Transporteur membranaire/Canal ionique
Les inhibiteurs des transporteurs membranaires et des canaux ioniques sont des composés qui bloquent la fonction des protéines responsables du transport des ions, des nutriments et d'autres molécules à travers les membranes cellulaires. Ces inhibiteurs sont essentiels pour étudier la régulation de l'homéostasie cellulaire, la transduction des signaux et la neurotransmission. Les inhibiteurs des transporteurs membranaires et des canaux ioniques sont également importants pour développer des traitements contre des troubles tels que l'épilepsie, les maladies cardiovasculaires et les syndromes métaboliques. Chez CymitQuimica, nous offrons une sélection diversifiée d'inhibiteurs de haute qualité des transporteurs membranaires et des canaux ioniques pour soutenir vos recherches en physiologie, neurosciences et pharmacologie.
Sous-catégories appartenant à la catégorie "Transporteur membranaire/Canal ionique"
- ABC(3 produits)
- ATPase(93 produits)
- Récepteur de l'adiponectine(5 produits)
- CFTR(64 produits)
- Récepteur CGRP(51 produits)
- Canal calcique(493 produits)
- Canal chlorure(49 produits)
- Récepteur GABA(336 produits)
- Transporteur de monoamine(23 produits)
- Transporteur de monocarboxylate(17 produits)
- NKCC(2 produits)
- NPC1L1(3 produits)
- Cotransporteur Na-K-Cl(8 produits)
- OAT(27 produits)
- OCT(7 produits)
- P-gp(53 produits)
- Canal potassique(276 produits)
- Pompe à protons(39 produits)
- SGLT(30 produits)
- Canal sodique(202 produits)
- Canal TRP/TRPV(92 produits)
Affichez 13 plus de sous-catégories
2270 produits trouvés pour "Transporteur membranaire/Canal ionique"
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Aglafoline
CAS :<p>Aglafoline inhibits in a concentration-dependent manner the aggregation and ATP release reaction induced in washed rabbit platelets by PAF (platelet-activating</p>Formule :C28H28O8Couleur et forme :SolidMasse moléculaire :492.52LY393615
<p>LY393615 (NCC1048) is a novel blocker of both neuronal Ca²⁺ (calcium) and Na⁺ (sodium) channels, exhibiting half-maximal inhibitory concentrations (IC₅₀) of 1.9</p>Degré de pureté :98%Couleur et forme :Odour SolidVerruculogen
CAS :<p>Verruculogen, a toxin from Penicillium/Aspergillus, blocks Ca2+-K+ channels and halts mammalian M phase.</p>Formule :C27H33N3O7Degré de pureté :98%Couleur et forme :White PowderMasse moléculaire :511.57GABA-A Receptor Ligand-1
<p>GABA-A Receptor Ligand-1 (Compound 4) is a ligand for the GABA-A receptor with a pKi of 7.27. It alleviates mitochondrial dysfunction, promotes neurite outgrowth and neuronal regeneration, and demonstrates neuroprotective effects in a rat ischemic stroke model.</p>Formule :C20H20FN3OCouleur et forme :SolidMasse moléculaire :337.391Bafilomycin B1
CAS :<p>Bafilomycin B1, a Streptomyces-derived macrolide, inhibits E. coli ATPase and fights Gram-positive bacteria and fungi.</p>Formule :C44H65NO13Degré de pureté :98%Couleur et forme :White PowderMasse moléculaire :815.998Apamin
CAS :<p>Apamin: 18-amino acid bee venom peptide, blocks SK channels, anti-inflammatory, anti-fibrotic, strongly basic.</p>Formule :C79H131N31O24S4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2027.34BeKm-1
CAS :<p>Potent, selective hERG (KV11.1) blocker; doesn't affect 14 other K+ channels; extends QTc in rabbit heart dose-dependently.</p>Formule :C174H261N51O52S6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :4091.65Cyclic ADP-ribose ammonium
<p>cADPR ammonium is a second messenger that boosts cytosolic calcium via Ryanodine receptors and TRPM2 channels.</p>Couleur et forme :LiquidCamegliptin
CAS :<p>Cameglipti, a dipeptidyl peptidase IV (DPP-4) inhibitor, is used potentially for the treatment of type 2 diabetes.</p>Formule :C20H28FN3O3Couleur et forme :SolidMasse moléculaire :377.45NMDA receptor antagonist 2
CAS :<p>Potent, oral NR2B-selective NMDA receptor antagonist; IC50 of 1.0 nM, Ki of 0.88 nM; used for neuropathic pain and Parkinson's research.</p>Formule :C20H21N7OCouleur et forme :SolidMasse moléculaire :375.436Homocarnosine TFA
<p>Homocarnosine TFA: brain-exclusive GABA-histidine dipeptide, neuronal, anticonvulsant, antioxidant, anti-inflammatory.</p>Formule :C12H17F3N4O5Couleur et forme :SolidMasse moléculaire :354.28NSC799462
<p>NSC799462, a triazole inhibitor, specifically targets p97 ATPase, exerting its effect by binding to a designated site on the p97 enzyme. This interaction induces localized structural alterations in p97, effectively inhibiting its ATPase activity with an IC 50 value of 15 nM.</p>Formule :C30H32F2N6O3SCouleur et forme :SolidMasse moléculaire :594.68TET-13
<p>TET-13 is a positive allosteric modulator of the GABAA receptor with an EC50 of 5.65 μM, which is more potent than Etomidate (EC50: 9.29 μM). It exhibits strong anesthetic effects in both mice and rats, with an ED50 of 0.48 mg/kg in mice and 0.69 mg/kg in rats.</p>Formule :C15H16N2O3SCouleur et forme :SolidMasse moléculaire :304.36Idrevloride
CAS :<p>Idrevloride (WO2016133967) inhibits ENaC, used in skin disorder research.</p>Formule :C30H49ClN8O7Couleur et forme :SolidMasse moléculaire :669.223-Aminopropylphosphonic Acid
CAS :<p>3-aminopropylphosphonic acid (3-APPA) is a phosphonic analog of GABA that acts as a partial agonist of GABAB receptors (IC50 = 1.5 μM in a radioligand binding</p>Formule :C3H10NO3PDegré de pureté :99.84%Couleur et forme :Light Yellow LiquidMasse moléculaire :139.09NSC265473
CAS :<p>NSC265473 is an ABCG2 substrate.</p>Formule :C21H35N3O4SCouleur et forme :SolidMasse moléculaire :425.58Bendroflumethiazide
CAS :<p>Bendroflumethiazide (Naturetin) is a thiazide diuretic with actions and uses similar to those of HYDROCHLOROTHIAZIDE. It has been used in the treatment of familial hyperkalemia, hypertension, edema, and urinary tract disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p810)</p>Formule :C15H14F3N3O4S2Degré de pureté :98% - >99.99%Couleur et forme :Crystals From Dioxane SolidMasse moléculaire :421.41Dihydroisopimaric acid
CAS :<p>Dihydroisopimaric acid opens BKαβ1 channels - large Ca²⁺-activated K⁺ conductors, verified by whole-cell voltage clamp.</p>Formule :C20H32O2Couleur et forme :SolidMasse moléculaire :304.47Antidepressant agent 3
<p>Agent 3: orally active, antidepressant, anxiolytic, boosts performance and cognition.</p>Formule :C17H30ClN5O2SCouleur et forme :SolidMasse moléculaire :403.97PF-04745637
CAS :<p>PF-04745637 is a potent and selective TRPA1 antagonist with an IC50 of 17 nM[1].</p>Formule :C27H32ClF3N2O2Degré de pureté :98.88% - 99.3%Couleur et forme :SolidMasse moléculaire :509(R)-AMPA
CAS :<p>inactive enantiomer of AMPA</p>Formule :C7H10N2O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :186.17kCAL01
CAS :<p>kCAL01 is a CAL inhibitor with a Ki value of 2.3 μM and holds potential for research in cystic fibrosis (CF).</p>Formule :C36H57N11O9Couleur et forme :SolidMasse moléculaire :787.91CFTR activator 2
CAS :<p>CFTR activator 2 (WAY-326769) is an activator of mutant CFTR (cystic fibrosis transmembrane conductance regulator), which increases ion transport activity and can be used for research into cystic fibrosis (CF).</p>Formule :C27H27N3O3Degré de pureté :99.70%Couleur et forme :SolidMasse moléculaire :441.52Chlorpropylate
CAS :<p>Chlorpropylate is an insecticide.</p>Formule :C17H16Cl2O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :339.21ETD001
CAS :<p>ETD001 is a long-acting ENaC inhibitor with an IC50 value of 57.5 nM in HBE cells. It is applicable for research in cystic fibrosis.</p>Formule :C41H57F6N9O16Couleur et forme :SolidMasse moléculaire :1045.9318β-Glycyrrhetyl-3-O-sulfate
CAS :<p>18β-Glycyrrhetyl-3-O-sulfate (Glycyrrhetic acid 3-O-(hydrogen sulfate)), a major metabolite of Glycyrrhetinic acid (GA), serves as a potent inhibitor of type 2</p>Formule :C30H46O7SCouleur et forme :SolidMasse moléculaire :550.75ANO1-IN-4
CAS :<p>ANO1-IN-4 (Compound 10bm) is a reversible inhibitor of the calcium-activated chloride channel transmembrane protein 16A (TMEM16A, also known as ANO1), with an IC50 of 0.030 µM. It demonstrates good metabolic stability in rat liver microsomes and can inhibit spontaneous contractions in isolated mouse ileum.</p>Formule :C19H19BrF2N2O2SCouleur et forme :SolidMasse moléculaire :457.33Tertiapin LQ
<p>Kir1.1 channel blocker, 250x selective; Kd: Kir1.1 (1.1 nM), Kir3.1/3.2 (274 nM), Kir3.1/3.4 (361 nM). Tertiapin-Q derivative.</p>Formule :C106H179N33O24S4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2428.03Vesnarinone HCl
<p>Vesnarinone HCl is an oral PDE3 inhibitor improving heart contractility, affecting calcium and potassium flux. Used in heart failure research.</p>Formule :C22H26ClN3O4Degré de pureté :99.17%Couleur et forme :SoildMasse moléculaire :431.91Vanzacaftor
CAS :<p>Vanzacaftor is a CFTR modulator improving protein processing and surface trafficking, restoring chloride transport and aiding cystic fibrosis therapy research.</p>Formule :C32H39N7O4SDegré de pureté :99.14%Couleur et forme :SolidMasse moléculaire :617.764-Hydroxytolbutamide
CAS :<p>4-Hydroxytolbutamide is a drug metabolite derived from the metabolism of Tolbutamide by CYP2C8 and CYP2C9 a sulfonylurea hypoglycemic agent.</p>Formule :C12H18N2O4SDegré de pureté :98%Couleur et forme :White To Off-WhiteMasse moléculaire :286.35Detajmium bitartrate
CAS :<p>Detajmium bitartrate is used as an antiarrhythmic drug.</p>Formule :C31H47N3O9Couleur et forme :SolidMasse moléculaire :605.72S-WJM992
<p>S-WJM992 (compound 10ahb) serves as an antiparasitic agent, effectively inhibiting ATPase activity in high [Na+] environments. It also significantly counteracts parasites resistant to PfATP4 inhibitors. Additionally, S-WJM992 acts as a potential transmission blocker by impeding gamete development and halting the transmission of parasites to mosquitoes during blood feeding.</p>Formule :C22H18ClFN6O3Couleur et forme :SolidMasse moléculaire :468.87L-R4W2
CAS :<p>Vanilloid TRPV1 (VR1) receptor antagonist peptide (IC50 ~ 0.1 μM); blocks Ca2+ currents in dorsal root ganglion neurons. Analgesic in vivo.</p>Formule :C46H71N21O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1014.2Antimalarial agent 41
<p>Antimalarial agent 41 (Compound 17) exhibits antimalarial activity by inhibiting the malaria parasite Plasmodium falciparum, with IC50 values of 40 nM for NF54 strain and 76 nM for K1 strain. This compound acts as an inhibitor of P. falciparum phosphatidylinositol-4-kinase β (PfPI4K) and hERG channels, with IC50 values of 53 nM and 3 μM, respectively. Additionally, Antimalarial agent 41 shows cytotoxicity against CHO cells, with an IC50 of 34 μM. It can improve malaria infections and demonstrates favorable pharmacokinetic properties in mouse models.</p>Formule :C19H18F3N5Masse moléculaire :373.15143Hyp9
CAS :<p>Hyp9, a specific agonist for the transient receptor potential canonical 6 (TRPC6) channel, is utilized in spinal cord injury (SCI) research [1].</p>Formule :C18H26O5Couleur et forme :SolidMasse moléculaire :322.40(±)17-HETE
CAS :<p>Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites.</p>Formule :C20H32O3Couleur et forme :SolidMasse moléculaire :320.473AChE/Aβ-IN-1
<p>AChE/Aβ-IN-1 (compound 32) is a potent, orally active acetylcholinesterase (AChE) inhibitor with an IC50 of 86 nM and an NMDA receptor antagonist targeting the</p>Formule :C20H25BrN4Couleur et forme :SolidMasse moléculaire :401.34AChE/Aβ-IN-2
<p>AChE/Aβ-IN-2 (compound 33) is a powerful, orally active acetylcholinesterase (AChE) inhibitor with an IC50 of 135 nM.</p>Formule :C20H25ClN4Couleur et forme :SolidMasse moléculaire :356.89N-hydroxy Riluzole
CAS :<p>N-hydroxy Riluzole, a metabolite of riluzole, is mainly produced by CYP1A2 in human liver.</p>Formule :C8H5F3N2O2SCouleur et forme :SolidMasse moléculaire :250.20ω-Conotoxin MVIIC
CAS :<p>Peptide neurotoxin; wide spectrum blocker of N, P and Q type calcium channels.</p>Formule :C106H178N40O32S7Degré de pureté :98%Couleur et forme :White Lyophilised SolidMasse moléculaire :2749NF110
CAS :<p>P2X3 antagonist</p>Formule :C41H32N6NaO17S4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1031.97TRPV4 antagonist 3
CAS :<p>TRPV4 antagonist 3 is a TRPV4 antagonist (p IC 50 = 8.4).</p>Formule :C20H18F4N4O3SCouleur et forme :SolidMasse moléculaire :470.44Venturicidin A
CAS :<p>Venturicidin A is a macrolide antibiotic.</p>Formule :C41H67NO11Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :749.97Brevetoxin B
CAS :<p>Brevetoxin B, a polyketide neurotoxin from Karenia, affects sodium channels causing neurotoxic shellfish poisoning. IC50=15nM.</p>Formule :C50H70O14Couleur et forme :SolidMasse moléculaire :895.096Furosemide
CAS :<p>Furosemide is a potent NKCC2 (Na-K-2Cl symporter) inhibitor, used for edema and chronic renal insufficiency.</p>Formule :C12H11ClN2O5SDegré de pureté :99.32% - 99.89%Couleur et forme :Crystals From Aqueous Ethanol Tasteless (Ntp 1992)Masse moléculaire :330.74412,14-Dichlorodehydroabietic acid
CAS :<p>12,14-Dichlorodehydroabietic acid activates BK channels, blocks GABA A receptors, and increases calcium and neurotransmitter release.</p>Formule :C20H26Cl2O2Couleur et forme :SolidMasse moléculaire :369.33URAT1/GLUT9-IN-1
<p>URAT1/GLUT9-IN-1 (compound 29) effectively inhibits urate transporter 1 (URAT1) with an IC50 value of 2.01 μM and glucose transporter 9 (GLUT9) with an IC50 of 18.21 μM. This compound exhibits favorable pharmacokinetic properties and oral bioavailability, making it useful for research in gout and hyperuricemia.</p>Foslevcromakalim
CAS :<p>Foslevcromakalim (QLS-101), an ATP-sensitive potassium channel opener, serves as a proagent for ocular hypotensive effects [1] [2].</p>Formule :C16H19N2O6PCouleur et forme :SolidMasse moléculaire :366.31SG-094
CAS :<p>SG-094 inhibits TPC2, halts RIL175 cell growth, IC50: 3.7 μM for cancer research.</p>Formule :C30H29NO3Degré de pureté :97.06%Couleur et forme :SoildMasse moléculaire :451.56S-Bioallethrin
CAS :<p>S-Bioallethrin is a pure S-form of Bioallethrin.</p>Formule :C19H26O3Degré de pureté :98%Masse moléculaire :302.41AZD-3161
CAS :<p>AZD-3161 is a sodium channel regulator for pain.</p>Formule :C23H21F3N4O4Couleur et forme :SolidMasse moléculaire :474.43α-Amylase/α-Glucosidase-IN-10
<p>α-Amylase/α-Glucosidase-IN-10 (compound 5d) is an inhibitor of α-amylase and α-glucosidase, with IC50 values of 30.39 μM and 65.1 μM, respectively, indicating potential antidiabetic properties. In ADMET (absorption, distribution, metabolism, excretion, and toxicity) predictions, it shows high gastrointestinal (GI) absorption but functions as a substrate for P-glycoprotein (P-gp) and does not cross the blood-brain barrier (BBB), which may pose a risk of central nervous system side effects.</p>Formule :C33H40ClN5O5Masse moléculaire :621.2718Desalkylgidazepam
CAS :<p>Desalkylgidazepam, a benzodiazepine compound, is a metabolite of gidazepam. It is capable of activating both GABA A-type receptors and the translocator protein (TSPO).</p>Formule :C15H11BrN2OCouleur et forme :SolidMasse moléculaire :315.17ω-Agatoxin TK
CAS :<p>Selective blocker of CaV2.1 P/Q-type calcium channels.</p>Formule :C215H337N65O70S10Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :5273.02Anisatin
<p>Anisatin is a useful organic compound for research related to life sciences and the catalog number is T124719.</p>Formule :C15H20O8Couleur et forme :SolidMasse moléculaire :328.317CHET3
CAS :<p>CHET3 is a highly selective allosteric activator for TASK-3-containing K2P channels. CHET3 has shown potent in vivo analgesic effects. Cost-effective and quality-assured.</p>Formule :C21H21N5O3SDegré de pureté :99.64% - >99.99%Couleur et forme :SoildMasse moléculaire :423.49SC 4453
CAS :<p>SC 4453 is a digoxin analog and a cardiac glycoside derivative.</p>Formule :C41H64N2O12Couleur et forme :SolidMasse moléculaire :776.965Transdermal Peptide Disulfide
CAS :<p>TD 1 peptide, an 11-amino acid, binds ATP1B1's C-terminus, enhancing transdermal drug delivery.</p>Formule :C40H64N14O16S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1061.15GSK2332255B
CAS :<p>GSK2332255B: potent TRPC3/6 antagonist; IC50 5 nM (TRPC3), 4 nM (TRPC6); over 100-fold selectivity vs other Ca2+ channels.</p>Formule :C18H19ClFN3O3SCouleur et forme :SolidMasse moléculaire :411.88Nav1.7-IN-8
CAS :<p>Nav1.7-IN-8 selectively inhibits NaV1.7 over hNaV1.1/1.5, affects CYP2C9/3A4 (IC50: 0.17/0.077 μM), and provides rodent pain relief.</p>Formule :C21H12ClF2N5O4S2Couleur et forme :SolidMasse moléculaire :535.93Endosulfan I
CAS :<p>Endosulfan I is one of the two major stereoisomers of the broad-spectrum insecticide Endosulfan inhibi the GABA/benzodiazepine/picrotoxin complex</p>Formule :C9H6Cl6O3SDegré de pureté :99.86%Couleur et forme :SolidMasse moléculaire :406.93µ-Conotoxin-CnIIIC acetate
<p>µ-Conotoxin-CnIIIC acetate is a NaV1.4 sodium channel antagonist, a conotoxin peptide consisting of 22 amino acids, used for muscle relaxation and pain relief.</p>Formule :C92H139N35O28S6·xC2H4O2Degré de pureté :99.94%Couleur et forme :SolidMasse moléculaire :2375.70 (free base)Jingzhaotoxin-IX
<p>Jingzhaotoxin-IX is a C-terminally amidated peptide neurotoxin consisting of 35 amino acid residues.</p>Formule :C171H251N49O48S6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3953.51AZ1422
<p>AZ1422 is a selective MCT4 inhibitor, applicable for cancer research.</p>Formule :C31H40N2O6Masse moléculaire :536.28864Anticancer agent 108
<p>Anticancer Agent 108 (Compound 3.10) serves as a potent P-gp inhibitor exhibiting considerable antitumor properties while maintaining reduced toxicity to both</p>Formule :C18H9NO5S2Couleur et forme :SolidMasse moléculaire :383.4Yaddle1
<p>Yaddle1 is an agonist of the mechanically sensitive ion channel protein Piezo1, with a half-maximal effective concentration (MEC50) of 0.40 μM. It significantly induces Ca2+ influx in T cells, prompting T cell activation responses. Yaddle1 is applicable in vaccine adjuvant research.</p>Formule :C14H8ClF3N4OSMasse moléculaire :372.00594Lyso-Globotriaosylceramide (d18:1)
CAS :<p>Lyso-Gb3, lacking fatty acyl, binds Stx1 with cholesterol and phosphatidylcholine, not Stx2; lowers neutrophil viability; accumulates in Fabry disease.</p>Formule :C36H67NO17Couleur et forme :SolidMasse moléculaire :785.922GpTx-1 TFA
<p>GpTx-1 TFA is a polypeptide NaV1.7 sodium channel antagonist isolated from the venom of the Chilean spider Grammostola porter. It exhibits potent inhibitory activity on the NaV1.7 channel with an IC50 value of 10 nM, demonstrating excellent selectivity over NaV1.4 (IC50 = 0.301 μM) and NaV1.5 (IC50 = 4.20 μM) with >20-fold and >950-fold selectivity, respectively.</p>Couleur et forme :Odour SolidJYL-79
CAS :<p>JYL-79 is an agonist of the vanilloid receptor.</p>Formule :C26H36N2O4SCouleur et forme :SolidMasse moléculaire :472.64Caloxin 2A1 acetate
<p>Caloxin 2A1 acetate is an inhibitor of extracellular plasma membrane Ca2+-ATPase (PMCA) peptide.</p>Formule :C66H95N19O24Degré de pureté :98.2%Couleur et forme :SolidMasse moléculaire :1538.57PDZ1 Domain inhibitor peptide
CAS :<p>Novel cyclic peptide that disrupts interaction between GluR6 and PSD-95</p>Formule :C38H61N9O11Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :819.94Concanamycin B
CAS :<p>Concanamycin B, a macrolide, inhibits V-ATPases (IC50 = 5 nM), blocks vacuole acidification, affects bone resorption, CD8 T cells, and MHC II in B cells.</p>Formule :C45H73NO14Couleur et forme :SolidMasse moléculaire :852.072ORI-TRN-002
<p>ORI-TRN-002 is an AQP4 inhibitor with an IC50 value of 3 μM. It is applicable in the field of brain edema research.</p>Formule :C10H7N5OMasse moléculaire :213.06506P-gp inhibitor 23
<p>P-gp inhibitor 23 (compound 14F) is an effective inhibitor of both P-gp and CYP3A4, with an EC50 of 28 nM for P-gp and an IC50 of 223 nM for CYP3A4.</p>Formule :C40H37N5O6Masse moléculaire :683.27438KNa1.1-IN-2
CAS :<p>KNa1.1-IN-2 (Compound Z05) is a selective KNa1.1 channel inhibitor capable of penetrating the blood-brain barrier, and exhibits significant efficacy on hERG channels. It binds to KNa1.1 channels, effectively blocking channel activity caused by Gain-of-function (GOF) mutations, thus intervening in KCNT1-related seizures. Additionally, it inhibits the GOF mutant Y796H, making KNa1.1-IN-2 a promising candidate for research into KCNT1-associated epilepsy disorders.</p>Formule :C24H27NOCouleur et forme :SolidMasse moléculaire :345.48Ampullosporin A
CAS :<p>Ampullosporin A is a peptaibol-type polypeptide isolated from the fungus Sepedonium ampullosporum (HKI-0053), exhibiting neuromodulatory activity. It inhibits hyperactivity induced by the NMDA receptor antagonist MK-801 and ameliorates social behavior abnormalities caused by subchronic ketamine treatment. Ampullosporin A modulates glutamate receptor activity without affecting dopamine D1 and D2 receptors.</p>Formule :C77H127N19O19Couleur et forme :SolidMasse moléculaire :1622.95MRS4596
<p>MRS4596: selective P2X4 blocker, IC50 1.38 μM, neuroprotective in stroke research.</p>Formule :C21H14N5NaO3SCouleur et forme :SolidMasse moléculaire :439.42GsMTx4
CAS :<p>GsMTx-4, mechanosensitive and stretch-activated ion channel inhibitor (CAS 1209500-46-8).</p>Formule :C185H273N49O45S6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :4095.84Oleoyl-D-lysine
CAS :<p>Oleoyl-D-lysine: lipid-based GlyT2 inhibitor, eases neuropathic pain in mice, safe, non-sedative, no respiratory depression.</p>Formule :C24H46N2O3Couleur et forme :SolidMasse moléculaire :410.63APETx2 TFA
<p>APETx2 TFA from sea anemone is a selective ASIC3 inhibitor with a 63 nM IC50, reversing acid and inflammatory pain.</p>Formule :C198H281F3N54O62S6Couleur et forme :SolidMasse moléculaire :4675.02Ion Channel Targeted Library
<p>A unique collection of 931 compounds targeting ion channels for research in ion channels-related diseases and ion channel drug discovery;</p>Couleur et forme :Odour Solid(1S,3R)-3-Aminocyclopentane carboxylic acid
CAS :<p>(1S,3R)-3-Aminocyclopentane carboxylic acid exhibits activity on GABAA receptors.</p>Formule :C6H11NO2Couleur et forme :SolidMasse moléculaire :129.16Chlorotoxin
CAS :<p>Chlorotoxin: 36-amino acid peptide from deathstalker scorpion venom; blocks small chloride channels.</p>Formule :C158H249N53O47S11Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3995.71Nav1.7-IN-18
<p>Nav1.7-IN-18 (Compound 31) is a Nav1.7 inhibitor with a Ki value of 4.9 nM and an IC50 of 13 nM, demonstrating analgesic effects in transgenic mice with inherited erythromelalgia (IEM).</p>Formule :C30H33Cl2F2NO4Couleur et forme :SolidMasse moléculaire :580.49Fipronil sulfone
CAS :<p>Fipronil sulfone is an insecticide fipronil. Its metabolite fipronil sulphone is an inhibitor of rat ɑ1β2γ2L GABA(A) receptor.</p>Formule :C12H4Cl2F6N4O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :453.14Chrodrimanin B
CAS :<p>Chrodrimanin B is a useful organic compound for research related to life sciences. The catalog number is T126052 and the CAS number is 132196-54-4.</p>Formule :C27H32O8Couleur et forme :SolidMasse moléculaire :484.545CW2158
<p>CW2158 (Compound 13) is a modulator of exportin1 (XPO1). It disrupts chromatin binding and inhibits the activation of NFAT transcription factors and T cells.</p>Formule :C14H8F4N4O2Masse moléculaire :340.05834Pyrazolam
CAS :<p>Pyrazolam is a psychoactive benzodiazepine compound serving as a central nervous system depressant. [Pyrazolam] can lead to psychomotor impairment.</p>Formule :C16H12BrN5Couleur et forme :SolidMasse moléculaire :354.2Amlenetug
<p>Amlenetug is a humanized IgG1κ antibody targeting SNCA, with its corresponding isotype control being HumanIgG1kappa, Isotype Control.</p>Couleur et forme :Odour LiquidBCRP-IN-2
CAS :<p>BCRP-IN-2 is a compound with BCRP inhibitory activity, exhibiting enhanced inhibition of BCRP upon UV activation. It serves as a valuable probe for studying interactions between quinazoline amine derivatives and BCRP, and it stimulates ATP hydrolysis of the BCRP transporter, leading to increased mitoxantrone accumulation in BCRP-overexpressing H460/MX20 cells.</p>Formule :C19H13N7Couleur et forme :SolidMasse moléculaire :339.35EVT-401
<p>EVT-401 (P2X7 receptor antagonist-1), a purinergic P2X7 receptor antagonist, demonstrates efficacy in combating neuroinflammation [1].</p>Formule :C22H20F4N2O3Couleur et forme :SolidMasse moléculaire :436.4Sinapine hydroxide
CAS :<p>Sinapine hydroxide from crucifer seeds has anti-inflammatory, anti-oxidant, anti-tumor properties, and inhibits AChE, aiding neurodegenerative research.</p>Formule :C16H25NO6Couleur et forme :SolidMasse moléculaire :327.377Guangxitoxin 1E
CAS :<p>Guangxitoxin 1E acts as a gating modifier since it shifts the voltage-dependence of Kv2.1 K+ currents towards depolarized potentials.</p>Formule :C178H248N44O45S7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3948.61Ebio3
<p>Ebio3 is a selective potassium ion channel (KCNQ2) inhibitor with an IC50 of 1.2 nM. It binds to the KCNQ2 channel via its hydrophobic tail, causing the inward movement of the S6 helix, which results in the closure of the internal gate. The inhibitory effect of Ebio3 is equally effective on pathogenic KCNQ2 mutants, such as R75C and I238L, reducing their outward current by approximately 80%. Ebio3 holds potential for research in neurological disorders like epilepsy.</p>Formule :C19H23F2N3O2Couleur et forme :SolidMasse moléculaire :363.4Mepivacaine hydrochloride
CAS :<p>Mepivacaine hydrochloride (Mepivacaine HCl) is the hydrochloride salt form of mepivacaine, an amide derivative with local anesthetic properties.</p>Formule :C15H22N2O·HClDegré de pureté :98.76% - 99.94%Couleur et forme :White Or Off White Crystalline PowderMasse moléculaire :282.81Nitrazolam
CAS :<p>Nitrazolam is a benzodiazepine compound that may exhibit central nervous system depressant properties similar to traditional benzodiazepine drugs by acting on the GABA receptors (GABA receptor). These effects include sedation, hypnosis, anxiolytic, and anticonvulsant activities.</p>Formule :C17H13N5O2Couleur et forme :SolidMasse moléculaire :319.32Digoxigenin Monodigitoxoside
CAS :<p>Digoxigenin monodigitoxoside is a cardiac glycoside metabolite of digoxin and a Na+/K+ ATPase inhibitor.</p>Formule :C29H44O8Couleur et forme :SolidMasse moléculaire :520.663GeX-2
CAS :<p>GeX-2 is a truncated analogue of αO-conotoxin. It has the ability to activate GABAB receptors and inhibit α9α10nAChR as well as CaV2.2 channels. Additionally, GeX-2 is effective in alleviating pain in a rat model of chronic constriction injury.</p>Formule :C103H169N43O27Couleur et forme :SolidMasse moléculaire :2441.721-(1-Methyl-1h-pyrazol-4-yl)-ethanone
CAS :<p>1-(1-Methyl-1h-pyrazol-4-yl)-ethanone is a high purity biochemical reagent that can be used in research related to life sciences.</p>Formule :C6H8N2ODegré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :124.14Albanin A
<p>Albanin A is a useful organic compound for research related to life sciences and the catalog number is T124310.</p>Formule :C20H18O6Couleur et forme :SolidMasse moléculaire :354.358c-Met-IN-23
<p>c-Met-IN-23 (Compound 12g) functions as a c-Met inhibitor with an IC50 of 0.052 μM against c-Met. It also inhibits the MDR1 and MRP1/2 pumps in cancerous HepG2 and BxPC3 cells. As such, c-Met-IN-23 serves as an anticancer agent.</p>Formule :C16H13N7OMasse moléculaire :319.11816Leptomycin A
CAS :<p>Leptomycin A from Streptomyces inhibits CRM1, reducing HIV-1 replication, less potent than Leptomycin B, blocks protein nuclear export.</p>Formule :C32H46O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :526.7Linoleic Acid Amide
CAS :<p>Linoleic Acid Amide (Linoleamide) is derived from linoleic acid and regulates Ca2+ flux by inhibiting the sarco/endoplasmic reticulum Ca2+-ATPase.</p>Formule :C18H33NODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :279.46GaTx2
CAS :<p>High-affinity ClC-2 blocker (KD ~50 pM), selective over other ClCs/CFTR/GABAC/CaCC/KV1.2; slows activation, no effect on open channels.</p>Formule :C125H199N39O47S6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3192.54Fumitremorgin C
CAS :<p>Fumitremorgin C (12α-Fumitremorgin C) is a mycotoxin and inhibits ABCG2/BRCP.</p>Formule :C22H25N3O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :379.45JTS-653
CAS :<p>JTS-653 is a potent TRPV1 antagonist, effective in reducing chronic pain unresponsive to NSAIDs.</p>Formule :C23H21F3N4O4Couleur et forme :SolidMasse moléculaire :474.44CBP-1008
<p>CBP-1008 is a dual-ligand peptide-drug conjugate (PDC) with MMAE, targeting folate receptor (FRα) and TRPV6. It exhibits high binding affinity to FRα and low affinity to TRPV6. CBP-1008 shows antitumor activity and can be utilized for research in advanced solid tumors such as colorectal cancer, breast cancer, non-small cell lung cancer, ovarian cancer, adrenocortical carcinoma, and follicular dendritic cell sarcoma.</p>Couleur et forme :Odour SolidNF279
CAS :<p>P2X1 antagonist</p>Formule :C49H36N6Na6O23S6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1407.17AVLX-125
CAS :<p>AVLX-125 (UCCB01-125), a potent inhibitor of PSD-95 and PDZ domains, exhibits a dissociation constant (Kd) of 10 nM. It is utilized in researching inflammatory pain [1] [2].</p>Formule :C62H104N10O29Couleur et forme :SolidMasse moléculaire :1453.54NHE-1-IN-2
<p>NHE-1-IN-2 (compound 7g) is a potent NHE-1 inhibitor with an IC50 of 0.78 μM. It mitigates left ventricular systolic dysfunction in mouse models of heart failure.</p>Formule :C23H20ClN3O3Couleur et forme :SolidMasse moléculaire :421.11932Oleoyl Serotonin
CAS :<p>Oleoyl Serotonin is an antagonist of hTRPV1 with an IC50 of 2.57 μM.</p>Formule :C28H44N2O2Degré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :440.66Myomodulin
CAS :<p>Myomodulin is a neuropeptide present in molluscs, insects, and gastropods.Myomodulin is present in two identified aplysia neurons that contain myomodulin A the</p>Formule :C36H67N11O8S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :846.123,4-Dihydroxypyrovalerone HCl
CAS :<p>3,4-Dihydroxypyrovalerone HCl is an analog of Pyrovalerone. Pyrovalerone inhibits the dopamine transporter (DAT), serotonin transporter (SERT), and norepinephrine transporter (NET).</p>Formule :C15H22ClNO3Couleur et forme :SolidMasse moléculaire :299.79Rilmazolam
CAS :<p>Rilmazolam is a triazolobenzodiazepine compound and serves as the active metabolite of Rilmazafone.</p>Formule :C19H15Cl2N5OCouleur et forme :SolidMasse moléculaire :400.26JC-229
CAS :<p>JC-229 is a potent and selective TbRPA1 inhibitor that can inhibit RPA1 in Trypanosoma brucei. JC-229 can be used to study human African Trypanosomiasis (HAT).</p>Formule :C20H14Cl4N2O3SDegré de pureté :97.14%Couleur et forme :SolidMasse moléculaire :504.21TPC2-A1-P
CAS :<p>TPC2-A1-P is a TPC2 agonist that can differentially activate two-pore channel 2 (TPC2) and mimic the activation of TPC2 with NAADP and PIP (2).</p>Formule :C20H21BrF3NO3Degré de pureté :98.49%Couleur et forme :SolidMasse moléculaire :460.29(S)-ABT 102
CAS :<p>N-[(1S)-1H-inden-1-yl]-N'-indazol-4-ylurea is a strong TRPV1 blocker with a 123 nM IC50 against capsaicin.</p>Formule :C21H24N4ODegré de pureté :99.65% - 99.77%Couleur et forme :SoildMasse moléculaire :348.44Pinacidil monohydrate
CAS :<p>Pinacidil monohydrate is a potassium channel activator, antihypertensive drug.</p>Formule :C13H21N5ODegré de pureté :99.94% - 99.98%Couleur et forme :PowderMasse moléculaire :263.34Prilocaine acetate
<p>Prilocaine acetate, an amino amide compound, functions as a Na/K-ATPase inhibitor, exhibiting neurotoxic effects [1] [2].</p>Formule :C15H24N2O3Couleur et forme :SolidMasse moléculaire :280.36AR-C141990 hydrochloride
CAS :<p>AR-C141990 HCl inhibits MCT-1 (pKi 7.6) and MCT-2 (pKi 6.6), and has immunosuppressive effects.</p>Formule :C26H29ClN4O4SCouleur et forme :SolidMasse moléculaire :529.05GSK2798745
CAS :<p>GSK2798745 is an orally active transient receptor potential vanilloid 4 (TRPV4) ion channel blocker (IC50s: 1.8 and 1.6 nM for hTRPV4 and rTRPV4).</p>Formule :C25H28N6O3Couleur et forme :SolidMasse moléculaire :460.53Dendrotoxin K
CAS :<p>Dendrotoxin K blocks Kv1.1 channels, modulating glutamate release in CA3 neurons by controlling presynaptic spike timing.</p>Formule :C294H462N84O75S6Couleur et forme :SolidMasse moléculaire :6559.66Milbemycin A4
CAS :<p>Milbemycin A4, a distinguished member of the macrocyclic lactones family featuring a unique spiroketal group, is derived from the fermentation of the soil bacterium Streptomyces hygroscopicus subsp. aureolacrimosus. It acts by enhancing the opening of glutamate and GABA-gated chloride channels, rendering it effective as both a nematocide and insecticide.</p>Formule :C32H46O7Couleur et forme :SolidMasse moléculaire :542.713Dalazatide HCl
<p>Dalazatide HCl is a peptide and specific Kv1.3 inhibitor that suppresses the activation and proliferation of memory effector T cells,</p>Couleur et forme :SolidMasse moléculaire :4317.53 (Free base)P2X3 antagonist 39
<p>P2X3 antagonist 39 (compound 26a) is a selective P2X3 receptor antagonist with an IC50 of 54.9 nM. It is utilized in the study of neuropathic pain models.</p>Couleur et forme :Odour SolidHuwentoxin I
CAS :<p>Huwentoxin I (HWTX-I) is a peptide toxin that targets and inhibits both voltage-gated sodium channels and N-type calcium channels.</p>Formule :C161H246N48O44S6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3750.36TRPV4 antagonist 4
CAS :<p>Potent TRPV4 blocker with 22.65 nM IC50; inhibits current and aids acute lung injury.</p>Formule :C28H32Cl2N6OCouleur et forme :SolidMasse moléculaire :539.50TRPA1 Antagonist 3
CAS :<p>TRPA1 Antagonist 3 is a compound with photoswitchable properties that acts as an agonist on the TRPA1 channel, providing the ability for optical control.</p>Formule :C11H8ClN3Couleur et forme :SolidMasse moléculaire :217.66Anticonvulsant agent 8
<p>Anticonvulsant agent 8 (compound D4) is a chemical used in treating epilepsy by inhibiting GABAA currents. In mouse models, its ED50 values are 2.23 mg/kg for the maximal electroshock (MES) test and 24.60 mg/kg for the pentylenetetrazol (PTZ) test.</p>Formule :C15H11N5OCouleur et forme :SolidMasse moléculaire :277.28CPI1
<p>CPI1 is an effective and highly specific inhibitor of multidrug resistance protein 1 (MRP1). It exhibits inhibitory activity against MRP1 at the nanomolar level (Ki: 100 nM) and has minimal effect on P-glycoprotein (Pgp). CPI1 competes with LTC4 for binding to the same site on MRP1, inhibiting ATP hydrolysis and substrate transport. It is useful in research related to drug delivery and addressing cancer chemotherapy resistance.</p>Formule :C111H131N23O30SCouleur et forme :SolidMasse moléculaire :2299.43UCL 1684 dibromide
CAS :<p>apamin-sensitive Ca2+-activated K+ channel (KCa2.1) blocker</p>Formule :C34H30Br2N4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :654.45Dofetilide N-oxide
CAS :<p>Dofetilide N-oxide (UK-116856) is a metabolite of dofetilide. Dofetilide can block potassium channels and is a tertiary antiarrhythmic drug.</p>Formule :C19H27N3O6S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :457.56BuChE-IN-9
<p>BuChE-IN-9 (compound 22a), an eqBuChE (equine serum-derived butyrylcholinesterase) inhibitor, exhibits potent activity with an IC50 of 173 nM.</p>Formule :C28H34N4O2Couleur et forme :SolidMasse moléculaire :458.6Rusfertide
CAS :<p>Rusfertide, a peptide mimetic of natural hepcidin, targets and degrades ferroportin, thereby reducing serum iron and transferrin saturation, which helps regulate red blood cell production. It ameliorates conditions such as polycythemia vera, β-thalassemia, and hereditary hemochromatosis [1] [2].</p>Formule :C114H181N27O28S2Couleur et forme :SolidMasse moléculaire :2441.95AQP4 (205-215)
CAS :<p>AQP4 (205-215) is a fragment of the water channel protein Aquaporin-4 (AQP4). This protein is an autoimmune antigen in optic neuromyelitis and, upon binding with CD40, is upregulated and presented in B cells. AQP4 is associated with neuromyelitis optica (NMO), an autoimmune inflammatory disease of the central nervous system (CNS).</p>Formule :C48H75N13O17SCouleur et forme :SolidMasse moléculaire :1138.25Phe-Met-Arg-Phe amide trifluoroacetate
CAS :<p>Phe-met-arg-phe amide trifluoroacetate is an activator of K+ current with an ED50 of 23nm on the fundus nerve.</p>Formule :C33H44F6N8O8SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :826.81Lifastuzumab
CAS :<p>Sulfamethoxazole-NO (SMX-NO) is a SMX-NO derivative and is the primary immunogen for sulfonamide hypersensitivity reactions.</p>Degré de pureté :97% (SDS-PAGE); 99.5% (SEC-HPLC) - 97% (SDS-PAGE); 99.5% (SEC-HPLC)Couleur et forme :LiquidMasse moléculaire :145.5 kDaCL-424032
CAS :<p>CL-424032 is an inhibitor of sodium channels (sodium channel).</p>Formule :C12H7F3N4O2Couleur et forme :SolidMasse moléculaire :296.21TNP-ATP triethylammonium salt
CAS :<p>P2X receptor antagonist</p>Formule :C40H77N12O19P3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1123.042GYKI-47261 dihydrochloride
CAS :<p>GYKI-47261 dihydrochloride is an AMPA receptor antagonist and CYP2E1 inducer, demonstrating broad-spectrum anticonvulsant and neuroprotective activities.</p>Formule :C18H17Cl3N4Degré de pureté :98.32% - 99.14%Couleur et forme :SolidMasse moléculaire :395.71RN-1665
CAS :<p>RN-1665 is a potent and selective TRPV4 receptor antagonist.</p>Formule :C20H24F5N3O3S2Degré de pureté :>99.99%Couleur et forme :SoildMasse moléculaire :513.54HG1 Toxin
<p>HG1 Toxin is a peptide found in the venom of the scorpion Heterometrus fulvipes, known for its ability to inhibit the potassium channel Kv1.3 (potassium channel Kv1.3). Additionally, HG1 Toxin exhibits trypsin inhibitory activity (Ki=107 nM), making it useful for research into autoimmune diseases.</p>Formule :C337H503N103O97S6Masse moléculaire :7736.59176GDC-0334
CAS :<p>GDC-0334 is a TRPA1 antagonist useful in treatment TRPA1-mediated diseases, such as pain or asthma.</p>Formule :C24H19F8N5O3SCouleur et forme :SolidMasse moléculaire :609.52,4,6-Tri-tert-butylphenol
CAS :<p>2,4,6-Tri-tert-butylphenol inhibits the Ca2+ ATPase activity of human red blood cell membranes and can be used in related research in the field of life sciences.</p>Formule :C18H30ODegré de pureté :99.55%Couleur et forme :SolidMasse moléculaire :262.43Urease-IN-19
<p>Urease-IN-19 (Compound 3c) is a potent inhibitor of urease, demonstrating an IC50 value of 2.7 µM. It shows potential for use in research related to kidney stones and gastric ulcers.</p>Formule :C17H16FN3SCouleur et forme :SolidMasse moléculaire :313.39GABAA receptor modulator-3
<p>GABAA receptor modulator-3 (compound 3b) is a positive allosteric modulator (PAM). It inhibits the peak current and steady-state current of α1β3γ2 GABAAR with IC50 values of 671 μM and 64 μM, respectively.</p>Formule :C18H22O2Couleur et forme :SolidMasse moléculaire :270.37Cavα2δ-IN-1
CAS :<p>Cavα2δ-IN-1 demonstrates exceptional specificity for voltage-gated calcium channels Cavα2δ-1 (with a Ki value of 6 nM), in comparison to Cavα2δ-2 (with a Ki</p>Formule :C18H27N5OCouleur et forme :SolidMasse moléculaire :329.448Margatoxin
CAS :<p>KV1.3 channel blocker, IC50 36 pM, no effect on calcium-activated channels, hinders VEGF-induced Ca++ influx & NO in endothelial cells.</p>Formule :C178H286N52O50S7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :4178.96Lei-Dab7
CAS :<p>Selective KCa2.2 channel blocker with Kd 3.8 nM, >200-fold specificity, enhances LTP, convulsive in vivo.</p>Formule :C141H236N46O39S6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3392.06P2X4 antagonist-4
<p>P2X4 antagonist-4 (compound 64) is a potent P2X4R antagonist with an IC50 value of 8 µM. It can inhibit ATP-induced activation of the NLRP3 inflammasome and the subsequent release of IL-1β.</p>Formule :C27H22FN3O4SCouleur et forme :SolidMasse moléculaire :503.545BKCa activator-1
<p>BKCa activator-1 (Compound 51b) is an orally active activator of BKCa calcium-activated potassium channels with an EC50 of 2.82 μM. It promotes K+ efflux, leading to cell membrane hyperpolarization and inhibition of smooth muscle contraction. In a spontaneous hypertensive rat (SHR) model, it alleviates urinary incontinence and exhibits antitussive effects in a guinea pig cough model.</p>Formule :C22H23F7N2O3Couleur et forme :SolidMasse moléculaire :496.418D-GsMTx4
<p>TRPC1/6 & Piezo2 inhibitor; mimics GsMTx4; blocks ~70% mechanosensitive currents; aids in mouse heart attack models; protease-resistant.</p>Couleur et forme :Soildω-Agatoxin IVA
CAS :<p>Selective blocker of P-type calcium channels (IC50 < 1 - 3 nM). Also inhibits N-type channels at micromolar concentrations.</p>Formule :C217H360N68O60S10Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :5202.25GX 201
CAS :<p>GX 201 is a selective NaV1.7 inhibitor, IC50 of < 3.2 nM for hNaV1.7.</p>Formule :C25H27ClF4N2O4SDegré de pureté :99.81%Couleur et forme :SolidMasse moléculaire :563ABCB1-IN-1
<p>ABCB1-IN-1 (compound 3) is a potent inhibitor of ABCB1 that promotes cell apoptosis.</p>Formule :C36H33F3FeN2O4PSCouleur et forme :SolidMasse moléculaire :733.54α5-GABAA receptor modulator 1
<p>α5-GABAA receptor modulator 1 (Compound A-4) is a selective silent allosteric modulator (SAM) targeting the α5 subunit of GABAA receptors, useful for research into central nervous system (CNS) disorders.</p>Formule :C21H20FN3O4Couleur et forme :SolidMasse moléculaire :397.4Tacrine hydrochloride
CAS :<p>Tacrine: a cholinergic agonist, anticholinesterase; inhibits AChE/BChE with IC50s of 31/25.6 nM.</p>Formule :C13H15ClN2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :234.73Agitoxin-2
CAS :<p>Potent Shaker K+ channel blocker (Ki = 0.64 nM). Also inhibits Kv1.3, Kv1.6 and Kv1.1 K+ channels (Ki values are 4, 37 and 44 pM respectively).</p>Formule :C169H278N54O48S8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :4090.87Levamlodipine besylate Hemipentahydrate
CAS :<p>Levamlodipine besylate hemipentahydrate is the besylate hemipentahydrate salt form of Levamlodipine. It is an orally effective calcium channel blocker with antioxidative and vasodilatory properties. This compound can reduce serum malondialdehyde (MDA) levels, enhance the activity of superoxide dismutase (SOD), and alleviate oxidative stress. Levamlodipine besylate hemipentahydrate is relevant for research in vascular dementia, hypertension, and cerebrovascular diseases.</p>Formule :C20H25ClN2O5·C6H6O3SH2OCouleur et forme :SolidMasse moléculaire :1224.18Ouabagenin
CAS :<p>Ouabagenin, a naturally occurring LXR ligand with selective agonist activity, functions as an EC 3.6.3.9 (Na(+)/K(+)-transport ATPase) inhibitor [1] [2].</p>Formule :C23H34O8Couleur et forme :SolidMasse moléculaire :438.51GS-9191 PM
<p>GS-9191 PM: novel antitumorviral bis-amide prodrug, inhibits MDR1/BCRP, has antiproliferative activity.</p>Formule :C11H16N6ODegré de pureté :99.79%Couleur et forme :SoildMasse moléculaire :248.28AQP3-IN-1
CAS :<p>AQP3-IN-1 (compounds 3), an AQP3 inhibitor, exhibits an IC 50 of 8.91 μM and effectively inhibits melanoma cell proliferation [1].</p>Formule :C11H9AuCl2N2Couleur et forme :SolidMasse moléculaire :437.08Anticonvulsant agent 9
<p>Anticonvulsant agent 9 (compound 4f) is an activator of the α1β2γ2GABA_A receptor, with an EC50 value of 1.24 μM. It inhibits the inactivation of Nav1.2 channels and exhibits significant anticonvulsant activity.</p>Formule :C22H24N4O2Couleur et forme :SolidMasse moléculaire :376.45PptT-IN-4
<p>PptT-IN-4 (Compound 3a) is a PptT inhibitor exhibiting an IC50 of 0.71 μM.</p>Formule :C17H23N3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :269.38Elgodipine
CAS :<p>Elgodipine decreases angina severity, inhibits muscle growth, and is voltage-sensitive, showing promise for angina treatment.</p>Formule :C29H33FN2O6Degré de pureté :98.95% - 99.50%Couleur et forme :SolidMasse moléculaire :524.585-Tridecanol
CAS :<p>5-Tridecanol blocks ion flux in sodium channels.</p>Formule :C13H28ODegré de pureté :97.87%Couleur et forme :SolidMasse moléculaire :200.3617(R)-Resolvin D1
CAS :<p>Resolvins are anti-inflammatory lipids from EPA and DHA. Resolvin D1, made from DHA, and its aspirin-triggered epimer 17(R)-RvD1, inhibit acute inflammation.</p>Formule :C22H32O5Couleur et forme :SolidMasse moléculaire :376.493P-gp inhibitor 15
<p>P-gp Inhibitor 15 (compound 7a), a nonsubstrate inhibitor of P-glycoprotein (Pgp), inhibits Pgp-ATPase activity and interferes with Pgp-mediated Rhodamine123</p>Formule :C35H60N2O4Couleur et forme :SolidMasse moléculaire :572.86Crofelemer
CAS :<p>Crofelemer (Provir) is an orally active antidiarrheal agent. It targets the cystic fibrosis transmembrane conductance regulator (CFTR) and calcium-activated chloride channels (CACC), which are responsible for chloride and fluid secretion in the gastrointestinal tract. Crofelemer is applicable for research in diarrhea-related conditions.</p>Couleur et forme :SolidAnalgesic/antidepressant agent-1
<p>Analgesic/antidepressant agent-1 (Compound k1) is an orally active N-acetylamino chloro ketone derivative capable of crossing the blood-brain barrier. It exhibits high affinity for NMDA receptors and demonstrates analgesic, anti-inflammatory, and antidepressant properties, with low psychotomimetic activity.</p>Formule :C22H25ClN2O2Couleur et forme :SolidMasse moléculaire :384.9AQP4 (201-220) TFA
<p>AQP4 (201-220) TFA is an encephalitogenic epitope of AQP-4. This compound can induce experimental autoimmune encephalomyelitis (EAE), characterized by midline brain lesions, retinal abnormalities, and lesions at the grey/white matter boundary of the spinal cord. AQP-4 is the target antigen in neuromyelitis optica.</p>Couleur et forme :Odour SolidCalcium Ionophore I
CAS :<p>Calcium Ionophore I has a wide range of applications in life science related research.</p>Formule :C38H72N2O8Couleur et forme :SolidMasse moléculaire :685.0Charybdotoxin
CAS :<p>Specific inhibitor of the big conductance Ca2+-activated K+ channel.</p>Formule :C176H277N57O55S7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :4295.95ATP synthase inhibitor 2 TFA
<p>ATP Synthase Inhibitor 2 (Compound 22) TFA is a potent inhibitor of Pseudomonas aeruginosa ATP synthase with an IC50 value of 10 μg/mL.</p>Formule :C23H23F3N2O5SCouleur et forme :SolidMasse moléculaire :496.5JAMI1001A
CAS :<p>JAMI1001A enhances AMPA receptor signaling, slows deactivation/desensitization for flip/flop isoforms.</p>Formule :C16H17F3N4O3SCouleur et forme :SolidMasse moléculaire :402.39Phe-Met-Arg-Phe, amide
CAS :<p>Phe-Met-Arg-Phe amide activates K+ current in neurons (ED50=23 nM), co-localizes with neuropeptide Y in brain regions.</p>Formule :C29H42N8O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :598.76Tariquidar dimesylate
CAS :<p>Tariquidar, a non-competitive P-glycoprotein inhibitor, may help combat cancer drug resistance.</p>Formule :C80H94N8O25S4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1695.9L-Palmitoylcarnitine TFA
<p>L-Palmitoylcarnitine TFA: long-chain fat metabolite that disrupts membranes in ischaemia & inhibits KATP channels via Kir6.2 interaction.</p>Formule :C25H46F3NO6Couleur et forme :SolidMasse moléculaire :513.63Apamin acetate
<p>Apamin acetate: Selective Ca2+-activated K+ channel blocker, 18-amino acid bee venom peptide, promotes synapse repair, anti-inflammatory.</p>Degré de pureté :96.97%Couleur et forme :SolidRoquefortine C
CAS :<p>Roquefortine C is a fungal cyclopeptide isolated from Penicillium roquefortii, activates P-gp and also inhibits P450-3A and other haemoproteins</p>Formule :C22H23N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :389.45SLC26A3-IN-2
CAS :<p>Vilobelimab (CaCP-29) is a human-mouse chimeric IgG antibody targeting human complement component 5a, a C5a inhibitor that inhibits neutrophil activation.</p>Formule :C19H13ClN2O2SDegré de pureté :99.86%Couleur et forme :SolidMasse moléculaire :368.84P-gp inhibitor 14
CAS :<p>Compound 8a, also known as P-gp inhibitor 14, demonstrates high affinity as a P-gp inhibitor and effectively reverses P-gp-mediated multidrug resistance (EC 50 = 48.74 nM). Additionally, this compound exhibits a weak inhibitory effect on CYP3A4 activity [1].</p>Formule :C37H38N2O8Couleur et forme :SolidMasse moléculaire :638.71MS7710
<p>MS7710 is a brain-penetrant inhibitor of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels. It reduces Ih current by inhibiting HCN channels, thereby decreasing the activity of dopamine neurons in the ventral tegmental area (VTA). MS7710 effectively improves social interaction deficits and reward-related cognitive flexibility in mouse models of chronic social defeat stress (CSDS) and shows promise for depression research.</p>Couleur et forme :Odour SolidATP Synthesis-IN-2
<p>ATP Synthesis-IN-2 (Compound 5) serves as a potent inhibitor of ATP synthesis activity, displaying significant antibacterial properties with an IC50 value of 0.</p>Couleur et forme :Odour SolidWay 125971
CAS :<p>Way 125971 is a bioactive chemcial.</p>Formule :C22H28N4O5S2Couleur et forme :SolidMasse moléculaire :492.61Chlorotoxin TFA
<p>Chlorotoxin TFA, a scorpion venom peptide, blocks chloride channels and has anti-cancer properties.</p>Formule :C160H250F3N53O49S11Couleur et forme :SolidMasse moléculaire :4109.74AQP4 (205-215) TFA
<p>AQP4 (205-215) TFA is a fragment of the water channel protein-4 (AQP4). AQP4 acts as an autoimmune antigen in neuromyelitis optica, upregulating and presenting in B cells upon binding with CD40. AQP4 is associated with neuromyelitis optica (NMO), an autoimmune inflammatory disease of the central nervous system (CNS).</p>Couleur et forme :Odour SolidHomocarnosine
CAS :<p>Homocarnosine is an endogenous dipeptide in cerebral regions and cerebrospinal fluid.</p>Formule :C10H16N4O3Couleur et forme :SolidMasse moléculaire :240.26Quinine hemisulfate hydrate
CAS :<p>Quinine hemisulfate hydrate: anti-malaria, derived from cinchona bark, inhibits mouse Slo3 channels with IC50 169 μM.</p>Formule :C20H26N2O3H2O4S·H2OCouleur et forme :SolidMasse moléculaire :391.47S-Sulfo-L-cysteine sodium salt
CAS :<p>S-Sulfo-L-cysteine sodium salt shows a weak affinity for mGluR1α and mGluR5a at high concentrations and has potential antioxidant activity.</p>Formule :C3H6NNaO5S2Degré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :223.217(S)-HETE
CAS :<p>Arachidonic acid and its CYP450 metabolite, 17(S)-HETE, regulate kidney electrolytes; 17(S)-HETE reduces proximal tubule ATPase activity by 70% at 2 μM.</p>Formule :C20H32O3Couleur et forme :SolidMasse moléculaire :320.473Trans (2,3)-Dihydrotetrabenazine
CAS :<p>Trans (2,3)-Dihydrotetrabenazine is a Tetrabenazine metabolite, shows inhibition activity on vesicular monoamine transporter (VMAT2).</p>Formule :C19H29NO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :319.44MMK 1
CAS :<p>Potent hFPR2 agonist; EC50: 1 nM (mFPR2), 2 nM (hFPR2), >10,000 nM (hFPR1). Induces monocyte/neutrophil migration, boosts IL-1β/IL-6, activates NADPH-oxidase.</p>Formule :C75H123N19O18SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1610.97TP-050
CAS :<p>TP-050: potent, selective NMDAR agonist, EC50 0.51 µM (GluN2A), 9.6 µM (GluN2D), BBB permeable, boosts hippocampal LTP.</p>Formule :C16H15ClF2N6OCouleur et forme :SolidMasse moléculaire :380.78RuBi-GABA
CAS :<p>Ruthenium-bipyridine-triphenylphosphine caged GABA</p>Formule :C42H39F6N5O2P2RuDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :922.8AHN-683
CAS :<p>AHN-683 is a fluorescent ligand. It was used for peripheral-type benzodiazepine receptors.</p>Formule :C42H32FN3O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :709.72NF864
CAS :<p>NF864, a suramin analog, is a P2X1 receptor inhibitor.</p>Formule :C57H28N6Na12O41S12Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2113.5LY-466195
CAS :<p>LY-466195 is a competitive antagonist of GLUK5 receptor.</p>Formule :C16H24F2N2O4Couleur et forme :SolidMasse moléculaire :346.37Spongionellol A
<p>Spongionellol A inhibits MDR1, selectively kills prostate cancer through caspase-induced apoptosis, and aids cancer research.</p>Formule :C27H40O9Couleur et forme :SolidMasse moléculaire :508.6
