Endocrinologie/Hormones

<p>(R)-Equol ((+)-Equol) is an ERα and ERβ agonist with Kis of 27.4 and 15.4 nM, respectively.</p>

<p>ZT 52656A is a selective agonist of kappa opioid, and used for the prevention or alleviation of pain in the eye.</p>

<p>Flutamide (SCH 13521) is an antiandrogen with about the same potency as cyproterone in rodent and canine species.</p>

<p>Pomisartan 2HCl (BIBR363 2HCL) is a small molecule AT1R antagonist used to study heart failure and hypertension.</p>

<p>GSK256073 is an orally active GPR109A agonist.</p>

SK33 is a potent and tissue selective anti-androgen agent. SK33 reduces androgen receptor (AR) transcriptional activity.

<p>BI-671800 (AP-761) is a DP2/CRTH2 antagonist with IC50 values of 4.5 nM and 3.7 nM, potential for treating asthma.</p>

<p>Loteprednol etabonate (Lotemax) is an ophthalmic analog of the corticosteroid prednisolone with anti-inflammatory activity.</p>

<p>Samidorphan HCl is an orally active and highly potent modulator of the opioid system that binds to μ‐opioid, κ‐opioid, and delta-opioid receptors.</p>

<p>Mestranol (Devocin), a semisynthetic estrogen, is used as an estrogen receptor agonist and must be demethylated to be biologically active.</p>

<p>GW-870086 is an effective anti-inflammatory agent.</p>

MLN-4760 is a human ACE2 inhibitor with an IC50 of 0.44 nM, highly selective (>5000-fold) over testicular ACE and CPDA.

<p>Glucagon (1-29), bovine, human, porcine hydrochloride is a peptide hormone, produced by pancreatic α-cells. Glucagon increases HNF4α phosphorylation.</p>

<p>Hydrocortisone acetate (Cortisol 21-acetate) is the synthetic acetate salt form of hydrocortisone, a corticosteroid with anti-inflammatory and immunosuppressive</p>

<p>Halcinonide (Halciderm), a high-efficiency corticosteroid, is served as an anti-inflammatory agent used in topical preparations.</p>

<p>4,4'-Iminodiphenol (Leucoindophenol) is an inactive estrogen receptor ligand with a diphenylamine backbone.</p>

<p>Clobetasol propionate (CGP9555) exerts its effect by binding to cytoplasmic glucocorticoid receptors and subsequently activates glucocorticoid receptor-mediated</p>

<p>Triamcinolone (Aristocort) is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.</p>

<p>Hydrocortisone 17-butyrate (Cortisol 17-butyrate) is a glucocorticoid receptor agonist with antiinflammatory, antipruritic and vasoconstrictive effects.</p>

<p>This assay employs the competitive inhibition enzyme immunoassay technique. The microtiter plate provided in this kit has been pre-coated with Mouse INHbE protein. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse INHbE. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Mouse INHbE in the samples is then determined by comparing the OD of the samples to the standard curve.</p>