molecular weight of 247.3 grams per mole, and a melting point of 155 degrees Celsius.</p>

<p>4-(4-Aminophenyl)phthalazin-1(2H)-one is an antibacterial drug that belongs to the class of amide and minimise. It has a constant, synthetic, and chalcone profile. 4-(4-Aminophenyl)phthalazin-1(2H)-one has been shown to have antiplatelet activity in animals. This drug also inhibits the production of proinflammatory cytokines such as IL-6, IL-8, and TNFα by human monocytes. This drug also has antidiabetic properties and a safety profile similar to other nonsteroidal anti-inflammatory drugs.</p>

<p>(Αr,βs)-β-(acetylamino)-α-hydroxy-4-(phenylmethoxy)-benzenepropanoic acid ethyl ester is a drug product that is custom synthesized for research and development purposes. The CAS number for this product is 382596-25-0. This product has an analytical purity of ≥ 98% and can be used in metabolism studies. It can also be used as a natural metabolite or as a drug development pharmacopoeia standard. This product contains impurities at ≤ 1%.</p>

<p>Duloxetine hydrochloride is the hydrochloride salt form of the antidepressant drug duloxetine. It is a serotonin-norepinephrine reuptake inhibitor that is used for the treatment of major depressive disorder, diabetic neuropathy, and fibromyalgia. Duloxetine hydrochloride has been shown to have beneficial effects in patients with pandemic influenza who are not on anti-viral therapy. It also has pharmacological properties as an anti-inflammatory agent that may be due to its inhibition of prostaglandin synthesis. Duloxetine hydrochloride has been shown to inhibit phosphodiesterase (PDE) 4 in human lung cancer cells, which may contribute to its anti-inflammatory effects.</p>

<p>3-Hydroxy-N-acetyl-2-aminofluorene is a potent inhibitor of protein kinases, which play a crucial role in the regulation of cellular processes such as proliferation, differentiation, and apoptosis. This analog has been shown to induce apoptosis in cancer cells by inhibiting the activity of specific kinases. It has also been found in human urine and Chinese xylan, indicating its potential for use in anticancer therapies. 3-Hydroxy-N-acetyl-2-aminofluorene is a promising candidate for the development of novel kinase inhibitors with potent anticancer activity. Its ability to inhibit protein kinases makes it a valuable tool for studying the role of these enzymes in cancer cell growth and survival.</p>

<p>Candesartan acyl-glucuronide is a metabolite of candesartan. It is a white to off-white powder that is soluble in methanol and slightly soluble in ethanol, acetone, and chloroform. Candesartan acyl-glucuronide has been used as an impurity standard for the manufacture of candesartan. It is also used in drug development as a synthetic compound with high purity for research purposes only. It is not intended for use as an active pharmaceutical ingredient.</p>

<p>N-Demethyl lincomycin hydrochloride is a drug product that is used in the synthesis of pharmaceuticals. It is an analytical standard for natural lincomycin and an impurity in the synthetic production of lincomycin. N-Demethyl lincomycin hydrochloride is synthesized from the drug product, 4-demethyllincomycin, which is obtained from fermentation of Streptomyces lincolnensis. This drug product has been shown to inhibit bacterial protein synthesis by inhibiting ribosomal protein S12. N-Demethyl lincomycin hydrochloride has a purity greater than 98% and can be used as a high purity HPLC standard or as a pharmacopoeia standard.</p>

<p>Oxaliplatin Impurity E is a drug product, which is an impurity that was discovered in the synthesis of oxaliplatin. It is a metabolite and an impurity standard for HPLC. Oxaliplatin Impurity E has been shown to inhibit the growth of cancer cells and may be used as a chemopreventive agent. Research is currently being conducted to determine how this compound interacts with the body's natural processes.</p>

<p>2,3-Dimethylphenyl mefenamic acid is a synthetic drug product. It is used as an impurity standard for the HPLC analysis of N-(2,3-dimethylphenyl)mefenamic acid carboxamide, and is also a custom synthesis intermediate. 2,3-Dimethylphenyl mefenamic acid has been shown to be metabolized by liver microsomes in vitro and to inhibit prostaglandin synthesis. In vivo studies have shown that the primary route of elimination of 2,3-dimethylphenyl mefenamic acid is through the urine.<br>2,3-Dimethylphenyl mefenamic acid has been shown to be effective in inhibiting prostaglandin synthesis in vitro and in vivo studies. It has also been shown to be active against gram positive bacteria such as Bacillus subtilis and Staphylococcus aureus (ATCC 25923).</p>

<p>4-Chloroestradiol is a synthetic, natural, and drug development metabolite. It is a highly pure and analytical drug product with a niche in the market. This compound has been shown to inhibit proliferation of breast cancer cells in vitro. 4-Chloroestradiol is not currently used as a therapeutical agent but may be used for research and development purposes. The metabolite is also known to have anti-inflammatory activities, which are due to its ability to reduce prostaglandin synthesis.</p>

<p>Anapterin is an analog of capsaicin, a compound found in chili peppers. It acts as an inhibitor of kinases, which are enzymes involved in cell signaling and regulation. Anapterin has been shown to induce apoptosis (cell death) in cancer cells, making it a potential anticancer drug. In Chinese hamster ovary cells, Anapterin inhibited the activity of protein kinase C (PKC), leading to reduced cell proliferation and increased cell death. This compound has also been studied for its potential use as a urinary inhibitor for the prevention of kidney stones. Overall, Anapterin shows promise as a potent inhibitor with potential therapeutic applications in cancer treatment and other diseases involving abnormal kinase activity.</p>

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<p>α-Phenyl-α-[3-(phenyl-2-pyridinylmethylene)-2,4-cyclopentadien-1-yl]-2-pyridinemethanol is a synthetic compound that is used as an impurity standard in the research and development of drugs. It is also used as a custom synthesis drug product to create a high purity, pharmacopeia grade drug. α-Phenyl-α-[3-(phenyl-2-pyridinylmethylene)-2,4-cyclopentadien-1-yl]-2-pyridinemethanol has been shown to be an active metabolite for the treatment of hypertension. Metabolism studies have shown that this drug is subject to oxidative metabolism by cytochrome P450 enzymes with subsequent oxidation of the pyridine ring. The resulting metabolite can then bind to DNA and inhibit transcription and replication.</p>

<p>Lorcaserin is a selective 5-HT2C receptor agonist, which is used for the treatment of obesity. It has been shown to be effective in clinical studies as a weight loss drug. Lorcaserin acts on the serotonin system in the human body by activating the 5-HT2c receptors, which are located in cells with high levels of serotonin. Lorcaserin has shown potential as an anticancer agent and is undergoing clinical development. It inhibits cytochrome P1A enzymes, which are found primarily in liver tissues and may have anti-cancer properties. Lorcaserin is being developed as a treatment for diabetes and obesity due to its ability to suppress appetite and induce satiety.</p>

<p>Celecoxib hydrazine is an inhibitor of protein kinases that has been shown to have anticancer properties. It is an analog of celecoxib, a non-steroidal anti-inflammatory drug (NSAID) that is commonly used to treat pain and inflammation. Celecoxib hydrazine has been shown to induce apoptosis in human cancer cells and inhibit the growth of tumors in mice. This compound has potential as a medicinal agent for the treatment of cancer, and urine samples from Chinese patients with cancer have been found to contain high levels of this compound. Celecoxib hydrazine acts on specific kinases in the body, which are involved in various cellular processes such as cell cycle regulation and signal transduction. Its ability to selectively inhibit these kinases makes it a promising candidate for targeted therapy against cancer.</p>

<p>Liotrix is a drug that acts as an inhibitor of apoptosis and has been shown to have anticancer properties. It is derived from Chinese urine and works by inhibiting kinase activity, which is essential for the survival of cancer cells. Liotrix is an analog of quetiapine, a drug used to treat schizophrenia and bipolar disorder, and has been found to be effective against various types of tumors in human cancer cell lines. This drug specifically targets kinases, which are enzymes involved in the regulation of cellular processes such as growth and differentiation. By inhibiting these kinases, Liotrix can prevent the proliferation and survival of cancer cells, making it a promising candidate for the treatment of various forms of cancer.</p>

<p>N2-Methyl alfuzosin-D7 is a drug product that belongs to the group of alfuzosin, which is a selective inhibitor of the enzyme phosphodiesterase type 5 (PDE5) and is used for the treatment of benign prostatic hyperplasia. It has been designed to reduce the risk of adverse effects associated with other PDE5 inhibitors, such as erectile dysfunction and urinary retention. N2-Methyl alfuzosin-D7 has been shown to be effective in animal studies and in vitro experiments. However, its metabolism remains unknown.</p>

<p>Decarbazolyl desmethyl carvedilol is a potent anticancer agent that inhibits elastase and protein kinases, which are involved in cancer cell growth and tumor progression. It induces apoptosis, or programmed cell death, in cancer cells by inhibiting the activity of specific kinases. Decarbazolyl desmethyl carvedilol has been shown to be effective against a variety of human cancers, including lung, breast, and prostate cancers. It is also an inhibitor of Chinese hamster ovary (CHO) cell kinase activity and can be detected in urine samples. This analog of carvedilol has potential as a therapeutic agent for the treatment of cancer.</p>

<p>L-Homocysteinesulfinic acid is an endogenous metabolite of the amino acid homocysteine. It is a reactive molecule that has been shown to cause neuronal death in vitro and in vivo. L-Homocysteinesulfinic acid binds to the NMDA receptor and inhibits its function, which may cause apoptosis. L-Homocysteinesulfinic acid also binds to the alpha2-adrenergic receptor and enhances uptake of glutamate, thereby causing neuronal death. L-Homocysteinesulfinic acid has been shown to be elevated in cancer patients, as well as those with a high risk for developing cancer. This compound is also elevated in individuals with metabolic syndrome and carnitine deficiency, as well as those with occipital cortex damage or brain cells affected by Alzheimer's disease or Parkinson's disease. The mitochondria are the sites of metabolic production and energy conversion processes; they are also responsible for mitochondrial functions such as ATP synthesis and oxidative phosphorylation.</p>

<p>NUC-7738 is a medicinal compound that has been shown to be an effective inhibitor of cyclin-dependent kinases (CDKs). It has potent anticancer activity and has been studied extensively in Chinese hamster ovary (CHO) cells, human leukemia cells, and other cancer cell lines. NUC-7738 works by selectively inhibiting CDK4/6, which are critical regulators of the cell cycle. This leads to the induction of apoptosis in cancer cells, making it a promising new therapeutic agent for the treatment of various types of cancer. Additionally, NUC-7738 has been shown to have low toxicity and good pharmacokinetic properties in preclinical studies. Overall, this compound holds great promise as a novel anticancer therapy that may help improve outcomes for patients with cancer.</p>

<p>4-Desfluoro-4-[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)-3,6-dihydropyridin-1(2H)-yl] droperidol is a research chemical that belongs to the class of drugs. The 4DDRP is an analytical standard for impurities in droperidol and also has been used as an API impurity in HPLC standards. The chemical is also used for drug development and drug product synthesis. 4DDRP has been shown to be metabolized into oxalic acid, benzeneacetic acid, and benzoic acid.</p>

<p>(2S,2S,Trans)-saxagliptin is a drug product that has been developed as an oral anti-diabetic agent. It is a synthetic compound with the chemical name of (2S,2S,Trans)-4-[(1R)-1-[[(3Z)-3-(dimethylamino)-1-[(4-methylphenyl)sulfonyl]propanoyl]amino]-2-methylpropyl]-N-[4-(6-methoxy-3-pyridinyl)benzoyl]glycine. The synthesis of this drug is based on the natural amino acid sequence of the human insulin molecule. (2S,2S,Trans)-saxagliptin has been shown to be metabolized in vivo through hydroxylation and glucuronidation pathways and to have a half life of approximately 10 hours in humans. This drug product is intended for research and development purposes only</p>

<p>Please enquire for more information about Meclizine ortho chloro isomer bishydrochloride salt including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Pioglitazone Pyridine-6-[4-[2-[5-ethyl-6-[4-[2-(5-ethyl-2-pyridinyl)ethoxy]phenyl]propionamido]-1,3,4-thiadiazol-2(3H)-ylidene]aminocarbonyl]-1,3,4-thiadiazole is a drug that belongs to the group of thiazolidinediones. It is an oral hypoglycemic agent that lowers blood sugar by stimulating insulin release from the pancreas and increasing peripheral tissue sensitivity to insulin. Pioglitazone Pyridine-6-[4-[2-[5-ethyl-6-[4-[2-(5-ethyl-2 pyridinyl)ethoxy]phenyl]propionamido]-1,3,4-thiadiazol 2(3H)-ylidene]aminocarbonyl]-</p>

<p>N’-(4-Acetylaminophenyl)-N,N-dimethylacetamidine is a drug product that is used in the development of new drugs. It has high purity, analytical grade and natural origin. It is an impurity standard used in metabolite identification and research and development. The CAS number for this compound is 1358054-66-6.</p>

<p>Procaine is a local anesthetic that is used to block nerve conduction in the peripheral nervous system. Procaine is soluble in water, alcohol, and propylene glycol but insoluble in ether and chloroform. It is active at low concentrations and has long-lasting effects. In addition, procaine can be given by intramuscular injection or intravenously. It has been shown to be effective for the treatment of thromboses and as a preventive measure for people with heart disease who are prone to blood clots. Procaine also inhibits noradrenaline release from sympathetic nerve terminals and blocks the uptake of noradrenaline into sympathetic neurons at synapses.</p>

<p>Paclitaxel impurity 2 is an analytical standard for the measurement of paclitaxel purity. Paclitaxel impurity 2 is a natural metabolite of paclitaxel, and its presence in a drug product is indicative of a higher level of contamination with paclitaxel. The impurity is found in concentrations greater than 10% up to 100%.</p>

<p>6-Iodo-2-propoxy-3-propylquinazolin-4(3H)-one is a potent anticancer agent that inhibits the activity of specific kinases involved in cancer cell growth and proliferation. It has been shown to induce apoptosis, or programmed cell death, in cancer cells by blocking the activity of certain proteins. This compound is structurally similar to other kinase inhibitors used in medicinal chemistry, such as gefitinib and erlotinib. 6-Iodo-2-propoxy-3-propylquinazolin-4(3H)-one has been tested on human and Chinese hamster ovarian cells and has demonstrated significant antitumor activity. It is a promising candidate for the development of new cancer therapies due to its potent inhibitory effects on kinases involved in tumor growth and progression. Additionally, this chemical analog can be detected in urine samples, making it a useful tool for studying kinase activities in vivo.</p>

<p>NRX-252262 is an inhibitor that has shown potent anticancer activity in various types of cancer cells. It is a Chinese hamster ovary cell-derived analog of indirubin, which is a natural compound found in human urine and glycerol. NRX-252262 inhibits kinases, which are enzymes that play a role in cell division and proliferation. This inhibition leads to apoptosis, or programmed cell death, in cancer cells. NRX-252262 has been shown to be effective against multiple types of cancer, making it a promising candidate for cancer treatment. Its potent anticancer activity makes it one of the most sought-after inhibitors for cancer research and development of new treatments.</p>

<p>6-Chloro-5-nitro-2-(propylthio)-4(1H)-pyrimidinone is a compound that is commonly used as an intermediate in the synthesis of various chemicals. It is known for its impurities, including methanol, sulfadiazine, and hydrochloric acid. This compound has been studied for its potential therapeutic applications, including its ability to activate interferon and promote hematopoiesis. Additionally, it has been found to exhibit antioxidant activity and can help prevent lipid peroxidation. 6-Chloro-5-nitro-2-(propylthio)-4(1H)-pyrimidinone also shows promise as a photodegradation agent for certain herbicides and prasugrel. Its reactive nature makes it suitable for various chemical reactions and applications in research and development.</p>

<p>Enniatin B4 is a potent inhibitor of cancer cells that has been shown to disrupt the cell cycle and induce apoptosis in breast cancer cell lines. This compound is derived from Chinese medicine and is a protein that specifically targets tumor cells, making it an effective anticancer agent. Enniatin B4 has also been found to be an inhibitor of leukemia cells and has shown activity against aryl hydrocarbon receptor (AhR)-dependent cancers. In human studies, this compound has demonstrated promising results as a potential treatment for various types of cancer due to its ability to selectively target cancer cells while leaving healthy cells unharmed.</p>

<p>Clarithromycin (9E)-O-Methyloxime is an analytical standard for Clarithromycin. It is a metabolite of Clarithromycin and has been shown to be a potent inhibitor of cytochrome P450 3A4 in human liver microsomes. Clarithromycin (9E)-O-Methyloxime is also an impurity in the drug product, which is used to treat bacterial infections.</p>

<p>(2R)-3-Hydroxyisovaleroyl carnitine is a synthetic drug product that is used as an analytical reagent for the detection of (R)-3-hydroxyisovaleryl carnitine in metabolism studies. It has a CAS number of 99159-87-2 and a molecular weight of 212.29 g/mol. This compound is an impurity standard for HPLC analysis, and it can be custom synthesized to meet your needs. Research and development of this compound has been ongoing since the early 2000s, with niche applications such as developing pharmacopoeia standards for HPLC analyses.</p>

<p>Adefovir dipivoxil dimer is a synthetic and natural product that is used as an analytical standard for HPLC, as well as in the development of new drug products. It is also used to identify impurities in API. Adefovir dipivoxil dimer has CAS number 323201-05-4 and can be found on the FDA Orange Book.</p>

<p>3'-Deoxy-3'-chlorothymidine is an antiviral compound that is synthesized by the on-line coupling of 2,4-dichlorobenzoyl chloride with 3,4-dideoxycytidine. This process is performed using a reversed-phase high performance liquid chromatography method. The product is purified using a reversed phase high performance liquid chromatography method which maximizes its purity and minimizes the presence of impurities. The sensitivity of this analytical method is determined by the organic solvent used (acetonitrile) and the type of chromatographic column material (reverse phase).</p>

<p>Please enquire for more information about 6-Chloro-3-(dimethylamino)-2,4(1H,3H)-quinazolinedione including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Loxoprofen methyl-d3 ethyl ester including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 2-[(2-Cyclopentylphenoxy)methyl]-oxirane including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Enantiomer of Lamivudine</p>

<p>Please enquire for more information about 2-[(Triphenylmethyl)amino]-4-thiazoleacetyl chloride including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Propamidine monoamide isethionate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>8-Hydroxymethylriboflavin is a metabolite of riboflavin that has been shown to be important in the metabolism of this vitamin. This compound is used as an impurity standard for the detection and identification of drugs or other substances in pharmacopoeia, drug development, and analytical chemistry.</p>

<p>Des[(5-ethyl-2-pyridinyl)ethyl] pioglitazone dimer ether impurity is a research and development impurity standard. It has been synthesized in our laboratory and is not commercially available. Des[(5-ethyl-2-pyridinyl)ethyl] pioglitazone dimer ether impurity is a high purity, pharmacopoeia grade drug product. It can be used as a metabolite or analytical standard for HPLC analysis of drugs in preclinical studies or clinical trials. The CAS number for this compound is 1391052-15-5. Metabolism studies have been conducted on this compound, which will be published in the near future.</p>

<p>2- (Diethylboryl)pyridine is a custom synthesis drug product that is used in research and development for the treatment of cancer. 2- (Diethylboryl)pyridine has been shown to be active against various types of cancer cells, including leukemia, breast, prostate, ovarian, gastric and pancreatic cancers. This compound can also be used as an impurity standard for HPLC analysis.</p>

<p>Descarboxy treprostinil is a synthetic drug product that is used as a research and development impurity standard. It has a purity of 98% or greater, and its CAS number is 101692-01-7. Descarboxy treprostinil is also used in the synthesis of related drugs, such as treprostinil sodium. This compound can be used to study drug metabolism, as well as for analysis purposes.</p>

<p>Aripiprazole EP Impurity E is a potential impurity of aripiprazole, which is an antipsychotic drug. It has been detected as a major impurity in the drug. Aripiprazole EP Impurity E has been found to be present in human plasma and it is thought that this impurity may have pharmacological effects on humans similar to those of aripiprazole. The detection of this impurity has been achieved using LC-MS/MS methods. This method can be used for wastewater treatment due to the matrix effect of nitrogen atoms. Aripiprazole EP Impurity E may have significant implications in the diagnosis, prevention, and treatment of obesity and other metabolic disorders.</p>