Angiogenèse
Les inhibiteurs de l'angiogenèse sont des composés qui interfèrent avec la formation de nouveaux vaisseaux sanguins, un processus crucial dans la croissance et la métastase des cancers. En inhibant l'angiogenèse, ces composés peuvent restreindre l'apport sanguin aux tumeurs, ralentissant ou arrêtant leur croissance. Les inhibiteurs de l'angiogenèse sont essentiels dans la recherche sur le cancer et le développement thérapeutique, offrant des informations sur les mécanismes de progression tumorale et proposant des traitements potentiels pour le cancer et d'autres maladies liées à l'angiogenèse. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de l'angiogenèse de haute qualité pour soutenir vos recherches en oncologie et biologie vasculaire.
Sous-catégories appartenant à la catégorie "Angiogenèse"
- BTK(157 produits)
- Bcr-Abl(112 produits)
- EGFR(595 produits)
- FAK(72 produits)
- FLT(88 produits)
- Récepteur du facteur de croissance des fibroblastes (FGFR)(178 produits)
- JAK(246 produits)
- PDGFR(126 produits)
- RAAS(91 produits)
- Src(81 produits)
- Syk(37 produits)
- Thrombine(52 produits)
- VDA(2 produits)
- VEGFR(252 produits)
Affichez 6 plus de sous-catégories
1981 produits trouvés pour "Angiogenèse"
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Mutated EGFR-IN-1
CAS :Mutated EGFR-IN-1 (Osimertinib analog) is a useful intermediate for the inhibitors design for mutated EGFR, such as L858R EGFR, Exonl9 deletion activatingFormule :C25H31N7ODegré de pureté :98.91%Couleur et forme :SolidMasse moléculaire :445.56Gancotamab
CAS :Gancotamab (MM-302) is a polyethylene glycolated liposome targeting HER2 with antitumor activity for the study of advanced HER2-positive breast cancer.Degré de pureté :96.7% (SDS-PAGE); 98.4% (SEC-HPLC) - 96.7% (SDS-PAGE); 98.4% (SEC-HPLC)Couleur et forme :LiquidLosatuxizumab
CAS :Losatuxizumab (ABT-806) is an anti-EGFR monoclonal antibody with potential anti-tumor activity for the study of advanced malignant solid tumors.Degré de pureté :97.3% (SDS-PAGE); 95.1% (SEC-HPLC) - 97.3% (SDS-PAGE); 95.1% (SEC-HPLC)Couleur et forme :LiquidALK inhibitor 2
CAS :ALK inhibitor 2 is a new-type and selective inhibitor for the ALK kinase.Formule :C23H28ClN7O3SDegré de pureté :99.77% - >99.99%Couleur et forme :SolidMasse moléculaire :518.03AG 1295
CAS :AG 1295 is a selective PDGFR tyrosine-kinase inhibitor; it blocks PDGFR autophosphorylation without affecting EGF receptor.Formule :C16H14N2Degré de pureté :99.64%Couleur et forme :SolidMasse moléculaire :234.3Aprutumab
CAS :<p>Aprutumab, a human FGFR2 monoclonal antibody, targets FGFR2-IIIB/C and is used in antibody-drug conjugates.</p>Degré de pureté :98.69% (SEC-HPLC) - 98.69% (SEC-HPLC)Couleur et forme :LiquidMasse moléculaire :150 kDaVadadustat
CAS :Vadadustat is a novel, titratable, oral hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor in development for the treatment of anemia.Formule :C14H11ClN2O4Degré de pureté :99.02% - 99.80%Couleur et forme :SolidMasse moléculaire :306.7Intetumumab
CAS :Intetumumab (CNTO 95) is a fully humanized anti-α(v)-integrin monoclonal antibody that is a radiosensitizer for xenograft tumor-bearing mice.Degré de pureté :97.6% (SDS-PAGE); 97.1% (SEC-HPLC) - 97.6% (SDS-PAGE); 97.1% (SEC-HPLC)Couleur et forme :LiquidMasse moléculaire :145.6 (kDa)JNJ-10198409
CAS :JNJ-10198409: selective ATP competitive PDGF-RTK inhibitor; IC50: PDGFR-β 4.2 nM, PDGFR-α 45 nM; antiangiogenic & antiproliferative.Formule :C18H16FN3O2Degré de pureté :98.51%Couleur et forme :SolidMasse moléculaire :325.34Amlexanox
CAS :Amlexanox (AA673) treats ulcers by blocking leukotrienes, histamine, reducing inflammation, pain, and healing time.Formule :C16H14N2O4Degré de pureté :99.67% - ≥95%Couleur et forme :White Crystalline SolidMasse moléculaire :298.29Chloropyramine hydrochloride
CAS :Chloropyramine hydrochloride (Alergosan) is a histamine receptor H1 antagonist.Formule :C16H20ClN3·HClDegré de pureté :99.45% - 99.8%Couleur et forme :SolidMasse moléculaire :326.26Lidocaine Hydrochloride hydrate
CAS :<p>Lidocaine Hydrochloride hydrate is an amide local anesthetic, has anti-inflammatory property.</p>Formule :C14H22N2O·HCl·H2ODegré de pureté :99.95%Couleur et forme :SolidMasse moléculaire :288.82AV-412
CAS :AV-412 (MP412) is an EGFR inhibitor (EGFR, EGFR T790M, EGFR L858R, EGFR L858R/T790M and ErbB2 with IC50s of 0.75, 0.79, 0.5, 2.3, 19 nM).Formule :C41H44ClFN6O7S2Degré de pureté :99.85% - 99.92%Couleur et forme :SolidMasse moléculaire :851.41Barecetamab
CAS :Barecetamab (ISU-104) is a humanized monoclonal antibody against tyrosine protein kinase ErbB3 with anticancer activity.Degré de pureté :97.1% (SDS-PAGE); 96.4% (SEC-HPLC) - 97.1% (SDS-PAGE); 96.4% (SEC-HPLC)Couleur et forme :LiquidTirabrutinib hydrochloride
CAS :Tirabrutinib hydrochloride is a potent, highly selective, irreversible oral BTK inhibitor.Cost-effective and quality-assured.Formule :C25H23ClN6O3Degré de pureté :99.27% - 99.95%Couleur et forme :SolidMasse moléculaire :490.94Triamcinolone acetonide
CAS :Triamcinolone acetonide (Azmacort) is a Corticosteroid.Formule :C24H31FO6Degré de pureté :99.61% - 99.91%Couleur et forme :White To Off-White Crystalline PowderMasse moléculaire :434.50N-(3-Aminopropyl)cyclohexylamine
CAS :N-(3-Aminopropyl)cyclohexylamine inhibits spermine synthase; used in neuro disease research.Formule :C9H20N2Degré de pureté :98.05% - 98.82%Couleur et forme :Pale Yellow Clear LiquidMasse moléculaire :156.2685Margetuximab
CAS :Margetuximab (MGAH-22) is a second generation anti-HER2 monoclonal antibody with anti-tumor activity.Degré de pureté :95.3% (SDS-PAGE); 99.3% (SEC-HPLC) - 95.3% (SDS-PAGE); 99.3% (SEC-HPLC)Couleur et forme :LiquidLyn-IN-1
CAS :Lyn-IN-1 (Bafetinib analog) is a selective and potent dual inhibitor of Bcr-Abl and LynFormule :C30H31F3N8ODegré de pureté :97% - 98.02%Couleur et forme :SolidMasse moléculaire :576.62O-Desmethyl gefitinib
CAS :O-Desmethyl gefitinib is an active EGFR inhibitor (IC50: 36 nM), a metabolite of Gefitinib, formed by CYP2D6.Formule :C21H22ClFN4O3Degré de pureté :97.17%Couleur et forme :SolidMasse moléculaire :432.88N-Desmethyl imatinib
CAS :N-Desmethyl imatinib (Imatinib metabolite N-Desmethyl imatinib) is a metabolite of Imatinib, which is a multi-target inhibitor of c-Kit, v-Abl, and PDGFR.Formule :C28H29N7ODegré de pureté :98.60%Couleur et forme :Off-White To Pale-Yellow SolidMasse moléculaire :479.58Pazopanib
CAS :Pazopanib (GW786034) is an inhibitor of protein tyrosine kinases that inhibits VEGFR1/2/3. Pazopanib has antitumor activity. Cost-effective and quality-assured.Formule :C21H23N7O2SDegré de pureté :98.78% - 99.85%Couleur et forme :White PowderMasse moléculaire :437.52Deferoxamine
CAS :Deferoxamine (Desferrioxamine B) is an iron chelator. Deferoxamine has antioxidant, anti-proliferative and anti-tumor activities. High-Quality, Low-Cost!Formule :C25H48N6O8Degré de pureté :99.66% - 99.97%Couleur et forme :SolidMasse moléculaire :560.68Sucralfate
CAS :Sucralfate (Sucrose octasulfate–aluminum complex) is a cytoprotective agent, an oral gastrointestinal medication primarily indicated for the treatment of activeFormule :C12H54Al16O75S8Degré de pureté :98%Couleur et forme :White Amorphous PowderMasse moléculaire :2086.75Lapatinib
CAS :Lapatinib (GW572016) is an inhibitor of ErbB2 and EGFR (IC50=9.2/10.8 nM) with oral activity.Formule :C29H26ClFN4O4SDegré de pureté :99.00% - 99.81%Couleur et forme :PowderMasse moléculaire :581.06Erlotinib
CAS :Erlotinib (NSC-718781) is an EGFR inhibitor (IC50: 2 nM). It is used for the treatment of non-small cell lung cancer.Formule :C22H23N3O4Degré de pureté :98.19% - 99.98%Couleur et forme :White To Off-White PowderMasse moléculaire :393.44Gefitinib
CAS :Gefitinib (ZD1839) is an EGFR first-generation inhibitor with oral activity that inhibits the EGFR 19 Del and L858R mutations.Formule :C22H24ClFN4O3Degré de pureté :99.92% - >99.99%Couleur et forme :Light-Yellow Crystalline PowderMasse moléculaire :446.9Bosutinib
CAS :Bosutinib (SKI-606) is a synthetic quinolone derivative and dual kinase inhibitor that targets both Abl (IC50: 1 nM) and Src (IC50: 1.2 nM) kinases.Formule :C26H29Cl2N5O3Degré de pureté :98.98% - 99.9%Couleur et forme :Yellowish-Orange Or Pink To Brownish Solid Solid PowderMasse moléculaire :530.45Naluzotan hydrochloride
CAS :<p>Naluzotan hydrochloride, a hERG K+ blocker (IC50: 3800 nM) and potent 5-HT1A agonist (IC50: ~20 nM, Ki: ~5.1 nM), is used in anxiety and depression studies.</p>Formule :C23H39ClN4O3SDegré de pureté :99.96%Couleur et forme :SolidMasse moléculaire :487.1Panitumumab
CAS :<p>Panitumumab is a fully human IgG2 monoclonal antibody targeting the epidermal growth factor receptor EGFR).</p>Degré de pureté :95% - 98.1% (SDS-PAGE); 99.4% (SEC-HPLC)Couleur et forme :LiquidMasse moléculaire :147 kDaLXH254
CAS :LXH254 is a B/C RAF inhibitor with IC50 values of 0.2 nM and 0.07 nM for inhibiting BRAF and CRAF.Cost-effective and quality-assured.Formule :C25H25F3N4O4Degré de pureté :98.3% - 99.92%Couleur et forme :SolidMasse moléculaire :502.49Naphazoline hydrochloride
CAS :Naphazoline hydrochloride (Naphazoline HCl) is an adrenergic vasoconstrictor agent used as a decongestant.Formule :C14H15ClN2Degré de pureté :97.93%Couleur et forme :White Crystalline Powder White Crystalline PowderMasse moléculaire :246.74Trastuzumab deruxtecan
CAS :<p>Trastuzumab deruxtecan (T-DXd) is an ADC with anticancer and antitumour activity that has been shown to improve gastric cancer.</p>Degré de pureté :95% - SEC-HPLC:98.49%Couleur et forme :LiquidMasse moléculaire :145 kDa (average)Oltipraz
CAS :Oltipraz (RP 35972) is a synthetic dithiolethione with potential chemopreventive and anti-angiogenic properties.Formule :C8H6N2S3Degré de pureté :98.79% - 99.77%Couleur et forme :SolidMasse moléculaire :226.34AZ7550 hydrochloride
CAS :<p>AZ7550 hydrochloride (AZ7550 hydrochloride ), an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).</p>Formule :C27H32ClN7O2Degré de pureté :99.65%Couleur et forme :SolidMasse moléculaire :522.04ALK-IN-26
CAS :<p>ALK-IN-26 is an ALK inhibitor with potential anticancer activity.ALK-IN-26 shows antiproliferative activity against glioblastoma.</p>Formule :C24H23NO3SDegré de pureté :99.91%Couleur et forme :SoildMasse moléculaire :405.51Ascrinvacumab
CAS :Ascrinvacumab (PF-03446962): humanized IgG2 anti-ALK-1 antibody, Kd 7 nM, inhibits TGF-β, for HCC research.Degré de pureté :SDS-PAGE:95% SEC-HPLC:98.18%Couleur et forme :LiquidMasse moléculaire :150 kDaPetosemtamab
CAS :<p>Petosemtamab (MCLA 158), a dual-action monoclonal antibody targets EGFR & LGR5, used in solid tumor research like HNSCC & CRC.</p>Degré de pureté :> 95% - > 95%Couleur et forme :LiquidMasse moléculaire :145.97 kDaParsatuzumab
CAS :Parsatuzumab (RG 7414), a monoclonal antibody targeting EGFL7, an immunomodulator.Parsatuzumab inhibits the interaction of EGFL7 with endothelial cells.Degré de pureté :> 95% - > 95%Couleur et forme :LiquidMasse moléculaire :148.22 kDaALK inhibitor 1
CAS :ALK inhibitor 1 is a selective ALK kinase inhibitor.Formule :C23H28BrN7O3SDegré de pureté :98.27%Couleur et forme :SolidMasse moléculaire :562.48FGFR1/DDR2 inhibitor 1
CAS :FGFR1/DDR2 inhibitor 1 is an inhibitor of discoindin domain receptor 2 (DDR2) and fibroblast growth factor receptor 1 (FGFR1), with IC50 values of 31.1 nM, 108Formule :C28H22F3N5ODegré de pureté :99.43%Couleur et forme :SolidMasse moléculaire :501.5Hck-IN-1
CAS :Hck-IN-1 selectively inhibits Nef:Hck, IC50: 2.8 μM; >20 μM for Hck alone. Potent HIV-1 Nef antagonist, IC50: 100-300 nM for HIV-1 replication.Formule :C16H11ClN6O3SDegré de pureté :99.07%Couleur et forme :SolidMasse moléculaire :402.81Trapidil
CAS :Trapidil (Avantrin) is a coronary vasodilator agent.Formule :C10H15N5Degré de pureté :99.42%Couleur et forme :SolidMasse moléculaire :205.26Tirbanibulin Mesylate
CAS :Tirbanibulin Mesylate (KX01 Mesylate) is an inhibitor of Src that targets the peptide substrate site of Src (GI50: 9-60 nM in cancer cell lines).Formule :C27H33N3O6SDegré de pureté :99%Couleur et forme :SolidMasse moléculaire :527.63Lanraplenib
CAS :Lanraplenib (GS-9876) is a highly selective and orally active SYK inhibitor (IC50=9.5 nM) in development for the treatment of inflammatory diseases.Formule :C23H25N9ODegré de pureté :98.35%Couleur et forme :SolidMasse moléculaire :443.5Tinengotinib
CAS :Tinengotinib is a multikinase inhibitor that targets a series of kinases , including Aurora kinases A/B, JAK1/2, FGFR1/2/3, VEGFRs, and many other kinases.Formule :C20H19ClN6ODegré de pureté :99.05%Couleur et forme :SolidMasse moléculaire :394.86Sorafenib
CAS :Sorafenib (Bay 43-9006) is a multikinase inhibitor that inhibits Raf-1, B-Raf, VEGFR2, VEGFR3, VEGFR4, PDGFRβ, FLT3, c-Kit, and others (IC50=6/22/90/15/20/20/57Formule :C21H16ClF3N4O3Degré de pureté :98% - 99.89%Couleur et forme :SolidMasse moléculaire :464.82AS-1763
CAS :AS-1763 is an orally available and selective BTK inhibitor with an IC50 of 0.85 nM.Formule :C33H31FN6O3Degré de pureté :≥95%Couleur et forme :SolidMasse moléculaire :578.64HyT36
CAS :<p>HyT36: hydrophobic tag that destabilizes fusion proteins & Her3 pseudokinase; treats cells with acute erht.</p>Formule :C25H44ClNO3Degré de pureté :99.86%Couleur et forme :SolidMasse moléculaire :442.07Carvedilol phosphate hemihydrate
CAS :Carvedilol phosphate hemihydrate (BM 14190 phosphate hemihydrate) is the phosphate salt form of carvedilol, a racemic mixture and adrenergic blocking agent.Formule :C24H26N2O4·5H2O·H3O4PDegré de pureté :99.24% - 99.98%Couleur et forme :SolidMasse moléculaire :513.49Ilginatinib hydrochloride
CAS :Ilginatinib hydrochloride (NS-018 hydrochloride) is a highly active and orally bioavailable inhibitor of JAK2.Formule :C21H21ClFN7Degré de pureté :99.55%Couleur et forme :SolidMasse moléculaire :425.89FLT3-IN-3
CAS :FLT3-IN-3 is an effective FLT3 inhibitor, and the IC50s of FLT3 WT and FLT3 D835Y are 13 and 8 nM, respectively.Formule :C27H38N8ODegré de pureté :99.25%Couleur et forme :SolidMasse moléculaire :490.64Btk inhibitor 2
CAS :Btk inhibitor 2 (BGB-3111 analog) is a BTK inhibitor.Formule :C24H25N5O3Degré de pureté :99.94%Couleur et forme :SolidMasse moléculaire :431.49Allitinib
CAS :Allitinib (AST-1306) (AST-1306) has anti-cancer activity，and it is an irreversible EGFR and ErbB2 inhibitor with IC50s of 0.5 and 3 nM, respectively. [1]Formule :C24H18ClFN4O2Degré de pureté :99.89% - 99.91%Couleur et forme :SolidMasse moléculaire :448.88Pamufetinib
CAS :Pamufetinib (TAS-115) is a potent inhibitor of VEGFR and hepatocyte growth factor receptor (c-Met/HGFR)-targeted kinase.Formule :C27H23FN4O4SDegré de pureté :99.39%Couleur et forme :SolidMasse moléculaire :518.56Axitinib
CAS :Axitinib (AG-013736) is a multi-targeted tyrosine kinase inhibitor that inhibits VEGFR1/2/3 and PDGFRβ. Axitinib has antitumor activity. Cost-effective and quality-assured.Formule :C22H18N4OSDegré de pureté :98.9% - 99.74%Couleur et forme :Off-White SolidMasse moléculaire :386.47Lenvatinib
CAS :Lenvatinib (E7080) is a multi-target receptor tyrosine kinase inhibitor that inhibits VEGFR1-3, FGFR1-4, KIT, PDGFR, and RET, and has oral activity.Formule :C21H19ClN4O4Degré de pureté :98.46% - 99.96%Couleur et forme :SolidMasse moléculaire :426.85Formononetin
CAS :Formononetin (Flavosil) is an O-methylated isoflavone and a phytoestrogen from the root of Astragalus membranaceus.Formule :C16H12O4Degré de pureté :97.39% - 99.94%Couleur et forme :SolidMasse moléculaire :268.26MT-802
CAS :MT-802 is an effective BTK degrader based on PROTAC technology (DC50: 1 nM). MT-802 has the potential to treat C481S mutant chronic lymphocytic leukemia (CLL).Formule :C41H41N9O8Degré de pureté :95.93% - 97%Couleur et forme :SolidMasse moléculaire :787.82Dasatinib monohydrate
CAS :Dasatinib monohydrate, an oral SRC-kinase inhibitor, counters imatinib-resistant chronic myeloid leukemia.Formule :C22H28ClN7O3SDegré de pureté :99.68% - >99.99%Couleur et forme :SolidMasse moléculaire :506.03YS-67
CAS :YS-67 is an orally available, selective and potent EGFR inhibitor with antitumor activity, inhibits p-EGFR and p-AKT, and inhibits the proliferation of A549, PC-9, and A431 cells.YS-67 blocks cell cycle progression and induces apoptosis in the G0/G1 phase, and can be used in the study of non-small-cell lung cancer.Formule :C32H34N4O3Degré de pureté :98.88%Couleur et forme :SoildMasse moléculaire :522.64MRX-2843
CAS :MRX-2843 (UNC2371) is a potent and orally active inhibitor of MERTK and FLT3(IC50s of 1.3 nM and 0.64 nM, respectively).Formule :C29H40N6ODegré de pureté :98.59% - 99.63%Couleur et forme :SolidMasse moléculaire :488.67Ibuprofen
CAS :<p>Ibuprofen, an NSAID, reduces pain, inflammation, and fever by limiting prostaglandin production.</p>Formule :C13H18O2Degré de pureté :99.7% - 99.81%Couleur et forme :Colorless Solid CrystallineMasse moléculaire :206.28Pemigatinib
CAS :Pemigatinib (INCB054828) is an orally active, selective inhibitor of FGFR(IC50s of 0.4 nM, 0.5 nM, 1.2 nM, 30 nM for FGFR1, FGFR2, FGFR3, FGFR4, respectively).Formule :C24H27F2N5O4Degré de pureté :99.57% - 99.95%Couleur et forme :SolidMasse moléculaire :487.5Chloramphenicol
CAS :<p>Chloramphenicol (Chloromycetin) is a broad-spectrum antibiotic that inhibits the biosynthesis of bacterial proteins. Cost-effective and quality-assured.</p>Formule :C11H12Cl2N2O5Degré de pureté :99.6% - 99.84%Couleur et forme :Needles Or Elongated Plates From Water Or Ethylene Dichloride SolidMasse moléculaire :323.13Hexylresorcinol
CAS :Hexylresorcinol (4-Hexylresorcinol) is a substituted dihydroxybenzene used topically as an antiseptic for the treatment of minor skin infections.Formule :C12H18O2Degré de pureté :99.26% - 99.51%Couleur et forme :Solid Solid Particulate/PowderMasse moléculaire :194.27Albendazole
CAS :Albendazole (SKF-62979) is used as a drug indicated for the treatment of a variety of worm infestations.Formule :C12H15N3O2SDegré de pureté :98.21% - 98.76%Couleur et forme :Colorless Crystals SolidMasse moléculaire :265.33Ponatinib Hydrochloride
CAS :<p>Ponatinib Hydrochloride (AP-24534 Hydrochloride) is a hydrochloride of ponatinib.</p>Formule :C29H28ClF3N6ODegré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :569.02Thiabendazole
CAS :<p>Thiabendazole (2-(4-Thiazolyl)benzimidazole) is a benzimidazole derivative with anthelminthic property.</p>Formule :C10H7N3SDegré de pureté :99.14%Couleur et forme :Light Yellow PowderMasse moléculaire :201.25PTC299
CAS :<p>PTC299 ((4-chlorophenyl) (1S)-6-chloro-1-(4-methoxyphenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indole-2-carboxylate) is an orally active inhibitor of VEGFA mRNA</p>Formule :C25H20Cl2N2O3Degré de pureté :99.72%Couleur et forme :SolidMasse moléculaire :467.34LC-MB12
CAS :<p>LC-MB12 is a PROTAC FGFR2 compound that degrades FGFR2 and can be used to study gastric cancer.</p>Formule :C43H44Cl2N10O8Degré de pureté :99.16%Couleur et forme :SolidMasse moléculaire :899.78SB220025
CAS :SB220025 is a P38 mitogen-activated protein kinase inhibitor that inhibits p56Lck and PKC, and inhibits angiogenesis.Formule :C18H19FN6Degré de pureté :99.44%Couleur et forme :SolidMasse moléculaire :338.38ZX-29
CAS :ZX-29: Strong ALK inhibitor; IC50 - ALK 2.1 nM, L1196M 1.3 nM, G1202R 3.9 nM; triggers autophagy; anti-cancer.Formule :C23H28ClN7O3SDegré de pureté :98.32%Couleur et forme :SolidMasse moléculaire :518.03JI6
CAS :<p>JI6 (JAK3 Inhibitor VI) is a potent, selective and orally active FLT3 inhibitor.</p>Formule :C19H17N3O4SDegré de pureté :98.51%Couleur et forme :SoildMasse moléculaire :383.42Patritumab
CAS :<p>Patritumab (U3-1287), an anti-HER3 antibody, may inhibit tumor growth and cancer cell division in non-small cell lung cancer.</p>Degré de pureté :95.2%Couleur et forme :LiquidMasse moléculaire :146.97 kDaIcrucumab
CAS :Icrucumab, a humanized antibody, inhibits VEGFR-1 and shows antitumor effects, tested in metastatic colon cancer.Degré de pureté :> 95%Couleur et forme :LiquidMasse moléculaire :150 kDaOlaratumab
CAS :<p>Olaratumab(IMC-3G3) is a human monoclonal IgG1 antibody against platelet-derived growth factor receptor alpha (PDGFRα), which has antitumor effects and can be</p>Degré de pureté :SDS-PAGE:95% SEC-HPLC:98.70%Couleur et forme :LiquidMasse moléculaire :147.12 kDaTrastuzumab emtansine
CAS :Trastuzumab emtansine is a HER2-targeted ADC for advanced breast cancer, combining trastuzumab with DM1 cytotoxicity.Degré de pureté :98%Couleur et forme :LiquidSNIPER(ABL)-015
SNIPER(ABL)-015, a compound that conjugates GNF5 (ABL inhibitor) to MV-1 (IAP ligand) via a linker, effectively reduces BCR-ABL protein levels with a DC50 of 5Formule :C58H70F3N9O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1094.23BTK-IN-5
CAS :<p>BTK-IN-5 is a covalent inhibitor of Bruton's tyrosine kinase (BTK) designed for the treatment of medical conditions including cardiovascular diseases,</p>Formule :C23H32N4O5Couleur et forme :SolidMasse moléculaire :444.532TYK2 activator-1
<p>TYK2activator-1 (16b) is a TYK2 activator with an EC50 value of 1.78 μM. It inhibits JAK2 and JAK3 with IC50 values of 6.8 μM and 6.3 μM, respectively.</p>Formule :C23H21FN4O2Couleur et forme :SolidMasse moléculaire :404.16485ALK-IN-9
CAS :<p>ALK-IN-9 effectively inhibits cell growth with IC50 <0.2 nM for Ba/F3-EML4-ALK, KM12, KG-1.</p>Formule :C20H21FN6O3Couleur et forme :SolidMasse moléculaire :412.425SI-2
CAS :SI-2, a SRC-3 inhibitor, triggers breast cancer cell death (IC50: 3-20 nM), sparing normal cells.Formule :C15H15N5Degré de pureté :98.4%Couleur et forme :SolidMasse moléculaire :265.31K882
K882 (Compound 4e) is an Src inhibitor with a KD of 0.315 μM. It induces apoptosis and inhibits XIAP and Survivin. Additionally, K882 blocks the activation of the PI3K/Akt/mTOR, Jak1/Stat3, and Ras/MAPK signaling pathways. K882 exhibits antitumor activity against non-small cell lung cancer.Formule :C18H16N2O2Couleur et forme :SolidMasse moléculaire :292.33MPT0B390
CAS :<p>MPT0B390 is an inhibitor of HDAC and a TIMP3 inducer inhibiting tumor growth, metastasis, and angiogenesis.</p>Formule :C17H17N3O5SDegré de pureté :99.4%Couleur et forme :SolidMasse moléculaire :375.4HIF-1 Signaling Pathway Compound Library
<p>A unique collection of 1336 HIF-1 related small chemicals can be used for drug discovery in ischemic disease and cancer and related mechanism studies；</p>Couleur et forme :Odour SolidHIF-1 inhibitor-4
CAS :<p>HIF-1 inhibitor-4 (HIF-1 inhibitor-4) is a HIF-1 inhibitor with IC50 of 560 nM.</p>Formule :C18H19IN2O2Degré de pureté :99.26%Couleur et forme :SolidMasse moléculaire :422.26INCB-000928
CAS :<p>Zilurgisertib (INCB-000928) is a selective and potent ALK 2 inhibitor for the study of cancer and MF anemia.</p>Formule :C30H38N4O3Degré de pureté :98.93%Couleur et forme :SolidMasse moléculaire :502.65SNIPER(ABL)-033
CAS :SNIPER(ABL)-033, a compound that conjugates HG-7-85-01 (ABL inhibitor) to a LCL161 derivative (IAP ligand) via a linker, effectively reduces BCR-ABL proteinFormule :C61H73F3N10O9S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1211.42FAK-IN-24
CAS :FAK-IN-24 (Compound 9f) is a potent FAK inhibitor with an IC50 of 0.815 nM. It induces DNA damage and apoptosis, and exhibits activity against glioblastoma. FAK-IN-24 effectively inhibits proliferation of glioblastoma cell lines U87-MG (IC50= 15 nM) and U251 (IC50= 20 nM), and suppresses tumor growth in U87-MG xenograft models.Formule :C39H45Cl2F3N8O3Couleur et forme :SolidMasse moléculaire :801.728SNIPER(ABL)-050
SNIPER(ABL)-050 is a chemical compound that combines Imatinib, an ABL inhibitor, with MV-1, an IAP ligand, using a linker.Formule :C68H84N12O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1213.47Angiogenesis related Compound Library
<p>A unique collection of 1353 proangiogenic and antiangiogenic compounds for new targets identification, research in mechanisms of angiogenesis, and high</p>Couleur et forme :Odour SolidSorafenib-d4
CAS :<p>Sorafenib D4 is deuterium-labeled Sorafenib, a multi-kinase inhibitor (Raf-1, B-Raf, VEGFR-3) with IC50s: 6, 20, 22 nM.</p>Formule :C21H16ClF3N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :468.85EGFR-IN-22
CAS :<p>EGFR-IN-22: potent for EGFR (IC50: 4.91 nM) & L858R/T790M/C797S mutation (IC50: 0.54 nM).</p>Formule :C38H47BrFN10O2PCouleur et forme :SolidMasse moléculaire :805.72AG-1478 hydrochloride
CAS :AG1478 HCl is an epidermal growth factor receptor protein inhibitor.Formule :C16H15Cl2N3O2Couleur et forme :SolidMasse moléculaire :352.21EGFR/HER2/DHFR-IN-3
EGFR/HER2/DHFR-IN-3 (compound 4c) serves as an efficacious dual inhibitor specifically targeting EGFR/HER2, exhibiting IC50 values of 0.138 μM for EGFR and 0.Degré de pureté :98%Couleur et forme :Odour SolidDB1113
CAS :DB1113 is a bifunctional kinase degrader, targeting ABL1, ABL2, CDK4, MAPKs, and more for disease research.Formule :C59H68F3N13O6SCouleur et forme :SolidMasse moléculaire :1144.31Apoptosis inducer 35
<p>Apoptosisinducer 35 (Compound 6) is a multi-target inhibitor that reduces the expression of EGFR, AKT, ERK, and P38-MAPKα. It suppresses the proliferation of cancer cells A549 and Jurkat, induces cell cycle arrest at the S phase, and triggers apoptosis (cell death).</p>Formule :C23H21ClN8O2S2Couleur et forme :SolidMasse moléculaire :541.048MLK3-IN-1
<p>MLK3-IN-1 (Compound 37) is a selective inhibitor of mixed-lineage kinase 3 (MLK3) with an IC50 of less than 1 nM. It also inhibits FAK with an IC50 of 15.5 μM. In both murine and human liver microsomes, MLK3-IN-1 demonstrates excellent metabolic stability.</p>Formule :C20H16F6N4O2SCouleur et forme :SolidMasse moléculaire :490.422TYD-68
<p>TYD-68 is a potent and selective CRBN-recruiting TYK2 PROTAC degrader, with a DC50 value of 0.42 nM. This compound effectively inhibits IL-12 and IFN-α-induced phosphorylation of STAT4 and STAT1, thereby blocking TYK2-dependent signaling pathways. TYD-68 is applicable in psoriasis research.</p>Couleur et forme :Odour Solid
