Transporteur membranaire/Canal ionique
Les inhibiteurs des transporteurs membranaires et des canaux ioniques sont des composés qui bloquent la fonction des protéines responsables du transport des ions, des nutriments et d'autres molécules à travers les membranes cellulaires. Ces inhibiteurs sont essentiels pour étudier la régulation de l'homéostasie cellulaire, la transduction des signaux et la neurotransmission. Les inhibiteurs des transporteurs membranaires et des canaux ioniques sont également importants pour développer des traitements contre des troubles tels que l'épilepsie, les maladies cardiovasculaires et les syndromes métaboliques. Chez CymitQuimica, nous offrons une sélection diversifiée d'inhibiteurs de haute qualité des transporteurs membranaires et des canaux ioniques pour soutenir vos recherches en physiologie, neurosciences et pharmacologie.
Sous-catégories appartenant à la catégorie "Transporteur membranaire/Canal ionique"
- ABC(3 produits)
- ATPase(93 produits)
- Récepteur de l'adiponectine(5 produits)
- CFTR(64 produits)
- Récepteur CGRP(51 produits)
- Canal calcique(493 produits)
- Canal chlorure(49 produits)
- Récepteur GABA(336 produits)
- Transporteur de monoamine(23 produits)
- Transporteur de monocarboxylate(17 produits)
- NKCC(2 produits)
- NPC1L1(3 produits)
- Cotransporteur Na-K-Cl(8 produits)
- OAT(27 produits)
- OCT(7 produits)
- P-gp(53 produits)
- Canal potassique(276 produits)
- Pompe à protons(39 produits)
- SGLT(30 produits)
- Canal sodique(202 produits)
- Canal TRP/TRPV(92 produits)
Affichez 13 plus de sous-catégories
2270 produits trouvés pour "Transporteur membranaire/Canal ionique"
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(RS)-AMPA hydrobromide
CAS :<p>AMPAR agonist</p>Formule :C7H11BrN2O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :267.08KV1.3-IN-2
CAS :<p>KV1.3-IN-2 (Compound I) selectively inhibits the kv1.3 potassium channel without affecting the hERG channel. It is applicable in research related to immune-associated diseases such as psoriasis, rheumatoid arthritis, and systemic lupus erythematosus.</p>Formule :C16H23ClN2O4Couleur et forme :SolidMasse moléculaire :342.818Opakalim
CAS :<p>Opakalim is an activator of potassium channels (potassium channel) and exhibits anticonvulsant activity.</p>Formule :C18H22F2N4OCouleur et forme :SolidMasse moléculaire :348.39WS-898
<p>WS-898 boosts paclitaxel efficacy in resistant cells by inhibiting ABCB1; IC50: SW620/Ad300 - 5.0 nM, KB-C2 - 3.67 nM, HEK293/ABCB1 - 3.68 nM.</p>Formule :C33H25N7OSCouleur et forme :SolidMasse moléculaire :567.66Blixeprodil
CAS :<p>Blixeprodil (GM-1020) is an orally active NMDA receptor antagonist with an affinity of Ki = 3.25 µM in rat cortical tissue. It inhibits NR1/2A-NMDAR-mediated currents in HEK293 cells with an IC50 of 1.192 µM. Blixeprodil demonstrates antidepressant effects in rat models and exhibits blood-brain barrier permeability.</p>Formule :C13H16FNOCouleur et forme :SolidMasse moléculaire :221.271IAA65
CAS :<p>IAA65 is a potent inhibitor of T-type calcium channels, exhibiting an IC50 value of 18.9 μM, and holds potential for use in epilepsy research [1].</p>Formule :C16H13F6NO2Couleur et forme :SolidMasse moléculaire :365.27VU0463271 quarterhydrate
<p>VU0463271 quarterhydrate is a potent KCC2 antagonist, with an IC 50 of 61 nM [1].</p>Formule :C19H20N4O2S2Couleur et forme :SolidMasse moléculaire :387V-ATPase-IN-1
CAS :<p>V-ATPase-IN-1 (Compound 3b-03) is an inhibitor of Vacuolar-type H+-ATPases (V-ATPase), exhibiting an inhibition constant (IC50) of 194.80 μM and effectively targeting the V-ATPase subunit A with a dissociation constant (Kd) of 0.803 μM. This compound demonstrates insecticidal activity against M. separata (LC50 = 2.64 mM), aiding in the development of chemical insecticides.</p>Formule :C21H20ClNO2Couleur et forme :SolidMasse moléculaire :353.84(S)-Albuterol
CAS :<p>(S)-Albuterol functions as a muscarinic receptor and phospholipase C activator, enhancing the intracellular free calcium concentration in airway smooth muscle cells.</p>Formule :C13H21NO3Couleur et forme :SolidMasse moléculaire :239.311Lubeluzole dihydrochloride
CAS :<p>Lubeluzole (dihydrochloride) acts as a neuroprotective agent by blocking neuronal voltage-gated sodium channels and also affects cardiac sodium channels, exhibiting both tonic and blocking effects. This compound is considered promising in the research of antiarrhythmic agents.</p>Formule :C22H27Cl2F2N3O2SCouleur et forme :SolidMasse moléculaire :506.44Kv7.2/Kv7.3 activator-1
CAS :<p>Kv7.2/Kv7.3 Activator-1 (compound 517) serves as a powerful activator of the Kv7.2/Kv7.3 channels, exhibiting an EC50 value of less than 1 µM. It holds potential for use in neurological disease research.</p>Formule :C19H22F2N4OCouleur et forme :SolidMasse moléculaire :360.40PF-05661014
CAS :<p>PF-05661014, a demethylated analogue of PF-06526290, selectively inhibits Nav1.3 and Nav1.7 currents by stabilizing the inactivated state through interaction with the D4 VSD. This compound is utilized in research focused on sodium channel modulation.</p>Formule :C17H16N4O3S2Couleur et forme :SolidMasse moléculaire :388.46CFTR corrector 16
CAS :<p>CFTRcorrector 16 (Compound 39) is a corrector of the cystic fibrosis transmembrane conductance regulator (CFTR), utilized in the research of cystic fibrosis disease.</p>Formule :C27H26ClN5O2SCouleur et forme :SolidMasse moléculaire :520.05SP100030 analogue 1
CAS :<p>SP100030 analogue 1 (compound 11) is a selective transcription activation (SITA) inhibitor within the SP100030 class, capable of inhibiting XPO1-dependent upregulation of IL2 in a Jurkat-based IL2-Luc reporter assay, with an EC50 of 137 nM.</p>Formule :C13H5ClF7N3OCouleur et forme :SolidMasse moléculaire :387.64CFTR corrector 15
CAS :<p>CFTR Corrector 15 (Compound 4172) serves as a corrector for cystic fibrosis transmembrane conductance regulator (CFTR). When used in combination with VX-809, it addresses the folding defects of F508del-CFTR. CFTR Corrector 15 is also applicable in the research of cystic fibrosis.</p>Formule :C24H22ClN5O2SCouleur et forme :SolidMasse moléculaire :479.98(2S,3S,11bR)-Dihydrotetrabenazine
CAS :<p>(2S,3S,11bR)-Dihydrotetrabenazine ((2S,3S,11bR)-DHTBZ) is a highly selective inhibitor of vesicular monoamine transporter 2 (VMAT2) with a Ki value of 593 nM. It suppresses the vesicular transport of monoamine neurotransmitters, such as dopamine and serotonin, leading to reduced release into the synaptic cleft. This compound holds potential for research in Huntington's disease and other hyperkinetic movement disorders.</p>Formule :C19H29NO3Couleur et forme :SolidMasse moléculaire :319.44S 0960
CAS :<p>S 0960 is a dimeric bile acid analogue, a specific inhibitor of the sodium-dependent bile salt transporter in the ileum, used in metabolic disease research.</p>Formule :C48H79NO8Degré de pureté :99.32% - >99.99%Couleur et forme :SolidMasse moléculaire :798.14Caramboxin
CAS :<p>Caramboxin, a neurotoxin, can induce acute kidney injury.</p>Formule :C11H13NO6Couleur et forme :SolidMasse moléculaire :255.22Dehydroindapamide
CAS :<p>Dehydroindapamide, an indole form of Indapamide, is utilized to quantify the turnover rate of Indapamide in CYP3A4, which is approximately 10 times higher than that of Indoline, with slightly enhanced affinity for CYP3A4.</p>Formule :C16H14ClN3O3SCouleur et forme :SolidMasse moléculaire :363.82Perfluoroheptanesulfonic acid
CAS :<p>Perfluoroheptanesulfonic acid (1-Perfluoroheptanesulfonic acid; Perfluoroheptanesulphonic acid) is a perfluoroalkyl substance (PFAS). This compound has been detected in landfill leachate and has been shown to induce deformities in zebrafish larvae (EC50=168.1 μM). Exposure to PFHpS in fetuses can lead to reduced birth weight.</p>Formule :C7HF15O3SCouleur et forme :SolidMasse moléculaire :450.12ZK 93426 hydrochloride
CAS :<p>benzodiazepine receptor antagonist,competitive</p>Formule :C18H21ClN2O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :348.82CAD204520
CAS :<p>CAD204520 functions as an inhibitor of SERCA (IC50 = 0.34 μM), specifically targeting mutations in the wild-type NOTCH1 protein associated with T-cell acute lymphoblastic leukemia (T-ALL) and mantle cell lymphoma (MCL).</p>Formule :C23H32F3N3O2Couleur et forme :SolidMasse moléculaire :439.51AP-6
CAS :<p>AP-6, a selective TMEM175 inhibitor, enhances lysosomal macromolecular catabolism by acutely inhibiting TMEM175, thus speeding up macrophage and other digestive activities. This compound holds potential for use in Parkinson's disease research due to its role in modulating lysosomal function.</p>Formule :C16H14N4Couleur et forme :SolidMasse moléculaire :262.31AN-988
CAS :<p>AN-988 (compound 6) is a covalent CRM1 inhibitor.</p>Formule :C22H22N2O4SCouleur et forme :SolidMasse moléculaire :410.49Fletazepam
CAS :<p>Fletazepam, a benzodiazepine derivative, exhibits sedative, anti-anxiety, and muscle-relaxant properties. It is utilized in neurological research.</p>Formule :C17H13ClF4N2Couleur et forme :SolidMasse moléculaire :356.74SOAT-IN-1
CAS :<p>SOAT-IN-1 (compound 40) is a potent and selective inhibitor targeting the sodium-dependent organic anion transporter (SOAT), exhibiting IC50 values of 1.6 µM for SOAT and 14.3 µM for NTCP.</p>Formule :C20H16ClN3O6SCouleur et forme :SolidMasse moléculaire :461.88LY 215490
CAS :<p>LY 215490 is a selective AMPA receptor antagonist with neuroprotective properties in rat ischemia.</p>Formule :C13H21N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :279.34Lorajmine
CAS :<p>Lorajmine, a monochloroacetyl derivative of ajmaline, is a class Ia antiarrhythmic agent that is rapidly hydrolyzed to ajmaline by plasma and tissue esterases.</p>Formule :C22H27ClN2O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :402.91PD-217014
CAS :<p>PD-217014 is an α2δ ligand that exhibits visceral analgesic activity and can suppress visceral hypersensitivity. Its antihyperalgesic effects are dose-dependent.</p>Formule :C10H17NO2Couleur et forme :SolidMasse moléculaire :183.25ABCG2-IN-4
CAS :<p>ABCG2-IN-4 (Compound K31) is an orally active ABCG2 inhibitor that reduces the release of Protoporphyrin IX (PPIX) from red blood cells into the plasma and prevents phototoxicity. In mouse models, ABCG2-IN-4 also demonstrates anti-inflammatory and antioxidant properties.</p>Formule :C24H32N4O4Couleur et forme :SolidMasse moléculaire :440.535Detajmium
CAS :<p>Detajmium is an anti-arrhythmia compound. It is an Na(+)-channel-blocking drug with an extremely long recovery from use-dependent sodium channel block.</p>Formule :C27H42N3O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :456.64(+)-Tetrabenazine
CAS :<p>(+)-Tetrabenazine ((3R,11bR)-Tetrabenazine) is a reversible vesicular monoamine transporter 2 (VMAT-2) inhibitor, inhibits transport by VMAT2 with 10-fold</p>Formule :C19H27NO3Degré de pureté :98.31%Couleur et forme :SolidMasse moléculaire :317.42SDZ 220-040
CAS :<p>SDZ 220-040 是一种选择性哺乳动物 NMDA 受体拮抗剂，可诱导根系生长的部分无重力模式 。</p>Formule :C16H16Cl2NO6PDegré de pureté :98.13%Couleur et forme :SolidMasse moléculaire :420.18SYM2206
CAS :<p>SYM2206 is a low affinity non-competitive AMPA receptor antagonist with an IC50 value of 1.6 μM.SYM2206 exhibits anticancer activity by blocking Nav1.6-mediated</p>Formule :C20H22N4O3Degré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :366.41Suzetrigine
CAS :<p>Suzetrigine (VX-548) is an oral NaV1.8 inhibitor with analgesic properties for acute pain research.</p>Formule :C21H20F5N3O4Degré de pureté :98.08% - 99.27%Couleur et forme :SolidMasse moléculaire :473.39Odevixibat
CAS :<p>Odevixibat (A4250) is a selective oral inhibitor for ileal bile acid transport, potentially treating primary biliary cirrhosis.</p>Formule :C37H48N4O8S2Degré de pureté :99.53% - 99.83%Couleur et forme :SolidMasse moléculaire :740.935-Hydroxylansoprazole
CAS :<p>5-Hydroxylansoprazole (AG1908) is the active metabolite of plasma Lansoprazole, inhibits the proton pump, and is used in the study of peptic ulcers.</p>Formule :C16H14F3N3O3SDegré de pureté :99.00%Couleur et forme :SolidMasse moléculaire :385.36(-)-Bicuculline methobromide
CAS :<p>(-)-Bicuculline methobromide is a potent antagonist of GABAA receptor .</p>Formule :C21H20BrNO6Couleur et forme :WhiteMasse moléculaire :462.29Umbellulone
CAS :<p>Umbellulone is a natural product isolated from Umbellularia californica, and stimulates the TRPA1 channel in a subset of peptidergic, nociceptive neurons, activating the trigeminovascular system via this mechanism.</p>Formule :C10H14ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :150.22A-887826
CAS :<p>A-887826 is a selective, orally bioavailable, and voltage-dependent Na(v1.8) channel blocker (IC50: 11 nM). It attenuates neuropathic tactile allodynia in vivo.</p>Formule :C26H29ClN4O3Couleur et forme :SolidMasse moléculaire :480.99Indapamide
CAS :<p>Indapamide (Noranat) is a non-thiazide sulphonamide diuretic compound, generally used in the treatment of hypertension, as well as decompensated cardiac failure.</p>Formule :C16H16ClN3O3SDegré de pureté :98.97% - 99.83%Couleur et forme :SolidMasse moléculaire :365.83Apcin A HCL
CAS :<p>Apcin A HCL is an Apcin derivative. Apcin A HCL is an anaphase-promoting complex (APC) inhibitor. Apcin-A HCL interacts strongly with Cdc20, and inhibits the ubiquitination of Cdc20 substrates. Apcin-A HCL can be used to synthesize the PROTAC CP5V [1].</p>Formule :C10H15Cl4N5O2Degré de pureté :99.30%Couleur et forme :SolidMasse moléculaire :379.07Ref: TM-T001
Produit arrêtéVerapamil EP Impurity C hydrochloride
CAS :<p>NSC-609249 hydrochloride, an impurity of Verapamil, is a calcium channel blocker with potent orally active properties. It also functions as a first-generation P-glycoprotein (P-gp) inhibitor.</p>Formule :C12H20ClNO2Couleur et forme :SolidMasse moléculaire :245.75PF-06761281
CAS :<p>PF-06761281 is a partially selective sodium-coupled citrate transporter protein (NaCT/SLC13A5) inhibitor, oral, reducing plasma glucose concentration.</p>Formule :C13H17NO6Couleur et forme :SolidMasse moléculaire :283.28GNE-9278
CAS :<p>GNE-9278 is a highly selective NMDAR orthosteric modulator that targets the GluN1 transmembrane structural domain (TMD), enhancing peak current and agonist affinity in activated NMDAR.</p>Formule :C21H27N5O3SCouleur et forme :SolidMasse moléculaire :429.54Zastaprazan
CAS :<p>Zastaprazan (JP-1366, compound 6) is a potassium-competitive acid blocker and proton pump inhibitor that suppresses gastric acid secretion, indicated for GERD.</p>Formule :C22H26N4ODegré de pureté :99.97%Couleur et forme :SolidMasse moléculaire :362.48Filapixant
CAS :<p>Filapixant, a purinoreceptor antagonist. This compound serves as the active reference substance for Eliapixant.</p>Formule :C24H26F3N5O3SCouleur et forme :SolidMasse moléculaire :521.562-AEMP TFA
CAS :<p>2-AEMP TFA is a potent and rapidly acting antagonist of GABA(A)-ρ1 receptors. 2-AEMP is an analog of GABA.</p>Formule :C3H10NO3PDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :139.091(±)-Vasicine
CAS :<p>(±)-Vasicine, the racemate of Vasicine, is isolated from Peganum harmala seeds and exhibits anti-ulcer activity.</p>Formule :C11H12N2ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :188.23(Rac)-Lanicemine
CAS :<p>(Rac)-Lanicemine ((Rac)-AZD6765) is the racemate of Lanicemine. Lanicemine (AZD6765) is a low-trapping NMDA channel blocker with a Ki of 0.56-2.1 μM for the NMDA receptor and IC50 values of 4-7 μM and 6.4 μM in CHO and Xenopus oocyte cells, respectively. Lanicemine shows antidepressant effects [1].</p>Formule :C13H14N2Couleur et forme :SolidMasse moléculaire :198.26L-Cysteine S-sulfate sodium salt sesquihydrate
CAS :<p>L-Cysteine S-sulfate sodium salt sesquihydrate is a useful organic compound for research related to life sciences. The catalog number is T64782 and the CAS number is 150465-29-5.</p>Formule :C9H25N3Na3O17S6Couleur et forme :SolidMasse moléculaire :708.63Indoxacarb
CAS :<p>Indoxacarb is an Oxadiazine insecticide.</p>Formule :C22H17ClF3N3O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :527.833-Methylglutaconic acid
CAS :<p>3-Methylglutaconic acid, a primary metabolite accumulating in 3-Methylglutaconic aciduria (MGTA), induces lipid and protein oxidation, while diminishing non-enzymatic antioxidant defenses in cerebral cortex supernatants, thereby promoting oxidative stress in the cerebral cortex. This compound is utilized in research concerning brain damage diseases [1].</p>Formule :C6H8O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :144.13Alfadolone acetate
CAS :<p>Alfadolone acetate is a gamma-aminobutyric acid (GABA) receptor agonist.</p>Formule :C23H34O5Couleur et forme :SolidMasse moléculaire :390.51Phenamil methanesulfonate
CAS :<p>TRPP3 channel inhibitor</p>Formule :C13H16ClN7O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :401.83CGP 44532
CAS :<p>CGP 44532 a GABAB receptor agonist.</p>Formule :C4H12NO3PDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :153.12CMPDA
CAS :<p>CMPDA is a positive allosteric modulator of AMPA receptors [EC50s: 45.4 nM/63.4 nM for GluA2i/GluA2o receptor].</p>Formule :C16H28N2O4S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :376.53Fostedil
CAS :<p>Fostedil enhances heart function, maintains blood flow during partial/total coronary occlusions, and lowers aortic pressure.</p>Formule :C18H20NO3PSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :361.4Gacyclidine
CAS :<p>Gacyclidine (OTO311), an NMDA receptor blocker, treats tinnitus and injuries in the brain and spinal cord.</p>Formule :C16H25NSDegré de pureté :99.85% - 99.92%Couleur et forme :SolidMasse moléculaire :263.44Pipequaline
CAS :<p>Pipequaline (PK-8165) is an anticonflict & anticonvulsant quinoline derivative. It is an anxiolytic drug that was never marketed. It possesses a novel chemical structure that is not closely related to other drugs of this type. The drug has a similar pharmacological profile to the benzodiazepine family of drugs, but with mainly anxiolytic properties and very little sedative, amnestic or anticonvulsant effects, and so is classified as a nonbenzodiazepine anxiolytic.</p>Formule :C22H24N2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :316.44Tifenazoxide
CAS :<p>Tifenazoxide is an effective and SUR1/Kir6.2 selective KATP channels opener. Tifenazoxide has an anti-diabetic effect, can inhibit glucose-stimulated insulin release in vitro and in vivo.</p>Formule :C9H10ClN3O2S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :291.78Pazinaclone
CAS :<p>Pazinaclone is a non-benzodiazepine (GABAA) partial agonist with sedative and anxiolytic activity.</p>Formule :C25H23ClN4O4Degré de pureté :97.79% - 99.07%Couleur et forme :SolidMasse moléculaire :478.93T16A(inh)-C01
CAS :<p>T16A(inh)-C01 is the Ca(2+)-activated Cl(-) Channel, Ano1 class C inhibitor.</p>Formule :C18H16O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :312.32LFS-1107
CAS :<p>LFS-1107, a reversible CRM1 inhibitor (Kd: 12.5 pM), selectively targets and eliminates ENKTL cells, offering potential for cancer research applications [1].</p>Formule :C12H11N5OS2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :305.38VMAT2-IN-2 tosylate
CAS :<p>VMAT2-IN-2 tosylate is a potent inhibitor of VMAT2 and is applicable in the research of tardive dyskinesia [1].</p>Formule :C27H36F3NO6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :559.64Xilmenolone
CAS :<p>Xilmenolone acts as a positive allosteric modulator of the GABA_A receptor [1].</p>Formule :C26H37N3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :423.59HMR 1556
CAS :<p>HMR 1556 is a chromanol derivative and is an IKs blocker (IC50s of 10.5 nM and 34 nM in canine and guinea pig left ventricular myocytes, respectively).</p>Formule :C17H24F3NO5SCouleur et forme :SolidMasse moléculaire :411.44Belfosdil
CAS :<p>Belfosdil is a blocker of antihypertensive calcium channel.</p>Formule :C27H50O7P2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :548.63CGP 56999A
CAS :<p>CGP 56999A is a GABA(B) receptor antagonist; it boosts BDNF and reduces dopamine loss in rat striatum.</p>Formule :C19H30NO5PDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :383.42Bumetanide sodium
CAS :<p>Bumetanide sodium, a potent diuretic, blocks NKCC1 (IC50: 0.68 μM) and NKCC2 (IC50: 4.0 μM).</p>Formule :C17H19N2NaO5SCouleur et forme :SolidMasse moléculaire :386.4
