ERK
ERK est une protéine clé de la voie de signalisation MAPK (Mitogen-Activated Protein Kinase), qui est impliquée dans la transmission des signaux des récepteurs de surface cellulaire à l'ADN dans le noyau de la cellule. ERK joue un rôle crucial dans la régulation de divers processus cellulaires, y compris la prolifération, la différenciation et la survie. La dérégulation de la signalisation ERK est associée au développement du cancer et d'autres maladies, ce qui en fait une cible importante pour les interventions thérapeutiques. Chez CymitQuimica, nous offrons une sélection d'inhibiteurs et de modulateurs d'ERK de haute qualité pour soutenir vos recherches en signalisation cellulaire, oncologie et développement thérapeutique.
194 produits trouvés pour "ERK"
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Mefloquine hydrochloride
CAS :Mefloquine hydrochloride (Mefloquin hydrochloride) is a quinoline derivative used for the prevention and therapy of P. falciparum malaria.Formule :C17H17ClF6N2ODegré de pureté :99% - 99.99%Couleur et forme :Off-White To Yellow SolidMasse moléculaire :414.77MRTX-1257
CAS :<p>MRTX-1257: selective, irreversible KRAS G12C inhibitor; IC50 of 900 pM; 31% bioavailable in mice; 77% target engagement.</p>Formule :C33H39N7O2Degré de pureté :97.3% - 99.07%Couleur et forme :SolidMasse moléculaire :565.71LUT014
CAS :<p>LUT014 is a B-Raf inhibitor (IC50: 11.7 nM) and developed to decrease dose-limiting acneiform lesions associated with EGFR Inhibitors treatment.</p>Formule :C27H19F3N8ODegré de pureté :99.03%Couleur et forme :SolidMasse moléculaire :528.49Lidocaine
CAS :<p>Lidocaine, an amide local anesthetic, reduces pain and inflammation by dampening ICAM-1, cytokines, and neutrophil influx.</p>Formule :C14H22N2ODegré de pureté :99.95% - >99.99%Couleur et forme :Needles From Benzene Or Alcohol SolidMasse moléculaire :234.34Lidocaine hydrochloride
CAS :<p>Lidocaine HCl: local anesthetic, antiarrhythmic, stronger & longer-lasting than procaine but shorter than bupivacaine/prilocaine.</p>Formule :C14H23ClN2ODegré de pureté :99.81% - 99.92%Couleur et forme :White Crystal PowderMasse moléculaire :270.798(E/Z)-BCI
CAS :<p>(E/Z)-BCI (NSC-150117), a dual-specificity phosphatase 6 (DUSP6) inhibitor with anti-inflammatory properties, reduces LPS-induced inflammatory mediators and ROS</p>Formule :C22H23NODegré de pureté :99.94%Couleur et forme :SolidMasse moléculaire :317.42Methylthiouracil
CAS :<p>Methylthiouracil (NSC-193526) is a thiourea antithyroid agent that inhibits the synthesis of thyroid hormone, and it is used to treat hyperthyroidism.</p>Formule :C5H6N2OSDegré de pureté :99.89% - >99.99%Couleur et forme :Crystals Saturated Aqueous Solution Is Neutral Or Slightly Acidic (Ntp 1992)Masse moléculaire :142.18CC-90003
CAS :<p>CC-90003 is a selective inhibitor of ERK 1/2. It has antitumor activity.</p>Formule :C22H21F3N6O2Degré de pureté :99.42%Couleur et forme :SolidMasse moléculaire :458.44Mefloquine
CAS :<p>Mefloquine (Ro 215998), a quinoline antimalarial agent, is an anti-SARS-CoV-2 entry inhibitor.</p>Formule :C17H16F6N2ODegré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :378.31ERK5-IN-6
CAS :<p>ERK5-IN-6 is an ERK5 kinase inhibitor with antiproliferative, anticonvulsant, and antitumor activity for the study of central nervous system related diseases.</p>Formule :C23H21N3Degré de pureté :98.59%Couleur et forme :SoildMasse moléculaire :339.43MK2-IN-3 hydrate
CAS :<p>MK2-IN-3 hydrate (MK-2 Inhibitor III) is an orally active, selective, and ATP-competitive inhibitor of MAPKAP-K2 (MK-2) (IC50 of 0.85 nM)</p>Formule :C21H18N4O2Degré de pureté :99.58%Couleur et forme :SolidMasse moléculaire :358.39AX-15836
CAS :AX-15836 is an inhibitor of ERK5 (IC50 : 8 nM).Formule :C32H40N8O5SDegré de pureté :98.96%Couleur et forme :SolidMasse moléculaire :648.78Honokiol
CAS :<p>Honokiol (NSC-293100) is the active principle of magnolia extract. It inhibits the activation of Akt and enhances the phosphorylation of ERK1/ERK2.</p>Formule :C18H18O2Degré de pureté :99.65% - 99.94%Couleur et forme :Dark Brown To White Fine Powder With Pleasant Odor Spicy And Slightly Bitter TasteMasse moléculaire :266.33Lidocaine Hydrochloride hydrate
CAS :<p>Lidocaine Hydrochloride hydrate is an amide local anesthetic, has anti-inflammatory property.</p>Formule :C14H22N2O·HCl·H2ODegré de pureté :99.95%Couleur et forme :SolidMasse moléculaire :288.82Urolithin B
CAS :Urolithin B is one of the gut microbial metabolites of ellagitannins and is found in diverse plant foods, including pomegranates, berries, walnuts, tropicalFormule :C13H8O3Degré de pureté :99.45%Couleur et forme :SolidMasse moléculaire :212.2ERK5-IN-5
CAS :ERK5-IN-5 is extracellular signal-regulated kinase 5 (ERK5) inhibitor with anticancer activity anticonvulsant activity inhibits A549 cell proliferation.Formule :C19H16ClN3ODegré de pureté :99.89%Couleur et forme :SoildMasse moléculaire :337.8Emodic acid
CAS :<p>Emodic acid is a useful organic compound for research related to life sciences. The catalog number is T124807 and the CAS number is 478-45-5.</p>Formule :C15H8O7Couleur et forme :SolidMasse moléculaire :300.222KRAS G12C inhibitor 69
<p>KRAS G12C inhibitor 69 (Compound K09) is an inhibitor of the mutant RAS protein KRAS G12C with an IC50 of 4.36 nM. In the cell lines NCI-H358 and MIA-PACA-2, it suppresses ERK phosphorylation with IC50 values of 12 nM and 7 nM, respectively. Additionally, KRAS G12C inhibitor 69 hinders the proliferation of NCI-H358 and MIA-PACA-2 cancer cells, with IC50 values of 3.15 nM and 2.33 nM, respectively.</p>Formule :C29H29ClF3N5O3Couleur et forme :SolidMasse moléculaire :588.02ROCK-IN-5
CAS :<p>ROCK-IN-5 (I-B-37) inhibits kinases like ROCK/ERK/GSK; may aid in cardiac and neuro disease studies.</p>Formule :C16H11ClFN3OSDegré de pureté :99.72% - 99.83%Couleur et forme :SolidMasse moléculaire :347.79ERK1/2 inhibitor 3
CAS :<p>ERK1/2 inhibitor 3, a strong ERK1/2 blocker, may aid in cancer and inflammation research.</p>Formule :C28H31ClFN5O6SCouleur et forme :SolidMasse moléculaire :620.09TAT-DEF-Elk-1
CAS :<p>TAT-DEF-Elk-1 is a cell-penetrating peptide Elk-1 inhibitor.</p>Formule :C155H259N57O40Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3561.136BTX6654
<p>BTX-6654 is a cereblon-based bifunctional SOS1 PROTAC degrader. This compound exhibits antiproliferative activity against cells with various KRAS mutations by reducing the expression of downstream signaling markers pERK and pS6.</p>Formule :C50H57F4N9O5Couleur et forme :SolidMasse moléculaire :940.04STE-MEK1(13)
CAS :<p>STE-MEK1(13), a cell-permeable ERK1/2 inhibitor with IC50 values ranging from 13 to 30 μM, impedes the phosphorylation of ERK1/2, as demonstrated in studies [1</p>Formule :C86H153N19O17SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1757.32PROTAC MEK1 Degrader-1
CAS :<p>PROTAC MEK1 Degrader-1, a targeted protein degradation agent, combines a MEK1 inhibitor with a von Hippel-Lindau ligand to effectively inhibit ERK1/2</p>Formule :C53H66FIN8O11S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1201.17Anti-inflammatory agent 35
CAS :<p>Anti-inflammatory agent 35 is a potent anti-inflammatory agent.</p>Formule :C27H29NO8Degré de pureté :99.98%Couleur et forme :SoildMasse moléculaire :495.52Kinase Inhibitor Library
<p>A unique collection of 2720 kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;</p>Couleur et forme :Odour SolidMAPK Inhibitor Library
<p>A unique collection of 365 compounds targeting MAPK signaling for drug discovery in MAPK related diseases;</p>Couleur et forme :Odour Solid4-P-PDOT
CAS :<p>4-P-PDOT (4-phenyl-2- propionamidotetralin) is a potent, selective and affinity Melatonin receptor (MT2) antagonist.</p>Formule :C19H21NODegré de pureté :99.91%Couleur et forme :SolidMasse moléculaire :279.38VSLRGDTRG
CAS :<p>VSLRGDTRG is a synthetic peptide derived from the RGD motif in cadherin17 (CDH17) that binds to the α2β1 integrin, activating its signaling pathways. By promoting high-affinity conformational changes in β1 integrins through the RGD motif, VSLRGDTRG enhances cell adhesion and the phosphorylation of FAK and ERK1/2, thereby driving tumor proliferation and metastasis. This peptide is useful for research on cancers expressing CDH17, such as colorectal and pancreatic cancer.</p>Formule :C38H69N15O14Couleur et forme :SolidMasse moléculaire :960.047Rineterkib hydrochloride
CAS :<p>Rineterkib hydrochloride (B) is an oral RAF/ERK1/2 inhibitor for MAPK-driven cancers, including KRAS/BRAF-mutant NSCLC and CRC.</p>Formule :C26H28BrClF3N5O2Couleur et forme :SolidMasse moléculaire :614.89LC-SF-14
<p>LC-SF-14 is a selective dual inhibitor of SHP2 and FGFR, with IC50 values of 71.6 nM and 8.9 nM, respectively. It blocks FGFR2-FRS2α-SHP2-MAPK signaling and ERK phosphorylation, and also inhibits the proliferation of KATOIII cancer cells (IC50: 9.2 nM). Furthermore, LC-SF-14 exhibits antitumor activity in SNU-16 xenograft mouse models, making it suitable for research on FGFR2-driven gastric cancer.</p>Formule :C44H50Cl3N13O5SCouleur et forme :SolidMasse moléculaire :977.28442A-674563 HCl (552325-73-2(free base))
CAS :<p>A-674563: Oral Akt inhibitor (Ki: 11 nM for Akt1), also targets PKA/Cdk2, with 10-1800x selectivity over other kinases.</p>Formule :C22H23ClN4ODegré de pureté :≥98%Couleur et forme :SolidMasse moléculaire :394.9Fulipiftide
CAS :<p>Fulipiftide is a short peptide derived from pigment epithelium-derived factor (PEDF). It stimulates the amplification of nuclear stem cell factor+TSPC by activating the ERK2 and STAT3 signaling pathways. Fulipiftide also exhibits anti-inflammatory properties and is applicable in research on acute tendon injuries.</p>Formule :C144H227N41O47Couleur et forme :SolidMasse moléculaire :3284.59GSK143
CAS :<p>GSK143: Oral SYK inhibitor, pIC50=7.5, curbs pErk, anti-inflammatory, hinders immune cells in mice.</p>Formule :C17H22N6O2Couleur et forme :SolidMasse moléculaire :342.403Anti-inflammatory agent 31
Andrographolide derivative 31 is an anti-inflammatory that blocks NF-κB, PI3K/Akt, and ERK1/2 MAPK, and restores GSH levels to protect the liver.Formule :C19H30O3Couleur et forme :SolidMasse moléculaire :306.44Astragaloside
CAS :<p>Astragaloside, one of the main active ingredients in Astragalus membranaceus.</p>Formule :C28H32O17Degré de pureté :99.9%Couleur et forme :Odour SolidMasse moléculaire :640.54Olomoucine
CAS :<p>Olomoucine hinders Cdk2, Cdc2, CDK5, ERK1, regulates the cell cycle, and fights melanoma; IC50s: 3-25 µM.</p>Formule :C15H18N6ODegré de pureté :99.77%Couleur et forme :White Crystalline PowderMasse moléculaire :298.344′-Demethylnobiletin
CAS :<p>4′-Demethylnobiletin, a bioactive metabolite, activates the PKA/ERK/CREB signaling pathway, enhances CRE-mediated transcription in hippocampal neurons, and</p>Formule :C20H20O8Couleur et forme :SolidMasse moléculaire :388.37Edaxeterkib
CAS :<p>Edaxeterkib is a potent extracellular signal- regulated kinase (ERK) inhibitor for the research of cancer.</p>Formule :C26H27N7O2Couleur et forme :SolidMasse moléculaire :469.549PD 198306
CAS :<p>PD 198306: a MEK inhibitor with antihyperalgesic properties, reduces Streptozocin-boosted active ERK1.</p>Formule :C18H16F3IN2O2Degré de pureté :99.66%Couleur et forme :SolidMasse moléculaire :476.23MHJ-627
<p>MHJ-627, a potent inhibitor of ERK5 (MAPK7) with an IC50 value of 0.91 μM, enhances the mRNA expression of tumor suppressors and anti-metastatic genes, leading</p>Formule :C34H45BrN2O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :609.64Endothelin-1 (1-31) (Human) TFA
<p>Endothelin-1 (1-31) (Human) TFA, a potent vasoconstrictor and hypertensive agent, originates from the chymase-mediated selective hydrolysis of big ET-1 [1].</p>Formule :C164H237F3N38O49S5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3742.18Laxiflorin B-4
<p>Laxiflorin B-4, a derivative of Laxiflorin B, demonstrates increased affinity for ERK1/2 and enhanced tumor-suppressive effects [1].</p>Degré de pureté :98%Couleur et forme :Odour SolidMK2-IN-5
CAS :<p>MK2-IN-5, a pseudosubstrate of Mk2 with an inhibition constant (K_i) of 8 μM, selectively targets the protein interaction domain of the MAPK pathway and</p>Formule :C61H113N21O16Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1396.68VSLRGDTRG acetate
<p>VSLRGDTRG acetate is a synthetic peptide of the RGD motif from cadherin17 (CDH17), capable of binding to α2β1 integrin and activating its signaling pathways. It facilitates the high-affinity conformational change of β1 integrin via the RGD motif, enhancing cell adhesion and phosphorylation of FAK and ERK1/2, thereby promoting tumor proliferation and metastasis. VSLRGDTRG acetate is applicable in research on cancers expressing CDH17, such as colon and pancreatic cancers.</p>Couleur et forme :Odour SolidSOS1-IN-18
<p>SOS1-IN-18 (Compound 8) is an inhibitor of the Son of Sevenless 1 protein (SOS1) with a dissociation constant (KD) of 2.6 nM. It disrupts the SOS1-KRAS G12C interaction with an IC50 of 3.4 nM, inhibits ERK phosphorylation in H358 cells with an IC50 of 31 nM, and curtails the proliferation of H358 cells with an IC50 of 5 nM.</p>Formule :C26H29F3N4O2Couleur et forme :SolidMasse moléculaire :486.53PPM-3
<p>PPM-3, a selective PROTAC ERK5 degrader, exhibits a potent inhibitory concentration (IC 50) of 62.4 nM.</p>Formule :C54H69N11O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1000.26SCH772984 HCl
<p>SCH772984 HCl selectively inhibits ERK1/2, acts like type I/II kinase inhibitors, and is potent at 4/1 nM IC50s in certain mutated tumor cells.</p>Formule :C33H34ClN9O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :624.14CHPG hydrochloride
<p>CHPG hydrochloride is a selective agonist of mGluR5.</p>Formule :C8H9Cl2NO3Degré de pureté :98.1%Couleur et forme :SoildMasse moléculaire :238.07TRPM4 inhibitor 8
CAS :<p>TRPM4 inhibitor 8 is an inhibitor of Transient receptor potential melastatin 4(TRPM4) which contributes to viability, migration, cell cycle shift, and adhesion.</p>Formule :C11H17BrN2Degré de pureté :97%Couleur et forme :SolidMasse moléculaire :257.17EphB2 Protein, Human, Recombinant (His)
EphB2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.Couleur et forme :Lyophilized PowderMasse moléculaire :59.2 kDa (predicted); 65-75 kDa (reducing condition, due to glycosylation)ERK2 Protein, Mouse, Recombinant (His & GST)
<p>ERK2 Protein, Mouse, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag.</p>Couleur et forme :Lyophilized PowderMasse moléculaire :69.1 kDa (predicted); 60 kDa (reducing conditions)EphB2 Protein, Mouse, Recombinant (hFc)
EphB2 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag.Couleur et forme :Lyophilized PowderMasse moléculaire :84.6 kDa (predicted); 96.6 kDa (reducing conditions)EphB2 Protein, Human, Recombinant (aa 570-987, His & GST)
<p>EphB2 Protein, Human, Recombinant (aa 570-987, His & GST) is expressed in Baculovirus insect cells with His and GST tag.</p>Couleur et forme :Lyophilized PowderMasse moléculaire :75.2 kDa (predicted); 65 kDa (reducing conditions)EPHB2 Protein, Cynomolgus, Recombinant (His)
<p>EphB2, a receptor tyrosine kinase for ephrin ligands, is overexpressed in various cancers and plays an important role in tumor progression.</p>Couleur et forme :Lyophilized PowderMasse moléculaire :59.09 kDa (predicted). Due to glycosylation, the protein migrates to 65-75 kDa based on Tris-Bis PAGE result.EM127
CAS :<p>EM127: covalent SMYD3 inhibitor, KD 13μM, impedes ERK1/2, hinders SMYD3 gene regulation, long-term methyltransferase reduction, potential in cancer study.</p>Formule :C14H18ClN3O3Degré de pureté :97.61%Couleur et forme :SolidMasse moléculaire :311.76ERα degrader-2
CAS :ERα degrader-2 is an estrogen receptor (SERD) degrader with anticancer activity that inhibits ERα for the prevention and treatment of HER-positive breast cancFormule :C29H27F3N2O2Degré de pureté :99.71%Couleur et forme :SolidMasse moléculaire :492.53PERK-IN-2
CAS :<p>PERK-IN-2 is a potent inhibitor of PERK(IC50 of 0.2 nM).</p>Formule :C23H18F3N5ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :437.42EphB2 Protein, Mouse, Recombinant (His)
<p>EphB2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.</p>Couleur et forme :Lyophilized PowderMasse moléculaire :59.3 kDa (predicted); 65 kDa (reducing conditions)EphB2 Protein, Human, Recombinant (His & hFc)
<p>EphB2 Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag.</p>Couleur et forme :Lyophilized PowderMasse moléculaire :86 kDa (predicted); 90-100 kDa (reducing condition, due to glycosylation)Pamoic acid disodium
CAS :Pamoic acid disodium is a GPR35 agonist.Formule :C23H16NaO6Degré de pureté :99.73%Couleur et forme :Yellow PowderMasse moléculaire :411.36ERK2 Protein, Human, Recombinant (GST)
<p>ERK2 Protein, Human, Recombinant (GST) is expressed in Baculovirus insect cells with GST tag.</p>Couleur et forme :Lyophilized PowderMasse moléculaire :67 kDa (predicted); 67 kDa (reducing conditions)(E/Z)-BIX02188
CAS :<p>BIX02188 inhibits MEK5 (IC50: 4.3 nM) and ERK5 (810 nM) but not MEK1/2, JNK2, or ERK2.</p>Formule :C25H24N4O2Degré de pureté :97.39% - 98.38%Couleur et forme :SolidMasse moléculaire :412.48Avicularin
CAS :<p>Avicularin reduces inflammation via ERK pathway in RAW 264.7 cells and hinders lipid buildup in adipocytes by limiting glucose uptake and fatty acid synthesis.</p>Formule :C20H18O11Degré de pureté :97.02% - 99.94%Couleur et forme :White PowderMasse moléculaire :434.35Corynoxeine
CAS :<p>Corynoxeine inhibits ERK1/2, curbs VSMC growth induced by PDGF-BB, and may prevent vascular diseases and restenosis post-angioplasty.</p>Formule :C22H26N2O4Degré de pureté :98.61% - 99.73%Couleur et forme :SolidMasse moléculaire :382.45Aurothiomalate sodium
CAS :<p>Sodium aurothiomalate (Miochrysin) inhibits PKC-ι, TrxR; used as an anti-rheumatic and has anti-tumor properties.</p>Formule :C4H3AuNa2O4SDegré de pureté :99.66%Couleur et forme :SoildMasse moléculaire :390.07VX-11e
CAS :VX-11e (TCS ERK 11e) is a potent, selective, and orally bioavailable ERK(Extracellular Signal-Regulated Kinase) inhibitor; antitumor agent.Formule :C24H20Cl2FN5O2Degré de pureté :98.92% - ≥98%Couleur et forme :SolidMasse moléculaire :500.35HS-1793
CAS :<p>HS-1793, resveratrol-like, reduces HIF-1, VEGF in hypoxia, and curbs human breast cancer growth in mouse model.</p>Formule :C16H12O3Degré de pureté :98.16% - 99.82%Couleur et forme :SolidMasse moléculaire :252.26ERK1/2 inhibitor 2
CAS :<p>ERK1/2 inhibitor 2 (ASTX029) is a selective and orally bioavailable ERK 1/2 inhibitor, with potential antineoplastic activity.</p>Formule :C29H31ClFN5O5Degré de pureté :98.99%Couleur et forme :SolidMasse moléculaire :584.04Astragaloside IV
CAS :<p>Astragaloside IV suppresses ERK1/2, JNK, MMP-2/9 in breast cancer; inhibits adenovirus and protects cardiovascular, immune, digestive, nervous systems.</p>Formule :C41H68O14Degré de pureté :99% - 99.84%Couleur et forme :Hydroscopic Brown Or Yellow PowderMasse moléculaire :784.97magnolin
CAS :<p>Magnolin reduces the renal oxidative stress, suppresses caspase-3 activity, and increases Bcl-2 expression in vivo and in vitro.</p>Formule :C23H28O7Degré de pureté :98% - 99.77%Couleur et forme :SolidMasse moléculaire :416.46Gypenoside L
CAS :<p>Gypenoside L inhibits autophagic flux and induces cell death in human esophageal cancer cells through endoplasm reticulum stress-mediated Ca2+ release.</p>Formule :C42H72O14Degré de pureté :99.42% - 99.65%Couleur et forme :SolidMasse moléculaire :801.01Longdaysin
CAS :Longdaysin is an inhibitor of CK1α and CK1δ (IC50s: 5.6/8.8 μM). It also can inhibit ERK2 (IC50: 52 μM).Formule :C16H16F3N5Degré de pureté :99.97%Couleur et forme :SolidMasse moléculaire :335.33A-443654
CAS :<p>A-443654 is a pan-Akt inhibitor. A-443654 has equal potency against Akt1, Akt2, or Akt3 within cells (Ki=160 pM).</p>Formule :C24H23N5ODegré de pureté :98.04% - 99.51%Couleur et forme :SolidMasse moléculaire :397.47SEW2871
CAS :<p>SEW 2871 is an orally available, highly selective S1P1 agonist. It activates ERK, Akt and Rac signaling pathways and induces S1P1 internalization and recycling.</p>Formule :C20H10F6N2OSDegré de pureté :99.96%Couleur et forme :White SolidMasse moléculaire :440.36BIX02189
CAS :<p>BIX02189 is a potent and selective inhibitor of MEK5 and ERK5(IC50 : 1.5 nM and 59 nM).</p>Formule :C27H28N4O2Degré de pureté :97.84%Couleur et forme :SolidMasse moléculaire :440.54PD98059
CAS :<p>PD98059 is an MEK inhibitor that inhibits MEK1 and MEK2 (IC50=2/50 μM) and is non-ATP-competitive.</p>Formule :C16H13NO3Degré de pureté :98.63% - >99.99%Couleur et forme :Yellow SolidMasse moléculaire :267.28Piperlongumine
CAS :<p>Piperlongumine (Piplartine) is a natural alkaloid from Piper longum L.</p>Formule :C17H19NO5Degré de pureté :97.03% - 99.90%Couleur et forme :SolidMasse moléculaire :317.34TBHQ
CAS :TBHQ (tert-Butylhydroquinone) is an antioxidant that induces an antioxidant response through the redox-sensitive transcription factor Nrf2.Formule :C10H14O2Degré de pureté :99.17% - 99.53%Couleur et forme :White Solid PowderMasse moléculaire :166.22SCH772984
CAS :<p>SCH772984 is an ERK inhibitor and is highly selective and ATP-competitive. SCH772984 exhibits antitumor activity. Cost-effective and quality-assured.</p>Formule :C33H33N9O2Degré de pureté :97.565% - 98.75%Couleur et forme :SolidMasse moléculaire :587.67Theliatinib
CAS :<p>Theliatinib: potent, selective EGFR inhibitor, anti-tumor; Ki=0.05 nM (EGFR), IC50=3 nM (EGFR), 22 nM (T790M/L858R).</p>Formule :C25H26N6O2Degré de pureté :99.67%Couleur et forme :SolidMasse moléculaire :442.51Periplocin
CAS :<p>Periplocin fights lung cancer, induces apoptosis, stunts growth via beta-catenin/Tcf, and treats rheumatoid arthritis/traditional ailments.</p>Formule :C36H56O13Degré de pureté :99.66% - 99.74%Couleur et forme :SolidMasse moléculaire :696.82SC99
CAS :SC99 inhibits JAK2-STAT3, reducing STAT3 genes, platelet activity, and has anti-myeloma, anti-thrombotic effects.Formule :C15H8Cl2FN3ODegré de pureté :99.56%Couleur et forme :SolidMasse moléculaire :336.15Yoda 1
CAS :<p>Yoda 1 is an agonist of the Piezo1 channel that agonizes human- and mouse-derived Piezo1. Yoda 1 is also an inhibitor of GlyT2. Cost-effective, quality assurance.</p>Formule :C13H8Cl2N4S2Degré de pureté :98% - 99.98%Couleur et forme :SolidMasse moléculaire :355.27ERK5-IN-2
CAS :<p>ERK5-IN-2 is an orally active, sub-micromolar, selective ERK5 inhibitor with IC50s of 0.82 μM, 3 μM for ERK5 and ERK5 MEF2D, respectively.</p>Formule :C17H11BrFN3O2Degré de pureté :99.01%Couleur et forme :SolidMasse moléculaire :388.19Asperulosidic acid
CAS :<p>Asperulosidic acid (ASPA) has anti-tumor, anti-oxidant, and anti-inflammatory activities. ASPA is related to the inhibition of inflammatory cytokines.</p>Formule :C18H24O12Degré de pureté :99.47%Couleur et forme :SolidMasse moléculaire :432.38CAFESTOL
CAS :<p>Cafestol, an ERK inhibitor, suppresses PGE2 and COX-2 by blocking NF-kB in LPS-stimulated RAW264.7 cells.</p>Formule :C20H28O3Degré de pureté :97.06% - 99.08%Couleur et forme :SolidMasse moléculaire :316.43Sulforaphene
CAS :<p>Sulforaphene, from radish seeds, aids cancer cell apoptosis and inhibits migration; has an ED50 for velvetleaf at ~2x10^-4 M.</p>Formule :C6H9NOS2Degré de pureté :97.55% - 99.19%Couleur et forme :Slightly Yellowish LiquidMasse moléculaire :175.27Acalabrutinib
CAS :<p>Acalabrutinib (ACP-196), also known as ACP-196, is an orally available inhibitor of Bruton's tyrosine kinase (BTK) with potential antineoplastic activity.</p>Formule :C26H23N7O2Degré de pureté :98.94% - 99.64%Couleur et forme :SolidMasse moléculaire :465.51XMD8-92
CAS :<p>XMD8-92 is an effective and specific BMK1/ERK5 inhibitor (Kd: 80 nM).</p>Formule :C26H30N6O3Degré de pureté :98.21%Couleur et forme :SolidMasse moléculaire :474.55Triptonide
CAS :<p>Triptonide treats autoimmune diseases, has antileukemic/tumor effects, is anti-inflammatory, and boosts IL-37.</p>Formule :C20H22O6Degré de pureté :99.11% - 99.64%Couleur et forme :White Crystalline PowderMasse moléculaire :358.39Peramivir Trihydrate
CAS :<p>Peramivir Trihydrate (RWJ-270201) is a neuraminidase inhibitor (IC50: 0.09 nM) which prevents normal processing of virus particles such that virus particles are</p>Formule :C15H28N4O4·3H2ODegré de pureté :99.52% - ≥95%Couleur et forme :SolidMasse moléculaire :382.45Ulixertinib
CAS :<p>Ulixertinib (VRT752271) (BVD-523, VRT752271) is an effective and reversible ERK1/ERK2 inhibitor. The IC50 of Ulixertinib is less than 0.3 nM for ERK2.</p>Formule :C21H22Cl2N4O2Degré de pureté :99.31% - 99.95%Couleur et forme :SolidMasse moléculaire :433.33N-tert-butyl-α-Phenylnitrone
CAS :N-tert-butyl-α-Phenylnitrone ((Z)-N-benzylidene-2-Methylpropan-2-aMine oxide) inhibits COX2 catalytic activity.Formule :C11H15NODegré de pureté :99.46% - 99.84%Couleur et forme :SolidMasse moléculaire :177.24(E/Z)-BIX 02189
CAS :<p>BIX02189 is a selective inhibitor of MEK5 with IC50 of 1.5 nM.</p>Formule :C27H28N4O2Degré de pureté :98% - 99.89%Couleur et forme :SolidMasse moléculaire :440.54Pluripotin
CAS :<p>Pluripotin (SC1) (SC1), which keep embryonic stem cell (ESC) self-renewal, is a dual inhibitor of extracellular signal-regulated kinase 1 (ERK1, MAPK3) and</p>Formule :C27H25F3N8O2Degré de pureté :98.77% - 98.82%Couleur et forme :SolidMasse moléculaire :550.53Tenuifoliside A
CAS :<p>Tenuifoliside A has anti-apoptotic , neuroprotective activity.</p>Formule :C31H38O17Degré de pureté :98.99% - 99.91%Couleur et forme :SolidMasse moléculaire :682.62BAY885
CAS :<p>BAY885 is a new ERK5 inhibitor.</p>Formule :C25H28F3N7O2Degré de pureté :99.83%Couleur et forme :SolidMasse moléculaire :515.53Mogrol
CAS :<p>Mogrol, a biometabolite of mogrosides, functions by inhibiting the ERK1/2 and STAT3 pathways, diminishing CREB activation, and activating AMPK signaling.</p>Formule :C30H52O4Degré de pureté :99.85% - 99.90%Couleur et forme :SolidMasse moléculaire :476.73Temuterkib
CAS :<p>LY3214996 (Temuterkib) is a potent oral ERK1/2 inhibitor with potential cancer-fighting properties.</p>Formule :C22H27N7O2SDegré de pureté :99.57% - >99.99%Couleur et forme :SolidMasse moléculaire :453.56ERK5-IN-1
CAS :<p>ERK5-IN-1 is a potent ERK5 inhibitor (IC50: 87 nM). It also inhibits LRRK2[G2019S] (IC50: 26 nM).</p>Formule :C25H29N7O2Degré de pureté :97.70%Couleur et forme :SolidMasse moléculaire :459.54Tauroursodeoxycholate
CAS :<p>Tauroursodeoxycholate (UR 906), a hydrophilic bile acid, low in humans, may treat PBC, insulin resistance, and ALS.</p>Formule :C26H45NO6SDegré de pureté :98.77% - 99.93%Couleur et forme :White SolidMasse moléculaire :499.7Loureirin B
CAS :<p>Loureirin B suppresses fibrosis by modulating MMPs/TIMPs, hindering fibroblast growth, and targeting TGF-β1/Smad2/3 pathway.</p>Formule :C18H20O5Degré de pureté :99.33% - 99.86%Couleur et forme :SolidMasse moléculaire :316.35UNC569
CAS :<p>UNC569 selectively inhibits kidney URAT1, regulating uric acid excretion and aiding gout patient's uric balance.</p>Formule :C22H29FN6Degré de pureté :98.91% - 99.67%Couleur et forme :SolidMasse moléculaire :396.5DEL-22379
CAS :<p>DEL-22379 is a water-soluble ERK dimerization inhibitor with IC50 of ～0.5 μM.</p>Formule :C26H28N4O3Degré de pureté :99.3% - 99.53%Couleur et forme :SolidMasse moléculaire :444.532,5-Dihydroxyacetophenone
CAS :<p>2,5-Dihydroxyacetophenone has anti-anxiety, neuroprotective, anti-inflammatory properties, and modulates cell signaling and melanogenesis.</p>Formule :C8H8O3Degré de pureté :99.75%Couleur et forme :Yellow PowderMasse moléculaire :152.15Butein
CAS :Butein is a cAMP-specific PDE inhibitor, protein tyrosine kinase inhibitor, and SIRT1 activator.Cost-effective and quality-assured.Formule :C15H12O5Degré de pureté :98.76% - >99.99%Couleur et forme :SolidMasse moléculaire :272.25Pachymic acid
CAS :<p>Pachymic acid (3-O-Acetyltumulosic acid) is a natural product, and inhibits Akt and ERK signaling pathways.</p>Formule :C33H52O5Degré de pureté :99.43% - >99.99%Couleur et forme :White PowderMasse moléculaire :528.76β-Neoendorphin acetate(77739-21-0 free base)
CAS :<p>beta-Neoendorphin acetate is an agonist of κ-opioid receptor</p>Formule :C56H81N13O14Degré de pureté :99.91%Couleur et forme :SolidMasse moléculaire :1160.34GRK5-IN-2
CAS :<p>GRK5-IN-2, a pyridine-based bicyclic compound, is a potent G-protein-coupled receptor kinase 5 (GRK5) inhibitor.</p>Formule :C20H20N4O4Degré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :380.46-OAU
CAS :<p>6-OAU is a GPR84 agonist, activates it in HEK293 cells with a 105 nM EC50.</p>Formule :C12H21N3O2Degré de pureté :98.14% - 99.01%Couleur et forme :SolidMasse moléculaire :239.31Nitidine chloride
CAS :1.Formule :C21H18ClNO4Degré de pureté :96.59% - 99.55%Couleur et forme :SolidMasse moléculaire :383.82XMD17-109
CAS :<p>XMD17-109 (ERK5-IN-1) is a new selective ERK-5 inhibitor (EC50: 4.2 uM, HEK293 cells).</p>Formule :C36H46N8O3Degré de pureté :98.75% - 99.7%Couleur et forme :SolidMasse moléculaire :638.8A-674563 2HCl(552325-73-2(fb-2hcl))
<p>A-674563 2HCl is an Akt1 inhibitor with Ki of 11 nM, modest potent to PKA and >30-fold selective for Akt1 over PKC.</p>Formule :C22H24Cl2N4ODegré de pureté :94.66%Couleur et forme :SolidMasse moléculaire :431.36DCLK1-IN-1
CAS :<p>DCLK1-IN-1 is a selective, in vivo compatible chemical probe of the kinase domain of doublecortin-like kinase 1 (DCLK1).Cost-effective and quality-assured.</p>Formule :C26H28F3N7O2Degré de pureté :98.55% - 99.28%Couleur et forme :SolidMasse moléculaire :527.54AG126
CAS :AG126 (Tyrphostin AG126) selectively inhibits the phosphorylation of ERK1 (p44) and ERK2 (p42). AG-126 weakly inhibits epidermal GFRK and platelet-derived GFRK.Formule :C10H5N3O3Degré de pureté :97.35%Couleur et forme :SolidMasse moléculaire :215.16Epieriocalyxin A
CAS :<p>Epieriocalyxin A can suppress Caco-2 colon cancer cell growth. It could be a potential drug for colon cancer therapy in the future.</p>Formule :C20H24O5Degré de pureté :97.00%Couleur et forme :SolidMasse moléculaire :344.4DMU-212
CAS :<p>DMU-212, a Resveratrol derivative, has antimitotic, antiproliferative, antioxidant properties; induces apoptosis via ERK1/2.</p>Formule :C18H20O4Degré de pureté :99.86%Couleur et forme :SolidMasse moléculaire :300.35SUN11602
CAS :<p>SUN11602, an aniline compound, mimics the neuroprotective mechanisms of basic fibroblast growth factor.</p>Formule :C26H37N5O2Degré de pureté :99.36%Couleur et forme :SolidMasse moléculaire :451.6RU-301
CAS :<p>RU-301 is a novel pan-tam inhibitor</p>Formule :C21H19F3N4O4SDegré de pureté :98.87%Couleur et forme :SolidMasse moléculaire :480.46ERK-IN-3
CAS :<p>ERK-IN-3 (ASN007 free base) is a potent and orally active inhibitor of ERK.</p>Formule :C22H25ClFN7O2Degré de pureté :99.55% - 99.76%Couleur et forme :SolidMasse moléculaire :473.93Methylnissolin
CAS :<p>Methylnissolin (3-Hydroxy-9,10-dimethoxyptercarpan) is derived from Astragalus and has antibacterial and anti-cancer effects.</p>Formule :C17H16O5Degré de pureté :99.68% - 99.98%Couleur et forme :SolidMasse moléculaire :300.31EF24
CAS :<p>EF24 treatment boosts caspase 3/9 activity, hinders MEK1/ERK phosphorylation, and exhibits strong anti-tumor effects in OSCC by deactivating MAPK/ERK.</p>Formule :C19H15F2NODegré de pureté :99.71%Couleur et forme :SolidMasse moléculaire :311.33Deltonin
CAS :<p>Deltonin inhibits ERK1/2 & AKT; toxic to HepG2 (IC50: 7.66μM), C26 (IC50: 1.22μM), MDA-MB-231 cells (IC50: 1.58μM).</p>Formule :C45H72O17Degré de pureté :98.77% - 99.79%Couleur et forme :SolidMasse moléculaire :885.04trans-Zeatin
CAS :<p>trans-Zeatin ((E)-Zeatin) is the member of the plant growth hormone family known as cytokinins, which regulate cell division, development, and nutrient</p>Formule :C10H13N5ODegré de pureté :97.13% - 98.96%Couleur et forme :White To Light Yellow Crystal PowderMasse moléculaire :219.24Ravoxertinib
CAS :<p>Ravoxertinib (GDC-0994) is an effective and orally available ERK1/2 inhibitor (IC50: 1.1/0.3 nM).</p>Formule :C21H18ClFN6O2Degré de pureté :98% - 99.87%Couleur et forme :SolidMasse moléculaire :440.86Bohemine
CAS :<p>Bohemine is a cyclin-dependent kinase inhibitor.</p>Formule :C18H24N6ODegré de pureté :99.09% - 99.53%Couleur et forme :SolidMasse moléculaire :340.42Prosaptide TX14(A) acetate
<p>Prosaptide TX14(A) acetate is a potent GPR37L1 and GPR37 agonist. Prosaptide Tx14(A) TFA increases both ERK1 and ERK2 phosphorylation in Schwann cells.</p>Formule :C71H114N16O28Degré de pureté :95.29%Couleur et forme :SolidMasse moléculaire :1639.76Tauroursodeoxycholate sodium
CAS :<p>Tauroursodeoxycholate sodium (TUDC) is an endoplasmic reticulum (ER) stress inhibitor, used for the treatment of gallstones and liver cirrhosis.</p>Formule :C26H44NNaO6SDegré de pureté :97.90%Couleur et forme :SolidMasse moléculaire :521.69FR 180204
CAS :<p>FR 180204 is a potent and selective ATP-competitive inhibitor of ERK1 and ERK2.</p>Formule :C18H13N7Degré de pureté :98% - 99.74%Couleur et forme :SolidMasse moléculaire :327.34MRTX1133
CAS :<p>View and buy MRTX1133 from TargetMol.MRTX1133 is a potent, selective, and noncovalent inhibitor of KRAS G12D.</p>Formule :C33H31F3N6O2Degré de pureté :97.39% - 99.6%Couleur et forme :SolidMasse moléculaire :600.63KO-947
CAS :<p>KO-947 is a potent and specific inhibitor of ERK1/2 kinases.</p>Formule :C21H17N5ODegré de pureté :97.84%Couleur et forme :SolidMasse moléculaire :355.39LM22B-10
CAS :<p>LM22B-10 is an activator of TrkB/TrkC neurotrophin receptor and can induce TrkB, TrkC, ERK and AKT activation in vitro and in vivo.</p>Formule :C27H33ClN2O4Degré de pureté :98.18%Couleur et forme :SolidMasse moléculaire :485.01AZD8330
CAS :<p>AZD8330 (ARRY-704) is a novel, selective, non-ATP competitive MEK 1/2 inhibitor with IC50 of 7 nM. Phase 1.</p>Formule :C16H17FIN3O4Degré de pureté :98.72%Couleur et forme :SolidMasse moléculaire :461.23Tizaterkib
CAS :<p>Tizaterkib (AZD-0364) is a potent and selective ERK2 inhibitor.</p>Formule :C24H24F2N8O2Degré de pureté :99.6% - 99.63%Couleur et forme :SolidMasse moléculaire :494.5ERK-IN-4
CAS :<p>ERK-IN-4 is a cell-permeable ERK inhibitor with potential antiproliferative effects for the study of diseases caused by immune dysfunction.</p>Formule :C14H17ClN2O3SDegré de pureté :98.92% - 99.84%Couleur et forme :SolidMasse moléculaire :328.814Ulixertinib hydrochloride
CAS :<p>Ulixertinib hydrochloride (Ulixertinib HCl) is an ERK1/2 inhibitor with anticancer and antitumor activity that inhibits the NB cell cycle and promotes apoptosis</p>Formule :C21H23Cl3N4O2Degré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :469.79CAY10561
CAS :<p>CAY10561: potent, selective ERK2 inhibitor (Ki=2nM); blocks cell proliferation; IC50 in COLO 205 cells: 0.54μM.</p>Formule :C22H17Cl2FN4O2Couleur et forme :SolidMasse moléculaire :459.3GP17
CAS :<p>GP17 is a type II kinase inhibitor of the IRE1α endoribonuclease that acts by targeting the ATP-binding pocket of IRE1α.</p>Formule :C26H21F3N4OCouleur et forme :SolidMasse moléculaire :462.47UC-857993
CAS :<p>UC-857993 is a selective SOS1-Ras inhibitor with a Kd of 14.7 μM that inhibits ERK, Ras, and reduces MEF growth.</p>Formule :C25H22ClNO2Couleur et forme :SolidMasse moléculaire :403.9BNC-1
CAS :<p>BNC-1 reduces amyloid in mice, enhances synapses by activating Elk-1.</p>Formule :C16H14N2O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :282.29mSIRK
CAS :<p>mSIRK (G-Protein βγ Binding Peptide) is an ERK1 and ERK2 dual activator that promotes alpha-subunit dissociation.</p>Formule :C93H150N20O25Degré de pureté :99.26%Couleur et forme :SolidMasse moléculaire :1948.31Dihydrolipoic acid
CAS :<p>Dihydrolipoic acid (USAF XR-12), a dithiol carboxylic acid, is a potent antioxidant active against various reactive oxygen species at 0.01-0.5 mM.</p>Formule :C8H16O2S2Degré de pureté :97.51%Couleur et forme :Yellow To Orange LiquidMasse moléculaire :208.34ERK5-IN-4
CAS :<p>ERK5-IN-4 (34b) is a potent, specific ERK5 inhibitor; IC50: 77 nM full-length, 300 nM ΔTAD in HEK293 cells.</p>Formule :C16H11Cl2FN4O2Couleur et forme :SolidMasse moléculaire :381.19PERK-IN-3
CAS :<p>PERK-IN-3 is a potent inhibitor of PERK(IC50 of 7.4 nM).</p>Formule :C22H16F2N4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :406.38ADTL-EI1712
CAS :<p>ADTL-EI1712: ERK1/2/5 inhibitor (ERK1 IC50=40.43nM, ERK5=64.5nM), blocks HL-60/MKN74 cell growth, not HeLa; effective in MKN74 mouse model.</p>Formule :C22H18Cl2N4O2S2Couleur et forme :SolidMasse moléculaire :505.44ERK1/2 inhibitor 1
CAS :<p>ERK1/2 inhibitor 1 is a potent, orally bioavailable ERK1/2 inhibitor, showing 60% inhibition at 1 nM and an IC50 of 3.0 nM against ERK1 and ERK2, respectively.</p>Formule :C29H32ClN5O4Degré de pureté :98.81%Couleur et forme :SolidMasse moléculaire :550.052,5-Dihydroxybiphenyl
CAS :<p>2,5-Dihydroxybiphenyl: a small molecule that induces trichothiodystrophy A protein dimerization, modulating TFIIH activity.</p>Formule :C12H10O2Degré de pureté :99.66%Couleur et forme :White To Grey-Brownish PowderMasse moléculaire :186.21ERK5-IN-3
CAS :<p>ERK5-IN-3 inhibits ERK5 strongly (IC50: 6 nM) and hampers Hela cell growth (IC50: 31 nM).</p>Formule :C24H23Cl2FN4O2Couleur et forme :SolidMasse moléculaire :489.37GABAB receptor antagonist 1
CAS :(E)-GABAB receptor antagonist 1 decreases GABA-induced IP3 (inositol trisphosphate) production with IC50 of 37.9 μM.GABAB receptor antagonist 1 is a selectiveFormule :C18H24O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :304.38Migoprotafib
CAS :Migoprotafib (GDC-1971) is a potent and highly selective SHP2 (Src Homology-2 Domain-Containing Phosphatase 2) inhibitor for advanced solid tumours.Formule :C25H26N8OCouleur et forme :SolidMasse moléculaire :454.53NMDAR/TRPM4-IN-2
CAS :<p>Potent NMDAR/TRPM4-IN-2 blocks NMDAR/TRPM4, protects brain and retinal neurons, and prevents mitochondrial dysfunction with an IC50 of 2.1 μM.</p>Formule :C11H19BrCl2N2Degré de pureté :98.77%Couleur et forme :SolidMasse moléculaire :330.092(E)-GABAB receptor antagonist 1
CAS :<p>(E)-GABAB antagonist 1 inhibits GABA IP3 production, with an IC50 of 37.9 μM and acts as a selective negative modulator.</p>Formule :C18H24O4Degré de pureté :98.09%Couleur et forme :SolidMasse moléculaire :304.38RLX-33
CAS :<p>RLX-33 blocks RXFP3 and relaxin 3 effects, controls food intake in rats, and may help study metabolic syndrome.</p>Formule :C24H19ClN4O4Degré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :462.89ZINC12409120
CAS :<p>ZINC12409120 (R-4584) is a selective ERK inhibitor.ZINC12409120 inhibits ERK with an IC50 of 5.0 μM.ZINC12409120 inhibits ERK activity by interfering with FGF23</p>Formule :C20H16N4O2Degré de pureté :99.71% - 99.95%Couleur et forme :SolidMasse moléculaire :344.37ERK1/2 inhibitor 8
CAS :<p>ERK1/2 inhibitor 8 is a potent inhibitor of ERK that acts on ERK2 (IC50: 0.48 nM).</p>Formule :C23H20ClN7O2SCouleur et forme :SolidMasse moléculaire :493.97ERK1/2 inhibitor 5
CAS :ERK1/2 inhibitor 5: potent against ERK1/2, may combat cancer and inflammation.Formule :C28H32ClFN6O5Couleur et forme :SolidMasse moléculaire :587.04ERK1/2 inhibitor 9
CAS :<p>ERK1/2 Inhibitor 9 (Probe 1), a covalent antagonist of ERK1/2, exhibits sub-micromolar efficacy in cellular assays (A375 GI50=0.47 μM) and facilitates the</p>Formule :C31H32ClN7O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :586.08ERK Inhibitor II (Negative control)
CAS :<p>ERK Inhibitor II, a control, blocks ERK and insulin receptor activation, aiding diabetes research.</p>Formule :C18H12N6OCouleur et forme :SolidMasse moléculaire :328.33MRS2693 trisodium
CAS :<p>MRS2693 trisodium, a selective P2Y6 agonist with an EC50 of 0.015 μM, demonstrates cytoprotective effects in a mouse hindlimb skeletal muscle ischemia-reperfusion injury model by reducing NF-kappaB activation and stimulating the ERK1/2 pathway [1] [2].</p>Formule :C9H10IN2Na3O12P2Couleur et forme :SolidMasse moléculaire :596Laxiflorin B
CAS :<p>Laxiflorin B, a novel selective inhibitor of ERK 1/2 derived from herbal sources, exhibits antitumor activity [1].</p>Formule :C20H24O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :344.4MEK-IN-6
CAS :<p>MEK-IN-6 (Example 69), a potent MEK inhibitor, effectively inhibits ERK1/2 (Thr202/Tyr204) phosphorylation in A375 cells, with an IC50 of 2 nM, making it</p>Formule :C18H20FN3O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :393.43KRAS G12C inhibitor 61
CAS :<p>KRAS G12C inhibitor 61 (Example 3) demonstrates potent activity by inhibiting phospho-ERK 1/2 in MIA PaCa-2 cells, reflected in an IC50 value of 9 nM.</p>Formule :C31H33ClFN7O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :590.09K145 hydrochloride
CAS :<p>K145 hydrochloride is a selective sphk2 inhibitor with substrate competitiveness and oral activity, with IC50 of 4.3 µM and Ki of 6.4 µM.</p>Formule :C18H25ClN2O3SDegré de pureté :99.8%Couleur et forme :SolidMasse moléculaire :384.92(R)-VX-11e
CAS :<p>(R)-VX-11e is an isomer of VX-11e, a potent and selective ERK2 inhibitor with potential to inhibit tumor growth.</p>Formule :C24H20Cl2FN5O2Degré de pureté :98.73%Couleur et forme :SolidMasse moléculaire :500.35DL-threo dihydrosphingosine
CAS :<p>DL-threo dihydrosphingosine blocks ERK, inhibits smooth muscle proliferation, and works against growth factor/G-protein ERK activation.</p>Formule :C18H39NO2Couleur et forme :SolidMasse moléculaire :301.51Inflachromene
CAS :Inflachromene (ICM) is an inhibitor of HMGB1 and HMGB expression with anti-inflammatory activity.Inflachromene is used in the study of epilepsy.Formule :C21H19N3O4Degré de pureté :97.36% - 99.88%Couleur et forme :SolidMasse moléculaire :377.39CXJ-2
CAS :<p>CXJ-2, a cyclic peptide, binds EDPs, inhibits PI3K/ERK, and reduces hepatic cell growth/migration, offering antifibrotic effects.</p>Formule :C55H87N15O22Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1310.37I-287
CAS :<p>I-287 is a selective, orally active PAR2 inhibitor that functions as a negative allosteric modulator of Gαq and Gα12/13 activity and their downstream effectors.</p>Formule :C30H30ClFN4O4Couleur et forme :SolidMasse moléculaire :565.04ERK1/2 inhibitor 7
CAS :<p>ERK1/2 inhibitor 7 is a potent inhibitor of ERK, acting on ERK2 (IC50: 0.94 nM).</p>Formule :C23H22FN7OSCouleur et forme :SolidMasse moléculaire :463.53EVT801
CAS :<p>EVT801 is a highly selective and low-toxic VEGFR-3 inhibitor that inhibits VEGF-C-induced tumor lymphoid and angiogenesis and reduces CCL4, CCL5 and MDSC.</p>Formule :C19H21N5O3Degré de pureté :97.4%Couleur et forme :SolidMasse moléculaire :367.4ERK-IN-2 free base
CAS :<p>ERK-IN-2 free base inhibits ERK2 (IC50: 1.8 nM); potential off-target effects at >10 μM.</p>Formule :C16H17N5O2Couleur et forme :SolidMasse moléculaire :311.34JWG-071
CAS :<p>JWG-071: First ERK5 kinase probe, BET inhibitor, 1 μM BRD4 IC, boosts ERK5 function and BRD4 selectivity.</p>Formule :C34H44N8O3Degré de pureté :98.33%Couleur et forme :SolidMasse moléculaire :612.77MK-8353
CAS :<p>MK-8353 (SCH900353) is a potent, selective and orally available inhibitor of ERK1/2 (IC50s of 23.0 nM and 8.8 nM, respectively)</p>Formule :C37H41N9O3SDegré de pureté :96.15% - 97.19%Couleur et forme :SolidMasse moléculaire :691.84ERK1/2 inhibitor 6
CAS :<p>ERK1/2 inhibitor 6 - potent cancer/inflammation treatment from WO2021063335A1.</p>Formule :C27H29ClFN7O5Couleur et forme :SolidMasse moléculaire :586.01Coelogin
CAS :<p>Coelogin is an orally effective bone-protective agent that activates ER-Erk and Akt-dependent signaling pathways, thereby stimulating osteoblast differentiation. It is utilized in osteoporosis research.</p>Formule :C17H16O5Couleur et forme :SolidMasse moléculaire :300.31ERK2 IN-1
CAS :<p>ERK2 IN-1 is a selective ERK2 inhibitor with an IC50 of 7 nM.</p>Formule :C36H34FN7O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :647.76ATX inhibitor 26
CAS :<p>ATX inhibitor 26 is an Autotaxin (ATX) inhibitor with an IC50 of 57 nM in human plasma. It effectively inhibits cell migration and collagen gel contraction. Additionally, ATX inhibitor 26 demonstrates significant antifibrotic activity, reducing collagen deposition in a Bleomycin (BLM)-induced pulmonary fibrosis model.</p>Formule :C18H19Cl2N7O3Couleur et forme :SolidMasse moléculaire :452.30DOR agonist 2
CAS :<p>Compound 3 (DOR agonist 2) acts as a Delta Opioid Receptor agonist. It inhibits the expression of TNF-α, obstructs NF-κB transportation to the nucleus, and activates the G protein-mediated ERK1/2 pathway. This compound is useful for research into neurodegenerative diseases.</p>Formule :C29H26N2O3Couleur et forme :SolidMasse moléculaire :450.53AL 8810
CAS :<p>AL-8810 is an 11β-fluoro analog of PGF 2α with selective antagonist effects at the PGF 2α receptor (FP receptor) [1].</p>Formule :C24H31FO4Couleur et forme :SolidMasse moléculaire :402.5SOS1 activator 2
CAS :<p>SOS1 activator 2 (Compound 65) is a benzothiazole derivative and an activator of SOS1. It demonstrates a high binding affinity for SOS1, with a Kd of 9 nM. By modulating the Ras-ERK signaling pathway, SOS1 activator 2 is suitable for tumor research.</p>Formule :C26H28ClFN6Couleur et forme :SolidMasse moléculaire :478.992KRASG12C IN-15
CAS :<p>KRASG12C IN-15 (Compound 21) is an orally active KRASG12C inhibitor that effectively blocks SOS1-mediated GDP/GTP exchange with an IC50 of 19 nM. It inhibits ERK phosphorylation with an IC50 of 0.051 μM and reduces the viability of KRASG12C mutant MIA PaCa-2 cells with an IC50 of 0.023 μM. Additionally, KRASG12C IN-15 demonstrates antitumor activity in a MIA PaCa-2 xenograft mouse model.</p>Formule :C31H32FN3O2Couleur et forme :SolidMasse moléculaire :497.603(rel)-AR234960
CAS :(rel)-AR234960 is an active relative configuration of AR234960. AR234960 is a non-peptide agonist of MAS.Formule :C27H30FN5O5SCouleur et forme :SolidMasse moléculaire :555.63ERK-IN-2
CAS :<p>ERK-IN-2, an ERK2 inhibitor, exhibits an IC50 value of 1.8 nM. At doses greater than 10 μM, it may induce off-target toxicity and/or activity [1].</p>Formule :C16H18ClN5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :347.80Hypothemycin
CAS :<p>Hypothemycin, a fungal polyketide, inhibits multiple kinases (VEGFR, MEK, FLT-3, PDGFR, ERK) with Kis ranging from 10 nM to 2.4 μM.</p>Formule :C19H22O8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :378.37MAP855
CAS :<p>MAP855: potent, selective, oral MEK1/2 inhibitor; IC50=3 nM, pERKEC50=5 nM; effective on wild-type/mutant MEK1/2.</p>Formule :C28H23ClF2N6O3Couleur et forme :SolidMasse moléculaire :564.97SHR2415
<p>SHR2415: Potent, selective ERK1/2 inhibitor, oral; ERK1 IC50: 2.8 nM, ERK2 IC50: 5.9 nM; effective in Colo205 (IC50: 44.6 nM), for cancer research.</p>Formule :C23H22ClN7O2Couleur et forme :SolidMasse moléculaire :463.92KU004
CAS :<p>KU004, a potent dual EGFR/HER2 inhibitor, exhibits anticancer properties. It inhibits the proliferation of human breast cancer SKBR3 cells by inducing G1 phase arrest. KU004 blocks the activation of HER2, EGFR, and the downstream Akt and Erk pathways, primarily inducing apoptosis (Apoptosis) through the extrinsic pathway. Additionally, KU004 is a novel quinazoline derivative.</p>Formule :C29H27ClFN4O2PCouleur et forme :SolidMasse moléculaire :548.98KRAS inhibitor-27
CAS :<p>KRAS inhibitor-27 (Compound 15h) is a KRAS inhibitor that effectively targets KRAS G12D/G12V mutated cells (AsPC-1 and SW620) and wild-type KRAS cells (HT-29), with IC50 values of 378 nM, 0.6 nM, and 3230 nM, respectively. It reduces ERK phosphorylation, with IC50 values of 0.6 nM and 1 nM in AsPC-1 and SW620 cells, respectively, and decreases DUSP4 expression, thereby inhibiting the MAPK signaling pathway.</p>Formule :C31H28ClF3N6O3SCouleur et forme :SolidMasse moléculaire :657.106Rineterkib
CAS :Rineterkib (ERK-IN-1) is an inhibitor of RAF and ERK1/2 activating mutations in the MAPK pathway.Formule :C26H27BrF3N5O2Degré de pureté :99.73%Couleur et forme :SolidMasse moléculaire :578.42Omtriptolide
CAS :<p>Omtriptolide, triptolide purified from the Chinese herb, is a water-soluble derivative prodrug.</p>Formule :C24H28O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :460.479Ravoxertinib hydrochloride
CAS :<p>Ravoxertinib hydrochloride is an orally bioavailable and selective inhibitor for ERK kinase activity (IC50: 6.1 nM and 3.1 nM for ERK1 and ERK2, respectively).</p>Formule :C21H19Cl2FN6O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :477.32Pamoic acid
CAS :<p>Pamoic acid is the orphan G protein-coupled receptor GPR35 agonist. Pamoic acid activates ERK and beta-arrestin2 and causes antinociceptive activity.</p>Formule :C23H16O6Degré de pureté :99.99%Couleur et forme :Fine Yellow PowderMasse moléculaire :388.37WQ-C-401
CAS :<p>WQ-C-401 is an orally active inhibitor of the platelet-derived growth factor receptor (PDGFR). It inhibits cell proliferation by blocking PDGFR auto-phosphorylation in a concentration-dependent manner, with EC50 values of 3.5 nM for PDGFRαY849 and 5.8 nM for PDGFRβY1021. Additionally, WQ-C-401 suppresses the proliferation and migration of PASMCs by inhibiting PDGF-BB-induced phosphorylation of ERK1/2, reduces collagen I synthesis, and increases α-SMA expression, thereby preventing pulmonary vascular remodeling. This compound shows promise for research in the field of pulmonary arterial hypertension.</p>Formule :C24H26N4O3Couleur et forme :SolidMasse moléculaire :418.49
