Angiogenèse
Les inhibiteurs de l'angiogenèse sont des composés qui interfèrent avec la formation de nouveaux vaisseaux sanguins, un processus crucial dans la croissance et la métastase des cancers. En inhibant l'angiogenèse, ces composés peuvent restreindre l'apport sanguin aux tumeurs, ralentissant ou arrêtant leur croissance. Les inhibiteurs de l'angiogenèse sont essentiels dans la recherche sur le cancer et le développement thérapeutique, offrant des informations sur les mécanismes de progression tumorale et proposant des traitements potentiels pour le cancer et d'autres maladies liées à l'angiogenèse. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de l'angiogenèse de haute qualité pour soutenir vos recherches en oncologie et biologie vasculaire.
Sous-catégories appartenant à la catégorie "Angiogenèse"
- BTK(147 produits)
- Bcr-Abl(103 produits)
- EGFR(572 produits)
- FAK(71 produits)
- FLT(91 produits)
- Récepteur du facteur de croissance des fibroblastes (FGFR)(169 produits)
- JAK(246 produits)
- PDGFR(126 produits)
- RAAS(87 produits)
- Src(80 produits)
- Syk(37 produits)
- Thrombine(47 produits)
- VDA(2 produits)
- VEGFR(262 produits)
Affichez 6 plus de sous-catégories
1522 produits trouvés pour "Angiogenèse"
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BMS-599626 Hydrochloride
CAS :<p>BMS-599626 HCl (AC480 HCl) is an oral inhibitor of HER1, HER2, HER4 kinases, potentially blocking tumor growth. IC50: 22/32/190 nM.</p>Formule :C27H28ClFN8O3Degré de pureté :99.98%Couleur et forme :SolidMasse moléculaire :567.01Lepzacitinib
CAS :<p>Lepzacitinib is a selective, inflammatory, small molecule JAK1/3(Janus kinase) inhibitor primarily used for the treatment of atopic dermatitis.</p>Formule :C18H21N5O3Degré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :355.39Atiprimod dimaleate
CAS :Atiprimod Dimaleate is a JAK2 inhibitor.Formule :C30H52N2O8Couleur et forme :SolidMasse moléculaire :568.74DW10075
CAS :<p>DW10075, a novel potent and highly selective inhibitor of VEGFR, exhibits antitumor activities both in vitro and in vivo.</p>Formule :C29H23N5O3Couleur et forme :SolidMasse moléculaire :489.52Famitinib malate
CAS :<p>Famitinib malate (SHR1020) is a potent oral kinase inhibitor targeting c-kit, VEGFR-2, and PDGFRβ, with IC50s 2.3, 4.7, 6.6 nM, useful for cancer research.</p>Formule :C27H33FN4O7Couleur et forme :SolidMasse moléculaire :544.57TIE-2/VEGFR-2 kinase-IN-3
CAS :<p>TIE-2/VEGFR-2 kinase-IN-3, a benzimidazole derivative, serves as a potent inhibitor of the tyrosine kinase receptors TIE-2 and VEGFR-2, exhibiting IC50 values</p>Formule :C23H17F4N5O3SCouleur et forme :SolidMasse moléculaire :519.47BT424
CAS :BT424, a specific HCK inhibitor, modulates macrophage activation and autophagy in vitro, and mitigates inflammation and renal fibrosis in the UUO model [1].Formule :C22H15BCl2N2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :421.08UNC5293
CAS :<p>UNC5293: potent oral MERTK inhibitor, Ki=190 pM, IC50=0.9 nM; selective vs Axl/Tyro3/Flt3; good mouse PK; used in leukemia research.</p>Formule :C30H42N6O2Couleur et forme :SolidMasse moléculaire :518.69T338C Src-IN-1
CAS :T338C Src-IN-1 is a potent mutant-Src T338C inhibitor(T338C,IC50=111 nM relative to WT c-Src (10-fold increase)).Formule :C17H20N6O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :372.44Itacnosertib (hydrocholide)
CAS :<p>Itacnosertib hydrochloride acts as an inhibitor targeting JAK2, ACVR1 (ALK2), and ALK5 [1].</p>Formule :C26H29ClN8OCouleur et forme :SolidMasse moléculaire :505.01FM-479
CAS :<p>FM-479, a structural analog of FM-381, lacks inhibition of JAK3/kinases within 100-300 nM, serving as FM-381's negative control.</p>Formule :C25H26N6O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :442.523UNC4203
CAS :<p>UNC4203 inhibits MERTK (1.2 nM), AXL (140 nM), TYRO3 (42 nM), FLT3 (90 nM); potent, selective, oral.</p>Formule :C30H44N6OCouleur et forme :SolidMasse moléculaire :504.71ALK/ROS1-IN-1
CAS :<p>ALK/ROS1-IN-1 is a potent and selective anti-crizotinib-resistant ALK/ROS1 dual inhibitor (IC50s: 0.530 μM and 0.174 μM for ROS1 and ALK enzyme).</p>Formule :C30H35F3N6O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :584.63JAK-IN-4
CAS :<p>JAK-IN-4 is a prodrug of a JAK inhibitor, effective in murine collagen induced arthritis model.</p>Formule :C18H21N4Na2O6PDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :466.341Ruxolitinib sulfate
CAS :<p>Ruxolitinib sulfate, a potent JAK1/2 inhibitor (IC50: 3.3/2.8 nM), is >130x more selective for JAK1/2 than JAK3.</p>Formule :C17H20N6O4SCouleur et forme :SolidMasse moléculaire :404.45Larixol
CAS :<p>Larixol acts as both an fMLP inhibitor and a modulator of various signaling pathways by inhibiting Src kinase, ERK1/2, p38, and AKT phosphorylation critical for</p>Formule :C20H34O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :306.48PF-06459988
CAS :PF-06459988 is a novel, effective, orally active, irreversible, and selective epidermal growth factor receptor (EGFR) mutant inhibitor.Formule :C19H22ClN7O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :431.88EGFR-IN-33
CAS :<p>EGFR-IN-33, a low-toxicity acrylamide, inhibits EGFR, aiding against cancer, especially NSCLC (from WO2021185348A1, comp. 13).</p>Formule :C26H25ClN6O2Couleur et forme :SolidMasse moléculaire :488.97BTK inhibitor 13
CAS :<p>BTK inhibitor 13 (compound 8) is an effective and selective BTK inhibitor(IC50: 1.2 nM).</p>Formule :C29H26FN5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :511.55(Z)-RG-13022
CAS :<p>(Z)-RG-13022 is a tyrosine kinase (TK) inhibitor that preferentially inhibits the TK activity of the EGF receptor, restricting the EGF-stimulated growth of cultured cells. It demonstrates an IC50 of 11 μM for DNA synthesis in HN5 cells, showcasing thrice the potency of its isomer, (E)-RG-13022 (IC50 = 38 μM). This compound is applied in breast cancer cell research [1] [2].</p>Formule :C16H14N2O2Couleur et forme :SolidMasse moléculaire :266.29CT-721
CAS :<p>CT-721: potent, time-bound Bcr-Abl inhibitor, IC50 21.3 nM, effective against CML.</p>Formule :C30H29ClN6ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :525.04FGFR-IN-4
CAS :<p>FGFR-IN-4 is a potent inhibitor of FGFR. FGFR-IN-4 has potential for cancer disease studies.</p>Formule :C24H21N7O2Couleur et forme :SolidMasse moléculaire :439.47HPK1-IN-2 dihydrochloride
CAS :<p>HPK1-IN-2 dihydrochloride, a potent and orally active inhibitor of hematopoietic progenitor kinase-1 (HPK1) with an IC 50 of less than 0.05 µM, demonstrates significant antitumor activity. It additionally exhibits inhibition of Lck kinase activity, with an IC 50 ranging from 0.05 to less than 0.5 µM, and Flt3 kinase activity, with an IC 50 of less than 0.05 µM [1].</p>Formule :C19H22Cl2N6OSCouleur et forme :SolidMasse moléculaire :453.39CCT365623 hydrochloride
CAS :<p>CCT365623 hydrochloride is an orally active inhibitor of lysyl oxidase (LOX) (IC50: 0.89 μM). It suppresses EGFR (pY1068) and AKT phosphorylation driven by EGF.</p>Formule :C18H18ClNO4S3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :443.99BGB-102
CAS :<p>BGB-102 (JNJ-26483327) is a kinase inhibitor targeting FLT3 and YES1 and an antagonist targeting EGFR and VEGFR3.</p>Formule :C22H25BrN4O2Degré de pureté :99.02%Couleur et forme :SolidMasse moléculaire :457.36TIE-2/VEGFR-2 kinase-IN-4
CAS :<p>TIE-2/VEGFR-2 kinase-IN-4, a benzimidazole derivative, serves as a potent inhibitor of the tyrosine kinase receptors TIE-2 and VEGFR-2, exhibiting inhibitory</p>Formule :C26H17F4N5O4Couleur et forme :SolidMasse moléculaire :539.44Nezulcitinib
CAS :<p>Nezulcitinib (TD-0903) is an inhaled pan-JAK inhibitor targeting COVID-19-related acute lung injury.</p>Formule :C30H37N7O2Couleur et forme :SolidMasse moléculaire :527.66AT-9283 L-lactate
CAS :<p>AT-9283 L-lactate is an inhibitor of aurora kinase.</p>Formule :C22H29N7O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :471.52FC 11
CAS :<p>FC 11 is a reversible FAK PROTAC Degrader with DC50 of 40-370 pM and degrades pFAKtyr397 in TM3 cells within 3 hours at 100 nM.</p>Formule :C41H42F3N13O9SCouleur et forme :SolidMasse moléculaire :949.91HER2-IN-5
CAS :<p>HER2-IN-5 is an effective inhibitor of orally active HER-2.</p>Formule :C27H33N7O3Couleur et forme :SolidMasse moléculaire :503.6BPIQ-I
CAS :<p>BPIQ-I (PD 159121), an ATP-competitive EGFR tyrosine kinase inhibitor, exhibits potent anti-proliferative activity.</p>Formule :C16H12BrN5Couleur et forme :SolidMasse moléculaire :354.2Nazartinib S-enantiomer
CAS :<p>Nazartinib is an EGFR inhibitor. Nazartinib S-enantiomer is the less active S-enantiomer of Nazartinib.</p>Formule :C26H31ClN6O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :495.02EGFR-IN-32
CAS :<p>EGFR-IN-32, a potent EGFR blocker, shows promise for EGFR-mutated illnesses. (Patent WO2021185297A1, compound 2)</p>Formule :C31H34N6O3Couleur et forme :SolidMasse moléculaire :538.64HDAC-IN-63
CAS :<p>HDAC-IN-63 (Compound 63) is a dual FLT3/HDAC inhibitor with IC50 values of 0.844 nM for FLT3 and 30.0 nM for HDAC1.</p>Formule :C25H26Cl2N6O3Couleur et forme :SolidMasse moléculaire :529.42KB SRC 4
CAS :KB SRC 4 is a selective and potent c-Src inhibitor with antitumour activity that inhibits the growth of cancer cells.CAS 번호13460-73-83-4Formule :C32H23ClN8Degré de pureté :98.83% - 99.34%Couleur et forme :SolidMasse moléculaire :555.03PI3K/VEGFR2-IN-1
CAS :<p>PI3K/VEGFR2-IN-1 is a potent dual inhibitor targeting both PI3K and VEGFR2 with IC50 values of 2.21 μM for PI3K and 68 μM for VEGFR2, respectively.</p>Formule :C17H14ClN3OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :343.83Sulfatinib
CAS :<p>Sulfatinib (KDR-IN-1) (HMPL-012) is a potent and highly selective tyrosine kinase inhibitor against VEGFR1/2/3, FGFR1 and CSF1R with IC 50 s ranging from 1 to</p>Formule :C24H28N6O3SDegré de pureté :99.21% - >99.99%Couleur et forme :SolidMasse moléculaire :480.58DZD1516
CAS :<p>DZD1516, a potent and selective HER2 inhibitor (IC50 = 0.56 nM), demonstrates good blood-brain barrier permeability and exhibits antitumor activity in both</p>Formule :C28H27F2N7O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :547.56TIE-2/VEGFR-2 kinase-IN-5
CAS :TIE-2/VEGFR-2 kinase-IN-5 is a TIE-2 and VEGFR-2 tyrosine kinase receptor inhibitor commonly used in biomedical research related to angiogenesis.Formule :C21H13F6N5O2Degré de pureté :99.79%Couleur et forme :SolidMasse moléculaire :481.35Upadacitinib tartrate
CAS :<p>Upadacitinib: potent, selective JAK1 inhibitor, 74x preferential to JAK2, effective in rat arthritis.</p>Formule :C21H33F3N6O11Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :602.521EGFR-IN-74
<p>EGFR-IN-74 is a potent inhibitor targeting EGFR, specifically effective against the L858R/T790M mutations, exhibiting an IC50 value of 138 nM.</p>Formule :C32H28BrF3N6O4SCouleur et forme :SolidMasse moléculaire :729.57FLT3/ITD-IN-4
CAS :<p>FLT3/ITD-IN-4 inhibits FLT3-ITD mutations in acute myeloid leukemia (IC50: 2.3 nM).</p>Formule :C25H22N4O5Couleur et forme :SolidMasse moléculaire :458.47EGFR-IN-30
CAS :<p>EGFR-IN-30 is an EGFR inhibitor (IC50: 1-10 nM, <1 nM WT/mutants) with potential in cancer research.</p>Formule :C28H33BrN7O2PCouleur et forme :SolidMasse moléculaire :610.49FGFR-IN-2
CAS :<p>FGFR-IN-2 (compound 1) is a potent inhibitor of FGFR, acting on FGFR1 (IC50: 7.3 nM), FGFR2 (IC50: 4.3 nM), FGFR3 (IC50: 7.6 nM) and FGFR4 (IC50: 11 nM).</p>Formule :C25H30N6O2Couleur et forme :SolidMasse moléculaire :446.54IN-1130
CAS :<p>IN-1130: ALK5 inhibitor, IC50 - 5.3 nM (Smad3), 36 nM (casein), 4.3 μM (p38α MAPK).</p>Formule :C25H20N6ODegré de pureté :99.79%Couleur et forme :SolidMasse moléculaire :420.47Sevabertinib
CAS :<p>Sevabertinib (BAY 2927088) is an EGFR tyrosine kinase inhibitor, with anticancer activity, used in research on non-small cell lung cancer.</p>Formule :C24H25ClN4O5Degré de pureté :99.81%Couleur et forme :SolidMasse moléculaire :484.93BMS-935177
CAS :<p>BMS-935177 is a reversible BTK inhibitor with IC50 value of 3 nM.</p>Formule :C31H26N4O3Degré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :502.56KER047
CAS :ALK2-IN-4, a highly effective ALK2 inhibitor.Formule :C26H30FN7ODegré de pureté :98.49% - >99.99%Couleur et forme :SolidMasse moléculaire :475.56Zongertinib
CAS :<p>Zongertinib is a human HER2-selective tyrosine kinase inhibitor, a novel TK that is highly selective for covalent binding to the HER2 tyrosine kinase domain (</p>Formule :C29H29N9O2Degré de pureté :98.24%Couleur et forme :SolidMasse moléculaire :535.6Ifebemtinib
CAS :Ifebemtinib (BI-853520) is an adhesion plaque kinase inhibitor with anti-tumour activity for the study of breast cancer.Formule :C28H28F4N6O4Degré de pureté :98.84% - 99.85%Couleur et forme :SolidMasse moléculaire :588.55
