Transporteur membranaire/Canal ionique
Les inhibiteurs des transporteurs membranaires et des canaux ioniques sont des composés qui bloquent la fonction des protéines responsables du transport des ions, des nutriments et d'autres molécules à travers les membranes cellulaires. Ces inhibiteurs sont essentiels pour étudier la régulation de l'homéostasie cellulaire, la transduction des signaux et la neurotransmission. Les inhibiteurs des transporteurs membranaires et des canaux ioniques sont également importants pour développer des traitements contre des troubles tels que l'épilepsie, les maladies cardiovasculaires et les syndromes métaboliques. Chez CymitQuimica, nous offrons une sélection diversifiée d'inhibiteurs de haute qualité des transporteurs membranaires et des canaux ioniques pour soutenir vos recherches en physiologie, neurosciences et pharmacologie.
Sous-catégories appartenant à la catégorie "Transporteur membranaire/Canal ionique"
- ABC(3 produits)
- ATPase(101 produits)
- Récepteur de l'adiponectine(5 produits)
- CFTR(65 produits)
- Récepteur CGRP(54 produits)
- Canal calcique(541 produits)
- Canal chlorure(53 produits)
- Récepteur GABA(365 produits)
- Transporteur de monoamine(30 produits)
- Transporteur de monocarboxylate(18 produits)
- NKCC(2 produits)
- NPC1L1(3 produits)
- Cotransporteur Na-K-Cl(10 produits)
- OAT(32 produits)
- OCT(7 produits)
- P-gp(55 produits)
- Canal potassique(280 produits)
- Pompe à protons(42 produits)
- SGLT(31 produits)
- Canal sodique(209 produits)
- Canal TRP/TRPV(95 produits)
Affichez 13 plus de sous-catégories
2514 produits trouvés pour "Transporteur membranaire/Canal ionique"
Trier par
Degré de pureté (%)
0
100
|
0
|
50
|
90
|
95
|
100
P-gp modulator-5
P-gp Modulator-5 (compound 25) serves as a modulator of P-gp, effectively inhibiting the proliferation of multidrug-resistant (MDR) tumors. This compound suppresses the function of drug efflux pumps in MDR cells, which results in significant accumulation of ROS and modifications in cell cycle profiles.Formule :C19H16N2O5Couleur et forme :SolidMasse moléculaire :352.34Calcium Ionophore I
CAS :<p>Calcium Ionophore I has a wide range of applications in life science related research.</p>Formule :C38H72N2O8Couleur et forme :SolidMasse moléculaire :685.05-Tridecanol
CAS :5-Tridecanol blocks ion flux in sodium channels.Formule :C13H28ODegré de pureté :97.87%Couleur et forme :SolidMasse moléculaire :200.36Apamin acetate
Apamin acetate: Selective Ca2+-activated K+ channel blocker, 18-amino acid bee venom peptide, promotes synapse repair, anti-inflammatory.Degré de pureté :96.97%Couleur et forme :SolidPF-04745637
CAS :PF-04745637 is a potent and selective TRPA1 antagonist with an IC50 of 17 nM[1].Formule :C27H32ClF3N2O2Degré de pureté :98.88% - 99.3%Couleur et forme :SolidMasse moléculaire :509Ref: TM-T64337
1mg73,00€5mg145,00€10mg197,00€25mg333,00€50mg475,00€100mg655,00€200mg882,00€1mL*10mM (DMSO)163,00€GaTx2
CAS :High-affinity ClC-2 blocker (KD ~50 pM), selective over other ClCs/CFTR/GABAC/CaCC/KV1.2; slows activation, no effect on open channels.Formule :C125H199N39O47S6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3192.54SB-237376
CAS :SB-237376 is a calcium and potassium channel antagonist used to treat cardiac arrhythmias.Formule :C20H25N3O5Degré de pureté :98.88% - 99.81%Couleur et forme :SoildMasse moléculaire :387.43S-Sulfo-L-cysteine sodium salt
CAS :S-Sulfo-L-cysteine sodium salt shows a weak affinity for mGluR1α and mGluR5a at high concentrations and has potential antioxidant activity.Formule :C3H6NNaO5S2Degré de pureté :99.59%Couleur et forme :SolidMasse moléculaire :223.2Ampullosporin A
CAS :Ampullosporin A is a peptaibol-type polypeptide isolated from the fungus Sepedonium ampullosporum (HKI-0053), exhibiting neuromodulatory activity. It inhibits hyperactivity induced by the NMDA receptor antagonist MK-801 and ameliorates social behavior abnormalities caused by subchronic ketamine treatment. Ampullosporin A modulates glutamate receptor activity without affecting dopamine D1 and D2 receptors.Formule :C77H127N19O19Couleur et forme :SolidMasse moléculaire :1622.95MCU-i11
CAS :MCU-i11 is a novel negative modulator of the MCU, binding MICU1 and impairing muscle cell growth.Formule :C28H28N4O5SDegré de pureté :98.3%Couleur et forme :SolidMasse moléculaire :532.61Ref: TM-T9960
1mg160,00€5mg359,00€10mg512,00€25mg847,00€50mg1.159,00€100mg1.568,00€1mL*10mM (DMSO)437,00€Concanamycin B
CAS :Concanamycin B, a macrolide, inhibits V-ATPases (IC50 = 5 nM), blocks vacuole acidification, affects bone resorption, CD8 T cells, and MHC II in B cells.Formule :C45H73NO14Couleur et forme :SolidMasse moléculaire :852.072Myomodulin
CAS :Myomodulin is a neuropeptide present in molluscs, insects, and gastropods.Myomodulin is present in two identified aplysia neurons that contain myomodulin A theFormule :C36H67N11O8S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :846.12Fipronil sulfone
CAS :Fipronil sulfone is an insecticide fipronil. Its metabolite fipronil sulphone is an inhibitor of rat ɑ1β2γ2L GABA(A) receptor.Formule :C12H4Cl2F6N4O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :453.14Chrodrimanin B
CAS :Chrodrimanin B is a useful organic compound for research related to life sciences. The catalog number is T126052 and the CAS number is 132196-54-4.Formule :C27H32O8Couleur et forme :SolidMasse moléculaire :484.54517(R)-Resolvin D1
CAS :Resolvins are anti-inflammatory lipids from EPA and DHA. Resolvin D1, made from DHA, and its aspirin-triggered epimer 17(R)-RvD1, inhibit acute inflammation.Formule :C22H32O5Couleur et forme :SolidMasse moléculaire :376.493c-Met-IN-23
c-Met-IN-23 (Compound 12g) functions as a c-Met inhibitor with an IC50 of 0.052 μM against c-Met. It also inhibits the MDR1 and MRP1/2 pumps in cancerous HepG2 and BxPC3 cells. As such, c-Met-IN-23 serves as an anticancer agent.Formule :C16H13N7OMasse moléculaire :319.11816Ebio3
Ebio3 is a selective potassium ion channel (KCNQ2) inhibitor with an IC50 of 1.2 nM. It binds to the KCNQ2 channel via its hydrophobic tail, causing the inward movement of the S6 helix, which results in the closure of the internal gate. The inhibitory effect of Ebio3 is equally effective on pathogenic KCNQ2 mutants, such as R75C and I238L, reducing their outward current by approximately 80%. Ebio3 holds potential for research in neurological disorders like epilepsy.Formule :C19H23F2N3O2Couleur et forme :SolidMasse moléculaire :363.4Atelopidtoxin
CAS :Atelopidtoxin is a biochemical.Formule :C16H24N8O12SCouleur et forme :SolidMasse moléculaire :552.47Mepivacaine hydrochloride
CAS :Mepivacaine hydrochloride (Mepivacaine HCl) is the hydrochloride salt form of mepivacaine, an amide derivative with local anesthetic properties.Formule :C15H22N2O·HClDegré de pureté :98.76% - 99.94%Couleur et forme :White Or Off White Crystalline PowderMasse moléculaire :282.81Lei-Dab7
CAS :Selective KCa2.2 channel blocker with Kd 3.8 nM, >200-fold specificity, enhances LTP, convulsive in vivo.Formule :C141H236N46O39S6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3392.06Albanin A
Albanin A is a useful organic compound for research related to life sciences and the catalog number is T124310.Formule :C20H18O6Couleur et forme :SolidMasse moléculaire :354.358Charybdotoxin
CAS :Specific inhibitor of the big conductance Ca2+-activated K+ channel.Formule :C176H277N57O55S7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :4295.95Aekatperone
Aekatperone, a reversible KATP channel inhibitor, exhibits an IC50 of 9 μM. It is utilized in research related to congenital hyperinsulinism (CHI).Formule :C20H25N5O2SCouleur et forme :SolidMasse moléculaire :399.51Inaperisone
CAS :Inaperisone: a novel muscle relaxant that indirectly inhibits voiding reflex via brainstem GABAB receptors.Formule :C16H23NODegré de pureté :98.83%Couleur et forme :SolidMasse moléculaire :245.36EVT-401
EVT-401 (P2X7 receptor antagonist-1), a purinergic P2X7 receptor antagonist, demonstrates efficacy in combating neuroinflammation [1].Formule :C22H20F4N2O3Couleur et forme :SolidMasse moléculaire :436.4Margatoxin
CAS :KV1.3 channel blocker, IC50 36 pM, no effect on calcium-activated channels, hinders VEGF-induced Ca++ influx & NO in endothelial cells.Formule :C178H286N52O50S7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :4178.96AVLX-125
CAS :<p>AVLX-125 (UCCB01-125), a potent inhibitor of PSD-95 and PDZ domains, exhibits a dissociation constant (Kd) of 10 nM. It is utilized in researching inflammatory pain [1] [2].</p>Formule :C62H104N10O29Couleur et forme :SolidMasse moléculaire :1453.542,4,6-Tri-tert-butylphenol
CAS :2,4,6-Tri-tert-butylphenol inhibits the Ca2+ ATPase activity of human red blood cell membranes and can be used in related research in the field of life sciences.Formule :C18H30ODegré de pureté :99.55%Couleur et forme :SolidMasse moléculaire :262.44ABCB1-IN-1
ABCB1-IN-1 (compound 3) is a potent inhibitor of ABCB1 that promotes cell apoptosis.Formule :C36H33F3FeN2O4PSCouleur et forme :SolidMasse moléculaire :733.54Oleoyl Serotonin
CAS :<p>Oleoyl Serotonin is an antagonist of hTRPV1 with an IC50 of 2.57 μM.</p>Formule :C28H44N2O2Degré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :440.66Brexanolone caprilcerbate
CAS :Brexanolone caprilcerbate is an effective positive allosteric modulator of the GABAA receptor.Formule :C48H78O12Couleur et forme :SolidMasse moléculaire :847.13Lifastuzumab
CAS :Sulfamethoxazole-NO (SMX-NO) is a SMX-NO derivative and is the primary immunogen for sulfonamide hypersensitivity reactions.Degré de pureté :97% (SDS-PAGE); 99.5% (SEC-HPLC) - 97% (SDS-PAGE); 99.5% (SEC-HPLC)Couleur et forme :LiquidMasse moléculaire :145.5 kDaCavα2δ-IN-1
CAS :Cavα2δ-IN-1 demonstrates exceptional specificity for voltage-gated calcium channels Cavα2δ-1 (with a Ki value of 6 nM), in comparison to Cavα2δ-2 (with a KiFormule :C18H27N5OCouleur et forme :SolidMasse moléculaire :329.448(S)-ABT 102
CAS :N-[(1S)-1H-inden-1-yl]-N'-indazol-4-ylurea is a strong TRPV1 blocker with a 123 nM IC50 against capsaicin.Formule :C21H24N4ODegré de pureté :99.65% - 99.77%Couleur et forme :SoildMasse moléculaire :348.44Ref: TM-T29522L
1mg77,00€5mg158,00€10mg225,00€25mg338,00€50mg472,00€100mg645,00€200mg868,00€1mL*10mM (DMSO)162,00€Rusfertide
CAS :Rusfertide, a peptide mimetic of natural hepcidin, targets and degrades ferroportin, thereby reducing serum iron and transferrin saturation, which helps regulate red blood cell production. It ameliorates conditions such as polycythemia vera, β-thalassemia, and hereditary hemochromatosis [1] [2].Formule :C114H181N27O28S2Couleur et forme :SolidMasse moléculaire :2441.95RN-1665
CAS :RN-1665 is a potent and selective TRPV4 receptor antagonist.Formule :C20H24F5N3O3S2Degré de pureté :99.96%Couleur et forme :SoildMasse moléculaire :513.54JC-229
CAS :JC-229 is a potent and selective TbRPA1 inhibitor that can inhibit RPA1 in Trypanosoma brucei. JC-229 can be used to study human African Trypanosomiasis (HAT).Formule :C20H14Cl4N2O3SDegré de pureté :97.13%Couleur et forme :SolidMasse moléculaire :504.21NF279
CAS :P2X1 antagonistFormule :C49H36N6Na6O23S6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1407.17Prilocaine acetate
Prilocaine acetate, an amino amide compound, functions as a Na/K-ATPase inhibitor, exhibiting neurotoxic effects [1] [2].Formule :C15H24N2O3Couleur et forme :SolidMasse moléculaire :280.36ω-Agatoxin IVA
CAS :Selective blocker of P-type calcium channels (IC50 < 1 - 3 nM). Also inhibits N-type channels at micromolar concentrations.Formule :C217H360N68O60S10Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :5202.25BuChE-IN-9
BuChE-IN-9 (compound 22a), an eqBuChE (equine serum-derived butyrylcholinesterase) inhibitor, exhibits potent activity with an IC50 of 173 nM.Formule :C28H34N4O2Couleur et forme :SolidMasse moléculaire :458.6NHE-1-IN-2
NHE-1-IN-2 (compound 7g) is a potent NHE-1 inhibitor with an IC50 of 0.78 μM. It mitigates left ventricular systolic dysfunction in mouse models of heart failure.Formule :C23H20ClN3O3Couleur et forme :SolidMasse moléculaire :421.11932FD 12-9
CAS :FD 12-9, Anti-glioblastoma activity. is a flavonoid dimer, acts as a dual inhibitor of P-gp and BCRP, with EC50s of 285 nM and 0.9 nM, respectively.Formule :C51H47N3O11Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :877.93Dofetilide N-oxide
CAS :Dofetilide N-oxide (UK-116856) is a metabolite of dofetilide. Dofetilide can block potassium channels and is a tertiary antiarrhythmic drug.Formule :C19H27N3O6S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :457.56UCL 1684 dibromide
CAS :apamin-sensitive Ca2+-activated K+ channel (KCa2.1) blockerFormule :C34H30Br2N4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :654.45GeX-2
CAS :GeX-2 is a truncated analogue of αO-conotoxin. It has the ability to activate GABAB receptors and inhibit α9α10nAChR as well as CaV2.2 channels. Additionally, GeX-2 is effective in alleviating pain in a rat model of chronic constriction injury.Formule :C103H169N43O27Couleur et forme :SolidMasse moléculaire :2441.721-(1-Methyl-1h-pyrazol-4-yl)-ethanone
CAS :1-(1-Methyl-1h-pyrazol-4-yl)-ethanone is a high purity biochemical reagent that can be used in research related to life sciences.Formule :C6H8N2ODegré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :124.14JTS-653
CAS :JTS-653 is a potent TRPV1 antagonist, effective in reducing chronic pain unresponsive to NSAIDs.Formule :C23H21F3N4O4Couleur et forme :SolidMasse moléculaire :474.44AQP4 (205-215)
CAS :AQP4 (205-215) is a fragment of the water channel protein Aquaporin-4 (AQP4). This protein is an autoimmune antigen in optic neuromyelitis and, upon binding with CD40, is upregulated and presented in B cells. AQP4 is associated with neuromyelitis optica (NMO), an autoimmune inflammatory disease of the central nervous system (CNS).Formule :C48H75N13O17SCouleur et forme :SolidMasse moléculaire :1138.25P2X3 antagonist 39
<p>P2X3 antagonist 39 (compound 26a) is a selective P2X3 receptor antagonist with an IC50 of 54.9 nM. It is utilized in the study of neuropathic pain models.</p>Couleur et forme :Odour SolidPinacidil monohydrate
CAS :Pinacidil monohydrate is a potassium channel activator, antihypertensive drug.Formule :C13H21N5ODegré de pureté :99.94% - 99.98%Couleur et forme :PowderMasse moléculaire :263.34GsMTx4
CAS :GsMTx-4, mechanosensitive and stretch-activated ion channel inhibitor (CAS 1209500-46-8).Formule :C185H273N49O45S6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :4095.84CBP-1008
CBP-1008 is a dual-ligand peptide-drug conjugate (PDC) with MMAE, targeting folate receptor (FRα) and TRPV6. It exhibits high binding affinity to FRα and low affinity to TRPV6. CBP-1008 shows antitumor activity and can be utilized for research in advanced solid tumors such as colorectal cancer, breast cancer, non-small cell lung cancer, ovarian cancer, adrenocortical carcinoma, and follicular dendritic cell sarcoma.Couleur et forme :Odour SolidElgodipine
CAS :Elgodipine decreases angina severity, inhibits muscle growth, and is voltage-sensitive, showing promise for angina treatment.Formule :C29H33FN2O6Degré de pureté :99.84% - 99.98%Couleur et forme :SolidMasse moléculaire :524.58MZ82
MZ82, a derivative of Ko 143, is a potent inhibitor of ATP-binding cassette sub-family G member 2 (ABCG2/BCRP), with an IC50 of approximately 23 nM. Compared to Ko 143, MZ82 exhibits significantly enhanced metabolic stability in liver microsomes and shows marked improvement in mice, along with the ability to penetrate the brain.Formule :C26H29N3O3Couleur et forme :SolidMasse moléculaire :431.53Levamlodipine besylate Hemipentahydrate
CAS :<p>Levamlodipine besylate hemipentahydrate is the besylate hemipentahydrate salt form of Levamlodipine. It is an orally effective calcium channel blocker with antioxidative and vasodilatory properties. This compound can reduce serum malondialdehyde (MDA) levels, enhance the activity of superoxide dismutase (SOD), and alleviate oxidative stress. Levamlodipine besylate hemipentahydrate is relevant for research in vascular dementia, hypertension, and cerebrovascular diseases.</p>Formule :C20H25ClN2O5·C6H6O3SH2OCouleur et forme :SolidMasse moléculaire :1224.18TRPA1 Antagonist 3
CAS :TRPA1 Antagonist 3 is a compound with photoswitchable properties that acts as an agonist on the TRPA1 channel, providing the ability for optical control.Formule :C11H8ClN3Couleur et forme :SolidMasse moléculaire :217.66Anticonvulsant agent 9
Anticonvulsant agent 9 (compound 4f) is an activator of the α1β2γ2GABA_A receptor, with an EC50 value of 1.24 μM. It inhibits the inactivation of Nav1.2 channels and exhibits significant anticonvulsant activity.Formule :C22H24N4O2Couleur et forme :SolidMasse moléculaire :376.45AQP3-IN-1
CAS :<p>AQP3-IN-1 (compounds 3), an AQP3 inhibitor, exhibits an IC 50 of 8.91 μM and effectively inhibits melanoma cell proliferation [1].</p>Formule :C11H9AuCl2N2Couleur et forme :SolidMasse moléculaire :437.08ATP Synthesis-IN-2
ATP Synthesis-IN-2 (Compound 5) serves as a potent inhibitor of ATP synthesis activity, displaying significant antibacterial properties with an IC50 value of 0.Couleur et forme :Odour SolidP-gp inhibitor 14
CAS :Compound 8a, also known as P-gp inhibitor 14, demonstrates high affinity as a P-gp inhibitor and effectively reverses P-gp-mediated multidrug resistance (EC 50 = 48.74 nM). Additionally, this compound exhibits a weak inhibitory effect on CYP3A4 activity [1].Formule :C37H38N2O8Couleur et forme :SolidMasse moléculaire :638.71MMK 1
CAS :Potent hFPR2 agonist; EC50: 1 nM (mFPR2), 2 nM (hFPR2), >10,000 nM (hFPR1). Induces monocyte/neutrophil migration, boosts IL-1β/IL-6, activates NADPH-oxidase.Formule :C75H123N19O18SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1610.97AQP4 (201-220) TFA
AQP4 (201-220) TFA is an encephalitogenic epitope of AQP-4. This compound can induce experimental autoimmune encephalomyelitis (EAE), characterized by midline brain lesions, retinal abnormalities, and lesions at the grey/white matter boundary of the spinal cord. AQP-4 is the target antigen in neuromyelitis optica.Couleur et forme :Odour SolidORI-TRN-002
ORI-TRN-002 is an AQP4 inhibitor with an IC50 value of 3 μM. It is applicable in the field of brain edema research.Formule :C10H7N5OMasse moléculaire :213.06506Crofelemer
CAS :Crofelemer (Provir) is an orally active antidiarrheal agent. It targets the cystic fibrosis transmembrane conductance regulator (CFTR) and calcium-activated chloride channels (CACC), which are responsible for chloride and fluid secretion in the gastrointestinal tract. Crofelemer is applicable for research in diarrhea-related conditions.Couleur et forme :SolidAnalgesic/antidepressant agent-1
<p>Analgesic/antidepressant agent-1 (Compound k1) is an orally active N-acetylamino chloro ketone derivative capable of crossing the blood-brain barrier. It exhibits high affinity for NMDA receptors and demonstrates analgesic, anti-inflammatory, and antidepressant properties, with low psychotomimetic activity.</p>Formule :C22H25ClN2O2Couleur et forme :SolidMasse moléculaire :384.9Milbemycin A4
CAS :Milbemycin A4, a distinguished member of the macrocyclic lactones family featuring a unique spiroketal group, is derived from the fermentation of the soil bacterium Streptomyces hygroscopicus subsp. aureolacrimosus. It acts by enhancing the opening of glutamate and GABA-gated chloride channels, rendering it effective as both a nematocide and insecticide.Formule :C32H46O7Couleur et forme :SolidMasse moléculaire :542.713Anticonvulsant agent 8
Anticonvulsant agent 8 (compound D4) is a chemical used in treating epilepsy by inhibiting GABAA currents. In mouse models, its ED50 values are 2.23 mg/kg for the maximal electroshock (MES) test and 24.60 mg/kg for the pentylenetetrazol (PTZ) test.Formule :C15H11N5OCouleur et forme :SolidMasse moléculaire :277.28TNP-ATP triethylammonium salt
CAS :P2X receptor antagonistFormule :C40H77N12O19P3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1123.042JAMI1001A
CAS :JAMI1001A enhances AMPA receptor signaling, slows deactivation/desensitization for flip/flop isoforms.Formule :C16H17F3N4O3SCouleur et forme :SolidMasse moléculaire :402.39D-GsMTx4
TRPC1/6 & Piezo2 inhibitor; mimics GsMTx4; blocks ~70% mechanosensitive currents; aids in mouse heart attack models; protease-resistant.Couleur et forme :SoildS-Bioallethrin
CAS :S-Bioallethrin is a pure S-form of Bioallethrin.Formule :C19H26O3Degré de pureté :98%Masse moléculaire :302.41Brevetoxin B
CAS :Brevetoxin B, a polyketide neurotoxin from Karenia, affects sodium channels causing neurotoxic shellfish poisoning. IC50=15nM.Formule :C50H70O14Couleur et forme :SolidMasse moléculaire :895.096AChE/Aβ-IN-1
AChE/Aβ-IN-1 (compound 32) is a potent, orally active acetylcholinesterase (AChE) inhibitor with an IC50 of 86 nM and an NMDA receptor antagonist targeting theFormule :C20H25BrN4Couleur et forme :SolidMasse moléculaire :401.34HG1 Toxin
<p>HG1 Toxin is a peptide found in the venom of the scorpion Heterometrus fulvipes, known for its ability to inhibit the potassium channel Kv1.3 (potassium channel Kv1.3). Additionally, HG1 Toxin exhibits trypsin inhibitory activity (Ki=107 nM), making it useful for research into autoimmune diseases.</p>Formule :C337H503N103O97S6Masse moléculaire :7736.59176Huwentoxin I
CAS :Huwentoxin I (HWTX-I) is a peptide toxin that targets and inhibits both voltage-gated sodium channels and N-type calcium channels.Formule :C161H246N48O44S6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3750.36SLC26A3-IN-2
CAS :Vilobelimab (CaCP-29) is a human-mouse chimeric IgG antibody targeting human complement component 5a, a C5a inhibitor that inhibits neutrophil activation.Formule :C19H13ClN2O2SDegré de pureté :99.86%Couleur et forme :SolidMasse moléculaire :368.84Hyp9
CAS :Hyp9, a specific agonist for the transient receptor potential canonical 6 (TRPC6) channel, is utilized in spinal cord injury (SCI) research [1].Formule :C18H26O5Couleur et forme :SolidMasse moléculaire :322.40MS7710
MS7710 is a brain-penetrant inhibitor of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels. It reduces Ih current by inhibiting HCN channels, thereby decreasing the activity of dopamine neurons in the ventral tegmental area (VTA). MS7710 effectively improves social interaction deficits and reward-related cognitive flexibility in mouse models of chronic social defeat stress (CSDS) and shows promise for depression research.Couleur et forme :Odour SolidTRPA1-IN-1
CAS :TRPA1-IN-1 is a potent, selective antagonist of the TRPA1 channel, demonstrating significant oral bioavailability as a small molecule.Formule :C19H17ClN6O3Couleur et forme :SolidMasse moléculaire :412.83TRPV4 antagonist 4
CAS :<p>Potent TRPV4 blocker with 22.65 nM IC50; inhibits current and aids acute lung injury.</p>Formule :C28H32Cl2N6OCouleur et forme :SolidMasse moléculaire :539.50Chlorotoxin TFA
Chlorotoxin TFA, a scorpion venom peptide, blocks chloride channels and has anti-cancer properties.Formule :C160H250F3N53O49S11Couleur et forme :SolidMasse moléculaire :4109.74Phe-Met-Arg-Phe amide trifluoroacetate
CAS :Phe-met-arg-phe amide trifluoroacetate is an activator of K+ current with an ED50 of 23nm on the fundus nerve.Formule :C33H44F6N8O8SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :826.81GX 201
CAS :GX 201 is a selective NaV1.7 inhibitor, IC50 of < 3.2 nM for hNaV1.7.Formule :C25H27ClF4N2O4SDegré de pureté :99.81%Couleur et forme :SolidMasse moléculaire :563Antimalarial agent 41
Antimalarial agent 41 (Compound 17) exhibits antimalarial activity by inhibiting the malaria parasite Plasmodium falciparum, with IC50 values of 40 nM for NF54 strain and 76 nM for K1 strain. This compound acts as an inhibitor of P. falciparum phosphatidylinositol-4-kinase β (PfPI4K) and hERG channels, with IC50 values of 53 nM and 3 μM, respectively. Additionally, Antimalarial agent 41 shows cytotoxicity against CHO cells, with an IC50 of 34 μM. It can improve malaria infections and demonstrates favorable pharmacokinetic properties in mouse models.Formule :C19H18F3N5Masse moléculaire :373.15143RuBi-GABA
CAS :Ruthenium-bipyridine-triphenylphosphine caged GABAFormule :C42H39F6N5O2P2RuDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :922.8CPI1
CPI1 is an effective and highly specific inhibitor of multidrug resistance protein 1 (MRP1). It exhibits inhibitory activity against MRP1 at the nanomolar level (Ki: 100 nM) and has minimal effect on P-glycoprotein (Pgp). CPI1 competes with LTC4 for binding to the same site on MRP1, inhibiting ATP hydrolysis and substrate transport. It is useful in research related to drug delivery and addressing cancer chemotherapy resistance.Formule :C111H131N23O30SCouleur et forme :SolidMasse moléculaire :2299.43Trans (2,3)-Dihydrotetrabenazine
CAS :<p>Trans (2,3)-Dihydrotetrabenazine is a Tetrabenazine metabolite, shows inhibition activity on vesicular monoamine transporter (VMAT2).</p>Formule :C19H29NO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :319.44Apamin
CAS :Apamin: 18-amino acid bee venom peptide, blocks SK channels, anti-inflammatory, anti-fibrotic, strongly basic.Formule :C79H131N31O24S4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2027.34TP-050
CAS :TP-050: potent, selective NMDAR agonist, EC50 0.51 µM (GluN2A), 9.6 µM (GluN2D), BBB permeable, boosts hippocampal LTP.Formule :C16H15ClF2N6OCouleur et forme :SolidMasse moléculaire :380.78BKCa activator-1
BKCa activator-1 (Compound 51b) is an orally active activator of BKCa calcium-activated potassium channels with an EC50 of 2.82 μM. It promotes K+ efflux, leading to cell membrane hyperpolarization and inhibition of smooth muscle contraction. In a spontaneous hypertensive rat (SHR) model, it alleviates urinary incontinence and exhibits antitussive effects in a guinea pig cough model.Formule :C22H23F7N2O3Couleur et forme :SolidMasse moléculaire :496.418Nipecotic acid
CAS :<p>Compound PDK0243, with CAS No. 498-95-3, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound PDK0243 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.</p>Formule :C6H11NO2Couleur et forme :Off-White To Pale Yellow-Beige PowderMasse moléculaire :129.16Urease-IN-19
<p>Urease-IN-19 (Compound 3c) is a potent inhibitor of urease, demonstrating an IC50 value of 2.7 µM. It shows potential for use in research related to kidney stones and gastric ulcers.</p>Formule :C17H16FN3SCouleur et forme :SolidMasse moléculaire :313.39BeKm-1
CAS :Potent, selective hERG (KV11.1) blocker; doesn't affect 14 other K+ channels; extends QTc in rabbit heart dose-dependently.Formule :C174H261N51O52S6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :4091.65α5-GABAA receptor modulator 1
α5-GABAA receptor modulator 1 (Compound A-4) is a selective silent allosteric modulator (SAM) targeting the α5 subunit of GABAA receptors, useful for research into central nervous system (CNS) disorders.Formule :C21H20FN3O4Couleur et forme :SolidMasse moléculaire :397.417α-Hydroxywithanolide D
<p>17alpha-Hydroxywithanolide D is an allosteric modulator of the NMDA receptor, with an IC50 of 44.24 nM. This compound exhibits neuroprotective properties and can be utilized in Alzheimer's disease research.</p>Formule :C28H46O7Couleur et forme :SolidMasse moléculaire :494.661Ouabagenin
CAS :Ouabagenin, a naturally occurring LXR ligand with selective agonist activity, functions as an EC 3.6.3.9 (Na(+)/K(+)-transport ATPase) inhibitor [1] [2].Formule :C23H34O8Couleur et forme :SolidMasse moléculaire :438.51(R)-AMPA
CAS :inactive enantiomer of AMPAFormule :C7H10N2O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :186.17Dendrotoxin K
CAS :Dendrotoxin K blocks Kv1.1 channels, modulating glutamate release in CA3 neurons by controlling presynaptic spike timing.Formule :C294H462N84O75S6Couleur et forme :SolidMasse moléculaire :6559.66Agitoxin-2
CAS :Potent Shaker K+ channel blocker (Ki = 0.64 nM). Also inhibits Kv1.3, Kv1.6 and Kv1.1 K+ channels (Ki values are 4, 37 and 44 pM respectively).Formule :C169H278N54O48S8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :4090.87
