ROCK
Les inhibiteurs de la protéine kinase associée à Rho (ROCK) ciblent les kinases ROCK, qui sont impliquées dans la régulation du cytosquelette, de la forme cellulaire et de la motilité. ROCK joue un rôle significatif dans le contrôle de la division cellulaire, notamment dans des processus tels que la cytokinèse. Inhiber ROCK peut entraîner des changements dans la dynamique du cycle cellulaire, la motilité cellulaire et l'apoptose, ce qui rend ces inhibiteurs précieux dans la recherche sur le cancer, la neurobiologie et les études cardiovasculaires. Chez CymitQuimica, nous offrons une sélection d'inhibiteurs de ROCK de haute qualité pour soutenir vos recherches en biologie cellulaire, dynamique du cytosquelette et mécanismes des maladies.
63 produits trouvés pour "ROCK"
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Y-33075 dihydrochloride
CAS :Y-33075 dihydrochloride is a selective inhibitor of ROCK(IC50 of 3.6 nM).Formule :C16H18Cl2N4ODegré de pureté :98.88% - 99.89%Couleur et forme :SolidMasse moléculaire :353.25Ref: TM-T13384L
1mg34,00€5mg66,00€10mg102,00€25mg192,00€50mg341,00€100mg510,00€200mg732,00€1mL*10mM (DMSO)78,00€Netarsudil Dihydrochloride
CAS :Netarsudil Dihydrochloride (AR-13324 Dihydrochloride) is an inhibitor of Rho-related protein kinase (ROCK) and norepinephrine transporter (NET) and is effective in reducing intraocular pressure (IOP).Cost-effective and quality-assured.Formule :C28H29Cl2N3O3Degré de pureté :99.94% - 99.98%Couleur et forme :SolidMasse moléculaire :526.45ROCK inhibitor-2
CAS :ROCK inhibitor-2 is a selective dual inhibitor of ROCK1 and ROCK2 (IC50s of 17 nM and 2 nM, respectively).Formule :C21H20N2O2Degré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :332.4Ref: TM-T12746
1mg66,00€5mg144,00€10mg216,00€25mg432,00€50mg645,00€100mg905,00€1mL*10mM (DMSO)106,00€CMPD101
CAS :CMPD101 is a membrane-permeable small-molecule inhibitor of GRK2/3 (IC50: 18 nM and 5.4 nM).Formule :C24H21F3N6ODegré de pureté :99.01% - 99.04%Couleur et forme :SolidMasse moléculaire :466.46Akt/ROCK-IN-1
Akt/ROCK-IN-1 (B12) is a dual inhibitor targeting Akt and ROCK, exhibiting IC50 values of 0.023 nM and 1.47 nM, respectively.Formule :C21H19BrF2N4O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :509.37Ripasudil free base
CAS :Ripasudil free base (K-115 (free base)) is a selective and potent ROCK inhibitor, is a novel and potent antiglaucoma agent.Formule :C15H18FN3O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :323.39Ref: TM-T7492
1mg75,00€5mg150,00€10mg238,00€25mg530,00€50mg873,00€100mg1.459,00€1mL*10mM (DMSO)166,00€LX-7101 hydrochloride
CAS :LX-7101 hydrochloride is a potent LIMK and ROCK2 inhibitor with antihypertensive activity, inhibits LIMK1/2, ROCK, PKA, and can be used to study glaucoma.
Formule :C23H29N7O3xHClDegré de pureté :98.96%Couleur et forme :SolidMasse moléculaire :487.99ROCK2-IN-9
ROCK2-IN-9 (compound 7u), a selective ROCK2 inhibitor with an IC50 value of 36.8 nM, demonstrates anticancer properties by impeding cancer cell migration and invasion. This action is achieved through the regulation of various actin cytoskeleton cellular activities. It holds potential for use in breast cancer research.Formule :C28H30N8O2Couleur et forme :SolidMasse moléculaire :510.59Fasudil
CAS :Fasudil (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK.Formule :C14H17N3O2SDegré de pureté :99.79% - 99.84%Couleur et forme :SolidMasse moléculaire :291.37WAY-656935
CAS :WAY-656935 inhibits ROCK.Formule :C20H28ClN3O3SDegré de pureté :97%Couleur et forme :SolidMasse moléculaire :425.97GKI-1 HCl
GKI-1 HCl is a Greatwall (GWL) kinase inhibitor that inhibits hGWLFL and hGWL-KinDom.The inhibitory effect of GKI-1 HCl on ROCK1 is more significant.Formule :C15H13Cl2N3Degré de pureté :98.1%Couleur et forme :SoildMasse moléculaire :306.19Ref: TM-T11402L
1mg71,00€5mg154,00€10mg221,00€25mg354,00€50mg497,00€100mg705,00€200mg928,00€1mL*10mM (DMSO)167,00€GSK269962A hydrochloride
CAS :GSK269962A hydrochloride (GSK 269962 hydrochloride) is a ROCK inhibitor with anti-inflammatory and vasodilatory effects and inhibits ROCK1 and ROCK2.Formule :C29H31ClN8O5Couleur et forme :SolidMasse moléculaire :607.06Belumosudil mesylate
CAS :Belumosudil mesylate (KD025 mesylate) is a ROCK2 inhibitor with antifibrotic activity, and can be used in chronic graft-versus-host disease research.Formule :C27H28N6O5SDegré de pureté :98.73%Couleur et forme :SolidMasse moléculaire :548.61Ref: TM-T39555
1mg35,00€2mg48,00€5mg74,00€10mg92,00€25mg163,00€50mg243,00€100mg373,00€200mg547,00€1mL*10mM (DMSO)89,00€Verosudil
CAS :Verosudil (AR-12286), a ROCK1/2 inhibitor (Ki: 2 nM), lowers intraocular pressure in mice by enhancing aqueous outflow.Formule :C17H17N3O2SDegré de pureté :99.68%Couleur et forme :SolidMasse moléculaire :327.4Ref: TM-T60924
1mg55,00€5mg147,00€10mg231,00€25mg370,00€50mg522,00€100mg692,00€1mL*10mM (DMSO)161,00€Cotosudil
CAS :Cotosudil is a ROCK kinase inhibitor with antihypertensive activity used to treat or prevent neurodegenerative diseases.Formule :C16H21N3O2SDegré de pureté :98.41%Couleur et forme :SolidMasse moléculaire :319.42Narciclasine
CAS :Narciclasine (Lycoricidinol), a natural product, modulates the Rho/Rho-kinase/LIM kinase/cofilin signaling pathway, greatly increasing GTPase RhoA activity.Formule :C14H13NO7Degré de pureté :98.16% - 99.58%Couleur et forme :SolidMasse moléculaire :307.26SAR407899
CAS :SAR407899 is Rho kinase inhibitor potently inhibits endothelin-1-induced constriction of renal resistance arteries.Formule :C14H16N2O2Degré de pureté :99.42%Couleur et forme :SolidMasse moléculaire :244.29Ref: TM-T7391
2mg34,00€5mg50,00€10mg75,00€25mg128,00€50mg200,00€100mg319,00€200mg474,00€1mL*10mM (DMSO)55,00€SR-3677
CAS :SR-3677 is an effective and specific inhibitor of ROCK2 (IC50: 3 nM).Formule :C22H24N4O4Degré de pureté :98.46%Couleur et forme :SolidMasse moléculaire :408.45SAR407899 hydrochloride
CAS :SAR407899 hydrochloride is a selective, potent and ATP-competitive ROCK inhibitor, with an IC50 of 135 nM for ROCK-2, and Kis of 36 nM and 41 nM for human andFormule :C14H17ClN2O2Degré de pureté :99.15%Couleur et forme :SolidMasse moléculaire :280.75RKI1313
CAS :RKI1313 (RKI-1313) was a selective inhibitor for ROCK-dependent signaling, cytoskeletal changes, anchorage-independent colony formation, migration, and invasionFormule :C17H16N4O2SDegré de pureté :99.53% - ≥95%Couleur et forme :SolidMasse moléculaire :340.4Ref: TM-T2011
1mg70,00€5mg142,00€10mg207,00€25mg369,00€50mg540,00€100mg772,00€500µg49,00€1mL*10mM (DMSO)160,00€
