Chromatine/Épigénétique
Les inhibiteurs de la chromatine/épigénétique sont des composés qui modulent la structure et la fonction de la chromatine ou interfèrent avec les modifications épigénétiques, telles que la méthylation de l'ADN et la modification des histones. Ces inhibiteurs sont des outils essentiels pour étudier la régulation de l'expression génique et le rôle de l'épigénétique dans des maladies telles que le cancer, les troubles neurologiques et les anomalies du développement. En ciblant les processus épigénétiques, ces inhibiteurs peuvent modifier les schémas d'expression génique et offrir de nouvelles perspectives thérapeutiques. Chez CymitQuimica, nous offrons une large sélection d'inhibiteurs de la chromatine/épigénétique de haute qualité pour soutenir vos recherches en biologie moléculaire, génétique et épigénétique.
Sous-catégories appartenant à la catégorie "Chromatine/Épigénétique"
2235 produits trouvés pour "Chromatine/Épigénétique"
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Decitabine
CAS :<p>Decitabine (Deoxycytidine) is a deoxycytidine analog, a DNA methyltransferase inhibitor with oral activity.</p>Formule :C8H12N4O4Degré de pureté :98.06% - 99.87%Couleur et forme :Physical Description Fine White Crystalline Powder Used As A DrugMasse moléculaire :228.21Levetiracetam
CAS :<p>Levetiracetam (SIB-S1) is a relatively unique anticonvulsant that is typically used in combination with other antiepileptic medications for partial onset</p>Formule :C8H14N2O2Degré de pureté :99.67% - 99.86%Couleur et forme :White Crystalline PowderMasse moléculaire :170.21Deferoxamine Mesylate
CAS :<p>Deferoxamine Mesylate (DFOM) is an iron chelator and iron death inhibitor.</p>Formule :C26H52N6O11SDegré de pureté :94.68% - 99.8%Couleur et forme :SolidMasse moléculaire :656.79VTP50469
CAS :<p>VTP50469 is a highly selective and orally active small molecule inhibitor of the Menin-MLL protein-protein interaction.Cost-effective and quality-assured.</p>Formule :C32H47FN6O4SDegré de pureté :98.31% - 99.55%Couleur et forme :SolidMasse moléculaire :630.82TRIM24/BRPF1-IN-2
CAS :<p>TRIM24/BRPF1-IN-2 is a TRIM24/BRPF1 dual inhibitor with anticancer activity that inhibits the proliferation of prostate cancer cells.</p>Formule :C20H22N2O4SDegré de pureté :98.69% - 99.13%Couleur et forme :SoildMasse moléculaire :386.47Tulmimetostat
CAS :<p>Tulmimetostat (CPI-0209) is an orally active EZH1/EZH2 inhibitor.Tulmimetostat has antitumor activity and is used in the study of ovarian cancer and advanced</p>Formule :C28H36ClN3O5SDegré de pureté :98.04% - 99.872%Couleur et forme :SolidMasse moléculaire :562.12Indoprofen
CAS :<p>Indoprofen ((±)-Indoprofe) is a non-steroidal anti-inflammatory drug.</p>Formule :C17H15NO3Degré de pureté :99.34%Couleur et forme :SolidMasse moléculaire :281.31Ilginatinib
CAS :<p>Ilginatinib (NS-018) is a highly active and orally bioavailable inhibitor of JAK2.</p>Formule :C21H20FN7Degré de pureté :98.4% - 99.01%Couleur et forme :SolidMasse moléculaire :389.43dAURK-4 hydrochloride
<p>dAURK-4 hydrochloride, a derivative of Alisertib, functions as a potent and selective degrader of AURKA (Aurora A), exhibiting anticancer properties [1].</p>Formule :C52H53Cl2FN8O12Degré de pureté :99.44%Couleur et forme :SolidMasse moléculaire :1071.93Nimucitinib
CAS :<p>Nimucitinib is a Janus kinase (JAK) inhibitor that can be used to treat dry eye and promote tear production.</p>Formule :C25H26F2N6O2Degré de pureté :98.71%Couleur et forme :SoildMasse moléculaire :480.51Minocycline hydrochloride
CAS :<p>Minocycline HCl: tetracycline antibiotic, treats bacterial infections and acne, may cause acute or chronic hepatitis.</p>Formule :C23H28ClN3O7Degré de pureté :99.28% - >99.99%Couleur et forme :Bright Yellow-Orange Amorphous Solid Crystalline YellowMasse moléculaire :493.94MAT2A inhibitor 2
CAS :<p>MAT2A inhibitor 2 is an inhibitor of methionine adenosyltransferase 2A (MAT2A).</p>Formule :C18H24ClN3O3Degré de pureté :99.52%Couleur et forme :SolidMasse moléculaire :365.85PKC β pseudosubstrate acetate
<p>PKC β pseudosubstrate acetate (PKC β pseudosubstrate acetate (172308-76-8 Free base)) is a selective cell-permeable inhibitor of PKC.</p>Degré de pureté :95.42%Couleur et forme :SoildTAK-901
CAS :<p>TAK-901 has been used in trials studying the treatment of Lymphoma, Myelofibrosis, Multiple Myeloma, Myeloid Metaplasia, and Advanced Solid Tumors, among others</p>Formule :C28H32N4O3SDegré de pureté :99.02% - 99.59%Couleur et forme :SolidMasse moléculaire :504.64Nicotinamide riboside
CAS :<p>Nicotinamide riboside increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high fat diet-</p>Formule :C11H15N2O5Degré de pureté :98.82% - 99.58%Couleur et forme :SolidMasse moléculaire :255.25Diperodon hydrochloride
CAS :<p>Diperodon hydrochloride (Diperocaine) is a local anesthetic that can be broken down by serolytic enzymes to produce local anesthetic effects.</p>Formule :C22H28ClN3O4Degré de pureté :99.91%Couleur et forme :SolidMasse moléculaire :433.935-Azacytidine
CAS :<p>5-Azacytidine (Ladakamycin) is a cytidine nucleoside analog, a DNA methylation inhibitor with specificity.</p>Formule :C8H12N4O5Degré de pureté :99.31% - 99.79%Couleur et forme :Crystals From Methanol Physical Description White Crystalline Powder (Ntp 1992)Masse moléculaire :244.2Cyproheptadine hydrochloride sesquihydrate
CAS :<p>Cyproheptadine hydrochloride sesquihydrate (Peritol), an antihistamine, is an antagonist of serotonin and histamine2.</p>Formule :C21H24ClNODegré de pureté :99.77% - >99.99%Couleur et forme :White To Slightly Yellowish Crystalline SolidMasse moléculaire :341.88HIF-2α-IN-2
CAS :<p>HIF-2α-IN-2 is a hypoxia-inducible factor (HIF-2α) inhibitor (IC50: 16 nM in scintillation proximity assay).</p>Formule :C17H13F2NO4SDegré de pureté :99.24%Couleur et forme :SolidMasse moléculaire :365.35Dihydro-5-azacytidine FA
<p>Dihydro-5-azacytidine FA (DHAC) is a pyrimidine analog that has antitumor activity, inhibits cell growth, inhibits DNA methylation, and may be used in the study of malignant mesothelioma.</p>Formule :C9H16N4O7Degré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :292.25Roxadustat
CAS :<p>Roxadustat (FG-4592) is an orally bioavailable, hypoxia-inducible factor prolyl hydroxylase inhibitor (HIF-PHI), with potential anti-anemic activity.</p>Formule :C19H16N2O5Degré de pureté :99% - 99.88%Couleur et forme :SolidMasse moléculaire :352.34Dehydrocorydaline chloride
CAS :<p>Dehydrocorydaline chloride (13-Methylpalmatine chloride) is an alkaloid with anti-inflammatory and anti-cancer activity. Can improve the activation of p38 MAPK.</p>Formule :C22H24ClNO4Degré de pureté :99.53%Couleur et forme :SolidMasse moléculaire :401.88Acetaminophen
CAS :<p>Acetaminophen: pain reliever, fever reducer; mild anti-inflammatory. Risks: liver, kidney damage, blood cell effects.</p>Formule :C8H9NO2Degré de pureté :99.85% - 99.99%Couleur et forme :Colourless Solid CrystallineMasse moléculaire :151.16Delgocitinib
CAS :<p>Delgocitinib is a potent JAK inhibitor (IC50: 2.8-58 nM), treats inflammatory diseases, and is the first topical drug for atopic dermatitis.</p>Formule :C16H18N6ODegré de pureté :99.95%Couleur et forme :SolidMasse moléculaire :310.35MS402
CAS :<p>MS402 is a novel BD1-selective BET BrD inhibitor.</p>Formule :C20H19ClN2O3Degré de pureté :99.72%Couleur et forme :SolidMasse moléculaire :370.83WDR5-IN-6
CAS :<p>WDR5-IN-6 is a WDR5 inhibitor targeting the WBM locus.WDR5-IN-6 is highly synergistic with OICR-9429, a WDR5 inhibitor that targets the WIN locus.WDR5-IN-6</p>Formule :C13H8Cl2N2O2SDegré de pureté :99.69%Couleur et forme :SoildMasse moléculaire :327.19(R)-CR8
CAS :<p>(R)-CR8 ((R)-Isomer) is a potent and selective CDK inhibitor.</p>Formule :C24H29N7ODegré de pureté :98.41%Couleur et forme :SolidMasse moléculaire :431.53JAK2 Inhibitor V
CAS :<p>JAK2 Inhibitor V (JAK2 Inhibitor V Z3) is a novel specific inhibitor of Jak2, inhibiting Jak2-V617F and Jak2-WT autophosphorylation in a dose-dependent manner.</p>Formule :C23H24N2ODegré de pureté :98.36% - 99.15%Couleur et forme :SolidMasse moléculaire :344.45Glucosamine hydrochloride
CAS :<p>Glucosamine hydrochloride (Chitosamine hydrochloride) is commonly used as a treatment for osteoarthritis, although its acceptance as a medical therapy varies.</p>Formule :C6H13NO5·HClDegré de pureté :99.77%Couleur et forme :White Solid CrystallineMasse moléculaire :215.63LIN28 inhibitor LI71
CAS :<p>LIN28 inhibitor LI71 is a potent and cell-permeable LIN28 inhibitor, which abolishes LIN28-mediated oligouridylation with an IC50 of 7 uM.</p>Formule :C21H21NO3Degré de pureté :95.88%Couleur et forme :SolidMasse moléculaire :335.4Diflunisal
CAS :<p>Diflunisal (Dolobid) is a cyclooxygenase (COX) Inhibitor, used as an anti-inflammatory analgesic.</p>Formule :C13H8F2O3Degré de pureté :98.92% - 99.42%Couleur et forme :SolidMasse moléculaire :250.20DC-05
CAS :<p>DC-05 is an inhibitor of DNA methyltransferase 1 (DNMT1) (IC50 and a Kd: 10.3 μM and 1.09 μM, respectively).</p>Formule :C25H25N3ODegré de pureté :98.95%Couleur et forme :SolidMasse moléculaire :383.49EHP-101
CAS :<p>EHP-101 is a PPARγ/CB2 dual agonist with anti-inflammatory properties, inhibits fat formation, and combats diet-related obesity.</p>Formule :C28H35NO3Degré de pureté :98.36%Couleur et forme :SolidMasse moléculaire :433.58N6-Cyclohexyladenosine
CAS :<p>N6-Cyclohexyladenosine (CHA) is a selective agonist of A1 receptor with EC50 of 8.2 Nm.</p>Formule :C16H23N5O4Degré de pureté :99.84% - 99.98%Couleur et forme :SolidMasse moléculaire :349.38Albendazole
CAS :<p>Albendazole (SKF-62979) is used as a drug indicated for the treatment of a variety of worm infestations.</p>Formule :C12H15N3O2SDegré de pureté :98.21% - 98.76%Couleur et forme :Colorless Crystals SolidMasse moléculaire :265.33Curcumin
CAS :<p>Curcumin (Natural Yellow 3) is a phenolic natural product, an inhibitor of histone acetyltransferase p300/CREB (IC50=25 μM) with specificity.</p>Formule :C21H20O6Degré de pureté :95% - 98.98%Couleur et forme :Orange-Yellow Crystal Powder; Gives Brownish-Red Color With Alkali; Light-Yellow Color With Acids Physical Description Orange-Yellow Needles (Ntp 1992)Masse moléculaire :368.3799EML 425
CAS :<p>EML 425 is a potent and selective inhibitor of CREB binding protein (CBP)/p300 (IC50s: 2.9 and 1.1 μM, respectively).</p>Formule :C27H24N2O4Degré de pureté :97.6%Couleur et forme :SolidMasse moléculaire :440.49Histone Acetyltransferase Inhibitor II
CAS :<p>Histone Acetyltransferase Inhibitor II is a selective and cell permeable inhibitor of p300 histone acetyltransferase(IC50 : 5 μM).with anti-acetylase activity</p>Formule :C20H16Br2O3Degré de pureté :97.13%Couleur et forme :SolidMasse moléculaire :464.15SYP-5
CAS :<p>SYP-5 is a novel inhibitor of HIF-1, suppresses tumor cells invasion and angiogenesis.</p>Formule :C18H16O3SDegré de pureté :98.31%Couleur et forme :SolidMasse moléculaire :312.38MOZ-IN-2
CAS :<p>MOZ-IN-2 is an protein MOZ inhibitor(IC50 of 125 μM).</p>Formule :C17H13FN4O3SDegré de pureté :99.17%Couleur et forme :SolidMasse moléculaire :372.37Amodiaquine dihydrochloride dihydrate
CAS :<p>Amodiaquine dihydrochloride dihydrate (Amodiaquin hydrochloride) is an orally active 4-aminoquinoline derivative with antimalarial and anti-inflammatory effects</p>Formule :C20H28Cl3N3O3Degré de pureté :99.97%Couleur et forme :SolidMasse moléculaire :464.82AW68
CAS :<p>AW68 is a potential small molecule BRD4 inhibitor that prevents and treats BRD4-related diseases and can be used in cancer research.</p>Formule :C22H21ClN6Degré de pureté :98.52% - 98.52%Couleur et forme :SoildMasse moléculaire :404.89MS417
CAS :<p>MS417 (GTPL7512) is an inhibitor of BET-specific BRD4(BRD4-BD1 and BRD4-BD2 with IC50s of 30, 46 nM and Kds of 36.1, 25.4 nM, respectively), with weak</p>Formule :C20H19ClN4O2SDegré de pureté :99.87%Couleur et forme :SolidMasse moléculaire :414.91Golidocitinib
CAS :<p>Golidocitinib (AZD4205) is a selective JAK1 inhibitor (IC50: 73 nM) and weakly inhibits JAK2/JAK3 (IC50: >14.7, >30 μM).</p>Formule :C25H31N9O2Degré de pureté :98.87% - 99.88%Couleur et forme :SolidMasse moléculaire :489.57BRD4 Inhibitor-10
CAS :<p>BRD4 Inhibitor-10 is an inhibitor of BRD4-BD1 (IC50: 8 nM).</p>Formule :C25H27N5O2Degré de pureté :99.53%Couleur et forme :SolidMasse moléculaire :429.51Valemetostat
CAS :<p>Valemetostat (DS-3201) is a first-in-class EZH1/2 dual inhibitor, which can be used to study T-cell lymphoma.Cost-effective and quality-assured.</p>Formule :C26H34ClN3O4Degré de pureté :98.38% - 99.08%Couleur et forme :SolidMasse moléculaire :488.02Chloramphenicol
CAS :<p>Chloramphenicol (Chloromycetin) is a broad-spectrum antibiotic that inhibits the biosynthesis of bacterial proteins. Cost-effective and quality-assured.</p>Formule :C11H12Cl2N2O5Degré de pureté :99.6% - 99.84%Couleur et forme :Needles Or Elongated Plates From Water Or Ethylene Dichloride SolidMasse moléculaire :323.13Niraparib (R-enantiomer)
CAS :<p>Niraparib R-enantiomer (MK 4827 R-enantiomer) is an inhibitor of PARP1(IC50 of 2.4 nM).</p>Formule :C19H20N4ODegré de pureté :99.83%Couleur et forme :SolidMasse moléculaire :320.39mTOR/HDAC-IN-1 HCl
<p>mTOR/HDAC-IN-1 HCl，a dual inhibitor of mTOR and HDAC with potential anti-inflammatory, anti-proliferative, autophagic and apoptosis-inducing effects for cancer</p>Formule :C23H24ClN11O3Degré de pureté :99.56%Couleur et forme :SoildMasse moléculaire :537.96Gusacitinib
CAS :<p>Gusacitinib (ASN-002) (ASN-002) is spleen tyrosine kinase (SYK) and janus kinase (JAK) inhibitor (IC50: 5-46 nM).</p>Formule :C24H28N8O2Degré de pureté :98.06% - 99.94%Couleur et forme :SolidMasse moléculaire :460.53MAK683
CAS :<p>MAK683 is an inhibitor of embryonic ectoderm development (EED) (IC50s: 59, 89, 26 nM in EED Alphascreen binding, LC-MS and ELISA assay).</p>Formule :C20H17FN6ODegré de pureté :98.25% - 99.92%Couleur et forme :SolidMasse moléculaire :376.39Nefiracetam
CAS :<p>Nefiracetam (DM9384), in Phase 2 trials, enhances GABA, choline, monoamine systems, and treats Ro 5-4864 convulsions.</p>Formule :C14H18N2O2Degré de pureté :97.37%Couleur et forme :White To Off-White Crystalline PowderMasse moléculaire :246.3Uzansertib phosphate
CAS :<p>Uzansertib phosphate (INCB053914 phosphate) is an orally active, ATP-competitive inhibitor of pan-PIM kinase, inhibiting PIM1, PIM2 and PIM3.</p>Formule :C26H29F3N5O7PDegré de pureté :99.75% - 99.79%Couleur et forme :SolidMasse moléculaire :611.51ZL0580
CAS :<p>ZL0580 suppresses HIV by blocking Tat activation, halting transcription, and promoting repressive chromatin at the HIV promoter.</p>Formule :C25H23F3N4O4SDegré de pureté :99.70%Couleur et forme :SolidMasse moléculaire :532.53Amifostine
CAS :<p>Amifostine (Ethyol) anhydrous is a cytoprotective agent, acts as a free radical scavenging activity.</p>Formule :C5H15N2O3PSDegré de pureté :99.88%Couleur et forme :White SolidMasse moléculaire :214.22A-485
CAS :<p>A-485 is a p300/CBP histone acetyltransferase (HAT) inhibitor that inhibits p300 and CBP. A-485 has antitumor effects. Cost effective and quality assured.</p>Formule :C25H24F4N4O5Degré de pureté :98.01% - 99.44%Couleur et forme :SolidMasse moléculaire :536.48Tranylcypromine (2-PCPA) hydrochloride
CAS :<p>Tranylcypromine (2-PCPA) HCl, a MAO inhibitor, treats major, dysthymic, and atypical depression.</p>Formule :C9H11N·HClDegré de pureté :99.48% - 99.86%Couleur et forme :SolidMasse moléculaire :169.66iso-Azalansta
CAS :<p>(2R,4S)-Azalanstat (Iso-Azalansta) is a selective heme oxygenase (HO) inhibitor that is used in the study of cardiovascular disease.</p>Formule :C22H24ClN3O2SDegré de pureté :99.53% - 99.89%Couleur et forme :SoildMasse moléculaire :429.96PT2399
CAS :<p>PT2399, an oral HIF-2 inhibitor, blocks HIF-2α/1β dimerization, showing strong in vivo antitumor effects.</p>Formule :C17H10F5NO4SDegré de pureté :98.8% - 99.45%Couleur et forme :SolidMasse moléculaire :419.32ODM-207
CAS :<p>ODM-207 (BET-IN-4) is a potent BRD4 inhibitor.</p>Formule :C22H21N3O3Degré de pureté :99.75%Couleur et forme :SolidMasse moléculaire :375.42Chitosan oligosaccharide
CAS :<p>Chitosan oligosaccharide (COS) is an oligomer of β-(1→4)-linked D-glucosamine.</p>Formule :C12H24N2O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :340.327Fenbendazole
CAS :<p>Fenbendazole (Fenbendazol) is an antinematodal benzimidazole used in veterinary medicine.</p>Formule :C15H13N3O2SDegré de pureté :99.74%Couleur et forme :White To Yellowish PowderMasse moléculaire :299.35Bufexamac
CAS :<p>Bufexamac (Bufexamic acid) is a COX inhibitor for IFN-α release with anti-inflammatory, analgesic, and antipyretic action.</p>Formule :C12H17NO3Degré de pureté :99.73%Couleur et forme :Acicular CrystalMasse moléculaire :223.27SMARCA-BD ligand 1 for Protac
CAS :<p>SMARCA-BD ligand 1 for Protac is a compound capable of binding to SMARCA2, the BAF ATPase subunit, based on the Protac technology for degrading SMARCA2</p>Formule :C14H17N5ODegré de pureté :99.93%Couleur et forme :SolidMasse moléculaire :271.32Miltefosine
CAS :<p>Miltefosine (HePC), effective oral drug for both visceral and cutaneous leishmaniasis, in clinical trials worldwide.</p>Formule :C21H46NO4PDegré de pureté :98% - 99.87%Couleur et forme :White To Off-White PowderMasse moléculaire :407.57L-2-Hydroxyglutaric acid disodium
CAS :<p>L-2-Hydroxyglutaric acid disodium may affect epigenetics and contribute to renal cancer, inhibiting Mi-CK (Km 2.52 mM, Ki 11.13 mM).</p>Formule :C5H6Na2O5Degré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :192.08ZEN-3694
CAS :<p>ZEN-3694 (ZEN 3694) is a bromo-structural domain extra-terminal inhibitor (BETi) with activity in androgen signaling inhibitor (ASI) resistance models and can</p>Formule :C19H19N5ODegré de pureté :98.88% - 99.48%Couleur et forme :SolidMasse moléculaire :333.39NU6140
CAS :<p>NU6140 is a selective inhibitor of CDK2-cyclin A (IC50, 0.41 μM).</p>Formule :C23H30N6O2Degré de pureté :98.33%Couleur et forme :SolidMasse moléculaire :422.52Brepocitinib P-Tosylate
CAS :<p>Brepocitinib P-Tosylate (PF-06700841 P-Tosylate) is a potent dual inhibitor of Janus kinase 1 (JAK1) and TYK2 (IC50s of 17 nM and 23 nM, respectively).</p>Formule :C25H29F2N7O4SDegré de pureté :99.82% - 99.97%Couleur et forme :SolidMasse moléculaire :561.6Hydralazine hydrochloride
CAS :<p>Hydralazine hydrochloride, an antihypertensive phthalazine, induces vasodilation and may inhibit tumor DNA methylation.</p>Formule :C8H9ClN4Degré de pureté :99.85% - 99.86%Couleur et forme :Yellow Crystals White Crystalline SolidMasse moléculaire :196.64Bendazol
CAS :<p>Bendazol (Dibazol) is always used as the drug for hypertension and cerebral Angiospasm.</p>Formule :C14H12N2Degré de pureté :98.7% - 99.87%Couleur et forme :White Or Almost White Crystalline PowderMasse moléculaire :208.26N-(3-Aminopropyl)cyclohexylamine
CAS :<p>N-(3-Aminopropyl)cyclohexylamine inhibits spermine synthase; used in neuro disease research.</p>Formule :C9H20N2Degré de pureté :98.05% - 98.82%Couleur et forme :Pale Yellow Clear LiquidMasse moléculaire :156.2685Ilginatinib maleate
CAS :<p>Ilginatinib maleate (NS-018 maleate) is a highly active and orally bioavailable inhibitor of JAK2.</p>Formule :C25H24FN7O4Degré de pureté :99.74% - 99.82%Couleur et forme :SolidMasse moléculaire :505.5CBP/p300-IN-3
CAS :<p>CBP/p300-IN-3 (P300/CBP-IN-3) is an inhibitor of p300/CBP histone acetyltransferase.</p>Formule :C24H29N7ODegré de pureté :97.38% - 98.08%Couleur et forme :SolidMasse moléculaire :431.53MS31 trihydrochloride (2366264-12-0 free base)
<p>MS31 trihydrochloride (2366264-12-0 free base) is a potent, highly affinity and selective fragment-like methyllysine reader protein spindlin 1 (SPIN1) inhibitor</p>Formule :C20H30Cl3N3O2Degré de pureté :99.69%Couleur et forme :SolidMasse moléculaire :450.83BVT948
CAS :<p>BVT948 is a protein tyrosine phosphatase (PTP) inhibitor.It can also inhibit lysine methyltransferase SETD8 (KMT5A) and several cytochrome P450 (P450) isoforms.</p>Formule :C14H11NO3Degré de pureté :98.87%Couleur et forme :SolidMasse moléculaire :241.24L002
CAS :<p>L002 is a potent inhibitor of acetyltransferase p300 with an IC50 of 1.98 μM, blocking histone and p53 acetylation, and may treat cardiac hypertrophy.</p>Formule :C15H15NO5SDegré de pureté :98.59%Couleur et forme :SolidMasse moléculaire :321.35Hydroxycitric acid tripotassium hydrate
CAS :<p>Hydroxycitric acid tripotassium hydrate (Potassium citrate monohydrate) effectively inhibits HIF, has antioxidation, anti-inflammation, and anti-tumor effects.</p>Formule :C6H7K3O8Degré de pureté :99.85%Couleur et forme :White Solid CrystallineMasse moléculaire :324.41PBIT
CAS :<p>PBIT is a JARID1 inhibitor with IC50: 3 μM for JARID1B, 6 μM for JARID1A, and 4.9 μM for JARID1C.</p>Formule :C14H11NOSDegré de pureté :99.61% - 99.83%Couleur et forme :SolidMasse moléculaire :241.31EBI-2511
CAS :<p>EBI-2511 is a highly potent and orally active inhibitor of EZH2 (IC50: 6 nM in Pfeffiera cell lines).</p>Formule :C34H48N4O4Degré de pureté :99.74%Couleur et forme :SolidMasse moléculaire :576.77M-89
CAS :<p>M-89, a potent menin inhibitor (Kd 1.4 nM), disrupts Menin-MLL interaction, offering possible MLL leukemia treatment.</p>Formule :C37H47N5O4SDegré de pureté :98.38%Couleur et forme :SolidMasse moléculaire :657.87Enarodustat
CAS :<p>Enarodustat (JTZ-951) is an orally active factor inhibitor of prolyl hydroxylase (EC50: 0.22 μM) and has the potential for renal anemia treatment.</p>Formule :C17H16N4O4Degré de pureté :99.73% - 99.75%Couleur et forme :SolidMasse moléculaire :340.33RBN-2397
CAS :<p>RBN-2397 is a potent, selective and orally active accross species NAD+ competitive PARP7 inhibitor with IC50 less than 3 nM.</p>Formule :C20H23F6N7O3Degré de pureté :98.48% - 99.8%Couleur et forme :SolidMasse moléculaire :523.43FIDAS-3
CAS :<p>FIDAS-3, a stilbene derivative and potent Wnt inhibitor with an IC50 of 4.9 μM for methionine S-adenosyltransferase 2A (MAT2A), exhibits anticancer activities</p>Formule :C16H15F2NDegré de pureté :97.75%Couleur et forme :SolidMasse moléculaire :259.29Inobrodib
CAS :<p>Inobrodib (CBP-IN-1) is a potent inhibitor of p300/CBP bromodomain.</p>Formule :C30H32F2N4O3Degré de pureté :98.91% - 99.18%Couleur et forme :SolidMasse moléculaire :534.6Molidustat
CAS :<p>Molidustat (BAY 85-3934) 是新型HIF-PH 抑制剂，对PHD1(IC50:480 nM)、PHD2(IC50:280 nM)、PHD3(IC50:450 nM)。</p>Formule :C13H14N8O2Degré de pureté :98.79%Couleur et forme :SolidMasse moléculaire :314.3N-Desmethyltamoxifen hydrochloride
CAS :<p>N-Desmethyltamoxifen hydrochloride is the major tamoxifen metabolite in humans.</p>Formule :C25H28ClNODegré de pureté :99.15%Couleur et forme :SolidMasse moléculaire :393.95A-395
CAS :<p>A-395 blocks PRC2 (EZH2-EED-SUZ12) interactions, strongly inhibiting the complex with an IC50 of 18 nM.</p>Formule :C26H35FN4O2SDegré de pureté :98.43%Couleur et forme :SolidMasse moléculaire :486.65Lin28-let-7a antagonist 1
CAS :<p>Lin28-let-7a antagonist 1, with an IC50 of 4.03 μM for Lin28A-let-7a-1 interaction，and shows a clear antagonistic effect against the Lin28-let-7a interaction.</p>Formule :C31H29N5O7Degré de pureté :99.44%Couleur et forme :SolidMasse moléculaire :583.59GNE-781
CAS :<p>GNE-781: potent CBP inhibitor (IC50: 0.94 nM), also targets BRET/BRD4(1) (IC50: 6.2/5100 nM).</p>Formule :C27H33F2N7O2Degré de pureté :99.64% - 99.92%Couleur et forme :SolidMasse moléculaire :525.59Pim-1 kinase inhibitor 8
CAS :<p>Pim-1 kinase inhibitor 8 is a Pim-1 kinase inhibitor with anticancer activity that inhibits cell migration and can be studied in breast cancer.</p>Formule :C14H17N3O3Degré de pureté :99.81%Couleur et forme :SoildMasse moléculaire :275.3SNDX-5613
CAS :<p>Revumenib (SNDX-5613) is a potent and selective oral inhibitor of menin-KMT2A interaction.Cost-effective and quality-assured.</p>Formule :C32H47FN6O4SDegré de pureté :99.12% - 99.74%Couleur et forme :SolidMasse moléculaire :630.82Ziftomenib
CAS :<p>Ziftomenib (KO-539) is an inhibitor of menin-MLL interaction with antitumor activity and can be used to study leukemia.</p>Formule :C33H42F3N9O2S2Degré de pureté :99.65%Couleur et forme :SolidMasse moléculaire :717.871Glucosamine
CAS :<p>Glucosamine (Chitosamine) is used as a dietary supplement. Glucosamine has pharmacological effects on osteoarthritis cartilage. High-Quality, Low-Cost!</p>Formule :C6H13NO5Degré de pureté :99.8% - 99.8%Couleur et forme :CoaMasse moléculaire :179.17Tilorone dihydrochloride
CAS :<p>Tilorone dihydrochloride is an orally active interferon inducer, and has antineoplastic and anti-inflammatory actions.</p>Formule :C25H36Cl2N2O3Degré de pureté :98% - 99.86%Couleur et forme :Orange Yellow Crystal PowderMasse moléculaire :483.47Ilginatinib hydrochloride
CAS :<p>Ilginatinib hydrochloride (NS-018 hydrochloride) is a highly active and orally bioavailable inhibitor of JAK2.</p>Formule :C21H21ClFN7Degré de pureté :99.55%Couleur et forme :SolidMasse moléculaire :425.89Citric acid trilithium salt tetrahydrate
CAS :<p>Citric acid trilithium salt tetrahydrate (Lithium citrate tribasic tetrahydrate) , the active component of Lithium, is a medicine used in the therapy of</p>Formule :C6H13Li3O11Degré de pureté :99.88%Couleur et forme :White Crystalline PowderMasse moléculaire :281.98Oltipraz
CAS :<p>Oltipraz (RP 35972) is a synthetic dithiolethione with potential chemopreventive and anti-angiogenic properties.</p>Formule :C8H6N2S3Degré de pureté :98.79% - 99.77%Couleur et forme :SolidMasse moléculaire :226.34T-3775440 hydrochloride
CAS :<p>T-3775440 hydrochloride is an irreversible inhibitor of lysine-specific histone demethylase (LSD1)(IC50 : 2.1 nM).</p>Formule :C18H23ClN4ODegré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :346.85BRM/BRG1 ATP Inhibitor-1
CAS :<p>BRM/BRG1 ATP Inhibitor-1 is an allosteric dual Brahma homolog (BRM)/SWI/SNF related matrix-associated actin-dependent regulator of chromatin subfamily A member</p>Formule :C11H9F3N4O2SDegré de pureté :98.17% - 99.84%Couleur et forme :SolidMasse moléculaire :318.27Delcasertib
CAS :<p>Delcasertib (KAI-9803) is a potent and selective inhibitor of δ-protein kinase C (δPKC).</p>Formule :C120H199N45O34S2Degré de pureté :99.96%Couleur et forme :SolidMasse moléculaire :2880.28Phenelzine sulfate
CAS :<p>Phenelzine sulfate is a non-selective and irreversible inhibitor of monoamine oxidase (MAOI), and with antidepressant and anxiolytic.</p>Formule :C8H14N2O4SDegré de pureté :98.38% - 99.83%Couleur et forme :SolidMasse moléculaire :234.27FIDAS-5
CAS :<p>FIDAS-5 is an orally active methionine adenosyltransferase 2A (MAT2A) inhibitor with an IC50 of 2.1 μM. Cost-effective and quality-assured.</p>Formule :C15H13ClFNDegré de pureté :97.66% - 98.3%Couleur et forme :SolidMasse moléculaire :261.72NI-42
CAS :<p>NI-42, a BRPFs inhibitor: IC50(BRPF1/2/3)=7.9/48/260 nM, Kd(BRPF1/2/3)=40/210/940 nM; selective for class IV BRDs.</p>Formule :C18H15N3O3SDegré de pureté :99.18%Couleur et forme :SolidMasse moléculaire :353.39Pulrodemstat benzenesulfonate
CAS :<p>Pulrodemstat benzenesulfonate (CC-90011 benzenesulfonate) is a potent and orally inhibitor of lysine specific demethylase-1 (LSD1) with anticancer effect.</p>Formule :C30H29F2N5O5SDegré de pureté :97.67%Couleur et forme :SolidMasse moléculaire :609.64Miglitol
CAS :<p>Miglitol (BAY1099) is an alpha-Glucosidase Inhibitor with antihyperglycemic activity.</p>Formule :C8H17NO5Degré de pureté :99.75% - 99.88%Couleur et forme :White To Pale-Yellow Powder SolidMasse moléculaire :207.22BMS-986158
CAS :<p>BMS-986158: BET inhibitor, IC50 of 6.6 nM in SCLC, 5 nM in TNBC cells.</p>Formule :C30H33N5O2Degré de pureté :98.78%Couleur et forme :SolidMasse moléculaire :495.62SJ10542
CAS :<p>SJ10542: potent JAK2/3-targeting PG-PROTAC; DC50s: JAK2 - 14 nM, JAK3 - 11 nM, JAK2-fusion ALL - 24 nM; CRBN recruiter.</p>Formule :C41H46N12O5SCouleur et forme :SolidMasse moléculaire :818.95Fluorescein-NAD+
<p>Fluorescein NAD+ is a non-radioactive PARP assay substrate, enabling direct enzyme measurement by fluorescence. Comes as 81μg in 250μl water.</p>Couleur et forme :SolidPROTAC HDAC6 degrader 4
<p>PROTAC HDAC6 degrader4 (Compound 17c) is a PROTAC that targets and degrades HDAC6, with a DC50 of 14 nM. It exhibits inhibitory activity against HDAC1, HDAC2, HDAC3, and HDAC6, with IC50 values of 2.2, 2.37, 0.61, and 0.295 μM, respectively. [Pink: ligand for target protein HDAC6 ligand-3; Black: linker; Blue: ligand for cereblon E3 ligase]</p>Formule :C39H42FN9O7Couleur et forme :SolidMasse moléculaire :767.81AUR1545
CAS :<p>AUR1545 is a selective KAT2A/KAT2B degradator exhibiting inhibitory activity against cancer models including AML, SCLC, and NEPC, and suppressing tumour growth in the NCI-H1048 xenograft model.</p>Formule :C41H50BrN9O5Degré de pureté :98.84%Couleur et forme :SolidMasse moléculaire :828.8ZL0590
CAS :<p>ZL0590 is an effective and selective inhibitor of BD1-BRD4 (IC50 = 90 nM) with anti-inflammatory activities.</p>Formule :C23H27F3N4O4SDegré de pureté :99.77%Couleur et forme :SoildMasse moléculaire :512.55PRMT3-IN-4
<p>PRMT3-IN-4 (intermediate 15) is an inhibitor of Protein arginine methyltransferase 3 (PRMT3) and serves as the active control for SGC707. It can be utilized in the synthesis of PROTACs targeting PRMT3 and is applicable in research related to leukemia.</p>Couleur et forme :Odour SolidCARM1/IKZF3 ligand 1
<p>CARM1/IKZF3 ligand 1 functions as an inhibitor of CARM1 and serves as a target protein ligand for the synthesis of PROTAC CARM1/IKZF3 degrader-1.</p>Formule :C27H35ClN6O3Couleur et forme :SolidMasse moléculaire :527.06CD532 hydrochloride
<p>CD532 hydrochloride, potent Aurora A inhibitor (IC50=45 nM), hampers MYCN protein, changes AURKA's shape, aids cancer research.</p>Couleur et forme :SolidKDM1A-IN-29
CAS :<p>KDM1A-IN-29 is a histone demethylase inhibitor.</p>Formule :C16H16ClN3O4SCouleur et forme :SoildMasse moléculaire :381.83UNC10142
<p>UNC10142 (Compound 44) is a small-molecule antagonist of CHD1, with a binding IC50 value of 1.7 μM. It induces a dose-dependent reduction in the viability of PTEN-deficient prostate cancer cells.</p>Formule :C33H52N6O3Couleur et forme :SolidMasse moléculaire :580.8DNA Damage & Repair Compound Library
<p>A unique collection of xnum DNA Damage &amp; Repair related compounds for high throughput screening (HTS) and high content screening (HCS);</p>Couleur et forme :Odour SolidSAMS
CAS :<p>SAMS peptide is a specific substrate for the AMP-activated protein kinase (AMPK).</p>Formule :C74H131N29O18S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1779.15NP213
CAS :<p>NP213 is a rapidly acting synthetic antimicrobial peptide (AMP).</p>Formule :C42H84N28O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1093.3Menin-KMT2A-IN-1
<p>Menin–KMT2A-IN-1 (Compound 20) is an inhibitor of menin–KMT2A, binding to menin with an IC50 of 8 nM, and disrupting the interaction between menin and lysine methyltransferase 2A (KMT2A). It inhibits hERG channels with an IC50 of 65 μM and suppresses MV4-11 cells with an IC50 of 74 nM. Furthermore, Menin–KMT2A-IN-1 exhibits favorable pharmacokinetic properties in CD-1 mice, with an oral bioavailability of 74%.</p>Formule :C28H35FN6O3Couleur et forme :SolidMasse moléculaire :522.61TCIP3
CAS :<p>TCIP3 is a bivalent molecular glue (molecular glue) that can simultaneously bind to both p300/CBP and BCL6. It redirects p300 and CBP to activate programmed cell death genes, which are typically repressed by the oncogenic driver BCL6. TCIP3 is useful for studying diffuse large B-cell lymphoma (DLBCL) and is not toxic to untransformed tonsil lymphocytes or fibroblasts.</p>Formule :C58H71ClF2N16O7Couleur et forme :SolidMasse moléculaire :1177.74HSP90/LSD1-IN-1
<p>HSP90/LSD1-IN-1 (compound 6) is a dual inhibitor of HSP90 and LSD1. This compound effectively inhibits the proliferation of prostate cancer cell lines PC-3 and DU145, with GI50 values of 0.24 μM and 0.30 μM, respectively.</p>Couleur et forme :Odour SolidHDAC1-IN-9
<p>HDAC1-IN-9 (13c) is an HDAC1 inhibitor. It inhibits the HDAC1 enzyme with an IC50 value of 1.07 µM. This compound exhibits the strongest antiproliferative activity against HT-29 (human colon adenocarcinoma cells), with an IC50 of 1.78 μM. In HCT-116 (human colon cancer cells), HDAC1-IN-9 significantly induces apoptosis. Additionally, HDAC1-IN-9 possesses antiangiogenic properties, reducing the expression levels of VEGFR-2 and phosphorylated VEGFR-2 (pVEGFR-2) by approximately 80%.</p>Formule :C17H17N3O3Couleur et forme :SolidMasse moléculaire :311.34Kinase Inhibitor Library
<p>A unique collection of 2720 kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;</p>Couleur et forme :Odour SolidPROTAC BRD4 Degrader-5
CAS :<p>PROTAC BRD4 Degrader-5 is a PROTAC that degrades BRD4 in HER2 positive and negative breast cancer cell lines.</p>Formule :C50H62ClN9O8S2Couleur et forme :SolidMasse moléculaire :1016.67Pumecitinib
CAS :<p>Pumecitinib is a Janus kinase (JAK) inhibitor. Pumecitinib exhibits anti-inflammatory activity.</p>Formule :C17H20N8O2SDegré de pureté :99.94%Couleur et forme :SoildMasse moléculaire :400.46Protein Kinase C (19-31)
CAS :<p>Protein Kinase C (19-31), a PKC inhibitor derived from PKCa, has a serine at position 25 and tests PKC activity.</p>Formule :C67H118N26O16Degré de pureté :98%Couleur et forme :Lyophilized PowderMasse moléculaire :1543.82Hyp-dBET1
<p>Hyp-dBET1 is a PROTAC degrader targeting BRD4, with an IC50 value of 3.4 μM in MDA-MB-231 cells. Under hypoxic conditions, Hyp-dBET1 becomes active, recruiting E3 ubiquitin ligase, and facilitates the degradation of BRD4 via the ubiquitin-proteasome system. Hyp-dBET1 is applicable in anti-cancer research.</p>Couleur et forme :Odour SolidTB22
<p>TB22 is a non-nucleoside inhibitor of DOT1LR231Q with anticancer activity. It inhibits the malignant phenotype of lung cancer cells harboring the R231Q mutation via the MAPK/ERK signaling pathway, making it useful for lung cancer research.</p>Couleur et forme :Odour SolidHDAC6-IN-53
<p>HDAC6-IN-53 (Compound W28) is an inhibitor targeting histone deacetylase 6 (HDAC6) with an IC50 of 19.65 nM. It reduces the idiopathic pulmonary fibrosis (IPF) phenotype by inhibiting TGF-β1-induced collagen expression and demonstrates therapeutic efficacy in a bleomycin-induced mouse model of pulmonary fibrosis. HDAC6-IN-53 is applicable for research in idiopathic pulmonary fibrosis and related pulmonary fibrotic diseases.</p>Couleur et forme :Odour SolidSMD-3236
CAS :<p>SMD-3236 is a PRAOTAC degrader targeting SMARCA2, designed using SMARCA ligand and VHL-1 ligand, and exhibits prolonged anti-tumor activity in vivo. SMARCA2 acts as a synthetic lethal target in cancer cells lacking SMARCA4, with SMD-3236 showing 2000-fold selectivity for SMARCA2 over SMARCA4, having a DC50 of less than 1 nM and a Dmax of over 95%. In the human cancer xenograft models deficient in SMARCA4, notably the H838 model, SMD-3236 effectively induces loss of SMARCA2 in tumor tissue while sparing the SMARCA4 protein, thereby inhibiting tumor growth. The compound consists of a target protein ligand (red part) SMI-1074, a PROTAC linker (black part) (trans-4-Ethynylcyclohexyl)methyl methanesulfonate, and an E3 ligase ligand (blue part) SMARCA2 ligand-14, forming the E3LigaseLigand-linker Conjugate 159.</p>Formule :C61H75ClN10O5SCouleur et forme :SolidMasse moléculaire :1095.83Uzansertib
CAS :<p>Uzansertib (INCB053914) is a potent pan-PIM kinase inhibitor with low IC50s: 0.24, 30, 0.12 nM for PIM1, 2, 3; hinders hematologic tumor growth.</p>Formule :C26H26F3N5O3Couleur et forme :SolidMasse moléculaire :513.51GSK8573
CAS :<p>GSK8573 is an inactive control compound for GSK2801. GSK8573 has binding activity to BRD9 (Kd of 1.04 μM).</p>Formule :C20H21NO3Degré de pureté :99.81%Couleur et forme :SolidMasse moléculaire :323.39PROTAC BRD4 Degrader-19
CAS :<p>PROTAC BRD4 Degrader-19 (compound 176) is a proteolysis-targeting chimera (PROTAC) designed to specifically degrade the BRD4 protein, offering potential utility</p>Formule :C44H38N8O5S2Couleur et forme :SolidMasse moléculaire :822.95BRD7-IN-1 free base
CAS :<p>BRD7-IN-1, a BI7273 derivative, transforms into PROTAC VZ185 (targets BRD7/9 with 4.5/1.8 nM DC50s) via a VHL linker.</p>Formule :C22H26N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :394.47GSK040
CAS :<p>GSK040: Potent BET BD2 inhibitor, pIC50 8.3, 5000x selectivity over BD1, for oncology & immunology research.</p>Formule :C29H34N4O4Couleur et forme :SolidMasse moléculaire :502.6SMD-3040 TFA
<p>SMD-3040 TFA is a selective SMARCA2 degrader comprising SMARCA2/4 ligands, a linker, and VHL ligands, utilized in PROTAC drug synthesis.</p>Degré de pureté :98%Couleur et forme :Odour SolidMNK/PIM-IN-1
CAS :<p>MNK/PIM-IN-1 is a novel dual inhibitor targeting both MNK and PIM pathways, characterized by its favorable pharmacokinetic profile.</p>Formule :C27H27FN6O2Couleur et forme :SolidMasse moléculaire :486.551Pim-1 kinase inhibitor 11
<p>Pim-1 kinase inhibitor 11 (10f) is an inhibitor of PIM-1 with an IC50 value of 0.18 μM. It exhibits anticancer activity by inducing apoptosis and causing cell cycle arrest.</p>Couleur et forme :Odour SolidMZP-54
CAS :<p>MZP-54 is a selective degrader of BRD3/4 based on PROTAC technology(Kd of 4 nM for Brd4BD2)</p>Formule :C55H66ClN7O9SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1036.67HIF-1 α (556-574)
CAS :<p>HIF-1 alpha (556-574) is a 19-mer fragment vital for gene expression in low oxygen; it binds VHL with critical proline 564 for stability.</p>Formule :C101H150D2N20O34S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2254.6CDD-1102 HCl
<p>CDD-1102 HCl is a novel BRDT-BD4 / BRD2-BD1302 selective inhibitor that shows non-hormonal contraceptive potential in ex vivo experiments.</p>Formule :C32H31ClN6O3Degré de pureté :98.30%Couleur et forme :SoildMasse moléculaire :583.08MNN-02-155
CAS :<p>MNN-02-155 is a bivalent molecular glue that can simultaneously interact with both p300/CBP and BCL6. It effectively induces the activation of BCL6-targeted reporter genes and promotes cell death. This compound is used in the research of diffuse large B-cell lymphoma (DLBCL).</p>Formule :C56H68ClF2N15O7Couleur et forme :SolidMasse moléculaire :1136.69CBP/p300-IN-8
CAS :<p>CBP/p300-IN-8 strongly inhibits CBP/P300 bromodomains; CBP IC50=0.01-0.1μM, BRD4 IC50=1-1000μM.</p>Formule :C27H31N3O4Couleur et forme :SolidMasse moléculaire :461.562HDAC11-IN-1
<p>HDAC11-IN-1 (Compound 14-NC6OH) is a macrocyclic inhibitor that selectively targets HDAC11 with a Ki of 40 nM. It demonstrates effective cell permeability and suppresses the expression of YAP1 and SOX2.</p>Formule :C43H63F3N6O6S2Couleur et forme :SolidMasse moléculaire :881.12Axl-IN-16
<p>Axl-IN-16, a dual Axl/HIF inhibitor, promotes Flammulina velutipes fruiting body formation and suppresses hypoxia-inducible factor activity along with receptor</p>Formule :C14H19ClO8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :350.75MS9024
<p>MS9024 is a degrader of DNA methyltransferase 1 (DNMT1), facilitating its degradation in HCT116 cells via the ubiquitin-proteasome pathway, with a DC50 of 35 nM (DC50 values are 254 nM in MDA-MB-468 and 101 nM in H1299). Additionally, MS9024 inhibits DNMT1 with an IC50 of 0.43 μM.</p>Couleur et forme :Odour SolidSNIPER(BRD)-1
CAS :<p>SNIPER(BRD)-1 has LCL-161, (+)-JQ1 linked; degrades BRD4, cIAP1/2, XIAP; IC50s: 6.8, 17, 49nM.</p>Formule :C53H66ClN9O8S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1056.73PRO-HD3
<p>PRO-HD3 is a cell-specific, PROTAC-based degrader targeting HDAC6 [1].</p>Degré de pureté :98%Couleur et forme :Odour SolidXF067-68
CAS :<p>XF067-68 is a PROTAC for targeted degradation of WD40 repeat domain protein 5 ( WDR5 )[1] .</p>Formule :C52H59F4N9O7SCouleur et forme :SolidMasse moléculaire :1030.14KB02-JQ1
CAS :<p>KB02-JQ1: potent BRD4-degrading PROTAC, stable, specific; doesn't affect BRD2/3, modifies DCAF16 for action.</p>Formule :C38H43Cl2N7O6SDegré de pureté :98%Couleur et forme :SoildMasse moléculaire :796.76Namoline
CAS :<p>Namoline, a γ-pyrone, inhibits LSD1 with a 51 μM IC50, blocking cell growth and showing potential in prostate cancer studies.</p>Formule :C10H3ClF3NO4Couleur et forme :SolidMasse moléculaire :293.58Lyngbyatoxin A
CAS :<p>Lyngbyatoxin A is an indole alkaloid from blue-green alga Lyngbya majuscula Gomont; responsible for dermatitis known as &quot;swimmers' itch&quot; in Hawaii.</p>Formule :C27H39N3O2Couleur et forme :SolidMasse moléculaire :437.62PROTAC BET degrader-3
<p>PROTAC BET Degrader-3 is a potent degrader OF BET based on PROTAC.</p>Formule :C53H64N12O9SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1045.22MS33
CAS :<p>MS33 degrades WDR5 protein, Kd 870 nM (VCB), 120 nM (WDR5); uses VHL ligase, aids acute myeloid leukemia study.</p>Formule :C64H84F3N11O7SCouleur et forme :SolidMasse moléculaire :1208.5Okicenone
CAS :<p>Okicenone is an antibiotic, interferring with HuR RNA binding, HuR trafficking, T-cell activation and cytokine expression.</p>Formule :C15H14O4Couleur et forme :SolidMasse moléculaire :258.27PROTAC SMARCA2/4-degrader-28
CAS :<p>PROTAC SMARCA2/4-degrader-28 (PROTAC 1) functions as a partial degrader of SMARCA2 and SMARCA4 through the PROTAC-based mechanism.</p>Formule :C54H68ClN9O11S2Couleur et forme :SolidMasse moléculaire :1118.75BAY-184
CAS :<p>BAY-184,KAT6A/B inhibitor (IC50=71/83 nM). Suppresses ERα activity. Impedes breast cancer proliferation.</p>Formule :C23H20N2O4SDegré de pureté :98.87%Couleur et forme :SolidMasse moléculaire :420.48Vanicoside A
CAS :<p>Vanicoside A is a protein kinase C( PKC ) inhibitor from Polygonum pensylvanicum [1] .</p>Formule :C51H50O21Couleur et forme :SolidMasse moléculaire :998.933β,6α,12β-Dammar-E-20(22)-ene-3,6,12,25-tetraol
CAS :<p>3β,6α,12β-Dammar-E-20(22)-ene-3,6,12,25-tetraol is a compound that functions as a SIRT1 activator, effectively enhancing SIRT1 activity.</p>Formule :C30H52O4Couleur et forme :SolidMasse moléculaire :476.742PROTAC BRD4 Degrader-10
CAS :<p>Compound 8b, a dual-ligand PROTAC, targets VHL & BRD4, degrades BRD4 in PC3 cells; conjugates with STEAP1/CLL1, DC50: 1.3/18 nM.</p>Formule :C59H71F2N9O15S4Couleur et forme :SolidMasse moléculaire :1312.5R 8605
CAS :<p>R 8605 is a third-generation retinoid.</p>Formule :C22H27NO4Couleur et forme :SolidMasse moléculaire :369.45GSK3735967
CAS :<p>GSK3735967: DNMT1 inhibitor, IC50 40 nM, dicyanopyridine core, binds hemimethylated CpG, interacts with H4K20me3.</p>Formule :C25H31N7OSCouleur et forme :SolidMasse moléculaire :477.62ZMF-23
<p>ZMF-23, a PAK1/HDAC6 dual inhibitor, suppresses PAK1 and HDAC6-mediated aerobic glycolysis and cellular migration while inducing TNF-α-regulated necroptosis and</p>Formule :C22H23Cl2N5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :476.36DS-103
<p>DS-103 is an HDAC inhibitor that targets HDAC1, HDAC2, HDAC3, HDAC6, and HDAC8 with IC50 values of 0.029, 0.123, 0.022, 0.367, and 9.26 μM, respectively. It also inhibits the malignant malaria parasite [Plasmodium falciparum 3D7] with an IC50 of 5.08 μM. In A2780 and Cal27 cells, DS-103 exhibits cytotoxicity with IC50 values of 1.48 μM and 1.47 μM, respectively, and reverses cisplatin resistance in these cells with IC50 values of 4.62 μM and 2.23 μM. DS-103 acts synergistically with cisplatin, enhancing apoptosis induced by cisplatin.</p>Formule :C28H33N5O3Couleur et forme :SolidMasse moléculaire :487.59HIV-1 protease-IN-10
<p>HIV-1 protease-IN-10 (Compound 2), exhibiting HIV-1 latency reversing activity (IC50: 0.22 μM), selectively binds to the PKCδ C1b domain (IC50: 0.69 μM) and</p>Formule :C23H40O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :396.56TAT-cyclo-CLLFVY
CAS :<p>Blocks HIF-1α/β dimerization, not HIF-2α; suppresses VEGF, CAIX in cancer cells; antiangiogenic in HUVECs (IC50 = 1.3 μM).</p>Formule :C111H188N42O24S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2559.1PROTAC BRD4 Degrader-13
CAS :<p>PROTAC BRD4 Degrader-13 targets VHL and BRD4, degrading BRD4 with DC50 of 0.025/6.0 nM in PC3 cells when linked to STEAP1/CLL1 antibodies.</p>Formule :C68H85F2N11O17P2S2Couleur et forme :SolidMasse moléculaire :1492.55Antidiabetic agent 7
<p>Antidiabetic agent 7 (Compound 5m) functions as a potent hyperglycemia inhibitor. It effectively stimulates GLUT4 translocation in skeletal muscle cells by activating the AMPK-dependent pathway. Additionally, this compound is capable of reducing blood glucose levels and exhibits favorable pharmacokinetic properties. Antidiabetic agent 7 is suitable for research related to antihyperglycemic treatments.</p>Formule :C27H21Cl2N5O3Couleur et forme :SolidMasse moléculaire :534.39Dihydrochlamydocin
CAS :<p>Dihydrochlamydocin, an inhibitor of histone deacetylases (HDAC), exhibits potent cytostatic activity against mastocytoma cells.</p>Formule :C28H40N4O6Couleur et forme :SolidMasse moléculaire :528.65UNC2399
CAS :<p>UNC2399, a biotinylated version of UNC1999, functions as a selective degrader of EZH2 and exhibits strong in vitro efficacy against EZH2, demonstrated by its IC</p>Formule :C67H104N10O17SCouleur et forme :SolidMasse moléculaire :1353.68AB3067
<p>AB3067 is a PROTAC degrader targeting BET protein, efficiently recruiting two distinct E3 ligases, Cereblon and VHL, with strong affinity (demonstrated by IC50 values of 559 nM for VHL and 190 nM for CRBN in vivo HEK293). It degrades BRD2, BRD3, BRD4, and CRBN with DC50 values of 2.1~2.3, 1.6, 15, and 75 nM, respectively. Additionally, AB3067 inhibits the proliferation of RKO cells, with an EC50 of 111 nM. (Pink: ligand for target protein; Black: linker; Blue: ligand for E3 ligase VHL and CRBN)</p>Formule :C74H91ClFN11O17S2Couleur et forme :SolidMasse moléculaire :1525.16Larsucosterol Ammonium salt
CAS :<p>Larsucosterol ammonium salt is a derivative of 25HC3S. It is a DNMT inhibitor, a LXR antagonist, an endogenous epigenetic modulator of lipid metabolism.</p>Formule :C27H49NO5SDegré de pureté :>99.99% - >99.99%Couleur et forme :SoildMasse moléculaire :499.75JAK-STAT Compound Library
<p>A unique collection of 252 JAK/STAT signaling targeted compounds for high throughput and high content screening;</p>Couleur et forme :Odour SolidCW-3308
<p>CW-3308 is an orally active PROTAC that targets BRD9. It is composed of the PROTAC target protein ligand Naphthyridin-Me-dimethoxybenzene-COOH, the linker 3-Azaspiro[5.5]undecane-9-methanol, and the E3 ubiquitin ligase ligand Thalidomide-methylpyrrolidine. The coupling of the E3 ubiquitin ligase ligand with the linker results in the conjugate Thalidomide-pyrrolidine-C-azaspiro.</p>Formule :C45H48N6O8Couleur et forme :SolidMasse moléculaire :800.9SW2_110A acetate
<p>SW2_110A acetate is a selective, cell-permeable chromobox inhibitor of homologue CBX8 (Kd = 800 nM) bound to CBX8 N-terminal color gamut (ChD).</p>Formule :C44H64N6O9Degré de pureté :98%Couleur et forme :SoildMasse moléculaire :821.01JQ-1 (carboxylic acid)-NH-C2-NH-AMPRO-222
<p>JQ-1 (carboxylic acid)-NH-C2-NH-AMPRO-222 incorporates a BRD4 ligand and a PROTAC linker, and is used in the synthesis of PROTAC BRD4 Degrader-29.</p>Formule :C43H51ClN8O3S2Couleur et forme :SolidMasse moléculaire :827.5Barasertib
CAS :<p>AZD1152 is a pro-drug of Barasertib (AZD1152)-hQPA. Which is a highly selective Aurora B inhibitor with IC50 of 0.37 nM in a cell-free assay.</p>Formule :C26H31FN7O6PDegré de pureté :99.63% - 99.92%Couleur et forme :SolidMasse moléculaire :587.54WDR5 ligand 2
CAS :<p>WDR5ligand 2 is a ligand for WDR5 and can be utilized in the synthesis of PROTAC WDR5degrader 1.</p>Formule :C29H31F3N4O4Couleur et forme :SolidMasse moléculaire :556.576PROTAC BRD4 Degrader-9
CAS :<p>PROTAC BRD4 Degrader-9 degrades BRD4 in PC3 cells; binds VHL and BRD4; DC50: STEAP1-0.86 nM, CLL1-7.6 nM.</p>Formule :C59H71F2N9O15S4Couleur et forme :SolidMasse moléculaire :1312.5BRD4 degrader-6
CAS :<p>BRD4 degrader-6 is a dimeric BDR4PROTAC class degrader with a DC50 of less than 0.1 μM. It effectively induces the ubiquitination and degradation of BDR4, exhibiting anticancer properties.</p>Formule :C61H71BClN9O7S2Couleur et forme :SolidMasse moléculaire :1152.67MS049 2HCl (1502816-23-0(free base))
<p>MS049 inhibits PRMT4 (IC50=34nM) & PRMT6 (IC50=43nM), less so for PRMT1, PRMT3, PRMT8, not others.</p>Formule :C15H26Cl2N2ODegré de pureté :99.9%Couleur et forme :SolidMasse moléculaire :321.28ZXH-3-26
CAS :<p>ZXH-3-26 is a PROTAC composed of a Cereblon ligand, an E3 ubiquitin ligase, and a BRD4 ligand that can be used to study cancer.</p>Formule :C38H37ClN8O7SDegré de pureté :98.90% - 98.90%Couleur et forme :SolidMasse moléculaire :785.27PRMT5-IN-12
CAS :<p>PRMT5-IN-12 shows remarkable inhibitory activity on PRMT5 .</p>Formule :C32H40N4O4Couleur et forme :SolidMasse moléculaire :544.696PI3Kα/HDAC6-IN-1
<p>PI3Kα/HDAC6-IN-1 (compound 21j) is a dual inhibitor of PI3Kα and HDAC6, exhibiting IC50 values of 2.9 nM and 26 nM, respectively.</p>Formule :C27H30F3N7O6S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :669.7Sirtuin modulator 5
CAS :<p>Sirtuin modulator 5 activates SIRT1 (<50 μM DC50), may extend cell lifespan, and could aid in researching various age/stress-related diseases.</p>Formule :C24H23N3O4Couleur et forme :SolidMasse moléculaire :417.46MAK-683 hydrochloride
CAS :<p>MAK683 hydrochloride is an inhibitor of embryonic ectoderm development (EED), with IC50 values of 59, 26nM measured in EED Alphascreen, ELISA.Cost-effective and quality-assured.</p>Formule :C20H18ClFN6ODegré de pureté :97.02% - >99.99%Couleur et forme :SolidMasse moléculaire :412.85GSK9311 hydrochloride
CAS :<p>GSK9311 hydrochloride is a less active GSK6853 analog, serving as a negative control, inhibiting BRPF1/2 (pIC50: 6.0/4.3).</p>Formule :C24H32ClN5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :474Thalidomide-NH-CBP/p300 ligand 2
CAS :<p>Thalidomide-NH-CBP/p300 ligand 2 (P-007) is a PROTAC-based compound designed to degrade CBP and p300, acting as a functional antagonist (WO2020173440).</p>Formule :C48H57F2N11O6Couleur et forme :SolidMasse moléculaire :922.052SR-0813
CAS :<p>SR-0813 is a potent and selective inhibitor of the YEATS domain in ENL/AF9.</p>Formule :C25H32N6O3SDegré de pureté :98.81%Couleur et forme :SolidMasse moléculaire :496.62KAT6-IN-2
<p>KAT6-IN-2 is a potent inhibitor of KAT6, showing promise for use in cancer research.</p>Couleur et forme :Odour SolidPROTAC BRD4 Degrader-30
<p>PROTACBRD4 degrader-30 is an ISOX-DUAL-based PROTAC degrader, targeting BRD4 with an IC50 value of 65 nM. It is used in research studies related to c-Myc oncoproteins and the pathophysiology of cancer cells.</p>Couleur et forme :Odour SolidAnemonin (6CI)
CAS :<p>Anemonin, a furanone dimer from Buttercups, may help manage melanocytes and osteoarthritis.</p>Formule :C10H8O4Couleur et forme :SolidMasse moléculaire :192.17GNE-987
CAS :<p>GNE-987 is a potent chimeric BET degrader, binding BRD4 BD1/BD2 at IC50: 4.7/4.4 nM & has a DC50: 0.03 nM in EOL-1 AML cells.</p>Formule :C56H67F2N9O8S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1096.31MRS2698
CAS :<p>MRS2698: potent P2Y2 agonist, EC50 8 nM, >300x selectivity over P2Y4/P2Y6.</p>Formule :C9H16N3O13P3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :499.22PROTAC SMARCA2/4-degrader-25
<p>PROTAC SMARCA2/4-degrader-25 is a PROTAC that targets SMARCA2/4. It consists of the E3 ligase ligand (2S,4R)-4-Hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide, a PROTAC Linker (S)-2-Amino-3,3-dimethylbutanoic acid, and the target protein ligand SMARCA2/4-ligand-3. The conjugate of the E3 ubiquitin ligase ligand and Linker is (S,R,S)-AHPC.</p>Formule :C44H50N10O9S2Couleur et forme :SolidMasse moléculaire :927.06PF-04577806
CAS :<p>PF-04577806: potent & selective PKC inhibitor, ATP competitive, blocks PKCα/βI/βII/γ/θ (IC50: 2.4-45.9 nM), may reverse diabetic retinal leakage.</p>Formule :C26H37N7O3Couleur et forme :SolidMasse moléculaire :495.628JB300
CAS :<p>JB300 is a PROTAC-based compound that serves as a highly selective degrader of Aurora A, with a DC50 of 30 nM. It is utilized in cancer research. JB300 comprises the PROTAC target protein ligand MK-5108 [pink part], E3 ligase ligand Thalidomide-O-COOH [blue part], and PROTAC Linker Boc-NH-PEG2-C2-NH2 [black part]. The conjugate of the E3 ubiquitin ligase ligand and linker is Thalidomide-O-COOH-NH2-C2-PEG2-NH-Boc.</p>Formule :C43H45ClFN7O10SCouleur et forme :SolidMasse moléculaire :906.375EXQ-2d
<p>EXQ-2d is an inhibitor of tankyrase, effectively targeting TNKS1 and TNKS2 with IC50 values of 48.8 nM and 13.8 nM (pIC50=7.31 and 7.86), respectively. Additionally, EXQ-2d suppresses the WNT/β-catenin signaling pathway with an IC50 of 515 nM. It demonstrates antiproliferative activity in cancer cells COLO 320DM and RKO, with GI50 values of 4.9 μM and 77 μM, respectively.</p>Formule :C18H17N3O3Couleur et forme :SolidMasse moléculaire :323.35
