FAK
Les inhibiteurs de la kinase d'adhésion focale (FAK) ciblent la FAK, une kinase impliquée dans l'adhésion cellulaire, la migration et l'angiogenèse. La FAK est fréquemment surexprimée dans les tumeurs et contribue à la formation de nouveaux vaisseaux sanguins qui alimentent la tumeur en nutriments. L'inhibition de la FAK peut perturber ces processus, faisant des inhibiteurs de la FAK des outils précieux en thérapie anticancéreuse et en recherche sur l'angiogenèse. Chez CymitQuimica, nous offrons une gamme complète d'inhibiteurs de la FAK de haute qualité pour soutenir vos recherches en biologie cellulaire, cancer et angiogenèse.
72 produits trouvés pour "FAK"
Trier par
Degré de pureté (%)
0
100
|
0
|
50
|
90
|
95
|
100
Chloropyramine hydrochloride
CAS :<p>Chloropyramine hydrochloride (Alergosan) is a histamine receptor H1 antagonist.</p>Formule :C16H20ClN3·HClDegré de pureté :99.45% - 99.8%Couleur et forme :SolidMasse moléculaire :326.26ALK inhibitor 1
CAS :<p>ALK inhibitor 1 is a selective ALK kinase inhibitor.</p>Formule :C23H28BrN7O3SDegré de pureté :98.27%Couleur et forme :SolidMasse moléculaire :562.48ALK inhibitor 2
CAS :<p>ALK inhibitor 2 is a new-type and selective inhibitor for the ALK kinase.</p>Formule :C23H28ClN7O3SDegré de pureté :99.77% - >99.99%Couleur et forme :SolidMasse moléculaire :518.03Ifebemtinib FA
<p>BI-853520 FA (Ifebemtinib FA) is an orally active inhibitor of adhesion patch kinase with anticancer and antiproliferative activity for ovarian and lung cancer.</p>Formule :C29H30F4N6O6Degré de pureté :98.05% - 99.73%Couleur et forme :SolidMasse moléculaire :634.58Lewis y tetrasaccharide
CAS :<p>Lewis Y tetrasaccharide, a derivative of Lewis X, is an antigen linked to ovarian cancer metastasis and bad prognosis.</p>Formule :C26H45NO19Couleur et forme :SolidMasse moléculaire :675.63GSK215
CAS :<p>GSK215: potent, selective PROTAC degrader of FAK (pDC50=8.4), combines FAK inhibitor VS-4718 and VHL E3 ligase binder, causes fast, lasting FAK degradation.</p>Formule :C50H59F3N10O6SDegré de pureté :99.3%Couleur et forme :SoildMasse moléculaire :985.13Defactinib analogue-1
CAS :<p>Defactinib analogue-1 (Compound 7) serves as a ligand for the target protein FAK, and is utilized in the synthesis of PROTAC FAK degrader 1.</p>Formule :C20H20F3N5O3SCouleur et forme :SolidMasse moléculaire :467.47FAK PROTAC B5
CAS :<p>FAK PROTAC B5: a degrader with 14.9 nM IC50, strong degradation, anti-growth, good plasma stability, and fair permeability.</p>Formule :C41H43ClN10O7Couleur et forme :SolidMasse moléculaire :823.32119738-71-3
CAS :<p>Compound 2119738-71-3 interacts with the FAK receptor.</p>Formule :C25H29ClFN7O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :513.99FAK-IN-9
CAS :<p>FAK-IN-9 (8f) is a potent oral FAK inhibitor, IC50 of 27.44 nM; induces TNBC cell apoptosis.</p>Formule :C36H38ClN7O8SCouleur et forme :SolidMasse moléculaire :764.25FAK-IN-7
CAS :<p>FAK-IN-7 has potential antiproliferative activity and is a FAK inhibitor.</p>Formule :C16H13N3OSDegré de pureté :98.18%Couleur et forme :SolidMasse moléculaire :295.36Tyrosine Kinase Inhibitor Library
<p>A unique collection of 1016 tyrosine kinase inhibitors for high throughput screening and high content screening for drug discovery in tyrosine kinase related</p>Couleur et forme :Odour SolidAdhesamine diTFA
CAS :<p>Adhesamine diTFA, a dumbbell-shaped molecule, activates the MAPK/FAK pathway. It promotes adhesion and growth in mammalian cells and accelerates differentiation and enhances the survival rate of primary cultured mouse hippocampal neurons.</p>Formule :C28H32Cl2F6N8O6S2Couleur et forme :SolidMasse moléculaire :825.63VnP-16
<p>VnP-16 enhances bone formation by stimulating the differentiation and activity of osteoblasts via direct β1 integrin engagement, which subsequently activates</p>Formule :C82H112N20O17Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1649.89FAK-IN-1
CAS :<p>FAK-IN-1 is a FAK inhibitor with anticancer activities (WO2020231726 (Example 27)).</p>Formule :C24H26F3N7O4SCouleur et forme :SolidMasse moléculaire :565.57FAK-IN-10
CAS :<p>FAK-IN-10 is an inhibitor of FAK (IC50:76.3 μM).FAK-IN-10 z MCF-7 and A431 cell lines showed antitumor activity with IC50 of 4.23 and 0.78 μM, respectively.</p>Formule :C15H10BrN3O2SDegré de pureté :99.78%Couleur et forme :SoildMasse moléculaire :376.23MLK3-IN-1
<p>MLK3-IN-1 (Compound 37) is a selective inhibitor of mixed-lineage kinase 3 (MLK3) with an IC50 of less than 1 nM. It also inhibits FAK with an IC50 of 15.5 μM. In both murine and human liver microsomes, MLK3-IN-1 demonstrates excellent metabolic stability.</p>Formule :C20H16F6N4O2SCouleur et forme :SolidMasse moléculaire :490.422MY-1576
<p>MY-1576 is a FAK inhibitor with an IC50 of 8 nM. It activates the Hippo pathway, thereby inhibiting YAP/TAZ regulation. Additionally, MY-1576 effectively suppresses tumor growth in the KYSE30 xenograft mouse model, demonstrates good safety, and efficiently downregulates FAK autophosphorylation and YAP/TAZ levels in vivo.</p>Formule :C25H29ClN8O2Couleur et forme :SolidMasse moléculaire :509FAK-IN-27
<p>FAK-IN-27 (compound 8A) is a potent and selective inhibitor of FAK, with an IC50 of 4.968 nM. It effectively inhibits the proliferation of H1299 cells, with an IC50 of 0.28 μM, and is applicable for research in non-small cell lung cancer (NSCLC).</p>Formule :C32H28ClN5O6Couleur et forme :SolidMasse moléculaire :613.17281FAK-IN-14
CAS :<p>FAK-IN-14 is a FAK inhibitor that induces apoptosis and cell cycle arrest. FAK-IN-14 has a more significant inhibitory effect on FAK, FGFR1 and Pyk2.</p>Formule :C21H24BrN7OSDegré de pureté :99.7%Couleur et forme :SoildMasse moléculaire :502.43
