Angiogenèse
Les inhibiteurs de l'angiogenèse sont des composés qui interfèrent avec la formation de nouveaux vaisseaux sanguins, un processus crucial dans la croissance et la métastase des cancers. En inhibant l'angiogenèse, ces composés peuvent restreindre l'apport sanguin aux tumeurs, ralentissant ou arrêtant leur croissance. Les inhibiteurs de l'angiogenèse sont essentiels dans la recherche sur le cancer et le développement thérapeutique, offrant des informations sur les mécanismes de progression tumorale et proposant des traitements potentiels pour le cancer et d'autres maladies liées à l'angiogenèse. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de l'angiogenèse de haute qualité pour soutenir vos recherches en oncologie et biologie vasculaire.
Sous-catégories appartenant à la catégorie "Angiogenèse"
- BTK(167 produits)
- Bcr-Abl(118 produits)
- EGFR(587 produits)
- FAK(72 produits)
- FLT(86 produits)
- Récepteur du facteur de croissance des fibroblastes (FGFR)(180 produits)
- JAK(243 produits)
- PDGFR(129 produits)
- RAAS(89 produits)
- Src(82 produits)
- Syk(37 produits)
- Thrombine(58 produits)
- VDA(2 produits)
- VEGFR(244 produits)
Affichez 6 plus de sous-catégories
2400 produits trouvés pour "Angiogenèse"
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GDC-0214
CAS :GDC-0214 is an inhaled small-molecule JAK1 inhibitor and reduces fractional exhaled nitric oxide (Feno).Formule :C28H28ClF2N9O3Degré de pureté :99.75%Couleur et forme :SolidMasse moléculaire :612.03Ref: TM-T9826
1mg93,00€5mg182,00€1mL*10mM (DMSO)245,00€10mg269,00€25mg429,00€50mg610,00€100mg820,00€200mg1.099,00€SU14813
CAS :SU14813: inhibits multiple kinases (VEGFR2, VEGFR1, PDGFRβ, KIT) with IC50s of 50, 2, 4, 15 nM; antiangiogenic and antitumor.Formule :C23H27FN4O4Degré de pureté :98.13%Couleur et forme :SolidMasse moléculaire :442.48PD-161570
CAS :PD-161570 is a potent and ATP-competitive human FGF-1 receptor inhibitor with an IC50 of 39.9 nM and a Ki of 42 nM.Formule :C26H35Cl2N7ODegré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :532.51Ref: TM-T23127
1mg34,00€5mg96,00€1mL*10mM (DMSO)118,00€10mg141,00€25mg289,00€50mg465,00€100mg662,00€200mg888,00€Crizotinib
CAS :Crizotinib (PF-02341066) is an ATP-competitive small-molecule tyrosine kinases inhibitor of c-MET (IC50: 8 nM) and ALK (IC50: 20 nM) receptor.Formule :C21H22Cl2FN5ODegré de pureté :99% - 99.87%Couleur et forme :SolidMasse moléculaire :450.34Ref: TM-T1661
2mgÀ demander5mg33,00€10mg49,00€1mL*10mM (DMSO)50,00€25mg55,00€50mg64,00€100mg88,00€500mg147,00€Gandotinib
CAS :LY2784544(Gandotinib (LY2784544)) is a potent JAK2 inhibitor (IC50: 3 nM), effective in JAK2V617F(Ki: 0.245 nM).Formule :C23H25ClFN7ODegré de pureté :99.33% - 99.86%Couleur et forme :SolidMasse moléculaire :469.94NVP-BSK805 trihydrochloride
CAS :NVP-BSK805 trihydrochloride inhibits JAK2 (0.48 nM IC50); also affects JAK1, JAK3, TYK2.Formule :C27H31Cl3F2N6OCouleur et forme :SolidMasse moléculaire :599.93MLN8054
CAS :MLN8054 is a potent and selective Aurora A kinase inhibitor with an IC50 of 4 nM.Formule :C25H15ClF2N4O2Degré de pureté :98.07% - 98.26%Couleur et forme :SolidMasse moléculaire :476.86Ref: TM-T6315
1mg50,00€2mg67,00€5mg84,00€1mL*10mM (DMSO)88,00€10mg120,00€25mg220,00€50mg356,00€100mg537,00€Zorifertinib
CAS :Zorifertinib (AZD3759) is an orally active, effective and central nervous system-penetrant EGFR inhibitor.Formule :C22H23ClFN5O3Degré de pureté :98.20% - 99.36%Couleur et forme :White To Off-White SolidMasse moléculaire :459.9Ibrutinib
CAS :Ibrutinib (PCI-32765) is an irreversible inhibitor of BTK (IC50: 0.5 nM) that selectively blocks B cell activation.Formule :C25H24N6O2Degré de pureté :98% - 99.95%Couleur et forme :SolidMasse moléculaire :440.50BGG463
CAS :BGG463 (K 0859) can inhibit c-ABL-T334I, BCR-ABL and BCR-ABL-T315I variants with an IC50 of 0.25 μM, 0.09 μM and 0.590 μM, respectively.Formule :C30H29F3N6O3Degré de pureté :98.21% - >99.99%Couleur et forme :SolidMasse moléculaire :578.58Ref: TM-T4618
1mg58,00€2mg82,00€5mg113,00€1mL*10mM (DMSO)145,00€10mg178,00€25mg333,00€50mg477,00€100mg692,00€SKLB4771
CAS :SKLB4771 (FLT3-IN-1) is a novel potent and selective Flt3 inhibitor.Formule :C25H27N7O3S2Degré de pureté :98% - >99.99%Couleur et forme :SolidMasse moléculaire :537.66Ref: TM-T2051
1mg63,00€2mg93,00€5mg124,00€1mL*10mM (DMSO)148,00€10mg177,00€25mg371,00€50mg557,00€100mg792,00€500mg1.611,00€WS6
CAS :WS6, a β cell proliferation inducer, regulates Erb3 binding protein-1 (EBP1) and the IκB kinase pathway.Formule :C29H31F3N6O3Degré de pureté :97.65% - 99.95%Couleur et forme :SolidMasse moléculaire :568.59Agerafenib
CAS :Agerafenib (CEP32496) is a highly potent inhibitor of BRAF.Formule :C24H22F3N5O5Degré de pureté :95.78% - 99.23%Couleur et forme :SolidMasse moléculaire :517.46Ref: TM-T2070
1mg39,00€1mL*10mM (DMSO)90,00€5mg93,00€10mg124,00€25mg219,00€50mg358,00€100mg530,00€200mg757,00€(Z)-SU4312
CAS :(Z)-SU4312 is a inhibitor of MAO-B and NOS(IC50 value of 0.2 μM, 19.0μM,respectively).Formule :C17H16N2ODegré de pureté :99.17%Couleur et forme :SolidMasse moléculaire :264.32Ref: TM-T5676
1mg58,00€1mL*10mM (DMSO)111,00€5mg116,00€10mg172,00€25mg281,00€50mg396,00€100mg525,00€200mg705,00€4-(6,7-dimethoxyquinolin-4-yl)oxyaniline
CAS :4-(6,7-dimethoxyquinolin-4-yl)oxyaniline is a quinoline used in creating drugs and pesticides.Formule :C17H16N2O3Degré de pureté :99.93%Couleur et forme :SolidMasse moléculaire :296.32ZM39923 hydrochloride
CAS :ZM39923 hydrochloride (JAK3 Inhibitor IV) is an JAK1/3 inhibitor, almost no activity to JAK2 and modestly potent to EGFR; also is sensitive to transglutaminase.Formule :C23H25NO·HClDegré de pureté :98.05%Couleur et forme :SolidMasse moléculaire :367.91Ritlecitinib
CAS :Ritlecitinib (PF-06651600) is an orally available, selective JAK3 inhibitor and does not affect the activity of JAK1/2.Cost-effective and quality-assured.Formule :C15H19N5ODegré de pureté :98.82% - 99.92%Couleur et forme :SolidMasse moléculaire :285.34Ref: TM-T5382
2mg37,00€5mg52,00€1mL*10mM (DMSO)73,00€10mg90,00€25mg205,00€50mg290,00€100mg408,00€200mg595,00€AMG 925
CAS :AMG 925 is a potent and orally bioavailable dual FLT3/CDK4 inhibitor with IC50 of 1 nM and 3 nM, respectively.Formule :C26H29N7O2Degré de pureté :99.75%Couleur et forme :SolidMasse moléculaire :471.55SU 4313
CAS :SU 4313 is a bioactive chemical.Formule :C18H17NODegré de pureté :99.51% - 99.89%Couleur et forme :SolidMasse moléculaire :263.33Ref: TM-T3568
1mg34,00€5mg66,00€1mL*10mM (DMSO)73,00€10mg92,00€25mg167,00€50mg236,00€100mg353,00€200mg517,00€Tofacitinib
CAS :Tofacitinib (Tasocitinib) is an orally Janus kinase inhibitor. Tofacitinib is used for the treatment of rheumatoid arthritis. Cost effective and quality assured.Formule :C16H20N6ODegré de pureté :99% - >99.99%Couleur et forme :SolidMasse moléculaire :312.37PF-6274484
CAS :PF-6274484 is an EGFR inhibitor with Ki values of 0.14 and 0.18 nM for EGFR-L858R/T790M and WT-EGFR, respectively.Formule :C18H14ClFN4O2Degré de pureté :97.71%Couleur et forme :SolidMasse moléculaire :372.78Ref: TM-T22396
2mg38,00€5mg57,00€1mL*10mM (DMSO)63,00€10mg96,00€25mg177,00€50mg333,00€100mg495,00€500mg1.071,00€AD80
CAS :AD80, a multikinase inhibitor, inhibits RET, RAF, SRCand S6K, with greatly reduced mTOR activity.Formule :C22H19F4N7ODegré de pureté :99.49% - 99.75%Couleur et forme :SolidMasse moléculaire :473.43Ref: TM-T4301
1mg44,00€1mL*10mM (DMSO)90,00€5mg96,00€10mg138,00€25mg268,00€50mg439,00€100mg645,00€500mg1.333,00€Canertinib
CAS :Canertinib (CI-1033), a pan-erbB inhibitor, effectively targets esophageal cancer in vitro/vivo, altering metabolism and reducing growth and hypoxia.Formule :C24H25ClFN5O3Degré de pureté :98% - >99.99%Couleur et forme :White Or Similar To White Crystalline PowderMasse moléculaire :485.94WH-4-023
CAS :WH-4-023 (Dual LCK/SRC inhibitor) is a potent and orally active Lck/Src inhibitor. It also potently inhibits SIK.Formule :C32H36N6O4Degré de pureté :98% - 99.75%Couleur et forme :SolidMasse moléculaire :568.67eCF506
CAS :eCF506 is a potent and selective inhibitor of SRC (IC50 < 0.5 nM)Formule :C26H38N8O3Degré de pureté :97.85% - 98.16%Couleur et forme :SolidMasse moléculaire :510.63Pelitinib
CAS :Pelitinib (EKB-569) (EKB-569) is an effective irreversible EGFR inhibitor (IC50: 38.5 nM).Formule :C24H23ClFN5O2Degré de pureté :98.37% - 99.84%Couleur et forme :Off-White SolidMasse moléculaire :467.92E-4031 dihydrochloride
CAS :E-4031 dihydrochloride is a methanesulfonanilide class III antiarrhythmic agent that prolongs cardiac action potential duration by blocking ERG K+ channels (IC50 = 29 nM)Formule :C21H29Cl2N3O3SDegré de pureté :99.31% - 99.87%Couleur et forme :SolidMasse moléculaire :474.44PF-06651600 malonate
CAS :PF-06651600 is a potent and selective JAK3 inhibitor.Formule :C18H23N5O5Couleur et forme :SolidMasse moléculaire :389.41WZ4002
CAS :WZ4002 is a mutant-selective EGFR inhibitor for EGFR(L858R) and EGFR(T790M) with IC50 of 2 nM/8 nM.Formule :C25H27ClN6O3Degré de pureté :97.51%Couleur et forme :SolidMasse moléculaire :494.97Ref: TM-T6238
2mg34,00€5mg49,00€1mL*10mM (DMSO)50,00€10mg70,00€25mg111,00€50mg177,00€100mg313,00€200mg464,00€EBE-A22
CAS :EBE-A22 (PD153035 Analog 63) is a derivative of PD 153035 which can inhibit ErbB-1-phosphorylation, whereas EBE-A22 is inactive.Formule :C17H16BrN3O2Degré de pureté :99.087% - 99.88%Couleur et forme :SolidMasse moléculaire :374.23Vactosertib Hydrochloride
CAS :Vactosertib Hydrochloride (EW-7197 Hydrochloride) is an ALK5 inhibitor, a TGF-β receptor I inhibitor with antimetastatic and anticancer effects.Formule :C22H19ClFN7Degré de pureté :98.03%Couleur et forme :SolidMasse moléculaire :435.89Ref: TM-T15262
1mg34,00€5mg66,00€1mL*10mM (DMSO)73,00€10mg92,00€25mg152,00€50mg230,00€100mg356,00€200mg522,00€RepSox
CAS :RepSox (ALK5 Inhibitor II) is a TGFβR-1/ALK5 inhibitor that selectively inhibits the binding of ATP to ALK5 and the autophosphorylation of ALK5 (IC50=23/4 nM).Formule :C17H13N5Degré de pureté :98.8% - 99.73%Couleur et forme :SolidMasse moléculaire :287.32Ref: TM-T6337
1mg34,00€2mg46,00€5mg63,00€1mL*10mM (DMSO)69,00€10mg80,00€25mg116,00€50mg169,00€100mg241,00€500mg597,00€hVEGF-IN-1
CAS :hVEGF-IN-1 inhibits human VEGF-A translation and has antitumor activity.Formule :C34H43N7O2Degré de pureté :99.76% - >99.99%Couleur et forme :SolidMasse moléculaire :581.75NS309
CAS :NS309 activates SK/KCa2, IK/KCa3.1 (0.12-1.2 μM EC50, 10-90 nM EC50), and Kv11.1 channels; doesn't affect BK/KCa1.1; modulates neuronal firing.Formule :C8H4Cl2N2O2Degré de pureté :97.55%Couleur et forme :SolidMasse moléculaire :231.04Ref: TM-T4612
5mg54,00€1mL*10mM (DMSO)59,00€10mg65,00€25mg113,00€50mg205,00€100mg305,00€200mg445,00€500mg712,00€CHMFL-BMX-078
CAS :CHMFL-BMX-078 is a highly potent and selective type II irreversible BMX kinase inhibitor with an IC50 of 11 nM.Formule :C33H35N7O6Degré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :625.67Olafertinib
CAS :Olafertinib (RX-518) is a novel mutant-selective, irreversible, orally available EGFR inhibitor. It can overcome T790M-mediated resistance in NSCLC.Formule :C29H28F2N6O2Degré de pureté :98.62% - 99.706%Couleur et forme :SolidMasse moléculaire :530.57RAF265
CAS :RAF265 (CHIR-265) inhibits C-Raf/B-Raf/V600E (IC50: 3-60 nM), blocks VEGFR2 (EC50: 30 nM), in Phase 2 trials.Formule :C24H16F6N6ODegré de pureté :99.56%Couleur et forme :SolidMasse moléculaire :518.41Ref: TM-T6296
1mg44,00€2mg59,00€5mg93,00€1mL*10mM (DMSO)94,00€10mg140,00€25mg253,00€50mg413,00€100mg605,00€Lorlatinib
CAS :Lorlatinib (PF-6463922) is an orally available, ATP-competitive inhibitor of the receptor tyrosine kinases, anaplastic lymphoma kinase (ALK) and C-ros oncogeneFormule :C21H19FN6O2Degré de pureté :99.77% - 99.95%Couleur et forme :SolidMasse moléculaire :406.41Ref: TM-T3061
1mg34,00€2mg42,00€5mg60,00€1mL*10mM (DMSO)66,00€10mg89,00€25mg137,00€50mg212,00€100mg374,00€Seralutinib
CAS :Seralutinib (GB002) is an inhibitor of inhaled PDGFRα and PDGFRβ. It is used in the study for pulmonary arterial hypertension.Formule :C27H27N5O3Degré de pureté :99.09%Couleur et forme :SolidMasse moléculaire :469.54Ref: TM-T8900
1mg47,00€2mg62,00€5mg92,00€1mL*10mM (DMSO)92,00€10mg137,00€25mg236,00€50mg313,00€100mg497,00€GW786034B
CAS :Pazopanib HCl (Votrient) inhibits VEGFR1-3, PDGFR, FGFR, c-Kit, c-Fms with IC50 range 10-146 nM in cell-free assays.Formule :C21H23N7O2S·HClDegré de pureté :99.87%Couleur et forme :SolidMasse moléculaire :473.98WS3
CAS :WS3, a β cell proliferation inducer, regulates Erb3 binding protein-1 (EBP1) and the IκB kinase pathway.Formule :C28H30F3N7O3Degré de pureté :97.93% - 99.94%Couleur et forme :SolidMasse moléculaire :569.58Afatinib
CAS :Afatinib (BIBW 2992) is an irreversible and orally EGFR family inhibitor that inhibits EGFR and HER2. Afatinib has antitumor activity. Cost effective and quality assured.Formule :C24H25ClFN5O3Degré de pureté :98.56% - 99.9%Couleur et forme :Off-White SolidMasse moléculaire :485.94Ref: TM-T21312
5mg34,00€10mg49,00€1mL*10mM (DMSO)50,00€25mg81,00€50mg109,00€100mg137,00€200mg168,00€500mg284,00€(Z)-Semaxinib
CAS :(Z)-Semaxinib (SU5416) is a potent and selective VEGFR(Flk-1/KDR) inhibitor (IC50: 1.23 μM), 20-fold more selective for VEGFR over PDGFRβ, no inhibition forFormule :C15H14N2ODegré de pureté :98.82% - ≥95%Couleur et forme :SolidMasse moléculaire :238.28Ref: TM-T2496
10mg35,00€1mL*10mM (DMSO)44,00€25mg52,00€50mg79,00€100mg111,00€200mg168,00€500mg330,00€EAI045
CAS :EAI045, an allosteric inhibitor, targets towards drug-resistant EGFR mutants but avoids the wild-type receptor.Formule :C19H14FN3O3SDegré de pureté :98.00% - 99.12%Couleur et forme :SolidMasse moléculaire :383.4Ilorasertib
CAS :Ilorasertib (ABT-348) inhibits Aurora kinases A/B/C & RET, PDGFRβ, Flt1 (IC50: 1-120 nM).Formule :C25H21FN6O2SDegré de pureté :96.17% - 97.49%Couleur et forme :SolidMasse moléculaire :488.54BAY 61-3606 HCl
CAS :BAY 61-3606 HCl: a reversible Syk inhibitor, halts mast cell degranulation, cytokines, and sensitizes MCF-7 cells to TRAIL-induced apoptosis.Formule :C20H19ClN6O3Couleur et forme :SolidMasse moléculaire :426.86PF 477736
CAS :PF 477736 (PF-736,PF-00477736) is a specifc, effective and ATP-competitive Chk1 inhibitor (Ki: 0.49 nM ) and also inhibits FGFR3, Aurora-A, VEGFR2, Flt3, Fms (Formule :C22H25N7O2Degré de pureté :97.58% - 99.94%Couleur et forme :SolidMasse moléculaire :419.48XL019
CAS :XL019 is a potent and selective JAK2 inhibitor with IC50 of 2.2 nM, 100 fold selectivity over JAK1.Formule :C25H28N6O2Degré de pureté :99.19%Couleur et forme :SolidMasse moléculaire :444.53Ref: TM-T3072
2mg43,00€5mg63,00€1mL*10mM (DMSO)78,00€10mg92,00€25mg150,00€50mg215,00€100mg321,00€200mg477,00€Fisogatinib
CAS :Fisogatinib (BLU-554) is a highly potent, selective, and orally active FGFR4 inhibitor.Cost-effective and quality-assured.Formule :C24H24Cl2N4O4Degré de pureté :99.27% - ≥95%Couleur et forme :SolidMasse moléculaire :503.38Ref: TM-T3456
1mg50,00€5mg114,00€1mL*10mM (DMSO)127,00€10mg167,00€25mg294,00€50mg444,00€100mg670,00€500mg1.341,00€S49076 HCl
CAS :S49076 HCl (S-49076 Hydrochloride) is an effective inhibitor of MET, AXL/MER, and FGFR1/2/3.Formule :C22H18ClN3O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :439.85
