Raf
Les kinases Raf sont des composants clés de la voie de signalisation MAPK/ERK, jouant un rôle critique dans la transmission des signaux de la membrane cellulaire au noyau. L'activation de Raf conduit à la phosphorylation de MEK, qui active ensuite ERK, influençant ainsi la division cellulaire, la différenciation et la survie. Les mutations de Raf, en particulier dans B-Raf, sont associées à divers cancers, ce qui fait de Raf une cible cruciale en thérapie anticancéreuse. Chez CymitQuimica, nous offrons une variété d'inhibiteurs et de modulateurs de Raf pour soutenir vos recherches en oncologie, transduction de signaux et développement thérapeutique.
81 produits trouvés pour "Raf".
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AZ 628
CAS :AZ628 is a new pan-Raf inhibitor for BRAF, BRAFV600E, and c-Raf-1 with IC50 of 105 nM, 34 nM and 29 nM, also inhibits VEGFR2, DDR2, Lyn, Flt1, FMS, etc.Formule :C27H25N5O2Degré de pureté :99.50%Couleur et forme :SolidMasse moléculaire :451.52Raf inhibitor 1 dihydrochloride
CAS :Raf inhibitor 1 dihydrochloride (B-Raf inhibitor 1 dihydrochloride) is a potent and selective B-Raf inhibitor.Formule :C26H19ClN8HClDegré de pureté :98.19% - 99.54%Couleur et forme :SolidMasse moléculaire :551.86Raf inhibitor 1
CAS :B-Raf inhibitor 1 (B-Raf inhibitor 1) is a potent and selective B-Raf inhibitor.Formule :C26H19ClN8Degré de pureté :99.91%Couleur et forme :SolidMasse moléculaire :478.94TBAP-001
CAS :TBAP-001 is a RAF kinase inhibitor, with an IC50 of 62 nM in BRAF V600E kinase assay and an IC50 of 18 nM in Cell-Based Phosho-ERK Assay.Formule :C27H23F2N7O3Degré de pureté :99.28% - 99.58%Couleur et forme :Yellow SolidMasse moléculaire :531.51Ref: TM-T9693
1mg46,00€5mg92,00€1mL*10mM (DMSO)107,00€10mg147,00€25mg258,00€50mg386,00€100mg537,00€200mg710,00€PLX7904
CAS :PLX7904 (PB04), a selective RAF inhibitor, blocks ERK1/2 in mutant BRAF melanoma without activating it in RAS mutants.Formule :C24H22F2N6O3SDegré de pureté :99.51% - 99.66%Couleur et forme :SolidMasse moléculaire :512.53RAF-IN-1
CAS :RAF-IN-1 inhibits cRAF, BRAF and BRAFV600E, with GI50 3.4 and 2.9 nM in mutant cell lines.Formule :C26H22F3N3O4Degré de pureté :99.62%Couleur et forme :White SolidMasse moléculaire :497.47BRAF inhibitor
CAS :BRAF inhibitor is an inhibitor of B-Raf.Formule :C22H18F2N4O3SDegré de pureté :98.2% - 98.41%Couleur et forme :SolidMasse moléculaire :456.47Ref: TM-T10599
1mg44,00€5mg87,00€1mL*10mM (DMSO)99,00€10mg137,00€25mg236,00€50mg371,00€100mg530,00€200mg770,00€MCP110
CAS :MCP110 is an inhibitor of the interaction of Ras with Raf-1 and can be used in studies about the treatment of human tumors.Formule :C33H36N2O3Degré de pureté :97.23%Couleur et forme :OilMasse moléculaire :508.65Ref: TM-T24437
1mg34,00€5mg92,00€1mL*10mM (DMSO)103,00€10mg160,00€25mg276,00€50mg400,00€100mg532,00€500mg1.063,00€B-Raf IN 13
CAS :B-Raf IN 13 is a potent B-Raf inhibitor with anticancer activity.B-Raf IN 13 has an IC50 of 3.55 nM in the BRAF V600E enzyme assay.Formule :C19H19ClFN3O4SDegré de pureté :99.41% - >99.99%Couleur et forme :SolidMasse moléculaire :439.89GDC-0879
CAS :GDC-0879 (AR-00341677) is a novel, potent and selective B-Raf inhibitor with IC50 of 0.13 nM with activity against c-Raf as well.Formule :C19H18N4O2Degré de pureté :99.62%Couleur et forme :SolidMasse moléculaire :334.37Ref: TM-T6320
1mg35,00€2mg50,00€5mg74,00€1mL*10mM (DMSO)82,00€10mg105,00€25mg205,00€50mg334,00€100mg537,00€200mg765,00€GSK2008607
CAS :GSK2008607 is a potent B-RafV600E inhibitor with anticancer activity and can be used to study breast, colorectal, melanoma, thyroid, and ovarian cancers.Formule :C31H28F3N7O3S2Degré de pureté :99.99%Couleur et forme :SolidMasse moléculaire :667.72Ref: TM-T27454
1mg315,00€5mg745,00€10mg1.018,00€25mg1.431,00€50mg1.783,00€100mg2.250,00€500mg4.410,00€SOS1-IN-15
CAS :SOS1-IN-15 is an orally active and potent SOS1 inhibitor with potential antitumor activity.SOS1-IN-15 is used in the study of colon cancer.Formule :C28H27F3N6O2Degré de pureté :98.32%Couleur et forme :SolidMasse moléculaire :536.548Lifirafenib
CAS :Lifirafenib (Beigene-283) is a potent inhibitor of RAF family kinases and EGFR in biochemical assays with IC50 of 23, 29 and 495 nM for the recombinantFormule :C25H17F3N4O3Degré de pureté :97.99% - 98%Couleur et forme :SolidMasse moléculaire :478.42Ref: TM-T22272
50mgÀ demander100mgÀ demander1mg34,00€5mg65,00€10mg92,00€1mL*10mM (DMSO)94,00€25mg180,00€B-Raf IN 15
CAS :B-Raf IN 15 is a BRAF inhibitor that inhibits BRAFWT and BRAFV600E and can be used to study melanoma and cancer.Formule :C19H15N3OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :333.41Uplarafenib
CAS :Uplarafenib (B-Raf IN 10), a potent BRAF inhibitor (IC50: 50-100 nM), exhibits antitumor effects on solid cancers.Formule :C22H21F3N4O4SDegré de pureté :99.98%Couleur et forme :SolidMasse moléculaire :494.49Ref: TM-T63333
1mg54,00€5mg119,00€1mL*10mM (DMSO)131,00€10mg170,00€25mg359,00€50mg538,00€100mg928,00€B-Raf IN 16
CAS :B-Raf IN 16, a BRAF inhibitor, belongs to cyclic iminopyrimidine derivatives and can be used for cancer or tumour research.Formule :C20H19N5O3SDegré de pureté :99.31% - 99.78%Couleur et forme :SolidMasse moléculaire :409.46Raf inhibitor 3
CAS :Raf inhibitor 3 (Example 30), a potent inhibitor of both B-Raf and C-Raf, exhibits IC50 values below 15 nM. It is applicable in cancer research studies [1].Formule :C18H19FN8O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :430.46HG6-64-1
CAS :HG6-64-1 (HMSL 10017-101-1, compound 9 (XI-1)) is a potent and selective B-Raf inhibitor with an IC50 = 0.09 μM in B-raf V600E-transformed Ba/F3 cells.Formule :C32H34F3N5O2Degré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :577.64Ref: TM-T15480
1mg69,00€5mg147,00€1mL*10mM (DMSO)178,00€10mg215,00€25mg371,00€50mg522,00€100mg708,00€Brimarafenib
CAS :Brimarafenib is a selective RAF dimerization inhibitor, which can inhibit BRAF and CRAF, and exhibits inhibitory effects on a variety of RAF mutations.Formule :C24H17F3N4O4Degré de pureté :98.32%Couleur et forme :White SolidMasse moléculaire :482.41pan-Raf/RTK inhibitor 1
CAS :Pan-Raf/RTK inhibitor 1 (compound I-16) is a potent pan-Raf inhibitor with IC50 values of 3.49 nM (BRafV600E), 8.86 nM (ARaf), 5.78 nM (BRafWT), and 1.65 nM (CRaf). It exhibits antiproliferative activity against various cancer cell lines and can be utilized in cancer research.Formule :C29H28F3N7O3Couleur et forme :SolidMasse moléculaire :579.573
