Chromatine/Épigénétique
Les inhibiteurs de la chromatine/épigénétique sont des composés qui modulent la structure et la fonction de la chromatine ou interfèrent avec les modifications épigénétiques, telles que la méthylation de l'ADN et la modification des histones. Ces inhibiteurs sont des outils essentiels pour étudier la régulation de l'expression génique et le rôle de l'épigénétique dans des maladies telles que le cancer, les troubles neurologiques et les anomalies du développement. En ciblant les processus épigénétiques, ces inhibiteurs peuvent modifier les schémas d'expression génique et offrir de nouvelles perspectives thérapeutiques. Chez CymitQuimica, nous offrons une large sélection d'inhibiteurs de la chromatine/épigénétique de haute qualité pour soutenir vos recherches en biologie moléculaire, génétique et épigénétique.
Sous-catégories appartenant à la catégorie "Chromatine/Épigénétique"
2615 produits trouvés pour "Chromatine/Épigénétique"
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DNMT2-IN-2
DNMT2-IN-2 is a selective inhibitor of DNA methyltransferase 2 (DNMT2) with a KD value of 3.04 μM. It targets a concealed allosteric binding site of DNMT2 and reduces m5C levels in tRNA of MOLM-13 cells. This compound works synergistically with Doxorubicin to impair cell viability and is applicable in cancer research, including studies of cervical cancer and leukemia.Couleur et forme :Odour SolidPBRM1-BD2-IN-5
CAS :PBRM1-BD2-IN-5 is a potent inhibitor of the PBRM1 Bromodomain, demonstrating dissociation constant (Kd) values of 1.5 μM and 3.9 μM for PBRM1-BD2 and PBRM1-BD5Formule :C15H13ClN2ODegré de pureté :99.51%Couleur et forme :SoildMasse moléculaire :272.73Ref: TM-T60159
1mg84,00€1mL*10mM (DMSO)170,00€5mg177,00€10mg260,00€25mg429,00€50mg572,00€100mg793,00€200mg1.063,00€dBRD9
CAS :dBRD9 is a PROTAC.Formule :C40H45N7O10Degré de pureté :99.81%Couleur et forme :SolidMasse moléculaire :783.83Ref: TM-T31221
1mg129,00€5mg311,00€1mL*10mM (DMSO)434,00€10mg502,00€25mg874,00€50mg1.320,00€100mg1.833,00€coumarin-SAHA
CAS :SAHA inhibits class I/II HDAC; c-SAHA, a fluorescent derivative, excites at 325 nm and emits at 400 nm.Formule :C18H22N2O5Couleur et forme :SolidMasse moléculaire :346.383PROTAC BET Degrader-1
CAS :PROTAC BET Degrader-1 is a potent degrader of BET based on PROTAC.Formule :C44H45N11O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :871.9SETD7-IN-1
SETD7-IN-1 (compound 7), a PFI-2 analogue, acts as both a substrate and inhibitor of histone lysine methyltransferase SETD7, exhibiting an inhibitoryDegré de pureté :98%Couleur et forme :Odour SolidPROTAC BRD4 Degrader-9
CAS :PROTAC BRD4 Degrader-9 degrades BRD4 in PC3 cells; binds VHL and BRD4; DC50: STEAP1-0.86 nM, CLL1-7.6 nM.Formule :C59H71F2N9O15S4Couleur et forme :SolidMasse moléculaire :1312.5CDD-1102 HCl
CDD-1102 HCl is a novel BRDT-BD4 / BRD2-BD1302 selective inhibitor that shows non-hormonal contraceptive potential in ex vivo experiments.Formule :C32H31ClN6O3Degré de pureté :98.30%Couleur et forme :SoildMasse moléculaire :583.08ZXH-3-26
CAS :ZXH-3-26 is a PROTAC composed of a Cereblon ligand, an E3 ubiquitin ligase, and a BRD4 ligand that can be used to study cancer.Formule :C38H37ClN8O7SDegré de pureté :98.90% - 98.90%Couleur et forme :SolidMasse moléculaire :785.27PROTAC BET Degrader-13
PROTACBET Degrader-13 (Compound 34) is a TRIM21-based PROTAC (TRIMTAC) degrader that targets BET proteins. It effectively degrades the PML-eGFP-BRD4 fusion protein, causing a near-complete loss of EGFP+ nuclear foci with an EC50 of 1.4 μM.Couleur et forme :Odour SolidiRucaparib-AP6
CAS :iRucaparib-AP6: a specific, non-trapping PARP1 degrader; inhibits the enzyme's activity and scaffolding.Formule :C46H55FN6O11Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :886.96PRMT5-IN-12
CAS :PRMT5-IN-12 shows remarkable inhibitory activity on PRMT5 .Formule :C32H40N4O4Couleur et forme :SolidMasse moléculaire :544.696PI3Kα/HDAC6-IN-1
PI3Kα/HDAC6-IN-1 (compound 21j) is a dual inhibitor of PI3Kα and HDAC6, exhibiting IC50 values of 2.9 nM and 26 nM, respectively.Formule :C27H30F3N7O6S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :669.7HDAC3/BRD4-IN-1
HDAC3/BRD4-IN-1 (compound 26n) is an inhibitor of HDAC3/BRD4, exhibiting an IC50 of 8 nM for HDAC3, while its IC50 values for HDAC1 and HDAC2 are 220 nM and 120 nM, respectively. It displays anti-tumor and anti-proliferative effects by upregulating Ac-H3 and downregulating c-Myc. The half-life of HDAC3/BRD4-IN-1 in human liver microsomes is 29.36 minutes.Formule :C31H35N5O4Couleur et forme :SolidMasse moléculaire :541.64SMD-3236
CAS :SMD-3236 is a PRAOTAC degrader targeting SMARCA2, designed using SMARCA ligand and VHL-1 ligand, and exhibits prolonged anti-tumor activity in vivo. SMARCA2 acts as a synthetic lethal target in cancer cells lacking SMARCA4, with SMD-3236 showing 2000-fold selectivity for SMARCA2 over SMARCA4, having a DC50 of less than 1 nM and a Dmax of over 95%. In the human cancer xenograft models deficient in SMARCA4, notably the H838 model, SMD-3236 effectively induces loss of SMARCA2 in tumor tissue while sparing the SMARCA4 protein, thereby inhibiting tumor growth. The compound consists of a target protein ligand (red part) SMI-1074, a PROTAC linker (black part) (trans-4-Ethynylcyclohexyl)methyl methanesulfonate, and an E3 ligase ligand (blue part) SMARCA2 ligand-14, forming the E3LigaseLigand-linker Conjugate 159.Formule :C61H75ClN10O5SCouleur et forme :SolidMasse moléculaire :1095.83PROTAC BRD4 Degrader-20
CAS :PROTAC BRD4 Degrader-20 (compound 195) is a bifunctional degrader of BRD4 [1].Formule :C55H58ClN9O7S2Couleur et forme :SolidMasse moléculaire :1056.69HIV-1 protease-IN-10
HIV-1 protease-IN-10 (Compound 2), exhibiting HIV-1 latency reversing activity (IC50: 0.22 μM), selectively binds to the PKCδ C1b domain (IC50: 0.69 μM) andFormule :C23H40O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :396.56SK2187
CAS :SK2187 is a selective degrader of AURKAPROTAC with a DC50 of approximately 10 nM. It exhibits growth-inhibitory effects on NGP cells, with an IC50 value of 101.5 nM. SK2187 is utilized in studies of MYCN-amplified neuroblastoma.Formule :C45H49ClFN7O11SCouleur et forme :SolidMasse moléculaire :950.43HDAC6/HSP90-IN-3
HDAC6/HSP90-IN-3 is an orally active dual inhibitor of histone deacetylase 6 (HDAC6) and heat shock protein 90 (HSP90), with IC50 values of 28 nM and 0.88 μM, respectively. This compound shows potential for use in research on malignant tumors such as prostate cancer.Couleur et forme :Odour SolidZifcasiran
CAS :Zifcasiran reduces HIF synthesis, has antitumor properties, useful in renal carcinoma studies.Formule :C737H972F20N211O349P43S8Couleur et forme :SolidMasse moléculaire :20339.13TAT-cyclo-CLLFVY
CAS :Blocks HIF-1α/β dimerization, not HIF-2α; suppresses VEGF, CAIX in cancer cells; antiangiogenic in HUVECs (IC50 = 1.3 μM).Formule :C111H188N42O24S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2559.1Go6976
CAS :Go6976 is a PKC inhibitor, widely used in research to probe PKC functions in health and disease.Formule :C24H18N4ODegré de pureté :95.89%Couleur et forme :Off-White To Yellow SolidMasse moléculaire :378.43MACTIDE-V
MACTIDE-V is an orally active and selective peptide-drug conjugate targeting CD206. This compound delivers Verteporfin to CD206+ tumor-associated macrophages (TAM), thereby inhibiting the YAP/TAZ signaling pathway. It facilitates YAP exclusion from the nucleus, induces TAM polarization toward an anti-tumor phenotype, enhances phagocytosis and antigen presentation, and promotes T cell infiltration and NK cell activity. MACTIDE-V suppresses primary tumor growth and lung metastasis in triple-negative breast cancer (TNBC) mouse models.Formule :C109H156N22O27S2Couleur et forme :SolidMasse moléculaire :2269.09517Sirtuin modulator 5
CAS :Sirtuin modulator 5 activates SIRT1 (<50 μM DC50), may extend cell lifespan, and could aid in researching various age/stress-related diseases.Formule :C24H23N3O4Couleur et forme :SolidMasse moléculaire :417.46ZMF-23
ZMF-23, a PAK1/HDAC6 dual inhibitor, suppresses PAK1 and HDAC6-mediated aerobic glycolysis and cellular migration while inducing TNF-α-regulated necroptosis andFormule :C22H23Cl2N5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :476.36JWZ-7-7-Neg1
CAS :JWZ-7-7-Neg1, a neighboring transcription chemical inducer (TCIP), serves as a negative control. It exhibits reduced binding capabilities to BRD4 or BCL6 compared to JWZ-7-7, resulting in lower cytotoxicity towards DLBCL cells.Formule :C50H58Cl2N12O6SCouleur et forme :SolidMasse moléculaire :1026.04PROTAC BET Degrader-10
CAS :PROTAC BET Degrader-10 targets and degrades BRD4 with a DC50 of 49 nM, using Cereblon ligands.Formule :C39H39ClN8O6SCouleur et forme :SolidMasse moléculaire :783.3Ref: TM-T39374
200mgÀ demander500mgÀ demander5mg225,00€1mL*10mM (DMSO)309,00€10mg359,00€25mg672,00€50mg999,00€100mg1.485,00€GSK097
CAS :GSK097: Potent, selective BD2 inhibitor in BET proteins; 2000x more selective for BD2 than BD1; soluble >1 mg/mL in FaSSIF.Formule :C19H21N3O3Couleur et forme :SolidMasse moléculaire :339.395HDAC1-IN-9
HDAC1-IN-9 (13c) is an HDAC1 inhibitor. It inhibits the HDAC1 enzyme with an IC50 value of 1.07 µM. This compound exhibits the strongest antiproliferative activity against HT-29 (human colon adenocarcinoma cells), with an IC50 of 1.78 μM. In HCT-116 (human colon cancer cells), HDAC1-IN-9 significantly induces apoptosis. Additionally, HDAC1-IN-9 possesses antiangiogenic properties, reducing the expression levels of VEGFR-2 and phosphorylated VEGFR-2 (pVEGFR-2) by approximately 80%.Formule :C17H17N3O3Couleur et forme :SolidMasse moléculaire :311.34Echinomycin
CAS :Echinomycin (Quinomycin A) is a quinoxaline antibiotic and a DNA-intercalating peptide that inhibits hypoxia-inducible factor-1 (HIF-1) DNA binding activity.Formule :C51H64N12O12S2Degré de pureté :95%Couleur et forme :SolidMasse moléculaire :1101.26SJ46420
SJ46420, a potent and selective precursor variant of SJ46421, functions as a BRD3 PROTAC degrader through a KLHDC2-dependent mechanism. This compound specifically degrades BRD3, which concurrently results in the partial reduction of BRD2 or BRD4 levels.Formule :C43H43ClN8O5S2Couleur et forme :SolidMasse moléculaire :851.44Axltide
CAS :Axltide mimics mouse Insulin receptor substrate 1, amino acids 979-989 with sequence KKSRGDYMTMQIG.Formule :C63H107N19O20S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1514.77UNC10013
UNC10013 is an allosteric modulator of SETDB1, exhibiting negative allosteric regulation through covalent bond formation with Cys385 on the 3TD domain. It has a kinact/KI value of 1.0 × 10^6 M^-1*s^-1. UNC10013 effectively disrupts SETDB1-mediated Akt methylation, holding potential for application in cancer and neurodegenerative disease research.Couleur et forme :Odour SolidMalantide TFA
Malantide TFA: synthetic dodecapeptide, PKA-specific with Km 15 μM, >90% PKI blockage, also PKC substrate, Km 16 μM.Formule :C74H125F3N22O23Couleur et forme :SolidMasse moléculaire :1747.917-Hydroxyneolamellarin A
CAS :7-Hydroxyneolamellarin A, from Dendrilla nigra, inhibits HIF-1α and VEGF in cancer research.Formule :C24H19NO5Couleur et forme :SolidMasse moléculaire :401.41M-1211
CAS :M 1121 is a covalent and orally active inhibitor of the menin-MLL interaction capable of achieving complete and persistent tumor regression.Formule :C42H57FN6O6SCouleur et forme :SolidMasse moléculaire :793.01EZH2-IN-5
CAS :EZH2-IN-5, potent EZH2 inhibitor; IC50: 1.52 nM (wild-type), 4.07 nM (Tyr641 mutant).Formule :C26H37BrN4O2Couleur et forme :SolidMasse moléculaire :517.512NSD2-IN-4
NSD2-IN-4 is a potent, selective inhibitor of the NSD2-SET domain, showing promise for the treatment of diseases related to NSD2 [1].Formule :C18H14ClN3O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :355.78TO-1187 TFA
TO-1187 TFA is a selective HDAC6 PROTAC degrader with a DC50 of 5.81 nM. It facilitates the ubiquitination and degradation of HDAC6 and is applicable to research in hematologic malignancies and solid tumors.Couleur et forme :Odour SolidProtein Kinase C (19-35) Peptide
CAS :PKC (19-35) Peptide inhibits PKC by blocking its substrate-binding, rendering cytoplasmic PKC inactive.Formule :C89H153N33O22Couleur et forme :SolidMasse moléculaire :2037.4YDR1
CAS :YDR1 is an effective PROTAC degrader of SMARCA2, featuring a DC50 value of 7.7 nM.Formule :C44H49FN10O5Couleur et forme :SolidMasse moléculaire :816.92N,N-Didesethyl Sunitinib
CAS :N,N-Didesethyl Sunitinib Hydrochloride is a potent AMPK inhibitor with IC50 of 393 nM and 141 nM for AMPKα1 and AMPK2,respectively.Formule :C18H19FN4O2Degré de pureté :97.73%Couleur et forme :SoildMasse moléculaire :342.37Ref: TM-T60128
1mg130,00€5mg313,00€1mL*10mM (DMSO)319,00€10mg439,00€25mg713,00€50mg973,00€100mg1.333,00€GSK3735967
CAS :GSK3735967: DNMT1 inhibitor, IC50 40 nM, dicyanopyridine core, binds hemimethylated CpG, interacts with H4K20me3.Formule :C25H31N7OSCouleur et forme :SolidMasse moléculaire :477.62PRMT5-IN-14
CAS :PRMT5-IN-14 is a PRMT5 inhibitor to treat cancer, sickle cell, and hereditary persistence of foetal hemoglobin (HPFH) mutations.Formule :C18H18Cl2N4O4Couleur et forme :SolidMasse moléculaire :425.27PROTAC BRD4 Degrader-13
CAS :PROTAC BRD4 Degrader-13 targets VHL and BRD4, degrading BRD4 with DC50 of 0.025/6.0 nM in PC3 cells when linked to STEAP1/CLL1 antibodies.Formule :C68H85F2N11O17P2S2Couleur et forme :SolidMasse moléculaire :1492.55PROTAC HDAC6 degrader 2
PROTAC HDAC6 degrader 2 (Compound 1) is an HDAC6 PROTAC degrader with an IC50 value of 0.643 μM. It facilitates the ubiquitination and degradation of HDAC6 and is applicable in research on hematological and solid cancers.Formule :C34H33F2N9O8Couleur et forme :SolidMasse moléculaire :733.678MD6a
MD6a is a melatonin derivative with inhibitory activity against poly(ADP-ribose) polymerase (PARP-1). It maintains protein homeostasis and improves mitochondrial function via the TOR/HSF-1 signaling pathway, providing neuroprotective effects.Formule :C21H22N2O2Masse moléculaire :334.16813SIRT3 activator 2
SIRT3 activator2 (compound 2a) acts as an activator of SIRT3. It is presumed to bind directly with SIRT3 in SH-SY5Y cells, as inferred through thermal stability, facilitating the SIRT3-dependent clearance of α-Syn. Furthermore, SIRT3 activator2 enhances motor functions in Parkinsonian mice and dose-dependently prevents the loss of dopaminergic (DA) neurons in the substantia nigra.Formule :C22H24N2O9SCouleur et forme :SolidMasse moléculaire :492.5MZP-54
CAS :MZP-54 is a selective degrader of BRD3/4 based on PROTAC technology(Kd of 4 nM for Brd4BD2)Formule :C55H66ClN7O9SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1036.67PROTAC BRM degrader-1
CAS :PROTAC BRM degrader-1 (compound 17) serves as a PROTAC-based degrader targeting both BRM and BRG1, exhibiting DC50 values of 93 pM and 4.9 nM, respectively [1].Formule :C57H69N11O8SCouleur et forme :SolidMasse moléculaire :1068.29PROTAC BRD4 Degrader-38
PROTACBRD4 Degrader-38 is a BRD4 PROTAC degrader with DC50 values of 86 nM and 106 nM for the short and long BRD4 isoforms, respectively. It significantly induces BRD4 degradation through covalent binding at the C232 site of the E3 ligase TRIM28.Couleur et forme :Odour SolidCPI-268456
CAS :CPI-268456 is a compound which has bioactive.Formule :C20H15Cl2N3O2Couleur et forme :SolidMasse moléculaire :400.26Myelin Basic Protein
CAS :Myelin basic protein (MBP) is a protein believed to be important in the process of myelination of nerves in the nervous system.Formule :C60H103N21O17Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1390.59BET-IN-17
BET-IN-17, also known as compound 16, serves as a pan-inhibitor for BET, exhibiting inhibitory potencies (pIC50) of 7.8 for BET BD1 and 7.6 for BET BD2 [1].Formule :C30H36N4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :484.63AS-254s
AS-254s is an inhibitor of absent, small, or homeotic-like 1 protein (ASH1L), with an IC50 of 94 nM (FP assay). It exhibits antiproliferative activity against leukemia cells with MLL1 rearrangement, with a GI50 of less than 1 μM. Additionally, AS-254s can induce differentiation in MLL1-r leukemia cells.Formule :C36H41ClN6O3S2Couleur et forme :SolidMasse moléculaire :705.332BB-Cl-Amidine TFA
BB-Cl-Amidine (TFA) is an inhibitor of peptidylarginine deiminase (PAD).Couleur et forme :Odour Solid[Ala9,10, Lys11,12] Glycogen Synthase (1-12)
CAS :[Ala9,10, Lys11,12] Glycogen Synthase (1-12): PKC's selective phosphorylation substrate, used to assess PKC activity. [1]Formule :C56H103N17O16Couleur et forme :SolidMasse moléculaire :1270.52TNKS-2-IN-2
CAS :TNKS-2-IN-2 is a TNKS2 selective inhibitor (IC50: 22 nM) with potential anti-tumour activity for the study of colon cancer lung cancer and breast cancer.Formule :C26H23N3O6Degré de pureté :99.45%Couleur et forme :SoildMasse moléculaire :473.48MS049 2HCl (1502816-23-0(free base))
MS049 inhibits PRMT4 (IC50=34nM) & PRMT6 (IC50=43nM), less so for PRMT1, PRMT3, PRMT8, not others.Formule :C15H26Cl2N2ODegré de pureté :99.9%Couleur et forme :SolidMasse moléculaire :321.28PCAF-IN-1
CAS :PCAF-IN-1 is a highly selective PCAF inhibitor with potential anti-tumor, anti-inflammatory, and anti-heart disease effects.Formule :C15H11ClN6Couleur et forme :SolidMasse moléculaire :310.74KDM4-IN-3
CAS :KDM4-IN-3 is a KDM4 inhibitor that is cell-permeable and kills prostate cancer cells at low micromolar concentrations.Formule :C17H14N4OCouleur et forme :SolidMasse moléculaire :290.32CHZ868
CAS :CHZ868 is a type II JAK inhibitor with potential antitumor activity that reverses the persistence of type I JAK inhibitors and can be used to study leukemia.Formule :C22H19F2N5O2Degré de pureté :99.38%Couleur et forme :SolidMasse moléculaire :423.42EM127
CAS :EM127: covalent SMYD3 inhibitor, KD 13μM, impedes ERK1/2, hinders SMYD3 gene regulation, long-term methyltransferase reduction, potential in cancer study.Formule :C14H18ClN3O3Degré de pureté :97.55%Couleur et forme :SolidMasse moléculaire :311.76INO-1001
CAS :INO-1001: potent PARP inhibitor with antitumor properties, enhances radiosensitivity & radiation-induced cell death.Formule :C23H25N3O4SCouleur et forme :SolidMasse moléculaire :439.53N-Descyclopropanecarbaldehyde Olaparib
CAS :N-Descyclopropanecarbaldehyde Olaparib is a CRBN ligand for dual EGFR/PARP PROTAC, suitable for F-18 radiolabeling and tumor imaging via PET.Formule :C20H19FN4O2Couleur et forme :SolidMasse moléculaire :366.39SIRT-IN-3
CAS :SIRT-IN-3: potent SIRT1 inhibitor (IC50=17μM), 4x selective over SIRT2, 14x over SIRT3 (IC50s: 74μM & 235μM).Formule :C13H12N2OCouleur et forme :SolidMasse moléculaire :212.25AS-85
CAS :AS-85 is an ASH1L inhibitor with anti-leukemic activity that inhibits leukemic cell growth and increases cLogP.Formule :C26H28F3N5O3S2Degré de pureté :98.96%Couleur et forme :SolidMasse moléculaire :579.66EZM0414 TFA
CAS :EZM0414 TFA (SETD2-IN-1 TFA) is a SETD2 inhibitor with anticancer and antiproliferative effects for the study of leukemia and immune dysfunction.Formule :C24H30F4N4O4Degré de pureté :98.88%Couleur et forme :SolidMasse moléculaire :514.51Fenbendazole-d3
CAS :Fenbendazole-d3 is a deuterated compound of Fenbendazole. Fenbendazole has a CAS number of 43210-67-9. Fenbendazole is an antinematodal benzimidazole used in veterinary medicine.Formule :C15H10D3N3O2SCouleur et forme :SolidMasse moléculaire :302.37(R)-HH2853
CAS :(R)-HH2853, a mutant EZH2 inhibitor, IC50 <100 nM for EZH2-Y641F, targets cancer/autoimmune diseases.Formule :C31H36F3N7O3Degré de pureté :97.53% - 98.85%Couleur et forme :SolidMasse moléculaire :611.66MI-3454
CAS :MI-3454: potent, oral menin-MLL1 inhibitor, IC50 of 0.51 nM, halts leukemia cells, aids remission in mice.Formule :C32H35F3N8OSDegré de pureté :99.68%Couleur et forme :SolidMasse moléculaire :636.73PARP1 Protein, Human, Recombinant (His)
PARP Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag.Degré de pureté :94.1%Couleur et forme :Lyophilized PowderMasse moléculaire :114.5 kDa (predicted); 100-110 kDa (reducing conditions)PARP Protein, Mouse, Recombinant (His)
PARP Protein, Mouse, Recombinant (His) is expressed in Baculovirus insect cells with His tag.Couleur et forme :Lyophilized PowderMasse moléculaire :115 kDa (predicted); 75 kDa (reducing conditions)EHMT2-IN-1
CAS :EHMT2-IN-1: potent EHMT inhibitor, for blood disorders/cancer research; IC50s <100 nM for EHMT1/2 peptides and cellular EHMT2.Formule :C18H23N7OCouleur et forme :SolidMasse moléculaire :353.42PROTAC EZH2 Degrader-1
CAS :PROTAC EZH2 Degrader-1 suppresses EZH2 methyltransferase activity with IC50 2.7 nM, serving as a potent tool in cancer research and EZH2 inhibition studies.Formule :C54H67N7O8Couleur et forme :SolidMasse moléculaire :942.15Itacitinib adipate
CAS :Itacitinib adipate: oral JAK1 inhibitor, tested in phase II myelofibrosis trial.Formule :C32H33F4N9O5Couleur et forme :SolidMasse moléculaire :699.66MC4171
MC4171 is a selective KAT8 inhibitor with antiproliferative activity and can be used to study cancer.Formule :C21H15N3O3Degré de pureté :99.56%Couleur et forme :SolidMasse moléculaire :357.36(R)-GSK-3685032
CAS :(R)-GSK-3685032 is a selective, reversible DNMT1 inhibitor, non-covalent, IC50: 0.036 μM; reduces DNA methylation, inhibits cancer growth.Formule :C22H24N6OSCouleur et forme :SolidMasse moléculaire :420.54Boc-Lys(Ac)-AMC
CAS :Boc-Lys(Ac)-AMC (Boc-L-Lys(Ac)-AMC) is a synthetic substrate coupled to an HDAC-specific fluorophore (Ex/Em = 355 nm/460 nm).Formule :C23H31N3O6Degré de pureté :99.87%Couleur et forme :SolidMasse moléculaire :445.51Ref: TM-T36578
5mg51,00€1mL*10mM (DMSO)52,00€10mg77,00€25mg129,00€50mg182,00€100mg268,00€200mg387,00€KDM4C-IN-1
CAS :KDM4C-IN-1 is aKDM4C inhibitor withial anticancer activity.KDM4C-IN-1 inhibits the growth of HepG2 and A549 cells, and can be used for the study of leukaemia.Formule :C15H14N4O3Degré de pureté :99.33%Couleur et forme :SolidMasse moléculaire :298.3PROTAC PARP1 degrader
CAS :PROTAC PARP1 degrader suppresses MDA-MB-231 cells at 10 μM, IC50: 6.12 μM in 24h.Formule :C58H63Cl2N11O10Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1145.1DTP3
CAS :DTP3 is a selective MKK7/GADD45β inhibitor, which inhibits cancer-selective NF-κB survival pathway.Formule :C26H35N7O5Couleur et forme :SolidMasse moléculaire :525.6Ilunocitinib
CAS :Ilunocitinib is a non-selective and orally active Janus kinase (JAK) inhibitor for pruritus and atopic dermatitis caused by atopic dermatitis in dogs.Formule :C17H17N7O2SDegré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :383.43Ref: TM-T38571
1mg92,00€5mg230,00€1mL*10mM (DMSO)251,00€10mg356,00€25mg713,00€50mg1.189,00€100mg1.791,00€200mg2.412,00€GSK778
CAS :GSK778 selectively inhibits BD1 bromodomains (BRD2, BRD3, BRD4, BRDT) and impedes cell growth, causing arrest and apoptosis.Formule :C30H33N5O3Degré de pureté :98.42%Couleur et forme :SolidMasse moléculaire :511.61Ref: TM-T9703
1mL*10mM (DMSO)44,00€1mg152,00€5mg295,00€10mg477,00€25mg954,00€50mg1.513,00€100mg2.097,00€TPOP146
CAS :TPOP146 is a selective CBP/P300 benzoxazepine bromodomain inhibitor (Kd: 134 nM and 5.02 μM for CBP and BRD4).Formule :C27H35N3O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :481.58Eicosapentaenoic Acid (Standard)
CAS :Eicosapentaenoic Acid (Standard) is the standard substance of Eicosapentaenoic Acid, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Eicosapentaenoic Acid is an ω-3 fatty acid and an inhibitor of fatty acid synthase (FASN). Eicosapentaenoic Acid promotes DNA demethylation in the reexpression of the tumor suppressor gene CCAAT/ enhancer-binding protein δ (C/EBPδ). Eicosapentaenoic Acid activates the RAS/ERK/C/EBPβ pathway in U937 leukemia cells through demethylation of the CpG island of H-RAS intron 1. Eicosapentaenoic Acid promotes the relaxation of vascular smooth muscle cells and vasodilation.Formule :C20H30O2Couleur et forme :LiquidMasse moléculaire :302.45JET-209
JET-209 is a potent proteolysis-targeting chimera (PROTAC) that effectively degrades CBP/p300, exhibiting half-maximal degradation concentration (DC50) valuesFormule :C46H47N9O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :821.92Atinvicitinib
CAS :Atinvicitinib, a selective JAK1 inhibitor, blocks cytokine signaling, modulating itch, allergy, and inflammatory responses, immune and therapeutic studies.Formule :C16H17FN6O3Degré de pureté :99.36%Couleur et forme :SolidMasse moléculaire :360.35Ref: TM-T39646
1mg138,00€1mL*10mM (DMSO)264,00€5mg334,00€10mg550,00€25mg1.063,00€50mg1.738,00€100mg2.547,00€2'-Deoxy-2'-fluoro-β-D-arabinocytidine hydrochloride
CAS :2'-Deoxy-2'-fluoro-beta-D-arabinocytidine HCl inhibits DNA methyltransferase with potential anti-tumor properties.Formule :C9H13ClFN3O4Degré de pureté :99.43%Couleur et forme :SolidMasse moléculaire :281.671,4-DPCA ethyl ester
CAS :1,4-DPCA ethyl ester is a form of 1,4-DPCA modified, which has potential anticancer activity based on growth inhibition assays with the mlh1 rad18 yeast strain.Formule :C15H12N2O3Degré de pureté :99.54%Couleur et forme :SolidMasse moléculaire :268.27Ref: TM-T36796
2mg37,00€5mg54,00€1mL*10mM (DMSO)59,00€10mg90,00€25mg157,00€50mg256,00€100mg434,00€200mg623,00€CX-6258 hydrochloride hydrate
CAS :CX-6258 hydrochloride hydrate is a potent and selective inhibitor of pan-Pim kinase that acts on Pim-1 (IC50: 5 nM), Pim-2 (IC50: 25 nM) and Pim-3 (IC50: 16 nMFormule :C26H27Cl2N3O4Couleur et forme :SolidMasse moléculaire :516.42(2R)-Octyl-α-hydroxyglutarate
CAS :(2R)-Octyl-α-hydroxyglutarate ((2R)-Octyl-2-HG) is a D-isomer 2-Hydroxyglutarate modified form.Formule :C13H24O5Couleur et forme :SolidMasse moléculaire :260.33Pim-1/2 kinase inhibitor 1
CAS :Orally active Pim-1/2 inhibitor blocks kinase phosphorylation; used in prostate cancer research.Formule :C11H9NO3SDegré de pureté :99.78%Couleur et forme :SolidMasse moléculaire :235.26Ifidancitinib
CAS :Ifidancitinib (ATI-50002) is a JAK kinase 1/3 inhibitor used to study autoimmune diseases.Formule :C20H18FN5O3Degré de pureté :98.05%Couleur et forme :SolidMasse moléculaire :395.39GSK-J2
CAS :GSK-J2 is an inactive enantiomer of GSK-J1 that is lipophilic and serves as an inactive control for GSK-J21.Formule :C22H23N5O2Degré de pureté :97.55%Couleur et forme :SolidMasse moléculaire :389.45Ref: TM-T11476
1mg34,00€5mg71,00€10mg92,00€1mL*10mM (DMSO)101,00€25mg157,00€50mg222,00€100mg329,00€200mg487,00€SGC-iMLLT
CAS :SGC-iMLLT is a potent and selective MLLT1/3-histone interactions inhibitor(IC50 = 0.26 μM),and is a first-in-class chemical probe displaying cellular targetFormule :C22H24N6ODegré de pureté :99.21% - 99.92%Couleur et forme :SolidMasse moléculaire :388.47MS8511 hydrochloride
CAS :MS8511 hydrochloride is a selective G9a/GLP inhibitor with IC50 values of 100 nM and 140 nM respectively, exhibiting covalent and irreversible characteristics.Formule :C28H42ClN5O3Couleur et forme :SolidMasse moléculaire :532.12GSK9311
CAS :GSK9311 inhibits BRPF bromodomain (pIC50: 6.0 and 4.3 for BRPF1 and BRPF2, respectively).Formule :C24H31N5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :437.53T-448
CAS :T-448 is a lysine-specific demethylase 1 inhibitor (IC50: 22 nM) that improves learning function in mice.T-448 can be used to study memory deficits.Formule :C19H22N4O3SDegré de pureté :97% - 98.63%Couleur et forme :SolidMasse moléculaire :386.47O6BTG-octylglucoside
CAS :O6BTG-octylglucoside is a potent O6-methylguanine-DNAmethyl-transferase (MGMT) inhibitor (IC50s: 10 nM and 32 nM in HeLa S3 cells and in vitro (cell extracts)).Formule :C24H34BrN5O7SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :616.53ADTL-SA1215
CAS :ADTL-SA1215 is a SIRT3 activator with SIRT3 deacetylase activity for the study of triple negative breast cancer.Formule :C26H29I2NO3Degré de pureté :99.23%Couleur et forme :SolidMasse moléculaire :657.32GSK2879552
CAS :GSK2879552: oral, irreversible LSD1 inhibitor with potential cancer-fighting properties.Formule :C23H28N2O2Degré de pureté :99.22%Couleur et forme :SolidMasse moléculaire :364.48DA-3003-1
CAS :DA-3003-1 (NSC 663284) is a Cdc25 dual specificity phosphatase inhibitor with antitumor activity and inhibits Cdc25B2, Cdc25A, Cdc25B2, and Cdc25C.Formule :C15H16ClN3O3Degré de pureté :99.27% - 99.79%Couleur et forme :SolidMasse moléculaire :321.76PR5-LL-CM01
CAS :PR5-LL-CM01 is a novel protein arginine methyltransferase 5 (PRMT5) inhibitor in colorectal and pancreatic cancers.Formule :C23H27N7Couleur et forme :SolidMasse moléculaire :401.51BAY-850
CAS :BAY-850 is ainhibitor of adenosine triphosphatase family protein 2 that inhibits ovarian cancer growth and metastasis in in vitro and in vivo models.Formule :C38H44ClN5O3Degré de pureté :98% - 98%Couleur et forme :SolidMasse moléculaire :654.24I-BET567
CAS :I-BET567: potent, oral pan-BET inhibitor; pIC50s: 6.9 (BRD4 BD1), 7.2 (BD2); effective in mouse cancer and inflammation models.Formule :C17H18ClN5O2Degré de pureté :99.8%Couleur et forme :SolidMasse moléculaire :359.81Ref: TM-T9619
1mg89,00€5mg187,00€1mL*10mM (DMSO)205,00€10mg286,00€25mg575,00€50mg863,00€100mg1.269,00€PKC-θ inhibitor
CAS :PKC-theta inhibitor is PKC-θinhibitor, with an IC50 of 12 nM.Formule :C20H25F3N6O3Degré de pureté :99.46%Couleur et forme :SolidMasse moléculaire :454.45Ref: TM-T5423
1mg101,00€5mg236,00€1mL*10mM (DMSO)259,00€10mg313,00€25mg442,00€50mg580,00€100mg893,00€200mg1.198,00€HDAC-IN-4
CAS :HDAC-IN-4 is a selective HDAC6 and HDAC10 inhibitor (pIC50s: 7.2 and 6.8 in BRET assay) with antitumoral activity.Formule :C20H21N3O2Couleur et forme :SolidMasse moléculaire :335.4SIRT5 inhibitor 3
CAS :SIRT5 inhibitor 3 is potent and competitive by inhibiting SIRT5 deacetylation, with potential in metabolic, cancer, neurodegenerative, cardiovascular .Formule :C22H12FN3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :401.35Protein kinase inhibitor H-7 dihydrochloride
CAS :Protein kinase inhibitor H-7 dihydrochloride(H-7 dihydrochloride) is a potent protein kinase C (PKC) inhibitor.Formule :C14H19Cl2N3O2SDegré de pureté :99.81%Couleur et forme :White Crystalline SolidMasse moléculaire :364.29Anti-PARP1 Antibody (8I163)
Anti-PARP1 Antibody (8I163) is a Mouse antibody targeting PARP1. Anti-PARP1 Antibody (8I163) can be used in IHC-P.Couleur et forme :Odour LiquidAnti-PARP Antibody (1W26)
Anti-PARP Antibody (1W26) is a Mouse antibody targeting PARP. Anti-PARP Antibody (1W26) can be used in WB,IHC-P,IP.Couleur et forme :Odour LiquidAnti-PARP1 Antibody (6I459)
Anti-PARP1 Antibody (6I459) is an antibody targeting PARP1. Anti-PARP1 Antibody (6I459) can be used in ELISA, IHC.Couleur et forme :Odour LiquidAnti-PARP1 Antibody (7A800)
Anti-PARP1 Antibody (7A800) is an antibody targeting PARP1. Anti-PARP1 Antibody (7A800) can be used in ELISA, WB, IHC.Couleur et forme :Odour LiquidAnti-PARP1 Antibody (9E313)
Anti-PARP1 Antibody (9E313) is a Mouse antibody targeting PARP1. Anti-PARP1 Antibody (9E313) can be used in IHC-P.Couleur et forme :Odour LiquidNSC 694621
CAS :NSC 694621 is a PCAF inhibitor that forms a covalent bond with Cys574, irreversibly inhibiting its acetyltransferase activity, inhibit proliferation,anticancer.Formule :C13H10N2O2SDegré de pureté :99.7%Couleur et forme :SolidMasse moléculaire :258.3Anti-PARP1 Antibody (8S756)
Anti-PARP1 Antibody (8S756) is an antibody targeting PARP1. Anti-PARP1 Antibody (8S756) can be used in ELISA, WB, IHC, IF, FCM.Couleur et forme :Odour LiquidGintemetostat
CAS :Gintemetostat (KTX-1001) is a potent NSD2 inhibitor (IC50=0.001-0.01μM) for treating NSD2-dysregulated cancers.Formule :C25H26F4N8O2Couleur et forme :SolidMasse moléculaire :546.52(±)-1,2-Diolein
CAS :(±)-1,2-Diolein (1,2-Dioleoyl-rac-glycerol) (1,2-Dioleoyl-rac-glycerol) is a PKC activator. (±)-1,2-Diolein could increases myotubes Ca 2+ influx.Formule :C39H72O5Couleur et forme :SolidMasse moléculaire :620.997-Chloro-4-(piperazin-1-yl)quinoline
CAS :7-Cl-4-(piperazin-1-yl)quinolone: sirtuin inhibitor, serotonin uptake blocker, antimalarial (D10 IC50 1.18µM, K1 IC50 0.97µM).Formule :C13H14ClN3Degré de pureté :99.52%Couleur et forme :Light Yellow SolidMasse moléculaire :247.72AMI-1 free acid
CAS :AMI-1: Potent reversible PRMT inhibitor; IC50: 8.8 μM (hPRMT1), 3.0 μM (yeast-Hmt1p); blocks substrate binding.
Formule :C21H16N2O9S2Degré de pureté :97.8%Couleur et forme :SolidMasse moléculaire :504.49AZ505 ditrifluoroacetate
CAS :AZ505 ditrifluoroacetate is an effective and selective SMYD2 inhibitor (IC50: 0.12 μM).Formule :C33H40Cl2F6N4O8Couleur et forme :SolidMasse moléculaire :805.59XY1
CAS :XY1 is a very close analogue of SGC707 (a potent, selective, and non-competitive inhibitor of PRMT3 with IC50 of 31 nM), It is intended to be used as aFormule :C17H19N3O2Degré de pureté :97.74% - 99%Couleur et forme :SolidMasse moléculaire :297.35AZ960
CAS :AZ960 is an effective ATP competitive JAK2 inhibitor (IC50/Ki: <3 nM and0.45 nM).Formule :C18H16F2N6Degré de pureté :96.02% - 99.88%Couleur et forme :SolidMasse moléculaire :354.364-(3-Chlorophenyl)-2(3H)-thiazolone
CAS :4-(3-chlorophenyl)-2,3-dihydro-1,3-thiazol-2-one: a thiazole used to make antifungals, antivirals, and anti-inflammatories.Formule :C9H6ClNOSDegré de pureté :95.311%Couleur et forme :SolidMasse moléculaire :211.67UNC0379
CAS :UNC0379 is a selective, substrate-competitive inhibitor of the lysine methyltransferase SETD8.Formule :C23H35N5O2Degré de pureté :94.41% - 99.97%Couleur et forme :SolidMasse moléculaire :413.56WP1066
CAS :WP1066 is a inhibitor of JAK2 (IC50: 2.30 μM) and STAT3 (IC50: 2.43 μM) in HEL cells; shows activity to JAK2, STAT3/5, and ERK1/2, not JAK1 and JAK3.Formule :C17H14BrN3ODegré de pureté :98.92% - 99.73%Couleur et forme :SolidMasse moléculaire :356.22SGC707
CAS :SGC707 is a potent, selective, and cell-active allosteric inhibitor of PRMT3.Formule :C16H18N4O2Degré de pureté :99.75% - 99.89%Couleur et forme :SolidMasse moléculaire :298.34BI-7273
CAS :BI-7273 is an effective, specific, BRD9 BD Inhibitor, which can infiltrate cell.Formule :C20H23N3O3Degré de pureté :97.37% - 99.57%Couleur et forme :SolidMasse moléculaire :353.41TCS PIM-1 1
CAS :TCS PIM-1 1 (SC 204330) is a potent ATP-competitive inhibitor of Pim-1 kinase with an IC50 of 50 nM, selective over MEK1/2 and Pim-2.Formule :C18H11BrN2O2Degré de pureté :97% - 97.98%Couleur et forme :SolidMasse moléculaire :367.2Ref: TM-T2253
1mg34,00€5mg60,00€1mL*10mM (DMSO)92,00€10mg94,00€25mg177,00€50mg269,00€100mg401,00€200mg580,00€Aurothiomalate sodium
CAS :Sodium aurothiomalate (Miochrysin) inhibits PKC-ι, TrxR; used as an anti-rheumatic and has anti-tumor properties.Formule :C4H3AuNa2O4SDegré de pureté :99.66%Couleur et forme :SoildMasse moléculaire :390.07Rucaparib monocamsylate
CAS :Rucaparib monocamsylate (Rucaparib Camsylate) is a PARP inhibitor. Rucaparib Camsylate also displays binding affinity to eight other PARP domains.Formule :C29H34FN3O5SDegré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :555.665-Ph-IAA
CAS :5-Ph-IAA is a derivative of Indole-3-acetic acid (IAA), which is a plant hormone and acts as an enzyme or prodrug combination for cancer gene therapy.Formule :C16H13NO2Degré de pureté :99.37% - 99.973%Couleur et forme :SolidMasse moléculaire :251.28PI-1840
CAS :PI-1840 is a reversible and selective chymotrypsin-like (CT-L) inhibitor, with little proteasome proteolytic effects on trypsin-like (T-L) and PGPH-L.Formule :C22H26N4O3Degré de pureté :98.82%Couleur et forme :SolidMasse moléculaire :394.47GSK-J1 sodium salt
CAS :GSK-J1 sodium salt is a potent inhibitor of the H3K27 histone demethylases JMJD3 and UTX.Formule :C22H22N5NaO2Couleur et forme :SolidMasse moléculaire :411.4408CBP/EP300-IN-1
CAS :CBP/EP300-IN-1 is a CBP/EP300 bromodomain inhibitor.Formule :C23H23FN2O5Degré de pureté :99.05%Couleur et forme :SolidMasse moléculaire :426.44Ref: TM-T7264
1mg46,00€2mg62,00€5mg92,00€1mL*10mM (DMSO)100,00€10mg152,00€25mg250,00€50mg353,00€100mg502,00€200mg682,00€Ro 31-8220
CAS :Ro 31-8220: potent PKC inhibitor (IC50: 5-27 nM). Affects MAPKAP-K1b, MSK1, S6K1, GSK3β (IC50: 3-38 nM), not MKK3/4/6/7.Formule :C25H23N5O2SCouleur et forme :SolidMasse moléculaire :457.55Niraparib hydrochloride
CAS :Niraparib hydrochloride (MK-4827) is a PARP inhibitor with potential cancer treatment effects, causing DNA damage and apoptosis.Formule :C19H21ClN4ODegré de pureté :99.26%Couleur et forme :SolidMasse moléculaire :356.85B2
CAS :B2 (Linazolamide intermediate B impurity 2) promotes inclusion formation in cellular models of Huntington's disease and Parkinson's diseaseFormule :C20H17ClN4O3Degré de pureté :99.66%Couleur et forme :SolidMasse moléculaire :396.83Buformin hydrochloride
CAS :Buformin hydrochloride, an oral biguanide antidiabetic, activates AMPK, enhances insulin sensitivity, and inhibits hepatic glucose production.Formule :C6H16ClN5Degré de pureté :97.83%Couleur et forme :SolidMasse moléculaire :193.68C-7280948
CAS :C-7280948 is a PRMT1 inhibitor.Formule :C14H16N2O2SDegré de pureté :99.55% - ≥95%Couleur et forme :SolidMasse moléculaire :276.35Ref: TM-T2097
5mg46,00€1mL*10mM (DMSO)49,00€10mg66,00€25mg109,00€50mg178,00€100mg268,00€200mg414,00€500mg667,00€AZD1208
CAS :AZD1208 is a novel, orally bioavailable, highly selective PIM kinase inhibitor with single nanomolar potency against all three PIM kinases.
Formule :C21H21N3O2SDegré de pureté :97.24% - 99.83%Couleur et forme :SolidMasse moléculaire :379.48Birabresib
CAS :Birabresib (MK-8628) is a synthetic, small molecule inhibitor of the BET (Bromodomain and Extra-Terminal) family of bromodomain-containing proteins 2, 3 and 4Formule :C25H22ClN5O2SDegré de pureté :98.3% - 99.36%Couleur et forme :SolidMasse moléculaire :491.99Ref: TM-T6032
2mg46,00€5mg70,00€1mL*10mM (DMSO)74,00€10mg90,00€25mg142,00€50mg222,00€100mg375,00€200mg560,00€500mg893,00€NSC 228155
CAS :NSC 228155 is an activator of EGFR, binding to the sEGFR dimerization domain II and modulate EGFR tyrosine phosphorylation.Formule :C11H6N4O4SDegré de pureté :99.84%Couleur et forme :SolidMasse moléculaire :290.25Ref: TM-T6908
2mg34,00€5mg48,00€1mL*10mM (DMSO)50,00€10mg63,00€25mg117,00€50mg178,00€100mg334,00€200mg469,00€Aurora kinase inhibitor-3
CAS :Aurora kinase inhibitor-3 (Aurora Kinase Inhibitor III) is a potent inhibitor of Aurora A kinase (IC50 = 42 nM).1 It is selective for Aurora A over BMX, BTK,Formule :C21H18F3N5ODegré de pureté :98.91%Couleur et forme :SolidMasse moléculaire :413.4Ref: TM-T5524
1mg66,00€2mg89,00€5mg152,00€1mL*10mM (DMSO)167,00€10mg236,00€25mg401,00€50mg580,00€100mg797,00€200mg1.099,00€653-47
CAS :653-47 enhances the effects of 666-15 on inhibiting CREB and is a mild CREB inhibitor itself (IC50: 26.3μM).Formule :C20H19ClN2O3Couleur et forme :SolidMasse moléculaire :370.83SNS-314
CAS :SNS-314 inhibits Aurora kinases A and B, blocking cell division in AK-overexpressing tumors.Formule :C18H15ClN6OS2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :430.93Izilendustat hydrochloride
CAS :Izilendustat hydrochloride inhibits prolyl hydroxylase, stabilizing HIF-1α/HIF-2, with potential to treat various HIF-1α diseases.Formule :C22H29Cl2N3O4Couleur et forme :SolidMasse moléculaire :470.39MI-503
CAS :MI-503 is an efficient and selective Menin-MLL inhibitor. MI-503 has a significant inhibitory effect on human MLL leukemia cell line. Cost-effective and quality-assured.Formule :C28H27F3N8SDegré de pureté :99.87% - 99.99%Couleur et forme :SolidMasse moléculaire :564.63Ref: TM-TQ0069
1mg50,00€5mg114,00€1mL*10mM (DMSO)141,00€10mg178,00€25mg334,00€50mg557,00€100mg888,00€PF-CBP1
CAS :PF-CBP1 HCl is a highly selective inhibitor of the bromodomain of CREB-binding protein(CREBBP).Formule :C29H36N4O3Degré de pureté :99.45%Couleur et forme :SolidMasse moléculaire :488.62Ritlecitinib
CAS :Ritlecitinib (PF-06651600) is an orally available, selective JAK3 inhibitor and does not affect the activity of JAK1/2.Cost-effective and quality-assured.Formule :C15H19N5ODegré de pureté :98.82% - 99.92%Couleur et forme :SolidMasse moléculaire :285.34Ref: TM-T5382
2mg37,00€5mg52,00€1mL*10mM (DMSO)73,00€10mg90,00€25mg205,00€50mg290,00€100mg408,00€200mg595,00€6-Bromo-3-methyl-1,4-dihydroquinazolin-2-one
CAS :CHEMBRDG-BB 7118966 is an inhibitor of Bromodomain-containing protein 4 (human).Formule :C9H9BrN2ODegré de pureté :99.28%Couleur et forme :SolidMasse moléculaire :241.08Ref: TM-T8609
1mg58,00€1mL*10mM (DMSO)107,00€5mg116,00€10mg172,00€25mg281,00€50mg396,00€100mg537,00€200mg712,00€WZ4003
CAS :WZ4003, a highly selective NUAK kinase inhibitor, is with IC50 of 20 nM and 100 nM for NUAK1 and NUAK2, respectively.Formule :C25H29ClN6O3Degré de pureté :99.65% - >99.99%Couleur et forme :SolidMasse moléculaire :496.99Ref: TM-T6291
5mg48,00€1mL*10mM (DMSO)50,00€10mg73,00€25mg111,00€50mg166,00€100mg241,00€200mg358,00€500mg590,00€I-CBP112
CAS :I-CBP112 is a specific and potent acetyl-lysine competitive protein-protein interaction inhibitor targeting the CBP/p300 bromodomains.Formule :C27H36N2O5Degré de pureté :98.18%Couleur et forme :SolidMasse moléculaire :468.59Ref: TM-T3969
1mg33,00€2mg50,00€5mg92,00€1mL*10mM (DMSO)92,00€10mg161,00€25mg296,00€50mg425,00€100mg583,00€200mg785,00€Paris saponin VII
CAS :Paris saponin VII (Dioscini) shows inhibitory effects on cell proliferation.Formule :C51H82O21Degré de pureté :99.51% - 99.63%Couleur et forme :SolidMasse moléculaire :1031.18Amifostine sodium
CAS :Amifostine sodium is a phosphorothioate proposed as a radiation-protective agent. It causes splenic vasodilation and may block autonomic ganglia.Formule :C5H15N2NaO3PSCouleur et forme :SolidMasse moléculaire :237.21CM-579 trihydrochloride
CM-579 trihydrochloride: reversible G9a/DNMT inhibitor with IC50s 16 nM (G9a) & 32 nM (DNMT); potent against various cancer cells.Formule :C29H43Cl3N4O3Couleur et forme :SolidMasse moléculaire :602.04NU1025
CAS :NU1025 (NSC-696807) is a potent PARP inhibitor with IC50 of 400 nM.Formule :C9H8N2O2Degré de pureté :99.86%Couleur et forme :SolidMasse moléculaire :176.17Ref: TM-T6912
2mg46,00€5mg67,00€1mL*10mM (DMSO)67,00€10mg98,00€25mg178,00€50mg301,00€100mg475,00€500mg1.063,00€ZINC13466751
CAS :ZINC13466751 is a potent HIF-1α/von Hippel-Lindau interaction inhibitor(IC50 = 2.0 µM).Formule :C20H21N5O2Degré de pureté :99.8%Couleur et forme :SolidMasse moléculaire :363.41UNC1079
CAS :UNC1079 is an selective L3MBTL3 domain inhibitor
Formule :C28H42N4O2Degré de pureté :99.48%Couleur et forme :SolidMasse moléculaire :466.66Senaparib
CAS :Senaparib (IMP4297) is a novel highly potent and selective oral PARP1/2 inhibitor with strong antitumor activity.Formule :C24H20F2N6O3Degré de pureté :99.8%Couleur et forme :SolidMasse moléculaire :478.45Ref: TM-T9593
1mg46,00€2mg59,00€5mg87,00€1mL*10mM (DMSO)96,00€10mg153,00€25mg274,00€50mg432,00€100mg638,00€A-769662
CAS :A-769662 is an effective, reversible AMPK activator(EC50=0.8 μM).Formule :C20H12N2O3SDegré de pureté :97.52% - 99.58%Couleur et forme :SolidMasse moléculaire :360.39Ref: TM-T2468
2mg37,00€5mg54,00€1mL*10mM (DMSO)56,00€10mg74,00€25mg135,00€50mg244,00€100mg440,00€500mg964,00€BAZ1A-IN-1
CAS :BAZ1A-IN-1, a potent inhibitor, KD 0.52 μM against BAZ1A, is effective in high-BAZ1A cancer cells, not in low-BAZ1A ones.Formule :C16H12N4O3SDegré de pureté :99.87%Couleur et forme :SolidMasse moléculaire :340.36Ref: TM-T9552
1mg84,00€5mg177,00€1mL*10mM (DMSO)195,00€10mg268,00€25mg537,00€50mg803,00€100mg1.099,00€200mg1.468,00€A1874
CAS :A1874 is a nutlin-based and BRD4-degrading PROTAC which induces BRD4 degradation in cells. Effective in inhibiting many cancer cell lines proliferation.
Formule :C58H62Cl3F2N9O7SDegré de pureté :99.52%Couleur et forme :SolidMasse moléculaire :1173.59M1001
CAS :M1001 is a HIF-2α agonist.Formule :C17H17N3O2SDegré de pureté :98.83%Couleur et forme :SolidMasse moléculaire :327.4Cucurbitacin I
CAS :Cucurbitacin I (JSI-124), a natural compound, is a selective inhibitor of JAK2/STAT3 with anti-cancer activity.Formule :C30H42O7Degré de pureté :96.69% - 99.8%Couleur et forme :SolidMasse moléculaire :514.65KDM4D-IN-1
CAS :KDM4D-IN-1 is a KDM4D inhibitor (IC50: 0.41±0.03 μM).Formule :C11H7N5ODegré de pureté :99.51% - >99.99%Couleur et forme :SolidMasse moléculaire :225.21Ref: TM-T4214
1mg73,00€5mg158,00€1mL*10mM (DMSO)168,00€10mg245,00€25mg495,00€50mg795,00€100mg1.161,00€JNJ-7706621
CAS :JNJ-7706621 is a potent aurora kinase inhibitor, and also inhibits CDK1 and CDK2.Formule :C15H12F2N6O3SDegré de pureté :99.1% - 99.85%Couleur et forme :SolidMasse moléculaire :394.36Ref: TM-T6126
1mg48,00€1mL*10mM (DMSO)94,00€5mg100,00€10mg155,00€25mg268,00€50mg432,00€100mg595,00€200mg833,00€MR837
CAS :MR837 (NSD2-PWWP1 antagonist 3f) is a NSD2-PWWP1 antagonist.Formule :C16H14N2OSDegré de pureté :99.77% - 99.85%Couleur et forme :SolidMasse moléculaire :282.36Ref: TM-T8879
2mg38,00€5mg55,00€1mL*10mM (DMSO)66,00€10mg92,00€25mg138,00€50mg243,00€100mg355,00€200mg502,00€Apabetalone
CAS :Apabetalone (RVX000222) , an effective BET bromodomain inhibitor, has been investigated for the treatment of diabetes, atherosclerosis, and coronary arteryFormule :C20H22N2O5Degré de pureté :98.08% - ≥98%Couleur et forme :SolidMasse moléculaire :370.4PF 477736
CAS :PF 477736 (PF-736,PF-00477736) is a specifc, effective and ATP-competitive Chk1 inhibitor (Ki: 0.49 nM ) and also inhibits FGFR3, Aurora-A, VEGFR2, Flt3, Fms (Formule :C22H25N7O2Degré de pureté :97.58% - 99.94%Couleur et forme :SolidMasse moléculaire :419.48BRD4 Inhibitor-24
CAS :BRD4 Inhibitor-24 is a BRD4 small molecule inhibitor with antitumor activity.Formule :C13H14N2O4Degré de pureté :99.66%Couleur et forme :SolidMasse moléculaire :262.26BI-9564
CAS :BI-9564, a specific cell-permeable BRD9 BD inhibitor. The Kd for BRD9 is 5.9 nM, and IC50 for BET family is > 100 μM.
Formule :C20H23N3O3Degré de pureté :99.38%Couleur et forme :SolidMasse moléculaire :353.41EPZ015666
CAS :EPZ015666 (GSK3235025) is an orally available inhibitor of PRMT5 enzymatic activity.Formule :C20H25N5O3Degré de pureté :98% - 99.64%Couleur et forme :SolidMasse moléculaire :383.44CPI-455
CAS :CPI-455 is a specific KDM5 inhibitor.Formule :C16H14N4ODegré de pureté :97.87% - 99.03%Couleur et forme :SolidMasse moléculaire :278.31Ref: TM-T3552
1mg34,00€2mg49,00€5mg70,00€1mL*10mM (DMSO)70,00€10mg105,00€25mg178,00€50mg335,00€100mg505,00€MK-8617
CAS :MK-8617 is an orally available HIF PHD1 3 pan-inhibitor, inhibiting PHD1/2/3 (IC50: 1.0/1.0/14 nM).Formule :C24H21N5O4Degré de pureté :99.38% - >99.99%Couleur et forme :SolidMasse moléculaire :443.45MI-463
CAS :MI-463 is a potent and orally bioavailable inhibitor of the menin-mLL interaction (IC50: 15.3 nM).Formule :C24H23F3N6SDegré de pureté :99.18% - >99.99%Couleur et forme :SolidMasse moléculaire :484.54ASP4132
CAS :ASP4132 is an orally active AMPK activator (EC50 : 18 nM), has anti-cancer activity.Formule :C46H51F3N6O8S2Degré de pureté :98.34%Couleur et forme :SolidMasse moléculaire :937.06Ref: TM-T8432
1mg50,00€5mg114,00€10mg177,00€1mL*10mM (DMSO)185,00€25mg321,00€50mg482,00€100mg677,00€200mg928,00€LLY-507
CAS :LLY-507 is an effective, cell-active, and specific inhibitor of protein-lysine Methyltransferase SMYD2.Formule :C36H42N6ODegré de pureté :99.58% - 99.93%Couleur et forme :SolidMasse moléculaire :574.76Ref: TM-T6879
1mg42,00€2mg52,00€5mg80,00€1mL*10mM (DMSO)104,00€10mg131,00€25mg289,00€50mg522,00€100mg747,00€PF-06409577
CAS :PF-06409577 is an effective, orally active, and specific allosteric activator of AMPK (EC50: 7 nM, for α1β1γ1).Formule :C19H16ClNO3Degré de pureté :95.17% - 98.21%Couleur et forme :SolidMasse moléculaire :341.79Ref: TM-T4427
1mg34,00€2mg43,00€5mg63,00€1mL*10mM (DMSO)71,00€10mg100,00€25mg200,00€50mg334,00€100mg537,00€200mg762,00€Delgocitinib EtOH
CAS :Delgocitinib (LEO-124249/JTE052) is a selective JAK inhibitor used for reducing skin inflammation and treating chronic dermatitis.Formule :C18H24N6O2Couleur et forme :SolidMasse moléculaire :356.433,6-Dihydroxyflavone
CAS :3,6-Dihydroxyflavone suppresses the epithelial-mesenchymal transition in breast cancer cells by inhibiting the Notch signaling pathway.Formule :C15H10O4Degré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :254.24SETDB1-TTD-IN-1 TFA
SETDB1-TTD-IN-1 TFA: potent, selective SETDB1-TTD inhibitor (Kd: 88 nM), useful for related biological research.Formule :C30H32F3N5O4Couleur et forme :SolidMasse moléculaire :583.6Piribedil hydrochloride
CAS :Piribedil HCl treats Parkinson's, circulatory issues, aids cancer research; inhibits MLL1; D2/D3 agonist; α2-antagonist. EC50: 0.18 μM.Formule :C16H19ClN4O2Couleur et forme :SolidMasse moléculaire :334.8ML324
CAS :ML324(IC50=920 nM) is a specific inhibitor of jumonji histone demethylase (JMJD2).Formule :C21H23N3O2Degré de pureté :98.22% - 98.57%Couleur et forme :SolidMasse moléculaire :349.43Ref: TM-T6593
2mg34,00€5mg49,00€10mg74,00€1mL*10mM (DMSO)79,00€25mg122,00€50mg205,00€100mg334,00€200mg494,00€PFI-2 hydrochloride
CAS :PFI-2 hydrochloride ((R)-PFI-2 hydrochloride) is a potent, highly selective, and cell-active inhibitor of the methyltransferase activity of SETD7 (IC50: 2 nM),Formule :C23H26ClF4N3O3SDegré de pureté :99.31% - 99.91%Couleur et forme :SolidMasse moléculaire :535.98Ref: TM-T4583
1mg38,00€2mg49,00€5mg80,00€10mg111,00€1mL*10mM (DMSO)122,00€25mg200,00€50mg358,00€100mg523,00€500mg1.108,00€Fucosterol
CAS :Fucosterol, from E. stolonifera, has anti-diabetic, anti-adipogenic, anti-cancer properties; it affects PPARα and C/EBPα to control fat cell formation.Formule :C29H48ODegré de pureté :98% - 99.68%Couleur et forme :White PowderMasse moléculaire :412.69BEBT-908
CAS :BEBT-908 (PI3Kα inhibitor 1) is a selective PI3Kα inhibitor (IC50 <0.1 μM). BEBT-908 also inhibits HDAC (0.1 μM≤IC50≤1 μM).Formule :C23H25N9O3SDegré de pureté :99.67%Couleur et forme :SolidMasse moléculaire :507.57Ref: TM-T16529
1mg94,00€5mg222,00€1mL*10mM (DMSO)249,00€10mg334,00€25mg562,00€50mg802,00€100mg1.063,00€200mg1.459,00€4-amino-1,8-Naphthalimide
CAS :4-amino-1,8-Naphthalimide (4-ANI) is a PARP inhibitor with IC50 of 180 nMFormule :C12H8N2O2Degré de pureté :95.13%Couleur et forme :Yellow Solid PowderMasse moléculaire :212.23-methyl-1,2-dihydroquinolin-2-one
CAS :3-methyl-1,2-dihydroquinolin-2-one is the first known micromolar inhibitors of the ATAD2 bromodomain.Formule :C10H9NODegré de pureté :99.62%Couleur et forme :SolidMasse moléculaire :159.18Ref: TM-T50035
1mg35,00€1mL*10mM (DMSO)62,00€5mg77,00€10mg103,00€25mg170,00€50mg250,00€100mg354,00€200mg480,00€dencichine
CAS :Dencichine (ODAP) is a neurotoxic agent and a haemostatic agent, which relates to modulation of the coagulation system, and fibrinolytic system.Formule :C5H8N2O5Degré de pureté :99.93% - ≥95%Couleur et forme :SolidMasse moléculaire :176.13Niraparib tosylate monohyrate
CAS :Niraparib (MK-4827), a PARP inhibitor, boosts DNA breaks to trigger genomic instability and apoptosis, offering anti-cancer effects.Formule :C26H30N4O5SDegré de pureté :97.7% - 99.99%Couleur et forme :SolidMasse moléculaire :510.61Ref: TM-T9497
5mg57,00€1mL*10mM (DMSO)66,00€10mg82,00€25mg111,00€50mg137,00€100mg205,00€200mg309,00€500mg515,00€BMS-P5 free base
CAS :BMS-P5 free base is a specific and orally active peptidylarginine deiminase 4 (PAD4) inhibitor.Formule :C27H32N6O2Degré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :472.58Ruxolitinib phosphate
CAS :Ruxolitinib phosphate (INCB18424 phosphate) is a JAK1/2 inhibitor with IC50 of 3.3 nM/2.8 nM. Cost-effective and quality-assured.Formule :C17H21N6O4PDegré de pureté :98% - >99.99%Couleur et forme :SolidMasse moléculaire :404.36Ref: TM-T3043
5mg49,00€1mL*10mM (DMSO)56,00€10mg62,00€25mg78,00€50mg92,00€100mg138,00€200mg215,00€500mg395,00€1g583,00€COH-SR4
CAS :COH-SR4 (COH-SR4 (Mitochondria uncoupler SR4)) is a uncoupler of mitochondrial oxidative phosphorylation.Formule :C13H8Cl4N2ODegré de pureté :98.96%Couleur et forme :SolidMasse moléculaire :350.03ABBV-744
CAS :ABBV-744 is a BDII-selective BET bromodomain inhibitor that inhibits BRD2/3/4. It is used in the research on inflammatory diseases, cancer, and AIDS.Formule :C28H30FN3O4Degré de pureté :97.03% - >99.99%Couleur et forme :SolidMasse moléculaire :491.55Ref: TM-T4697
1mg44,00€2mg56,00€5mg90,00€1mL*10mM (DMSO)90,00€10mg142,00€25mg284,00€50mg409,00€100mg500,00€200mg718,00€BAY 87-2243
CAS :BAY 87-2243 is a potent and selective inhibitor of hypoxia-inducible factor-1 (HIF-1).Formule :C26H26F3N7O2Degré de pureté :98% - 99.95%Couleur et forme :SolidMasse moléculaire :525.53Ref: TM-T2488
1mg34,00€2mg40,00€5mg59,00€1mL*10mM (DMSO)70,00€10mg96,00€25mg200,00€50mg334,00€100mg557,00€IOX2
CAS :IOX2 is a selective HIF PHD inhibitor, active in cells with 21 nM IC50 for PHD2/ELGN-1, not inhibiting FIH at 20uM.Formule :C19H16N2O5Degré de pureté :98% - 99.59%Couleur et forme :SolidMasse moléculaire :352.34Eicosapentaenoic Acid sodium
CAS :EPA sodium, an oral omega-3, demethylates DNA, reactivates tumor suppressors, and induces vasodilation.Formule :C20H29NaO2Couleur et forme :SolidMasse moléculaire :324.434-Phenylbutyric acid
CAS :4-Phenylbutyric acid (Benzenebutyric acid) is a HDAC inhibitor and an endoplasmic reticulum stress (ERS) inhibitor. Cost-effective and quality-assured.Formule :C10H12O2Degré de pureté :98.40% - 99.76%Couleur et forme :SolidMasse moléculaire :164.2
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