Topoisomérase
Les topoisomérases sont des enzymes qui régulent la topologie de l'ADN lors de processus tels que la réplication, la transcription et la ségrégation des chromosomes en introduisant des cassures transitoires dans les brins d'ADN pour soulager le stress torsionnel. Les inhibiteurs de topoisomérase interfèrent avec ce processus, entraînant l'accumulation de cassures dans l'ADN et l'induction de la mort cellulaire, en particulier dans les cellules à division rapide. Ces inhibiteurs sont largement utilisés comme agents chimiothérapeutiques dans le traitement du cancer. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de topoisomérase de haute qualité pour soutenir vos recherches sur la réplication de l'ADN, la thérapie contre le cancer et la régulation du cycle cellulaire.
140 produits trouvés pour "Topoisomérase"
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Ciprofloxacin monohydrochloride
CAS :Ciprofloxacin monohydrochloride (Bay-09867 hydrochloride) is a broad-spectrum antimicrobial carboxyfluoroquinoline.Formule :C17H18FN3O3·HClDegré de pureté :99.5% - 99.73%Couleur et forme :White Or Light Yellow Crystalline PowderMasse moléculaire :367.80Lomefloxacin
CAS :Lomefloxacin (SC47111A) is a synthetic broad-spectrum fluoroquinolone with antibacterial activity.Formule :C17H19F2N3O3Degré de pureté :98.59%Couleur et forme :Off-White To Yellow CrystalsMasse moléculaire :351.35Epirubicin hydrochloride
CAS :<p>Epirubicin hydrochloride (Pharmorubicin) is a Topo and Foxp3 inhibitor. Epirubicin hydrochloride has antitumor activity. Cost-effective and quality-assured.</p>Formule :C27H30ClNO11Degré de pureté :98.13% - 99.79%Couleur et forme :Orange-Red At Neutral Phs And Violet Blue Over Ph 9 (Ntp 1992)Masse moléculaire :579.98Flumequine
CAS :Flumequine (R-802) is a broad-spectrum antibiotic targeting DNA gyrase and topoisomerase IV in Gram-positive and Gram-negative bacteria.Formule :C14H12FNO3Degré de pureté :98.92% - 99.4%Couleur et forme :White Crystalline Powder SolidMasse moléculaire :261.25Berberine chloride
CAS :Berberine chloride (Natural Yellow 18) is an alkaloid from Hydrastis canadensis L., Berberidaceae, and used orally for various fungal and parasitic infections.Formule :C20H18ClNO4Degré de pureté :99.47% - 99.93%Couleur et forme :Yellow Crystalline PowderMasse moléculaire :371.80Gatifloxacin
CAS :Gatifloxacin (CG5501), a fourth-gen fluoroquinolone antibiotic, blocks bacterial DNA gyrase and topoisomerase IV.Formule :C19H22FN3O4Degré de pureté :99.50% - 99.85%Couleur et forme :White PowderMasse moléculaire :375.39Nalidixic acid sodium salt
CAS :<p>Nalidixic acid sodium salt (Baktogram) is an antimicrobial agent with a limited bacteriocidal spectrum.</p>Formule :C12H11N2NaO3Degré de pureté :99.72% - 99.95%Couleur et forme :White To Off-White PowderMasse moléculaire :254.22Mitoxantrone dihydrochloride
CAS :<p>Mitoxantrone dihydrochloride (NSC-301739) is an anthracenedione antibiotic with antineoplastic activity. Mitoxantrone is a type II topoisomerase inhibitor.</p>Formule :C22H30Cl2N4O6Degré de pureté :97.05% - >99.99%Couleur et forme :Blue-Black Solid From Water Ethanol SolidMasse moléculaire :517.4Moxifloxacin hydrochloride
CAS :Moxifloxacin hydrochloride (BAY12-8039 HCl) is a fourth generation fluoroquinolone with expanded activity against gram-positive bacteria and atypical pathogens.Formule :C21H25ClFN3O4Degré de pureté :99.91% - >99.99%Couleur et forme :SolidMasse moléculaire :437.89Levofloxacin hydrate
CAS :Levofloxacin hydrate (Cravit hydrate) is a third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity.Formule :C18H20FN3O4H2ODegré de pureté :98.26%Couleur et forme :Pale Yellow SolidMasse moléculaire :370.38Daunorubicin hydrochloride
CAS :Daunorubicin hydrochloride (Rubidomycin hydrochloride), an anthracycline aminoglycoside antineoplastic, inhibits DNA replication and repair and RNA and proteinFormule :C27H29NO10·HClDegré de pureté :96.21% - 99.53%Couleur et forme :Cancer DrugMasse moléculaire :563.99Teniposide
CAS :Teniposide (VM26), a semisynthetic derivative of podophyllotoxin with antitumor activity, inhibits DNA synthesis by forming a complex with topoisomerase II andFormule :C32H32O13SDegré de pureté :97.7% - 99.45%Couleur et forme :White Or Off-White Crystalline PowderMasse moléculaire :656.65Pefloxacin Mesylate
CAS :Pefloxacin Mesylate (Pefloxacinium mesylate) is a synthetic broad-spectrum fluoroquinolone antibacterial agent active against most gram-negative and gram-Formule :C18H24FN3O6SDegré de pureté :99.86%Couleur et forme :SolidMasse moléculaire :429.46Lurtotecan
CAS :<p>Lurtotecan (GI147211) is a semisynthetic Camptothecin analog. Lurtotecan is a topoisomerase I inhibitor with anticancer effects.</p>Formule :C28H30N4O6Degré de pureté :99.18%Couleur et forme :SoildMasse moléculaire :518.56Topotecan hydrochloride
CAS :<p>Topotecan hydrochloride (NSC609699) is an antineoplastic agent used to treat ovarian cancer.</p>Formule :C23H24ClN3O5Degré de pureté :97.88% - 99.41%Couleur et forme :White Crystalline SolidMasse moléculaire :457.92Enoxacin hydrate
CAS :<p>Enoxacin hydrate (AT-2266 hydrate) is a broad-spectrum 6-fluoronaphthyridinone antibacterial agent.</p>Formule :C15H17FN4O3H2ODegré de pureté :99.50%Couleur et forme :SolidMasse moléculaire :347.34Ciprofloxacin
CAS :<p>Ciprofloxacin (Bay-09867) mainly targets bacterial DNA Gyrase (IC50=0.22-0.31 µM) and topoisomerase IV (IC50=0.3-1.9 µM). antibiotic. High-Quality, Low-Cost!</p>Formule :C17H18FN3O3Degré de pureté :98.77% - 99.91%Couleur et forme :White PowderMasse moléculaire :331.34Doxorubicin hydrochloride
CAS :Doxorubicin hydrochloride (Adriamycin) belongs to the anthracycline class of antibiotics and is an inhibitor of human DNA topoisomerase I/II (IC50=0.8/2.67 μM).Formule :C27H29NO11·HClDegré de pureté :98% - 99.52%Couleur et forme :Orange-Red At Neutral Phs And Violet Blue Over Ph 9 (Ntp 1992)Masse moléculaire :579.99Irinotecan Hydrochloride
CAS :Irinotecan HCl, a camptothecin derivative prodrug, becomes active metabolite SN-38, inhibiting topoisomerase I to trigger apoptosis.Formule :C33H39ClN4O6Degré de pureté :98% - 99.94%Couleur et forme :Yellow Crystalline PowderMasse moléculaire :623.14Irinotecan hydrochloride trihydrate
CAS :Irinotecan hydrochloride trihydrate (CPT-11 HCl Trihydrate) keeps DNA from unwinding by inhibiting topoisomerase 1.Formule :C33H45ClN4O9Degré de pureté :98.22% - >99.99%Couleur et forme :Pale Yellow To Yellow Crystalline PowderMasse moléculaire :677.18Hycanthone
CAS :<p>Hycanthone (Etrenol(mesylate)) is a potent drug of antischistosomal.</p>Formule :C20H24N2O2SDegré de pureté :98.78%Couleur et forme :Yellow-Orange Powder (Ntp 1992)Masse moléculaire :356.48XR-11576 HCl
<p>XR-11576 HCl is a novel orally active dual topoisomerase I and II inhibitor with antitumor activity.</p>Formule :C23H25ClN4O2Degré de pureté :98.52%Couleur et forme :SoildMasse moléculaire :424.92Oxaquin TEA
<p>Oxaquin TEA (MCB-3837 TEA), a precursor compound to MCB3681, is a DNA topoisomerase inhibitor that can be used to study Clostridium difficile infections and</p>Formule :C37H48F2N5O11PDegré de pureté :99.79%Couleur et forme :SolidMasse moléculaire :807.77Etoposide
CAS :<p>Etoposide (VP-16-213) is a topoisomerase II inhibitor that inhibits DNA synthesis by forming a complex with topoisomerase II and DNA (IC50=60.3 μM).</p>Formule :C29H32O13Degré de pureté :99.19% - 99.94%Couleur et forme :Crystals From Methanol SolidMasse moléculaire :588.56Nalidixic acid
CAS :Nalidixic acid (NSC-82174), a synthetic antimicrobial, targets bacterial DNA gyrase A, with a narrow bactericidal range.Formule :C12H12N2O3Degré de pureté :99.9% - 99.95%Couleur et forme :Pale Buff Crystalline Powder Physical Description Cream-Colored Powder (Ntp 1992)Masse moléculaire :232.24Enoxacin
CAS :Enoxacin (NSC-629661) is a broad-spectrum 6-fluoronaphthyridinone antibacterial agent (fluoroquinolones) structurally related to nalidixic acid.Formule :C15H17FN4O3Degré de pureté :98.68% - 99.89%Couleur et forme :Off-White To Yellow CrystalsMasse moléculaire :320.32DRF-1042 HCl
DRF-1042 HCl is an orally active camptothecin analog with antitumor activity, inhibits DNA topoisomerase I, and is used in the study of refractory solid tumors.Formule :C22H21ClN2O6Degré de pureté :97.93%Couleur et forme :SolidMasse moléculaire :444.87Top1/2-IN-1
Compound 23, known as Top1/2-IN-1, is a dual inhibitor of Top1/2 that can be administered orally and exhibits antiproliferative effects. It induces apoptosis and cell cycle arrest in cancer cells by damaging DNA and elevating reactive oxygen species levels. Additionally, Top1/2-IN-1 demonstrates antitumor activity in vivo within xenograft models.Formule :C21H21N3O2Couleur et forme :SolidMasse moléculaire :347.41DNA Damage & Repair Compound Library
<p>A unique collection of xnum DNA Damage &amp; Repair related compounds for high throughput screening (HTS) and high content screening (HCS);</p>Couleur et forme :Odour SolidGarenoxacin
CAS :<p>Garenoxacin (BMS284756) is a novel oral des-fluoro(6) quinolone for the treatment of Gram-positive and Gram-negative bacterial infections.</p>Formule :C23H20F2N2O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :426.41Antitumor agent-102
Antitumor Agent-102 (Compound 10), a conjugate integrating a Topoisomerase I inhibitor SN38 with a glucose transporter inhibitor, specifically targetsFormule :C70H82N8O18SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1355.51NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT hydrochloride
Compound I, NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT hydrochloride, is a topoisomerase I inhibitor that demonstrates effective antibody-drug conjugate (ADC)Formule :C26H24ClN3O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :509.94Nifurpirinol
CAS :Nifurpirinol (P-7138) is an antimicrobial compound that is acutely toxic to milkfish species.Formule :C12H10N2O4Degré de pureté :99.7%Couleur et forme :SolidMasse moléculaire :246.22AuM1Gly
AuM1Gly, a topoisomerase I inhibitor, demonstrates efficacy in inhibiting the proliferation of MDA-MB-231 breast cancer cells, exhibiting IC50 values in the lowDegré de pureté :98%Couleur et forme :Odour SolidTopoisomerase I inhibitor 10
Compound 13, a topoisomerase I inhibitor 10, selectively inhibits leishmanial topoisomerase IB and exhibits antileishmanial activity.Degré de pureté :98%Couleur et forme :Odour SolidTAK1 inhibitor
CAS :<p>TAK1 inhibitor is an inhibitor, which can inhibit MCF-7, A549, DU-145 and MDA MB-231, with IC50 of 0.021, 0.14, 0.064 and 0.19, respectively.</p>Formule :C22H19ClN6O2SDegré de pureté :98%Couleur et forme :SoildMasse moléculaire :466.94Banoxantrone-d12 dihydrochloride
CAS :<p>Banoxantrone D12, a deuterium-labeled version, transforms into DNA-binding topoisomerase II inhibitor AQ4 upon reduction.</p>Formule :C22H30Cl2N4O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :529.48Voreloxin
CAS :Voreloxin (SNS-595) is a potent Topoisomerase II inhibitor with broad-spectrum anti-tumor activity. Phase 2.Formule :C18H19N5O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :401.44Topoisomerases/ribosomes-IN-1
<p>Topoisomerases/ribosomes-IN-1 (compound 30f) serves as an inhibitor targeting both ribosomes and topoisomerases, specifically exhibiting inhibitory actions against constitutively macrolide-resistant bacteria. This compound effectively suppresses bacterial protein synthesis (IC 50 : 0.647 μM) and hampers DNA replication (IC 50 : 0.218 μM).</p>Formule :C53H83FN6O15Couleur et forme :SolidMasse moléculaire :1063.26Topoisomerase II inhibitor 13
CAS :WAY-323966 suppresses Topo II, strongly halts HL-60/MX2 cancer cell growth, resists Topo II toxicity.Formule :C22H23N9Degré de pureté :99.84%Couleur et forme :SoildMasse moléculaire :413.48Dichlorogelignate
CAS :<p>Dichlorogelignate (compound 4) acts as a selective inhibitor of topoisomerase II (Topo II), achieving 100% inhibition at 50 μM [1].</p>Formule :C32H34O18Couleur et forme :SolidMasse moléculaire :706.6AuM1Phe
AuM1Phe, an N-heterocyclic carbene (NHC) metal complex, inhibits both human topoisomerase I activity and actin polymerization.Degré de pureté :98%Couleur et forme :Odour SolidTopo I/II-IN-1
<p>Topo I/II-IN-1 (compound 7t) is an effective dual inhibitor of Topo I and Topo II. It exhibits significant cytotoxicity against the MCF-7 breast cancer cell line, with an IC50 value of 7.45 μM.</p>Formule :C15H13N3S2Couleur et forme :SolidMasse moléculaire :299.414Banoxantrone (D12)
CAS :Banoxantrone D12, deuterium-labeled version, reduces to AQ4 - a stable DNA-targeting topoisomerase II inhibitor.Formule :C22H28N4O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :456.55CH-0793076
CAS :<p>CH-0793076: hexacyclic camptothecin, TP300 metabolite, targets BCRP, inhibits DNA topo I (IC50: 2.3 μM).</p>Formule :C26H26N4O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :458.51Gimatecan HCl
Gimatecan HCl (ST1481 HCL) is a potent topoisomerase I inhibitor. Gimatecan is an orally bioavailable camptothecin analogue with antitumor activity.Formule :C25H26ClN3O5Degré de pureté :97.04%Couleur et forme :SoildMasse moléculaire :483.94Chimmitecan
CAS :<p>Chimmitecan ((S)-9-Allyl-10-hydroxycamptothecin) is a potent inhibitor of topoisomerase I and displays outstanding activity in vitro and in vivo.</p>Formule :C23H20N2O5Degré de pureté :98.35%Couleur et forme :SoildMasse moléculaire :404.42Topoisomerase IIα-IN-9
CAS :Compound EN300-20599, with CAS No. 16346-97-7, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound EN300-20599 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.Formule :C14H14O4SCouleur et forme :SolidMasse moléculaire :278.32AuL1
<p>AuL1 is a topoisomerase IIα (Top II) inhibitor with DNA intercalating properties. It exhibits cytotoxic effects on tumor cells, making it a potential subject for anticancer agent research.</p>Formule :C29H50AuCl2N5Couleur et forme :SolidMasse moléculaire :736.61DTS-108
CAS :DTS-108 is a prodrug of SN38 (a topoisomerase I inhibitor). It is a conjugate formed by linking SN38 to a human oligopeptide through an esterase-sensitive crosslinker. DTS-108 exhibits anticancer activity against colorectal cancer, lung cancer, and breast cancer.Formule :C145H233N43O33S2Couleur et forme :SolidMasse moléculaire :3170.8Daun02
CAS :Daun02 is the topoisomerase inhibitor Daunorubicin prodrug.Formule :C41H44N2O20Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :884.79(4-NH2)-Exatecan
CAS :(4-NH2)-Exatecan is a topoisomerase inhibitor with potential anticancer activity for the synthesis of antibody drug conjugates (ADCs).Formule :C23H21N3O4Degré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :403.43Garenoxacin mesylate hydrate
CAS :Garenoxacin mesylate hydrate (Garenoxacin mesylate [USAN]) with potent antimicrobial activity, against common respiratory pathogens, including resistant strainsFormule :C23H20F2N2O4·CH4O3S·H2ODegré de pureté :99.56%Couleur et forme :SolidMasse moléculaire :540.53Indotecan
CAS :Indotecan (LMP-400) is an effective inhibitor of topoisomerase 1(Top1) (IC50: 300, 1200, 560 nM for P388, HCT116, MCF-7 cell lines, respectively).Formule :C26H26N2O7Degré de pureté :97% - 98%Couleur et forme :SolidMasse moléculaire :478.49Rubitecan
CAS :Rubitecan: a semisynthetic DNA topoisomerase I inhibitor with antitumor and antiviral effects.Formule :C20H15N3O6Degré de pureté :97.54%Couleur et forme :Yellow Amorphous PowderMasse moléculaire :393.35Berberine
CAS :1.Formule :C20H18NO4Degré de pureté :95.71% - 99.67%Couleur et forme :SolidMasse moléculaire :336.36Levofloxacin hydrochloride
CAS :<p>Levofloxacin is a broad-spectrum, third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity.</p>Formule :C18H21ClFN3O4Degré de pureté :99.78% - 99.98%Couleur et forme :SolidMasse moléculaire :397.8Coralyne chloride
CAS :Coralyne chloride is a protoberberine with strong anticancer activity.Formule :C22H22ClNO4Degré de pureté :98.88%Couleur et forme :SolidMasse moléculaire :399.87EIDD-1931
CAS :<p>EIDD-1931 (Beta-d-N4-hydroxycytidine) is a ribonucleoside analog with antiviral activity. It inhibits replication of SARS-CoV, MERS-CoV, and SARS-CoV-2.</p>Formule :C9H13N3O6Degré de pureté :99.14% - 99.73%Couleur et forme :SolidMasse moléculaire :259.221,4-Naphthoquinone
CAS :1,4-Naphthoquinone used as inhibitor for monoamine oxidase, DNA topoisomerase, and acetyltransferase.Formule :C10H6O2Degré de pureté :99.24% - 99.56%Couleur et forme :SolidMasse moléculaire :158.15Dxd
CAS :Dxd (OQM5SD32BQ) is a potent DNA topoisomerase I inhibitor (IC50= 0.31 μM). Dxd was used as a conjugate drug for HER2-targeted ADCs. High-Quality, Low-Cost!Formule :C26H24FN3O6Degré de pureté :98.21% - ≥98%Couleur et forme :SolidMasse moléculaire :493.48Topovale
CAS :Topovale (ARC111) is a potent inhibitor of topoisomerase I.Formule :C23H23N3O5Degré de pureté :99.94%Couleur et forme :SolidMasse moléculaire :421.45Artemisitene
CAS :<p>Artemisitene, an oxidized antimalarial derivative of Artemisinin, stems from precursors like Artemisinin B and Artemisinic acid.</p>Formule :C15H20O5Degré de pureté :99.58%Couleur et forme :SolidMasse moléculaire :280.32Topotecan
CAS :Topotecan (NSC-609669) is a Topoisomerase I inhibitor,and is an antineoplastic agent used to treat ovarian cancer that works by inhibiting DNA topoisomerases.Formule :C23H23N3O5Degré de pureté :96.14% - 98.23%Couleur et forme :Light Yellow Needle Crystal Or Crystalline PowderMasse moléculaire :421.45Betulinic acid
CAS :Betulinic acid, a lupane-type triterpene from white birch bark, has antiretroviral, antimalarial, anti-inflammatory, and anticancer properties.Formule :C30H48O3Degré de pureté :98.22% - 99.7%Couleur et forme :White Crystalline PowderMasse moléculaire :456.70Marbofloxacin
CAS :Marbofloxacin (Zeniquin) is an effective, broad-spectrum antibiotic of bacterial, which inhibits DNA replication.Formule :C17H19FN4O4Degré de pureté :99.76% - 99.84%Couleur et forme :SolidMasse moléculaire :362.36Aurintricarboxylic acid
CAS :Aurintricarboxylic acid (NSC-4056) blocks nucleases and topoisomerases, stopping nucleic acid binding.Formule :C22H14O9Degré de pureté :97.1%Couleur et forme :Deep Red Coarse Crystalline PowderMasse moléculaire :422.34Genz-644282
CAS :Genz-644282, a novel non-camptothecin topoisomerase I inhibitor for cancer treatment.Formule :C22H21N3O5Degré de pureté :97.49%Couleur et forme :SolidMasse moléculaire :407.42Berberine hydrogen sulphate
CAS :Berberine hydrogen sulphate, a plant alkaloid, has broad antimicrobial effects on bacteria, fungi, and protozoa.Formule :C20H19NO8SDegré de pureté :99% - 99.82%Couleur et forme :Yellow Crystals Off-White To Yellow PowderMasse moléculaire :433.43Belotecan hydrochloride
CAS :Belotecan hydrochloride (CKD-602) is a synthetic water-soluble camptothecin derivative and topoisomerase I inhibitor with potential antitumor activityFormule :C25H28ClN3O4Degré de pureté :99.63% - ≥95%Couleur et forme :SolidMasse moléculaire :469.96Gatifloxacin hydrochloride
CAS :Gatifloxacin hydrochloride, a fourth-gen fluoroquinolone antibiotic, blocks bacterial DNA rotase and topoisomerase IV.Formule :C19H23ClFN3O4Degré de pureté :99.85% - 99.89%Couleur et forme :SolidMasse moléculaire :411.86Razoxane
CAS :Razoxane is used as an antimitotic agent with immunosuppressive properties.Formule :C11H16N4O4Degré de pureté :99.75%Couleur et forme :SolidMasse moléculaire :268.27Phenoxodiol
CAS :Phenoxodiol (Idronoxil) activates the mitochondrial caspase system, inhibits X-linked inhibitor of apoptosis(XIAP), disrupts FLICE inhibitory protein(FLIP)Formule :C15H12O3Degré de pureté :98.07% - 99.18%Couleur et forme :SolidMasse moléculaire :240.25Idarubicin hydrochloride
CAS :Idarubicin hydrochloride (Zavedos), a hydrochloride salt form of Idarubicin, is a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells ( IC50: 3.3 ng/mL).Formule :C26H27NO9·HClDegré de pureté :98.91% - 99.96%Couleur et forme :SolidMasse moléculaire :533.95Voreloxin hydrochloride
CAS :Voreloxin hydrochloride (SNS-595 hydrochloride) is a potent inhibitor of Topoisomerase II with broad-spectrum anti-tumor activity.Formule :C18H20ClN5O4SDegré de pureté :99.84%Couleur et forme :SolidMasse moléculaire :437.9SN-38
CAS :<p>SN-38 (NK012) is the active metabolite of Irinotecan, a DNA topoisomerase I (Topo I) inhibitor, which inhibits DNA and RNA synthesis (IC50=0.077/1.3 μM).</p>Formule :C22H20N2O5Degré de pureté :98% - 99.97%Couleur et forme :Light-Yellow SolidMasse moléculaire :392.4Pixantrone dimaleate
CAS :Pixantrone dimaleate (Pixantrone Maleate) (BBR 2778 dimaleate) is an experimental antineoplastic drug.Formule :C25H27N5O10Degré de pureté :98.70% - 99.11%Couleur et forme :SolidMasse moléculaire :557.21Suramin Sodium Salt
CAS :Suramin Sodium Salt (BAY-205) is a polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding of various growth factors.Formule :C51H34N6Na6O23S6Degré de pureté :97.47% - 99.97%Couleur et forme :WhiteMasse moléculaire :1429.15(S)-10-Hydroxycamptothecin
CAS :(S)-10-Hydroxycamptothecin (10-HCPT) is a DNA topoisomerase I inhibitor, utilized as a clinical therapy agent against hepatoma.Formule :C20H16N2O5Degré de pureté :99.09% - 99.81%Couleur et forme :SolidMasse moléculaire :364.35Bisantrene
CAS :Bisantrene, an anthracene derivative, targets DNA causing breaks and replication inhibition; it's like doxorubicin minus the cardiotoxicity.Formule :C22H22N8Degré de pureté :96.07% - 98.57%Couleur et forme :SolidMasse moléculaire :398.469-amino-CPT
CAS :9-amino-CPT (Aminocamptothecin) is an inhibitor of topoisomerase I with potent anticancer activity.Formule :C20H17N3O4Degré de pureté :99.13% - 99.82%Couleur et forme :Orange-Yellow PowderMasse moléculaire :363.379-Hydroxycamptothecin
CAS :9-Hydroxycampothecin is a camptothecin derivative with anticancer activity.Formule :C20H16N2O5Degré de pureté :98.28%Couleur et forme :SolidMasse moléculaire :364.35Isosteviol
CAS :Isosteviol is a natural sweetener with anti-inflammatory, anti-tumor, glucose-lowering, and other health benefits.Formule :C20H30O3Degré de pureté :99.72% - 99.97%Couleur et forme :SolidMasse moléculaire :318.45SW044248
CAS :SW044248 is a noncanonical Top1 inhibitor. It has selective toxicity for NSCLC cells.Formule :C22H23N5O2SDegré de pureté :99.56% - 99.87%Couleur et forme :SolidMasse moléculaire :421.52Niranthin
CAS :Niranthin is a potent anti-leishmanial agent, inhibits the relaxation activity of heterodimeric type IB topoisomerase of L.Formule :C24H32O7Degré de pureté :99.8%Couleur et forme :SolidMasse moléculaire :432.51Pirarubicin
CAS :<p>Pirarubicin (Theprubicin), an anthracycline antibiotic, inhibits DNA/RNA synthesis and is used as an antineoplastic.</p>Formule :C32H37NO12Degré de pureté :97.80% - 99.15%Couleur et forme :Red Crystalline PowderMasse moléculaire :627.64Exatecan Mesylate
CAS :<p>Exatecan Mesylate (DX8951f) is a DNA topoisomerase I inhibitor (IC50: 2.2 μM, 0.975 μg/mL).</p>Formule :C25H26FN3O7SDegré de pureté :97.32% - 99.9%Couleur et forme :SolidMasse moléculaire :531.55Nitidine chloride
CAS :1.Formule :C21H18ClNO4Degré de pureté :96.59% - 99.55%Couleur et forme :SolidMasse moléculaire :383.82Prulifloxacin
CAS :<p>Prulifloxacin (NM441) is a broad-spectrum fluoroquinolone that inhibits bacterial DNA synthesis by blocking topoisomerase II and IV.</p>Formule :C21H20FN3O6SDegré de pureté :99.47%Couleur et forme :Yellow Or Slightly Yellow PowerMasse moléculaire :461.46Rabdosiin
CAS :Rabdosiin ((+)-Rabdosiin) is a natural product, and has anti-allergic activity, anti-HIV activity and inhibition on DNA topoisomerase.Formule :C36H30O16Degré de pureté :98.64% - 99.49%Couleur et forme :SolidMasse moléculaire :718.619-Methoxycamptothecin
CAS :9-Methoxycamptothecin (MCPT) has antitumour activities through topoisomerase inhibition.Formule :C21H18N2O5Degré de pureté :98.49% - 99.56%Couleur et forme :SolidMasse moléculaire :378.38Mitoxantrone
CAS :<p>Mitoxantrone: anthracenedione antibiotic, disrupts DNA/RNA replication, binds to topoisomerase II, less cardiotoxic than doxorubicin.</p>Formule :C22H28N4O6Degré de pureté :96.29% - 98.74%Couleur et forme :Blue PowderMasse moléculaire :444.48β-Lapachone
CAS :β-Lapachone (ARQ-501) is a specific DNA topoisomerase I inhibitor, and no inhibitory activities against DNA topoisomerase II or ligase.Formule :C15H14O3Degré de pureté :99.76% - 99.88%Couleur et forme :SolidMasse moléculaire :242.27Ellipticine hydrochloride
CAS :<p>Ellipticine hydrochloride (NSC-71795 (hydrochloride)) is a potent antineoplastic agent; inhibits DNA topoisomerase II activities.</p>Formule :C17H15ClN2Degré de pureté :97.18%Couleur et forme :SolidMasse moléculaire :282.76Amonafide
CAS :Amonafide (NSC-308847, AS1413) causes DNA breaks via topoisomerase II, not topoisomerase I.Formule :C16H17N3O2Degré de pureté :99.39%Couleur et forme :SolidMasse moléculaire :283.33Groenlandicine
CAS :Groenlandicine, a protoberberine alkaloid, inhibits HRAR (IC50: 154.2 μM), targets topoisomerase I, and shows potential as an anti-Alzheimer's agent.Formule :C19H16NO4Degré de pureté :98.59% - 99.77%Couleur et forme :SolidMasse moléculaire :322.34Irinotecan
CAS :Irinotecan (CPT-11), a camptothecin derivative, inhibits topoisomerase I, used for colorectal cancer treatment.Formule :C33H38N4O6Degré de pureté :98% - 99.92%Couleur et forme :SolidMasse moléculaire :586.68Bimolane
CAS :Bimolane is a topoisomerase II inhibitor.Formule :C20H32N6O6Degré de pureté :99.13% - 99.29%Couleur et forme :SolidMasse moléculaire :452.5TAS-103 dihydrochloride
CAS :<p>TAS-103 dihydrochloride (BMS-247615 dihydrochloride) is a novel anticancer agent targeting both topoisomerase (Topo) I and Topo II.</p>Formule :C20H21Cl2N3O2Degré de pureté :97.78%Couleur et forme :SolidMasse moléculaire :406.31Levofloxacin
CAS :Levofloxacin ((-)-Ofloxacin) is a synthetic fluoroquinolone antibiotic that prevents DNA replication. Cost-effective and quality-assured.Formule :C18H20FN3O4Degré de pureté :98.14% - 99.80%Couleur et forme :Off-White To Yellow CrystalsMasse moléculaire :361.37Amsacrine hydrochloride
CAS :Amsacrine hydrochloride (acridinyl anisidide hydrochloride) is topoisomerase II inhibitor , is used in the treatment of acute myelogenous leukemia.Formule :C21H20ClN3O3SDegré de pureté :99.05% - 99.92%Couleur et forme :SolidMasse moléculaire :429.92IndiMitecan
CAS :<p>IndiMitecan (LMP776) is an inhibitor of topoisomerase I (Top1) with anticancer activities [1].</p>Formule :C25H21N3O6Degré de pureté :98.53%Couleur et forme :SoildMasse moléculaire :459.45(±)-10-Hydroxycamptothecin
CAS :<p>(±)-10-Hydroxycamptothecin (Hydroxy Camptothecine) is an alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata.</p>Formule :C20H16N2O5Degré de pureté :98% - 99.06%Couleur et forme :SolidMasse moléculaire :364.35Exatecan
CAS :Exatecan (DX-8951f) is a DNA topoisomerase I (TOP1) inhibitor with an IC50 value of 2.2 μM (0.975 μg/mL).Exatecan has antitumor activity and may be used inFormule :C24H22FN3O4Degré de pureté :99.69% - 99.91%Couleur et forme :SolidMasse moléculaire :435.45Doxorubicin
CAS :Doxorubicin (Adriamycin) is a Topoisomerase II (Top2) inhibitor with antineoplastic activity.Formule :C27H29NO11Degré de pureté :99.31%Couleur et forme :Red Crystalline Solid SolidMasse moléculaire :543.52PNU-159682
CAS :PNU-159682 is a highly effective metabolite of the anthracycline nemorubicin.Formule :C32H35NO13Degré de pureté :98.24%Couleur et forme :SolidMasse moléculaire :641.62Ellipticine
CAS :Ellipticine is a powerful cancer drug with different actions, IC50: 0.27-1.48 μM for leukemia, breast cancer, neuroblastoma, glioblastoma.Formule :C17H14N2Degré de pureté :97.26% - 99.88%Couleur et forme :SolidMasse moléculaire :246.31Camptothecin
CAS :Camptothecin (CPT) belongs to the alkaloid group of natural products and is a specific DNA topoisomerase I (Topo I) inhibitor (IC50=679 nM) with specificity.Formule :C20H16N2O4Degré de pureté :99.52% - 99.88%Couleur et forme :Solid PowderMasse moléculaire :348.35Daniquidone
CAS :Daniquidone (Batracylin) is a potent dual inhibitor of DNA topoisomerase I and DNA topoisomerase II with cytotoxic and antiproliferative activity for neoplasmsFormule :C15H11N3ODegré de pureté :98.39% - 99.52%Couleur et forme :SolidMasse moléculaire :249.27BNS-22
CAS :BNS-22 is a DNA topoisomerase II (Topo II) inhibitor, induces mitotic abnormalities and exhibits antiproliferative activity against human cancer cells.Formule :C24H25NO5Degré de pureté :99.62%Couleur et forme :SolidMasse moléculaire :407.46IID432
IID432 can inhibit the topoisomerase II of Trypanosoma cruzi, with an EC50 value of 8 nM.Formule :C19H19N7OMasse moléculaire :361.4T638
CAS :T638 is an inhibitor of topoisomerase II (TOP2). It specifically inhibits the activity of TOP2A with an IC50 of 0.7 uM and effectively suppresses the growth of cancer cells.Formule :C18H16N4OSCouleur et forme :SolidMasse moléculaire :336.41Exatecan mesylate dihydrate
CAS :<p>Exatecan mesylate dihydrate (DX-8951), a DNA topoisomerase I inhibitor, exhibits an IC50 of 2.2 μM (0.975 μg/mL) and is utilized in cancer research [1] [2] [3].</p>Formule :C25H30FN3O9SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :567.58PluriSIn #2
CAS :PluriSIn #2 is a selective topoisomerase II α (topo2α) transcription inhibitor exhibiting cytotoxicity towards undifferentiated, leukaemogenic hPSCs.Formule :C11H8FN3O3Degré de pureté :98% - 99.79%Couleur et forme :SolidMasse moléculaire :249.2Amsacrine
CAS :Amsacrine (AMSA) (mAMSA) an antineoplastic agent which can intercalate into the DNA of tumor cells.Formule :C21H19N3O3SDegré de pureté :99.2% - 99.34%Couleur et forme :Yellow Crystalline Powder SolidMasse moléculaire :393.46Aldoxorubicin
CAS :Aldoxorubicin, an albumin-binding prodrug of Doxorubicin, exhibits potent antitumor effects in cancer lines and mouse models.Formule :C37H42N4O13Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :750.75Pyrazoloacridine
CAS :Pyrazoloacridine (PD 115934) binds DNA, inhibits topo I/II, has 1.25 μM IC50 in K562 cells, and exhibits anti-cancer effects.Formule :C19H21N5O3Degré de pureté :99.72%Couleur et forme :SolidMasse moléculaire :367.4Pegamotecan
CAS :Pegamotecan (PEG-camptothecin) is a topoisomerase I (TOP1) inhibitor with anticancer activity, and it is used in the treatment of esophageal, non-small cellFormule :C52H48N6O14Degré de pureté :96.40% - 97.83%Couleur et forme :SolidMasse moléculaire :980.984Pradofloxacin
CAS :Pradofloxacin is a fluoroquinolone antibioticthat exerts its bactericidal effect by inhibiting bacterial DNA gyrase and topoisomerase IV.Formule :C21H21FN4O3Degré de pureté :98.76%Couleur et forme :SolidMasse moléculaire :396.41Topoisomerase inhibitor 2
CAS :<p>Topoisomerase Inhibitor 2 (18C) is a broad-spectrum bacterial topoisomerase inhibitor effective against multidrug-resistant Gram-negative bacteria [1].</p>Formule :C23H23N5O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :433.469-Chloromethyl-10-hydroxy-11-F-Camptothecin
CAS :9-Chloromethyl-10-hydroxy-11-F-Camptothecin, a novel derivative of camptothecin, functions as a DNA topoisomerase I (Topo I) inhibitor with potentialFormule :C22H18ClFN2O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :428.84Topoisomerase I inhibitor 9
CAS :Topoisomerase I Inhibitor 9 (compound 3d), a specific inhibitor of leishmanial topoisomerase IB, exhibits antileishmanial activity, demonstrating an IC50 valueFormule :C23H15Br2FN2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :498.19Trovafloxacin mesylate
CAS :Trovafloxacin: broad-spectrum fluoroquinolone, blocks DNA gyrase/topoisomerase IV and PANX1 channel (IC50=4μM).Formule :C21H19F3N4O6SDegré de pureté :99.18%Couleur et forme :SolidMasse moléculaire :512.46Anticancer agent 216
CAS :Anticanceragent 216 (34A) is a camptothecin compound with IC50 values of 9.6 nM for MCF-7 cells and 11.6 nM for MDA-MB-231 cells.Formule :C23H21N3O6Couleur et forme :SolidMasse moléculaire :435.43NH2-methylpropanamide-Exatecan TFA
CAS :Exatecan TFA, a methylpropanamide-modified derivative of the common ADC cytotoxin Exatecan, serves as a DNA topoisomerase I inhibitor with an IC50 of 2.2 μM (0.Formule :C30H30F4N4O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :634.58Ac-Exatecan
CAS :<p>Ac-Exatecan is acetylation-modified Exatecan.Exatecan (DX-8951) is a DNA topoisomerase I (TOP1) inhibitor with an IC50 value of 2.2 μM and antitumor activity.</p>Formule :C26H24FN3O5Degré de pureté :97.09%Couleur et forme :SolidMasse moléculaire :477.48SDOX
CAS :SDOX, a prodrug, releases Doxorubicin selectively in high-GSH tumor cells, minimizing harm to healthy tissue.Formule :C69H97NO20S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1324.63LMP744 hydrochloride
CAS :<p>LMP744 hydrochloride (NSC-706744 hydrochloride) is a DNA intercalator and Topoisomerase I (Top1) inhibitor with antitumor activity. </p>Formule :C24H25ClN2O7Degré de pureté :99.59% - 99.85%Couleur et forme :SolidMasse moléculaire :488.92ARN-21934
CAS :ARN-21934 inhibits human topoisomerase II α/β; IC50=2μM; stronger than Etoposide (IC50=120μM) in DNA relaxation.Formule :C21H24N6Degré de pureté :99.8%Couleur et forme :SolidMasse moléculaire :360.46Topoisomerase II inhibitor 18
CAS :<p>Topoisomerase II inhibitor 18 (Compound IV), a Quinoxaline derivative, exhibits an IC 50 of 7.5 μM in inhibiting topoisomerase II. It impedes PC-3 cell proliferation, arrests the cell cycle at the S phase, and induces apoptosis. Moreover, this compound demonstrates substantial antitumor activity against cancer [1].</p>Formule :C20H21N3OSCouleur et forme :SolidMasse moléculaire :351.47Karenitecin
CAS :<p>Karenitecin (Cositecan) is an inhibitor of topoisomerase I. It has potent anti-cancer activity.</p>Formule :C25H28N2O4SiDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :448.59Intoplicine
CAS :Intoplicine is an inhibitor of DNA topoisomerase I and II.Formule :C21H24N4ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :348.44TH1338
CAS :<p>TH1338 is an orally active camptothecin derivative with significant blood-brain barrier permeability and cytotoxicity, used in cancer research.</p>Formule :C22H21N3O4Degré de pureté :98.77%Couleur et forme :SolidMasse moléculaire :391.42Topotecan acetate
CAS :Topotecan acetate is an inhibitor of topoisomerase.Formule :C25H27N3O7Couleur et forme :SolidMasse moléculaire :481.498LMP517
CAS :LMP517 (NSC 781517), an indenoisoquinoline, is a potent dual TOP1 and TOP2 inhibitor that shows better antitumor activity than its parent compound LMP744 against H82 (Small Cell Lung Cancer) xenografts, inducing TOP1 cleavage complexes (TOP1ccs) and TOP2ccs [1].Formule :C22H19FN2O5Couleur et forme :SolidMasse moléculaire :410.4Topoisomerase I/II inhibitor 7
CAS :<p>Compound 5h (Topoisomerase I/II inhibitor 7) is a Topoisomerase I/II inhibitor.</p>Formule :C18H13ClN2O3Couleur et forme :SolidMasse moléculaire :340.76Anticancer agent 215
CAS :Anticanceragent 215 (1) is a camptothecin derivative with IC50 values of 5.2 nM and 8.2 nM against MCF-7 and MDA-MB-231 cells, respectively.Formule :C23H22FN3O4Couleur et forme :SolidMasse moléculaire :423.44Gimatecan
CAS :Gimatecan (STI481) is a potent topoisomerase I inhibitor. Gimatecan is an orally bioavailable camptothecin analogue with antitumor activity.Formule :C25H25N3O5Degré de pureté :98.47%Couleur et forme :SolidMasse moléculaire :447.48Saintopin
CAS :Saintopin is an antitumor antibiotic and an inhibitor of DNA topoisomerases I and II, which induces DNA cleavage [1] [2].Formule :C18H10O7Couleur et forme :SolidMasse moléculaire :338.27Edotecarin
CAS :Edotecarin is a potent topoisomerase I inhibitor. It can decrease single-strand DNA cleavage (IC50: 50 nM).Formule :C29H28N4O11Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :608.55
