Angiogenèse
Les inhibiteurs de l'angiogenèse sont des composés qui interfèrent avec la formation de nouveaux vaisseaux sanguins, un processus crucial dans la croissance et la métastase des cancers. En inhibant l'angiogenèse, ces composés peuvent restreindre l'apport sanguin aux tumeurs, ralentissant ou arrêtant leur croissance. Les inhibiteurs de l'angiogenèse sont essentiels dans la recherche sur le cancer et le développement thérapeutique, offrant des informations sur les mécanismes de progression tumorale et proposant des traitements potentiels pour le cancer et d'autres maladies liées à l'angiogenèse. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de l'angiogenèse de haute qualité pour soutenir vos recherches en oncologie et biologie vasculaire.
Sous-catégories appartenant à la catégorie "Angiogenèse"
- BTK(167 produits)
- Bcr-Abl(118 produits)
- EGFR(581 produits)
- FAK(72 produits)
- FLT(86 produits)
- Récepteur du facteur de croissance des fibroblastes (FGFR)(180 produits)
- JAK(243 produits)
- PDGFR(129 produits)
- RAAS(89 produits)
- Src(82 produits)
- Syk(37 produits)
- Thrombine(57 produits)
- VDA(2 produits)
- VEGFR(242 produits)
Affichez 6 plus de sous-catégories
2387 produits trouvés pour "Angiogenèse"
Trier par
Degré de pureté (%)
0
100
|
0
|
50
|
90
|
95
|
100
BCR-ABL-IN-4
CAS :BCR-ABL-IN-4: Anticancer BCR-ABL inhibitor; stops K562 cells (IC50: 0.67 nM), targets T315I Ba/F3 cells (IC50: 16 nM).Formule :C27H24ClF2N5O4Couleur et forme :SolidMasse moléculaire :555.96Atiprimod (free base)
CAS :Atiprimod: an oral azaspirane inhibiting STAT3, blocking IL-6/VEGF pathways, and promoting apoptosis by downregulating Bcl-2 and Mcl-1.Formule :C22H44N2Couleur et forme :SolidMasse moléculaire :336.62′-Thioadenosine
CAS :2'-Thioadenosine (PD157432) serves as a selective and irreversible inhibitor of ErbB-1 and ErbB-2 tyrosine kinases, demonstrating an IC50 value of 45 µM againstFormule :C10H13N5O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :283.31Pirtobrutinib
CAS :Pirtobrutinib: a selective, non-covalent BTK inhibitor effective against BTK C481 mutations, causing tumor regression in lymphoma models.Formule :C22H21F4N5O3Degré de pureté :99.76% - 99.94%Couleur et forme :SolidMasse moléculaire :479.43Ref: TM-T36287
1mg34,00€5mg74,00€1mL*10mM (DMSO)79,00€10mg119,00€25mg268,00€50mg411,00€100mg605,00€500mg1.288,00€BTK-IN-17
BTK-IN-17: selective, oral BTK inhibitor, IC50=13.7 nM, reduces p-BTK Y223/p-PLCγ2 Y1217, anti-inflammatory.Formule :C26H23N7O2Couleur et forme :SolidMasse moléculaire :465.51FLT3-IN-14
CAS :FLT3-IN-14: FLT3 inhibitor; FLT3-WT IC50=5.6nM, FLT3-ITD IC50=1.4nM; blocks Y591 phosphorylation; G1 arrest; pro-apoptotic.Formule :C25H24N6O2SCouleur et forme :SolidMasse moléculaire :472.56JAK-IN-17
"JAK-IN-17: Potent JAK inhibitor for studying ocular, skin, and respiratory diseases."Formule :C33H38F2N6O8Couleur et forme :SolidMasse moléculaire :684.69ALK/EGFR-IN-1
CAS :ALK/EGFR-IN-1 (Compound 8l) is a dual inhibitor targeting both ALK and EGFR, effectively blocking their phosphorylation.Formule :C27H34ClN7O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :572.12BTK-IN-18
CAS :BTK-IN-18 is a potent, reversible inhibitor of Bruton's tyrosine kinase (BTK) with an inhibitory concentration (IC50) of 0.002 µM.Formule :C20H22Cl2N6OCouleur et forme :SolidMasse moléculaire :433.33EGFR-IN-29
CAS :EGFR-IN-29 is a potent EGFR inhibitor.Formule :C36H46BrN8O2PCouleur et forme :SolidMasse moléculaire :733.68(Rac)-PF-06250112
CAS :(Rac)-PF-0625011 is a racemic mix, orally active, selective BTK inhibitor, also targeting BMX and TEC kinases.Formule :C22H20F2N6O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :438.43EVT801
CAS :EVT801 is a highly selective and low-toxic VEGFR-3 inhibitor that inhibits VEGF-C-induced tumor lymphoid and angiogenesis and reduces CCL4, CCL5 and MDSC.Formule :C19H21N5O3Degré de pureté :97.4%Couleur et forme :SolidMasse moléculaire :367.4Ref: TM-T73516
1mg154,00€5mg371,00€1mL*10mM (DMSO)409,00€10mg595,00€25mg1.251,00€50mg1.963,00€100mg3.132,00€JAK-IN-24
CAS :JAK-IN-24: JAK inhibitor, IC50: 0.534 nM (4 μM ATP), 24 nM (1mM ATP), STAT5 phosphorylation IC50: 86.171 nM.Formule :C20H25N5O2Couleur et forme :SolidMasse moléculaire :367.44SNIPER(TACC3)-11
CAS :SNIPER(TACC3)-11 is a powerful FGFR3-TACC3 protein degrader, reducing its amount and hindering FGFR3-TACC3+ cancer cell growth.Formule :C51H66N10O7S2Couleur et forme :SolidMasse moléculaire :995.26HDAC-IN-50
CAS :HDAC-IN-50, a potent FGFR/HDAC inhibitor (IC50: 0.18-13 nM), induces apoptosis, cell cycle arrest, and shows anti-tumor activity.Formule :C31H41N7O4Couleur et forme :SolidMasse moléculaire :575.7SD 1008
CAS :SD 1008 is a JAK2/STAT3 signaling pathway inhibitor. SD 1008 inhibits activation of STAT3, JAK2, and Src.Formule :C18H19NO5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :329.35MET kinase-IN-3
CAS :MET kinase-IN-3 is a potent, orally active MET inhibitor (IC50: 9.8 nM) that exhibits good broad-spectrum anti-proliferative effects on cancer cells.Formule :C25H16ClF2N5O2Couleur et forme :SolidMasse moléculaire :491.88BTK-IN-19
CAS :BTK-IN-19 is a reversible BTK inhibitor with an IC 50 of <0.001 μM .Formule :C21H22Cl2N6OCouleur et forme :SolidMasse moléculaire :445.35BTK inhibitor 20
CAS :BTK inhibitor 20 is a potent BTK inhibitor with an IC 50 of 8 nM .Formule :C37H42N8O4Couleur et forme :SolidMasse moléculaire :662.78BTK-IN-11
CAS :BTK-IN-11: potent BTK inhibitor; may research autoimmune, inflammatory diseases, cancer. (Patent WO2022063101A1, Z2)Formule :C26H22ClN5O3Couleur et forme :SolidMasse moléculaire :487.94CP-547632 TFA
CAS :CP-547632 TFA, an oral VEGFR-2 and FGF inhibitor, IC50: VEGFR-2 at 11 nM, FGF at 9 nM, shows antitumor activity.Formule :C22H25BrF5N5O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :646.43HDAC/JAK/BRD4-IN-1
CAS :HDAC/JAK/BRD4-IN-1 (compound 25ap) is a potent triple inhibitor targeting HDAC, JAK, and BRD4.Formule :C24H28N6O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :448.52Tyk2-IN-9
CAS :Tyk2-IN-9: selective Tyk-2 inhibitor, IC50 of 0.076 nM (TYK2-JH2), 1.8 nM (JAK1-JH2), for inflammation/autoimmune research.Formule :C20H17N9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :383.41EGFR-IN-36
CAS :EGFR-IN-36 inhibits EGFR, HER2, & mutants with IC50s: 19.09 nM (EGFR WT), 120.01 nM (HER2 WT), 2.35 nM (HER2 mutant).Formule :C26H25ClN6O2Couleur et forme :SolidMasse moléculaire :488.97ALK/EGFR-IN-3
CAS :ALK/EGFR-IN-3 is a dual ALK and EGFR inhibitor that demonstrates potent anti-proliferative effects on various cancer cell lines, including H1975, PC9, and Baf3-Formule :C27H34ClN7O3SCouleur et forme :SolidMasse moléculaire :572.12SG3-179
CAS :SG3-179 is a BET inhibitor.Formule :C28H35ClFN7O3SCouleur et forme :SolidMasse moléculaire :604.14Infigratinib-Boc
CAS :Infigratinib-Boc, a derivative of the ATP-competitive pan-FGFR inhibitor Infigratinib, incorporates a Boc (t-Butyloxy carbonyl) group [1].Formule :C29H35Cl2N7O5Couleur et forme :SolidMasse moléculaire :632.54ALK/EGFR-IN-2
CAS :ALK/EGFR-IN-2 is a potent dual inhibitor targeting ALK and EGFR, promoting apoptosis and G0/G1 cell cycle arrest in cancer cells.Formule :C27H34ClN7O3SCouleur et forme :SolidMasse moléculaire :572.12EGFR-IN-71
CAS :EGFR-IN-71 is a potent inhibitor of epidermal growth factor receptor (EGFR) (IC50= 3.7 μM). EGFR-IN-71 has research value in chordoma.Formule :C16H9ClIN3Couleur et forme :SolidMasse moléculaire :405.62MTP
CAS :MTP, a PKM2 inhibitor, promotes apoptosis in cancer cells via caspase-3 activation while also inducing autophagy and enhancing ROS generation.Formule :C29H23F3N4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :516.51TAK-659
CAS :TAK-659 is a spleen tyrosine kinase (SYK) inhibitor.Formule :C17H21FN6ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :344.39FLT3/ITD-IN-5
CAS :FLT3/ITD-IN-5 (Example 6) is an orally active inhibitor of both FLT3 and FLT3-ITD, exhibiting IC50 values of 0.088 nM and 0.348 nM, respectively. This compound is utilized in cancer research.Formule :C23H25N7O2Couleur et forme :SolidMasse moléculaire :431.49HIF-2α-IN-1
CAS :HIF-2α-IN-1 is a potent HIF-2α inhibitor with IC50 values less than 500 nM.Formule :C16H8F5NO4SDegré de pureté :97.99%Couleur et forme :SolidMasse moléculaire :405.3AKB-6899
CAS :AKB-6899 is an inhibitor of prolyl hydroxylase domain 3 (PHD3) and increases the soluble form of the VEGF receptor (sVEGFR-1) production from GM-CSF-treatedFormule :C14H11FN2O4Degré de pureté :97.87%Couleur et forme :SolidMasse moléculaire :290.25TCJL37
CAS :TCJL37: potent, selective TYK2 inhibitor (K i 1.6 nM), oral, for IBD research.Formule :C17H11ClF2N4O2Couleur et forme :SolidMasse moléculaire :376.74BMS-599626 Hydrochloride
CAS :BMS-599626 HCl (AC480 HCl) is an oral inhibitor of HER1, HER2, HER4 kinases, potentially blocking tumor growth. IC50: 22/32/190 nM.Formule :C27H28ClFN8O3Degré de pureté :99.98%Couleur et forme :SolidMasse moléculaire :567.01EGFR/HER2-IN-11
CAS :EGFR/HER2-IN-11 (compound 20), an orally active dual inhibitor targeting human epidermal growth factor receptor 2 (HER2) and epidermal growth factor receptor (EGFR), demonstrates IC50 values of 7.7 nM and 22 nM, respectively. This compound shows strong antitumor efficacy, specifically inhibiting the proliferation of BT-474 cancer cells with a GI50 of 601 nM [1].Formule :C23H21ClF3N5O2Couleur et forme :SolidMasse moléculaire :491.89BPR1J-340
CAS :BPR1J-340, a novel potent FLT3 inhibitor, shows anticancer promise, with IC50 ~25 nM and GC50 ~5 nM, causing apoptosis in AML cells.Formule :C29H34N8O3Couleur et forme :SolidMasse moléculaire :542.63FGFR4-IN-8
CAS :FGFR4-IN-8 is a selective, ATP-competitive FGFR4 inhibitor with IC50s as low as 0.25 nM, halting growth of Hep3B cells at 29 nM and showing in vivo efficacy.Formule :C32H34Cl2FN7O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :654.56Brolucizumab
CAS :Brolucizumab (anti-VEGF-A scFv) potently blocks VEGF-A to reduce neovascularization in wet AMD, with picomolar binding affinity.Degré de pureté :95%Couleur et forme :LiquidMasse moléculaire :~150 kDa10Z-Hymenialdisine
CAS :Pan kinase inhibitorFormule :C11H10BrN5O2Degré de pureté :98%Couleur et forme :Light Yellow SolidMasse moléculaire :324.13Henatinib
CAS :Henatinib: orally active multi-kinase inhibitor targeting VEGFR-2, c-kit, PDGFR with antitumor effects.Formule :C25H29FN4O4Couleur et forme :SolidMasse moléculaire :468.52Risvodetinib
CAS :Risvodetinib: potent inhibitor of protein tyrosine kinases c-Abl1, c-Abl2, and c-kit.Formule :C33H34N8O2Couleur et forme :SolidMasse moléculaire :574.68EGFR kinase inhibitor 1
CAS :Potent EGFR blocker; acts on WT, L858R/T790M (IC50: 1.7 nM), less on T790M/C797S; stalls cell cycle, induces apoptosis, deters metastasis.Formule :C30H31N7O2Couleur et forme :SolidMasse moléculaire :521.61JAK-IN-26
CAS :JAK-IN-26 (compound 2) is an orally active inhibitor of the Janus kinase (JAK) enzyme with favorable pharmacokinetic properties, exhibiting potency inFormule :C22H24N6O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :420.46FGFR-IN-2
CAS :FGFR-IN-2 (compound 1) is a potent inhibitor of FGFR, acting on FGFR1 (IC50: 7.3 nM), FGFR2 (IC50: 4.3 nM), FGFR3 (IC50: 7.6 nM) and FGFR4 (IC50: 11 nM).Formule :C25H30N6O2Couleur et forme :SolidMasse moléculaire :446.54EGFR-IN-30
CAS :EGFR-IN-30 is an EGFR inhibitor (IC50: 1-10 nM, <1 nM WT/mutants) with potential in cancer research.Formule :C28H33BrN7O2PCouleur et forme :SolidMasse moléculaire :610.49FLT3/ITD-IN-4
CAS :FLT3/ITD-IN-4 inhibits FLT3-ITD mutations in acute myeloid leukemia (IC50: 2.3 nM).Formule :C25H22N4O5Couleur et forme :SolidMasse moléculaire :458.47Atiprimod dimaleate
CAS :Atiprimod Dimaleate is a JAK2 inhibitor.Formule :C30H52N2O8Couleur et forme :SolidMasse moléculaire :568.74DW10075
CAS :DW10075, a novel potent and highly selective inhibitor of VEGFR, exhibits antitumor activities both in vitro and in vivo.Formule :C29H23N5O3Couleur et forme :SolidMasse moléculaire :489.52EGFR-IN-74
EGFR-IN-74 is a potent inhibitor targeting EGFR, specifically effective against the L858R/T790M mutations, exhibiting an IC50 value of 138 nM.Formule :C32H28BrF3N6O4SCouleur et forme :SolidMasse moléculaire :729.57Lepzacitinib
CAS :Lepzacitinib is a selective, inflammatory, small molecule JAK1/3(Janus kinase) inhibitor primarily used for the treatment of atopic dermatitis.Formule :C18H21N5O3Degré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :355.39Ref: TM-T78207
1mg50,00€5mg104,00€1mL*10mM (DMSO)114,00€10mg167,00€25mg340,00€50mg505,00€100mg712,00€200mg1.009,00€BT424
CAS :BT424, a specific HCK inhibitor, modulates macrophage activation and autophagy in vitro, and mitigates inflammation and renal fibrosis in the UUO model [1].Formule :C22H15BCl2N2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :421.08DosatiLink-1
CAS :DosatiLink-1 acts as an inhibitor of the Abelson murine leukemia (ABL) enzyme [1].Formule :C69H93Cl2F2N13O17SCouleur et forme :SolidMasse moléculaire :1517.52Upadacitinib tartrate
CAS :Upadacitinib: potent, selective JAK1 inhibitor, 74x preferential to JAK2, effective in rat arthritis.Formule :C21H33F3N6O11Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :602.521TIE-2/VEGFR-2 kinase-IN-5
CAS :TIE-2/VEGFR-2 kinase-IN-5 is a TIE-2 and VEGFR-2 tyrosine kinase receptor inhibitor commonly used in biomedical research related to angiogenesis.Formule :C21H13F6N5O2Degré de pureté :99.79%Couleur et forme :SolidMasse moléculaire :481.35Labuxtinib
CAS :Labutinib is a selective inhibitor of the c-kit tyrosine kinase [1].Formule :C20H16FN5O2Degré de pureté :99.95%Couleur et forme :SolidMasse moléculaire :377.37Ref: TM-T79851
1mg132,00€5mg319,00€1mL*10mM (DMSO)354,00€10mg512,00€25mg1.018,00€50mg1.468,00€100mg1.972,00€200mg2.655,00€DZD1516
CAS :DZD1516, a potent and selective HER2 inhibitor (IC50 = 0.56 nM), demonstrates good blood-brain barrier permeability and exhibits antitumor activity in bothFormule :C28H27F2N7O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :547.56PI3K/VEGFR2-IN-1
CAS :PI3K/VEGFR2-IN-1 is a potent dual inhibitor targeting both PI3K and VEGFR2 with IC50 values of 2.21 μM for PI3K and 68 μM for VEGFR2, respectively.Formule :C17H14ClN3OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :343.83BGB-8035
CAS :BGB-8035 is a BTK inhibitor with antitumor activity that inhibits BTK, TEC, and EGFR.BGB-8035 is used in the study of tumors and autoimmune diseases.Formule :C24H31N5O4Degré de pureté :96.74%Couleur et forme :SolidMasse moléculaire :453.53ALK-IN-27
CAS :Neladalkib (NVL-655) is an ALK inhibitor with antitumor activity for the study of non-small cell cancers.Formule :C23H22ClFN6ODegré de pureté :99.71%Couleur et forme :SolidMasse moléculaire :452.91HIF-2α agonist 2
CAS :HIF-2α agonist 2 is an HIF-2α agonist with an EC50 value of 1.68 μM for HIF-2α.Formule :C13H8Br2N2O2SDegré de pureté :98.87%Couleur et forme :SoildMasse moléculaire :416.09EGFR/ErbB-2 inhibitor-1
CAS :EGFR/ErbB-2 inhibitor-1 is a selective ErbB2/HER2 inhibitor that effectively blocks ErbB2 and HER2 signaling.Formule :C23H15ClFN3OS2Degré de pureté :98.93%Couleur et forme :SolidMasse moléculaire :467.97EGFR-IN-1 hydrochloride
CAS :EGFR-IN-1 HCl targets L858R/T790M EGFR mutants over wild-type; IC50: 4 nM in H1975, 28 nM in mutant HCC827 cells.Formule :C28H31ClN6O4Degré de pureté :99.16%Couleur et forme :SolidMasse moléculaire :551.04Ref: TM-T11157L
1mg62,00€5mg142,00€1mL*10mM (DMSO)190,00€10mg205,00€25mg319,00€50mg429,00€100mg587,00€200mg795,00€IN-1130
CAS :IN-1130: ALK5 inhibitor, IC50 - 5.3 nM (Smad3), 36 nM (casein), 4.3 μM (p38α MAPK).Formule :C25H20N6ODegré de pureté :99.79%Couleur et forme :SolidMasse moléculaire :420.47Ifebemtinib
CAS :Ifebemtinib (BI-853520) is an adhesion plaque kinase inhibitor with anti-tumour activity for the study of breast cancer.Formule :C28H28F4N6O4Degré de pureté :98.84% - 99.85%Couleur et forme :SolidMasse moléculaire :588.55Ref: TM-T64167
1mg146,00€5mg245,00€1mL*10mM (DMSO)316,00€10mg369,00€25mg572,00€50mg882,00€100mg1.243,00€JAK-IN-3
CAS :JAK-IN-3 is a potent JAK inhibitor that inhibits JAK3, JAK1, TYK2, and JAK2, and can be used for the study of immune system disorders.Formule :C18H20N4O3Degré de pureté :98.04% - 98.19%Couleur et forme :SolidMasse moléculaire :340.38Ref: TM-T11704
1mg126,00€2mg178,00€5mg304,00€1mL*10mM (DMSO)334,00€10mg492,00€25mg982,00€50mg1.558,00€100mg2.538,00€200mg3.402,00€FIIN-1
CAS :FIIN-1 (FGFR irreversible inhibitor-1) is an irreversible and selective FGFR inhibitor with Kd of 2.8, 6.9, 5.4, 120, 32 and 120 nM for FGFR1, FGFR2, FGFR3,Formule :C32H39Cl2N7O4Degré de pureté :98.75%Couleur et forme :SolidMasse moléculaire :656.6Ref: TM-T37426
1mg74,00€2mg98,00€5mg192,00€10mg313,00€25mg520,00€50mg742,00€100mg982,00€500mg2.008,00€Sevabertinib
CAS :Sevabertinib (BAY 2927088) is an EGFR tyrosine kinase inhibitor, with anticancer activity, used in research on non-small cell lung cancer.Formule :C24H25ClN4O5Degré de pureté :99.81%Couleur et forme :SolidMasse moléculaire :484.93Zongertinib
CAS :Zongertinib is a human HER2-selective tyrosine kinase inhibitor, a novel TK that is highly selective for covalent binding to the HER2 tyrosine kinase domain (Formule :C29H29N9O2Degré de pureté :98.24%Couleur et forme :SolidMasse moléculaire :535.6Ref: TM-T69534
1mg66,00€5mg145,00€1mL*10mM (DMSO)170,00€10mg222,00€25mg371,00€50mg522,00€100mg708,00€TAK-020
CAS :TAK-020 is a potent covalent inhibitor of Btk with potential antitumor activity for the study of rheumatoid arthritis and immune-related diseases.Formule :C18H17N5O3Degré de pureté :98.66%Couleur et forme :SolidMasse moléculaire :351.36Ref: TM-T9529
1mg138,00€5mg334,00€1mL*10mM (DMSO)358,00€10mg597,00€25mg1.234,00€50mg1.908,00€100mg2.952,00€WAY-600
CAS :WAY-600 is a potent, ATP-competitive and selective inhibitor of mTOR with IC50 of 9 nM; blocks mTORC1/P-S6K(T389) and mTORC2/P-AKT(S473) but not P-AKT(T308).Formule :C28H30N8ODegré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :494.59Ref: TM-T6730
500mgÀ demander1mg35,00€2mg60,00€5mg92,00€1mL*10mM (DMSO)105,00€10mg133,00€25mg233,00€50mg344,00€100mg480,00€BMS-935177
CAS :BMS-935177 is a reversible BTK inhibitor with IC50 value of 3 nM.Formule :C31H26N4O3Degré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :502.56KER047
CAS :ALK2-IN-4, a highly effective ALK2 inhibitor.Formule :C26H30FN7ODegré de pureté :98.49% - >99.99%Couleur et forme :SolidMasse moléculaire :475.56Ref: TM-T39764
1mg90,00€5mg215,00€1mL*10mM (DMSO)236,00€10mg349,00€25mg713,00€50mg1.018,00€100mg1.558,00€EGFR-IN-87
CAS :EGFR-IN-87 is an EGFR tyrosine kinase inhibitor with potent inhibitory activity, exhibiting IC50 values of 3.1 nM, 1.3 nM, and 7.1 nM against EGFR_d746-750,Formule :C28H33N7O2Degré de pureté :98.64%Couleur et forme :SolidMasse moléculaire :499.61CH6953755
CAS :CH6953755: oral YES1 kinase inhibitor, IC50 1.8 nM, potent, selective, anticancer, halts cell proliferation.Formule :C26H22F2N6O4SDegré de pureté :98.87%Couleur et forme :SolidMasse moléculaire :552.55Ref: TM-T10784
1mg55,00€5mg116,00€1mL*10mM (DMSO)141,00€10mg177,00€25mg348,00€50mg557,00€100mg893,00€HM43239
CAS :HM43239: oral FLT3 inhibitor; IC50: FLT3 WT 1.1nM, ITD 1.8nM, D835Y 1.0nM; blocks p-STAT5/p-ERK; affects SYK, JAK1/2, TAK1; halts leukemia cell growth.Formule :C29H33ClN6Degré de pureté :99.7%Couleur et forme :SolidMasse moléculaire :501.07Ref: TM-T9428
1mg50,00€5mg99,00€1mL*10mM (DMSO)109,00€10mg158,00€25mg309,00€50mg464,00€100mg647,00€200mg855,00€Src Inhibitor 3
CAS :Src Inhibitor 3 blocks c-Src kinase (IC50 <3 nM CSK HTRF, <4 nM Caliper), boosting T cell growth from receptor signals.Formule :C34H32ClFN8O4Degré de pureté :98.35%Couleur et forme :SolidMasse moléculaire :671.12Ref: TM-T13000
100mgÀ demander1mg96,00€5mg177,00€1mL*10mM (DMSO)264,00€10mg304,00€25mg480,00€50mg665,00€CAY10781
CAS :CAY10781 inhibits NRP-1/VEGF-A binding by 43% at 12.5μM and blocks VEGFR2 phosphorylation in CAD cells.Formule :C11H9N3O3Degré de pureté :99.49%Couleur et forme :SolidMasse moléculaire :231.21Ref: TM-T37424
2mg39,00€5mg54,00€10mg77,00€1mL*10mM (DMSO)79,00€25mg124,00€50mg172,00€100mg316,00€200mg442,00€EGFR-IN-8
CAS :EGFR-IN-8, a dual inhibitor targeting both EGFR and c-Met, shows potential as a promising candidate for further development in treating EGFR TKI-resistant NSCLCFormule :C32H23ClF3N7O4Degré de pureté :99.51%Couleur et forme :SolidMasse moléculaire :662.02EGFR/HER2-IN-4
EGFR/HER2-IN-4: oral, irreversible dual EGFR inhibitor (IC50: 0.6 nM), targets L858R/T790M mutations, potent anti-lung cancer effects in vivo.Couleur et forme :SolidProtein kinase inhibitor 11
CAS :Protein kinase inhibitor 11 (Compound I-96) is an agent that inhibits the activity of PIM-1, CDK-2, GSK-3, and SRC. It shows potential for research in cancer, autoimmune diseases, and neurodegenerative disorders.Formule :C21H18FN5O2SCouleur et forme :SolidMasse moléculaire :423.463AKN-028 acetate
AKN-028 acetate: an oral TK inhibitor for AML research, targets FLT3 with IC50 of 6 nM, inhibits autophosphorylation, and induces apoptosis.Formule :C19H18N6O2Couleur et forme :SolidMasse moléculaire :362.39VEGFR-2-IN-18
VEGFR-2-IN-18 is a potent VEGFR-2 inhibitor with a 60 nM IC50, promoting cell apoptosis and anticancer effects.Formule :C20H13ClN4O2Couleur et forme :SolidMasse moléculaire :376.8EGFR/HER2/DHFR-IN-1
Potent EGFR/HER2/DHFR inhibitor for MCF-7 breast cancer; IC50: 0.153/0.108/0.291 μM; arrests G1/S phase, triggers apoptosis.Formule :C14H11BrN4O2SCouleur et forme :SolidMasse moléculaire :379.23CEE321
CAS :CEE321 is an effective pan-JAK inhibitor with an IC50 of 54 nM. It effectively inhibits biomarkers associated with atopic dermatitis.Formule :C18H16ClN5OCouleur et forme :SolidMasse moléculaire :353.806EGFR-IN-47
EGFR-IN-47: strong oral EGFRL858R/T790M/C797S blocker, induces cell death; promising for NSCLC research. IC50: 0.01 μM.Formule :C29H35N7Couleur et forme :SolidMasse moléculaire :481.64FGFR4-IN-9
FGFR4-IN-9 is a selective inhibitor of FGFR4 (IC50: 75.3 nM) that effectively inhibits the growth and angiogenesis of hepatocellular carcinoma cells.Formule :C24H22ClF3N4O4Couleur et forme :SolidMasse moléculaire :522.9RGB-286638
CAS :RGB-286638 inhibits multiple CDKs and GSK-3β, TAK1, Jak2, MEK1 with IC50s as low as 1-54 nM.Formule :C29H37Cl2N7O4Couleur et forme :SolidMasse moléculaire :618.55FGFR1 inhibitor-15
CAS :FGFR1inhibitor-15 (Compound 23) is an FGFR1 inhibitor with an IC50 value of 27 μM, useful for tumor research.Formule :C17H13FN4OCouleur et forme :SolidMasse moléculaire :308.31Clifutinib
CAS :Clifutinib (Compound 9e) is an orally active, selective inhibitor of FMS-like tyrosine kinase 3 (FLT3-ITD) with an IC50 of 15.1 nM. It inhibits FLT3-ITD kinase activity and blocks downstream signaling pathways, including RAS/MAPK, PI3K/AKT, and JAK/STAT5. Clifutinib induces apoptosis in FLT3-ITD mutated acute myeloid leukemia (AML) cells and is a potential candidate for research in relapsed/refractory FLT3-ITD positive AML.
Formule :C29H34N4O4Couleur et forme :SolidMasse moléculaire :502.605EGFR-IN-149
CAS :EGFR-IN-149 (Compound 3-OH) is an EGFR inhibitor with an IC50 value of 0.42 nM.Formule :C16H15N3OSCouleur et forme :SolidMasse moléculaire :297.375W23-1006
CAS :W23-1006 is a selective covalent ALKBH5 inhibitor. It binds to the ALKBH5 C200 residue with an IC50 value of 3.848 μM. The inhibitory activity of W23-1006 is approximately 30 times stronger than that of FTO and 8 times greater than that of ALKBH3. W23-1006 is applicable for research in triple-negative breast cancer (TNBC).Formule :C17H12BrN3O5Couleur et forme :SolidMasse moléculaire :418.198Tofacitinib Prodrug-1
Tofacitinib Prodrug-1: an oral prodrug reducing Tofacitinib's side effects, treats ulcerative colitis in mice effectively with low toxicity.Formule :C36H39ClN10O7Couleur et forme :SolidMasse moléculaire :759.21Gamendazole
CAS :Gamendazole is a novel drug candidate for male contraception. It has been shown to reduce fertility in male rats without affecting testosterone levels.Formule :C18H11Cl2F3N2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :415.19JAK-2/3-IN-3
JAK-2-/3-IN-3 (ST4j) is a potent JAK2/3 inhibitor for leukemia research, with IC50s: JAK2, 13 nM; JAK3, 14.86 nM; induces apoptosis.Formule :C13H10Cl2N4O2Couleur et forme :SolidMasse moléculaire :325.15GLPG3312
CAS :GLPG3312 is a selective and potent pan-SIK inhibitor with the advantage of oral activity, for SIK1, SIK2 and SIK3, anti-inflammatory and immunomodulatory .Formule :C23H21F2N5O3Degré de pureté :98.53%Couleur et forme :SolidMasse moléculaire :453.44EGFR-IN-159
CAS :EGFR-IN-159 (compound 12) is a dihydropyrimidine and a potent EGFR inhibitor with an IC50 of 29.00 nM. It exhibits dose-dependent inhibition of EGFR and HER2. The compound shows cytotoxicity against MCF-7 breast cancer cells and Vero cells with IC50 values of 16.07 μg/mL and 35.98 μg/mL, respectively. EGFR-IN-159 does not cross the blood-brain barrier (BBB) and demonstrates significant anticancer activity.Formule :C21H23N3O5Couleur et forme :SolidMasse moléculaire :397.424MM-589 TFA
CAS :MM-589 TFA is a potent WD repeat domain 5 (WDR5)inhibitor and mixed lineage leukemia (MLL) protein-protein interaction.Formule :C30H45F3N8O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :686.72HER2-IN-12
HER2-IN-12 is an HER2 inhibitor with an IC50 value of 121 nM and can be used to study cancers such as breast cancer.Formule :C17H18BrN5O2SCouleur et forme :SolidMasse moléculaire :436.33
