Endocrinologie/Hormones
Les inhibiteurs en endocrinologie/hormonaux sont des composés qui bloquent l'action des hormones ou interfèrent avec les voies de signalisation hormonales. Ces inhibiteurs sont essentiels pour étudier la régulation des systèmes endocriniens et pour développer des traitements pour les maladies liées aux hormones, telles que le diabète, les troubles de la thyroïde et les cancers hormonodépendants. En modulant l'activité hormonale, ces inhibiteurs peuvent aider à élucider les interactions complexes au sein du système endocrinien. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de haute qualité en endocrinologie/hormonaux pour soutenir vos recherches en endocrinologie, pharmacologie et sciences médicales.
Sous-catégories appartenant à la catégorie "Endocrinologie/Hormones"
- Récepteur des androgènes(229 produits)
- Annexine A(16 produits)
- Aromatase(22 produits)
- Récepteur d'œstrogène/progestatif(56 produits)
- GPR(1 produits)
- Récepteur des glucocorticoïdes(166 produits)
- LHRH(1 produits)
- Récepteur opioïde(326 produits)
- Récepteur de prostaglandine(122 produits)
- RAAS(90 produits)
- Réductase(50 produits)
- Somatostatine(57 produits)
- Récepteur des hormones thyroïdiennes (THR)(32 produits)
- Récepteur de la vasopressine(46 produits)
Affichez 6 plus de sous-catégories
3369 produits trouvés pour "Endocrinologie/Hormones"
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Mu opioid receptor antagonist 3
Potent, selective MOR antagonist (compound 26); crosses blood-brain barrier. Ki: 0.24 nM, EC50: 0.54 nM; for studying OUD.Formule :C25H28N2O4SCouleur et forme :SolidMasse moléculaire :452.57Emd 52297
CAS :Emd 52297 is an inhibitor of renin.Formule :C39H59N11O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :793.96AT1R antagonist 2
AT1R antagonist 2 is a potent AT1R selective ligand with good AT1R affinity (Ki: 26 nM).Formule :C29H37N5O4S2Couleur et forme :SolidMasse moléculaire :583.77MTI013
MTI013 is a selective inhibitor of SARS-CoV-2 nsp14 Mtase (IC50: 2.98 µM) and an antiviral agent (IC50: 10.33 µM in HCoV-229E infected Huh7 cells). Additionally, MTI013 demonstrates synergistic antiviral effects when used in conjunction with the RdRp inhibitor SHEN26.Formule :C24H26N6O4SCouleur et forme :SolidMasse moléculaire :494.57A4B17
A4B17 is an inhibitor of androgen receptor N-terminal with potential for androgen-responsive prostate cancer treatment.Formule :C14H7F4NSCouleur et forme :SolidMasse moléculaire :297.27Pentomone
CAS :Pentomone (LY-113935) is an anti-androgen compound that acts as a prostate growth inhibitor.Formule :C24H26O5Couleur et forme :SolidMasse moléculaire :394.46ER degrader 10
CAS :<p>ER degrader 10 (Compound 51) is an orally active estrogen receptor (ER) selective degrader and antagonist, with a DC50 of 0.43 nM and an IC50 of 0.56 nM. It inhibits the proliferation of ER-positive cells, with an IC50 ranging from 0 to 15 nM. ER degrader 10 exhibits weak inhibitory activity on the hERG channel, with an IC50 greater than 40 μM. It has blood-brain barrier permeability, with a brain/plasma ratio (Kp) of 3.05. In mouse models, ER degrader 10 demonstrates antitumor activity.</p>Formule :C28H29F2NO3SCouleur et forme :SolidMasse moléculaire :497.597ERα degrader 11
CAS :ERα degrader11 (compound B16) is a selective estrogen receptor degrader designed for use as a probe in examining the ER status within ER-positive breast cancer cells.Formule :C28H27F3N2O3Couleur et forme :SolidMasse moléculaire :496.52ADX61623
CAS :ADX61623 is an effective negative allosteric modulator (NAM) of the follicle-stimulating hormone receptor (FSHR). It also exhibits activity on the luteinizing hormone receptor (LH-R) but is inactive on the thyroid-stimulating hormone (TSH) receptor. ADX61623 can be utilized in research on estrogen-dependent diseases.Formule :C19H20N2O3Couleur et forme :SolidMasse moléculaire :324.37ACT 178882
CAS :ACT 178882 is a new Renin inhibitor (IC50: 1.4 nM).Formule :C33H38Cl3N3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :647.03Allyphenyline oxalate
CAS :<p>The pKi values of Allyphenyline oxalate (compound 9) for the α2-adrenergic receptor subtypes α2A, α2B, and α2C are 7.24, 6.47, and 7.07, respectively.</p>Formule :C16H20N2O5Couleur et forme :SolidMasse moléculaire :320.34BU09059
CAS :BU09059 is a potent, selective, short-acting antagonist of the κ-opioid receptor (KOR).Formule :C28H37N3O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :495.61Norbinaltorphimine dihydrochloride
CAS :Norbinaltorphimine dihydrochloride is a selective and potent κ opioid receptor antagonist that induces itch-associated responses in mice.Formule :C40H45Cl2N3O6Degré de pureté :98.17% - 99.88%Couleur et forme :SolidMasse moléculaire :734.71Ref: TM-T12241
1mg38,00€5mg85,00€10mg120,00€25mg235,00€50mg409,00€100mg652,00€200mg908,00€1mL*10mM (DMSO)124,00€Naldemedine tosylate
CAS :Naldemedine (S-297995) tosylate, a PAMORA, targets μ-, δ-, κ-opioid receptors, aiding OIC research, may bind to SARS-CoV2's 3CL pro.Formule :C39H42N4O9SCouleur et forme :SolidMasse moléculaire :742.84Glucocorticoid receptor activator 1
CAS :Glucocorticoid Receptor Activator 1, a phenyl nitrogen-heterocyclic precursor, acts as an activator of the glucocorticoid receptor (GR). By activating GR, it downregulates the expression of pro-inflammatory genes stimulated by TNF, making it useful for inflammation research.Formule :C11H15Cl2NO2Couleur et forme :SolidMasse moléculaire :264.15Androgen receptor antagonist 12
CAS :Compound EF2 (Androgen receptor antagonist 12) is an orally active antagonist of the androgen receptor (AR) with an IC50 of 0.30 µM. It inhibits the transcriptional activity of mutant AR and the proliferation of AR-positive PCa (prostate cancer) cell lines. Additionally, Compound EF2 blocks the nuclear translocation of AR and suppresses tumor growth in the C4-2B xenograft mouse model. This compound is used for research in prostate cancer.Formule :C12H8F3N3O2Couleur et forme :SolidMasse moléculaire :283.2122-Hydroxy mifepristone
CAS :22-Hydroxy Mifepristone (RU 42698) is an orally active hydroxylated alcohol metabolite that exhibits both anti-progestational and anti-glucocorticoid activities. This compound contains an alkyne group and is capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAC) with azide-containing molecules. Furthermore, 22-Hydroxy Mifepristone demonstrates a relative binding affinity of 48% to the human glucocorticoid receptor.Formule :C29H35NO3Couleur et forme :SolidMasse moléculaire :445.59LX1
CAS :LX1, an anti-prostate cancer compound, specifically targets the androgen receptor (AR), AR variants, and the steroidogenic enzyme AKR1C3. It inhibits AKR1C3's enzymatic function, decreases the conversion of androstenedione to testosterone, and reduces the expression of both AR and AR-V7, subsequently downregulating their target genes. Additionally, LX1 is effective in overcoming tumor cell resistance to Enzalutamide, and when combined with Enzalutamide, it further suppresses tumor growth.Formule :C22H15F6NO2Couleur et forme :SolidMasse moléculaire :439.35Androgen receptor degrader-5
CAS :Androgen receptor degrader-5 (compound 14k) demonstrates superior capabilities, specifically in androgen receptor degradation and antiproliferative activity, showcasing its promising properties.Formule :C29H25F4N5O2Couleur et forme :SolidMasse moléculaire :551.53FL442
CAS :FL442 is an Androgen Receptor (AR) modulator. This compound exhibits potent inhibitory effects in AR-dependent prostate cancer cells, showing similar suppression efficiency to the traditional antiandrogen drugs Bicalutamide and Enzalutamide. It also maintains antiandrogen activity against the Enzalutamide-resistant AR mutant F876L. The pharmacokinetic properties of FL442 in mice reveal a longer half-life (8 hours), excellent targeting (prostate tissue), and metabolic stability. Additionally, it is effective at inhibiting LNCaP tumor growth at low plasma concentrations (30 ng/mL).Formule :C15H13F3N2OCouleur et forme :SolidMasse moléculaire :294.27
