Transporteur membranaire/Canal ionique
Les inhibiteurs des transporteurs membranaires et des canaux ioniques sont des composés qui bloquent la fonction des protéines responsables du transport des ions, des nutriments et d'autres molécules à travers les membranes cellulaires. Ces inhibiteurs sont essentiels pour étudier la régulation de l'homéostasie cellulaire, la transduction des signaux et la neurotransmission. Les inhibiteurs des transporteurs membranaires et des canaux ioniques sont également importants pour développer des traitements contre des troubles tels que l'épilepsie, les maladies cardiovasculaires et les syndromes métaboliques. Chez CymitQuimica, nous offrons une sélection diversifiée d'inhibiteurs de haute qualité des transporteurs membranaires et des canaux ioniques pour soutenir vos recherches en physiologie, neurosciences et pharmacologie.
Sous-catégories appartenant à la catégorie "Transporteur membranaire/Canal ionique"
- ABC(3 produits)
- ATPase(93 produits)
- Récepteur de l'adiponectine(5 produits)
- CFTR(64 produits)
- Récepteur CGRP(51 produits)
- Canal calcique(493 produits)
- Canal chlorure(49 produits)
- Récepteur GABA(336 produits)
- Transporteur de monoamine(23 produits)
- Transporteur de monocarboxylate(17 produits)
- NKCC(2 produits)
- NPC1L1(3 produits)
- Cotransporteur Na-K-Cl(8 produits)
- OAT(27 produits)
- OCT(7 produits)
- P-gp(53 produits)
- Canal potassique(276 produits)
- Pompe à protons(39 produits)
- SGLT(30 produits)
- Canal sodique(202 produits)
- Canal TRP/TRPV(92 produits)
Affichez 13 plus de sous-catégories
2270 produits trouvés pour "Transporteur membranaire/Canal ionique"
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Unoprostone isopropyl
CAS :<p>Unoprostone isopropyl, a prostanoid and synthetic docosanoid, is approved for the treatment of ocular hypertension and open-angle glaucoma.</p>Formule :C25H44O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :424.618-Prenylchrysin
CAS :<p>8-Prenylchrysin is a C8-isopentenyl flavonoid compound. It acts as an inhibitor of P-glycoprotein (P-gp) and can be utilized in cancer research.</p>Formule :C20H18O4Couleur et forme :SolidMasse moléculaire :322.354(RS)-AMPA monohydrate
CAS :<p>(RS)-AMPA monohydrate, potent glutamate analogue, selectively activates L-glutamic acid without affecting kainic acid or NMDA receptors.</p>Formule :C7H12N2O5Couleur et forme :SolidMasse moléculaire :204.182Probenecid sodium
CAS :<p>Probenecid sodium is the sodium salt of Probenecid, a potent and selective agonist of transient receptor potential vanilloid 2 (TRPV2) channels. Additionally, Probenecid acts as an inhibitor of pannexin 1 channels.</p>Formule :C13H18NNaO4SCouleur et forme :SolidMasse moléculaire :307.341TRPC4/5-IN-1
<p>TRPC4/5-IN-1, a TRPC5/4 inhibitor with IC50s 0.54 μM/2.06 μM, targets skin inflammation and proteinuric kidney diseases.</p>Formule :C21H21N3OCouleur et forme :SolidMasse moléculaire :331.41hURAT1 inhibitor 2
CAS :<p>hURAT1 inhibitor 2 (Compound 5) is an inhibitor of hURAT1 (uric acid transporter 1, SLC22A12) with an IC50 of 18 nM. It also exhibits some inhibitory activity against OATP1B1, with an IC50 of 0.73 μM. hURAT1 inhibitor 2 can be used in research related to hyperuricemia, gout, and other diseases associated with abnormal uric acid metabolism.</p>Formule :C17H11Br2FO3Couleur et forme :SolidMasse moléculaire :442.074P-gp modulator 2
<p>P-gp modulator 2 (Compound 27) is a potent competitive and metabotropic P-glycoprotein (P-gp) modulator.</p>Formule :C22H20BrN3O4Couleur et forme :SolidMasse moléculaire :470.32GABAA receptor agonist 2
<p>Compound 4c, a potent GABAA agonist with anti-depressive effects in mouse FST/TST, shows promise in depression research.</p>Formule :C22H36O5Couleur et forme :SolidMasse moléculaire :380.52Dehydelone
CAS :<p>Dehydelone(KOS-1584, R-1645, SK-10088) is a microtubule stabilizer that may be used in the treatment of non-small cell lung cancer.</p>Formule :C27H39NO5SCouleur et forme :SolidMasse moléculaire :489.67P-gp inhibitor 2
CAS :<p>Potent P-gp inhibitor 2 reverses Doxorubicin resistance in colorectal carcinoma cells with IC50 of 0.22 µM.</p>Formule :C29H26N2O6Couleur et forme :SolidMasse moléculaire :498.53INCB-056868
CAS :<p>INCB-056868 is the metabolite M11 of Epacadostat. It serves as a substrate for BCRP and holds potential for use in the study of metabolic diseases.</p>Formule :C11H13BrFN7O3SCouleur et forme :SolidMasse moléculaire :422.23NMDA receptor antagonist-3
<p>NMDA antagonist-3: recovery rate 40% at 100 μM, low toxicity in SH-SY5Y, human stem cells.</p>Formule :C13H19N3O6Couleur et forme :SolidMasse moléculaire :313.31BMS-986163
CAS :<p>BMS-986163, a prodrug, quickly becomes BMS-986169, a GluN2B inhibitor (Ki=4 nM, IC50=24 nM).</p>Formule :C23H28FN2O5PDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :462.45Coleon-U-quinone
CAS :<p>Coleon-U-quinone, a P-gp inhibitor, reduces cancer cell viability and enhances Doxorubicin sensitivity in resistant cells.</p>Formule :C20H24O5Couleur et forme :SolidMasse moléculaire :344.4DFBTA
<p>DFBTA inhibits ANO1 with IC50 of 24 nM, effectively treating inflammatory pain orally.</p>Formule :C18H10ClF2NO3SCouleur et forme :SolidMasse moléculaire :393.79KCa2 channel modulator 2
<p>Compound 2q is a potent, subtype-selective K/Ca 2 modulator, effective on human K Ca 2.3 and rat K Ca 2.2a with EC50s of 0.60 μM and 0.64 μM.</p>Formule :C16H15ClFN5Couleur et forme :SolidMasse moléculaire :331.78TRPV1 antagonist 3
<p>TRPV1 antagonist 3 (7q) strongly blocks TRPV1 at 2.66 nM IC50, is selective, 60% bioavailable, and crosses the blood-brain barrier.</p>Formule :C23H25N3OSCouleur et forme :SolidMasse moléculaire :391.53Ro 0437626
CAS :<p>P2X1 purinergic receptor antagonist</p>Formule :C27H35N5O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :525.66NYX-2925
CAS :<p>NYX-2925, an oral NMDAR modulator, enhances Src in mPFC. No CAMKII impact or addictive/sedative effects. Useful for CNS disorder studies.</p>Formule :C14H23N3O4Couleur et forme :SolidMasse moléculaire :297.35(RS)-AMPA
CAS :<p>(RS)-AMPA ((±)-AMPA) is a glutamate analog. (RS)-AMPA is an agonist of effective and selective excitatory neurotransmitter L-glutamic acid.</p>Formule :C7H10N2O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :186.17Onfasprodil
CAS :<p>Onfasprodil, NR2B inhibitor & GABA regulator, potential for Alzheimer's research. (Patent CN111481543A)</p>Formule :C20H23FN2O3Couleur et forme :SolidMasse moléculaire :358.41Valbenazine tosylate
CAS :<p>Valbenazine tosylate, the tosylate salt of valbenazine, is a vesicular monoamine transporter 2 (VMAT2) inhibitor with a Ki value of 150 nM while displaying no</p>Formule :C38H54N2O10S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :762.974α-PDD
CAS :<p>4alpha-PDD activates transient receptor potential vanilloid 4 (TRPV4) channels and is inactive for signaling through PKC.</p>Formule :C40H64O8Couleur et forme :SolidMasse moléculaire :672.93DS88790512
CAS :<p>DS88790512, IC50 at 11 nM, is an effective, selective, oral bioeffective TRPC6 inhibitor.</p>Formule :C22H29N3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :367.48KPH2f
CAS :<p>KPH2f: dual URAT1/GLUT9 inhibitor, orally active, IC50: 0.24μM (URAT1), 9.37μM (GLUT9), minimal OAT1/ABCG2 impact.</p>Formule :C24H16N3NaO2SCouleur et forme :SolidMasse moléculaire :433.46Cav 3.2 inhibitor 3
<p>Cav 3.2 inhibitor 3 is a potent inhibitor of the Cav3.2 T-type Ca2+channel (IC50: 0.1534 μM) and has a low binding affinity for D2 receptors.</p>Formule :C32H37N3O2Couleur et forme :SolidMasse moléculaire :495.66P-gp modulator 1
CAS :<p>P-gp modulator 1 is a high affinity and orally available P-glycoprotein (Pgp) modulator</p>Formule :C41H72N2O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :689.02P-gp modulator 3
<p>P-gp modulator 3 (Compound 37) is a potent, competitive, metabotropic P-glycoprotein (P-gp) modulator.</p>Formule :C31H37N3O5Couleur et forme :SolidMasse moléculaire :531.64(R)-Duloxetine
CAS :<p>(R)-Duloxetine, an isomer of Duloxetine, induces tonic and use-dependent blockade of neuronal Na+ channels. This compound is utilized in pain research.</p>Formule :C18H19NOSCouleur et forme :SolidMasse moléculaire :297.42Cav 3.2 inhibitor 1
<p>Cav 3.2 inhibitor 1 targets T-type calcium channels, weakly binds D2 receptors, and aids physical and visceral pain research.</p>Formule :C32H39N3OCouleur et forme :SolidMasse moléculaire :481.67TP003
CAS :<p>TP003 is a novel non-selective GABAA receptor benzodiazepine site agonist with affinity for α1β2gam2, α2β3gam2, α3β3gam2, α5β2gam2, EC50 of 20.3, 10.6, 3.24, 5.</p>Formule :C23H16F3N3ODegré de pureté :99.17%Couleur et forme :SolidMasse moléculaire :407.39DAD
<p>DAD is an ion channel blocker (blocks voltage-gated potassium channels) and is a third generation photoelectric switch that responds to visible light.</p>Formule :C26H40N6OCouleur et forme :SolidMasse moléculaire :452.64P-gp/BCRP-IN-1
CAS :<p>P-gp/BCRP-IN-1, safe and oral, inhibits P-gp/BCRP transporters, enhancing Paclitaxel bioavailability.</p>Formule :C27H25ClN4O3Couleur et forme :SolidMasse moléculaire :488.97TRPC5-IN-4
CAS :<p>TRPC5-IN-4: Potent, safe inhibitor; IC50 14.07 nM (TRPC5), 65 nM (TRPC4); non-toxic to liver/kidney cells; for CKD research.</p>Formule :C18H11ClF4N4O3Couleur et forme :SolidMasse moléculaire :442.75Suloctidil HCl
CAS :<p>Suloctidil HCl is a peripheral vascular dilator.</p>Formule :C20H36ClNOSCouleur et forme :SolidMasse moléculaire :374.02SC-435 mesylate
CAS :<p>SC-435 is an ileal apical sodium co-dependent bile acid transporter (ASBT). SC-435 inhibits plasma cholesterol.</p>Formule :C37H59N3O7S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :722.01Tuclazepam
CAS :<p>Tuclazepam (KC 1956) is a derivative of the benzodiazepine class of drugs, exhibiting anti-anxiety and sedative properties.</p>Formule :C17H16Cl2N2OCouleur et forme :SolidMasse moléculaire :335.23KCC2 Modulator-2
CAS :<p>KCC2 Modulator-2 (example 53) is a regulator of KCC2 with an EC50 of 0.215 μM. It is used in the research of neurological diseases.</p>Formule :C35H45N5O3Couleur et forme :SolidMasse moléculaire :583.76N-Depropylpropafenone
CAS :<p>N-Depropylpropafenone, an active metabolite of Propafenone, is produced through the metabolism by the CYP450 enzyme system (primarily CYP2D6). It functions by blocking sodium ion channels, thereby delaying the depolarization process in myocardial cells and exhibiting antiarrhythmic properties.</p>Formule :C18H21NO3Couleur et forme :SolidMasse moléculaire :299.36Desmethylflunitrazepam
CAS :<p>Desmethylflunitrazepam (Norflunitrazepam) is a benzodiazepine derivative and an active metabolite of Flunitrazepam.</p>Formule :C15H10FN3O3Couleur et forme :SolidMasse moléculaire :299.26Tizolemide
CAS :<p>Tizolemide, a sulfonamide diuretic compound with alkaline properties, is cleared through the tubular transport system. It induces changes in the passive transport components across the basolateral membrane of isolated frog skin.</p>Formule :C11H14ClN3O3S2Couleur et forme :SolidMasse moléculaire :335.83cis-KV1.3-IN-1
CAS :<p>cis-KV1.3-IN-1, also known as Compound cis-18, is the cis-isomer of KV1.3-IN-1 and functions as an inhibitor of the KV1.3 channel. In Xenopus laevis oocytes expressing human hKV1.3, cis-KV1.3-IN-1 (10 μM) achieves an inhibition rate of 25.53% against KV1.3.</p>Formule :C23H30N2O4SCouleur et forme :SolidMasse moléculaire :430.56Cyazofamid
CAS :<p>Cyazofamid functions as a fungicide by impairing the production of ATP. It inhibits Organic Cation Transporter 3 (OCT3) and OAT1 with IC50 values of 1.54 and 17.3 μM, respectively.</p>Formule :C13H13ClN4O2SCouleur et forme :SolidMasse moléculaire :324.79Lu AF90103
CAS :<p>Lu AF90103 (Compound 42e) is the methyl ester prodrug of compound 42d, capable of crossing the blood-brain barrier. Compound 42d acts as a partial agonist of the GluN1/GluN2B complex, with an efficacy of 24% and an EC50 value of 78 nM. Lu AF90103 plays a significant role in neuropsychiatric disorder research.</p>Formule :C13H15N3O3SCouleur et forme :SolidMasse moléculaire :293.342Cav 2.2/3.2 blocker 1
<p>Compound 9e is a Cav 2.2/3.2 blocker; IC50: 1.22 μM & 80 μM, respectively; penetrates CNS.</p>Formule :C28H30N2O3Couleur et forme :SolidMasse moléculaire :442.55Ro-51
CAS :<p>dual P2X3 and P2X2/3 antagonist</p>Formule :C17H23IN4O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :474.29Quinacainol dihydrochloride
CAS :<p>Quinacainol dihydrochloride (PK 10139 dihydrochloride) is the bis(2 hydrochloride) salt form of Quinacainol. It acts as an inhibitor of the sodium current, with an EC50 of 95 µM. This compound displays antiarrhythmic activity by modulating the electrophysiological properties of the heart.</p>Formule :C21H32Cl2N2OCouleur et forme :SolidMasse moléculaire :399.398IAB15
CAS :<p>IAB15 is a potent inhibitor of T-type calcium channel that can be used in the research of epilepsy [1].</p>Formule :C15H14F3NO2Couleur et forme :SolidMasse moléculaire :297.27SGE-516
CAS :<p>SGE516: neuroactive steroid, enhances GABAA, lowers neuronal activity, protects from seizures.</p>Formule :C23H35N3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :385.54TTA-P1
CAS :<p>TTA-P1: potent T-type calcium channel inhibitor; impacts neuron firing, hormone secretion, cell growth; potential in absence epilepsy research.</p>Formule :C19H27Cl2FN2OCouleur et forme :SolidMasse moléculaire :389.33YY-23
CAS :<p>YY-23 is a selective NMDAR (containing GluN2C or GluN2D) inhibitor. By inhibiting NMDARs with GluN2D on GABAergic interneurons in the prefrontal cortex, YY-23 suppresses GABAergic neurotransmission and enhances excitatory transmission. YY-23 exhibits antidepressant activity and is useful for neurological disease research.</p>Formule :C33H54O8Couleur et forme :SolidMasse moléculaire :578.777LY3130481
CAS :<p>LY3130481: TARP γ-8 dependent AMPA receptor blocker; selectively targets AMPA/TARP γ-8 with 65 nM IC50.</p>Formule :C19H18N4O3SCouleur et forme :SolidMasse moléculaire :382.44Cav 3.2 inhibitor 2
<p>Cav 3.2 inhibitor 2 blocks T-type Ca2+ channels (IC50=0.09339 μM) and reduces mouse somatic/visceral pain. Used for intractable pain studies.</p>Formule :C32H37F2N3OCouleur et forme :SolidMasse moléculaire :517.65MSK-195
CAS :<p>MSK-195 is an effective TRPV1 agonist.</p>Formule :C28H40N2O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :484.63Kv7.2/Kv7.3 modulator-1
CAS :<p>Kv7.2/Kv7.3 modulator-1 (compound 6a) acts as a modulator for Kv7.2/Kv7.3 channels, with a pEC50 value of 7.96 for opening these channels. Kv7.2/Kv7.3 modulator-1 is applicable in research related to epilepsy, depression, brain injury, and pain.</p>Formule :C20H21F4N3O3Couleur et forme :SolidMasse moléculaire :427.393SR 33805 oxalate
CAS :<p>Ca2+ channel antagonist</p>Formule :C34H42N2O9SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :654.77T-Type calcium channel inhibitor 2
<p>Compound 6g inhibits T-type Ca channels (IC50: Cav3.1-31μM, Cav3.2-83μM), cytotoxic to A549 (IC50: 5μM) & HCT-116 cells (IC50: 6.4μM).</p>Formule :C36H39FN4OSCouleur et forme :SolidMasse moléculaire :594.78ATP synthase inhibitor 2
CAS :<p>ATP synthase inhibitor 2 blocks P. aeruginosa ATP synthase; IC50=10 μg/mL, fully inhibits at 128 μg/mL.</p>Formule :C21H22N2O3SCouleur et forme :SolidMasse moléculaire :382.48264W94
CAS :<p>264W94 robustly inhibits IBAT, induces CYP7A1, and significantly reduces cholesterol.</p>Formule :C23H31NO4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :417.56CFTR corrector 18
CAS :<p>CFTRcorrector 18 (Compound I-99) acts as a modulator of the cystic fibrosis transmembrane conductance regulator (CFTR). It enhances the processing and trafficking of CFTR, thereby increasing the amount of CFTR present on the cell surface. CFTRcorrector 18 holds potential for research in cystic fibrosis (CF).</p>Formule :C38H40N6O5SCouleur et forme :SolidMasse moléculaire :692.826P2X4-IN-1
CAS :<p>P2X4-IN-1 is an orally active P2X4 inhibitor. P2X4-IN-1 is applicable in research focused on disease prevention.</p>Formule :C18H14ClN5O3SCouleur et forme :SolidMasse moléculaire :415.85ML-SI1
CAS :<p>ML-SI1, a racemic mixture of diastereoisomers, is a TRPML inhibitor and acts on TRPML1 (IC50: 15 μM).</p>Formule :C23H26Cl2N2O3Couleur et forme :SolidMasse moléculaire :449.373-Bromoamphetamine hydrochloride
CAS :<p>3-Bromoamphetamine hydrochloride is a para-substituted amphetamine that functions as a monoamine releaser.</p>Formule :C9H13BrClNCouleur et forme :SolidMasse moléculaire :250.563PF-06305591 dihydrate
<p>PF-06305591 dihydrate is a potent and highly selective voltage gated sodium channel NaV1.8 blocker (IC 50 = 15 nM) with an excellent preclinical in vitro ADME</p>Formule :C15H26N4O3Couleur et forme :SolidMasse moléculaire :310.39Mibefradil dihydrochloride hydrate
CAS :<p>Mibefradil dihydrochloride hydrate is a long-acting antihypertensive blocking high-voltage L calcium channels.</p>Formule :C29H42Cl2FN3O4Couleur et forme :SolidMasse moléculaire :586.57LY 235959
CAS :<p>LY 235959 is a NMDA receptor antagonist.</p>Formule :C11H20NO5PDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :277.25CRM1 degrader 1
<p>CRM1 degrader 1 (1l) is a low-toxic CRM1 degrader that induces apoptosis in gastric carcinoma and selectively inhibits the proliferation of gastric cancer[1].</p>Formule :C16H20O3Couleur et forme :SolidMasse moléculaire :260.33PDE2 inhibitor 6
CAS :<p>PDE2 inhibitor6 (Compound 1) is an orally active phosphodiesterase (PDE) inhibitor, effectively inhibiting PDE2A, PDE3B, and PDE10A2 with IC50 values of 0.95 nM, 6.17 μM (pIC50=5.21), and 87.1 nM (pIC50=7.06), respectively. It modulates AMPA receptor activity, enhances synaptic plasticity, and improves learning and memory in rat models. Furthermore, PDE2 inhibitor6 possesses blood-brain barrier permeability.</p>Formule :C20H22F2N6OCouleur et forme :SolidMasse moléculaire :400.425Metaphit methylsulfate
CAS :<p>Metaphit methylsulfate is a specific PCP antagonist and an acylating agent for the [3H] phencyclidine binding site in rat brain homogenate. It inhibits PCP-induced motor activity through a presynaptic mechanism.</p>Formule :C19H28N2O3S2Couleur et forme :SolidMasse moléculaire :396.567URAT1 inhibitor 3
<p>URAT1 inhibitor 3: potent oral URAT1 blocker, IC50=0.8 nM, for gout/hyperuricemia study.</p>Formule :C14H8Cl2N2O2Couleur et forme :SolidMasse moléculaire :307.13Unoprostone
CAS :<p>Unoprostone is a prostaglandin F2α analogs (PGAs), and reduces intraocular pressure and is used topically for glaucoma or ocular hypertension.</p>Formule :C22H38O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :382.53S-8510 phosphate
CAS :<p>S-8510 phosphate is an agonist of inverse Benzodiazepine (BDZ) receptor(Kis of 34.6 nM, 36.2 nM for –GABA and +GABA respectively).</p>Formule :C12H13N4O6PDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :340.23Gabaculine HCl
CAS :<p>Gabaculine, an irreversible GABA-T inhibitor (Ki: 2.9 μM), impacts plastid development and affects DPOR/GluTR levels.</p>Formule :C7H10ClNO2Couleur et forme :SolidMasse moléculaire :175.61EMD-95885
CAS :<p>EMD-95885 is a selective antagonist of NMDA receptors containing NR2B subunits, with an IC50 of 3.9 nM. It does not interact with other sites on the NMDA receptor.</p>Formule :C22H23FN2O3Couleur et forme :SolidMasse moléculaire :382.428RO-275
CAS :<p>RO-275 is an HCN1 inhibitor that also inhibits HCN2, HCN3, and HCN4, improving working memory deficits and being used in research on cognitive disorders.</p>Formule :C18H14ClN5ODegré de pureté :98.12% - 98.3%Couleur et forme :SolidMasse moléculaire :351.79Olorigliflozin
CAS :<p>Olorigliflozin is a sodium glucose co-transporter (SGLT) inhibitor with antihyperglycemic properties.</p>Formule :C23H27ClO7Couleur et forme :SolidMasse moléculaire :450.909ARN23765
CAS :<p>ARN23765 is an F508del-CFTR corrector with an EC50 of 38 pM in human bronchial epithelial cells. It enhances the maturation and function of F508del-CFTR at the cell membrane, influencing ion transport and secretion, thereby addressing the pathological mechanisms of cystic fibrosis (CF).</p>Formule :C30H22F5N3O6Couleur et forme :SolidMasse moléculaire :615.504Pyrimidinone 8
CAS :<p>Pyrimidinone 8 is a reversible, linear non-competitive inhibitor of divalent metal transporter 1 (DMT1) with a Ki of 20 μM (hDMT1). It does not affect the surface expression of hDMT1 and is not influenced by extracellular pH. Pyrimidinone 8 inhibits hDMT1-mediated iron uptake, with an IC50 of 13.8 μM.</p>Formule :C10H12N4OCouleur et forme :SolidMasse moléculaire :204.229GABA-IN-4
CAS :<p>GABA-IN-4 (Compound 17) is a derivative of N-(indol-3-ylglyoxylyl)benzylamine. It exhibits high affinity for the benzodiazepine receptor (BzR), the binding site within the GABAA receptor complex, with a Ki value of 67 nM. Benzodiazepines are widely used as anxiolytic, sedative-hypnotic, and anticonvulsant agents.</p>Formule :C17H13ClN2O2Couleur et forme :SolidMasse moléculaire :312.75Zilvetrigine
CAS :<p>Zilvetrigine is a sodium channel (sodium channel) blocker. It can be used as an analgesic.</p>Formule :C20H20ClN3O2Couleur et forme :SolidMasse moléculaire :369.845NMDA agonist 1
CAS :<p>NMDA agonist 1 (compound 42d) is a potent NMDA agonist with a Ki value of 96 nM. It acts as a partial agonist of the GluN1/GluN2B complex, exhibiting an EC50 value of 78 nM.</p>Formule :C12H13N3O3SCouleur et forme :SolidMasse moléculaire :279.315Antidepressant agent 9
CAS :<p>Antidepressant agent 9 (Compound 24) is an orally active inhibitor of NMDAR and SERT, with IC50 values of 3.50 μM and 1044 nM, respectively. It exhibits good metabolic stability and plasma exposure, and demonstrates antidepressant-like effects in the forced swim test in mice.</p>Formule :C17H24N2Couleur et forme :SolidMasse moléculaire :256.386SGC-CAMKK2-1
CAS :<p>SGC-CAMKK2-1 is a selective inhibitor of calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) with an IC50 of 30 nM. It effectively inhibits AMPK phosphorylation in C4-2 cells, exhibiting an IC50 value of 1.6 µM.</p>Formule :C26H23NO3Couleur et forme :SolidMasse moléculaire :397.466Antidepressant agent 8
CAS :<p>Antidepressant agent 8 (Compound 1f) acts as a selective antagonist for the NMDA receptor GluN1/2A (NMDA receptorGluN1/2A), with an IC50 of 2.94 μmol/L. In a hydrocortisone-induced zebrafish depression model, it demonstrates antidepressant-like effects and shows good blood-brain barrier penetration.</p>Formule :C18H23FN4OS2Couleur et forme :SolidMasse moléculaire :394.53O4I4
CAS :<p>O4I4 is an OCT4-inducing compound capable of activating endogenous OCT4 and its associated signaling pathways, shown anti-aging effects.</p>Formule :C15H20N2SDegré de pureté :99.74%Couleur et forme :SolidMasse moléculaire :260.4LY503430
CAS :<p>LY503430: Oral AMPA enhancer with nootropic, neuroprotective properties, mitigates 6-OHDA/MPTP brain damage.</p>Formule :C20H25FN2O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :392.49Antimalarial agent 7
<p>Antimalarial agent 7 is a potent and effective inhibitor of PfATP4. Antimalarial agent 7 has potential for the study of the human plasmodium falciparum.</p>Formule :C23H22F2N4O3Couleur et forme :SolidMasse moléculaire :440.44Olisutrigine bromide
CAS :<p>Olisutrigine bromide is a sodium channel blocker used as an analgesic.</p>Formule :C25H35BrN2Couleur et forme :SolidMasse moléculaire :443.463ErSO-TFPy
CAS :<p>ErSO-TFPy activates the sodium ion channel TRPM4, resulting in an imbalance of intracellular calcium and sodium ions. It exhibits low nanomolar-level cytotoxicity (IC50 = 5-25 nM) by inducing necrosis in ERα+ breast cancer cell lines. Additionally, ErSO-TFPy shows antitumor activity in mouse models.</p>Formule :C19H13F7N2O2Couleur et forme :SolidMasse moléculaire :434.307Moxetomidate
CAS :<p>Moxetomidate is a GABAA receptor (GABAA receptor) agonist with hypnotic properties.</p>Formule :C15H18N2O3Couleur et forme :SolidMasse moléculaire :274.315Crinecerfont tosylate
CAS :<p>Crinecerfont tosylate is an effective oral CRF1 receptor antagonist. It is applicable to studies involving congenital adrenal hyperplasia (CAH).</p>Formule :C34H36ClFN2O4S2Couleur et forme :SolidMasse moléculaire :655.242(3S,6R)-NML
CAS :<p>(3S,6R)-NML is an NMDA receptor antagonist with pIC50 values of 4.8 [GluN1-GluN2A], 4.6 [GluN1-GluN2B], 5.0 [GluN1-GluN2C], and 5.0 [GluN1-GluN2D]. It is applicable in the study of depression.</p>Formule :C20H27NOCouleur et forme :SolidMasse moléculaire :297.435URAT1 inhibitor 2
<p>URAT1 inhibitor 2: oral URAT1/CYP blocker, IC50 of 1.36μM (URAT1), 16.97μM (CYP1A2), 5.22μM (CYP2C9); potential gout treatment.</p>Formule :C21H18BrN3O2SCouleur et forme :SolidMasse moléculaire :456.36Insecticidal agent 21
CAS :<p>Insecticidal agent 21 (Compound 6) is an insecticide targeting Culex pipiens larvae with an LC50 of 0.4 μg/mL. It achieves multi-target neurotoxicity by inhibiting acetylcholinesterase (AChE) and simultaneously targeting other neural receptors, including nicotinic acetylcholine receptors (nAChR), voltage-gated sodium channels (VGSC), and γ-aminobutyric acid receptors (GABAAR). Insecticidal agent 21 shows potent insecticidal activity and can be utilized in the development of new insecticides to combat mosquito resistance to conventional agents.</p>Formule :C37H40ClN3O2Couleur et forme :SolidMasse moléculaire :594.185ATPase-IN-5
CAS :<p>ATPase-IN-5 (Compound 11) is an antifungal Pma1p (H+ -ATPase) inhibitor (IC50 = 12.7 μM) that inhibits the growth of Candida albicans and Saccharomyces cerevisiae.</p>Formule :C10H10N4O3SDegré de pureté :99.19%Couleur et forme :SolidMasse moléculaire :266.28PDE1-IN-4
<p>PDE1-IN-4: inhibits PDE1C/A/B with IC50s 10/145/354 nM, may help study idiopathic pulmonary fibrosis.</p>Formule :C33H33N3O4Couleur et forme :SolidMasse moléculaire :535.63P2X receptor-1
<p>P2X receptor-1 is a potential inhibitor of P2X receptor for the treatment of pain and inflammation.</p>Formule :C14H14ClN3O3S2Couleur et forme :SolidMasse moléculaire :371.865-O-Desmethyl donepezil
CAS :<p>5-O-Desmethyl donepezil is a metabolite of Donepezil that acts as an inhibitor of hERG channels, with an IC50 of 1.5 μM.</p>Formule :C23H27NO3Couleur et forme :SolidMasse moléculaire :365.465ICA-105665
CAS :<p>ICA-105665 is an orally active Kv7.2/7.3/7.5 channel opener, CNS-penetrant with antiseizure effects, and low hepatocyte cytotoxicity.</p>Formule :C19H15F2N3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :355.34GNE-616
CAS :<p>GNE-616: a potent, stable, oral Nav1.7 inhibitor; Ki: 0.79 nM, Kd: 0.38 nM; for chronic pain.</p>Formule :C24H23F4N5O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :537.53
